{ "dbId" : 10329643, "stableId" : "R-CFA-917937", "displayName" : "Iron uptake and transport", "nodes" : [ { "id" : 31232, "reactomeId" : 70106, "displayName" : "H+", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 913, "y" : 854 }, "minX" : 858, "maxX" : 932, "minY" : 829, "maxY" : 869, "prop" : { "x" : 895, "y" : 839, "width" : 36, "height" : 30 }, "textPosition" : { "x" : 899, "y" : 843 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 926, "y" : 844 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 926, "y" : 844 } } }, "connectors" : [ { "edgeId" : 31229, "type" : "INPUT", "segments" : [ { "from" : { "x" : 892, "y" : 845 }, "to" : { "x" : 858, "y" : 829 } } ], "stoichiometry" : { "value" : 3, "shape" : { "a" : { "x" : 869, "y" : 831 }, "b" : { "x" : 881, "y" : 843 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 875, "y" : 837 } } } } ], "trivial" : true }, { "id" : 31233, "reactomeId" : 74722, "displayName" : "H+", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 731, "y" : 691 }, "minX" : 713, "maxX" : 750, "minY" : 675, "maxY" : 829, "prop" : { "x" : 713, "y" : 676, "width" : 36, "height" : 30 }, "textPosition" : { "x" : 717, "y" : 680 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 744, "y" : 681 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 744, "y" : 681 } } }, "connectors" : [ { "edgeId" : 31229, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 731, "y" : 709 }, "to" : { "x" : 736, "y" : 829 } } ], "stoichiometry" : { "value" : 3, "shape" : { "a" : { "x" : 727, "y" : 763 }, "b" : { "x" : 739, "y" : 775 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 733, "y" : 769 } } }, "endShape" : { "a" : { "x" : 735, "y" : 716 }, "b" : { "x" : 731, "y" : 709 }, "c" : { "x" : 727, "y" : 716 }, "type" : "ARROW", "centre" : { "x" : 727, "y" : 716 } } } ], "trivial" : true }, { "id" : 31234, "reactomeId" : 29370, "displayName" : "ADP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 670, "y" : 804 }, "minX" : 650, "maxX" : 736, "minY" : 788, "maxY" : 829, "prop" : { "x" : 650, "y" : 789, "width" : 41, "height" : 30 }, "textPosition" : { "x" : 654, "y" : 793 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 686, "y" : 794 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 686, "y" : 794 } } }, "connectors" : [ { "edgeId" : 31229, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 694, "y" : 811 }, "to" : { "x" : 736, "y" : 829 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 702, "y" : 810 }, "b" : { "x" : 694, "y" : 811 }, "c" : { "x" : 699, "y" : 817 }, "type" : "ARROW", "centre" : { "x" : 699, "y" : 817 } } } ] }, { "id" : 31235, "reactomeId" : 29372, "displayName" : "Pi", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 679, "y" : 849 }, "minX" : 666, "maxX" : 736, "minY" : 829, "maxY" : 864, "prop" : { "x" : 666, "y" : 834, "width" : 27, "height" : 30 }, "textPosition" : { "x" : 670, "y" : 838 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 688, "y" : 839 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 688, "y" : 839 } } }, "connectors" : [ { "edgeId" : 31229, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 696, "y" : 844 }, "to" : { "x" : 736, "y" : 829 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 701, "y" : 838 }, "b" : { "x" : 696, "y" : 844 }, "c" : { "x" : 704, "y" : 845 }, "type" : "ARROW", "centre" : { "x" : 704, "y" : 845 } } } ] }, { "id" : 31237, "reactomeId" : 111736, "displayName" : "Fe3+", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1269, "y" : 381 }, "minX" : 1182, "maxX" : 1294, "minY" : 344, "maxY" : 442, "prop" : { "x" : 1245, "y" : 366, "width" : 48, "height" : 30 }, "textPosition" : { "x" : 1248, "y" : 370 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1288, "y" : 371 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1288, "y" : 371 } } }, "connectors" : [ { "edgeId" : 31236, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1247, "y" : 399 }, "to" : { "x" : 1182, "y" : 442 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 31253, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 1242, "y" : 366 }, "to" : { "x" : 1206, "y" : 344 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1234, "y" : 366 }, "b" : { "x" : 1242, "y" : 366 }, "c" : { "x" : 1238, "y" : 359 }, "type" : "ARROW", "centre" : { "x" : 1238, "y" : 359 } } } ] }, { "id" : 31238, "reactomeId" : 29364, "displayName" : "NADPH", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1133, "y" : 408 }, "minX" : 1104, "maxX" : 1182, "minY" : 392, "maxY" : 442, "prop" : { "x" : 1104, "y" : 393, "width" : 59, "height" : 30 }, "textPosition" : { "x" : 1108, "y" : 397 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1158, "y" : 398 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1158, "y" : 398 } } }, "connectors" : [ { "edgeId" : 31236, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1154, "y" : 426 }, "to" : { "x" : 1182, "y" : 442 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 31239, "reactomeId" : 9861421, "displayName" : "NADP+", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1167, "y" : 601 }, "minX" : 1140, "maxX" : 1196, "minY" : 536, "maxY" : 617, "prop" : { "x" : 1140, "y" : 586, "width" : 55, "height" : 31 }, "textPosition" : { "x" : 1141, "y" : 591 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1190, "y" : 591 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1190, "y" : 591 } } }, "connectors" : [ { "edgeId" : 31236, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 1171, "y" : 583 }, "to" : { "x" : 1184, "y" : 536 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1169, "y" : 575 }, "b" : { "x" : 1171, "y" : 583 }, "c" : { "x" : 1177, "y" : 577 }, "type" : "ARROW", "centre" : { "x" : 1177, "y" : 577 } } } ] }, { "id" : 31240, "reactomeId" : 917810, "displayName" : "Fe2+", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1078, "y" : 583 }, "minX" : 1054, "maxX" : 1184, "minY" : 536, "maxY" : 598, "prop" : { "x" : 1054, "y" : 568, "width" : 48, "height" : 30 }, "textPosition" : { "x" : 1057, "y" : 572 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1097, "y" : 573 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1097, "y" : 573 } } }, "connectors" : [ { "edgeId" : 31236, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 1105, "y" : 572 }, "to" : { "x" : 1184, "y" : 536 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1110, "y" : 565 }, "b" : { "x" : 1105, "y" : 572 }, "c" : { "x" : 1113, "y" : 573 }, "type" : "ARROW", "centre" : { "x" : 1113, "y" : 573 } } }, { "edgeId" : 31243, "type" : "INPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 31241, "reactomeId" : 74722, "displayName" : "H+", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1229, "y" : 574 }, "minX" : 1184, "maxX" : 1248, "minY" : 536, "maxY" : 589, "prop" : { "x" : 1211, "y" : 559, "width" : 36, "height" : 30 }, "textPosition" : { "x" : 1215, "y" : 563 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1242, "y" : 564 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1242, "y" : 564 } } }, "connectors" : [ { "edgeId" : 31236, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 1211, "y" : 556 }, "to" : { "x" : 1184, "y" : 536 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1203, "y" : 555 }, "b" : { "x" : 1211, "y" : 556 }, "c" : { "x" : 1208, "y" : 549 }, "type" : "ARROW", "centre" : { "x" : 1208, "y" : 549 } } } ], "trivial" : true }, { "id" : 31242, "reactomeId" : 10262132, "displayName" : "STEAP3,STEAP4", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 1076, "y" : 490 }, "minX" : 1045, "maxX" : 1175, "minY" : 469, "maxY" : 511, "prop" : { "x" : 1045, "y" : 469, "width" : 63, "height" : 42 }, "textPosition" : { "x" : 1047, "y" : 472 }, "connectors" : [ { "edgeId" : 31236, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 1114, "y" : 490 }, "to" : { "x" : 1167, "y" : 491 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 1171, "y" : 491 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1171, "y" : 491 } } } ] }, { "id" : 31244, "reactomeId" : 10262157, "displayName" : "MCOLN1", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 614, "y" : 635 }, "minX" : 585, "maxX" : 650, "minY" : 593, "maxY" : 646, "prop" : { "x" : 585, "y" : 624, "width" : 59, "height" : 22 }, "textPosition" : { "x" : 585, "y" : 624 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 644, "y" : 624 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 644, "y" : 624 } } }, "connectors" : [ { "edgeId" : 31243, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 614, "y" : 621 }, "to" : { "x" : 614, "y" : 601 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 614, "y" : 597 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 614, "y" : 597 } } } ] }, { "id" : 31246, "reactomeId" : 70106, "displayName" : "H+", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 477, "y" : 389 }, "minX" : 459, "maxX" : 502, "minY" : 373, "maxY" : 438, "prop" : { "x" : 459, "y" : 374, "width" : 36, "height" : 30 }, "textPosition" : { "x" : 463, "y" : 378 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 490, "y" : 379 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 490, "y" : 379 } } }, "connectors" : [ { "edgeId" : 31245, "type" : "INPUT", "segments" : [ { "from" : { "x" : 484, "y" : 407 }, "to" : { "x" : 502, "y" : 438 } } ], "stoichiometry" : { "value" : 4, "shape" : { "a" : { "x" : 487, "y" : 416 }, "b" : { "x" : 499, "y" : 428 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 493, "y" : 422 } } } } ], "trivial" : true }, { "id" : 31247, "reactomeId" : 29368, "displayName" : "O2", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 479, "y" : 476 }, "minX" : 462, "maxX" : 502, "minY" : 438, "maxY" : 491, "prop" : { "x" : 462, "y" : 461, "width" : 34, "height" : 30 }, "textPosition" : { "x" : 466, "y" : 465 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 491, "y" : 466 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 491, "y" : 466 } } }, "connectors" : [ { "edgeId" : 31245, "type" : "INPUT", "segments" : [ { "from" : { "x" : 488, "y" : 458 }, "to" : { "x" : 502, "y" : 438 } } ], "stoichiometry" : { "value" : 4, "shape" : { "a" : { "x" : 489, "y" : 442 }, "b" : { "x" : 501, "y" : 454 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 495, "y" : 448 } } } } ], "trivial" : true }, { "id" : 31248, "reactomeId" : 5691103, "displayName" : "Fe(3+)O(OH)", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 703, "y" : 439 }, "minX" : 605, "maxX" : 750, "minY" : 423, "maxY" : 454, "prop" : { "x" : 658, "y" : 424, "width" : 91, "height" : 30 }, "textPosition" : { "x" : 659, "y" : 428 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 744, "y" : 429 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 744, "y" : 429 } } }, "connectors" : [ { "edgeId" : 31245, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 4, "shape" : { "a" : { "x" : 605, "y" : 432 }, "b" : { "x" : 617, "y" : 444 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 611, "y" : 438 } } } } ] }, { "id" : 31249, "reactomeId" : 10256922, "displayName" : "Ferritin Complex", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 569, "y" : 383 }, "minX" : 517, "maxX" : 627, "minY" : 366, "maxY" : 430, "prop" : { "x" : 517, "y" : 372, "width" : 104, "height" : 22 }, "textPosition" : { "x" : 539, "y" : 359 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 621, "y" : 372 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 621, "y" : 372 } } }, "connectors" : [ { "edgeId" : 31245, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 568, "y" : 397 }, "to" : { "x" : 568, "y" : 422 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 568, "y" : 426 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 568, "y" : 426 } } } ] }, { "id" : 31251, "reactomeId" : 10286900, "displayName" : "LCN2:2,5DHBA", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 952, "y" : 221 }, "minX" : 904, "maxX" : 1007, "minY" : 185, "maxY" : 232, "prop" : { "x" : 904, "y" : 210, "width" : 97, "height" : 22 }, "textPosition" : { "x" : 904, "y" : 211 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1001, "y" : 210 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1001, "y" : 210 } } }, "connectors" : [ { "edgeId" : 31250, "type" : "INPUT", "segments" : [ { "from" : { "x" : 958, "y" : 207 }, "to" : { "x" : 973, "y" : 185 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 31252, "reactomeId" : 10286902, "displayName" : "LCN2:2,5DHBA:Fe3+", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 1063, "y" : 184 }, "minX" : 1013, "maxX" : 1120, "minY" : 160, "maxY" : 202, "prop" : { "x" : 1013, "y" : 166, "width" : 101, "height" : 36 }, "textPosition" : { "x" : 1013, "y" : 167 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1114, "y" : 166 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1114, "y" : 166 } } }, "connectors" : [ { "edgeId" : 31250, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 31254, "reactomeId" : 10292683, "displayName" : "SLC22A17:LCN2:2,5DHBA:Fe3+", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 1129, "y" : 283 }, "minX" : 1069, "maxX" : 1196, "minY" : 259, "maxY" : 302, "prop" : { "x" : 1069, "y" : 265, "width" : 121, "height" : 37 }, "textPosition" : { "x" : 1075, "y" : 267 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1190, "y" : 265 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1190, "y" : 265 } } }, "connectors" : [ { "edgeId" : 31253, "type" : "INPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 31255, "reactomeId" : 10292685, "displayName" : "SLC22A17:LCN2:2,5DHBA", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 1280, "y" : 281 }, "minX" : 1206, "maxX" : 1349, "minY" : 257, "maxY" : 344, "prop" : { "x" : 1218, "y" : 263, "width" : 125, "height" : 36 }, "textPosition" : { "x" : 1226, "y" : 264 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1343, "y" : 263 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1343, "y" : 263 } } }, "connectors" : [ { "edgeId" : 31253, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 1258, "y" : 302 }, "to" : { "x" : 1206, "y" : 344 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1255, "y" : 309 }, "b" : { "x" : 1258, "y" : 302 }, "c" : { "x" : 1250, "y" : 303 }, "type" : "ARROW", "centre" : { "x" : 1250, "y" : 303 } } } ] }, { "id" : 31256, "reactomeId" : 10292681, "displayName" : "SLC22A17", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 1013, "y" : 279 }, "minX" : 979, "maxX" : 1124, "minY" : 262, "maxY" : 348, "prop" : { "x" : 979, "y" : 268, "width" : 69, "height" : 22 }, "textPosition" : { "x" : 982, "y" : 262 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1048, "y" : 268 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1048, "y" : 268 } } }, "connectors" : [ { "edgeId" : 31253, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 1022, "y" : 293 }, "to" : { "x" : 1069, "y" : 344 } }, { "from" : { "x" : 1069, "y" : 344 }, "to" : { "x" : 1116, "y" : 344 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 1120, "y" : 344 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1120, "y" : 344 } } } ] }, { "id" : 31258, "reactomeId" : 113531, "displayName" : "Fe2+", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1414, "y" : 981 }, "minX" : 1390, "maxX" : 1497, "minY" : 965, "maxY" : 1039, "prop" : { "x" : 1390, "y" : 966, "width" : 48, "height" : 30 }, "textPosition" : { "x" : 1393, "y" : 970 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1433, "y" : 971 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1433, "y" : 971 } } }, "connectors" : [ { "edgeId" : 31257, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1435, "y" : 999 }, "to" : { "x" : 1497, "y" : 1039 } } ], "stoichiometry" : { "value" : 4, "shape" : { "a" : { "x" : 1460, "y" : 1013 }, "b" : { "x" : 1472, "y" : 1025 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1466, "y" : 1019 } } } } ] }, { "id" : 31259, "reactomeId" : 113533, "displayName" : "O2", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1410, "y" : 1027 }, "minX" : 1393, "maxX" : 1497, "minY" : 1011, "maxY" : 1042, "prop" : { "x" : 1393, "y" : 1012, "width" : 34, "height" : 30 }, "textPosition" : { "x" : 1397, "y" : 1016 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1422, "y" : 1017 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1422, "y" : 1017 } } }, "connectors" : [ { "edgeId" : 31257, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1430, "y" : 1029 }, "to" : { "x" : 1497, "y" : 1039 } } ], "stoichiometry" : { "value" : 4, "shape" : { "a" : { "x" : 1457, "y" : 1028 }, "b" : { "x" : 1469, "y" : 1040 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1463, "y" : 1034 } } } } ], "trivial" : true }, { "id" : 31260, "reactomeId" : 113529, "displayName" : "H+", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1410, "y" : 1067 }, "minX" : 1392, "maxX" : 1497, "minY" : 1039, "maxY" : 1082, "prop" : { "x" : 1392, "y" : 1052, "width" : 36, "height" : 30 }, "textPosition" : { "x" : 1396, "y" : 1056 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1423, "y" : 1057 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1423, "y" : 1057 } } }, "connectors" : [ { "edgeId" : 31257, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1431, "y" : 1061 }, "to" : { "x" : 1497, "y" : 1039 } } ], "stoichiometry" : { "value" : 4, "shape" : { "a" : { "x" : 1458, "y" : 1044 }, "b" : { "x" : 1470, "y" : 1056 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1464, "y" : 1050 } } } } ], "trivial" : true }, { "id" : 31261, "reactomeId" : 5691135, "displayName" : "Fe(3+)O(OH)", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1671, "y" : 1040 }, "minX" : 1575, "maxX" : 1718, "minY" : 1024, "maxY" : 1055, "prop" : { "x" : 1626, "y" : 1025, "width" : 91, "height" : 30 }, "textPosition" : { "x" : 1627, "y" : 1029 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1712, "y" : 1030 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1712, "y" : 1030 } } }, "connectors" : [ { "edgeId" : 31257, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 4, "shape" : { "a" : { "x" : 1575, "y" : 1033 }, "b" : { "x" : 1587, "y" : 1045 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1581, "y" : 1039 } } } } ] }, { "id" : 31262, "reactomeId" : 10296222, "displayName" : "FTMT 24mer", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 1539, "y" : 988 }, "minX" : 1497, "maxX" : 1587, "minY" : 971, "maxY" : 1031, "prop" : { "x" : 1497, "y" : 977, "width" : 84, "height" : 22 }, "textPosition" : { "x" : 1497, "y" : 978 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1581, "y" : 977 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1581, "y" : 977 } } }, "connectors" : [ { "edgeId" : 31257, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 1539, "y" : 1002 }, "to" : { "x" : 1539, "y" : 1023 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 1539, "y" : 1027 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1539, "y" : 1027 } } } ] }, { "id" : 31264, "reactomeId" : 10296113, "displayName" : "ACO1", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 980, "y" : 1004 }, "minX" : 959, "maxX" : 1023, "minY" : 967, "maxY" : 1015, "prop" : { "x" : 959, "y" : 993, "width" : 42, "height" : 22 }, "textPosition" : { "x" : 959, "y" : 993 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1001, "y" : 993 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1001, "y" : 993 } } }, "connectors" : [ { "edgeId" : 31263, "type" : "INPUT", "segments" : [ { "from" : { "x" : 994, "y" : 990 }, "to" : { "x" : 1023, "y" : 971 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 31263, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 979, "y" : 990 }, "to" : { "x" : 979, "y" : 971 } }, { "from" : { "x" : 979, "y" : 971 }, "to" : { "x" : 1008, "y" : 971 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 1012, "y" : 971 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1012, "y" : 971 } } } ] }, { "id" : 31265, "reactomeId" : 5690881, "displayName" : "4Fe-4S", "schemaClass" : "OtherEntity", "renderableClass" : "Entity", "position" : { "x" : 985, "y" : 927 }, "minX" : 960, "maxX" : 1023, "minY" : 916, "maxY" : 971, "prop" : { "x" : 960, "y" : 916, "width" : 51, "height" : 22 }, "textPosition" : { "x" : 960, "y" : 916 }, "connectors" : [ { "edgeId" : 31263, "type" : "INPUT", "segments" : [ { "from" : { "x" : 994, "y" : 941 }, "to" : { "x" : 1023, "y" : 971 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 31266, "reactomeId" : 10296115, "displayName" : "ACO1:4Fe-4S", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 1114, "y" : 972 }, "minX" : 1070, "maxX" : 1164, "minY" : 955, "maxY" : 983, "prop" : { "x" : 1070, "y" : 961, "width" : 88, "height" : 22 }, "textPosition" : { "x" : 1070, "y" : 962 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1158, "y" : 961 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1158, "y" : 961 } } }, "connectors" : [ { "edgeId" : 31263, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 31267, "reactomeId" : 71067, "displayName" : "Fe2+", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1176, "y" : 1056 }, "minX" : 1032, "maxX" : 1201, "minY" : 975, "maxY" : 1071, "prop" : { "x" : 1152, "y" : 1041, "width" : 48, "height" : 30 }, "textPosition" : { "x" : 1155, "y" : 1045 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1195, "y" : 1046 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1195, "y" : 1046 } } }, "connectors" : [ { "edgeId" : 31263, "type" : "ACTIVATOR", "segments" : [ { "from" : { "x" : 1149, "y" : 1042 }, "to" : { "x" : 1032, "y" : 975 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1040, "y" : 975 }, "b" : { "x" : 1032, "y" : 975 }, "c" : { "x" : 1036, "y" : 982 }, "type" : "ARROW", "empty" : true, "centre" : { "x" : 1036, "y" : 982 } } } ] }, { "id" : 31269, "reactomeId" : 10239768, "displayName" : "CUL1", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 411, "y" : 1068 }, "minX" : 358, "maxX" : 518, "minY" : 1033, "maxY" : 1079, "prop" : { "x" : 392, "y" : 1057, "width" : 39, "height" : 22 }, "textPosition" : { "x" : 392, "y" : 1057 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 431, "y" : 1057 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 431, "y" : 1057 } } }, "connectors" : [ { "edgeId" : 31268, "type" : "INPUT", "segments" : [ { "from" : { "x" : 394, "y" : 1054 }, "to" : { "x" : 358, "y" : 1033 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 31272, "type" : "INPUT", "segments" : [ { "from" : { "x" : 434, "y" : 1068 }, "to" : { "x" : 518, "y" : 1068 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 31270, "reactomeId" : 10296239, "displayName" : "CAND1", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 406, "y" : 996 }, "minX" : 358, "maxX" : 438, "minY" : 979, "maxY" : 1033, "prop" : { "x" : 381, "y" : 985, "width" : 51, "height" : 22 }, "textPosition" : { "x" : 381, "y" : 985 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 432, "y" : 985 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 432, "y" : 985 } } }, "connectors" : [ { "edgeId" : 31268, "type" : "INPUT", "segments" : [ { "from" : { "x" : 391, "y" : 1010 }, "to" : { "x" : 358, "y" : 1033 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 31271, "reactomeId" : 10296241, "displayName" : "CANDI:CUL1", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 271, "y" : 1035 }, "minX" : 231, "maxX" : 317, "minY" : 1018, "maxY" : 1046, "prop" : { "x" : 231, "y" : 1024, "width" : 80, "height" : 22 }, "textPosition" : { "x" : 231, "y" : 1025 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 311, "y" : 1024 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 311, "y" : 1024 } } }, "connectors" : [ { "edgeId" : 31268, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 31273, "reactomeId" : 10263652, "displayName" : "FBXL5", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 475, "y" : 1102 }, "minX" : 453, "maxX" : 518, "minY" : 1068, "maxY" : 1113, "prop" : { "x" : 453, "y" : 1091, "width" : 44, "height" : 22 }, "textPosition" : { "x" : 453, "y" : 1091 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 497, "y" : 1091 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 497, "y" : 1091 } } }, "connectors" : [ { "edgeId" : 31272, "type" : "INPUT", "segments" : [ { "from" : { "x" : 488, "y" : 1088 }, "to" : { "x" : 518, "y" : 1068 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 31274, "reactomeId" : 10239766, "displayName" : "SKP1", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 473, "y" : 1035 }, "minX" : 454, "maxX" : 518, "minY" : 1018, "maxY" : 1068, "prop" : { "x" : 454, "y" : 1024, "width" : 38, "height" : 22 }, "textPosition" : { "x" : 457, "y" : 1018 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 492, "y" : 1024 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 492, "y" : 1024 } } }, "connectors" : [ { "edgeId" : 31272, "type" : "INPUT", "segments" : [ { "from" : { "x" : 488, "y" : 1049 }, "to" : { "x" : 518, "y" : 1068 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 31275, "reactomeId" : 10296230, "displayName" : "SKP1:CUL1:FBXL5", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 608, "y" : 1070 }, "minX" : 553, "maxX" : 708, "minY" : 1053, "maxY" : 1081, "prop" : { "x" : 553, "y" : 1059, "width" : 111, "height" : 22 }, "textPosition" : { "x" : 569, "y" : 1046 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 664, "y" : 1059 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 664, "y" : 1059 } } }, "connectors" : [ { "edgeId" : 31272, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 31276, "type" : "INPUT", "segments" : [ { "from" : { "x" : 667, "y" : 1070 }, "to" : { "x" : 708, "y" : 1070 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 31277, "reactomeId" : 10296043, "displayName" : "NEDD8", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 654, "y" : 1122 }, "minX" : 629, "maxX" : 708, "minY" : 1070, "maxY" : 1133, "prop" : { "x" : 629, "y" : 1111, "width" : 51, "height" : 22 }, "textPosition" : { "x" : 629, "y" : 1111 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 680, "y" : 1111 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 680, "y" : 1111 } } }, "connectors" : [ { "edgeId" : 31276, "type" : "INPUT", "segments" : [ { "from" : { "x" : 665, "y" : 1108 }, "to" : { "x" : 708, "y" : 1070 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 31278, "reactomeId" : 10296232, "displayName" : "SKP1:FBXL5:CUL1:NEDD8", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 812, "y" : 1071 }, "minX" : 755, "maxX" : 876, "minY" : 1011, "maxY" : 1089, "prop" : { "x" : 755, "y" : 1053, "width" : 115, "height" : 36 }, "textPosition" : { "x" : 769, "y" : 1054 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 870, "y" : 1053 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 870, "y" : 1053 } } }, "connectors" : [ { "edgeId" : 31276, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 31279, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 812, "y" : 1050 }, "to" : { "x" : 813, "y" : 1019 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 813, "y" : 1015 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 813, "y" : 1015 } } } ] }, { "id" : 31280, "reactomeId" : 10226816, "displayName" : "Ub", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 863, "y" : 950 }, "minX" : 845, "maxX" : 876, "minY" : 939, "maxY" : 1003, "prop" : { "x" : 851, "y" : 939, "width" : 25, "height" : 22 }, "textPosition" : { "x" : 851, "y" : 939 }, "connectors" : [ { "edgeId" : 31279, "type" : "INPUT", "segments" : [ { "from" : { "x" : 859, "y" : 967 }, "to" : { "x" : 845, "y" : 1003 } } ], "stoichiometry" : { "value" : 3, "shape" : { "a" : { "x" : 846, "y" : 979 }, "b" : { "x" : 858, "y" : 991 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 852, "y" : 985 } } } } ] }, { "id" : 31281, "reactomeId" : 10296122, "displayName" : "IREB2", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 901, "y" : 1003 }, "minX" : 845, "maxX" : 928, "minY" : 986, "maxY" : 1014, "prop" : { "x" : 880, "y" : 992, "width" : 42, "height" : 22 }, "textPosition" : { "x" : 883, "y" : 986 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 922, "y" : 992 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 922, "y" : 992 } } }, "connectors" : [ { "edgeId" : 31279, "type" : "INPUT", "segments" : [ { "from" : { "x" : 877, "y" : 1003 }, "to" : { "x" : 845, "y" : 1003 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 31282, "reactomeId" : 10296228, "displayName" : "IREB2", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 727, "y" : 1004 }, "minX" : 687, "maxX" : 773, "minY" : 987, "maxY" : 1015, "prop" : { "x" : 687, "y" : 993, "width" : 80, "height" : 22 }, "textPosition" : { "x" : 705, "y" : 993 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 767, "y" : 993 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 767, "y" : 993 } } }, "connectors" : [ { "edgeId" : 31279, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 31289, "reactomeId" : 10296124, "displayName" : "ACO1, IREB2", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 974, "y" : 1090 }, "minX" : 933, "maxX" : 1016, "minY" : 1079, "maxY" : 1101, "prop" : { "x" : 933, "y" : 1079, "width" : 83, "height" : 22 }, "textPosition" : { "x" : 950, "y" : 1073 }, "connectors" : [ ] }, { "id" : 31291, "reactomeId" : 10330151, "displayName" : "Metabolism of cofactors", "schemaClass" : "Pathway", "renderableClass" : "EncapsulatedNode", "position" : { "x" : 1254, "y" : 970 }, "minX" : 1198, "maxX" : 1310, "minY" : 932, "maxY" : 1009, "prop" : { "x" : 1198, "y" : 932, "width" : 112, "height" : 77 }, "textPosition" : { "x" : 1200, "y" : 949 }, "connectors" : [ ] }, { "id" : 31179, "reactomeId" : 912516, "displayName" : "Fe3+", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 898, "y" : 155 }, "minX" : 317, "maxX" : 973, "minY" : 56, "maxY" : 205, "prop" : { "x" : 874, "y" : 140, "width" : 48, "height" : 30 }, "textPosition" : { "x" : 877, "y" : 144 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 917, "y" : 145 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 917, "y" : 145 } } }, "connectors" : [ { "edgeId" : 31178, "type" : "INPUT", "segments" : [ { "from" : { "x" : 891, "y" : 137 }, "to" : { "x" : 857, "y" : 62 } }, { "from" : { "x" : 857, "y" : 62 }, "to" : { "x" : 317, "y" : 56 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 31250, "type" : "INPUT", "segments" : [ { "from" : { "x" : 925, "y" : 164 }, "to" : { "x" : 973, "y" : 185 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 31193, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 875, "y" : 137 }, "to" : { "x" : 819, "y" : 103 } }, { "from" : { "x" : 819, "y" : 103 }, "to" : { "x" : 584, "y" : 99 } } ], "stoichiometry" : { "value" : 4, "shape" : { "a" : { "x" : 841, "y" : 114 }, "b" : { "x" : 853, "y" : 126 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 847, "y" : 120 } } }, "endShape" : { "a" : { "x" : 867, "y" : 137 }, "b" : { "x" : 875, "y" : 137 }, "c" : { "x" : 871, "y" : 130 }, "type" : "ARROW", "centre" : { "x" : 871, "y" : 130 } } }, { "edgeId" : 31197, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 871, "y" : 169 }, "to" : { "x" : 815, "y" : 205 } } ], "stoichiometry" : { "value" : 4, "shape" : { "a" : { "x" : 837, "y" : 181 }, "b" : { "x" : 849, "y" : 193 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 843, "y" : 187 } } }, "endShape" : { "a" : { "x" : 867, "y" : 176 }, "b" : { "x" : 871, "y" : 169 }, "c" : { "x" : 863, "y" : 169 }, "type" : "ARROW", "centre" : { "x" : 863, "y" : 169 } } } ] }, { "id" : 31180, "reactomeId" : 917828, "displayName" : "e-", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 299, "y" : 16 }, "minX" : 284, "maxX" : 317, "minY" : 0, "maxY" : 56, "prop" : { "x" : 284, "y" : 1, "width" : 31, "height" : 30 }, "textPosition" : { "x" : 289, "y" : 5 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 310, "y" : 6 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 310, "y" : 6 } } }, "connectors" : [ { "edgeId" : 31178, "type" : "INPUT", "segments" : [ { "from" : { "x" : 305, "y" : 34 }, "to" : { "x" : 317, "y" : 56 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 31181, "reactomeId" : 435347, "displayName" : "Fe2+", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 295, "y" : 165 }, "minX" : 249, "maxX" : 320, "minY" : 149, "maxY" : 232, "prop" : { "x" : 271, "y" : 150, "width" : 48, "height" : 30 }, "textPosition" : { "x" : 274, "y" : 154 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 314, "y" : 155 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 314, "y" : 155 } } }, "connectors" : [ { "edgeId" : 31178, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 31183, "type" : "INPUT", "segments" : [ { "from" : { "x" : 284, "y" : 183 }, "to" : { "x" : 249, "y" : 232 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 31191, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 31182, "reactomeId" : 10262111, "displayName" : "CYBRD1:Heme", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 102, "y" : 282 }, "minX" : 55, "maxX" : 309, "minY" : 78, "maxY" : 293, "prop" : { "x" : 55, "y" : 271, "width" : 94, "height" : 22 }, "textPosition" : { "x" : 72, "y" : 258 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 149, "y" : 271 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 149, "y" : 271 } } }, "connectors" : [ { "edgeId" : 31178, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 110, "y" : 268 }, "to" : { "x" : 255, "y" : 81 } }, { "from" : { "x" : 255, "y" : 81 }, "to" : { "x" : 301, "y" : 82 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 305, "y" : 82 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 305, "y" : 82 } } } ] }, { "id" : 31184, "reactomeId" : 351626, "displayName" : "H+", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 242, "y" : 182 }, "minX" : 224, "maxX" : 261, "minY" : 166, "maxY" : 232, "prop" : { "x" : 224, "y" : 167, "width" : 36, "height" : 30 }, "textPosition" : { "x" : 228, "y" : 171 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 255, "y" : 172 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 255, "y" : 172 } } }, "connectors" : [ { "edgeId" : 31183, "type" : "INPUT", "segments" : [ { "from" : { "x" : 244, "y" : 200 }, "to" : { "x" : 249, "y" : 232 } } ], "stoichiometry" : { "value" : 1 } } ], "trivial" : true }, { "id" : 31185, "reactomeId" : 71067, "displayName" : "Fe2+", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 294, "y" : 392 }, "minX" : 249, "maxX" : 502, "minY" : 324, "maxY" : 525, "prop" : { "x" : 270, "y" : 377, "width" : 48, "height" : 30 }, "textPosition" : { "x" : 273, "y" : 381 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 313, "y" : 382 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 313, "y" : 382 } } }, "connectors" : [ { "edgeId" : 31202, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 293, "y" : 410 }, "to" : { "x" : 293, "y" : 525 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 297, "y" : 417 }, "b" : { "x" : 293, "y" : 410 }, "c" : { "x" : 289, "y" : 417 }, "type" : "ARROW", "centre" : { "x" : 289, "y" : 417 } } }, { "edgeId" : 31243, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 31245, "type" : "INPUT", "segments" : [ { "from" : { "x" : 321, "y" : 397 }, "to" : { "x" : 502, "y" : 438 } } ], "stoichiometry" : { "value" : 4, "shape" : { "a" : { "x" : 405, "y" : 411 }, "b" : { "x" : 417, "y" : 423 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 411, "y" : 417 } } } }, { "edgeId" : 31183, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 284, "y" : 374 }, "to" : { "x" : 249, "y" : 324 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 277, "y" : 371 }, "b" : { "x" : 284, "y" : 374 }, "c" : { "x" : 283, "y" : 366 }, "type" : "ARROW", "centre" : { "x" : 283, "y" : 366 } } }, { "edgeId" : 31188, "type" : "INPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 31191, "type" : "INPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 31186, "reactomeId" : 70106, "displayName" : "H+", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 216, "y" : 390 }, "minX" : 198, "maxX" : 249, "minY" : 324, "maxY" : 405, "prop" : { "x" : 198, "y" : 375, "width" : 36, "height" : 30 }, "textPosition" : { "x" : 202, "y" : 379 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 229, "y" : 380 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 229, "y" : 380 } } }, "connectors" : [ { "edgeId" : 31183, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 223, "y" : 372 }, "to" : { "x" : 249, "y" : 324 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 223, "y" : 364 }, "b" : { "x" : 223, "y" : 372 }, "c" : { "x" : 230, "y" : 368 }, "type" : "ARROW", "centre" : { "x" : 230, "y" : 368 } } } ], "trivial" : true }, { "id" : 31187, "reactomeId" : 10257002, "displayName" : "SLC11A2", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 188, "y" : 283 }, "minX" : 158, "maxX" : 241, "minY" : 266, "maxY" : 294, "prop" : { "x" : 158, "y" : 272, "width" : 61, "height" : 22 }, "textPosition" : { "x" : 161, "y" : 266 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 219, "y" : 272 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 219, "y" : 272 } } }, "connectors" : [ { "edgeId" : 31183, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 222, "y" : 282 }, "to" : { "x" : 233, "y" : 282 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 237, "y" : 282 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 237, "y" : 282 } } } ] }, { "id" : 31189, "reactomeId" : 435347, "displayName" : "Fe2+", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 603, "y" : 234 }, "minX" : 530, "maxX" : 710, "minY" : 204, "maxY" : 249, "prop" : { "x" : 579, "y" : 219, "width" : 48, "height" : 30 }, "textPosition" : { "x" : 582, "y" : 223 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 622, "y" : 224 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 622, "y" : 224 } } }, "connectors" : [ { "edgeId" : 31188, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 31193, "type" : "INPUT", "segments" : [ { "from" : { "x" : 576, "y" : 224 }, "to" : { "x" : 530, "y" : 205 } } ], "stoichiometry" : { "value" : 4, "shape" : { "a" : { "x" : 547, "y" : 208 }, "b" : { "x" : 559, "y" : 220 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 553, "y" : 214 } } } }, { "edgeId" : 31197, "type" : "INPUT", "segments" : [ { "from" : { "x" : 630, "y" : 227 }, "to" : { "x" : 710, "y" : 204 } } ], "stoichiometry" : { "value" : 4, "shape" : { "a" : { "x" : 664, "y" : 209 }, "b" : { "x" : 676, "y" : 221 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 670, "y" : 215 } } } } ] }, { "id" : 31190, "reactomeId" : 10257123, "displayName" : "SLC40A1:HEPH:6Cu2+", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 773, "y" : 282 }, "minX" : 671, "maxX" : 830, "minY" : 213, "maxY" : 300, "prop" : { "x" : 723, "y" : 264, "width" : 101, "height" : 36 }, "textPosition" : { "x" : 729, "y" : 265 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 824, "y" : 264 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 824, "y" : 264 } } }, "connectors" : [ { "edgeId" : 31188, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 720, "y" : 281 }, "to" : { "x" : 679, "y" : 281 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 675, "y" : 281 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 675, "y" : 281 } } }, { "edgeId" : 31197, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 773, "y" : 261 }, "to" : { "x" : 774, "y" : 221 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 774, "y" : 217 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 774, "y" : 217 } } } ] }, { "id" : 31192, "reactomeId" : 10261116, "displayName" : "SLC40A1:CP:6Cu2+", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 479, "y" : 281 }, "minX" : 302, "maxX" : 548, "minY" : 211, "maxY" : 292, "prop" : { "x" : 417, "y" : 270, "width" : 125, "height" : 22 }, "textPosition" : { "x" : 436, "y" : 257 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 542, "y" : 270 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 542, "y" : 270 } } }, "connectors" : [ { "edgeId" : 31191, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 414, "y" : 281 }, "to" : { "x" : 310, "y" : 283 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 306, "y" : 283 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 306, "y" : 283 } } }, { "edgeId" : 31193, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 479, "y" : 267 }, "to" : { "x" : 481, "y" : 219 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 481, "y" : 215 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 481, "y" : 215 } } } ] }, { "id" : 31194, "reactomeId" : 352327, "displayName" : "O2", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 604, "y" : 192 }, "minX" : 530, "maxX" : 710, "minY" : 176, "maxY" : 207, "prop" : { "x" : 587, "y" : 177, "width" : 34, "height" : 30 }, "textPosition" : { "x" : 591, "y" : 181 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 616, "y" : 182 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 616, "y" : 182 } } }, "connectors" : [ { "edgeId" : 31193, "type" : "INPUT", "segments" : [ { "from" : { "x" : 584, "y" : 194 }, "to" : { "x" : 530, "y" : 205 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 31197, "type" : "INPUT", "segments" : [ { "from" : { "x" : 624, "y" : 193 }, "to" : { "x" : 710, "y" : 204 } } ], "stoichiometry" : { "value" : 1 } } ], "trivial" : true }, { "id" : 31195, "reactomeId" : 351626, "displayName" : "H+", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 606, "y" : 154 }, "minX" : 530, "maxX" : 710, "minY" : 138, "maxY" : 205, "prop" : { "x" : 588, "y" : 139, "width" : 36, "height" : 30 }, "textPosition" : { "x" : 592, "y" : 143 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 619, "y" : 144 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 619, "y" : 144 } } }, "connectors" : [ { "edgeId" : 31193, "type" : "INPUT", "segments" : [ { "from" : { "x" : 585, "y" : 166 }, "to" : { "x" : 530, "y" : 205 } } ], "stoichiometry" : { "value" : 4, "shape" : { "a" : { "x" : 551, "y" : 179 }, "b" : { "x" : 563, "y" : 191 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 557, "y" : 185 } } } }, { "edgeId" : 31197, "type" : "INPUT", "segments" : [ { "from" : { "x" : 627, "y" : 162 }, "to" : { "x" : 710, "y" : 204 } } ], "stoichiometry" : { "value" : 4, "shape" : { "a" : { "x" : 662, "y" : 177 }, "b" : { "x" : 674, "y" : 189 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 668, "y" : 183 } } } } ], "trivial" : true }, { "id" : 31196, "reactomeId" : 109276, "displayName" : "H2O", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 764, "y" : 137 }, "minX" : 584, "maxX" : 815, "minY" : 99, "maxY" : 205, "prop" : { "x" : 743, "y" : 122, "width" : 43, "height" : 30 }, "textPosition" : { "x" : 747, "y" : 126 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 781, "y" : 127 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 781, "y" : 127 } } }, "connectors" : [ { "edgeId" : 31193, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 740, "y" : 132 }, "to" : { "x" : 584, "y" : 99 } } ], "stoichiometry" : { "value" : 2, "shape" : { "a" : { "x" : 656, "y" : 109 }, "b" : { "x" : 668, "y" : 121 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 662, "y" : 115 } } }, "endShape" : { "a" : { "x" : 732, "y" : 134 }, "b" : { "x" : 740, "y" : 132 }, "c" : { "x" : 734, "y" : 127 }, "type" : "ARROW", "centre" : { "x" : 734, "y" : 127 } } }, { "edgeId" : 31197, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 775, "y" : 155 }, "to" : { "x" : 815, "y" : 205 } } ], "stoichiometry" : { "value" : 2, "shape" : { "a" : { "x" : 789, "y" : 174 }, "b" : { "x" : 801, "y" : 186 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 795, "y" : 180 } } }, "endShape" : { "a" : { "x" : 782, "y" : 158 }, "b" : { "x" : 775, "y" : 155 }, "c" : { "x" : 776, "y" : 163 }, "type" : "ARROW", "centre" : { "x" : 776, "y" : 163 } } } ], "trivial" : true }, { "id" : 31199, "reactomeId" : 9707310, "displayName" : "Hemes", "schemaClass" : "CandidateSet", "renderableClass" : "EntitySet", "position" : { "x" : 37, "y" : 1123 }, "minX" : 11, "maxX" : 64, "minY" : 1107, "maxY" : 1140, "prop" : { "x" : 11, "y" : 1107, "width" : 53, "height" : 33 }, "textPosition" : { "x" : 12, "y" : 1113 }, "connectors" : [ { "edgeId" : 31198, "type" : "INPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 31200, "reactomeId" : 9707308, "displayName" : "Hemes", "schemaClass" : "CandidateSet", "renderableClass" : "EntitySet", "position" : { "x" : 190, "y" : 1123 }, "minX" : 165, "maxX" : 216, "minY" : 1107, "maxY" : 1140, "prop" : { "x" : 165, "y" : 1107, "width" : 51, "height" : 33 }, "textPosition" : { "x" : 165, "y" : 1113 }, "connectors" : [ { "edgeId" : 31198, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 31201, "reactomeId" : 10244361, "displayName" : "SLC46A1", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 108, "y" : 1173 }, "minX" : 78, "maxX" : 145, "minY" : 1131, "maxY" : 1184, "prop" : { "x" : 78, "y" : 1162, "width" : 61, "height" : 22 }, "textPosition" : { "x" : 81, "y" : 1156 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 139, "y" : 1162 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 139, "y" : 1162 } } }, "connectors" : [ { "edgeId" : 31198, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 108, "y" : 1159 }, "to" : { "x" : 108, "y" : 1139 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 108, "y" : 1135 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 108, "y" : 1135 } } } ] }, { "id" : 31203, "reactomeId" : 29364, "displayName" : "NADPH", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 360, "y" : 674 }, "minX" : 292, "maxX" : 391, "minY" : 638, "maxY" : 689, "prop" : { "x" : 331, "y" : 659, "width" : 59, "height" : 30 }, "textPosition" : { "x" : 335, "y" : 663 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 385, "y" : 664 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 385, "y" : 664 } } }, "connectors" : [ { "edgeId" : 31202, "type" : "INPUT", "segments" : [ { "from" : { "x" : 331, "y" : 656 }, "to" : { "x" : 292, "y" : 638 } } ], "stoichiometry" : { "value" : 3, "shape" : { "a" : { "x" : 305, "y" : 641 }, "b" : { "x" : 317, "y" : 653 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 311, "y" : 647 } } } } ] }, { "id" : 31204, "reactomeId" : 71185, "displayName" : "ferroheme", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 293, "y" : 706 }, "minX" : 105, "maxX" : 319, "minY" : 638, "maxY" : 804, "prop" : { "x" : 269, "y" : 691, "width" : 49, "height" : 30 }, "textPosition" : { "x" : 270, "y" : 689 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 313, "y" : 696 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 313, "y" : 696 } } }, "connectors" : [ { "edgeId" : 31202, "type" : "INPUT", "segments" : [ { "from" : { "x" : 292, "y" : 688 }, "to" : { "x" : 292, "y" : 638 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 31211, "type" : "INPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 31214, "type" : "INPUT", "segments" : [ { "from" : { "x" : 266, "y" : 718 }, "to" : { "x" : 105, "y" : 804 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 31205, "reactomeId" : 29368, "displayName" : "O2", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 244, "y" : 667 }, "minX" : 227, "maxX" : 292, "minY" : 638, "maxY" : 682, "prop" : { "x" : 227, "y" : 652, "width" : 34, "height" : 30 }, "textPosition" : { "x" : 231, "y" : 656 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 256, "y" : 657 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 256, "y" : 657 } } }, "connectors" : [ { "edgeId" : 31202, "type" : "INPUT", "segments" : [ { "from" : { "x" : 264, "y" : 656 }, "to" : { "x" : 292, "y" : 638 } } ], "stoichiometry" : { "value" : 3, "shape" : { "a" : { "x" : 272, "y" : 641 }, "b" : { "x" : 284, "y" : 653 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 278, "y" : 647 } } } } ], "trivial" : true }, { "id" : 31206, "reactomeId" : 189396, "displayName" : "BV", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 248, "y" : 460 }, "minX" : 232, "maxX" : 293, "minY" : 444, "maxY" : 525, "prop" : { "x" : 232, "y" : 445, "width" : 32, "height" : 30 }, "textPosition" : { "x" : 236, "y" : 449 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 259, "y" : 450 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 259, "y" : 450 } } }, "connectors" : [ { "edgeId" : 31202, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 258, "y" : 478 }, "to" : { "x" : 293, "y" : 525 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 265, "y" : 481 }, "b" : { "x" : 258, "y" : 478 }, "c" : { "x" : 259, "y" : 486 }, "type" : "ARROW", "centre" : { "x" : 259, "y" : 486 } } } ] }, { "id" : 31207, "reactomeId" : 189385, "displayName" : "CO", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 329, "y" : 466 }, "minX" : 293, "maxX" : 347, "minY" : 450, "maxY" : 525, "prop" : { "x" : 312, "y" : 451, "width" : 34, "height" : 30 }, "textPosition" : { "x" : 316, "y" : 455 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 341, "y" : 456 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 341, "y" : 456 } } }, "connectors" : [ { "edgeId" : 31202, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 319, "y" : 484 }, "to" : { "x" : 293, "y" : 525 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 319, "y" : 492 }, "b" : { "x" : 319, "y" : 484 }, "c" : { "x" : 312, "y" : 488 }, "type" : "ARROW", "centre" : { "x" : 312, "y" : 488 } } } ] }, { "id" : 31208, "reactomeId" : 29366, "displayName" : "NADP+", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 373, "y" : 497 }, "minX" : 293, "maxX" : 404, "minY" : 481, "maxY" : 525, "prop" : { "x" : 343, "y" : 482, "width" : 60, "height" : 30 }, "textPosition" : { "x" : 347, "y" : 486 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 398, "y" : 487 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 398, "y" : 487 } } }, "connectors" : [ { "edgeId" : 31202, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 340, "y" : 507 }, "to" : { "x" : 293, "y" : 525 } } ], "stoichiometry" : { "value" : 3, "shape" : { "a" : { "x" : 310, "y" : 510 }, "b" : { "x" : 322, "y" : 522 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 316, "y" : 516 } } }, "endShape" : { "a" : { "x" : 335, "y" : 513 }, "b" : { "x" : 340, "y" : 507 }, "c" : { "x" : 332, "y" : 506 }, "type" : "ARROW", "centre" : { "x" : 332, "y" : 506 } } } ] }, { "id" : 31209, "reactomeId" : 29356, "displayName" : "H2O", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 220, "y" : 500 }, "minX" : 199, "maxX" : 293, "minY" : 484, "maxY" : 525, "prop" : { "x" : 199, "y" : 485, "width" : 43, "height" : 30 }, "textPosition" : { "x" : 203, "y" : 489 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 237, "y" : 490 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 237, "y" : 490 } } }, "connectors" : [ { "edgeId" : 31202, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 245, "y" : 507 }, "to" : { "x" : 293, "y" : 525 } } ], "stoichiometry" : { "value" : 3, "shape" : { "a" : { "x" : 263, "y" : 510 }, "b" : { "x" : 275, "y" : 522 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 269, "y" : 516 } } }, "endShape" : { "a" : { "x" : 253, "y" : 506 }, "b" : { "x" : 245, "y" : 507 }, "c" : { "x" : 250, "y" : 513 }, "type" : "ARROW", "centre" : { "x" : 250, "y" : 513 } } } ], "trivial" : true }, { "id" : 31210, "reactomeId" : 10241418, "displayName" : "HMOX1 dimer, HMOX2", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 416, "y" : 570 }, "minX" : 301, "maxX" : 465, "minY" : 555, "maxY" : 585, "prop" : { "x" : 367, "y" : 555, "width" : 98, "height" : 30 }, "textPosition" : { "x" : 367, "y" : 553 }, "connectors" : [ { "edgeId" : 31202, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 361, "y" : 570 }, "to" : { "x" : 309, "y" : 570 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 305, "y" : 570 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 305, "y" : 570 } } } ] }, { "id" : 31212, "reactomeId" : 917877, "displayName" : "heme", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 24, "y" : 822 }, "minX" : 0, "maxX" : 107, "minY" : 804, "maxY" : 837, "prop" : { "x" : 0, "y" : 807, "width" : 49, "height" : 30 }, "textPosition" : { "x" : 3, "y" : 811 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 44, "y" : 812 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 44, "y" : 812 } } }, "connectors" : [ { "edgeId" : 31211, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 31214, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 52, "y" : 816 }, "to" : { "x" : 107, "y" : 804 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 58, "y" : 811 }, "b" : { "x" : 52, "y" : 816 }, "c" : { "x" : 60, "y" : 818 }, "type" : "ARROW", "centre" : { "x" : 60, "y" : 818 } } } ] }, { "id" : 31213, "reactomeId" : 10262147, "displayName" : "FLVCR1", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 105, "y" : 909 }, "minX" : 71, "maxX" : 145, "minY" : 892, "maxY" : 948, "prop" : { "x" : 71, "y" : 898, "width" : 68, "height" : 22 }, "textPosition" : { "x" : 78, "y" : 898 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 139, "y" : 898 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 139, "y" : 898 } } }, "connectors" : [ { "edgeId" : 31211, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 105, "y" : 923 }, "to" : { "x" : 105, "y" : 940 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 105, "y" : 944 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 105, "y" : 944 } } } ] }, { "id" : 31215, "reactomeId" : 113592, "displayName" : "ATP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 196, "y" : 716 }, "minX" : 105, "maxX" : 217, "minY" : 700, "maxY" : 804, "prop" : { "x" : 176, "y" : 701, "width" : 40, "height" : 30 }, "textPosition" : { "x" : 180, "y" : 705 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 211, "y" : 706 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 211, "y" : 706 } } }, "connectors" : [ { "edgeId" : 31214, "type" : "INPUT", "segments" : [ { "from" : { "x" : 180, "y" : 734 }, "to" : { "x" : 105, "y" : 804 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 31216, "reactomeId" : 29356, "displayName" : "H2O", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 252, "y" : 754 }, "minX" : 105, "maxX" : 275, "minY" : 738, "maxY" : 804, "prop" : { "x" : 231, "y" : 739, "width" : 43, "height" : 30 }, "textPosition" : { "x" : 235, "y" : 743 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 269, "y" : 744 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 269, "y" : 744 } } }, "connectors" : [ { "edgeId" : 31214, "type" : "INPUT", "segments" : [ { "from" : { "x" : 228, "y" : 761 }, "to" : { "x" : 105, "y" : 804 } } ], "stoichiometry" : { "value" : 1 } } ], "trivial" : true }, { "id" : 31217, "reactomeId" : 29370, "displayName" : "ADP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 190, "y" : 879 }, "minX" : 107, "maxX" : 211, "minY" : 804, "maxY" : 895, "prop" : { "x" : 171, "y" : 864, "width" : 39, "height" : 31 }, "textPosition" : { "x" : 174, "y" : 869 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 205, "y" : 869 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 205, "y" : 869 } } }, "connectors" : [ { "edgeId" : 31214, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 172, "y" : 861 }, "to" : { "x" : 107, "y" : 804 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 164, "y" : 859 }, "b" : { "x" : 172, "y" : 861 }, "c" : { "x" : 169, "y" : 853 }, "type" : "ARROW", "centre" : { "x" : 169, "y" : 853 } } } ] }, { "id" : 31218, "reactomeId" : 29372, "displayName" : "Pi", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 230, "y" : 845 }, "minX" : 107, "maxX" : 245, "minY" : 804, "maxY" : 860, "prop" : { "x" : 217, "y" : 830, "width" : 27, "height" : 30 }, "textPosition" : { "x" : 221, "y" : 834 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 239, "y" : 835 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 239, "y" : 835 } } }, "connectors" : [ { "edgeId" : 31214, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 214, "y" : 840 }, "to" : { "x" : 107, "y" : 804 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 206, "y" : 842 }, "b" : { "x" : 214, "y" : 840 }, "c" : { "x" : 209, "y" : 834 }, "type" : "ARROW", "centre" : { "x" : 209, "y" : 834 } } } ] }, { "id" : 31219, "reactomeId" : 70106, "displayName" : "H+", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 231, "y" : 806 }, "minX" : 107, "maxX" : 250, "minY" : 790, "maxY" : 821, "prop" : { "x" : 213, "y" : 791, "width" : 36, "height" : 30 }, "textPosition" : { "x" : 217, "y" : 795 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 244, "y" : 796 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 244, "y" : 796 } } }, "connectors" : [ { "edgeId" : 31214, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 210, "y" : 805 }, "to" : { "x" : 107, "y" : 804 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 203, "y" : 809 }, "b" : { "x" : 210, "y" : 805 }, "c" : { "x" : 203, "y" : 801 }, "type" : "ARROW", "centre" : { "x" : 203, "y" : 801 } } } ], "trivial" : true }, { "id" : 31220, "reactomeId" : 10262167, "displayName" : "ABCG2 tetramer", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 104, "y" : 711 }, "minX" : 67, "maxX" : 147, "minY" : 686, "maxY" : 796, "prop" : { "x" : 67, "y" : 692, "width" : 74, "height" : 39 }, "textPosition" : { "x" : 72, "y" : 696 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 141, "y" : 692 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 141, "y" : 692 } } }, "connectors" : [ { "edgeId" : 31214, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 104, "y" : 734 }, "to" : { "x" : 106, "y" : 788 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 106, "y" : 792 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 106, "y" : 792 } } } ] }, { "id" : 31222, "reactomeId" : 10296251, "displayName" : "HFE", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 1599, "y" : 283 }, "minX" : 1584, "maxX" : 1621, "minY" : 239, "maxY" : 294, "prop" : { "x" : 1584, "y" : 272, "width" : 31, "height" : 22 }, "textPosition" : { "x" : 1587, "y" : 266 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1615, "y" : 272 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1615, "y" : 272 } } }, "connectors" : [ { "edgeId" : 31221, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1596, "y" : 269 }, "to" : { "x" : 1589, "y" : 239 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 31223, "reactomeId" : 10262174, "displayName" : "TFRC dimer", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 1534, "y" : 283 }, "minX" : 1496, "maxX" : 1589, "minY" : 239, "maxY" : 294, "prop" : { "x" : 1496, "y" : 272, "width" : 77, "height" : 22 }, "textPosition" : { "x" : 1496, "y" : 273 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1573, "y" : 272 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1573, "y" : 272 } } }, "connectors" : [ { "edgeId" : 31221, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1547, "y" : 269 }, "to" : { "x" : 1589, "y" : 239 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 31224, "reactomeId" : 10296253, "displayName" : "HFE:TFRC dimer", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 1678, "y" : 281 }, "minX" : 1627, "maxX" : 1736, "minY" : 264, "maxY" : 292, "prop" : { "x" : 1627, "y" : 270, "width" : 103, "height" : 22 }, "textPosition" : { "x" : 1643, "y" : 257 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1730, "y" : 270 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1730, "y" : 270 } } }, "connectors" : [ { "edgeId" : 31221, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 31226, "reactomeId" : 10231121, "displayName" : "ATP6AP1", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 1010, "y" : 743 }, "minX" : 959, "maxX" : 1048, "minY" : 687, "maxY" : 754, "prop" : { "x" : 979, "y" : 732, "width" : 63, "height" : 22 }, "textPosition" : { "x" : 979, "y" : 732 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1042, "y" : 732 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1042, "y" : 732 } } }, "connectors" : [ { "edgeId" : 31225, "type" : "INPUT", "segments" : [ { "from" : { "x" : 999, "y" : 729 }, "to" : { "x" : 959, "y" : 687 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 31227, "reactomeId" : 10231117, "displayName" : "V-ATPase", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 1109, "y" : 741 }, "minX" : 959, "maxX" : 1149, "minY" : 687, "maxY" : 752, "prop" : { "x" : 1076, "y" : 730, "width" : 67, "height" : 22 }, "textPosition" : { "x" : 1076, "y" : 731 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1143, "y" : 730 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1143, "y" : 730 } } }, "connectors" : [ { "edgeId" : 31225, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1078, "y" : 727 }, "to" : { "x" : 959, "y" : 687 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 31228, "reactomeId" : 10231123, "displayName" : "V-ATPase:ATP6AP1", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 823, "y" : 738 }, "minX" : 761, "maxX" : 892, "minY" : 721, "maxY" : 821, "prop" : { "x" : 761, "y" : 727, "width" : 125, "height" : 22 }, "textPosition" : { "x" : 761, "y" : 728 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 886, "y" : 727 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 886, "y" : 727 } } }, "connectors" : [ { "edgeId" : 31225, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 31229, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 822, "y" : 752 }, "to" : { "x" : 822, "y" : 813 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 822, "y" : 817 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 822, "y" : 817 } } } ] }, { "id" : 31230, "reactomeId" : 113592, "displayName" : "ATP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 923, "y" : 810 }, "minX" : 858, "maxX" : 944, "minY" : 794, "maxY" : 829, "prop" : { "x" : 903, "y" : 795, "width" : 40, "height" : 30 }, "textPosition" : { "x" : 907, "y" : 799 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 938, "y" : 800 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 938, "y" : 800 } } }, "connectors" : [ { "edgeId" : 31229, "type" : "INPUT", "segments" : [ { "from" : { "x" : 900, "y" : 815 }, "to" : { "x" : 858, "y" : 829 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 31231, "reactomeId" : 29356, "displayName" : "H2O", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 883, "y" : 783 }, "minX" : 858, "maxX" : 906, "minY" : 767, "maxY" : 829, "prop" : { "x" : 862, "y" : 768, "width" : 43, "height" : 30 }, "textPosition" : { "x" : 866, "y" : 772 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 900, "y" : 773 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 900, "y" : 773 } } }, "connectors" : [ { "edgeId" : 31229, "type" : "INPUT", "segments" : [ { "from" : { "x" : 874, "y" : 801 }, "to" : { "x" : 858, "y" : 829 } } ], "stoichiometry" : { "value" : 1 } } ], "trivial" : true } ], "edges" : [ { "id" : 31202, "reactomeId" : 10241421, "displayName" : "HMOX1 dimer, HMOX2 cleave heme", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 293, "y" : 570 }, "minX" : 287, "maxX" : 299, "minY" : 525, "maxY" : 638, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 292, "y" : 638 }, "to" : { "x" : 293, "y" : 570 } }, { "from" : { "x" : 293, "y" : 570 }, "to" : { "x" : 293, "y" : 525 } } ], "reactionShape" : { "a" : { "x" : 287, "y" : 564 }, "b" : { "x" : 299, "y" : 576 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 293, "y" : 570 } }, "inputs" : [ { "id" : 31203, "points" : [ { "x" : 331, "y" : 656 } ], "stoichiometry" : 3 }, { "id" : 31204, "points" : [ { "x" : 292, "y" : 688 } ] }, { "id" : 31205, "points" : [ { "x" : 264, "y" : 656 } ], "stoichiometry" : 3 } ], "outputs" : [ { "id" : 31185, "points" : [ { "x" : 293, "y" : 410 } ] }, { "id" : 31206, "points" : [ { "x" : 258, "y" : 478 } ] }, { "id" : 31207, "points" : [ { "x" : 319, "y" : 484 } ] }, { "id" : 31208, "points" : [ { "x" : 340, "y" : 507 } ], "stoichiometry" : 3 }, { "id" : 31209, "points" : [ { "x" : 245, "y" : 507 } ], "stoichiometry" : 3 } ], "catalysts" : [ { "id" : 31210, "points" : [ { "x" : 361, "y" : 570 } ] } ] }, { "id" : 31236, "reactomeId" : 10262135, "displayName" : "STEAP3,STEAP4 reduce Fe3+ to Fe2+", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 1183, "y" : 491 }, "minX" : 1177, "maxX" : 1189, "minY" : 442, "maxY" : 536, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 1182, "y" : 442 }, "to" : { "x" : 1183, "y" : 491 } }, { "from" : { "x" : 1183, "y" : 491 }, "to" : { "x" : 1184, "y" : 536 } } ], "reactionShape" : { "a" : { "x" : 1177, "y" : 485 }, "b" : { "x" : 1189, "y" : 497 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1183, "y" : 491 } }, "inputs" : [ { "id" : 31237, "points" : [ { "x" : 1247, "y" : 399 } ] }, { "id" : 31238, "points" : [ { "x" : 1154, "y" : 426 } ] } ], "outputs" : [ { "id" : 31239, "points" : [ { "x" : 1171, "y" : 583 } ] }, { "id" : 31240, "points" : [ { "x" : 1105, "y" : 572 } ] }, { "id" : 31241, "points" : [ { "x" : 1211, "y" : 556 } ] } ], "catalysts" : [ { "id" : 31242, "points" : [ { "x" : 1114, "y" : 490 } ] } ] }, { "id" : 31268, "reactomeId" : 10296243, "displayName" : "CANDI binds CUL1", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 359, "y" : 1034 }, "minX" : 314, "maxX" : 365, "minY" : 1028, "maxY" : 1040, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 358, "y" : 1033 }, "to" : { "x" : 359, "y" : 1034 } }, { "from" : { "x" : 359, "y" : 1034 }, "to" : { "x" : 314, "y" : 1034 } } ], "endShape" : { "a" : { "x" : 321, "y" : 1030 }, "b" : { "x" : 314, "y" : 1034 }, "c" : { "x" : 321, "y" : 1038 }, "type" : "ARROW", "centre" : { "x" : 321, "y" : 1038 } }, "reactionShape" : { "c" : { "x" : 359, "y" : 1034 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 359, "y" : 1034 } }, "inputs" : [ { "id" : 31269, "points" : [ { "x" : 394, "y" : 1054 } ] }, { "id" : 31270, "points" : [ { "x" : 391, "y" : 1010 } ] } ], "outputs" : [ { "id" : 31271 } ] }, { "id" : 31272, "reactomeId" : 10296257, "displayName" : "CUL1, SKP1, FBXL5 bind", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 518, "y" : 1069 }, "minX" : 512, "maxX" : 550, "minY" : 1063, "maxY" : 1075, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 518, "y" : 1068 }, "to" : { "x" : 518, "y" : 1069 } }, { "from" : { "x" : 518, "y" : 1069 }, "to" : { "x" : 550, "y" : 1069 } } ], "endShape" : { "a" : { "x" : 543, "y" : 1073 }, "b" : { "x" : 550, "y" : 1069 }, "c" : { "x" : 543, "y" : 1065 }, "type" : "ARROW", "centre" : { "x" : 543, "y" : 1065 } }, "reactionShape" : { "c" : { "x" : 518, "y" : 1069 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 518, "y" : 1069 } }, "inputs" : [ { "id" : 31269, "points" : [ { "x" : 434, "y" : 1068 } ] }, { "id" : 31273, "points" : [ { "x" : 488, "y" : 1088 } ] }, { "id" : 31274, "points" : [ { "x" : 488, "y" : 1049 } ] } ], "outputs" : [ { "id" : 31275 } ] }, { "id" : 31178, "reactomeId" : 10262114, "displayName" : "CYBRD1:Heme reduces Fe3+ to Fe2+", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 317, "y" : 82 }, "minX" : 298, "maxX" : 323, "minY" : 56, "maxY" : 147, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 317, "y" : 56 }, "to" : { "x" : 317, "y" : 82 } }, { "from" : { "x" : 317, "y" : 82 }, "to" : { "x" : 298, "y" : 147 } } ], "endShape" : { "a" : { "x" : 296, "y" : 139 }, "b" : { "x" : 298, "y" : 147 }, "c" : { "x" : 304, "y" : 141 }, "type" : "ARROW", "centre" : { "x" : 304, "y" : 141 } }, "reactionShape" : { "a" : { "x" : 311, "y" : 76 }, "b" : { "x" : 323, "y" : 88 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 317, "y" : 82 } }, "inputs" : [ { "id" : 31179, "points" : [ { "x" : 891, "y" : 137 }, { "x" : 857, "y" : 62 } ] }, { "id" : 31180, "points" : [ { "x" : 305, "y" : 34 } ] } ], "outputs" : [ { "id" : 31181 } ], "catalysts" : [ { "id" : 31182, "points" : [ { "x" : 110, "y" : 268 }, { "x" : 255, "y" : 81 } ] } ] }, { "id" : 31243, "reactomeId" : 10262160, "displayName" : "MCOLN1 transports Fe2+ from endosome lumen to cytosol", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 614, "y" : 585 }, "minX" : 313, "maxX" : 1051, "minY" : 410, "maxY" : 591, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 1051, "y" : 583 }, "to" : { "x" : 614, "y" : 585 } }, { "from" : { "x" : 614, "y" : 585 }, "to" : { "x" : 480, "y" : 538 } }, { "from" : { "x" : 480, "y" : 538 }, "to" : { "x" : 313, "y" : 410 } } ], "endShape" : { "a" : { "x" : 321, "y" : 411 }, "b" : { "x" : 313, "y" : 410 }, "c" : { "x" : 316, "y" : 417 }, "type" : "ARROW", "centre" : { "x" : 316, "y" : 417 } }, "reactionShape" : { "a" : { "x" : 608, "y" : 579 }, "b" : { "x" : 620, "y" : 591 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 614, "y" : 585 } }, "inputs" : [ { "id" : 31240 } ], "outputs" : [ { "id" : 31185 } ], "catalysts" : [ { "id" : 31244, "points" : [ { "x" : 614, "y" : 621 } ] } ] }, { "id" : 31211, "reactomeId" : 10262150, "displayName" : "FLVCR1-1 transports heme from cytosol to extracellular region", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 105, "y" : 956 }, "minX" : 23, "maxX" : 292, "minY" : 724, "maxY" : 962, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 292, "y" : 724 }, "to" : { "x" : 292, "y" : 956 } }, { "from" : { "x" : 292, "y" : 956 }, "to" : { "x" : 105, "y" : 956 } }, { "from" : { "x" : 105, "y" : 956 }, "to" : { "x" : 23, "y" : 956 } }, { "from" : { "x" : 23, "y" : 956 }, "to" : { "x" : 23, "y" : 840 } } ], "endShape" : { "a" : { "x" : 27, "y" : 847 }, "b" : { "x" : 23, "y" : 840 }, "c" : { "x" : 19, "y" : 847 }, "type" : "ARROW", "centre" : { "x" : 19, "y" : 847 } }, "reactionShape" : { "a" : { "x" : 99, "y" : 950 }, "b" : { "x" : 111, "y" : 962 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 105, "y" : 956 } }, "inputs" : [ { "id" : 31204 } ], "outputs" : [ { "id" : 31212 } ], "catalysts" : [ { "id" : 31213, "points" : [ { "x" : 105, "y" : 923 } ] } ] }, { "id" : 31276, "reactomeId" : 10296259, "displayName" : "NEDD8 binds CUL1 (in SKP1:CUL1:FXBL5)", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 708, "y" : 1071 }, "minX" : 702, "maxX" : 752, "minY" : 1065, "maxY" : 1077, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 708, "y" : 1070 }, "to" : { "x" : 708, "y" : 1071 } }, { "from" : { "x" : 708, "y" : 1071 }, "to" : { "x" : 752, "y" : 1071 } } ], "endShape" : { "a" : { "x" : 745, "y" : 1075 }, "b" : { "x" : 752, "y" : 1071 }, "c" : { "x" : 745, "y" : 1067 }, "type" : "ARROW", "centre" : { "x" : 745, "y" : 1067 } }, "reactionShape" : { "c" : { "x" : 708, "y" : 1071 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 708, "y" : 1071 } }, "inputs" : [ { "id" : 31275, "points" : [ { "x" : 667, "y" : 1070 } ] }, { "id" : 31277, "points" : [ { "x" : 665, "y" : 1108 } ] } ], "outputs" : [ { "id" : 31278 } ] }, { "id" : 31245, "reactomeId" : 10269154, "displayName" : "Ferritin Complex oxidises 4Fe2+ to Fe(3+)O(OH)", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 568, "y" : 438 }, "minX" : 502, "maxX" : 655, "minY" : 432, "maxY" : 444, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 502, "y" : 438 }, "to" : { "x" : 568, "y" : 438 } }, { "from" : { "x" : 568, "y" : 438 }, "to" : { "x" : 655, "y" : 438 } } ], "endShape" : { "a" : { "x" : 648, "y" : 442 }, "b" : { "x" : 655, "y" : 438 }, "c" : { "x" : 648, "y" : 434 }, "type" : "ARROW", "centre" : { "x" : 648, "y" : 434 } }, "reactionShape" : { "a" : { "x" : 562, "y" : 432 }, "b" : { "x" : 574, "y" : 444 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 568, "y" : 438 } }, "inputs" : [ { "id" : 31185, "points" : [ { "x" : 321, "y" : 397 } ], "stoichiometry" : 4 }, { "id" : 31246, "points" : [ { "x" : 484, "y" : 407 } ], "stoichiometry" : 4 }, { "id" : 31247, "points" : [ { "x" : 488, "y" : 458 } ], "stoichiometry" : 4 } ], "outputs" : [ { "id" : 31248, "stoichiometry" : 4 } ], "catalysts" : [ { "id" : 31249, "points" : [ { "x" : 568, "y" : 397 } ] } ] }, { "id" : 31214, "reactomeId" : 10262170, "displayName" : "ABCG2 tetramer transports heme from cytosol to extracellular region", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 106, "y" : 804 }, "minX" : 99, "maxX" : 111, "minY" : 798, "maxY" : 810, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 105, "y" : 804 }, "to" : { "x" : 106, "y" : 804 } }, { "from" : { "x" : 106, "y" : 804 }, "to" : { "x" : 107, "y" : 804 } } ], "reactionShape" : { "a" : { "x" : 100, "y" : 798 }, "b" : { "x" : 112, "y" : 810 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 106, "y" : 804 } }, "inputs" : [ { "id" : 31215, "points" : [ { "x" : 180, "y" : 734 } ] }, { "id" : 31216, "points" : [ { "x" : 228, "y" : 761 } ] }, { "id" : 31204, "points" : [ { "x" : 266, "y" : 718 } ] } ], "outputs" : [ { "id" : 31212, "points" : [ { "x" : 52, "y" : 816 } ] }, { "id" : 31217, "points" : [ { "x" : 172, "y" : 861 } ] }, { "id" : 31218, "points" : [ { "x" : 214, "y" : 840 } ] }, { "id" : 31219, "points" : [ { "x" : 210, "y" : 805 } ] } ], "catalysts" : [ { "id" : 31220, "points" : [ { "x" : 104, "y" : 734 } ] } ] }, { "id" : 31183, "reactomeId" : 10257005, "displayName" : "SLC11A2 cotransports Fe2+, H+ from extracellular region to cytosol", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 249, "y" : 282 }, "minX" : 243, "maxX" : 255, "minY" : 232, "maxY" : 324, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 249, "y" : 232 }, "to" : { "x" : 249, "y" : 282 } }, { "from" : { "x" : 249, "y" : 282 }, "to" : { "x" : 249, "y" : 324 } } ], "reactionShape" : { "a" : { "x" : 243, "y" : 276 }, "b" : { "x" : 255, "y" : 288 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 249, "y" : 282 } }, "inputs" : [ { "id" : 31184, "points" : [ { "x" : 244, "y" : 200 } ] }, { "id" : 31181, "points" : [ { "x" : 284, "y" : 183 } ] } ], "outputs" : [ { "id" : 31185, "points" : [ { "x" : 284, "y" : 374 } ] }, { "id" : 31186, "points" : [ { "x" : 223, "y" : 372 } ] } ], "catalysts" : [ { "id" : 31187, "points" : [ { "x" : 222, "y" : 282 } ] } ] }, { "id" : 31279, "reactomeId" : 10296235, "displayName" : "SKP1:FBXL5:CUL1:NEDD8 ubiquitinylates IREB2", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 813, "y" : 1003 }, "minX" : 770, "maxX" : 845, "minY" : 997, "maxY" : 1009, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 845, "y" : 1003 }, "to" : { "x" : 813, "y" : 1003 } }, { "from" : { "x" : 813, "y" : 1003 }, "to" : { "x" : 770, "y" : 1003 } } ], "endShape" : { "a" : { "x" : 777, "y" : 999 }, "b" : { "x" : 770, "y" : 1003 }, "c" : { "x" : 777, "y" : 1007 }, "type" : "ARROW", "centre" : { "x" : 777, "y" : 1007 } }, "reactionShape" : { "a" : { "x" : 807, "y" : 997 }, "b" : { "x" : 819, "y" : 1009 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 813, "y" : 1003 } }, "inputs" : [ { "id" : 31280, "points" : [ { "x" : 859, "y" : 967 } ], "stoichiometry" : 3 }, { "id" : 31281, "points" : [ { "x" : 877, "y" : 1003 } ] } ], "outputs" : [ { "id" : 31282 } ], "catalysts" : [ { "id" : 31278, "points" : [ { "x" : 812, "y" : 1050 } ] } ] }, { "id" : 31250, "reactomeId" : 10286904, "displayName" : "LCN2:2,5DHBA binds Fe3+", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 972, "y" : 187 }, "minX" : 966, "maxX" : 1010, "minY" : 181, "maxY" : 193, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 973, "y" : 185 }, "to" : { "x" : 972, "y" : 187 } }, { "from" : { "x" : 972, "y" : 187 }, "to" : { "x" : 1010, "y" : 185 } } ], "endShape" : { "a" : { "x" : 1003, "y" : 189 }, "b" : { "x" : 1010, "y" : 185 }, "c" : { "x" : 1003, "y" : 181 }, "type" : "ARROW", "centre" : { "x" : 1003, "y" : 181 } }, "reactionShape" : { "c" : { "x" : 972, "y" : 187 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 972, "y" : 187 } }, "inputs" : [ { "id" : 31251, "points" : [ { "x" : 958, "y" : 207 } ] }, { "id" : 31179, "points" : [ { "x" : 925, "y" : 164 } ] } ], "outputs" : [ { "id" : 31252 } ] }, { "id" : 31188, "reactomeId" : 10257126, "displayName" : "SLC40A1:HEPH:6Cu2+ transports Fe2+ from cytosol to extracellular region", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 663, "y" : 281 }, "minX" : 321, "maxX" : 669, "minY" : 252, "maxY" : 384, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 321, "y" : 384 }, "to" : { "x" : 663, "y" : 281 } }, { "from" : { "x" : 663, "y" : 281 }, "to" : { "x" : 622, "y" : 252 } } ], "endShape" : { "a" : { "x" : 630, "y" : 253 }, "b" : { "x" : 622, "y" : 252 }, "c" : { "x" : 625, "y" : 259 }, "type" : "ARROW", "centre" : { "x" : 625, "y" : 259 } }, "reactionShape" : { "a" : { "x" : 657, "y" : 275 }, "b" : { "x" : 669, "y" : 287 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 663, "y" : 281 } }, "inputs" : [ { "id" : 31185 } ], "outputs" : [ { "id" : 31189 } ], "catalysts" : [ { "id" : 31190, "points" : [ { "x" : 720, "y" : 281 } ] } ] }, { "id" : 31221, "reactomeId" : 10296255, "displayName" : "HFE binds TFRC dimer", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 1590, "y" : 239 }, "minX" : 1584, "maxX" : 1654, "minY" : 233, "maxY" : 267, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 1589, "y" : 239 }, "to" : { "x" : 1590, "y" : 239 } }, { "from" : { "x" : 1590, "y" : 239 }, "to" : { "x" : 1654, "y" : 267 } } ], "endShape" : { "a" : { "x" : 1646, "y" : 268 }, "b" : { "x" : 1654, "y" : 267 }, "c" : { "x" : 1649, "y" : 261 }, "type" : "ARROW", "centre" : { "x" : 1649, "y" : 261 } }, "reactionShape" : { "c" : { "x" : 1590, "y" : 239 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 1590, "y" : 239 } }, "inputs" : [ { "id" : 31222, "points" : [ { "x" : 1596, "y" : 269 } ] }, { "id" : 31223, "points" : [ { "x" : 1547, "y" : 269 } ] } ], "outputs" : [ { "id" : 31224 } ] }, { "id" : 31253, "reactomeId" : 10292688, "displayName" : "Fe3+ dissociates from SLC22A17:LCN2:2,5DHBA", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 1132, "y" : 344 }, "minX" : 1126, "maxX" : 1206, "minY" : 305, "maxY" : 350, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 1129, "y" : 305 }, "to" : { "x" : 1132, "y" : 344 } }, { "from" : { "x" : 1132, "y" : 344 }, "to" : { "x" : 1206, "y" : 344 } } ], "reactionShape" : { "a" : { "x" : 1126, "y" : 338 }, "b" : { "x" : 1138, "y" : 350 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1132, "y" : 344 } }, "inputs" : [ { "id" : 31254 } ], "outputs" : [ { "id" : 31255, "points" : [ { "x" : 1258, "y" : 302 } ] }, { "id" : 31237, "points" : [ { "x" : 1242, "y" : 366 } ] } ], "catalysts" : [ { "id" : 31256, "points" : [ { "x" : 1022, "y" : 293 }, { "x" : 1069, "y" : 344 } ] } ] }, { "id" : 31191, "reactomeId" : 10261119, "displayName" : "SLC40A1:CP:6Cu2+ transports Fe2+ from cytosol to extracellular region", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 294, "y" : 283 }, "minX" : 288, "maxX" : 300, "minY" : 183, "maxY" : 374, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 294, "y" : 374 }, "to" : { "x" : 294, "y" : 283 } }, { "from" : { "x" : 294, "y" : 283 }, "to" : { "x" : 294, "y" : 183 } } ], "endShape" : { "a" : { "x" : 298, "y" : 190 }, "b" : { "x" : 294, "y" : 183 }, "c" : { "x" : 290, "y" : 190 }, "type" : "ARROW", "centre" : { "x" : 290, "y" : 190 } }, "reactionShape" : { "a" : { "x" : 288, "y" : 277 }, "b" : { "x" : 300, "y" : 289 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 294, "y" : 283 } }, "inputs" : [ { "id" : 31185 } ], "outputs" : [ { "id" : 31181 } ], "catalysts" : [ { "id" : 31192, "points" : [ { "x" : 414, "y" : 281 } ] } ] }, { "id" : 31193, "reactomeId" : 10262143, "displayName" : "SLC40A1:CP:6Cu2+ oxidises Fe2+ to Fe3+", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 481, "y" : 203 }, "minX" : 475, "maxX" : 584, "minY" : 99, "maxY" : 209, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 530, "y" : 205 }, "to" : { "x" : 481, "y" : 203 } }, { "from" : { "x" : 481, "y" : 203 }, "to" : { "x" : 584, "y" : 99 } } ], "reactionShape" : { "a" : { "x" : 475, "y" : 197 }, "b" : { "x" : 487, "y" : 209 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 481, "y" : 203 } }, "inputs" : [ { "id" : 31194, "points" : [ { "x" : 584, "y" : 194 } ] }, { "id" : 31189, "points" : [ { "x" : 576, "y" : 224 } ], "stoichiometry" : 4 }, { "id" : 31195, "points" : [ { "x" : 585, "y" : 166 } ], "stoichiometry" : 4 } ], "outputs" : [ { "id" : 31179, "points" : [ { "x" : 875, "y" : 137 }, { "x" : 819, "y" : 103 } ], "stoichiometry" : 4 }, { "id" : 31196, "points" : [ { "x" : 740, "y" : 132 } ], "stoichiometry" : 2 } ], "catalysts" : [ { "id" : 31192, "points" : [ { "x" : 479, "y" : 267 } ] } ] }, { "id" : 31225, "reactomeId" : 10287311, "displayName" : "ATP6AP1 binds V-ATPase", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 905, "y" : 705 }, "minX" : 852, "maxX" : 965, "minY" : 681, "maxY" : 724, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 959, "y" : 687 }, "to" : { "x" : 905, "y" : 705 } }, { "from" : { "x" : 905, "y" : 705 }, "to" : { "x" : 852, "y" : 724 } } ], "endShape" : { "a" : { "x" : 857, "y" : 718 }, "b" : { "x" : 852, "y" : 724 }, "c" : { "x" : 860, "y" : 725 }, "type" : "ARROW", "centre" : { "x" : 860, "y" : 725 } }, "reactionShape" : { "c" : { "x" : 905, "y" : 705 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 905, "y" : 705 } }, "inputs" : [ { "id" : 31226, "points" : [ { "x" : 999, "y" : 729 } ] }, { "id" : 31227, "points" : [ { "x" : 1078, "y" : 727 } ] } ], "outputs" : [ { "id" : 31228 } ] }, { "id" : 31257, "reactomeId" : 10296225, "displayName" : "FTMT 24mer oxidises 4Fe2+ to 4Fe(3+)O(OH)", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 1539, "y" : 1039 }, "minX" : 1497, "maxX" : 1623, "minY" : 1033, "maxY" : 1045, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 1497, "y" : 1039 }, "to" : { "x" : 1539, "y" : 1039 } }, { "from" : { "x" : 1539, "y" : 1039 }, "to" : { "x" : 1623, "y" : 1039 } } ], "endShape" : { "a" : { "x" : 1616, "y" : 1043 }, "b" : { "x" : 1623, "y" : 1039 }, "c" : { "x" : 1616, "y" : 1035 }, "type" : "ARROW", "centre" : { "x" : 1616, "y" : 1035 } }, "reactionShape" : { "a" : { "x" : 1533, "y" : 1033 }, "b" : { "x" : 1545, "y" : 1045 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1539, "y" : 1039 } }, "inputs" : [ { "id" : 31258, "points" : [ { "x" : 1435, "y" : 999 } ], "stoichiometry" : 4 }, { "id" : 31259, "points" : [ { "x" : 1430, "y" : 1029 } ], "stoichiometry" : 4 }, { "id" : 31260, "points" : [ { "x" : 1431, "y" : 1061 } ], "stoichiometry" : 4 } ], "outputs" : [ { "id" : 31261, "stoichiometry" : 4 } ], "catalysts" : [ { "id" : 31262, "points" : [ { "x" : 1539, "y" : 1002 } ] } ] }, { "id" : 31229, "reactomeId" : 10262137, "displayName" : "Acidification of Tf:TfR1 containing endosome", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 822, "y" : 829 }, "minX" : 736, "maxX" : 858, "minY" : 823, "maxY" : 835, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 858, "y" : 829 }, "to" : { "x" : 822, "y" : 829 } }, { "from" : { "x" : 822, "y" : 829 }, "to" : { "x" : 736, "y" : 829 } } ], "reactionShape" : { "a" : { "x" : 816, "y" : 823 }, "b" : { "x" : 828, "y" : 835 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 822, "y" : 829 } }, "inputs" : [ { "id" : 31230, "points" : [ { "x" : 900, "y" : 815 } ] }, { "id" : 31231, "points" : [ { "x" : 874, "y" : 801 } ] }, { "id" : 31232, "points" : [ { "x" : 892, "y" : 845 } ], "stoichiometry" : 3 } ], "outputs" : [ { "id" : 31233, "points" : [ { "x" : 731, "y" : 709 } ], "stoichiometry" : 3 }, { "id" : 31234, "points" : [ { "x" : 694, "y" : 811 } ] }, { "id" : 31235, "points" : [ { "x" : 696, "y" : 844 } ] } ], "catalysts" : [ { "id" : 31228, "points" : [ { "x" : 822, "y" : 752 } ] } ] }, { "id" : 31197, "reactomeId" : 10262153, "displayName" : "SLC40A1:HEPH:6Cu2+ oxidises 4Fe2+ to 4Fe3+", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 774, "y" : 205 }, "minX" : 710, "maxX" : 815, "minY" : 199, "maxY" : 211, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 710, "y" : 204 }, "to" : { "x" : 774, "y" : 205 } }, { "from" : { "x" : 774, "y" : 205 }, "to" : { "x" : 815, "y" : 205 } } ], "reactionShape" : { "a" : { "x" : 768, "y" : 199 }, "b" : { "x" : 780, "y" : 211 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 774, "y" : 205 } }, "inputs" : [ { "id" : 31194, "points" : [ { "x" : 624, "y" : 193 } ] }, { "id" : 31195, "points" : [ { "x" : 627, "y" : 162 } ], "stoichiometry" : 4 }, { "id" : 31189, "points" : [ { "x" : 630, "y" : 227 } ], "stoichiometry" : 4 } ], "outputs" : [ { "id" : 31179, "points" : [ { "x" : 871, "y" : 169 } ], "stoichiometry" : 4 }, { "id" : 31196, "points" : [ { "x" : 775, "y" : 155 } ], "stoichiometry" : 2 } ], "catalysts" : [ { "id" : 31190, "points" : [ { "x" : 773, "y" : 261 } ] } ] }, { "id" : 31198, "reactomeId" : 10262140, "displayName" : "SLC46A1 transports hemes from extracellular region to cytosol", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 108, "y" : 1123 }, "minX" : 70, "maxX" : 159, "minY" : 1117, "maxY" : 1129, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 70, "y" : 1123 }, "to" : { "x" : 108, "y" : 1123 } }, { "from" : { "x" : 108, "y" : 1123 }, "to" : { "x" : 159, "y" : 1123 } } ], "endShape" : { "a" : { "x" : 152, "y" : 1127 }, "b" : { "x" : 159, "y" : 1123 }, "c" : { "x" : 152, "y" : 1119 }, "type" : "ARROW", "centre" : { "x" : 152, "y" : 1119 } }, "reactionShape" : { "a" : { "x" : 102, "y" : 1117 }, "b" : { "x" : 114, "y" : 1129 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 108, "y" : 1123 } }, "inputs" : [ { "id" : 31199 } ], "outputs" : [ { "id" : 31200 } ], "catalysts" : [ { "id" : 31201, "points" : [ { "x" : 108, "y" : 1159 } ] } ] }, { "id" : 31263, "reactomeId" : 10296118, "displayName" : "ACO1 binds 4Fe-4S", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 1024, "y" : 971 }, "minX" : 1018, "maxX" : 1067, "minY" : 965, "maxY" : 977, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 1023, "y" : 971 }, "to" : { "x" : 1024, "y" : 971 } }, { "from" : { "x" : 1024, "y" : 971 }, "to" : { "x" : 1067, "y" : 971 } } ], "endShape" : { "a" : { "x" : 1060, "y" : 975 }, "b" : { "x" : 1067, "y" : 971 }, "c" : { "x" : 1060, "y" : 967 }, "type" : "ARROW", "centre" : { "x" : 1060, "y" : 967 } }, "reactionShape" : { "a" : { "x" : 1018, "y" : 965 }, "b" : { "x" : 1030, "y" : 977 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1024, "y" : 971 } }, "inputs" : [ { "id" : 31264, "points" : [ { "x" : 994, "y" : 990 } ] }, { "id" : 31265, "points" : [ { "x" : 994, "y" : 941 } ] } ], "outputs" : [ { "id" : 31266 } ], "catalysts" : [ { "id" : 31264, "points" : [ { "x" : 979, "y" : 990 }, { "x" : 979, "y" : 971 } ] } ], "activators" : [ { "id" : 31267, "points" : [ { "x" : 1149, "y" : 1042 } ] } ] } ], "compartments" : [ { "id" : 31283, "reactomeId" : 70101, "displayName" : "cytosol", "schemaClass" : "Compartment", "renderableClass" : "Compartment", "position" : { "x" : 950, "y" : 786 }, "minX" : 100, "maxX" : 1800, "minY" : 277, "maxY" : 1296, "prop" : { "x" : 100, "y" : 277, "width" : 1700, "height" : 1019 }, "textPosition" : { "x" : 120, "y" : 301 }, "insets" : { "x" : 110, "y" : 287, "width" : 1680, "height" : 999 }, "bgColor" : { "r" : 250, "g" : 240, "b" : 240 }, "componentIds" : [ 31285, 31286, 31187, 31185, 31186, 31183, 31190, 31188, 31191, 31192, 31201, 31198, 31208, 31202, 31209, 31203, 31204, 31205, 31206, 31207, 31211, 31215, 31216, 31220, 31218, 31223, 31222, 31224, 31229, 31230, 31232, 31235, 31231, 31234, 31245, 31248, 31249, 31246, 31247, 31256, 31254, 31253, 31255, 31265, 31266, 31263, 31264, 31289, 31292, 31268, 31271, 31269, 31270, 31272, 31273, 31274, 31275, 31276, 31277, 31278, 31279, 31280, 31281, 31293, 31282, 31182, 31237, 31213, 31200, 31290, 31267, 31291, 31294, 31214, 31219, 31217, 31238 ] }, { "id" : 31284, "reactomeId" : 5460, "displayName" : "mitochondrial matrix", "schemaClass" : "Compartment", "renderableClass" : "Compartment", "position" : { "x" : 1554, "y" : 1023 }, "minX" : 1365, "maxX" : 1743, "minY" : 945, "maxY" : 1101, "prop" : { "x" : 1365, "y" : 945, "width" : 378, "height" : 156 }, "textPosition" : { "x" : 1440, "y" : 1053 }, "insets" : { "x" : 1375, "y" : 955, "width" : 358, "height" : 136 }, "bgColor" : { "r" : 250, "g" : 240, "b" : 240 }, "componentIds" : [ 31258, 31262, 31261, 31257, 31259, 31260 ] }, { "id" : 31285, "reactomeId" : 17927, "displayName" : "mitochondrial intermembrane space", "schemaClass" : "Compartment", "renderableClass" : "Compartment", "position" : { "x" : 1546, "y" : 1032 }, "minX" : 1322, "maxX" : 1771, "minY" : 927, "maxY" : 1138, "prop" : { "x" : 1322, "y" : 927, "width" : 449, "height" : 211 }, "textPosition" : { "x" : 1380, "y" : 1092 }, "insets" : { "x" : 1332, "y" : 937, "width" : 429, "height" : 191 }, "bgColor" : { "r" : 250, "g" : 240, "b" : 240 }, "componentIds" : [ 31284 ] }, { "id" : 31286, "reactomeId" : 171907, "displayName" : "endosome lumen", "schemaClass" : "Compartment", "renderableClass" : "Compartment", "position" : { "x" : 994, "y" : 616 }, "minX" : 609, "maxX" : 1379, "minY" : 487, "maxY" : 746, "prop" : { "x" : 609, "y" : 487, "width" : 770, "height" : 259 }, "textPosition" : { "x" : 928, "y" : 618 }, "insets" : { "x" : 619, "y" : 497, "width" : 750, "height" : 239 }, "bgColor" : { "r" : 250, "g" : 240, "b" : 240 }, "componentIds" : [ 31236, 31240, 31243, 31244, 31226, 31227, 31228, 31233, 31225, 31239, 31242, 31241 ] }, { "id" : 31290, "reactomeId" : 17957, "displayName" : "endoplasmic reticulum lumen", "schemaClass" : "Compartment", "renderableClass" : "Compartment", "position" : { "x" : 438, "y" : 604 }, "minX" : 372, "maxX" : 504, "minY" : 565, "maxY" : 644, "prop" : { "x" : 372, "y" : 565, "width" : 132, "height" : 79 }, "textPosition" : { "x" : 382, "y" : 581 }, "insets" : { "x" : 382, "y" : 575, "width" : 112, "height" : 59 }, "bgColor" : { "r" : 250, "g" : 240, "b" : 240 }, "componentIds" : [ 31210 ] } ], "notes" : [ ], "links" : [ { "id" : 31292, "renderableClass" : "EntitySetAndMemberLink", "position" : { "x" : 976, "y" : 1045 }, "minX" : 970, "maxX" : 982, "minY" : 1018, "maxY" : 1073, "segments" : [ { "from" : { "x" : 979, "y" : 1018 }, "to" : { "x" : 974, "y" : 1073 } } ], "reactionShape" : { "a" : { "x" : 970, "y" : 1039 }, "b" : { "x" : 982, "y" : 1051 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 976, "y" : 1045 } }, "inputs" : [ { "id" : 31264 } ], "outputs" : [ { "id" : 31289 } ] }, { "id" : 31293, "renderableClass" : "EntitySetAndMemberLink", "position" : { "x" : 937, "y" : 1045 }, "minX" : 910, "maxX" : 964, "minY" : 1017, "maxY" : 1073, "segments" : [ { "from" : { "x" : 910, "y" : 1017 }, "to" : { "x" : 964, "y" : 1073 } } ], "reactionShape" : { "a" : { "x" : 931, "y" : 1039 }, "b" : { "x" : 943, "y" : 1051 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 937, "y" : 1045 } }, "inputs" : [ { "id" : 31281 } ], "outputs" : [ { "id" : 31289 } ] }, { "id" : 31294, "renderableClass" : "Interaction", "position" : { "x" : 1178, "y" : 970 }, "minX" : 1161, "maxX" : 1195, "minY" : 964, "maxY" : 976, "interactionType" : "Activate", "segments" : [ { "from" : { "x" : 1161, "y" : 970 }, "to" : { "x" : 1195, "y" : 970 } } ], "endShape" : { "a" : { "x" : 1188, "y" : 974 }, "b" : { "x" : 1195, "y" : 970 }, "c" : { "x" : 1188, "y" : 966 }, "type" : "ARROW", "empty" : true, "centre" : { "x" : 1188, "y" : 966 } }, "reactionShape" : { "a" : { "x" : 1172, "y" : 964 }, "b" : { "x" : 1184, "y" : 976 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1178, "y" : 970 } }, "inputs" : [ { "id" : 31266 } ], "outputs" : [ { "id" : 31291 } ] } ], "shadows" : [ { "id" : 31295, "reactomeId" : 10330551, "displayName" : "Transferrin endocytosis and recycling", "schemaClass" : "Pathway", "renderableClass" : "Shadow", "position" : { "x" : 1000, "y" : 551 }, "minX" : 260, "maxX" : 1740, "minY" : 223, "maxY" : 879, "prop" : { "x" : 260, "y" : 223, "width" : 1480, "height" : 656 }, "points" : [ { "x" : 260, "y" : 223 }, { "x" : 1740, "y" : 223 }, { "x" : 1740, "y" : 879 }, { "x" : 260, "y" : 879 } ], "colour" : "#4684ee" } ], "minX" : 0, "maxX" : 1800, "minY" : 0, "maxY" : 1296, "disease" : false }