{
  "dbId" : 10329427,
  "stId" : "R-CFA-446652",
  "speciesName" : "Canis familiaris",
  "nodes" : [ {
    "dbId" : 10242455,
    "stId" : "R-CFA-168114",
    "displayName" : "IKBKB [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 49646,
    "identifier" : "A0A8I3N4F2",
    "standardIdentifier" : "uniprot:A0A8I3N4F2",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "IKBKB" ],
    "parents" : [ 10245377 ],
    "children" : [ ]
  }, {
    "dbId" : 10258583,
    "stId" : "R-CFA-167998",
    "displayName" : "MAP2K6 [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 49646,
    "diagramIds" : [ 55235 ],
    "identifier" : "A0A8I3NBF5",
    "standardIdentifier" : "uniprot:A0A8I3NBF5",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "MAP2K6" ],
    "parents" : [ ],
    "children" : [ ]
  }, {
    "dbId" : 10258317,
    "stId" : "R-CFA-448446",
    "displayName" : "IL18 [extracellular region]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 49646,
    "diagramIds" : [ 55299 ],
    "identifier" : "A0A8I3RRK2",
    "standardIdentifier" : "uniprot:A0A8I3RRK2",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "IL18" ],
    "parents" : [ 10306375 ],
    "children" : [ ]
  }, {
    "dbId" : 10316175,
    "stId" : "R-CFA-9009901",
    "displayName" : "IL37(?-218):p-S423,S425-SMAD3 [cytosol]",
    "schemaClass" : "Complex",
    "speciesId" : 49646,
    "diagramIds" : [ 55278 ],
    "parents" : [ ],
    "children" : [ 10238983, 10316134 ]
  }, {
    "dbId" : 10242441,
    "stId" : "R-CFA-193937",
    "displayName" : "SQSTM1 [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 49646,
    "identifier" : "A0A8I3N2A1",
    "standardIdentifier" : "uniprot:A0A8I3N2A1",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "SQSTM1" ],
    "parents" : [ 10259811 ],
    "children" : [ ]
  }, {
    "dbId" : 10258816,
    "stId" : "R-CFA-451425",
    "displayName" : "hp-IRAK1:p-Pellino, IRAK4:p-Pellino [cytosol]",
    "schemaClass" : "DefinedSet",
    "speciesId" : 49646,
    "diagramIds" : [ 55225 ],
    "parents" : [ ],
    "children" : [ 10258814, 10258812 ]
  }, {
    "dbId" : 9681804,
    "stId" : "R-ALL-9681804",
    "displayName" : "IL1R1 inhibitors [extracellular region]",
    "schemaClass" : "DefinedSet",
    "speciesId" : 0,
    "diagramIds" : [ 55324 ],
    "parents" : [ 10257624 ],
    "children" : [ 9681784, 9681764 ]
  }, {
    "dbId" : 10238140,
    "stId" : "R-CFA-166366",
    "displayName" : "TRAF6 [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 49646,
    "diagramIds" : [ 55197 ],
    "identifier" : "A0A8I3P2V4",
    "standardIdentifier" : "uniprot:A0A8I3P2V4",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "TRAF6" ],
    "parents" : [ 10259813, 10257965, 10257963, 10257933 ],
    "children" : [ ]
  }, {
    "dbId" : 10257886,
    "stId" : "R-CFA-446885",
    "displayName" : "TOLLIP [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 49646,
    "diagramIds" : [ 55176 ],
    "identifier" : "A0A8I3RUU8",
    "standardIdentifier" : "uniprot:A0A8I3RUU8",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "TOLLIP" ],
    "parents" : [ 10257888, 10257895 ],
    "children" : [ ]
  }, {
    "dbId" : 10257631,
    "stId" : "R-CFA-197598",
    "displayName" : "IL1R2 [plasma membrane]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 49646,
    "diagramIds" : [ 55164 ],
    "identifier" : "A0A8I3NJ31",
    "standardIdentifier" : "uniprot:A0A8I3NJ31",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "IL1R2" ],
    "parents" : [ 10257699 ],
    "children" : [ ]
  }, {
    "dbId" : 10257624,
    "stId" : "R-CFA-9681780",
    "displayName" : "IL1R1:IL1R1 inhibitors [plasma membrane]",
    "schemaClass" : "Complex",
    "speciesId" : 49646,
    "diagramIds" : [ 55162 ],
    "parents" : [ ],
    "children" : [ 9681804, 10257600 ]
  }, {
    "dbId" : 10257880,
    "stId" : "R-CFA-450120",
    "displayName" : "IL1R1:IL1:IL1RAP:MYD88 dimer [plasma membrane]",
    "schemaClass" : "Complex",
    "speciesId" : 49646,
    "diagramIds" : [ 55171 ],
    "parents" : [ 10257882 ],
    "children" : [ 10242513, 10257620 ]
  }, {
    "dbId" : 10238426,
    "stId" : "R-CFA-939176",
    "displayName" : "UBA52 [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 49646,
    "identifier" : "P63050",
    "standardIdentifier" : "uniprot:P63050",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "UBA52" ],
    "parents" : [ 10238452 ],
    "children" : [ ]
  }, {
    "dbId" : 10257882,
    "stId" : "R-CFA-446637",
    "displayName" : "IL1R1:IL1:IL1RAP:IRAK4:MYD88 dimer [plasma membrane]",
    "schemaClass" : "Complex",
    "speciesId" : 49646,
    "diagramIds" : [ 55174 ],
    "parents" : [ 10257888 ],
    "children" : [ 10257878, 10257880 ]
  }, {
    "dbId" : 10257620,
    "stId" : "R-CFA-445758",
    "displayName" : "IL1R1:IL1:IL1RAP [plasma membrane]",
    "schemaClass" : "Complex",
    "speciesId" : 49646,
    "diagramIds" : [ 55168 ],
    "parents" : [ 10257880, 10257895 ],
    "children" : [ 10257618, 10257614 ]
  }, {
    "dbId" : 10243285,
    "stId" : "R-CFA-168104",
    "displayName" : "CHUK [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 49646,
    "identifier" : "A0A8I3P499",
    "standardIdentifier" : "uniprot:A0A8I3P499",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "CHUK" ],
    "parents" : [ 10245377 ],
    "children" : [ ]
  }, {
    "dbId" : 10257878,
    "stId" : "R-CFA-166081",
    "displayName" : "IRAK4 [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 49646,
    "diagramIds" : [ 55173 ],
    "identifier" : "A0A8I3Q059",
    "standardIdentifier" : "uniprot:A0A8I3Q059",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "IRAK4" ],
    "parents" : [ 10258777, 10257882, 10258814, 10258795 ],
    "children" : [ ]
  }, {
    "dbId" : 10238417,
    "stId" : "R-CFA-939224",
    "displayName" : "RPS27A [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 49646,
    "identifier" : "A0A8I3NFB9",
    "standardIdentifier" : "uniprot:A0A8I3NFB9",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "RPS27A" ],
    "parents" : [ 10238452 ],
    "children" : [ ]
  }, {
    "dbId" : 10242513,
    "stId" : "R-CFA-193932",
    "displayName" : "MYD88 dimer [cytosol]",
    "schemaClass" : "Complex",
    "speciesId" : 49646,
    "diagramIds" : [ 55170 ],
    "parents" : [ 10257880, 10257895 ],
    "children" : [ 10242511 ]
  }, {
    "dbId" : 10257618,
    "stId" : "R-CFA-445745",
    "displayName" : "IL1RAP [plasma membrane]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 49646,
    "diagramIds" : [ 55310, 55167 ],
    "identifier" : "A0A8I3PN81",
    "standardIdentifier" : "uniprot:A0A8I3PN81",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "IL1RAP" ],
    "parents" : [ 10306323, 10257620 ],
    "children" : [ ]
  }, {
    "dbId" : 10257612,
    "stId" : "R-CFA-445744",
    "displayName" : "IL1B,Myr82K-Myr83K-IL1A [extracellular region]",
    "schemaClass" : "DefinedSet",
    "speciesId" : 49646,
    "diagramIds" : [ 55159 ],
    "parents" : [ 10257699, 10257614 ],
    "children" : [ 10257606, 10257610 ]
  }, {
    "dbId" : 10257614,
    "stId" : "R-CFA-445755",
    "displayName" : "IL1B,Myr82K-Myr83K-IL1A:IL1R1 [plasma membrane]",
    "schemaClass" : "Complex",
    "speciesId" : 49646,
    "diagramIds" : [ 55161 ],
    "parents" : [ 10257620 ],
    "children" : [ 10257600, 10257612 ]
  }, {
    "dbId" : 10238414,
    "stId" : "R-CFA-939169",
    "displayName" : "Ub-63-UBA52(1-76) [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 49646,
    "identifier" : "A0A8I3PFZ3",
    "standardIdentifier" : "uniprot:A0A8I3PFZ3",
    "referenceType" : "ReferenceGeneProduct",
    "parents" : [ 10238452 ],
    "children" : [ ]
  }, {
    "dbId" : 10242511,
    "stId" : "R-CFA-166059",
    "displayName" : "MYD88 [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 49646,
    "identifier" : "A0A8I3Q209",
    "standardIdentifier" : "uniprot:A0A8I3Q209",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "MYD88" ],
    "parents" : [ 10242513 ],
    "children" : [ ]
  }, {
    "dbId" : 10238921,
    "stId" : "R-CFA-170855",
    "displayName" : "Madh3 [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 49646,
    "diagramIds" : [ 55275 ],
    "identifier" : "D2YYC0",
    "standardIdentifier" : "uniprot:D2YYC0",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "Madh3" ],
    "parents" : [ 10316136 ],
    "children" : [ ]
  }, {
    "dbId" : 10257610,
    "stId" : "R-CFA-445748",
    "displayName" : "IL1B [extracellular region]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 49646,
    "identifier" : "A0A8I3NVB6",
    "standardIdentifier" : "uniprot:A0A8I3NVB6",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "IL1B" ],
    "parents" : [ 10257612 ],
    "children" : [ ]
  }, {
    "dbId" : 10238411,
    "stId" : "R-CFA-939248",
    "displayName" : "Ub-63-RPS27A(1-76) [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 49646,
    "identifier" : "A0A8I3NUE4",
    "standardIdentifier" : "uniprot:A0A8I3NUE4",
    "referenceType" : "ReferenceGeneProduct",
    "parents" : [ 10238452 ],
    "children" : [ ]
  }, {
    "dbId" : 10316484,
    "stId" : "R-CFA-9008602",
    "displayName" : "IL36G [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 49646,
    "diagramIds" : [ 55322 ],
    "identifier" : "A0A8I3NFJ0",
    "standardIdentifier" : "uniprot:A0A8I3NFJ0",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "IL36G" ],
    "parents" : [ 10316486 ],
    "children" : [ ]
  }, {
    "dbId" : 10257606,
    "stId" : "R-CFA-445746",
    "displayName" : "IL1A [extracellular region]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 49646,
    "identifier" : "A0A8I3NHA9",
    "standardIdentifier" : "uniprot:A0A8I3NHA9",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "IL1A" ],
    "parents" : [ 10257612 ],
    "children" : [ ]
  }, {
    "dbId" : 10316486,
    "stId" : "R-CFA-9012554",
    "displayName" : "IL37(1-?):IL37(?-218):CASP1(120-197):CASP1(317-404) [cytosol]",
    "schemaClass" : "Complex",
    "speciesId" : 49646,
    "diagramIds" : [ 55320 ],
    "parents" : [ ],
    "children" : [ 10258163, 10316134, 10316484 ]
  }, {
    "dbId" : 10257600,
    "stId" : "R-CFA-197595",
    "displayName" : "IL1R1 [plasma membrane]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 49646,
    "diagramIds" : [ 55160 ],
    "identifier" : "A0A8I3RY59",
    "standardIdentifier" : "uniprot:A0A8I3RY59",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "IL1R1" ],
    "parents" : [ 10257624, 10257614 ],
    "children" : [ ]
  }, {
    "dbId" : 10316480,
    "stId" : "R-CFA-9012553",
    "displayName" : "IL37:2x(CASP1(120-197):CASP1(317-404)) [cytosol]",
    "schemaClass" : "Complex",
    "speciesId" : 49646,
    "diagramIds" : [ 55318 ],
    "parents" : [ ],
    "children" : [ 10258180, 10316140 ]
  }, {
    "dbId" : 10257918,
    "stId" : "R-CFA-446687",
    "displayName" : "phospho-IRAK1 [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 49646,
    "identifier" : "A0A8I3PV99",
    "standardIdentifier" : "uniprot:A0A8I3PV99",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "IRAK1" ],
    "parents" : [ 10257920 ],
    "children" : [ ]
  }, {
    "dbId" : 10315513,
    "stId" : "R-CFA-8983130",
    "displayName" : "phospho-STAT3 [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 49646,
    "diagramIds" : [ 55262 ],
    "identifier" : "A0A8I3RV66",
    "standardIdentifier" : "uniprot:A0A8I3RV66",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "STAT3" ],
    "parents" : [ ],
    "children" : [ ]
  }, {
    "dbId" : 10257912,
    "stId" : "R-CFA-446693",
    "displayName" : "IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP:IRAK1 [plasma membrane]",
    "schemaClass" : "Complex",
    "speciesId" : 49646,
    "diagramIds" : [ 55184 ],
    "parents" : [ ],
    "children" : [ 10257895, 10257910 ]
  }, {
    "dbId" : 10258937,
    "stId" : "R-CFA-8948061",
    "displayName" : "K63polyUb-hp-IRAK1:p-Pellino-1,2,(3) [cytosol]",
    "schemaClass" : "Complex",
    "speciesId" : 49646,
    "parents" : [ 10258939 ],
    "children" : [ 10258935, 10258810 ]
  }, {
    "dbId" : 10258939,
    "stId" : "R-CFA-8948058",
    "displayName" : "K63polyUb-hp-IRAK1:p-Pellino-1,2,(3):UBE2N:UBE2V1 [cytosol]",
    "schemaClass" : "Complex",
    "speciesId" : 49646,
    "diagramIds" : [ 55228 ],
    "parents" : [ ],
    "children" : [ 10258937, 10238488 ]
  }, {
    "dbId" : 10238452,
    "stId" : "R-CFA-450143",
    "displayName" : "K63-Ub [cytosol]",
    "schemaClass" : "DefinedSet",
    "speciesId" : 49646,
    "parents" : [ 10238454 ],
    "children" : [ 10238417, 10238411, 10238426, 10238414 ]
  }, {
    "dbId" : 10238454,
    "stId" : "R-CFA-450152",
    "displayName" : "K63polyUb [cytosol]",
    "schemaClass" : "Polymer",
    "speciesId" : 49646,
    "parents" : [ 10257967 ],
    "children" : [ 10238452 ]
  }, {
    "dbId" : 10257910,
    "stId" : "R-CFA-446639",
    "displayName" : "IRAK1 [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 49646,
    "diagramIds" : [ 55183 ],
    "identifier" : "A0A8I3PV99",
    "standardIdentifier" : "uniprot:A0A8I3PV99",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "IRAK1" ],
    "parents" : [ 10257912 ],
    "children" : [ ]
  }, {
    "dbId" : 10258935,
    "stId" : "R-CFA-451565",
    "displayName" : "phospho-IRAK1 [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 49646,
    "diagramIds" : [ 55231 ],
    "identifier" : "A0A8I3PV99",
    "standardIdentifier" : "uniprot:A0A8I3PV99",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "IRAK1" ],
    "parents" : [ 10258937, 10258944 ],
    "children" : [ ]
  }, {
    "dbId" : 10258161,
    "stId" : "R-CFA-448686",
    "displayName" : "CASP4 [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 49646,
    "identifier" : "A0A8I3MG12",
    "standardIdentifier" : "uniprot:A0A8I3MG12",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "CASP4" ],
    "parents" : [ 10258163 ],
    "children" : [ ]
  }, {
    "dbId" : 10257906,
    "stId" : "R-CFA-446636",
    "displayName" : "phospho-IRAK2 [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 49646,
    "diagramIds" : [ 55195 ],
    "identifier" : "A0A8I3N5F6",
    "standardIdentifier" : "uniprot:A0A8I3N5F6",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "IRAK2" ],
    "parents" : [ ],
    "children" : [ ]
  }, {
    "dbId" : 10258163,
    "stId" : "R-CFA-448695",
    "displayName" : "CASP1(120-197):CASP1(317-404) [cytosol]",
    "schemaClass" : "Complex",
    "speciesId" : 49646,
    "parents" : [ 10316486, 10258180 ],
    "children" : [ 10258161, 10258159 ]
  }, {
    "dbId" : 10258931,
    "stId" : "R-CFA-8948064",
    "displayName" : "hp-IRAK1: p-Pellino-1,2,(3):UBE2N:UBE2V1:K63polyUb [cytosol]",
    "schemaClass" : "Complex",
    "speciesId" : 49646,
    "diagramIds" : [ 55227 ],
    "parents" : [ 10313068 ],
    "children" : [ 10257967, 10258812 ]
  }, {
    "dbId" : 10258159,
    "stId" : "R-CFA-448704",
    "displayName" : "CASP4 [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 49646,
    "identifier" : "A0A8I3MG12",
    "standardIdentifier" : "uniprot:A0A8I3MG12",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "CASP4" ],
    "parents" : [ 10258163 ],
    "children" : [ ]
  }, {
    "dbId" : 10257903,
    "stId" : "R-CFA-772534",
    "displayName" : "IRAK2 [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 49646,
    "diagramIds" : [ 55194 ],
    "identifier" : "A0A8I3N5F6",
    "standardIdentifier" : "uniprot:A0A8I3N5F6",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "IRAK2" ],
    "parents" : [ ],
    "children" : [ ]
  }, {
    "dbId" : 10245353,
    "stId" : "R-CFA-2685681",
    "displayName" : "TRAF6 [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 49646,
    "identifier" : "A0A8I3P2V4",
    "standardIdentifier" : "uniprot:A0A8I3P2V4",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "TRAF6" ],
    "parents" : [ 10257957, 10257971, 10257955 ],
    "children" : [ ]
  }, {
    "dbId" : 10257893,
    "stId" : "R-CFA-446649",
    "displayName" : "phospho-IRAK4 [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 49646,
    "diagramIds" : [ 55204 ],
    "identifier" : "A0A8I3Q059",
    "standardIdentifier" : "uniprot:A0A8I3Q059",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "IRAK4" ],
    "parents" : [ 10257895 ],
    "children" : [ ]
  }, {
    "dbId" : 10257895,
    "stId" : "R-CFA-446643",
    "displayName" : "IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP [plasma membrane]",
    "schemaClass" : "Complex",
    "speciesId" : 49646,
    "diagramIds" : [ 55181 ],
    "parents" : [ 10257920, 10257912, 10257928 ],
    "children" : [ 10242513, 10257893, 10257620, 10257886 ]
  }, {
    "dbId" : 10257888,
    "stId" : "R-CFA-446888",
    "displayName" : "IL1R1:IL1:IL1RAP:IRAK4:MYD88 dimer:TOLLIP [plasma membrane]",
    "schemaClass" : "Complex",
    "speciesId" : 49646,
    "diagramIds" : [ 55177 ],
    "parents" : [ ],
    "children" : [ 10257882, 10257886 ]
  }, {
    "dbId" : 10306333,
    "stId" : "R-CFA-8981684",
    "displayName" : "IL36RN, IL1F10 [extracellular region]",
    "schemaClass" : "DefinedSet",
    "speciesId" : 49646,
    "diagramIds" : [ 55314 ],
    "parents" : [ 10306335 ],
    "children" : [ 10306327, 10306331 ]
  }, {
    "dbId" : 10257949,
    "stId" : "R-CFA-450264",
    "displayName" : "TAB3 [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 49646,
    "identifier" : "A0A8I3NMB6",
    "standardIdentifier" : "uniprot:A0A8I3NMB6",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "TAB3" ],
    "parents" : [ 10257951 ],
    "children" : [ ]
  }, {
    "dbId" : 10306335,
    "stId" : "R-CFA-8940997",
    "displayName" : "IL36RN,IL1F10:IL1RL2 [plasma membrane]",
    "schemaClass" : "Complex",
    "speciesId" : 49646,
    "diagramIds" : [ 55312 ],
    "parents" : [ ],
    "children" : [ 10306319, 10306333 ]
  }, {
    "dbId" : 10257951,
    "stId" : "R-CFA-446874",
    "displayName" : "TAB2,TAB3 [cytosol]",
    "schemaClass" : "DefinedSet",
    "speciesId" : 49646,
    "parents" : [ 10257953 ],
    "children" : [ 10257945, 10257949 ]
  }, {
    "dbId" : 10238488,
    "stId" : "R-CFA-202463",
    "displayName" : "UBE2N:UBE2V1 [cytosol]",
    "schemaClass" : "Complex",
    "speciesId" : 49646,
    "diagramIds" : [ 55241 ],
    "parents" : [ 10258939, 10257971 ],
    "children" : [ 10238482, 10238486 ]
  }, {
    "dbId" : 10257945,
    "stId" : "R-CFA-168117",
    "displayName" : "TAB2 [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 49646,
    "identifier" : "A0A8I3P4Z1",
    "standardIdentifier" : "uniprot:A0A8I3P4Z1",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "TAB2" ],
    "parents" : [ 10257951 ],
    "children" : [ ]
  }, {
    "dbId" : 10306331,
    "stId" : "R-CFA-8863045",
    "displayName" : "IL1F10 [extracellular region]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 49646,
    "diagramIds" : [ 55281 ],
    "identifier" : "A0A8I3NLK5",
    "standardIdentifier" : "uniprot:A0A8I3NLK5",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "IL1F10" ],
    "parents" : [ 10306333, 10316059, 10316083 ],
    "children" : [ ]
  }, {
    "dbId" : 10316059,
    "stId" : "R-CFA-9007902",
    "displayName" : "IL1F10:IL1RL2 [plasma membrane]",
    "schemaClass" : "Complex",
    "speciesId" : 49646,
    "diagramIds" : [ 55282 ],
    "parents" : [ ],
    "children" : [ 10306331, 10306319 ]
  }, {
    "dbId" : 10316053,
    "stId" : "R-CFA-9007899",
    "displayName" : "IL1F10 [extracellular region]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 49646,
    "diagramIds" : [ 55285 ],
    "identifier" : "A0A8I3NLK5",
    "standardIdentifier" : "uniprot:A0A8I3NLK5",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "IL1F10" ],
    "parents" : [ ],
    "children" : [ ]
  }, {
    "dbId" : 10316055,
    "stId" : "R-CFA-9007903",
    "displayName" : "IL1F10 [extracellular region]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 49646,
    "diagramIds" : [ 55284 ],
    "identifier" : "A0A8I3NLK5",
    "standardIdentifier" : "uniprot:A0A8I3NLK5",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "IL1F10" ],
    "parents" : [ 10316075 ],
    "children" : [ ]
  }, {
    "dbId" : 10238486,
    "stId" : "R-CFA-205753",
    "displayName" : "UBE2V1 [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 49646,
    "identifier" : "E2R2I5",
    "standardIdentifier" : "uniprot:E2R2I5",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "UBE2V1" ],
    "parents" : [ 10257967, 10238488 ],
    "children" : [ ]
  }, {
    "dbId" : 10306327,
    "stId" : "R-CFA-8940995",
    "displayName" : "IL36RN [extracellular region]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 49646,
    "diagramIds" : [ 55308 ],
    "identifier" : "A0A8I3NL74",
    "standardIdentifier" : "uniprot:A0A8I3NL74",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "IL36RN" ],
    "parents" : [ 10306333 ],
    "children" : [ ]
  }, {
    "dbId" : 10257943,
    "stId" : "R-CFA-167923",
    "displayName" : "TAB1 [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 49646,
    "identifier" : "A0A8I3PLL0",
    "standardIdentifier" : "uniprot:A0A8I3PLL0",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "TAB1" ],
    "parents" : [ 10257953 ],
    "children" : [ ]
  }, {
    "dbId" : 10238480,
    "stId" : "R-CFA-206072-2",
    "displayName" : "UBE2N [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 49646,
    "identifier" : "A0A8I3PGB2",
    "standardIdentifier" : "uniprot:A0A8I3PGB2",
    "referenceType" : "ReferenceGeneProduct",
    "parents" : [ 10238482 ],
    "children" : [ ]
  }, {
    "dbId" : 10306321,
    "stId" : "R-CFA-8848321",
    "displayName" : "IL36:IL1RL2 [plasma membrane]",
    "schemaClass" : "Complex",
    "speciesId" : 49646,
    "diagramIds" : [ 55307 ],
    "parents" : [ 10306323 ],
    "children" : [ 10306315, 10306319 ]
  }, {
    "dbId" : 10262545,
    "stId" : "R-CFA-166267",
    "displayName" : "TBK1 [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 49646,
    "diagramIds" : [ 55266 ],
    "identifier" : "A0A8I3NK16",
    "standardIdentifier" : "uniprot:A0A8I3NK16",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "TBK1" ],
    "parents" : [ ],
    "children" : [ ]
  }, {
    "dbId" : 10238482,
    "stId" : "R-CFA-206072-3",
    "displayName" : "Homologues of UBE2N [cytosol]",
    "schemaClass" : "DefinedSet",
    "speciesId" : 49646,
    "parents" : [ 10257967, 10238488 ],
    "children" : [ 10238480, 10238478 ]
  }, {
    "dbId" : 10258194,
    "stId" : "R-CFA-449046",
    "displayName" : "IL1B [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 49646,
    "diagramIds" : [ 55202 ],
    "identifier" : "A0A8I3NVB6",
    "standardIdentifier" : "uniprot:A0A8I3NVB6",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "IL1B" ],
    "parents" : [ ],
    "children" : [ ]
  }, {
    "dbId" : 10306323,
    "stId" : "R-CFA-8848318",
    "displayName" : "IL36:IL1RL2:IL1RAP-1 [plasma membrane]",
    "schemaClass" : "Complex",
    "speciesId" : 49646,
    "diagramIds" : [ 55311 ],
    "parents" : [ ],
    "children" : [ 10257618, 10306321 ]
  }, {
    "dbId" : 10257939,
    "stId" : "R-CFA-168156",
    "displayName" : "MAP3K7 [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 49646,
    "identifier" : "A0A8I3N7L6",
    "standardIdentifier" : "uniprot:A0A8I3N7L6",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "MAP3K7" ],
    "parents" : [ 10257953 ],
    "children" : [ ]
  }, {
    "dbId" : 10257933,
    "stId" : "R-CFA-446864",
    "displayName" : "IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP:p-2S,S376,T,T209,T378-IRAK1:TRAF6 [plasma membrane]",
    "schemaClass" : "Complex",
    "speciesId" : 49646,
    "diagramIds" : [ 55198 ],
    "parents" : [ ],
    "children" : [ 10257928, 10238140 ]
  }, {
    "dbId" : 10306319,
    "stId" : "R-CFA-197599",
    "displayName" : "IL1RL2 [plasma membrane]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 49646,
    "diagramIds" : [ 55280 ],
    "identifier" : "A0A8I3NGM0",
    "standardIdentifier" : "uniprot:A0A8I3NGM0",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "IL1RL2" ],
    "parents" : [ 10306321, 10306335, 10316059 ],
    "children" : [ ]
  }, {
    "dbId" : 10238478,
    "stId" : "R-CFA-206072",
    "displayName" : "UBE2N [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 49646,
    "identifier" : "A0A8I3P6I7",
    "standardIdentifier" : "uniprot:A0A8I3P6I7",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "UBE2N" ],
    "parents" : [ 10238482 ],
    "children" : [ ]
  }, {
    "dbId" : 10257928,
    "stId" : "R-CFA-446696",
    "displayName" : "IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP:p-2S,S376,T,T209,T378-IRAK1 [plasma membrane]",
    "schemaClass" : "Complex",
    "speciesId" : 49646,
    "diagramIds" : [ 55192 ],
    "parents" : [ 10257933 ],
    "children" : [ 10257895, 10257926 ]
  }, {
    "dbId" : 10306315,
    "stId" : "R-CFA-8848327",
    "displayName" : "IL36B [extracellular region]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 49646,
    "diagramIds" : [ 55306 ],
    "identifier" : "A0A8I3NGJ4",
    "standardIdentifier" : "uniprot:A0A8I3NGJ4",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "IL36B" ],
    "parents" : [ 10306321 ],
    "children" : [ ]
  }, {
    "dbId" : 10258180,
    "stId" : "R-CFA-448691",
    "displayName" : "Caspase-1 tetramer [cytosol]",
    "schemaClass" : "Complex",
    "speciesId" : 49646,
    "diagramIds" : [ 55317 ],
    "parents" : [ 10316480 ],
    "children" : [ 10258163 ]
  }, {
    "dbId" : 10257926,
    "stId" : "R-CFA-446682",
    "displayName" : "phospho-IRAK1 [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 49646,
    "identifier" : "A0A8I3PV99",
    "standardIdentifier" : "uniprot:A0A8I3PV99",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "IRAK1" ],
    "parents" : [ 10258777, 10258793, 10258812, 10257963, 10257928, 10257955 ],
    "children" : [ ]
  }, {
    "dbId" : 10238983,
    "stId" : "R-CFA-171184",
    "displayName" : "phospho-Madh3 [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 49646,
    "diagramIds" : [ 55297 ],
    "identifier" : "D2YYC0",
    "standardIdentifier" : "uniprot:D2YYC0",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "Madh3" ],
    "parents" : [ 10316175 ],
    "children" : [ ]
  }, {
    "dbId" : 10257920,
    "stId" : "R-CFA-446689",
    "displayName" : "IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP:p-S376,T378-IRAK1 [plasma membrane]",
    "schemaClass" : "Complex",
    "speciesId" : 49646,
    "diagramIds" : [ 55187 ],
    "parents" : [ ],
    "children" : [ 10257895, 10257918 ]
  }, {
    "dbId" : 10258944,
    "stId" : "R-CFA-451560",
    "displayName" : "Poly-K6-Ub-hp-IRAK1:CHUK:IKBKB:IKBKG [cytosol]",
    "schemaClass" : "Complex",
    "speciesId" : 49646,
    "diagramIds" : [ 55232 ],
    "parents" : [ ],
    "children" : [ 10245377, 10258935 ]
  }, {
    "dbId" : 10245377,
    "stId" : "R-CFA-168113",
    "displayName" : "CHUK:IKBKB:IKBKG [cytosol]",
    "schemaClass" : "Complex",
    "speciesId" : 49646,
    "diagramIds" : [ 55230 ],
    "parents" : [ 10258944 ],
    "children" : [ 10242455, 10238278, 10243285 ]
  }, {
    "dbId" : 10238268,
    "stId" : "R-CFA-177677",
    "displayName" : "phospho-NFKBIA [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 49646,
    "diagramIds" : [ 55250 ],
    "identifier" : "A0A8I3MKL4",
    "standardIdentifier" : "uniprot:A0A8I3MKL4",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "NFKBIA" ],
    "parents" : [ ],
    "children" : [ ]
  }, {
    "dbId" : 10257978,
    "stId" : "R-CFA-166103",
    "displayName" : "IRAK3 [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 49646,
    "diagramIds" : [ 55206 ],
    "identifier" : "A0A8I3NPR4",
    "standardIdentifier" : "uniprot:A0A8I3NPR4",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "IRAK3" ],
    "parents" : [ ],
    "children" : [ ]
  }, {
    "dbId" : 10306353,
    "stId" : "R-CFA-8848514",
    "displayName" : "IL18R1:IL37,IL37(?-218) [plasma membrane]",
    "schemaClass" : "Complex",
    "speciesId" : 49646,
    "diagramIds" : [ 55255 ],
    "parents" : [ 10316124 ],
    "children" : [ 10306345, 10306349 ]
  }, {
    "dbId" : 10238256,
    "stId" : "R-CFA-168151",
    "displayName" : "NFKBIA [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 49646,
    "diagramIds" : [ 55248 ],
    "identifier" : "A0A8I3MKL4",
    "standardIdentifier" : "uniprot:A0A8I3MKL4",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "NFKBIA" ],
    "parents" : [ ],
    "children" : [ ]
  }, {
    "dbId" : 10257969,
    "stId" : "R-CFA-8948014",
    "displayName" : "hp-IRAK1:3xTRAF6:3xUBE2N:UBE2V1:K63polyUb [cytosol]",
    "schemaClass" : "Complex",
    "speciesId" : 49646,
    "diagramIds" : [ 55210 ],
    "parents" : [ ],
    "children" : [ 10257967, 10257965 ]
  }, {
    "dbId" : 10316083,
    "stId" : "R-CFA-9007912",
    "displayName" : "IL1F10:IL1RAPL1 [plasma membrane]",
    "schemaClass" : "Complex",
    "speciesId" : 49646,
    "diagramIds" : [ 55288 ],
    "parents" : [ ],
    "children" : [ 10306331, 10316073 ]
  }, {
    "dbId" : 10257971,
    "stId" : "R-CFA-450144",
    "displayName" : "hp-IRAK1:3xK63-polyUb-TRAF6:3xUBE2N:UBE2V1 [cytosol]",
    "schemaClass" : "Complex",
    "speciesId" : 49646,
    "diagramIds" : [ 55211 ],
    "parents" : [ 10258513 ],
    "children" : [ 10257955, 10245353, 10238488 ]
  }, {
    "dbId" : 10306349,
    "stId" : "R-CFA-8848334",
    "displayName" : "IL36G [extracellular region]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 49646,
    "diagramIds" : [ 55253 ],
    "identifier" : "A0A8I3NFJ0",
    "standardIdentifier" : "uniprot:A0A8I3NFJ0",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "IL36G" ],
    "parents" : [ 10306353 ],
    "children" : [ ]
  }, {
    "dbId" : 10257965,
    "stId" : "R-CFA-450159",
    "displayName" : "hp-IRAK1:3xTRAF6 [cytosol]",
    "schemaClass" : "Complex",
    "speciesId" : 49646,
    "diagramIds" : [ 55208 ],
    "parents" : [ 10257969 ],
    "children" : [ 10257963, 10238140 ]
  }, {
    "dbId" : 10235183,
    "stId" : "R-CFA-168141",
    "displayName" : "MAPK8 [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 49646,
    "diagramIds" : [ 55292 ],
    "identifier" : "A0A8I3NY64",
    "standardIdentifier" : "uniprot:A0A8I3NY64",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "MAPK8" ],
    "parents" : [ ],
    "children" : [ ]
  }, {
    "dbId" : 10257967,
    "stId" : "R-CFA-8948017",
    "displayName" : "UBE2N:UBE2V1:K63polyUb [cytosol]",
    "schemaClass" : "Complex",
    "speciesId" : 49646,
    "diagramIds" : [ 55239 ],
    "parents" : [ 10313066, 10258931, 10257969 ],
    "children" : [ 10238482, 10238486, 10238454 ]
  }, {
    "dbId" : 10316073,
    "stId" : "R-CFA-6797781",
    "displayName" : "IL1RAPL1 [plasma membrane]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 49646,
    "diagramIds" : [ 55287 ],
    "identifier" : "A0A8I3QQB4",
    "standardIdentifier" : "uniprot:A0A8I3QQB4",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "IL1RAPL1" ],
    "parents" : [ 10316083, 10316075 ],
    "children" : [ ]
  }, {
    "dbId" : 10306345,
    "stId" : "R-CFA-197600",
    "displayName" : "IL18R1 [plasma membrane]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 49646,
    "diagramIds" : [ 55254 ],
    "identifier" : "A0A8I3N4M4",
    "standardIdentifier" : "uniprot:A0A8I3N4M4",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "IL18R1" ],
    "parents" : [ 10306353, 10306375 ],
    "children" : [ ]
  }, {
    "dbId" : 10316075,
    "stId" : "R-CFA-9007909",
    "displayName" : "IL1F10(?-152):IL1RAPL1 [plasma membrane]",
    "schemaClass" : "Complex",
    "speciesId" : 49646,
    "diagramIds" : [ 55290 ],
    "parents" : [ ],
    "children" : [ 10316055, 10316073 ]
  }, {
    "dbId" : 10257963,
    "stId" : "R-CFA-450121",
    "displayName" : "p-2S,S376,T,T209,T387-IRAK1:TRAF6 [cytosol]",
    "schemaClass" : "Complex",
    "speciesId" : 49646,
    "diagramIds" : [ 55205 ],
    "parents" : [ 10257965 ],
    "children" : [ 10257926, 10238140 ]
  }, {
    "dbId" : 113592,
    "stId" : "R-ALL-113592",
    "displayName" : "ATP [cytosol]",
    "schemaClass" : "SimpleEntity",
    "speciesId" : 0,
    "diagramIds" : [ 55265, 55234, 55186, 55190, 55223, 55179, 55260, 55293, 55247 ],
    "identifier" : "30616",
    "standardIdentifier" : "chebi:30616",
    "referenceType" : "ReferenceMolecule",
    "parents" : [ ],
    "children" : [ ]
  }, {
    "dbId" : 10257957,
    "stId" : "R-CFA-8948065",
    "displayName" : "hp-IRAK1:3xK63polyUb-TRAF6 [cytosol]",
    "schemaClass" : "Complex",
    "speciesId" : 49646,
    "diagramIds" : [ 55214 ],
    "parents" : [ 10257959 ],
    "children" : [ 10257955, 10245353 ]
  }, {
    "dbId" : 29370,
    "stId" : "R-ALL-29370",
    "displayName" : "ADP [cytosol]",
    "schemaClass" : "SimpleEntity",
    "speciesId" : 0,
    "diagramIds" : [ 55249, 55267, 55188, 55237, 55191, 55224, 55180, 55295, 55263 ],
    "identifier" : "456216",
    "standardIdentifier" : "chebi:456216",
    "referenceType" : "ReferenceMolecule",
    "parents" : [ ],
    "children" : [ ]
  }, {
    "dbId" : 10257959,
    "stId" : "R-CFA-450185",
    "displayName" : "hp-IRAK1:K6-poly-Ub oligo-TRAF6:TAK1 complex [cytosol]",
    "schemaClass" : "Complex",
    "speciesId" : 49646,
    "diagramIds" : [ 55215 ],
    "parents" : [ ],
    "children" : [ 10257953, 10257957 ]
  }, {
    "dbId" : 10257953,
    "stId" : "R-CFA-446878",
    "displayName" : "TAK1 complex [cytosol]",
    "schemaClass" : "Complex",
    "speciesId" : 49646,
    "diagramIds" : [ 55213 ],
    "parents" : [ 10257959, 10258513 ],
    "children" : [ 10257939, 10257943, 10257951 ]
  }, {
    "dbId" : 10257955,
    "stId" : "R-CFA-450147",
    "displayName" : "hp-IRAK1:K63polyUb-TRAF6 [cytosol]",
    "schemaClass" : "Complex",
    "speciesId" : 49646,
    "parents" : [ 10257957, 10257971 ],
    "children" : [ 10257926, 10245353 ]
  }, {
    "dbId" : 10257699,
    "stId" : "R-CFA-446125",
    "displayName" : "IL1B,Myr82K-Myr83K-IL1A:IL1R2 [plasma membrane]",
    "schemaClass" : "Complex",
    "speciesId" : 49646,
    "diagramIds" : [ 55165 ],
    "parents" : [ ],
    "children" : [ 10257631, 10257612 ]
  }, {
    "dbId" : 10316124,
    "stId" : "R-CFA-9008597",
    "displayName" : "IL18R1:IL37,IL37(?-218):SIGIRR [plasma membrane]",
    "schemaClass" : "Complex",
    "speciesId" : 49646,
    "diagramIds" : [ 55258 ],
    "parents" : [ ],
    "children" : [ 10306353, 10316122 ]
  }, {
    "dbId" : 10258781,
    "stId" : "R-CFA-450696",
    "displayName" : "PELI1 [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 49646,
    "identifier" : "A0A8I3PJH9",
    "standardIdentifier" : "uniprot:A0A8I3PJH9",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "PELI1" ],
    "parents" : [ 10258791 ],
    "children" : [ ]
  }, {
    "dbId" : 10258777,
    "stId" : "R-CFA-450810",
    "displayName" : "p-2S,S376,T,T209,T387-IRAK1, IRAK4 [cytosol]",
    "schemaClass" : "DefinedSet",
    "speciesId" : 49646,
    "diagramIds" : [ 55219 ],
    "parents" : [ ],
    "children" : [ 10257878, 10257926 ]
  }, {
    "dbId" : 10316122,
    "stId" : "R-CFA-188067",
    "displayName" : "SIGIRR [plasma membrane]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 49646,
    "diagramIds" : [ 55257 ],
    "identifier" : "A0A8I3Q0J2",
    "standardIdentifier" : "uniprot:A0A8I3Q0J2",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "SIGIRR" ],
    "parents" : [ 10316124 ],
    "children" : [ ]
  }, {
    "dbId" : 10306384,
    "stId" : "R-CFA-197596",
    "displayName" : "IL18RAP [plasma membrane]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 49646,
    "diagramIds" : [ 55303 ],
    "identifier" : "A0A8I3RXV6",
    "standardIdentifier" : "uniprot:A0A8I3RXV6",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "IL18RAP" ],
    "parents" : [ 10306386 ],
    "children" : [ ]
  }, {
    "dbId" : 10258513,
    "stId" : "R-CFA-450186",
    "displayName" : "hp-IRAK1:K63polyUboligo-TRAF6:Activated TAK1 complex [cytosol]",
    "schemaClass" : "Complex",
    "speciesId" : 49646,
    "diagramIds" : [ 55217 ],
    "parents" : [ ],
    "children" : [ 10257971, 10257953 ]
  }, {
    "dbId" : 10238290,
    "stId" : "R-CFA-202506",
    "displayName" : "phospho-IKBKB [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 49646,
    "diagramIds" : [ 55251 ],
    "identifier" : "A0A8I3N4F2",
    "standardIdentifier" : "uniprot:A0A8I3N4F2",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "IKBKB" ],
    "parents" : [ ],
    "children" : [ ]
  }, {
    "dbId" : 10306386,
    "stId" : "R-CFA-8848398",
    "displayName" : "IL18:IL18R1:IL18RAP [plasma membrane]",
    "schemaClass" : "Complex",
    "speciesId" : 49646,
    "diagramIds" : [ 55304 ],
    "parents" : [ ],
    "children" : [ 10306384, 10306375 ]
  }, {
    "dbId" : 10329423,
    "stId" : "R-CFA-445989",
    "displayName" : "TAK1-dependent IKK and NF-kappa-B activation  ",
    "schemaClass" : "Pathway",
    "speciesId" : 49646,
    "diagramIds" : [ 55336 ]
  }, {
    "dbId" : 10306377,
    "stId" : "R-CFA-9012548",
    "displayName" : "IL18 [extracellular region]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 49646,
    "diagramIds" : [ 55301 ],
    "identifier" : "A0A8I3RRK2",
    "standardIdentifier" : "uniprot:A0A8I3RRK2",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "IL18" ],
    "parents" : [ ],
    "children" : [ ]
  }, {
    "dbId" : 10306375,
    "stId" : "R-CFA-8848366",
    "displayName" : "IL18:IL18R1 [plasma membrane]",
    "schemaClass" : "Complex",
    "speciesId" : 49646,
    "diagramIds" : [ 55300 ],
    "parents" : [ 10306386 ],
    "children" : [ 10306345, 10258317 ]
  }, {
    "dbId" : 10238278,
    "stId" : "R-CFA-168108",
    "displayName" : "IKBKG [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 49646,
    "identifier" : "A0A8I3S792",
    "standardIdentifier" : "uniprot:A0A8I3S792",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "IKBKG" ],
    "parents" : [ 10245377 ],
    "children" : [ ]
  }, {
    "dbId" : 10330435,
    "stId" : "R-CFA-448706",
    "displayName" : "Interleukin-1 processing",
    "schemaClass" : "Pathway",
    "speciesId" : 49646,
    "diagramIds" : [ 55333 ]
  }, {
    "dbId" : 10258812,
    "stId" : "R-CFA-451411",
    "displayName" : "hp-IRAK1: p-Pellino-1,2,(3) [cytosol]",
    "schemaClass" : "Complex",
    "speciesId" : 49646,
    "parents" : [ 10258816, 10258931 ],
    "children" : [ 10257926, 10258810 ]
  }, {
    "dbId" : 10258814,
    "stId" : "R-CFA-451410",
    "displayName" : "IRAK4: p-Pellino-1,2,3 [cytosol]",
    "schemaClass" : "Complex",
    "speciesId" : 49646,
    "parents" : [ 10313066, 10258816 ],
    "children" : [ 10257878, 10258810 ]
  }, {
    "dbId" : 10258808,
    "stId" : "R-CFA-450806",
    "displayName" : "phospho-PELI3 [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 49646,
    "identifier" : "A0A8I3NZN1",
    "standardIdentifier" : "uniprot:A0A8I3NZN1",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "PELI3" ],
    "parents" : [ 10258810 ],
    "children" : [ ]
  }, {
    "dbId" : 10258810,
    "stId" : "R-CFA-450819",
    "displayName" : "p-Pellino-1,2,(3) [cytosol]",
    "schemaClass" : "CandidateSet",
    "speciesId" : 49646,
    "diagramIds" : [ 55245 ],
    "parents" : [ 10258814, 10258937, 10258812 ],
    "children" : [ 10258802, 10258805, 10258808 ]
  }, {
    "dbId" : 10258805,
    "stId" : "R-CFA-450825",
    "displayName" : "phospho-PELI2 [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 49646,
    "identifier" : "A0A8I3P046",
    "standardIdentifier" : "uniprot:A0A8I3P046",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "PELI2" ],
    "parents" : [ 10258810 ],
    "children" : [ ]
  }, {
    "dbId" : 9681784,
    "stId" : "R-ALL-9681784",
    "displayName" : "anakinra [extracellular region]",
    "schemaClass" : "ProteinDrug",
    "speciesId" : 0,
    "identifier" : "6972",
    "standardIdentifier" : "iuphar.ligand:6972",
    "chebiIdentifier" : "chebi:231683",
    "parents" : [ 9681804 ],
    "children" : [ ]
  }, {
    "dbId" : 10316144,
    "stId" : "R-CFA-9008702",
    "displayName" : "IL36G [nucleoplasm]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 49646,
    "diagramIds" : [ 55273 ],
    "identifier" : "A0A8I3NFJ0",
    "standardIdentifier" : "uniprot:A0A8I3NFJ0",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "IL36G" ],
    "parents" : [ ],
    "children" : [ ]
  }, {
    "dbId" : 10258802,
    "stId" : "R-CFA-450815",
    "displayName" : "phospho-PELI1 [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 49646,
    "identifier" : "A0A8I3PJH9",
    "standardIdentifier" : "uniprot:A0A8I3PJH9",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "PELI1" ],
    "parents" : [ 10258810 ],
    "children" : [ ]
  }, {
    "dbId" : 10316140,
    "stId" : "R-CFA-9008596",
    "displayName" : "IL36G [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 49646,
    "diagramIds" : [ 55316, 55270 ],
    "identifier" : "A0A8I3NFJ0",
    "standardIdentifier" : "uniprot:A0A8I3NFJ0",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "IL36G" ],
    "parents" : [ 10316480 ],
    "children" : [ ]
  }, {
    "dbId" : 10258797,
    "stId" : "R-CFA-451413",
    "displayName" : "hp-IRAK1:Pellino, IRAK4:Pellino [cytosol]",
    "schemaClass" : "DefinedSet",
    "speciesId" : 49646,
    "diagramIds" : [ 55221 ],
    "parents" : [ ],
    "children" : [ 10258795, 10258793 ]
  }, {
    "dbId" : 10313068,
    "stId" : "R-CFA-8948067",
    "displayName" : "IRAK1:Pellino:E2 complexes [cytosol]",
    "schemaClass" : "DefinedSet",
    "speciesId" : 49646,
    "diagramIds" : [ 55243 ],
    "parents" : [ ],
    "children" : [ 10258931, 10313066 ]
  }, {
    "dbId" : 10316136,
    "stId" : "R-CFA-9008698",
    "displayName" : "IL37(?-218):SMAD3 [cytosol]",
    "schemaClass" : "Complex",
    "speciesId" : 49646,
    "diagramIds" : [ 55276 ],
    "parents" : [ ],
    "children" : [ 10316134, 10238921 ]
  }, {
    "dbId" : 10258793,
    "stId" : "R-CFA-451420",
    "displayName" : "hp-IRAK1: Pellino-1,2,3 [cytosol]",
    "schemaClass" : "Complex",
    "speciesId" : 49646,
    "parents" : [ 10258797 ],
    "children" : [ 10258791, 10257926 ]
  }, {
    "dbId" : 10238314,
    "stId" : "R-CFA-194371",
    "displayName" : "phospho-MAPK8 [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 49646,
    "diagramIds" : [ 55294 ],
    "identifier" : "A0A8I3NY64",
    "standardIdentifier" : "uniprot:A0A8I3NY64",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "MAPK8" ],
    "parents" : [ ],
    "children" : [ ]
  }, {
    "dbId" : 10252138,
    "stId" : "R-CFA-539044",
    "displayName" : "STAT3 [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 49646,
    "diagramIds" : [ 55261 ],
    "identifier" : "A0A8I3RV66",
    "standardIdentifier" : "uniprot:A0A8I3RV66",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "STAT3" ],
    "parents" : [ ],
    "children" : [ ]
  }, {
    "dbId" : 9681764,
    "stId" : "R-ALL-9681764",
    "displayName" : "isunakinra [extracellular region]",
    "schemaClass" : "ProteinDrug",
    "speciesId" : 0,
    "identifier" : "9704",
    "standardIdentifier" : "iuphar.ligand:9704",
    "parents" : [ 9681804 ],
    "children" : [ ]
  }, {
    "dbId" : 10258795,
    "stId" : "R-CFA-451416",
    "displayName" : "IRAK4: Pellino-1,2,3 [cytosol]",
    "schemaClass" : "Complex",
    "speciesId" : 49646,
    "parents" : [ 10258797 ],
    "children" : [ 10258791, 10257878 ]
  }, {
    "dbId" : 10258539,
    "stId" : "R-CFA-206255",
    "displayName" : "phospho-MAP2K6 [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 49646,
    "diagramIds" : [ 55236 ],
    "identifier" : "A0A8I3NBF5",
    "standardIdentifier" : "uniprot:A0A8I3NBF5",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "MAP2K6" ],
    "parents" : [ ],
    "children" : [ ]
  }, {
    "dbId" : 10313066,
    "stId" : "R-CFA-8948062",
    "displayName" : "IRAK4: p-Pellino-1,2,3:UBE2N:UBE2V1:K63polyUb [cytosol]",
    "schemaClass" : "Complex",
    "speciesId" : 49646,
    "parents" : [ 10313068 ],
    "children" : [ 10257967, 10258814 ]
  }, {
    "dbId" : 10258789,
    "stId" : "R-CFA-450695",
    "displayName" : "PELI3 [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 49646,
    "identifier" : "A0A8I3NZN1",
    "standardIdentifier" : "uniprot:A0A8I3NZN1",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "PELI3" ],
    "parents" : [ 10258791 ],
    "children" : [ ]
  }, {
    "dbId" : 10259813,
    "stId" : "R-CFA-507716",
    "displayName" : "MAP3K3:SQSTM1:TRAF6 [cytosol]",
    "schemaClass" : "Complex",
    "speciesId" : 49646,
    "diagramIds" : [ 55201 ],
    "parents" : [ ],
    "children" : [ 10259811, 10238140 ]
  }, {
    "dbId" : 10316134,
    "stId" : "R-CFA-9008584",
    "displayName" : "IL36G [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 49646,
    "diagramIds" : [ 55272 ],
    "identifier" : "A0A8I3NFJ0",
    "standardIdentifier" : "uniprot:A0A8I3NFJ0",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "IL36G" ],
    "parents" : [ 10316136, 10316175, 10316486 ],
    "children" : [ ]
  }, {
    "dbId" : 10258791,
    "stId" : "R-CFA-450814",
    "displayName" : "Pellino 1,2,3 [cytosol]",
    "schemaClass" : "DefinedSet",
    "speciesId" : 49646,
    "diagramIds" : [ 55220 ],
    "parents" : [ 10258795, 10258793 ],
    "children" : [ 10258785, 10258789, 10258781 ]
  }, {
    "dbId" : 10316129,
    "stId" : "R-CFA-9008705",
    "displayName" : "phospho-TBK1 [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 49646,
    "diagramIds" : [ 55268 ],
    "identifier" : "A0A8I3NK16",
    "standardIdentifier" : "uniprot:A0A8I3NK16",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "TBK1" ],
    "parents" : [ ],
    "children" : [ ]
  }, {
    "dbId" : 10258785,
    "stId" : "R-CFA-450694",
    "displayName" : "PELI2 [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 49646,
    "identifier" : "A0A8I3P046",
    "standardIdentifier" : "uniprot:A0A8I3P046",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "PELI2" ],
    "parents" : [ 10258791 ],
    "children" : [ ]
  }, {
    "dbId" : 10259809,
    "stId" : "R-CFA-507725",
    "displayName" : "MAP3K3 [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 49646,
    "identifier" : "A0A8I3PGC5",
    "standardIdentifier" : "uniprot:A0A8I3PGC5",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "MAP3K3" ],
    "parents" : [ 10259811 ],
    "children" : [ ]
  }, {
    "dbId" : 10259811,
    "stId" : "R-CFA-507714",
    "displayName" : "MAP3K3:SQSTM1 [cytosol]",
    "schemaClass" : "Complex",
    "speciesId" : 49646,
    "diagramIds" : [ 55200 ],
    "parents" : [ 10259813 ],
    "children" : [ 10259809, 10242441 ]
  } ],
  "edges" : [ {
    "dbId" : 10316061,
    "stId" : "R-CFA-9007901",
    "displayName" : "IL1F10 binds IL1RL2",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "inputs" : [ 10306331, 10306319 ],
    "outputs" : [ 10316059 ],
    "efs" : [ ],
    "diagramIds" : [ 55279 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10316189,
    "stId" : "R-CFA-9009072",
    "displayName" : "STAT3 phosphorylation",
    "schemaClass" : "BlackBoxEvent",
    "speciesId" : 0,
    "preceding" : [ 10316126 ],
    "inputs" : [ 113592, 10252138 ],
    "outputs" : [ 29370, 10315513 ],
    "efs" : [ ],
    "activators" : [ 10316124 ],
    "diagramIds" : [ 55259 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10316057,
    "stId" : "R-CFA-9007882",
    "displayName" : "IL1F10 is cleaved",
    "schemaClass" : "BlackBoxEvent",
    "speciesId" : 0,
    "following" : [ 10316081 ],
    "inputs" : [ 10306331 ],
    "outputs" : [ 10316055, 10316053 ],
    "efs" : [ ],
    "diagramIds" : [ 55283 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10246809,
    "stId" : "R-CFA-209087",
    "displayName" : "IKBA is phosphorylated by Phospho IKKB kinase",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "inputs" : [ 10238256, 113592 ],
    "outputs" : [ 29370, 10238268 ],
    "catalysts" : [ 10238290 ],
    "efs" : [ ],
    "diagramIds" : [ 55246 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10316177,
    "stId" : "R-CFA-9008928",
    "displayName" : "IL37(?-218):p-S423,S425-SMAD3 translocates to the nucleus",
    "schemaClass" : "BlackBoxEvent",
    "speciesId" : 0,
    "preceding" : [ 10316267 ],
    "inputs" : [ 10316175 ],
    "outputs" : [ 10316175 ],
    "efs" : [ ],
    "diagramIds" : [ 55277 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10257937,
    "stId" : "R-CFA-446868",
    "displayName" : "The Interleukin 1 receptor complex binds Tollip",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "inputs" : [ 10257882, 10257886 ],
    "outputs" : [ 10257888 ],
    "efs" : [ ],
    "diagramIds" : [ 55175 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10257935,
    "stId" : "R-CFA-446862",
    "displayName" : "Hyperphosphorylated IRAK1 associates with TRAF6",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "inputs" : [ 10257928, 10238140 ],
    "outputs" : [ 10257933 ],
    "efs" : [ ],
    "diagramIds" : [ 55196 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10257931,
    "stId" : "R-CFA-446701",
    "displayName" : "IRAK4-activated IRAK1 autophosphorylates",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "inputs" : [ 10257920, 113592 ],
    "outputs" : [ 29370, 10257928 ],
    "catalysts" : [ 10257920 ],
    "efs" : [ ],
    "diagramIds" : [ 55189 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10312576,
    "stId" : "R-CFA-8940998",
    "displayName" : "IL36RN, IL1F10 bind IL1RL2",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "inputs" : [ 10306319, 10306333 ],
    "outputs" : [ 10306335 ],
    "efs" : [ ],
    "diagramIds" : [ 55313 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10258946,
    "stId" : "R-CFA-451561",
    "displayName" : "NEMO binds polyubiquitinated IRAK1",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "inputs" : [ 10245377, 10258935 ],
    "outputs" : [ 10258944 ],
    "efs" : [ ],
    "diagramIds" : [ 55229 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10257923,
    "stId" : "R-CFA-446694",
    "displayName" : "IRAK4 phosphorylates IRAK1",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "inputs" : [ 113592, 10257912 ],
    "outputs" : [ 10257920, 29370 ],
    "catalysts" : [ 10257912 ],
    "efs" : [ ],
    "diagramIds" : [ 55185 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10258819,
    "stId" : "R-CFA-450827",
    "displayName" : "hp-IRAK1, hp-IRAK4 4 phosphorylate Pellino-1 and 2",
    "schemaClass" : "BlackBoxEvent",
    "speciesId" : 0,
    "inputs" : [ 113592, 10258797 ],
    "outputs" : [ 10258816, 29370 ],
    "catalysts" : [ 10258797 ],
    "efs" : [ ],
    "diagramIds" : [ 55222 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10257980,
    "stId" : "R-CFA-446894",
    "displayName" : "TRAF6 binding leads to IRAK1:TRAF6 release",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "inputs" : [ 10257933 ],
    "outputs" : [ 10257893, 10257963, 10257880, 10257886 ],
    "efs" : [ ],
    "inhibitors" : [ 10257978 ],
    "diagramIds" : [ 55203 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10316085,
    "stId" : "R-CFA-9008054",
    "displayName" : "IL1F10 binds IL1RAPL1",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "following" : [ 10316077 ],
    "inputs" : [ 10306331, 10316073 ],
    "outputs" : [ 10316083 ],
    "efs" : [ ],
    "diagramIds" : [ 55286 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10257974,
    "stId" : "R-CFA-446877",
    "displayName" : "TRAF6 is K63 poly-ubiquitinated",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "inputs" : [ 10257969 ],
    "outputs" : [ 10257971 ],
    "catalysts" : [ 10257969 ],
    "efs" : [ ],
    "diagramIds" : [ 55209 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10316081,
    "stId" : "R-CFA-9008052",
    "displayName" : "IL1F10(?-152) binds IL1RAPL1",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "preceding" : [ 10316057 ],
    "inputs" : [ 10316055, 10316073 ],
    "outputs" : [ 10316075 ],
    "efs" : [ ],
    "diagramIds" : [ 55289 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10306355,
    "stId" : "R-CFA-8848335",
    "displayName" : "IL37 binds  IL18R1",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "preceding" : [ 10316142 ],
    "following" : [ 10316126 ],
    "inputs" : [ 10306345, 10306349 ],
    "outputs" : [ 10306353 ],
    "efs" : [ ],
    "diagramIds" : [ 55252 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10316077,
    "stId" : "R-CFA-9008043",
    "displayName" : "MAPK8 phosphorylation",
    "schemaClass" : "BlackBoxEvent",
    "speciesId" : 0,
    "preceding" : [ 10316085 ],
    "inputs" : [ 113592, 10235183 ],
    "outputs" : [ 29370, 10238314 ],
    "efs" : [ ],
    "inhibitors" : [ 10316075 ],
    "activators" : [ 10316073 ],
    "diagramIds" : [ 55291 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10257961,
    "stId" : "R-CFA-446870",
    "displayName" : "Polyubiquitinated TRAF6 binds the TAK1 complex",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "inputs" : [ 10257953, 10257957 ],
    "outputs" : [ 10257959 ],
    "efs" : [ ],
    "diagramIds" : [ 55212 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10257701,
    "stId" : "R-CFA-446130",
    "displayName" : "Interleukin-1 receptor type 2 binds Interleukin 1",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "inputs" : [ 10257631, 10257612 ],
    "outputs" : [ 10257699 ],
    "efs" : [ ],
    "diagramIds" : [ 55163 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10306340,
    "stId" : "R-CFA-8848316",
    "displayName" : "IL36 binds IL1RL2",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "following" : [ 10306337 ],
    "inputs" : [ 10306315, 10306319 ],
    "outputs" : [ 10306321 ],
    "efs" : [ ],
    "inhibitors" : [ 10306327 ],
    "diagramIds" : [ 55305 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10306337,
    "stId" : "R-CFA-8848314",
    "displayName" : "IL36:IL1RL2 binds IL1RAP-1",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "preceding" : [ 10306340 ],
    "inputs" : [ 10257618, 10306321 ],
    "outputs" : [ 10306323 ],
    "efs" : [ ],
    "inhibitors" : [ 10306335 ],
    "diagramIds" : [ 55309 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10313053,
    "stId" : "R-CFA-8948018",
    "displayName" : "UBE2N:UBE2V1 dissociates from hp-IRAK1:3xK63-polyUb-TRAF6:3xUBE2N:UBE2V1",
    "schemaClass" : "BlackBoxEvent",
    "speciesId" : 0,
    "inputs" : [ 10257971 ],
    "outputs" : [ 10257957, 10238488 ],
    "efs" : [ ],
    "diagramIds" : [ 55240 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10316126,
    "stId" : "R-CFA-9008577",
    "displayName" : "IL37:IL18R1 binds SIGIRR",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "preceding" : [ 10306355 ],
    "following" : [ 10316189, 10316131 ],
    "inputs" : [ 10306353, 10316122 ],
    "outputs" : [ 10316124 ],
    "efs" : [ ],
    "diagramIds" : [ 55256 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10257626,
    "stId" : "R-CFA-445753",
    "displayName" : "IL1B,Myr82K-Myr83K-IL1A:IL1R1",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "inputs" : [ 10257600, 10257612 ],
    "outputs" : [ 10257614 ],
    "efs" : [ ],
    "inhibitors" : [ 10257624 ],
    "diagramIds" : [ 55158 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10313051,
    "stId" : "R-CFA-8948015",
    "displayName" : "hp-IRAK1:3xTRAF6 binds UBE2N:UBE2V1:K63-polyUb",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "inputs" : [ 10257967, 10257965 ],
    "outputs" : [ 10257969 ],
    "efs" : [ ],
    "diagramIds" : [ 55238 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10306388,
    "stId" : "R-CFA-8848395",
    "displayName" : "IL18:IL18R1 binds IL18RAP",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "preceding" : [ 10306379 ],
    "inputs" : [ 10306384, 10306375 ],
    "outputs" : [ 10306386 ],
    "efs" : [ ],
    "diagramIds" : [ 55302 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10257622,
    "stId" : "R-CFA-445752",
    "displayName" : "Interleukin-1 receptor type 1: Interleukin 1 binds Interleukin-1 receptor accessory protein, membrane associated isoform",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "inputs" : [ 10257618, 10257614 ],
    "outputs" : [ 10257620 ],
    "efs" : [ ],
    "diagramIds" : [ 55166 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10258515,
    "stId" : "R-CFA-450187",
    "displayName" : "TAK1 is activated within the TAK1 complex",
    "schemaClass" : "BlackBoxEvent",
    "speciesId" : 0,
    "inputs" : [ 10257959 ],
    "outputs" : [ 10258513 ],
    "efs" : [ ],
    "diagramIds" : [ 55216 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10258509,
    "stId" : "R-CFA-450133",
    "displayName" : "IL1R1:IL1:IL1RAP binds MYD88 homodimer",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "inputs" : [ 10242513, 10257620 ],
    "outputs" : [ 10257880 ],
    "efs" : [ ],
    "diagramIds" : [ 55169 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10258511,
    "stId" : "R-CFA-450173",
    "displayName" : "IRAK1 induces oligomerisation of TRAF6",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "inputs" : [ 10257963, 10238140 ],
    "outputs" : [ 10257965 ],
    "efs" : [ ],
    "diagramIds" : [ 55207 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10316489,
    "stId" : "R-CFA-9012556",
    "displayName" : "IL37:2x(CASP1(120-197):CASP1(317-404)) cleaves IL37",
    "schemaClass" : "BlackBoxEvent",
    "speciesId" : 0,
    "preceding" : [ 10316482 ],
    "following" : [ 10316517 ],
    "inputs" : [ 10316480 ],
    "outputs" : [ 10316486 ],
    "catalysts" : [ 10316480 ],
    "efs" : [ ],
    "diagramIds" : [ 55319 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10306379,
    "stId" : "R-CFA-8848370",
    "displayName" : "IL18 binds IL18R1",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "following" : [ 10306388 ],
    "inputs" : [ 10306345, 10258317 ],
    "outputs" : [ 10306375 ],
    "efs" : [ ],
    "activators" : [ 10306377 ],
    "diagramIds" : [ 55298 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10316482,
    "stId" : "R-CFA-9012542",
    "displayName" : "IL37 binds 2x(CASP1(120-197):CASP1(317-404))",
    "schemaClass" : "BlackBoxEvent",
    "speciesId" : 0,
    "preceding" : [ 10316517 ],
    "following" : [ 10316489 ],
    "inputs" : [ 10258180, 10316140 ],
    "outputs" : [ 10316480 ],
    "efs" : [ ],
    "diagramIds" : [ 55315 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10258942,
    "stId" : "R-CFA-451418",
    "displayName" : "Pellino ubiquitinates IRAK1",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "inputs" : [ 10258931 ],
    "outputs" : [ 10258939 ],
    "catalysts" : [ 10258931 ],
    "efs" : [ ],
    "diagramIds" : [ 55226 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10257914,
    "stId" : "R-CFA-446692",
    "displayName" : "IRAK1 binds to MYD88 within the IL1R complex",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "inputs" : [ 10257895, 10257910 ],
    "outputs" : [ 10257912 ],
    "efs" : [ ],
    "diagramIds" : [ 55182 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10257908,
    "stId" : "R-CFA-446684",
    "displayName" : "IRAK2 is phosphorylated downstream of IRAK4 following IL1 receptor activation",
    "schemaClass" : "BlackBoxEvent",
    "speciesId" : 0,
    "inputs" : [ 10257895, 10257903 ],
    "outputs" : [ 10257906 ],
    "efs" : [ ],
    "diagramIds" : [ 55193 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10260470,
    "stId" : "R-CFA-727819",
    "displayName" : "TAK1 phosphorylates MKK6",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "inputs" : [ 10258583, 113592 ],
    "outputs" : [ 29370, 10258539 ],
    "catalysts" : [ 10257953 ],
    "efs" : [ ],
    "diagramIds" : [ 55233 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10313072,
    "stId" : "R-CFA-8948066",
    "displayName" : "K63polyUb-IRAK1 dissociates",
    "schemaClass" : "BlackBoxEvent",
    "speciesId" : 0,
    "inputs" : [ 10258939 ],
    "outputs" : [ 10258935, 10258810, 10238488 ],
    "efs" : [ ],
    "diagramIds" : [ 55244 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10316146,
    "stId" : "R-CFA-9008696",
    "displayName" : "IL37(?-218) translocates from the cytosol to the nucleus",
    "schemaClass" : "BlackBoxEvent",
    "speciesId" : 0,
    "preceding" : [ 10316517 ],
    "inputs" : [ 10316134 ],
    "outputs" : [ 10316144 ],
    "efs" : [ ],
    "diagramIds" : [ 55271 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10316142,
    "stId" : "R-CFA-9008694",
    "displayName" : "IL37, IL37(?-218) translocates from cytosol to extracellular region",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "preceding" : [ 10316517 ],
    "following" : [ 10306355 ],
    "inputs" : [ 10316140 ],
    "outputs" : [ 10306349 ],
    "efs" : [ ],
    "diagramIds" : [ 55269 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10258799,
    "stId" : "R-CFA-450690",
    "displayName" : "hp-IRAK1,hp-IRAK4 bind Pellino1,2,3",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "inputs" : [ 10258791, 10258777 ],
    "outputs" : [ 10258797 ],
    "efs" : [ ],
    "diagramIds" : [ 55218 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10313070,
    "stId" : "R-CFA-8948063",
    "displayName" : "hp-IRAK1:p-Pellino, IRAK4:p-Pellino bind UBE2N:UBE2V1",
    "schemaClass" : "BlackBoxEvent",
    "speciesId" : 0,
    "inputs" : [ 10258816, 10257967 ],
    "outputs" : [ 10313068 ],
    "efs" : [ ],
    "diagramIds" : [ 55242 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10257897,
    "stId" : "R-CFA-446634",
    "displayName" : "IRAK4 is activated by autophosphorylation",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "inputs" : [ 10257888, 113592 ],
    "outputs" : [ 10257895, 29370 ],
    "efs" : [ ],
    "diagramIds" : [ 55178 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10316267,
    "stId" : "R-CFA-9009910",
    "displayName" : "IL37(?-218) binds p-S423,S425-SMAD3",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "preceding" : [ 10316517 ],
    "following" : [ 10316177, 10316138 ],
    "inputs" : [ 10238983, 10316134 ],
    "outputs" : [ 10316175 ],
    "efs" : [ ],
    "diagramIds" : [ 55296 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10316138,
    "stId" : "R-CFA-9008692",
    "displayName" : "IL37(?-218) binds SMAD3",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "preceding" : [ 10316517, 10316267 ],
    "inputs" : [ 10316134, 10238921 ],
    "outputs" : [ 10316136 ],
    "efs" : [ ],
    "diagramIds" : [ 55274 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10257899,
    "stId" : "R-CFA-446648",
    "displayName" : "IL1R1:IL1:IL1RAP:MYD88 homodimer binds IRAK4",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "inputs" : [ 10257878, 10257880 ],
    "outputs" : [ 10257882 ],
    "efs" : [ ],
    "diagramIds" : [ 55172 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10316517,
    "stId" : "R-CFA-9012689",
    "displayName" : "IL37(1-?) and IL37 (?-) dissocates from IL37(1-?):IL37(?-218):CASP1(120-197):CASP1(317-404)",
    "schemaClass" : "BlackBoxEvent",
    "speciesId" : 0,
    "preceding" : [ 10316489 ],
    "following" : [ 10316138, 10316142, 10316146, 10316267, 10316482 ],
    "inputs" : [ 10316486 ],
    "outputs" : [ 10316134, 10316484, 10258180 ],
    "efs" : [ ],
    "diagramIds" : [ 55321 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10320229,
    "stId" : "R-CFA-9681763",
    "displayName" : "IL1R1 binds IL1R1 inhibitors",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "inputs" : [ 9681804, 10257600 ],
    "outputs" : [ 10257624 ],
    "efs" : [ ],
    "diagramIds" : [ 55323 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10259815,
    "stId" : "R-CFA-507719",
    "displayName" : "p62:MEKK3 binds to TRAF6",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "inputs" : [ 10259811, 10238140 ],
    "outputs" : [ 10259813 ],
    "efs" : [ ],
    "inhibitors" : [ 10258194 ],
    "diagramIds" : [ 55199 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10316131,
    "stId" : "R-CFA-9008684",
    "displayName" : "TBK1 phosphorylation",
    "schemaClass" : "BlackBoxEvent",
    "speciesId" : 0,
    "preceding" : [ 10316126 ],
    "inputs" : [ 10262545, 113592 ],
    "outputs" : [ 10316129, 29370 ],
    "efs" : [ ],
    "inhibitors" : [ 10316124 ],
    "diagramIds" : [ 55264 ],
    "entityFunctionalStatus" : [ ]
  } ],
  "subpathways" : [ {
    "dbId" : 10331445,
    "stId" : "R-CFA-9008059",
    "displayName" : "Interleukin-37 signaling",
    "events" : [ 10316189, 10316142, 10316126, 10316489, 10316267, 10316138, 10316517, 10316177, 10306355, 10316131, 10316482, 10316146 ]
  }, {
    "dbId" : 10331447,
    "stId" : "R-CFA-9012546",
    "displayName" : "Interleukin-18 signaling",
    "events" : [ 10306379, 10306388 ]
  }, {
    "dbId" : 10329425,
    "stId" : "R-CFA-9020702",
    "displayName" : "Interleukin-1 signaling",
    "events" : [ 10313053, 10246809, 10257626, 10313051, 10257622, 10257937, 10258515, 10258509, 10257935, 10258511, 10257931, 10258946, 10257923, 10258819, 10257980, 10258942, 10257914, 10257908, 10257974, 10260470, 10313072, 10258799, 10313070, 10257897, 10257961, 10257899, 10320229, 10257701, 10259815 ]
  }, {
    "dbId" : 10331443,
    "stId" : "R-CFA-9014826",
    "displayName" : "Interleukin-36 pathway",
    "events" : [ 10306340, 10306337, 10312576 ]
  }, {
    "dbId" : 10331647,
    "stId" : "R-CFA-9007892",
    "displayName" : "Interleukin-38 signaling",
    "events" : [ 10316061, 10316077, 10316057, 10316085, 10316081 ]
  } ]
}