{ "dbId" : 10329809, "stableId" : "R-CFA-198933", "displayName" : "Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "nodes" : [ { "id" : 62336, "reactomeId" : 10294366, "displayName" : "CLEC2D dimer", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 1162, "y" : 711 }, "minX" : 1129, "maxX" : 1202, "minY" : 646, "maxY" : 728, "prop" : { "x" : 1129, "y" : 695, "width" : 67, "height" : 33 }, "textPosition" : { "x" : 1133, "y" : 693 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1196, "y" : 695 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1196, "y" : 695 } } }, "connectors" : [ { "edgeId" : 62334, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1165, "y" : 692 }, "to" : { "x" : 1174, "y" : 646 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 62337, "reactomeId" : 10294374, "displayName" : "CLEC2D dimer:KLRB1 dimer", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 1247, "y" : 591 }, "minX" : 1213, "maxX" : 1288, "minY" : 555, "maxY" : 622, "prop" : { "x" : 1213, "y" : 561, "width" : 69, "height" : 61 }, "textPosition" : { "x" : 1218, "y" : 559 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1282, "y" : 561 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1282, "y" : 561 } } }, "connectors" : [ { "edgeId" : 62334, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 62339, "reactomeId" : 10294410, "displayName" : "SIGLEC", "schemaClass" : "CandidateSet", "renderableClass" : "EntitySet", "position" : { "x" : 1317, "y" : 584 }, "minX" : 1293, "maxX" : 1341, "minY" : 572, "maxY" : 664, "prop" : { "x" : 1293, "y" : 572, "width" : 48, "height" : 25 }, "textPosition" : { "x" : 1296, "y" : 567 }, "connectors" : [ { "edgeId" : 62338, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1313, "y" : 603 }, "to" : { "x" : 1296, "y" : 664 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 62340, "reactomeId" : 1006168, "displayName" : "Sialic acid", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1242, "y" : 711 }, "minX" : 1207, "maxX" : 1296, "minY" : 664, "maxY" : 728, "prop" : { "x" : 1207, "y" : 695, "width" : 71, "height" : 33 }, "textPosition" : { "x" : 1207, "y" : 701 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1273, "y" : 700 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1273, "y" : 700 } } }, "connectors" : [ { "edgeId" : 62338, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1260, "y" : 692 }, "to" : { "x" : 1296, "y" : 664 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 62341, "reactomeId" : 10294412, "displayName" : "SIGLEC:sialic acid", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 1400, "y" : 587 }, "minX" : 1363, "maxX" : 1444, "minY" : 562, "maxY" : 607, "prop" : { "x" : 1363, "y" : 568, "width" : 75, "height" : 39 }, "textPosition" : { "x" : 1366, "y" : 572 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1438, "y" : 568 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1438, "y" : 568 } } }, "connectors" : [ { "edgeId" : 62338, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 62343, "reactomeId" : 10294348, "displayName" : "NCR3LG1", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 1483, "y" : 584 }, "minX" : 1451, "maxX" : 1522, "minY" : 567, "maxY" : 655, "prop" : { "x" : 1451, "y" : 573, "width" : 65, "height" : 22 }, "textPosition" : { "x" : 1451, "y" : 573 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1516, "y" : 573 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1516, "y" : 573 } } }, "connectors" : [ { "edgeId" : 62342, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1478, "y" : 598 }, "to" : { "x" : 1452, "y" : 655 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 62344, "reactomeId" : 10294344, "displayName" : "NCR3:FCRG1A:CD3Z dimer", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 1504, "y" : 703 }, "minX" : 1452, "maxX" : 1561, "minY" : 655, "maxY" : 721, "prop" : { "x" : 1454, "y" : 686, "width" : 101, "height" : 35 }, "textPosition" : { "x" : 1456, "y" : 686 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1555, "y" : 686 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1555, "y" : 686 } } }, "connectors" : [ { "edgeId" : 62342, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1485, "y" : 683 }, "to" : { "x" : 1452, "y" : 655 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 62345, "reactomeId" : 10294350, "displayName" : "NCR3LG1:NCR3:FCRG3A:CD3Z dimer", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 1355, "y" : 708 }, "minX" : 1290, "maxX" : 1426, "minY" : 684, "maxY" : 726, "prop" : { "x" : 1290, "y" : 690, "width" : 130, "height" : 36 }, "textPosition" : { "x" : 1302, "y" : 677 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1420, "y" : 690 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1420, "y" : 690 } } }, "connectors" : [ { "edgeId" : 62342, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 62347, "reactomeId" : 10294420, "displayName" : "KLRF1 dimer", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 1775, "y" : 707 }, "minX" : 1747, "maxX" : 1809, "minY" : 657, "maxY" : 725, "prop" : { "x" : 1747, "y" : 689, "width" : 56, "height" : 36 }, "textPosition" : { "x" : 1751, "y" : 690 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1803, "y" : 689 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1803, "y" : 689 } } }, "connectors" : [ { "edgeId" : 62346, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1784, "y" : 686 }, "to" : { "x" : 1801, "y" : 657 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 62348, "reactomeId" : 10294426, "displayName" : "CLEC2B dimer", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 1772, "y" : 584 }, "minX" : 1739, "maxX" : 1812, "minY" : 561, "maxY" : 657, "prop" : { "x" : 1739, "y" : 567, "width" : 67, "height" : 35 }, "textPosition" : { "x" : 1743, "y" : 567 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1806, "y" : 567 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1806, "y" : 567 } } }, "connectors" : [ { "edgeId" : 62346, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1778, "y" : 605 }, "to" : { "x" : 1801, "y" : 657 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 62349, "reactomeId" : 10294428, "displayName" : "KLRF1 dimer:CLEC2B dimer", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 1872, "y" : 584 }, "minX" : 1827, "maxX" : 1923, "minY" : 560, "maxY" : 602, "prop" : { "x" : 1827, "y" : 566, "width" : 90, "height" : 36 }, "textPosition" : { "x" : 1828, "y" : 553 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1917, "y" : 566 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1917, "y" : 566 } } }, "connectors" : [ { "edgeId" : 62346, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 62351, "reactomeId" : 10294356, "displayName" : "SLAMF7", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 1989, "y" : 344 }, "minX" : 1959, "maxX" : 2026, "minY" : 326, "maxY" : 396, "prop" : { "x" : 1959, "y" : 332, "width" : 61, "height" : 24 }, "textPosition" : { "x" : 1962, "y" : 333 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2020, "y" : 332 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2020, "y" : 332 } } }, "connectors" : [ { "edgeId" : 62350, "type" : "INPUT", "segments" : [ ], "stoichiometry" : { "value" : 2, "shape" : { "a" : { "x" : 1983, "y" : 384 }, "b" : { "x" : 1995, "y" : 396 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1989, "y" : 390 } } } } ] }, { "id" : 62352, "reactomeId" : 10294358, "displayName" : "SLAMF7 dimer", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 1990, "y" : 470 }, "minX" : 1956, "maxX" : 2031, "minY" : 447, "maxY" : 488, "prop" : { "x" : 1956, "y" : 453, "width" : 69, "height" : 35 }, "textPosition" : { "x" : 1961, "y" : 453 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2025, "y" : 453 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2025, "y" : 453 } } }, "connectors" : [ { "edgeId" : 62350, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 62354, "reactomeId" : 10294615, "displayName" : "Collagen type XVII fibril", "schemaClass" : "Polymer", "renderableClass" : "Entity", "position" : { "x" : 1753, "y" : 355 }, "minX" : 1703, "maxX" : 1803, "minY" : 337, "maxY" : 420, "prop" : { "x" : 1703, "y" : 337, "width" : 100, "height" : 37 }, "textPosition" : { "x" : 1704, "y" : 338 }, "connectors" : [ { "edgeId" : 62353, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1765, "y" : 377 }, "to" : { "x" : 1798, "y" : 420 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 62355, "reactomeId" : 10294619, "displayName" : "LAIR1", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 1795, "y" : 471 }, "minX" : 1771, "maxX" : 1826, "minY" : 420, "maxY" : 484, "prop" : { "x" : 1771, "y" : 459, "width" : 49, "height" : 25 }, "textPosition" : { "x" : 1775, "y" : 461 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1820, "y" : 459 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1820, "y" : 459 } } }, "connectors" : [ { "edgeId" : 62353, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1795, "y" : 456 }, "to" : { "x" : 1798, "y" : 420 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 62356, "reactomeId" : 10294621, "displayName" : "LAIR1:Collagen type XVII", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 1874, "y" : 355 }, "minX" : 1828, "maxX" : 1926, "minY" : 326, "maxY" : 379, "prop" : { "x" : 1828, "y" : 332, "width" : 92, "height" : 47 }, "textPosition" : { "x" : 1841, "y" : 330 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1920, "y" : 332 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1920, "y" : 332 } } }, "connectors" : [ { "edgeId" : 62353, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 62358, "reactomeId" : 5696348, "displayName" : "CERA,PE,PS", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 561, "y" : 823 }, "minX" : 522, "maxX" : 600, "minY" : 813, "maxY" : 879, "prop" : { "x" : 522, "y" : 813, "width" : 78, "height" : 21 }, "textPosition" : { "x" : 529, "y" : 806 }, "connectors" : [ { "edgeId" : 62357, "type" : "INPUT", "segments" : [ { "from" : { "x" : 567, "y" : 840 }, "to" : { "x" : 594, "y" : 879 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 62359, "reactomeId" : 10297366, "displayName" : "TREM, CD300", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 548, "y" : 931 }, "minX" : 510, "maxX" : 594, "minY" : 879, "maxY" : 949, "prop" : { "x" : 510, "y" : 913, "width" : 77, "height" : 36 }, "textPosition" : { "x" : 524, "y" : 913 }, "connectors" : [ { "edgeId" : 62357, "type" : "INPUT", "segments" : [ { "from" : { "x" : 563, "y" : 907 }, "to" : { "x" : 594, "y" : 879 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 62360, "reactomeId" : 10297368, "displayName" : "TRIM, CD300:lipids", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 673, "y" : 825 }, "minX" : 626, "maxX" : 726, "minY" : 802, "maxY" : 842, "prop" : { "x" : 626, "y" : 808, "width" : 94, "height" : 34 }, "textPosition" : { "x" : 628, "y" : 807 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 720, "y" : 808 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 720, "y" : 808 } } }, "connectors" : [ { "edgeId" : 62357, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 62362, "reactomeId" : 10243569, "displayName" : "T-cell receptor complex", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 1952, "y" : 140 }, "minX" : 1807, "maxX" : 2005, "minY" : 110, "maxY" : 204, "prop" : { "x" : 1906, "y" : 116, "width" : 93, "height" : 48 }, "textPosition" : { "x" : 1919, "y" : 115 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1999, "y" : 116 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1999, "y" : 116 } } }, "connectors" : [ { "edgeId" : 62361, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1920, "y" : 167 }, "to" : { "x" : 1877, "y" : 197 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 62365, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1903, "y" : 160 }, "to" : { "x" : 1807, "y" : 204 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 62363, "reactomeId" : 10306799, "displayName" : "CD1:B2M:microbial lipid", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 1982, "y" : 243 }, "minX" : 1877, "maxX" : 2019, "minY" : 197, "maxY" : 264, "prop" : { "x" : 1946, "y" : 223, "width" : 73, "height" : 41 }, "textPosition" : { "x" : 1948, "y" : 219 }, "connectors" : [ { "edgeId" : 62361, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1940, "y" : 227 }, "to" : { "x" : 1877, "y" : 197 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 62364, "reactomeId" : 10306801, "displayName" : "CD1:B2M:microbial lipid:TCR", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 1795, "y" : 144 }, "minX" : 1749, "maxX" : 1847, "minY" : 115, "maxY" : 167, "prop" : { "x" : 1749, "y" : 121, "width" : 92, "height" : 46 }, "textPosition" : { "x" : 1761, "y" : 118 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1841, "y" : 121 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1841, "y" : 121 } } }, "connectors" : [ { "edgeId" : 62361, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 62366, "reactomeId" : 10306781, "displayName" : "CD1:B2M:self-lipid", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 1840, "y" : 243 }, "minX" : 1801, "maxX" : 1880, "minY" : 204, "maxY" : 266, "prop" : { "x" : 1801, "y" : 220, "width" : 79, "height" : 46 }, "textPosition" : { "x" : 1807, "y" : 225 }, "connectors" : [ { "edgeId" : 62365, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1820, "y" : 214 }, "to" : { "x" : 1807, "y" : 204 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 62367, "reactomeId" : 10306783, "displayName" : "CD1:B2M:self-lipid:TCR", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 1681, "y" : 143 }, "minX" : 1636, "maxX" : 1732, "minY" : 118, "maxY" : 163, "prop" : { "x" : 1636, "y" : 124, "width" : 90, "height" : 39 }, "textPosition" : { "x" : 1638, "y" : 128 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1726, "y" : 124 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1726, "y" : 124 } } }, "connectors" : [ { "edgeId" : 62365, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 62369, "reactomeId" : 10308418, "displayName" : "PILRA", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 932, "y" : 818 }, "minX" : 911, "maxX" : 988, "minY" : 801, "maxY" : 877, "prop" : { "x" : 911, "y" : 807, "width" : 42, "height" : 22 }, "textPosition" : { "x" : 911, "y" : 807 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 953, "y" : 807 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 953, "y" : 807 } } }, "connectors" : [ { "edgeId" : 62368, "type" : "INPUT", "segments" : [ { "from" : { "x" : 942, "y" : 832 }, "to" : { "x" : 988, "y" : 877 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 62370, "reactomeId" : 10308456, "displayName" : "PIANP,NPDC1,CLEC4G,COLEC12 trimer", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 965, "y" : 931 }, "minX" : 907, "maxX" : 1024, "minY" : 877, "maxY" : 956, "prop" : { "x" : 907, "y" : 906, "width" : 117, "height" : 50 }, "textPosition" : { "x" : 907, "y" : 906 }, "connectors" : [ { "edgeId" : 62368, "type" : "INPUT", "segments" : [ { "from" : { "x" : 975, "y" : 900 }, "to" : { "x" : 988, "y" : 877 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 62371, "reactomeId" : 10308458, "displayName" : "PILRA:PIANP,NPDC1,CLEC4G,COLEC12 trimer", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 1095, "y" : 933 }, "minX" : 1044, "maxX" : 1153, "minY" : 900, "maxY" : 960, "prop" : { "x" : 1044, "y" : 906, "width" : 103, "height" : 54 }, "textPosition" : { "x" : 1053, "y" : 883 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1147, "y" : 906 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1147, "y" : 906 } } }, "connectors" : [ { "edgeId" : 62368, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 62373, "reactomeId" : 10308438, "displayName" : "Homologues of CD99", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 744, "y" : 932 }, "minX" : 718, "maxX" : 787, "minY" : 878, "maxY" : 943, "prop" : { "x" : 718, "y" : 921, "width" : 52, "height" : 22 }, "textPosition" : { "x" : 718, "y" : 901 }, "connectors" : [ { "edgeId" : 62372, "type" : "INPUT", "segments" : [ { "from" : { "x" : 752, "y" : 918 }, "to" : { "x" : 787, "y" : 878 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 62374, "reactomeId" : 10308428, "displayName" : "PILRA,PILRB", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 778, "y" : 819 }, "minX" : 740, "maxX" : 816, "minY" : 806, "maxY" : 878, "prop" : { "x" : 740, "y" : 806, "width" : 76, "height" : 27 }, "textPosition" : { "x" : 755, "y" : 802 }, "connectors" : [ { "edgeId" : 62372, "type" : "INPUT", "segments" : [ { "from" : { "x" : 780, "y" : 839 }, "to" : { "x" : 787, "y" : 878 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 62375, "reactomeId" : 10308440, "displayName" : "PILRA,PILRB:CD99", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 839, "y" : 930 }, "minX" : 791, "maxX" : 893, "minY" : 907, "maxY" : 947, "prop" : { "x" : 791, "y" : 913, "width" : 96, "height" : 34 }, "textPosition" : { "x" : 798, "y" : 912 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 887, "y" : 913 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 887, "y" : 913 } } }, "connectors" : [ { "edgeId" : 62372, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 62377, "reactomeId" : 9679737, "displayName" : "natalizumab", "schemaClass" : "ProteinDrug", "renderableClass" : "ProteinDrug", "position" : { "x" : 52, "y" : 12 }, "minX" : 0, "maxX" : 108, "minY" : 0, "maxY" : 43, "prop" : { "x" : 0, "y" : 0, "width" : 105, "height" : 24 }, "textPosition" : { "x" : 11, "y" : 1 }, "bgColor" : { "r" : 184, "g" : 154, "b" : 230 }, "fgColor" : { "r" : 161, "g" : 1, "b" : 2 }, "connectors" : [ { "edgeId" : 62376, "type" : "INPUT", "segments" : [ { "from" : { "x" : 73, "y" : 27 }, "to" : { "x" : 108, "y" : 43 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 62382, "reactomeId" : 10243577, "displayName" : "HLA-C Cw4 (group 2)", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 637, "y" : 139 }, "minX" : 593, "maxX" : 687, "minY" : 117, "maxY" : 155, "prop" : { "x" : 593, "y" : 123, "width" : 88, "height" : 32 }, "textPosition" : { "x" : 599, "y" : 120 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 681, "y" : 123 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 681, "y" : 123 } } }, "connectors" : [ ] }, { "id" : 62385, "reactomeId" : 10297332, "displayName" : "Collagen types I,II,III/SP-D", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 155, "y" : 916 }, "minX" : 100, "maxX" : 210, "minY" : 898, "maxY" : 934, "prop" : { "x" : 100, "y" : 898, "width" : 110, "height" : 36 }, "textPosition" : { "x" : 103, "y" : 898 }, "connectors" : [ ] }, { "id" : 62387, "reactomeId" : 10249769, "displayName" : "Collagen type III fibril", "schemaClass" : "Polymer", "renderableClass" : "EntitySet", "position" : { "x" : 292, "y" : 919 }, "minX" : 232, "maxX" : 352, "minY" : 907, "maxY" : 931, "prop" : { "x" : 232, "y" : 907, "width" : 120, "height" : 24 }, "textPosition" : { "x" : 237, "y" : 902 }, "connectors" : [ ] }, { "id" : 62277, "reactomeId" : 10243428, "displayName" : "ITGA4:ITGB1", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 97, "y" : 142 }, "minX" : 54, "maxX" : 147, "minY" : 43, "maxY" : 181, "prop" : { "x" : 54, "y" : 130, "width" : 87, "height" : 24 }, "textPosition" : { "x" : 56, "y" : 133 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 141, "y" : 130 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 141, "y" : 130 } } }, "connectors" : [ { "edgeId" : 62276, "type" : "INPUT", "segments" : [ { "from" : { "x" : 106, "y" : 157 }, "to" : { "x" : 128, "y" : 181 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 62376, "type" : "INPUT", "segments" : [ { "from" : { "x" : 98, "y" : 127 }, "to" : { "x" : 108, "y" : 43 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 62278, "reactomeId" : 10243432, "displayName" : "VCAM1", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 109, "y" : 244 }, "minX" : 79, "maxX" : 146, "minY" : 181, "maxY" : 255, "prop" : { "x" : 79, "y" : 233, "width" : 61, "height" : 22 }, "textPosition" : { "x" : 84, "y" : 233 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 140, "y" : 233 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 140, "y" : 233 } } }, "connectors" : [ { "edgeId" : 62276, "type" : "INPUT", "segments" : [ { "from" : { "x" : 112, "y" : 230 }, "to" : { "x" : 128, "y" : 181 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 62279, "reactomeId" : 10243434, "displayName" : "integrin alpha4beta1:VCAM1", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 275, "y" : 244 }, "minX" : 221, "maxX" : 335, "minY" : 213, "maxY" : 269, "prop" : { "x" : 221, "y" : 219, "width" : 108, "height" : 50 }, "textPosition" : { "x" : 229, "y" : 220 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 329, "y" : 219 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 329, "y" : 219 } } }, "connectors" : [ { "edgeId" : 62276, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 62280, "reactomeId" : 10243436, "displayName" : "ITGA4:ITGB1:natalizumab", "schemaClass" : "Complex", "renderableClass" : "ComplexDrug", "position" : { "x" : 177, "y" : 83 }, "minX" : 127, "maxX" : 234, "minY" : 59, "maxY" : 171, "prop" : { "x" : 127, "y" : 65, "width" : 101, "height" : 36 }, "textPosition" : { "x" : 134, "y" : 66 }, "bgColor" : { "r" : 184, "g" : 154, "b" : 230 }, "fgColor" : { "r" : 161, "g" : 1, "b" : 2 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 228, "y" : 65 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 228, "y" : 65 } } }, "connectors" : [ { "edgeId" : 62276, "type" : "INHIBITOR", "segments" : [ { "from" : { "x" : 177, "y" : 104 }, "to" : { "x" : 178, "y" : 171 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 174, "y" : 171 }, "b" : { "x" : 182, "y" : 171 }, "c" : { "x" : 178, "y" : 171 }, "type" : "STOP", "centre" : { "x" : 178, "y" : 171 } } }, { "edgeId" : 62376, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 62282, "reactomeId" : 10243571, "displayName" : "T-cell receptor complex with CD8", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 405, "y" : 135 }, "minX" : 346, "maxX" : 470, "minY" : 113, "maxY" : 195, "prop" : { "x" : 346, "y" : 119, "width" : 118, "height" : 32 }, "textPosition" : { "x" : 346, "y" : 116 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 464, "y" : 119 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 464, "y" : 119 } } }, "connectors" : [ { "edgeId" : 62281, "type" : "INPUT", "segments" : [ { "from" : { "x" : 397, "y" : 154 }, "to" : { "x" : 375, "y" : 195 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 62283, "reactomeId" : 10243507, "displayName" : "Antigen peptide bound class I MHC", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 409, "y" : 244 }, "minX" : 347, "maxX" : 478, "minY" : 195, "maxY" : 262, "prop" : { "x" : 347, "y" : 226, "width" : 125, "height" : 36 }, "textPosition" : { "x" : 348, "y" : 227 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 472, "y" : 226 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 472, "y" : 226 } } }, "connectors" : [ { "edgeId" : 62281, "type" : "INPUT", "segments" : [ { "from" : { "x" : 396, "y" : 223 }, "to" : { "x" : 375, "y" : 195 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 62284, "reactomeId" : 10243573, "displayName" : "TCR interacting with antigen-bearing MHC Class I", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 263, "y" : 145 }, "minX" : 198, "maxX" : 334, "minY" : 111, "maxY" : 174, "prop" : { "x" : 198, "y" : 117, "width" : 130, "height" : 57 }, "textPosition" : { "x" : 199, "y" : 111 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 328, "y" : 117 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 328, "y" : 117 } } }, "connectors" : [ { "edgeId" : 62281, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 62286, "reactomeId" : 10243589, "displayName" : "NKG2D ligand", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 1062, "y" : 584 }, "minX" : 1030, "maxX" : 1095, "minY" : 569, "maxY" : 654, "prop" : { "x" : 1030, "y" : 569, "width" : 65, "height" : 31 }, "textPosition" : { "x" : 1035, "y" : 567 }, "connectors" : [ { "edgeId" : 62285, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1057, "y" : 606 }, "to" : { "x" : 1043, "y" : 654 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 62287, "reactomeId" : 10243599, "displayName" : "NKG2D complexed with DAP10", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 1068, "y" : 709 }, "minX" : 1020, "maxX" : 1123, "minY" : 654, "maxY" : 732, "prop" : { "x" : 1020, "y" : 686, "width" : 97, "height" : 46 }, "textPosition" : { "x" : 1029, "y" : 683 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1117, "y" : 686 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1117, "y" : 686 } } }, "connectors" : [ { "edgeId" : 62285, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1057, "y" : 683 }, "to" : { "x" : 1043, "y" : 654 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 62288, "reactomeId" : 10243601, "displayName" : "Ligand interacting with NKG2D", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 956, "y" : 578 }, "minX" : 900, "maxX" : 1018, "minY" : 547, "maxY" : 604, "prop" : { "x" : 900, "y" : 553, "width" : 112, "height" : 51 }, "textPosition" : { "x" : 901, "y" : 555 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1012, "y" : 553 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1012, "y" : 553 } } }, "connectors" : [ { "edgeId" : 62285, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 62290, "reactomeId" : 10243611, "displayName" : "CD96", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 841, "y" : 242 }, "minX" : 818, "maxX" : 875, "minY" : 185, "maxY" : 253, "prop" : { "x" : 818, "y" : 231, "width" : 46, "height" : 22 }, "textPosition" : { "x" : 820, "y" : 231 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 864, "y" : 231 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 864, "y" : 231 } } }, "connectors" : [ { "edgeId" : 62289, "type" : "INPUT", "segments" : [ { "from" : { "x" : 847, "y" : 228 }, "to" : { "x" : 875, "y" : 185 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 62291, "reactomeId" : 10243607, "displayName" : "PVR", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 913, "y" : 139 }, "minX" : 875, "maxX" : 946, "minY" : 122, "maxY" : 189, "prop" : { "x" : 895, "y" : 128, "width" : 37, "height" : 22 }, "textPosition" : { "x" : 897, "y" : 128 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 932, "y" : 128 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 932, "y" : 128 } } }, "connectors" : [ { "edgeId" : 62289, "type" : "INPUT", "segments" : [ { "from" : { "x" : 903, "y" : 153 }, "to" : { "x" : 875, "y" : 185 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 62309, "type" : "INPUT", "segments" : [ { "from" : { "x" : 920, "y" : 153 }, "to" : { "x" : 946, "y" : 189 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 62292, "reactomeId" : 10243613, "displayName" : "CD96:PVR", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 844, "y" : 141 }, "minX" : 804, "maxX" : 890, "minY" : 124, "maxY" : 152, "prop" : { "x" : 804, "y" : 130, "width" : 80, "height" : 22 }, "textPosition" : { "x" : 809, "y" : 131 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 884, "y" : 130 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 884, "y" : 130 } } }, "connectors" : [ { "edgeId" : 62289, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 62294, "reactomeId" : 10243621, "displayName" : "Integrin alpha4beta7", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 1370, "y" : 138 }, "minX" : 1319, "maxX" : 1428, "minY" : 114, "maxY" : 195, "prop" : { "x" : 1319, "y" : 120, "width" : 103, "height" : 36 }, "textPosition" : { "x" : 1326, "y" : 121 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1422, "y" : 120 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1422, "y" : 120 } } }, "connectors" : [ { "edgeId" : 62293, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1359, "y" : 159 }, "to" : { "x" : 1337, "y" : 195 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 62295, "reactomeId" : 10243625, "displayName" : "MADCAM1", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 1381, "y" : 246 }, "minX" : 1330, "maxX" : 1439, "minY" : 195, "maxY" : 257, "prop" : { "x" : 1330, "y" : 235, "width" : 103, "height" : 22 }, "textPosition" : { "x" : 1347, "y" : 235 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1433, "y" : 235 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1433, "y" : 235 } } }, "connectors" : [ { "edgeId" : 62293, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1371, "y" : 232 }, "to" : { "x" : 1337, "y" : 195 } } ], "stoichiometry" : { "value" : 2, "shape" : { "a" : { "x" : 1348, "y" : 207 }, "b" : { "x" : 1360, "y" : 219 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1354, "y" : 213 } } } } ] }, { "id" : 62296, "reactomeId" : 10243627, "displayName" : "Integrin alpha4beta7:MADCAM1", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 1247, "y" : 139 }, "minX" : 1193, "maxX" : 1307, "minY" : 108, "maxY" : 164, "prop" : { "x" : 1193, "y" : 114, "width" : 108, "height" : 50 }, "textPosition" : { "x" : 1201, "y" : 115 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1301, "y" : 114 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1301, "y" : 114 } } }, "connectors" : [ { "edgeId" : 62293, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 62298, "reactomeId" : 10243799, "displayName" : "L-selectin ligands", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 150, "y" : 352 }, "minX" : 103, "maxX" : 203, "minY" : 334, "maxY" : 414, "prop" : { "x" : 103, "y" : 334, "width" : 94, "height" : 36 }, "textPosition" : { "x" : 114, "y" : 334 }, "connectors" : [ { "edgeId" : 62297, "type" : "INPUT", "segments" : [ { "from" : { "x" : 165, "y" : 376 }, "to" : { "x" : 203, "y" : 414 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 62299, "reactomeId" : 10243793, "displayName" : "SELL", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 169, "y" : 465 }, "minX" : 146, "maxX" : 203, "minY" : 414, "maxY" : 476, "prop" : { "x" : 146, "y" : 454, "width" : 46, "height" : 22 }, "textPosition" : { "x" : 151, "y" : 454 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 192, "y" : 454 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 192, "y" : 454 } } }, "connectors" : [ { "edgeId" : 62297, "type" : "INPUT", "segments" : [ { "from" : { "x" : 176, "y" : 451 }, "to" : { "x" : 203, "y" : 414 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 62300, "reactomeId" : 10243801, "displayName" : "L-selectin interacting with known ligands", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 281, "y" : 355 }, "minX" : 218, "maxX" : 351, "minY" : 324, "maxY" : 380, "prop" : { "x" : 218, "y" : 330, "width" : 127, "height" : 50 }, "textPosition" : { "x" : 227, "y" : 331 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 345, "y" : 330 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 345, "y" : 330 } } }, "connectors" : [ { "edgeId" : 62297, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 62302, "reactomeId" : 10243835, "displayName" : "Integrin alphaLbeta2", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 411, "y" : 352 }, "minX" : 360, "maxX" : 469, "minY" : 328, "maxY" : 425, "prop" : { "x" : 360, "y" : 334, "width" : 103, "height" : 36 }, "textPosition" : { "x" : 368, "y" : 335 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 463, "y" : 334 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 463, "y" : 334 } } }, "connectors" : [ { "edgeId" : 62301, "type" : "INPUT", "segments" : [ { "from" : { "x" : 405, "y" : 373 }, "to" : { "x" : 387, "y" : 425 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 62303, "reactomeId" : 10243825, "displayName" : "ICAM 1-5", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 407, "y" : 467 }, "minX" : 367, "maxX" : 447, "minY" : 425, "maxY" : 478, "prop" : { "x" : 367, "y" : 456, "width" : 80, "height" : 22 }, "textPosition" : { "x" : 376, "y" : 456 }, "connectors" : [ { "edgeId" : 62301, "type" : "INPUT", "segments" : [ { "from" : { "x" : 401, "y" : 450 }, "to" : { "x" : 387, "y" : 425 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 62304, "reactomeId" : 10243837, "displayName" : "LFA-1:ICAM 1-5", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 290, "y" : 464 }, "minX" : 238, "maxX" : 349, "minY" : 446, "maxY" : 477, "prop" : { "x" : 238, "y" : 452, "width" : 105, "height" : 25 }, "textPosition" : { "x" : 241, "y" : 456 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 343, "y" : 452 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 343, "y" : 452 } } }, "connectors" : [ { "edgeId" : 62301, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 62306, "reactomeId" : 10243859, "displayName" : "NECTIN2", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 1106, "y" : 141 }, "minX" : 1010, "maxX" : 1182, "minY" : 124, "maxY" : 208, "prop" : { "x" : 1078, "y" : 130, "width" : 56, "height" : 22 }, "textPosition" : { "x" : 1080, "y" : 124 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1134, "y" : 130 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1134, "y" : 130 } } }, "connectors" : [ { "edgeId" : 62305, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1120, "y" : 155 }, "to" : { "x" : 1182, "y" : 200 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 62312, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1090, "y" : 155 }, "to" : { "x" : 1010, "y" : 208 } } ], "stoichiometry" : { "value" : 2, "shape" : { "a" : { "x" : 1044, "y" : 175 }, "b" : { "x" : 1056, "y" : 187 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1050, "y" : 181 } } } } ] }, { "id" : 62307, "reactomeId" : 10243855, "displayName" : "CRTAM", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 1152, "y" : 244 }, "minX" : 1122, "maxX" : 1189, "minY" : 200, "maxY" : 255, "prop" : { "x" : 1122, "y" : 233, "width" : 61, "height" : 22 }, "textPosition" : { "x" : 1128, "y" : 233 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1183, "y" : 233 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1183, "y" : 233 } } }, "connectors" : [ { "edgeId" : 62305, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1159, "y" : 230 }, "to" : { "x" : 1182, "y" : 200 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 62308, "reactomeId" : 10243861, "displayName" : "CRTAM bound to NECL2", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 1259, "y" : 242 }, "minX" : 1213, "maxX" : 1312, "minY" : 218, "maxY" : 260, "prop" : { "x" : 1213, "y" : 224, "width" : 93, "height" : 36 }, "textPosition" : { "x" : 1211, "y" : 225 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1306, "y" : 224 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1306, "y" : 224 } } }, "connectors" : [ { "edgeId" : 62305, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 62310, "reactomeId" : 10243867, "displayName" : "CD226", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 915, "y" : 245 }, "minX" : 887, "maxX" : 1010, "minY" : 189, "maxY" : 256, "prop" : { "x" : 887, "y" : 234, "width" : 56, "height" : 22 }, "textPosition" : { "x" : 890, "y" : 234 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 943, "y" : 234 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 943, "y" : 234 } } }, "connectors" : [ { "edgeId" : 62309, "type" : "INPUT", "segments" : [ { "from" : { "x" : 921, "y" : 231 }, "to" : { "x" : 946, "y" : 189 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 62312, "type" : "INPUT", "segments" : [ { "from" : { "x" : 946, "y" : 234 }, "to" : { "x" : 1010, "y" : 208 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 62311, "reactomeId" : 10243869, "displayName" : "CD226:PVR", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 996, "y" : 143 }, "minX" : 952, "maxX" : 1047, "minY" : 126, "maxY" : 154, "prop" : { "x" : 952, "y" : 132, "width" : 89, "height" : 22 }, "textPosition" : { "x" : 958, "y" : 133 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1041, "y" : 132 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1041, "y" : 132 } } }, "connectors" : [ { "edgeId" : 62309, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 62313, "reactomeId" : 10243873, "displayName" : "CD226 bound to Nectin 2", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 1052, "y" : 248 }, "minX" : 999, "maxX" : 1111, "minY" : 225, "maxY" : 265, "prop" : { "x" : 999, "y" : 231, "width" : 106, "height" : 34 }, "textPosition" : { "x" : 1003, "y" : 230 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1105, "y" : 231 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1105, "y" : 231 } } }, "connectors" : [ { "edgeId" : 62312, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 62315, "reactomeId" : 10243883, "displayName" : "CD200", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 925, "y" : 460 }, "minX" : 891, "maxX" : 959, "minY" : 407, "maxY" : 471, "prop" : { "x" : 897, "y" : 449, "width" : 56, "height" : 22 }, "textPosition" : { "x" : 900, "y" : 449 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 953, "y" : 449 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 953, "y" : 449 } } }, "connectors" : [ { "edgeId" : 62314, "type" : "INPUT", "segments" : [ { "from" : { "x" : 917, "y" : 446 }, "to" : { "x" : 891, "y" : 407 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 62316, "reactomeId" : 10243879, "displayName" : "CD200R1", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 920, "y" : 353 }, "minX" : 883, "maxX" : 964, "minY" : 336, "maxY" : 407, "prop" : { "x" : 883, "y" : 342, "width" : 75, "height" : 22 }, "textPosition" : { "x" : 888, "y" : 342 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 958, "y" : 342 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 958, "y" : 342 } } }, "connectors" : [ { "edgeId" : 62314, "type" : "INPUT", "segments" : [ { "from" : { "x" : 914, "y" : 367 }, "to" : { "x" : 891, "y" : 407 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 62317, "reactomeId" : 10243885, "displayName" : "CD200 bound to CD200R", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 816, "y" : 352 }, "minX" : 757, "maxX" : 881, "minY" : 329, "maxY" : 369, "prop" : { "x" : 757, "y" : 335, "width" : 118, "height" : 34 }, "textPosition" : { "x" : 759, "y" : 334 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 875, "y" : 335 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 875, "y" : 335 } } }, "connectors" : [ { "edgeId" : 62314, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 62319, "reactomeId" : 10243891, "displayName" : "CD160", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 1038, "y" : 357 }, "minX" : 1010, "maxX" : 1079, "minY" : 340, "maxY" : 405, "prop" : { "x" : 1010, "y" : 346, "width" : 56, "height" : 22 }, "textPosition" : { "x" : 1013, "y" : 346 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1066, "y" : 346 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1066, "y" : 346 } } }, "connectors" : [ { "edgeId" : 62318, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1047, "y" : 371 }, "to" : { "x" : 1079, "y" : 405 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 62320, "reactomeId" : 10243893, "displayName" : "MHC Class I molecules interacting with CD160", "schemaClass" : "CandidateSet", "renderableClass" : "EntitySet", "position" : { "x" : 1030, "y" : 459 }, "minX" : 967, "maxX" : 1094, "minY" : 405, "maxY" : 491, "prop" : { "x" : 967, "y" : 427, "width" : 127, "height" : 64 }, "textPosition" : { "x" : 976, "y" : 427 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "connectors" : [ { "edgeId" : 62318, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1059, "y" : 421 }, "to" : { "x" : 1079, "y" : 405 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 62321, "reactomeId" : 10243895, "displayName" : "MHC Class I interacting with CD160", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 1175, "y" : 454 }, "minX" : 1126, "maxX" : 1231, "minY" : 425, "maxY" : 477, "prop" : { "x" : 1126, "y" : 431, "width" : 99, "height" : 46 }, "textPosition" : { "x" : 1134, "y" : 428 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1225, "y" : 431 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1225, "y" : 431 } } }, "connectors" : [ { "edgeId" : 62318, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 62323, "reactomeId" : 10243993, "displayName" : "CD40LG trimer", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 1423, "y" : 353 }, "minX" : 1384, "maxX" : 1469, "minY" : 331, "maxY" : 422, "prop" : { "x" : 1384, "y" : 337, "width" : 79, "height" : 33 }, "textPosition" : { "x" : 1393, "y" : 335 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1463, "y" : 337 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1463, "y" : 337 } } }, "connectors" : [ { "edgeId" : 62322, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1425, "y" : 373 }, "to" : { "x" : 1433, "y" : 422 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 62324, "reactomeId" : 10243999, "displayName" : "CD40 trimer", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 1420, "y" : 463 }, "minX" : 1373, "maxX" : 1473, "minY" : 422, "maxY" : 474, "prop" : { "x" : 1373, "y" : 452, "width" : 94, "height" : 22 }, "textPosition" : { "x" : 1379, "y" : 453 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1467, "y" : 452 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1467, "y" : 452 } } }, "connectors" : [ { "edgeId" : 62322, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1423, "y" : 449 }, "to" : { "x" : 1433, "y" : 422 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 62325, "reactomeId" : 10244001, "displayName" : "CD40:CD40L trimer", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 1543, "y" : 458 }, "minX" : 1492, "maxX" : 1601, "minY" : 434, "maxY" : 476, "prop" : { "x" : 1492, "y" : 440, "width" : 103, "height" : 36 }, "textPosition" : { "x" : 1499, "y" : 441 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1595, "y" : 440 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1595, "y" : 440 } } }, "connectors" : [ { "edgeId" : 62322, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 62327, "reactomeId" : 10243847, "displayName" : "JAML", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 1717, "y" : 474 }, "minX" : 1637, "maxX" : 1756, "minY" : 412, "maxY" : 485, "prop" : { "x" : 1685, "y" : 463, "width" : 65, "height" : 22 }, "textPosition" : { "x" : 1700, "y" : 463 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1750, "y" : 463 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1750, "y" : 463 } } }, "connectors" : [ { "edgeId" : 62326, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1702, "y" : 460 }, "to" : { "x" : 1637, "y" : 412 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 62328, "reactomeId" : 10243843, "displayName" : "CXADR", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 1657, "y" : 355 }, "minX" : 1629, "maxX" : 1691, "minY" : 338, "maxY" : 412, "prop" : { "x" : 1629, "y" : 344, "width" : 56, "height" : 22 }, "textPosition" : { "x" : 1633, "y" : 344 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1685, "y" : 344 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1685, "y" : 344 } } }, "connectors" : [ { "edgeId" : 62326, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1653, "y" : 369 }, "to" : { "x" : 1637, "y" : 412 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 62329, "reactomeId" : 10243849, "displayName" : "CXADR bound to JAML", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 1547, "y" : 353 }, "minX" : 1492, "maxX" : 1609, "minY" : 329, "maxY" : 371, "prop" : { "x" : 1492, "y" : 335, "width" : 111, "height" : 36 }, "textPosition" : { "x" : 1491, "y" : 336 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1603, "y" : 335 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1603, "y" : 335 } } }, "connectors" : [ { "edgeId" : 62326, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 62331, "reactomeId" : 10244086, "displayName" : "Complex of CD19, CD81, CD225 and CD21", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 134, "y" : 590 }, "minX" : 83, "maxX" : 192, "minY" : 552, "maxY" : 654, "prop" : { "x" : 83, "y" : 558, "width" : 103, "height" : 64 }, "textPosition" : { "x" : 89, "y" : 559 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 186, "y" : 558 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 186, "y" : 558 } } }, "connectors" : [ { "edgeId" : 62330, "type" : "INPUT", "segments" : [ { "from" : { "x" : 152, "y" : 625 }, "to" : { "x" : 171, "y" : 654 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 62332, "reactomeId" : 10244024, "displayName" : "C3d complexed with antigen", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 138, "y" : 707 }, "minX" : 97, "maxX" : 185, "minY" : 654, "maxY" : 731, "prop" : { "x" : 97, "y" : 683, "width" : 82, "height" : 48 }, "textPosition" : { "x" : 98, "y" : 668 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 179, "y" : 683 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 179, "y" : 683 } } }, "connectors" : [ { "edgeId" : 62330, "type" : "INPUT", "segments" : [ { "from" : { "x" : 152, "y" : 680 }, "to" : { "x" : 171, "y" : 654 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 62333, "reactomeId" : 10244088, "displayName" : "Complex of CD19, CD81, CD225 and CD21 with C3d-bound Antigen", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 254, "y" : 706 }, "minX" : 198, "maxX" : 317, "minY" : 663, "maxY" : 743, "prop" : { "x" : 198, "y" : 669, "width" : 113, "height" : 74 }, "textPosition" : { "x" : 203, "y" : 666 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 311, "y" : 669 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 311, "y" : 669 } } }, "connectors" : [ { "edgeId" : 62330, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 62335, "reactomeId" : 10294372, "displayName" : "KLRB1 dimer", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 1146, "y" : 583 }, "minX" : 1118, "maxX" : 1181, "minY" : 561, "maxY" : 646, "prop" : { "x" : 1118, "y" : 567, "width" : 57, "height" : 33 }, "textPosition" : { "x" : 1122, "y" : 565 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1175, "y" : 567 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1175, "y" : 567 } } }, "connectors" : [ { "edgeId" : 62334, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1153, "y" : 603 }, "to" : { "x" : 1174, "y" : 646 } } ], "stoichiometry" : { "value" : 1 } } ] } ], "edges" : [ { "id" : 62338, "reactomeId" : 10294414, "displayName" : "Sialic acid binds SIGLEC", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 1335, "y" : 664 }, "minX" : 1296, "maxX" : 1383, "minY" : 610, "maxY" : 670, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 1296, "y" : 664 }, "to" : { "x" : 1335, "y" : 664 } }, { "from" : { "x" : 1335, "y" : 664 }, "to" : { "x" : 1383, "y" : 610 } } ], "endShape" : { "a" : { "x" : 1381, "y" : 618 }, "b" : { "x" : 1383, "y" : 610 }, "c" : { "x" : 1375, "y" : 613 }, "type" : "ARROW", "centre" : { "x" : 1375, "y" : 613 } }, "reactionShape" : { "c" : { "x" : 1335, "y" : 664 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 1335, "y" : 664 } }, "inputs" : [ { "id" : 62339, "points" : [ { "x" : 1313, "y" : 603 } ] }, { "id" : 62340, "points" : [ { "x" : 1260, "y" : 692 } ] } ], "outputs" : [ { "id" : 62341 } ] }, { "id" : 62276, "reactomeId" : 10243438, "displayName" : "VCAM1 binds Integrin alpha4beta1", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 178, "y" : 180 }, "minX" : 128, "maxX" : 237, "minY" : 174, "maxY" : 216, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 128, "y" : 181 }, "to" : { "x" : 178, "y" : 180 } }, { "from" : { "x" : 178, "y" : 180 }, "to" : { "x" : 237, "y" : 216 } } ], "endShape" : { "a" : { "x" : 229, "y" : 216 }, "b" : { "x" : 237, "y" : 216 }, "c" : { "x" : 233, "y" : 209 }, "type" : "ARROW", "centre" : { "x" : 233, "y" : 209 } }, "reactionShape" : { "c" : { "x" : 178, "y" : 180 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 178, "y" : 180 } }, "inputs" : [ { "id" : 62277, "points" : [ { "x" : 106, "y" : 157 } ] }, { "id" : 62278, "points" : [ { "x" : 112, "y" : 230 } ] } ], "outputs" : [ { "id" : 62279 } ], "inhibitors" : [ { "id" : 62280, "points" : [ { "x" : 177, "y" : 104 } ] } ] }, { "id" : 62342, "reactomeId" : 10294352, "displayName" : "NCR3LG1 binds NCR3", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 1421, "y" : 655 }, "minX" : 1377, "maxX" : 1452, "minY" : 649, "maxY" : 687, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 1452, "y" : 655 }, "to" : { "x" : 1421, "y" : 655 } }, { "from" : { "x" : 1421, "y" : 655 }, "to" : { "x" : 1377, "y" : 687 } } ], "endShape" : { "a" : { "x" : 1380, "y" : 680 }, "b" : { "x" : 1377, "y" : 687 }, "c" : { "x" : 1385, "y" : 686 }, "type" : "ARROW", "centre" : { "x" : 1385, "y" : 686 } }, "reactionShape" : { "c" : { "x" : 1421, "y" : 655 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 1421, "y" : 655 } }, "inputs" : [ { "id" : 62343, "points" : [ { "x" : 1478, "y" : 598 } ] }, { "id" : 62344, "points" : [ { "x" : 1485, "y" : 683 } ] } ], "outputs" : [ { "id" : 62345 } ] }, { "id" : 62281, "reactomeId" : 10243575, "displayName" : "TCR complex interacts with peptide antigen-presenting MHC Class I", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 341, "y" : 195 }, "minX" : 307, "maxX" : 375, "minY" : 177, "maxY" : 201, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 375, "y" : 195 }, "to" : { "x" : 341, "y" : 195 } }, { "from" : { "x" : 341, "y" : 195 }, "to" : { "x" : 307, "y" : 177 } } ], "endShape" : { "a" : { "x" : 315, "y" : 177 }, "b" : { "x" : 307, "y" : 177 }, "c" : { "x" : 311, "y" : 184 }, "type" : "ARROW", "centre" : { "x" : 311, "y" : 184 } }, "reactionShape" : { "c" : { "x" : 341, "y" : 195 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 341, "y" : 195 } }, "inputs" : [ { "id" : 62282, "points" : [ { "x" : 397, "y" : 154 } ] }, { "id" : 62283, "points" : [ { "x" : 396, "y" : 223 } ] } ], "outputs" : [ { "id" : 62284 } ] }, { "id" : 62346, "reactomeId" : 10294430, "displayName" : "CLEC2B binds KLRF1 dimer", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 1846, "y" : 656 }, "minX" : 1801, "maxX" : 1865, "minY" : 605, "maxY" : 662, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 1801, "y" : 657 }, "to" : { "x" : 1846, "y" : 656 } }, { "from" : { "x" : 1846, "y" : 656 }, "to" : { "x" : 1865, "y" : 605 } } ], "endShape" : { "a" : { "x" : 1866, "y" : 613 }, "b" : { "x" : 1865, "y" : 605 }, "c" : { "x" : 1859, "y" : 610 }, "type" : "ARROW", "centre" : { "x" : 1859, "y" : 610 } }, "reactionShape" : { "c" : { "x" : 1846, "y" : 656 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 1846, "y" : 656 } }, "inputs" : [ { "id" : 62347, "points" : [ { "x" : 1784, "y" : 686 } ] }, { "id" : 62348, "points" : [ { "x" : 1778, "y" : 605 } ] } ], "outputs" : [ { "id" : 62349 } ] }, { "id" : 62285, "reactomeId" : 10243603, "displayName" : "NKG2D homodimer interacting with ligands", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 1020, "y" : 654 }, "minX" : 977, "maxX" : 1043, "minY" : 607, "maxY" : 660, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 1043, "y" : 654 }, "to" : { "x" : 1020, "y" : 654 } }, { "from" : { "x" : 1020, "y" : 654 }, "to" : { "x" : 977, "y" : 607 } } ], "endShape" : { "a" : { "x" : 985, "y" : 609 }, "b" : { "x" : 977, "y" : 607 }, "c" : { "x" : 979, "y" : 615 }, "type" : "ARROW", "centre" : { "x" : 979, "y" : 615 } }, "reactionShape" : { "c" : { "x" : 1020, "y" : 654 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 1020, "y" : 654 } }, "inputs" : [ { "id" : 62286, "points" : [ { "x" : 1057, "y" : 606 } ] }, { "id" : 62287, "points" : [ { "x" : 1057, "y" : 683 } ] } ], "outputs" : [ { "id" : 62288 } ] }, { "id" : 62350, "reactomeId" : 10294360, "displayName" : "SLAMF7 binds SLAMF7", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 1989, "y" : 421 }, "minX" : 1983, "maxX" : 1995, "minY" : 359, "maxY" : 450, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 1989, "y" : 359 }, "to" : { "x" : 1989, "y" : 421 } }, { "from" : { "x" : 1989, "y" : 421 }, "to" : { "x" : 1989, "y" : 450 } } ], "endShape" : { "a" : { "x" : 1985, "y" : 443 }, "b" : { "x" : 1989, "y" : 450 }, "c" : { "x" : 1993, "y" : 443 }, "type" : "ARROW", "centre" : { "x" : 1993, "y" : 443 } }, "reactionShape" : { "c" : { "x" : 1989, "y" : 421 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 1989, "y" : 421 } }, "inputs" : [ { "id" : 62351, "stoichiometry" : 2 } ], "outputs" : [ { "id" : 62352 } ] }, { "id" : 62353, "reactomeId" : 10294623, "displayName" : "LAIR1 binds collagen", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 1828, "y" : 421 }, "minX" : 1798, "maxX" : 1857, "minY" : 382, "maxY" : 427, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 1798, "y" : 420 }, "to" : { "x" : 1828, "y" : 421 } }, { "from" : { "x" : 1828, "y" : 421 }, "to" : { "x" : 1857, "y" : 382 } } ], "endShape" : { "a" : { "x" : 1856, "y" : 390 }, "b" : { "x" : 1857, "y" : 382 }, "c" : { "x" : 1850, "y" : 385 }, "type" : "ARROW", "centre" : { "x" : 1850, "y" : 385 } }, "reactionShape" : { "c" : { "x" : 1828, "y" : 421 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 1828, "y" : 421 } }, "inputs" : [ { "id" : 62354, "points" : [ { "x" : 1765, "y" : 377 } ] }, { "id" : 62355, "points" : [ { "x" : 1795, "y" : 456 } ] } ], "outputs" : [ { "id" : 62356 } ] }, { "id" : 62289, "reactomeId" : 10243615, "displayName" : "CD96 binds PVR", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 873, "y" : 185 }, "minX" : 851, "maxX" : 879, "minY" : 155, "maxY" : 191, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 875, "y" : 185 }, "to" : { "x" : 873, "y" : 185 } }, { "from" : { "x" : 873, "y" : 185 }, "to" : { "x" : 851, "y" : 155 } } ], "endShape" : { "a" : { "x" : 858, "y" : 158 }, "b" : { "x" : 851, "y" : 155 }, "c" : { "x" : 852, "y" : 163 }, "type" : "ARROW", "centre" : { "x" : 852, "y" : 163 } }, "reactionShape" : { "c" : { "x" : 873, "y" : 185 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 873, "y" : 185 } }, "inputs" : [ { "id" : 62290, "points" : [ { "x" : 847, "y" : 228 } ] }, { "id" : 62291, "points" : [ { "x" : 903, "y" : 153 } ] } ], "outputs" : [ { "id" : 62292 } ] }, { "id" : 62357, "reactomeId" : 10297370, "displayName" : "TREM,CD300 binds lipids", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 631, "y" : 878 }, "minX" : 594, "maxX" : 659, "minY" : 845, "maxY" : 884, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 594, "y" : 879 }, "to" : { "x" : 631, "y" : 878 } }, { "from" : { "x" : 631, "y" : 878 }, "to" : { "x" : 659, "y" : 845 } } ], "endShape" : { "a" : { "x" : 658, "y" : 853 }, "b" : { "x" : 659, "y" : 845 }, "c" : { "x" : 651, "y" : 848 }, "type" : "ARROW", "centre" : { "x" : 651, "y" : 848 } }, "reactionShape" : { "c" : { "x" : 631, "y" : 878 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 631, "y" : 878 } }, "inputs" : [ { "id" : 62358, "points" : [ { "x" : 567, "y" : 840 } ] }, { "id" : 62359, "points" : [ { "x" : 563, "y" : 907 } ] } ], "outputs" : [ { "id" : 62360 } ] }, { "id" : 62293, "reactomeId" : 10243629, "displayName" : "MADCAM1-1 binds Integrin alpha4beta7", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 1303, "y" : 196 }, "minX" : 1271, "maxX" : 1337, "minY" : 167, "maxY" : 202, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 1337, "y" : 195 }, "to" : { "x" : 1303, "y" : 196 } }, { "from" : { "x" : 1303, "y" : 196 }, "to" : { "x" : 1271, "y" : 167 } } ], "endShape" : { "a" : { "x" : 1279, "y" : 169 }, "b" : { "x" : 1271, "y" : 167 }, "c" : { "x" : 1273, "y" : 175 }, "type" : "ARROW", "centre" : { "x" : 1273, "y" : 175 } }, "reactionShape" : { "c" : { "x" : 1303, "y" : 196 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 1303, "y" : 196 } }, "inputs" : [ { "id" : 62294, "points" : [ { "x" : 1359, "y" : 159 } ] }, { "id" : 62295, "points" : [ { "x" : 1371, "y" : 232 } ], "stoichiometry" : 2 } ], "outputs" : [ { "id" : 62296 } ] }, { "id" : 62297, "reactomeId" : 10243803, "displayName" : "Ligands bind L-selectin", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 237, "y" : 412 }, "minX" : 203, "maxX" : 261, "minY" : 383, "maxY" : 418, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 203, "y" : 414 }, "to" : { "x" : 237, "y" : 412 } }, { "from" : { "x" : 237, "y" : 412 }, "to" : { "x" : 261, "y" : 383 } } ], "endShape" : { "a" : { "x" : 260, "y" : 391 }, "b" : { "x" : 261, "y" : 383 }, "c" : { "x" : 254, "y" : 386 }, "type" : "ARROW", "centre" : { "x" : 254, "y" : 386 } }, "reactionShape" : { "c" : { "x" : 237, "y" : 412 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 237, "y" : 412 } }, "inputs" : [ { "id" : 62298, "points" : [ { "x" : 165, "y" : 376 } ] }, { "id" : 62299, "points" : [ { "x" : 176, "y" : 451 } ] } ], "outputs" : [ { "id" : 62300 } ] }, { "id" : 62361, "reactomeId" : 10306803, "displayName" : "TCR binds microbial lipid-based antigen via CD1", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 1856, "y" : 197 }, "minX" : 1821, "maxX" : 1877, "minY" : 170, "maxY" : 203, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 1877, "y" : 197 }, "to" : { "x" : 1856, "y" : 197 } }, { "from" : { "x" : 1856, "y" : 197 }, "to" : { "x" : 1821, "y" : 170 } } ], "endShape" : { "a" : { "x" : 1829, "y" : 171 }, "b" : { "x" : 1821, "y" : 170 }, "c" : { "x" : 1824, "y" : 177 }, "type" : "ARROW", "centre" : { "x" : 1824, "y" : 177 } }, "reactionShape" : { "c" : { "x" : 1856, "y" : 197 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 1856, "y" : 197 } }, "inputs" : [ { "id" : 62362, "points" : [ { "x" : 1920, "y" : 167 } ] }, { "id" : 62363, "points" : [ { "x" : 1940, "y" : 227 } ] } ], "outputs" : [ { "id" : 62364 } ] }, { "id" : 62301, "reactomeId" : 10243839, "displayName" : "ICAM1-5 bind Integrin alphaLbeta2 (LFA-1)", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 322, "y" : 425 }, "minX" : 300, "maxX" : 387, "minY" : 419, "maxY" : 449, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 387, "y" : 425 }, "to" : { "x" : 322, "y" : 425 } }, { "from" : { "x" : 322, "y" : 425 }, "to" : { "x" : 300, "y" : 449 } } ], "endShape" : { "a" : { "x" : 302, "y" : 441 }, "b" : { "x" : 300, "y" : 449 }, "c" : { "x" : 308, "y" : 447 }, "type" : "ARROW", "centre" : { "x" : 308, "y" : 447 } }, "reactionShape" : { "c" : { "x" : 322, "y" : 425 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 322, "y" : 425 } }, "inputs" : [ { "id" : 62302, "points" : [ { "x" : 405, "y" : 373 } ] }, { "id" : 62303, "points" : [ { "x" : 401, "y" : 450 } ] } ], "outputs" : [ { "id" : 62304 } ] }, { "id" : 62365, "reactomeId" : 10306785, "displayName" : "TCR binds self-lipid-based antigen via CD1", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 1763, "y" : 203 }, "minX" : 1707, "maxX" : 1807, "minY" : 166, "maxY" : 209, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 1807, "y" : 204 }, "to" : { "x" : 1763, "y" : 203 } }, { "from" : { "x" : 1763, "y" : 203 }, "to" : { "x" : 1707, "y" : 166 } } ], "endShape" : { "a" : { "x" : 1715, "y" : 166 }, "b" : { "x" : 1707, "y" : 166 }, "c" : { "x" : 1711, "y" : 173 }, "type" : "ARROW", "centre" : { "x" : 1711, "y" : 173 } }, "reactionShape" : { "c" : { "x" : 1763, "y" : 203 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 1763, "y" : 203 } }, "inputs" : [ { "id" : 62362, "points" : [ { "x" : 1903, "y" : 160 } ] }, { "id" : 62366, "points" : [ { "x" : 1820, "y" : 214 } ] } ], "outputs" : [ { "id" : 62367 } ] }, { "id" : 62368, "reactomeId" : 10308460, "displayName" : "PILRA binds PIANP, COLLEC12 trimer, NPDC1, CLEC4G", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 1020, "y" : 878 }, "minX" : 988, "maxX" : 1058, "minY" : 872, "maxY" : 903, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 988, "y" : 877 }, "to" : { "x" : 1020, "y" : 878 } }, { "from" : { "x" : 1020, "y" : 878 }, "to" : { "x" : 1058, "y" : 903 } } ], "endShape" : { "a" : { "x" : 1050, "y" : 903 }, "b" : { "x" : 1058, "y" : 903 }, "c" : { "x" : 1054, "y" : 896 }, "type" : "ARROW", "centre" : { "x" : 1054, "y" : 896 } }, "reactionShape" : { "c" : { "x" : 1020, "y" : 878 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 1020, "y" : 878 } }, "inputs" : [ { "id" : 62369, "points" : [ { "x" : 942, "y" : 832 } ] }, { "id" : 62370, "points" : [ { "x" : 975, "y" : 900 } ] } ], "outputs" : [ { "id" : 62371 } ] }, { "id" : 62305, "reactomeId" : 10243863, "displayName" : "CRTAM binds to NECL2", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 1208, "y" : 200 }, "minX" : 1182, "maxX" : 1237, "minY" : 194, "maxY" : 221, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 1182, "y" : 200 }, "to" : { "x" : 1208, "y" : 200 } }, { "from" : { "x" : 1208, "y" : 200 }, "to" : { "x" : 1237, "y" : 221 } } ], "endShape" : { "a" : { "x" : 1229, "y" : 220 }, "b" : { "x" : 1237, "y" : 221 }, "c" : { "x" : 1234, "y" : 214 }, "type" : "ARROW", "centre" : { "x" : 1234, "y" : 214 } }, "reactionShape" : { "c" : { "x" : 1208, "y" : 200 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 1208, "y" : 200 } }, "inputs" : [ { "id" : 62306, "points" : [ { "x" : 1120, "y" : 155 } ] }, { "id" : 62307, "points" : [ { "x" : 1159, "y" : 230 } ] } ], "outputs" : [ { "id" : 62308 } ] }, { "id" : 62372, "reactomeId" : 10308442, "displayName" : "PILRA,PILRB bind CD99", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 813, "y" : 878 }, "minX" : 787, "maxX" : 830, "minY" : 872, "maxY" : 910, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 787, "y" : 878 }, "to" : { "x" : 813, "y" : 878 } }, { "from" : { "x" : 813, "y" : 878 }, "to" : { "x" : 830, "y" : 910 } } ], "endShape" : { "a" : { "x" : 823, "y" : 906 }, "b" : { "x" : 830, "y" : 910 }, "c" : { "x" : 830, "y" : 902 }, "type" : "ARROW", "centre" : { "x" : 830, "y" : 902 } }, "reactionShape" : { "c" : { "x" : 813, "y" : 878 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 813, "y" : 878 } }, "inputs" : [ { "id" : 62373, "points" : [ { "x" : 752, "y" : 918 } ] }, { "id" : 62374, "points" : [ { "x" : 780, "y" : 839 } ] } ], "outputs" : [ { "id" : 62375 } ] }, { "id" : 62309, "reactomeId" : 10243871, "displayName" : "PVR binds CD226", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 980, "y" : 189 }, "minX" : 946, "maxX" : 992, "minY" : 157, "maxY" : 195, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 946, "y" : 189 }, "to" : { "x" : 980, "y" : 189 } }, { "from" : { "x" : 980, "y" : 189 }, "to" : { "x" : 992, "y" : 157 } } ], "endShape" : { "a" : { "x" : 993, "y" : 165 }, "b" : { "x" : 992, "y" : 157 }, "c" : { "x" : 986, "y" : 162 }, "type" : "ARROW", "centre" : { "x" : 986, "y" : 162 } }, "reactionShape" : { "c" : { "x" : 980, "y" : 189 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 980, "y" : 189 } }, "inputs" : [ { "id" : 62291, "points" : [ { "x" : 920, "y" : 153 } ] }, { "id" : 62310, "points" : [ { "x" : 921, "y" : 231 } ] } ], "outputs" : [ { "id" : 62311 } ] }, { "id" : 62376, "reactomeId" : 10320173, "displayName" : "ITGA4:ITGB1 binds natalizumab", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 107, "y" : 42 }, "minX" : 101, "maxX" : 146, "minY" : 36, "maxY" : 62, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 108, "y" : 43 }, "to" : { "x" : 107, "y" : 42 } }, { "from" : { "x" : 107, "y" : 42 }, "to" : { "x" : 146, "y" : 62 } } ], "endShape" : { "a" : { "x" : 138, "y" : 62 }, "b" : { "x" : 146, "y" : 62 }, "c" : { "x" : 142, "y" : 55 }, "type" : "ARROW", "centre" : { "x" : 142, "y" : 55 } }, "reactionShape" : { "c" : { "x" : 107, "y" : 42 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 107, "y" : 42 } }, "inputs" : [ { "id" : 62377, "points" : [ { "x" : 73, "y" : 27 } ] }, { "id" : 62277, "points" : [ { "x" : 98, "y" : 127 } ] } ], "outputs" : [ { "id" : 62280 } ] }, { "id" : 62312, "reactomeId" : 10243875, "displayName" : "Nectin 2 binds CD226", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 1039, "y" : 206 }, "minX" : 1010, "maxX" : 1046, "minY" : 200, "maxY" : 228, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 1010, "y" : 208 }, "to" : { "x" : 1039, "y" : 206 } }, { "from" : { "x" : 1039, "y" : 206 }, "to" : { "x" : 1046, "y" : 228 } } ], "endShape" : { "a" : { "x" : 1040, "y" : 223 }, "b" : { "x" : 1046, "y" : 228 }, "c" : { "x" : 1048, "y" : 220 }, "type" : "ARROW", "centre" : { "x" : 1048, "y" : 220 } }, "reactionShape" : { "c" : { "x" : 1039, "y" : 206 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 1039, "y" : 206 } }, "inputs" : [ { "id" : 62306, "points" : [ { "x" : 1090, "y" : 155 } ], "stoichiometry" : 2 }, { "id" : 62310, "points" : [ { "x" : 946, "y" : 234 } ] } ], "outputs" : [ { "id" : 62313 } ] }, { "id" : 62314, "reactomeId" : 10243887, "displayName" : "CD200 binds to CD200R", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 841, "y" : 405 }, "minX" : 824, "maxX" : 891, "minY" : 372, "maxY" : 411, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 891, "y" : 407 }, "to" : { "x" : 841, "y" : 405 } }, { "from" : { "x" : 841, "y" : 405 }, "to" : { "x" : 824, "y" : 372 } } ], "endShape" : { "a" : { "x" : 831, "y" : 376 }, "b" : { "x" : 824, "y" : 372 }, "c" : { "x" : 824, "y" : 380 }, "type" : "ARROW", "centre" : { "x" : 824, "y" : 380 } }, "reactionShape" : { "c" : { "x" : 841, "y" : 405 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 841, "y" : 405 } }, "inputs" : [ { "id" : 62315, "points" : [ { "x" : 917, "y" : 446 } ] }, { "id" : 62316, "points" : [ { "x" : 914, "y" : 367 } ] } ], "outputs" : [ { "id" : 62317 } ] }, { "id" : 62318, "reactomeId" : 10243897, "displayName" : "MHC Class I interacts with CD160", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 1119, "y" : 406 }, "minX" : 1079, "maxX" : 1148, "minY" : 400, "maxY" : 428, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 1079, "y" : 405 }, "to" : { "x" : 1119, "y" : 406 } }, { "from" : { "x" : 1119, "y" : 406 }, "to" : { "x" : 1148, "y" : 428 } } ], "endShape" : { "a" : { "x" : 1140, "y" : 427 }, "b" : { "x" : 1148, "y" : 428 }, "c" : { "x" : 1145, "y" : 421 }, "type" : "ARROW", "centre" : { "x" : 1145, "y" : 421 } }, "reactionShape" : { "c" : { "x" : 1119, "y" : 406 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 1119, "y" : 406 } }, "inputs" : [ { "id" : 62319, "points" : [ { "x" : 1047, "y" : 371 } ] }, { "id" : 62320, "points" : [ { "x" : 1059, "y" : 421 } ] } ], "outputs" : [ { "id" : 62321 } ] }, { "id" : 62322, "reactomeId" : 10244003, "displayName" : "CD40L binds CD40", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 1461, "y" : 423 }, "minX" : 1433, "maxX" : 1500, "minY" : 417, "maxY" : 437, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 1433, "y" : 422 }, "to" : { "x" : 1461, "y" : 423 } }, { "from" : { "x" : 1461, "y" : 423 }, "to" : { "x" : 1500, "y" : 437 } } ], "endShape" : { "a" : { "x" : 1492, "y" : 438 }, "b" : { "x" : 1500, "y" : 437 }, "c" : { "x" : 1495, "y" : 431 }, "type" : "ARROW", "centre" : { "x" : 1495, "y" : 431 } }, "reactionShape" : { "c" : { "x" : 1461, "y" : 423 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 1461, "y" : 423 } }, "inputs" : [ { "id" : 62323, "points" : [ { "x" : 1425, "y" : 373 } ] }, { "id" : 62324, "points" : [ { "x" : 1423, "y" : 449 } ] } ], "outputs" : [ { "id" : 62325 } ] }, { "id" : 62326, "reactomeId" : 10243851, "displayName" : "CXADR binds to AMICA1", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 1594, "y" : 411 }, "minX" : 1561, "maxX" : 1637, "minY" : 374, "maxY" : 417, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 1637, "y" : 412 }, "to" : { "x" : 1594, "y" : 411 } }, { "from" : { "x" : 1594, "y" : 411 }, "to" : { "x" : 1561, "y" : 374 } } ], "endShape" : { "a" : { "x" : 1569, "y" : 377 }, "b" : { "x" : 1561, "y" : 374 }, "c" : { "x" : 1563, "y" : 382 }, "type" : "ARROW", "centre" : { "x" : 1563, "y" : 382 } }, "reactionShape" : { "c" : { "x" : 1594, "y" : 411 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 1594, "y" : 411 } }, "inputs" : [ { "id" : 62327, "points" : [ { "x" : 1702, "y" : 460 } ] }, { "id" : 62328, "points" : [ { "x" : 1653, "y" : 369 } ] } ], "outputs" : [ { "id" : 62329 } ] }, { "id" : 62330, "reactomeId" : 10244090, "displayName" : "C3d-complexed antigen binds to complement receptor", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 188, "y" : 656 }, "minX" : 171, "maxX" : 205, "minY" : 650, "maxY" : 666, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 171, "y" : 654 }, "to" : { "x" : 188, "y" : 656 } }, { "from" : { "x" : 188, "y" : 656 }, "to" : { "x" : 205, "y" : 666 } } ], "endShape" : { "a" : { "x" : 197, "y" : 666 }, "b" : { "x" : 205, "y" : 666 }, "c" : { "x" : 201, "y" : 659 }, "type" : "ARROW", "centre" : { "x" : 201, "y" : 659 } }, "reactionShape" : { "c" : { "x" : 188, "y" : 656 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 188, "y" : 656 } }, "inputs" : [ { "id" : 62331, "points" : [ { "x" : 152, "y" : 625 } ] }, { "id" : 62332, "points" : [ { "x" : 152, "y" : 680 } ] } ], "outputs" : [ { "id" : 62333 } ] }, { "id" : 62334, "reactomeId" : 10294376, "displayName" : "CLEC2D binds KLRB1", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 1197, "y" : 644 }, "minX" : 1174, "maxX" : 1218, "minY" : 625, "maxY" : 650, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 1174, "y" : 646 }, "to" : { "x" : 1197, "y" : 644 } }, { "from" : { "x" : 1197, "y" : 644 }, "to" : { "x" : 1218, "y" : 625 } } ], "endShape" : { "a" : { "x" : 1216, "y" : 633 }, "b" : { "x" : 1218, "y" : 625 }, "c" : { "x" : 1210, "y" : 627 }, "type" : "ARROW", "centre" : { "x" : 1210, "y" : 627 } }, "reactionShape" : { "c" : { "x" : 1197, "y" : 644 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 1197, "y" : 644 } }, "inputs" : [ { "id" : 62335, "points" : [ { "x" : 1153, "y" : 603 } ] }, { "id" : 62336, "points" : [ { "x" : 1165, "y" : 692 } ] } ], "outputs" : [ { "id" : 62337 } ] } ], "compartments" : [ { "id" : 62384, "reactomeId" : 259388, "displayName" : "virion membrane", "schemaClass" : "Compartment", "renderableClass" : "Compartment", "position" : { "x" : 1919, "y" : 933 }, "minX" : 1834, "maxX" : 2005, "minY" : 894, "maxY" : 972, "prop" : { "x" : 1834, "y" : 894, "width" : 171, "height" : 78 }, "textPosition" : { "x" : 1856, "y" : 933 }, "bgColor" : { "r" : 250, "g" : 240, "b" : 240 } }, { "id" : 62389, "reactomeId" : 70101, "displayName" : "cytosol", "schemaClass" : "Compartment", "renderableClass" : "Compartment", "position" : { "x" : 1143, "y" : 113 }, "minX" : 95, "maxX" : 2191, "minY" : 77, "maxY" : 149, "prop" : { "x" : 95, "y" : 77, "width" : 2096, "height" : 72 }, "textPosition" : { "x" : 848, "y" : 84 }, "insets" : { "x" : 105, "y" : 87, "width" : 2076, "height" : 52 }, "bgColor" : { "r" : 250, "g" : 240, "b" : 240 }, "componentIds" : [ 62277, 62282, 62284, 62292, 62294, 62296, 62311, 62382, 62291, 62306, 62362, 62364, 62367, 62280 ] }, { "id" : 62390, "reactomeId" : 70101, "displayName" : "cytosol", "schemaClass" : "Compartment", "renderableClass" : "Compartment", "position" : { "x" : 1127, "y" : 296 }, "minX" : 95, "maxX" : 2159, "minY" : 236, "maxY" : 356, "prop" : { "x" : 95, "y" : 236, "width" : 2064, "height" : 120 }, "textPosition" : { "x" : 760, "y" : 266 }, "insets" : { "x" : 105, "y" : 246, "width" : 2044, "height" : 100 }, "bgColor" : { "r" : 250, "g" : 240, "b" : 240 }, "componentIds" : [ 62278, 62279, 62283, 62290, 62295, 62298, 62300, 62307, 62308, 62310, 62313, 62317, 62394, 62395, 62302, 62316, 62319, 62328, 62329, 62323, 62354, 62363, 62366, 62356, 62351 ] }, { "id" : 62391, "reactomeId" : 70101, "displayName" : "cytosol", "schemaClass" : "Compartment", "renderableClass" : "Compartment", "position" : { "x" : 1129, "y" : 528 }, "minX" : 101, "maxX" : 2157, "minY" : 464, "maxY" : 592, "prop" : { "x" : 101, "y" : 464, "width" : 2056, "height" : 128 }, "textPosition" : { "x" : 1099, "y" : 511 }, "insets" : { "x" : 111, "y" : 474, "width" : 2036, "height" : 108 }, "bgColor" : { "r" : 250, "g" : 240, "b" : 240 }, "componentIds" : [ 62299, 62303, 62304, 62315, 62320, 62321, 62331, 62337, 62286, 62288, 62325, 62327, 62324, 62335, 62341, 62348, 62343, 62355, 62339, 62349, 62352 ] }, { "id" : 62392, "reactomeId" : 70101, "displayName" : "cytosol", "schemaClass" : "Compartment", "renderableClass" : "Compartment", "position" : { "x" : 1127, "y" : 763 }, "minX" : 99, "maxX" : 2155, "minY" : 701, "maxY" : 825, "prop" : { "x" : 99, "y" : 701, "width" : 2056, "height" : 124 }, "textPosition" : { "x" : 1097, "y" : 746 }, "insets" : { "x" : 109, "y" : 711, "width" : 2036, "height" : 104 }, "bgColor" : { "r" : 250, "g" : 240, "b" : 240 }, "componentIds" : [ 62287, 62332, 62333, 62336, 62340, 62344, 62347, 62358, 62360, 62345, 62374, 62369, 62397 ] }, { "id" : 62393, "reactomeId" : 70101, "displayName" : "cytosol", "schemaClass" : "Compartment", "renderableClass" : "Compartment", "position" : { "x" : 1109, "y" : 964 }, "minX" : 439, "maxX" : 1780, "minY" : 924, "maxY" : 1005, "prop" : { "x" : 439, "y" : 924, "width" : 1341, "height" : 81 }, "textPosition" : { "x" : 462, "y" : 959 }, "insets" : { "x" : 449, "y" : 934, "width" : 1321, "height" : 61 }, "bgColor" : { "r" : 250, "g" : 240, "b" : 240 }, "componentIds" : [ 62373, 62375, 62359, 62371, 62370 ] } ], "notes" : [ ], "links" : [ { "id" : 62394, "renderableClass" : "EntitySetAndMemberLink", "position" : { "x" : 769, "y" : 304 }, "minX" : 192, "maxX" : 1361, "minY" : 260, "maxY" : 328, "segments" : [ { "from" : { "x" : 1361, "y" : 260 }, "to" : { "x" : 1281, "y" : 301 } }, { "from" : { "x" : 1281, "y" : 301 }, "to" : { "x" : 257, "y" : 307 } }, { "from" : { "x" : 257, "y" : 307 }, "to" : { "x" : 192, "y" : 328 } } ], "reactionShape" : { "a" : { "x" : 763, "y" : 298 }, "b" : { "x" : 775, "y" : 310 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 769, "y" : 304 } }, "inputs" : [ { "id" : 62295 } ], "outputs" : [ { "id" : 62298 } ] }, { "id" : 62395, "renderableClass" : "EntitySetAndMemberLink", "position" : { "x" : 793, "y" : 319 }, "minX" : 628, "maxX" : 1013, "minY" : 158, "maxY" : 421, "segments" : [ { "from" : { "x" : 636, "y" : 158 }, "to" : { "x" : 628, "y" : 319 } }, { "from" : { "x" : 628, "y" : 319 }, "to" : { "x" : 958, "y" : 319 } }, { "from" : { "x" : 958, "y" : 319 }, "to" : { "x" : 1013, "y" : 421 } } ], "reactionShape" : { "a" : { "x" : 787, "y" : 313 }, "b" : { "x" : 799, "y" : 325 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 793, "y" : 319 } }, "inputs" : [ { "id" : 62382 } ], "outputs" : [ { "id" : 62320 } ] }, { "id" : 62396, "renderableClass" : "EntitySetAndEntitySetLink", "position" : { "x" : 221, "y" : 916 }, "minX" : 215, "maxX" : 227, "minY" : 910, "maxY" : 922, "segments" : [ { "from" : { "x" : 226, "y" : 916 }, "to" : { "x" : 216, "y" : 916 } } ], "reactionShape" : { "a" : { "x" : 215, "y" : 910 }, "b" : { "x" : 227, "y" : 922 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 221, "y" : 916 } }, "inputs" : [ { "id" : 62387 } ], "outputs" : [ { "id" : 62385 } ] }, { "id" : 62397, "renderableClass" : "EntitySetAndMemberLink", "position" : { "x" : 865, "y" : 818 }, "minX" : 822, "maxX" : 908, "minY" : 812, "maxY" : 824, "segments" : [ { "from" : { "x" : 908, "y" : 818 }, "to" : { "x" : 822, "y" : 818 } } ], "reactionShape" : { "a" : { "x" : 859, "y" : 812 }, "b" : { "x" : 871, "y" : 824 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 865, "y" : 818 } }, "inputs" : [ { "id" : 62369 } ], "outputs" : [ { "id" : 62374 } ] } ], "shadows" : [ ], "minX" : 0, "maxX" : 2191, "minY" : 0, "maxY" : 1005, "disease" : false }