{
  "dbId" : 10329431,
  "stId" : "R-CFA-168643",
  "speciesName" : "Canis familiaris",
  "nodes" : [ {
    "dbId" : 10260376,
    "stId" : "R-CFA-622416",
    "displayName" : "Long prodomain caspases [cytosol]",
    "schemaClass" : "CandidateSet",
    "speciesId" : 49646,
    "diagramIds" : [ 97134 ],
    "parents" : [ 10260378 ],
    "children" : [ 10230616, 10234631, 10258167 ]
  }, {
    "dbId" : 10260378,
    "stId" : "R-CFA-622417",
    "displayName" : "NOD1:iE-DAP:Long prodomain caspases [cytosol]",
    "schemaClass" : "Complex",
    "speciesId" : 49646,
    "diagramIds" : [ 97135 ],
    "parents" : [ ],
    "children" : [ 10260376, 10238376 ]
  }, {
    "dbId" : 10260372,
    "stId" : "R-CFA-688994",
    "displayName" : "PAMP:NOD oligomer:RIP2:NEMO [cytosol]",
    "schemaClass" : "Complex",
    "speciesId" : 49646,
    "diagramIds" : [ 97116 ],
    "parents" : [ ],
    "children" : [ 10238278, 10238396 ]
  }, {
    "dbId" : 10258583,
    "stId" : "R-CFA-167998",
    "displayName" : "MAP2K6 [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 49646,
    "diagramIds" : [ 97182 ],
    "identifier" : "A0A8I3NBF5",
    "standardIdentifier" : "uniprot:A0A8I3NBF5",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "MAP2K6" ],
    "parents" : [ ],
    "children" : [ ]
  }, {
    "dbId" : 10260621,
    "stId" : "R-CFA-879207",
    "displayName" : "MDP:NLRP1:ATP [cytosol]",
    "schemaClass" : "Complex",
    "speciesId" : 49646,
    "diagramIds" : [ 97165 ],
    "parents" : [ 10260623 ],
    "children" : [ 113592, 10260619 ]
  }, {
    "dbId" : 10260623,
    "stId" : "R-CFA-1296412",
    "displayName" : "MDP:NLRP1:ATP oligomer [cytosol]",
    "schemaClass" : "Polymer",
    "speciesId" : 49646,
    "diagramIds" : [ 97167 ],
    "parents" : [ ],
    "children" : [ 10260621 ]
  }, {
    "dbId" : 10258568,
    "stId" : "R-CFA-706477",
    "displayName" : "PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO:activated TAK1 complex [cytosol]",
    "schemaClass" : "Complex",
    "speciesId" : 49646,
    "diagramIds" : [ 97132 ],
    "parents" : [ ],
    "children" : [ 10257953, 10258566 ]
  }, {
    "dbId" : 10260617,
    "stId" : "R-CFA-561196",
    "displayName" : "NLRP1 [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 49646,
    "diagramIds" : [ 97159 ],
    "identifier" : "A0A8I3MJ75",
    "standardIdentifier" : "uniprot:A0A8I3MJ75",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "NLRP1" ],
    "parents" : [ 10260802, 10260619 ],
    "children" : [ ]
  }, {
    "dbId" : 10260619,
    "stId" : "R-CFA-877370",
    "displayName" : "MDP:NLRP1 [cytosol]",
    "schemaClass" : "Complex",
    "speciesId" : 49646,
    "diagramIds" : [ 97162 ],
    "parents" : [ 10260621 ],
    "children" : [ 708341, 10260617 ]
  }, {
    "dbId" : 10258564,
    "stId" : "R-CFA-706482",
    "displayName" : "PAMP:NOD oligomer:K63-Ub-RIP2 [cytosol]",
    "schemaClass" : "Complex",
    "speciesId" : 49646,
    "parents" : [ 10258566 ],
    "children" : [ 10258562, 10238390 ]
  }, {
    "dbId" : 10258566,
    "stId" : "R-CFA-706480",
    "displayName" : "PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO [cytosol]",
    "schemaClass" : "Complex",
    "speciesId" : 49646,
    "diagramIds" : [ 97124 ],
    "parents" : [ 10260429, 10258568 ],
    "children" : [ 10238278, 10258564 ]
  }, {
    "dbId" : 10258562,
    "stId" : "R-CFA-706483",
    "displayName" : "RIPK2 [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 49646,
    "identifier" : "A0A8I3PFI5",
    "standardIdentifier" : "uniprot:A0A8I3PFI5",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "RIPK2" ],
    "parents" : [ 10258564 ],
    "children" : [ ]
  }, {
    "dbId" : 10238396,
    "stId" : "R-CFA-168409",
    "displayName" : "PAMP:NOD oligomer:RIP2 [cytosol]",
    "schemaClass" : "Complex",
    "speciesId" : 49646,
    "diagramIds" : [ 97113 ],
    "parents" : [ 10260482, 10260372 ],
    "children" : [ 10238390, 10238394 ]
  }, {
    "dbId" : 10238140,
    "stId" : "R-CFA-166366",
    "displayName" : "TRAF6 [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 49646,
    "identifier" : "A0A8I3P2V4",
    "standardIdentifier" : "uniprot:A0A8I3P2V4",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "TRAF6" ],
    "parents" : [ 10238490 ],
    "children" : [ ]
  }, {
    "dbId" : 10260409,
    "stId" : "R-CFA-688989",
    "displayName" : "TNFAIP3 [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 49646,
    "diagramIds" : [ 97127 ],
    "identifier" : "A0A8I3RUY7",
    "standardIdentifier" : "uniprot:A0A8I3RUY7",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "TNFAIP3" ],
    "parents" : [ ],
    "children" : [ ]
  }, {
    "dbId" : 10238394,
    "stId" : "R-CFA-168402",
    "displayName" : "RIPK2 [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 49646,
    "diagramIds" : [ 97111 ],
    "identifier" : "A0A8I3PFI5",
    "standardIdentifier" : "uniprot:A0A8I3PFI5",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "RIPK2" ],
    "parents" : [ 10238396 ],
    "children" : [ ]
  }, {
    "dbId" : 10238388,
    "stId" : "R-CFA-708350",
    "displayName" : "MDP:NOD2 oligomer [cytosol]",
    "schemaClass" : "Complex",
    "speciesId" : 49646,
    "diagramIds" : [ 97109 ],
    "parents" : [ 10238390 ],
    "children" : [ 10238386 ]
  }, {
    "dbId" : 10238390,
    "stId" : "R-CFA-708346",
    "displayName" : "PAMP:NOD oligomer [cytosol]",
    "schemaClass" : "DefinedSet",
    "speciesId" : 49646,
    "diagramIds" : [ 97112 ],
    "parents" : [ 10238396, 10258564 ],
    "children" : [ 10238388, 10238380 ]
  }, {
    "dbId" : 10238384,
    "stId" : "R-CFA-168411",
    "displayName" : "NOD2 [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 49646,
    "diagramIds" : [ 97103 ],
    "identifier" : "A0A8I3MJL0",
    "standardIdentifier" : "uniprot:A0A8I3MJL0",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "NOD2" ],
    "parents" : [ 10320067, 10238386 ],
    "children" : [ ]
  }, {
    "dbId" : 10238386,
    "stId" : "R-CFA-168414",
    "displayName" : "MDP:NOD2 [cytosol]",
    "schemaClass" : "Complex",
    "speciesId" : 49646,
    "diagramIds" : [ 97105 ],
    "parents" : [ 10238388 ],
    "children" : [ 708341, 10238384 ]
  }, {
    "dbId" : 10238380,
    "stId" : "R-CFA-622306",
    "displayName" : "NOD1:iE-DAP oligomer [cytosol]",
    "schemaClass" : "Complex",
    "speciesId" : 49646,
    "diagramIds" : [ 97107 ],
    "parents" : [ 10238390 ],
    "children" : [ 10238376 ]
  }, {
    "dbId" : 10256044,
    "stId" : "R-CFA-428935",
    "displayName" : "phospho-p-T180,Y182-MAPK14 [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 49646,
    "identifier" : "O02812",
    "standardIdentifier" : "uniprot:O02812",
    "referenceType" : "ReferenceGeneProduct",
    "parents" : [ 10266414 ],
    "children" : [ ]
  }, {
    "dbId" : 10249903,
    "stId" : "R-CFA-375344",
    "displayName" : "PANX1 [plasma membrane]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 49646,
    "identifier" : "A0A8I3PDQ2",
    "standardIdentifier" : "uniprot:A0A8I3PDQ2",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "PANX1" ],
    "parents" : [ 10260766 ],
    "children" : [ ]
  }, {
    "dbId" : 10238376,
    "stId" : "R-CFA-168408",
    "displayName" : "NOD1:iE-DAP [cytosol]",
    "schemaClass" : "Complex",
    "speciesId" : 49646,
    "diagramIds" : [ 97101 ],
    "parents" : [ 10260378, 10238380 ],
    "children" : [ 10238374, 622271 ]
  }, {
    "dbId" : 10256042,
    "stId" : "R-CFA-428933",
    "displayName" : "MAPK14 [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 49646,
    "identifier" : "O02812",
    "standardIdentifier" : "uniprot:O02812",
    "referenceType" : "ReferenceGeneProduct",
    "parents" : [ 10266408 ],
    "children" : [ ]
  }, {
    "dbId" : 10266533,
    "stId" : "R-CFA-1250277",
    "displayName" : "Thioredoxin:TXNIP [cytosol]",
    "schemaClass" : "Complex",
    "speciesId" : 49646,
    "diagramIds" : [ 97171 ],
    "parents" : [ ],
    "children" : [ 10266531, 10230129 ]
  }, {
    "dbId" : 10238374,
    "stId" : "R-CFA-168407",
    "displayName" : "NOD1 [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 49646,
    "diagramIds" : [ 97100 ],
    "identifier" : "A0A8I3PEL3",
    "standardIdentifier" : "uniprot:A0A8I3PEL3",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "NOD1" ],
    "parents" : [ 10238376 ],
    "children" : [ ]
  }, {
    "dbId" : 10266531,
    "stId" : "R-CFA-1250246",
    "displayName" : "TXNIP [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 49646,
    "diagramIds" : [ 97169 ],
    "identifier" : "A0A8I3NKV1",
    "standardIdentifier" : "uniprot:A0A8I3NKV1",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "TXNIP" ],
    "parents" : [ 10266533 ],
    "children" : [ ]
  }, {
    "dbId" : 10235097,
    "stId" : "R-CFA-877215",
    "displayName" : "P2RX7 [plasma membrane]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 49646,
    "identifier" : "A0A8I3PV78",
    "standardIdentifier" : "uniprot:A0A8I3PV78",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "P2RX7" ],
    "parents" : [ 10260759 ],
    "children" : [ ]
  }, {
    "dbId" : 10238426,
    "stId" : "R-CFA-939176",
    "displayName" : "UBA52 [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 49646,
    "identifier" : "P63050",
    "standardIdentifier" : "uniprot:P63050",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "UBA52" ],
    "parents" : [ 10238452 ],
    "children" : [ ]
  }, {
    "dbId" : 10238417,
    "stId" : "R-CFA-939224",
    "displayName" : "RPS27A [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 49646,
    "identifier" : "A0A8I3NFB9",
    "standardIdentifier" : "uniprot:A0A8I3NFB9",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "RPS27A" ],
    "parents" : [ 10238452 ],
    "children" : [ ]
  }, {
    "dbId" : 10260429,
    "stId" : "R-CFA-706478",
    "displayName" : "PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO:TAK1 complex [plasma membrane]",
    "schemaClass" : "Complex",
    "speciesId" : 49646,
    "diagramIds" : [ 97130 ],
    "parents" : [ ],
    "children" : [ 10258566, 10260427 ]
  }, {
    "dbId" : 10238414,
    "stId" : "R-CFA-939169",
    "displayName" : "Ub-63-UBA52(1-76) [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 49646,
    "identifier" : "A0A8I3PFZ3",
    "standardIdentifier" : "uniprot:A0A8I3PFZ3",
    "referenceType" : "ReferenceGeneProduct",
    "parents" : [ 10238452 ],
    "children" : [ ]
  }, {
    "dbId" : 10260425,
    "stId" : "R-CFA-8947969",
    "displayName" : "TAB2,TAB3 [plasma membrane]",
    "schemaClass" : "DefinedSet",
    "speciesId" : 49646,
    "parents" : [ 10260427 ],
    "children" : [ 10260423, 10245383 ]
  }, {
    "dbId" : 10238411,
    "stId" : "R-CFA-939248",
    "displayName" : "Ub-63-RPS27A(1-76) [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 49646,
    "identifier" : "A0A8I3NUE4",
    "standardIdentifier" : "uniprot:A0A8I3NUE4",
    "referenceType" : "ReferenceGeneProduct",
    "parents" : [ 10238452 ],
    "children" : [ ]
  }, {
    "dbId" : 10260427,
    "stId" : "R-CFA-8947970",
    "displayName" : "TAK1 complex [plasma membrane]",
    "schemaClass" : "Complex",
    "speciesId" : 49646,
    "diagramIds" : [ 97129 ],
    "parents" : [ 10260429 ],
    "children" : [ 10257939, 10257943, 10260425 ]
  }, {
    "dbId" : 10260423,
    "stId" : "R-CFA-446879",
    "displayName" : "TAB3 [plasma membrane]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 49646,
    "identifier" : "A0A8I3NMB6",
    "standardIdentifier" : "uniprot:A0A8I3NMB6",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "TAB3" ],
    "parents" : [ 10260425 ],
    "children" : [ ]
  }, {
    "dbId" : 10260416,
    "stId" : "R-CFA-975995",
    "displayName" : "ITCH [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 49646,
    "identifier" : "A0A8I3NYH6",
    "standardIdentifier" : "uniprot:A0A8I3NYH6",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "ITCH" ],
    "parents" : [ 10260418 ],
    "children" : [ ]
  }, {
    "dbId" : 10320067,
    "stId" : "R-CFA-9676152",
    "displayName" : "AAMP:NOD2 [cytosol]",
    "schemaClass" : "Complex",
    "speciesId" : 49646,
    "diagramIds" : [ 97189 ],
    "parents" : [ ],
    "children" : [ 10238384, 10240575 ]
  }, {
    "dbId" : 10260418,
    "stId" : "R-CFA-1248659",
    "displayName" : "RIP2 ubiquitin ligases [cytosol]",
    "schemaClass" : "CandidateSet",
    "speciesId" : 49646,
    "diagramIds" : [ 97125 ],
    "parents" : [ ],
    "children" : [ 10260416, 10232866, 10238490, 10232862 ]
  }, {
    "dbId" : 10259906,
    "stId" : "R-CFA-114236",
    "displayName" : "BCL2L1 [mitochondrial outer membrane]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 49646,
    "identifier" : "Q76LT7",
    "standardIdentifier" : "uniprot:Q76LT7",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "BCL2L1" ],
    "parents" : [ 10260800 ],
    "children" : [ ]
  }, {
    "dbId" : 10238452,
    "stId" : "R-CFA-450143",
    "displayName" : "K63-Ub [cytosol]",
    "schemaClass" : "DefinedSet",
    "speciesId" : 49646,
    "parents" : [ 10238454 ],
    "children" : [ 10238417, 10238411, 10238426, 10238414 ]
  }, {
    "dbId" : 10238454,
    "stId" : "R-CFA-450152",
    "displayName" : "K63polyUb [cytosol]",
    "schemaClass" : "Polymer",
    "speciesId" : 49646,
    "diagramIds" : [ 97118 ],
    "parents" : [ ],
    "children" : [ 10238452 ]
  }, {
    "dbId" : 10258167,
    "stId" : "R-CFA-448692",
    "displayName" : "CASP4 [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 49646,
    "diagramIds" : [ 97195 ],
    "identifier" : "A0A8I3MG12",
    "standardIdentifier" : "uniprot:A0A8I3MG12",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "CASP4" ],
    "parents" : [ 10260376 ],
    "children" : [ ]
  }, {
    "dbId" : 29804,
    "stId" : "R-ALL-29804",
    "displayName" : "K+ [cytosol]",
    "schemaClass" : "SimpleEntity",
    "speciesId" : 0,
    "diagramIds" : [ 97137 ],
    "identifier" : "29103",
    "standardIdentifier" : "chebi:29103",
    "referenceType" : "ReferenceMolecule",
    "parents" : [ ],
    "children" : [ ]
  }, {
    "dbId" : 877176,
    "stId" : "R-ALL-877176",
    "displayName" : "SiO2 [cytosol]",
    "schemaClass" : "SimpleEntity",
    "speciesId" : 0,
    "identifier" : "30563",
    "standardIdentifier" : "chebi:30563",
    "referenceType" : "ReferenceMolecule",
    "parents" : [ 877245 ],
    "children" : [ ]
  }, {
    "dbId" : 10257949,
    "stId" : "R-CFA-450264",
    "displayName" : "TAB3 [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 49646,
    "identifier" : "A0A8I3NMB6",
    "standardIdentifier" : "uniprot:A0A8I3NMB6",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "TAB3" ],
    "parents" : [ 10257951 ],
    "children" : [ ]
  }, {
    "dbId" : 10232862,
    "stId" : "R-CFA-50847",
    "displayName" : "BIRC2 [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 49646,
    "identifier" : "A0A8I3MDM0",
    "standardIdentifier" : "uniprot:A0A8I3MDM0",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "BIRC2" ],
    "parents" : [ 10260418 ],
    "children" : [ ]
  }, {
    "dbId" : 10260766,
    "stId" : "R-CFA-9855178",
    "displayName" : "PANX1 heptamer [plasma membrane]",
    "schemaClass" : "Complex",
    "speciesId" : 49646,
    "diagramIds" : [ 97141 ],
    "parents" : [ 10260768 ],
    "children" : [ 10249903 ]
  }, {
    "dbId" : 10257951,
    "stId" : "R-CFA-446874",
    "displayName" : "TAB2,TAB3 [cytosol]",
    "schemaClass" : "DefinedSet",
    "speciesId" : 49646,
    "parents" : [ 10257953 ],
    "children" : [ 10257945, 10257949 ]
  }, {
    "dbId" : 10238488,
    "stId" : "R-CFA-202463",
    "displayName" : "UBE2N:UBE2V1 [cytosol]",
    "schemaClass" : "Complex",
    "speciesId" : 49646,
    "parents" : [ 10238490 ],
    "children" : [ 10238482, 10238486 ]
  }, {
    "dbId" : 10257945,
    "stId" : "R-CFA-168117",
    "displayName" : "TAB2 [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 49646,
    "identifier" : "A0A8I3P4Z1",
    "standardIdentifier" : "uniprot:A0A8I3P4Z1",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "TAB2" ],
    "parents" : [ 10257951 ],
    "children" : [ ]
  }, {
    "dbId" : 10260761,
    "stId" : "R-CFA-877257",
    "displayName" : "ATP:P2X7 oligomer [plasma membrane]",
    "schemaClass" : "Complex",
    "speciesId" : 49646,
    "diagramIds" : [ 97139 ],
    "parents" : [ 10260768 ],
    "children" : [ 10260759 ]
  }, {
    "dbId" : 10238490,
    "stId" : "R-CFA-1248657",
    "displayName" : "TRAF6 E3/E2 ubiquitin ligase complex [cytosol]",
    "schemaClass" : "Complex",
    "speciesId" : 49646,
    "diagramIds" : [ 97120 ],
    "parents" : [ 10260418 ],
    "children" : [ 10238488, 10238140 ]
  }, {
    "dbId" : 10238486,
    "stId" : "R-CFA-205753",
    "displayName" : "UBE2V1 [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 49646,
    "identifier" : "E2R2I5",
    "standardIdentifier" : "uniprot:E2R2I5",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "UBE2V1" ],
    "parents" : [ 10238488 ],
    "children" : [ ]
  }, {
    "dbId" : 10257943,
    "stId" : "R-CFA-167923",
    "displayName" : "TAB1 [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 49646,
    "identifier" : "A0A8I3PLL0",
    "standardIdentifier" : "uniprot:A0A8I3PLL0",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "TAB1" ],
    "parents" : [ 10260427, 10257953 ],
    "children" : [ ]
  }, {
    "dbId" : 10260759,
    "stId" : "R-CFA-877166",
    "displayName" : "ATP:P2X7 [plasma membrane]",
    "schemaClass" : "Complex",
    "speciesId" : 49646,
    "parents" : [ 10260761 ],
    "children" : [ 114570, 10235097 ]
  }, {
    "dbId" : 114570,
    "stId" : "R-ALL-114570",
    "displayName" : "ATP [extracellular region]",
    "schemaClass" : "SimpleEntity",
    "speciesId" : 0,
    "identifier" : "30616",
    "standardIdentifier" : "chebi:30616",
    "referenceType" : "ReferenceMolecule",
    "parents" : [ 10260759 ],
    "children" : [ ]
  }, {
    "dbId" : 10238480,
    "stId" : "R-CFA-206072-2",
    "displayName" : "UBE2N [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 49646,
    "identifier" : "A0A8I3PGB2",
    "standardIdentifier" : "uniprot:A0A8I3PGB2",
    "referenceType" : "ReferenceGeneProduct",
    "parents" : [ 10238482 ],
    "children" : [ ]
  }, {
    "dbId" : 10260753,
    "stId" : "R-CFA-874086",
    "displayName" : "NLRP3:SUGT1:HSP90 [cytosol]",
    "schemaClass" : "Complex",
    "speciesId" : 49646,
    "diagramIds" : [ 97149 ],
    "parents" : [ ],
    "children" : [ 10260745, 10260751 ]
  }, {
    "dbId" : 10238482,
    "stId" : "R-CFA-206072-3",
    "displayName" : "Homologues of UBE2N [cytosol]",
    "schemaClass" : "DefinedSet",
    "speciesId" : 49646,
    "parents" : [ 10238488 ],
    "children" : [ 10238480, 10238478 ]
  }, {
    "dbId" : 10257939,
    "stId" : "R-CFA-168156",
    "displayName" : "MAP3K7 [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 49646,
    "identifier" : "A0A8I3N7L6",
    "standardIdentifier" : "uniprot:A0A8I3N7L6",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "MAP3K7" ],
    "parents" : [ 10260427, 10257953 ],
    "children" : [ ]
  }, {
    "dbId" : 74126,
    "stId" : "R-ALL-74126",
    "displayName" : "K+ [extracellular region]",
    "schemaClass" : "SimpleEntity",
    "speciesId" : 0,
    "diagramIds" : [ 97138 ],
    "identifier" : "29103",
    "standardIdentifier" : "chebi:29103",
    "referenceType" : "ReferenceMolecule",
    "parents" : [ ],
    "children" : [ ]
  }, {
    "dbId" : 10260749,
    "stId" : "R-CFA-874107",
    "displayName" : "SUGT1 [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 49646,
    "diagramIds" : [ 97144 ],
    "identifier" : "A0A8I3ND03",
    "standardIdentifier" : "uniprot:A0A8I3ND03",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "SUGT1" ],
    "parents" : [ 10260751 ],
    "children" : [ ]
  }, {
    "dbId" : 10238478,
    "stId" : "R-CFA-206072",
    "displayName" : "UBE2N [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 49646,
    "identifier" : "A0A8I3P6I7",
    "standardIdentifier" : "uniprot:A0A8I3P6I7",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "UBE2N" ],
    "parents" : [ 10238482 ],
    "children" : [ ]
  }, {
    "dbId" : 10260751,
    "stId" : "R-CFA-874112",
    "displayName" : "SUGT1:HSP90 [cytosol]",
    "schemaClass" : "Complex",
    "speciesId" : 49646,
    "diagramIds" : [ 97146 ],
    "parents" : [ 10260753 ],
    "children" : [ 10254679, 10260749 ]
  }, {
    "dbId" : 877209,
    "stId" : "R-ALL-877209",
    "displayName" : "HUA [cytosol]",
    "schemaClass" : "SimpleEntity",
    "speciesId" : 0,
    "identifier" : "132153",
    "standardIdentifier" : "chebi:132153",
    "referenceType" : "ReferenceMolecule",
    "parents" : [ 877245 ],
    "children" : [ ]
  }, {
    "dbId" : 10260745,
    "stId" : "R-CFA-561189",
    "displayName" : "NLRP3 [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 49646,
    "diagramIds" : [ 97148 ],
    "identifier" : "A0A8I3P020",
    "standardIdentifier" : "uniprot:A0A8I3P020",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "NLRP3" ],
    "parents" : [ 10260753, 10267220 ],
    "children" : [ ]
  }, {
    "dbId" : 10234631,
    "stId" : "R-CFA-57033",
    "displayName" : "CASP9 [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 49646,
    "identifier" : "A0A8I3MAP5",
    "standardIdentifier" : "uniprot:A0A8I3MAP5",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "CASP9" ],
    "parents" : [ 10260376 ],
    "children" : [ ]
  }, {
    "dbId" : 10245383,
    "stId" : "R-CFA-168116",
    "displayName" : "TAB2 [plasma membrane]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 49646,
    "identifier" : "A0A8I3P4Z1",
    "standardIdentifier" : "uniprot:A0A8I3P4Z1",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "TAB2" ],
    "parents" : [ 10260425 ],
    "children" : [ ]
  }, {
    "dbId" : 10260480,
    "stId" : "R-CFA-741397",
    "displayName" : "IKBKG [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 49646,
    "identifier" : "A0A8I3S792",
    "standardIdentifier" : "uniprot:A0A8I3S792",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "IKBKG" ],
    "parents" : [ 10260482 ],
    "children" : [ ]
  }, {
    "dbId" : 10260482,
    "stId" : "R-CFA-741389",
    "displayName" : "PAMP:NOD oligomer:RIP2:K63-Ub-K285-NEMO [cytosol]",
    "schemaClass" : "Complex",
    "speciesId" : 49646,
    "diagramIds" : [ 97119 ],
    "parents" : [ ],
    "children" : [ 10260480, 10238396 ]
  }, {
    "dbId" : 10260796,
    "stId" : "R-CFA-877352",
    "displayName" : "Pyrin trimer:ASC [cytosol]",
    "schemaClass" : "Complex",
    "speciesId" : 49646,
    "diagramIds" : [ 97153 ],
    "parents" : [ ],
    "children" : [ 10260790, 10260794 ]
  }, {
    "dbId" : 10240575,
    "stId" : "R-CFA-9674636",
    "displayName" : "AAMP [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 49646,
    "diagramIds" : [ 97188 ],
    "identifier" : "Q7YR70",
    "standardIdentifier" : "uniprot:Q7YR70",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "AAMP" ],
    "parents" : [ 10320067 ],
    "children" : [ ]
  }, {
    "dbId" : 10260794,
    "stId" : "R-CFA-561191",
    "displayName" : "PYCARD [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 49646,
    "diagramIds" : [ 97151 ],
    "identifier" : "A0A8I3RYZ8",
    "standardIdentifier" : "uniprot:A0A8I3RYZ8",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "PYCARD" ],
    "parents" : [ 10260796 ],
    "children" : [ ]
  }, {
    "dbId" : 10260788,
    "stId" : "R-CFA-877355",
    "displayName" : "MEFV [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 49646,
    "identifier" : "A0A8I3RQW6",
    "standardIdentifier" : "uniprot:A0A8I3RQW6",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "MEFV" ],
    "parents" : [ 10260790 ],
    "children" : [ ]
  }, {
    "dbId" : 10260790,
    "stId" : "R-CFA-879202",
    "displayName" : "Pyrin trimer [cytosol]",
    "schemaClass" : "Complex",
    "speciesId" : 49646,
    "diagramIds" : [ 97152 ],
    "parents" : [ 10260796, 10260812 ],
    "children" : [ 10260788 ]
  }, {
    "dbId" : 10266412,
    "stId" : "R-CFA-171022",
    "displayName" : "phospho-MAPK13 [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 49646,
    "identifier" : "A0A8I3NKJ3",
    "standardIdentifier" : "uniprot:A0A8I3NKJ3",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "MAPK13" ],
    "parents" : [ 10266414 ],
    "children" : [ ]
  }, {
    "dbId" : 10232876,
    "stId" : "R-CFA-741420",
    "displayName" : "CYLD [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 49646,
    "diagramIds" : [ 97122 ],
    "identifier" : "A0A8I3MSL4",
    "standardIdentifier" : "uniprot:A0A8I3MSL4",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "CYLD" ],
    "parents" : [ ],
    "children" : [ ]
  }, {
    "dbId" : 877245,
    "stId" : "R-ALL-877245",
    "displayName" : "NLRP3 elicitor small molecules [cytosol]",
    "schemaClass" : "DefinedSet",
    "speciesId" : 0,
    "diagramIds" : [ 97185 ],
    "parents" : [ 10267220 ],
    "children" : [ 877176, 877209, 877244 ]
  }, {
    "dbId" : 877244,
    "stId" : "R-ALL-877244",
    "displayName" : "Asb [cytosol]",
    "schemaClass" : "SimpleEntity",
    "speciesId" : 0,
    "identifier" : "46661",
    "standardIdentifier" : "chebi:46661",
    "referenceType" : "ReferenceMolecule",
    "parents" : [ 877245 ],
    "children" : [ ]
  }, {
    "dbId" : 10266414,
    "stId" : "R-CFA-1250100",
    "displayName" : "Phospho-p38 MAPK [cytosol]",
    "schemaClass" : "CandidateSet",
    "speciesId" : 49646,
    "diagramIds" : [ 97178 ],
    "parents" : [ ],
    "children" : [ 10258248, 10258254, 10266412, 10256044 ]
  }, {
    "dbId" : 10266408,
    "stId" : "R-CFA-1250102",
    "displayName" : "p38 MAPK [cytosol]",
    "schemaClass" : "CandidateSet",
    "speciesId" : 49646,
    "diagramIds" : [ 97177 ],
    "parents" : [ ],
    "children" : [ 10266400, 10266406, 10266404, 10256042 ]
  }, {
    "dbId" : 622271,
    "stId" : "R-ALL-622271",
    "displayName" : "iE-DAP [cytosol]",
    "schemaClass" : "SimpleEntity",
    "speciesId" : 0,
    "diagramIds" : [ 97099 ],
    "identifier" : "59271",
    "standardIdentifier" : "chebi:59271",
    "referenceType" : "ReferenceMolecule",
    "parents" : [ 10238376 ],
    "children" : [ ]
  }, {
    "dbId" : 10266404,
    "stId" : "R-CFA-171012",
    "displayName" : "MAPK13 [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 49646,
    "identifier" : "A0A8I3NKJ3",
    "standardIdentifier" : "uniprot:A0A8I3NKJ3",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "MAPK13" ],
    "parents" : [ 10266408 ],
    "children" : [ ]
  }, {
    "dbId" : 113592,
    "stId" : "R-ALL-113592",
    "displayName" : "ATP [cytosol]",
    "schemaClass" : "SimpleEntity",
    "speciesId" : 0,
    "diagramIds" : [ 97176, 97164 ],
    "identifier" : "30616",
    "standardIdentifier" : "chebi:30616",
    "referenceType" : "ReferenceMolecule",
    "parents" : [ 10260621 ],
    "children" : [ ]
  }, {
    "dbId" : 29370,
    "stId" : "R-ALL-29370",
    "displayName" : "ADP [cytosol]",
    "schemaClass" : "SimpleEntity",
    "speciesId" : 0,
    "diagramIds" : [ 97179 ],
    "identifier" : "456216",
    "standardIdentifier" : "chebi:456216",
    "referenceType" : "ReferenceMolecule",
    "parents" : [ ],
    "children" : [ ]
  }, {
    "dbId" : 10266406,
    "stId" : "R-CFA-171025",
    "displayName" : "MAPK12 [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 49646,
    "identifier" : "A0A8I3ND88",
    "standardIdentifier" : "uniprot:A0A8I3ND88",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "MAPK12" ],
    "parents" : [ 10266408 ],
    "children" : [ ]
  }, {
    "dbId" : 10266400,
    "stId" : "R-CFA-170989",
    "displayName" : "MAPK11 [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 49646,
    "identifier" : "A0A8I3MVQ2",
    "standardIdentifier" : "uniprot:A0A8I3MVQ2",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "MAPK11" ],
    "parents" : [ 10266408 ],
    "children" : [ ]
  }, {
    "dbId" : 10260768,
    "stId" : "R-CFA-877242",
    "displayName" : "ATP:P2X7 oligomer:PANX1 heptamer [plasma membrane]",
    "schemaClass" : "Complex",
    "speciesId" : 49646,
    "diagramIds" : [ 97142 ],
    "parents" : [ ],
    "children" : [ 10260761, 10260766 ]
  }, {
    "dbId" : 10257953,
    "stId" : "R-CFA-446878",
    "displayName" : "TAK1 complex [cytosol]",
    "schemaClass" : "Complex",
    "speciesId" : 49646,
    "diagramIds" : [ 97183 ],
    "parents" : [ 10258568 ],
    "children" : [ 10257939, 10257943, 10257951 ]
  }, {
    "dbId" : 10232866,
    "stId" : "R-CFA-50845",
    "displayName" : "BIRC3 [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 49646,
    "identifier" : "A1E2V0",
    "standardIdentifier" : "uniprot:A1E2V0",
    "referenceType" : "ReferenceGeneProduct",
    "parents" : [ 10260418 ],
    "children" : [ ]
  }, {
    "dbId" : 10230616,
    "stId" : "R-CFA-57031",
    "displayName" : "CASP8 [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 49646,
    "identifier" : "Q38JA9",
    "standardIdentifier" : "uniprot:Q38JA9",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "CASP8" ],
    "parents" : [ 10260376 ],
    "children" : [ ]
  }, {
    "dbId" : 10267220,
    "stId" : "R-CFA-877226",
    "displayName" : "NLRP3 elicitor small molecules:NLRP3 [cytosol]",
    "schemaClass" : "Complex",
    "speciesId" : 49646,
    "diagramIds" : [ 97186 ],
    "parents" : [ ],
    "children" : [ 10260745, 877245 ]
  }, {
    "dbId" : 10254679,
    "stId" : "R-CFA-419617",
    "displayName" : "HSP90AB1 [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 49646,
    "diagramIds" : [ 97145 ],
    "identifier" : "A0A8I3N9V3",
    "standardIdentifier" : "uniprot:A0A8I3N9V3",
    "referenceType" : "ReferenceGeneProduct",
    "parents" : [ 10260751 ],
    "children" : [ ]
  }, {
    "dbId" : 10260812,
    "stId" : "R-CFA-879197",
    "displayName" : "PSTPIP1 trimer:Pyrin trimer [cytosol]",
    "schemaClass" : "Complex",
    "speciesId" : 49646,
    "diagramIds" : [ 97156 ],
    "parents" : [ ],
    "children" : [ 10260790, 10260810 ]
  }, {
    "dbId" : 1250243,
    "stId" : "R-ALL-1250243",
    "displayName" : "ROS [cytosol]",
    "schemaClass" : "SimpleEntity",
    "speciesId" : 0,
    "diagramIds" : [ 97173 ],
    "identifier" : "26523",
    "standardIdentifier" : "chebi:26523",
    "referenceType" : "ReferenceMolecule",
    "parents" : [ ],
    "children" : [ ]
  }, {
    "dbId" : 10258254,
    "stId" : "R-CFA-171021",
    "displayName" : "phospho-MAPK12 [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 49646,
    "identifier" : "A0A8I3ND88",
    "standardIdentifier" : "uniprot:A0A8I3ND88",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "MAPK12" ],
    "parents" : [ 10266414 ],
    "children" : [ ]
  }, {
    "dbId" : 10258248,
    "stId" : "R-CFA-171009",
    "displayName" : "phospho-MAPK11 [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 49646,
    "identifier" : "A0A8I3MVQ2",
    "standardIdentifier" : "uniprot:A0A8I3MVQ2",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "MAPK11" ],
    "parents" : [ 10266414 ],
    "children" : [ ]
  }, {
    "dbId" : 10260808,
    "stId" : "R-CFA-879220",
    "displayName" : "PSTPIP1 [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 49646,
    "identifier" : "A0A8I3PGK7",
    "standardIdentifier" : "uniprot:A0A8I3PGK7",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "PSTPIP1" ],
    "parents" : [ 10260810 ],
    "children" : [ ]
  }, {
    "dbId" : 10260810,
    "stId" : "R-CFA-879213",
    "displayName" : "PSTPIP1 trimer [cytosol]",
    "schemaClass" : "Complex",
    "speciesId" : 49646,
    "diagramIds" : [ 97155 ],
    "parents" : [ 10260812 ],
    "children" : [ 10260808 ]
  }, {
    "dbId" : 10238278,
    "stId" : "R-CFA-168108",
    "displayName" : "IKBKG [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 49646,
    "diagramIds" : [ 97115 ],
    "identifier" : "A0A8I3S792",
    "standardIdentifier" : "uniprot:A0A8I3S792",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "IKBKG" ],
    "parents" : [ 10260372, 10258566 ],
    "children" : [ ]
  }, {
    "dbId" : 10260800,
    "stId" : "R-CFA-879209",
    "displayName" : "Bcl-2/Bcl-X(L) [mitochondrial outer membrane]",
    "schemaClass" : "DefinedSet",
    "speciesId" : 49646,
    "diagramIds" : [ 97158 ],
    "parents" : [ 10260802 ],
    "children" : [ 10259906, 10234731 ]
  }, {
    "dbId" : 10260802,
    "stId" : "R-CFA-879218",
    "displayName" : "Bcl-2/Bcl-X(L):NLRP1 [mitochondrial outer membrane]",
    "schemaClass" : "Complex",
    "speciesId" : 49646,
    "diagramIds" : [ 97160 ],
    "parents" : [ ],
    "children" : [ 10260800, 10260617 ]
  }, {
    "dbId" : 10230129,
    "stId" : "R-CFA-66000",
    "displayName" : "TXN [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 49646,
    "diagramIds" : [ 97170 ],
    "identifier" : "A0A8I3RXE3",
    "standardIdentifier" : "uniprot:A0A8I3RXE3",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "TXN" ],
    "parents" : [ 10266533 ],
    "children" : [ ]
  }, {
    "dbId" : 10230127,
    "stId" : "R-CFA-73668",
    "displayName" : "TXN [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 49646,
    "diagramIds" : [ 97174 ],
    "identifier" : "A0A8I3RXE3",
    "standardIdentifier" : "uniprot:A0A8I3RXE3",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "TXN" ],
    "parents" : [ ],
    "children" : [ ]
  }, {
    "dbId" : 10258539,
    "stId" : "R-CFA-206255",
    "displayName" : "phospho-MAP2K6 [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 49646,
    "diagramIds" : [ 97180 ],
    "identifier" : "A0A8I3NBF5",
    "standardIdentifier" : "uniprot:A0A8I3NBF5",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "MAP2K6" ],
    "parents" : [ ],
    "children" : [ ]
  }, {
    "dbId" : 10234731,
    "stId" : "R-CFA-50757",
    "displayName" : "BCL2 [mitochondrial outer membrane]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 49646,
    "identifier" : "A0A8I3MLT5",
    "standardIdentifier" : "uniprot:A0A8I3MLT5",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "BCL2" ],
    "parents" : [ 10260800 ],
    "children" : [ ]
  }, {
    "dbId" : 708341,
    "stId" : "R-ALL-708341",
    "displayName" : "MDP [cytosol]",
    "schemaClass" : "SimpleEntity",
    "speciesId" : 0,
    "diagramIds" : [ 97104 ],
    "identifier" : "59414",
    "standardIdentifier" : "chebi:59414",
    "referenceType" : "ReferenceMolecule",
    "parents" : [ 10260619, 10238386 ],
    "children" : [ ]
  } ],
  "edges" : [ {
    "dbId" : 10260380,
    "stId" : "R-CFA-622420",
    "displayName" : "NOD1 induced apoptosis is mediated by RIP2 and CARD8",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "preceding" : [ 10260286 ],
    "inputs" : [ 10260376, 10238376 ],
    "outputs" : [ 10260378 ],
    "efs" : [ ],
    "diagramIds" : [ 97133 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10260764,
    "stId" : "R-CFA-877187",
    "displayName" : "P2X7 mediates loss of intracellular K+",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "following" : [ 10267222 ],
    "inputs" : [ 29804 ],
    "outputs" : [ 74126 ],
    "catalysts" : [ 10260761 ],
    "efs" : [ ],
    "diagramIds" : [ 97136 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10260757,
    "stId" : "R-CFA-874087",
    "displayName" : "SGT1 binds HSP90",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "following" : [ 10260755 ],
    "inputs" : [ 10254679, 10260749 ],
    "outputs" : [ 10260751 ],
    "efs" : [ ],
    "diagramIds" : [ 97143 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10260374,
    "stId" : "R-CFA-622415",
    "displayName" : "RIP2 binds NEMO",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "preceding" : [ 10238398 ],
    "following" : [ 10260485 ],
    "inputs" : [ 10238278, 10238396 ],
    "outputs" : [ 10260372 ],
    "efs" : [ ],
    "diagramIds" : [ 97114 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10267222,
    "stId" : "R-CFA-1306876",
    "displayName" : "NLRP3 activation by small molecules",
    "schemaClass" : "BlackBoxEvent",
    "speciesId" : 0,
    "preceding" : [ 10260755, 10260770, 10260764 ],
    "inputs" : [ 10260753, 877245 ],
    "outputs" : [ 10267220, 10260751 ],
    "efs" : [ ],
    "diagramIds" : [ 97184 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10260816,
    "stId" : "R-CFA-879222",
    "displayName" : "MDP:NLRP1 binds ATP",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "preceding" : [ 10260627 ],
    "following" : [ 10260625 ],
    "inputs" : [ 113592, 10260619 ],
    "outputs" : [ 10260621 ],
    "efs" : [ ],
    "diagramIds" : [ 97163 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10260433,
    "stId" : "R-CFA-706479",
    "displayName" : "TAK1 is activated",
    "schemaClass" : "BlackBoxEvent",
    "speciesId" : 0,
    "preceding" : [ 10260431 ],
    "following" : [ 10260470 ],
    "inputs" : [ 10260429 ],
    "outputs" : [ 10258568 ],
    "efs" : [ ],
    "diagramIds" : [ 97131 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10260625,
    "stId" : "R-CFA-844438",
    "displayName" : "NLRP1 oligomerizes",
    "schemaClass" : "Polymerisation",
    "speciesId" : 0,
    "preceding" : [ 10260816 ],
    "inputs" : [ 10260621 ],
    "outputs" : [ 10260623 ],
    "efs" : [ ],
    "diagramIds" : [ 97166 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10260435,
    "stId" : "R-CFA-708349",
    "displayName" : "Activated NOD2 oligomerizes",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "preceding" : [ 10238400 ],
    "following" : [ 10238398 ],
    "inputs" : [ 10238386 ],
    "outputs" : [ 10238388 ],
    "efs" : [ ],
    "diagramIds" : [ 97108 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10260755,
    "stId" : "R-CFA-873951",
    "displayName" : "SGT1:HSP90 binds inactive NLRP3",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "preceding" : [ 10260757 ],
    "following" : [ 10267222 ],
    "inputs" : [ 10260745, 10260751 ],
    "outputs" : [ 10260753 ],
    "efs" : [ ],
    "diagramIds" : [ 97147 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10260627,
    "stId" : "R-CFA-844447",
    "displayName" : "NLRP1 senses MDP",
    "schemaClass" : "BlackBoxEvent",
    "speciesId" : 0,
    "following" : [ 10260816 ],
    "inputs" : [ 708341, 10260617 ],
    "outputs" : [ 10260619 ],
    "efs" : [ ],
    "diagramIds" : [ 97161 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10260814,
    "stId" : "R-CFA-879221",
    "displayName" : "PSTPIP1 binds Pyrin",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "following" : [ 10260798 ],
    "inputs" : [ 10260790, 10260810 ],
    "outputs" : [ 10260812 ],
    "efs" : [ ],
    "diagramIds" : [ 97154 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10260431,
    "stId" : "R-CFA-688985",
    "displayName" : "K63 polyubiquitinated RIP2 associates with the TAK1 complex",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "preceding" : [ 10260421 ],
    "following" : [ 10260433 ],
    "inputs" : [ 10258566, 10260427 ],
    "outputs" : [ 10260429 ],
    "efs" : [ ],
    "diagramIds" : [ 97128 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10260488,
    "stId" : "R-CFA-741411",
    "displayName" : "CYLD deubiquitinates NEMO",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "preceding" : [ 10260485 ],
    "inputs" : [ 10260482 ],
    "outputs" : [ 10238454, 10260372 ],
    "catalysts" : [ 10232876 ],
    "efs" : [ ],
    "diagramIds" : [ 97121 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10320069,
    "stId" : "R-CFA-9676160",
    "displayName" : "AAMP binds NOD2",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "inputs" : [ 10238384, 10240575 ],
    "outputs" : [ 10320067 ],
    "efs" : [ ],
    "diagramIds" : [ 97187 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10260804,
    "stId" : "R-CFA-879201",
    "displayName" : "Bcl-2 and Bcl-XL bind NLRP1",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "inputs" : [ 10260800, 10260617 ],
    "outputs" : [ 10260802 ],
    "efs" : [ ],
    "diagramIds" : [ 97157 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10260485,
    "stId" : "R-CFA-741386",
    "displayName" : "RIP2 induces K63-linked ubiquitination of NEMO",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "preceding" : [ 10260374 ],
    "following" : [ 10260488 ],
    "inputs" : [ 10238454, 10260372 ],
    "outputs" : [ 10260482 ],
    "catalysts" : [ 10238490 ],
    "efs" : [ ],
    "diagramIds" : [ 97117 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10260421,
    "stId" : "R-CFA-688137",
    "displayName" : "RIP2 is K63 polyubiquitinated",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "preceding" : [ 10238398 ],
    "following" : [ 10260412, 10260431 ],
    "inputs" : [ 10238454, 10260372 ],
    "outputs" : [ 10258566 ],
    "catalysts" : [ 10260418 ],
    "efs" : [ ],
    "diagramIds" : [ 97123 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10238400,
    "stId" : "R-CFA-168412",
    "displayName" : "MDP elicits a NOD2 response",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "following" : [ 10260435 ],
    "inputs" : [ 708341, 10238384 ],
    "outputs" : [ 10238386 ],
    "efs" : [ ],
    "diagramIds" : [ 97102 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10260412,
    "stId" : "R-CFA-688136",
    "displayName" : "TNFAIP3 (A20) deubiquitinates RIP2",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "preceding" : [ 10260421 ],
    "inputs" : [ 10258566 ],
    "outputs" : [ 10238454, 10260372 ],
    "catalysts" : [ 10260409 ],
    "efs" : [ ],
    "diagramIds" : [ 97126 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10260286,
    "stId" : "R-CFA-622310",
    "displayName" : "Activated NOD1 oligomerizes",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "preceding" : [ 10238378 ],
    "following" : [ 10260380, 10238398 ],
    "inputs" : [ 10238376 ],
    "outputs" : [ 10238380 ],
    "efs" : [ ],
    "diagramIds" : [ 97106 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10238398,
    "stId" : "R-CFA-168405",
    "displayName" : "Activated NOD oligomer recruites RIP2 (RICK)",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "preceding" : [ 10260435, 10260286 ],
    "following" : [ 10260374, 10260421 ],
    "inputs" : [ 10238390, 10238394 ],
    "outputs" : [ 10238396 ],
    "efs" : [ ],
    "diagramIds" : [ 97110 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10260798,
    "stId" : "R-CFA-877361",
    "displayName" : "Pyrin binds ASC",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "preceding" : [ 10260814 ],
    "inputs" : [ 10260790, 10260794 ],
    "outputs" : [ 10260796 ],
    "efs" : [ ],
    "diagramIds" : [ 97150 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10260470,
    "stId" : "R-CFA-727819",
    "displayName" : "TAK1 phosphorylates MKK6",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "preceding" : [ 10260433 ],
    "following" : [ 10266417 ],
    "inputs" : [ 10258583, 113592 ],
    "outputs" : [ 29370, 10258539 ],
    "catalysts" : [ 10257953 ],
    "efs" : [ ],
    "diagramIds" : [ 97181 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10266417,
    "stId" : "R-CFA-1247960",
    "displayName" : "Activation of p38 MAPK",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "preceding" : [ 10260470 ],
    "inputs" : [ 113592, 10266408 ],
    "outputs" : [ 29370, 10266414 ],
    "catalysts" : [ 10258539 ],
    "efs" : [ ],
    "diagramIds" : [ 97175 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10266537,
    "stId" : "R-CFA-1250280",
    "displayName" : "ROS oxidize thioredoxin",
    "schemaClass" : "BlackBoxEvent",
    "speciesId" : 0,
    "inputs" : [ 10230129, 1250243 ],
    "outputs" : [ 10230127 ],
    "efs" : [ ],
    "diagramIds" : [ 97172 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10238378,
    "stId" : "R-CFA-168400",
    "displayName" : "iE-DAP elicits a NOD1 response",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "following" : [ 10260286 ],
    "inputs" : [ 10238374, 622271 ],
    "outputs" : [ 10238376 ],
    "efs" : [ ],
    "diagramIds" : [ 97098 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10266535,
    "stId" : "R-CFA-1250264",
    "displayName" : "TXNIP binds reduced thioredoxin",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "inputs" : [ 10266531, 10230129 ],
    "outputs" : [ 10266533 ],
    "efs" : [ ],
    "diagramIds" : [ 97168 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10260770,
    "stId" : "R-CFA-877198",
    "displayName" : "P2X7 mediates membrane pores that include pannexin-1",
    "schemaClass" : "BlackBoxEvent",
    "speciesId" : 0,
    "following" : [ 10267222 ],
    "inputs" : [ 10260761, 10260766 ],
    "outputs" : [ 10260768 ],
    "efs" : [ ],
    "diagramIds" : [ 97140 ],
    "entityFunctionalStatus" : [ ]
  } ],
  "subpathways" : [ {
    "dbId" : 10330513,
    "stId" : "R-CFA-844455",
    "displayName" : "The NLRP1 inflammasome",
    "events" : [ 10260804, 10260816, 10260625, 10260627 ]
  }, {
    "dbId" : 10330515,
    "stId" : "R-CFA-622312",
    "displayName" : "Inflammasomes",
    "events" : [ 10260764, 10260814, 10260798, 10266537, 10260757, 10267222, 10266535, 10260770, 10260755, 10260804, 10260816, 10260625, 10260627 ]
  }, {
    "dbId" : 10330521,
    "stId" : "R-CFA-844456",
    "displayName" : "The NLRP3 inflammasome",
    "events" : [ 10260764, 10260814, 10260798, 10266537, 10260757, 10267222, 10266535, 10260770, 10260755 ]
  }, {
    "dbId" : 10329429,
    "stId" : "R-CFA-168638",
    "displayName" : "NOD1/2 Signaling Pathway",
    "events" : [ 10260412, 10260380, 10260286, 10238398, 10260374, 10260470, 10260433, 10266417, 10260435, 10260431, 10260488, 10238378, 10320069, 10260485, 10260421, 10238400 ]
  } ]
}