{
  "dbId" : 10329397,
  "stableId" : "R-CFA-168164",
  "displayName" : "Toll Like Receptor 3 (TLR3) Cascade",
  "nodes" : [ {
    "id" : 91505,
    "reactomeId" : 10329423,
    "displayName" : "TAK1-dependent IKK and NF-kappa-B activation",
    "schemaClass" : "Pathway",
    "renderableClass" : "ProcessNode",
    "position" : {
      "x" : 646,
      "y" : 1294
    },
    "minX" : 579,
    "maxX" : 713,
    "minY" : 1265,
    "maxY" : 1324,
    "prop" : {
      "x" : 579,
      "y" : 1265,
      "width" : 134,
      "height" : 59
    },
    "textPosition" : {
      "x" : 582,
      "y" : 1266
    },
    "connectors" : [ ]
  }, {
    "id" : 91475,
    "reactomeId" : 10238029,
    "displayName" : "phospho-IRF3",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 1615,
      "y" : 821
    },
    "minX" : 1553,
    "maxX" : 1684,
    "minY" : 797,
    "maxY" : 869,
    "prop" : {
      "x" : 1553,
      "y" : 803,
      "width" : 125,
      "height" : 37
    },
    "textPosition" : {
      "x" : 1569,
      "y" : 811
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1678,
          "y" : 803
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1678,
          "y" : 803
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 91474,
      "type" : "INPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 2,
        "shape" : {
          "a" : {
            "x" : 1608,
            "y" : 857
          },
          "b" : {
            "x" : 1620,
            "y" : 869
          },
          "type" : "BOX",
          "empty" : true,
          "centre" : {
            "x" : 1614,
            "y" : 863
          }
        }
      }
    } ]
  }, {
    "id" : 91507,
    "reactomeId" : 10328799,
    "displayName" : "Apoptosis",
    "schemaClass" : "Pathway",
    "renderableClass" : "EncapsulatedNode",
    "position" : {
      "x" : 99,
      "y" : 1192
    },
    "minX" : 62,
    "maxX" : 136,
    "minY" : 1177,
    "maxY" : 1208,
    "prop" : {
      "x" : 62,
      "y" : 1177,
      "width" : 74,
      "height" : 31
    },
    "textPosition" : {
      "x" : 63,
      "y" : 1171
    },
    "connectors" : [ ]
  }, {
    "id" : 91506,
    "reactomeId" : 10329395,
    "displayName" : "MAP kinase activation",
    "schemaClass" : "Pathway",
    "renderableClass" : "ProcessNode",
    "position" : {
      "x" : 1025,
      "y" : 1273
    },
    "minX" : 982,
    "maxX" : 1069,
    "minY" : 1251,
    "maxY" : 1296,
    "prop" : {
      "x" : 982,
      "y" : 1251,
      "width" : 87,
      "height" : 45
    },
    "textPosition" : {
      "x" : 980,
      "y" : 1252
    },
    "connectors" : [ ]
  }, {
    "id" : 91492,
    "reactomeId" : 10235135,
    "displayName" : "active caspase-8",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 96,
      "y" : 722
    },
    "minX" : 42,
    "maxX" : 156,
    "minY" : 705,
    "maxY" : 734,
    "prop" : {
      "x" : 42,
      "y" : 711,
      "width" : 108,
      "height" : 23
    },
    "textPosition" : {
      "x" : 43,
      "y" : 699
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 150,
          "y" : 711
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 150,
          "y" : 711
        }
      }
    },
    "connectors" : [ ]
  }, {
    "id" : 91476,
    "reactomeId" : 10238511,
    "displayName" : "p-T,4S-IRF3:p-T,4S-IRF3",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 1616,
      "y" : 936
    },
    "minX" : 1550,
    "maxX" : 1688,
    "minY" : 912,
    "maxY" : 955,
    "prop" : {
      "x" : 1550,
      "y" : 918,
      "width" : 132,
      "height" : 37
    },
    "textPosition" : {
      "x" : 1554,
      "y" : 919
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1682,
          "y" : 918
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1682,
          "y" : 918
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 91474,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 91477,
      "type" : "INPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 91508,
    "reactomeId" : 10329109,
    "displayName" : "Regulated Necrosis",
    "schemaClass" : "Pathway",
    "renderableClass" : "EncapsulatedNode",
    "position" : {
      "x" : 215,
      "y" : 1192
    },
    "minX" : 151,
    "maxX" : 279,
    "minY" : 1177,
    "maxY" : 1208,
    "prop" : {
      "x" : 151,
      "y" : 1177,
      "width" : 128,
      "height" : 31
    },
    "textPosition" : {
      "x" : 173,
      "y" : 1171
    },
    "connectors" : [ ]
  }, {
    "id" : 91478,
    "reactomeId" : 10240525,
    "displayName" : "p-T,4S-IRF3:p-T,4S-IRF3",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 1666,
      "y" : 1063
    },
    "minX" : 1600,
    "maxX" : 1738,
    "minY" : 1039,
    "maxY" : 1082,
    "prop" : {
      "x" : 1600,
      "y" : 1045,
      "width" : 132,
      "height" : 37
    },
    "textPosition" : {
      "x" : 1604,
      "y" : 1046
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1732,
          "y" : 1045
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1732,
          "y" : 1045
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 91477,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 91500,
    "reactomeId" : 10258570,
    "displayName" : "K63pUb-TRAF6:TAB1:TAB2,TAB3:free pUb:p-T-TAK1",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 1020,
      "y" : 1166
    },
    "minX" : 957,
    "maxX" : 1089,
    "minY" : 1135,
    "maxY" : 1192,
    "prop" : {
      "x" : 957,
      "y" : 1141,
      "width" : 126,
      "height" : 51
    },
    "textPosition" : {
      "x" : 960,
      "y" : 1143
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1083,
          "y" : 1141
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1083,
          "y" : 1141
        }
      }
    },
    "connectors" : [ ]
  } ],
  "edges" : [ {
    "id" : 91474,
    "reactomeId" : 10238513,
    "displayName" : "Dimerization of phosphorylated IRF3/IRF7",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 1614,
      "y" : 880
    },
    "minX" : 1608,
    "maxX" : 1620,
    "minY" : 846,
    "maxY" : 912,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 1614,
        "y" : 846
      },
      "to" : {
        "x" : 1614,
        "y" : 880
      }
    }, {
      "from" : {
        "x" : 1614,
        "y" : 880
      },
      "to" : {
        "x" : 1615,
        "y" : 912
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 1611,
        "y" : 905
      },
      "b" : {
        "x" : 1615,
        "y" : 912
      },
      "c" : {
        "x" : 1619,
        "y" : 905
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 1619,
        "y" : 905
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 1614,
        "y" : 880
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 1614,
        "y" : 880
      }
    },
    "inputs" : [ {
      "id" : 91475,
      "stoichiometry" : 2
    } ],
    "outputs" : [ {
      "id" : 91476
    } ]
  }, {
    "id" : 91477,
    "reactomeId" : 10240527,
    "displayName" : "Dimerized phospho-IRF3/IRF7 is transported to the nucleus",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 1617,
      "y" : 985
    },
    "minX" : 1611,
    "maxX" : 1654,
    "minY" : 961,
    "maxY" : 1039,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 1616,
        "y" : 961
      },
      "to" : {
        "x" : 1617,
        "y" : 985
      }
    }, {
      "from" : {
        "x" : 1617,
        "y" : 985
      },
      "to" : {
        "x" : 1654,
        "y" : 1039
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 1647,
        "y" : 1036
      },
      "b" : {
        "x" : 1654,
        "y" : 1039
      },
      "c" : {
        "x" : 1653,
        "y" : 1031
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 1653,
        "y" : 1031
      }
    },
    "reactionShape" : {
      "a" : {
        "x" : 1611,
        "y" : 979
      },
      "b" : {
        "x" : 1623,
        "y" : 991
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 1617,
        "y" : 985
      }
    },
    "inputs" : [ {
      "id" : 91476
    } ],
    "outputs" : [ {
      "id" : 91478
    } ]
  } ],
  "compartments" : [ {
    "id" : 91489,
    "reactomeId" : 7660,
    "displayName" : "nucleoplasm",
    "schemaClass" : "Compartment",
    "renderableClass" : "Compartment",
    "position" : {
      "x" : 1674,
      "y" : 1092
    },
    "minX" : 1561,
    "maxX" : 1788,
    "minY" : 978,
    "maxY" : 1207,
    "prop" : {
      "x" : 1561,
      "y" : 978,
      "width" : 227,
      "height" : 229
    },
    "textPosition" : {
      "x" : 1613,
      "y" : 1130
    },
    "insets" : {
      "x" : 1571,
      "y" : 988,
      "width" : 207,
      "height" : 209
    },
    "bgColor" : {
      "r" : 250,
      "g" : 240,
      "b" : 240
    },
    "componentIds" : [ 91477, 91478 ]
  }, {
    "id" : 91479,
    "reactomeId" : 70101,
    "displayName" : "cytosol",
    "schemaClass" : "Compartment",
    "renderableClass" : "Compartment",
    "position" : {
      "x" : 913,
      "y" : 689
    },
    "minX" : 0,
    "maxX" : 1827,
    "minY" : 0,
    "maxY" : 1379,
    "prop" : {
      "x" : 0,
      "y" : 0,
      "width" : 1827,
      "height" : 1379
    },
    "textPosition" : {
      "x" : 74,
      "y" : 43
    },
    "insets" : {
      "x" : 10,
      "y" : 10,
      "width" : 1807,
      "height" : 1359
    },
    "bgColor" : {
      "r" : 250,
      "g" : 240,
      "b" : 240
    },
    "componentIds" : [ 91480, 91474, 91476, 91489, 91475, 91492, 91500, 91505, 91506, 91517, 91518, 91519, 91507, 91508, 91520, 91521 ]
  }, {
    "id" : 91480,
    "reactomeId" : 17940,
    "displayName" : "endosome",
    "schemaClass" : "Compartment",
    "renderableClass" : "Compartment",
    "position" : {
      "x" : 754,
      "y" : 617
    },
    "minX" : 192,
    "maxX" : 1316,
    "minY" : 125,
    "maxY" : 1109,
    "prop" : {
      "x" : 192,
      "y" : 125,
      "width" : 1124,
      "height" : 984
    },
    "textPosition" : {
      "x" : 1080,
      "y" : 178
    },
    "insets" : {
      "x" : 202,
      "y" : 135,
      "width" : 1104,
      "height" : 964
    },
    "bgColor" : {
      "r" : 250,
      "g" : 240,
      "b" : 240
    },
    "componentIds" : [ 91516, 91522 ]
  } ],
  "notes" : [ ],
  "links" : [ {
    "id" : 91521,
    "renderableClass" : "Interaction",
    "position" : {
      "x" : 20,
      "y" : 937
    },
    "minX" : 14,
    "maxX" : 70,
    "minY" : 724,
    "maxY" : 1174,
    "interactionType" : "Activate",
    "segments" : [ {
      "from" : {
        "x" : 39,
        "y" : 724
      },
      "to" : {
        "x" : 20,
        "y" : 725
      }
    }, {
      "from" : {
        "x" : 20,
        "y" : 725
      },
      "to" : {
        "x" : 20,
        "y" : 1149
      }
    }, {
      "from" : {
        "x" : 20,
        "y" : 1149
      },
      "to" : {
        "x" : 70,
        "y" : 1174
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 62,
        "y" : 1174
      },
      "b" : {
        "x" : 70,
        "y" : 1174
      },
      "c" : {
        "x" : 66,
        "y" : 1167
      },
      "type" : "ARROW",
      "empty" : true,
      "centre" : {
        "x" : 66,
        "y" : 1167
      }
    },
    "reactionShape" : {
      "a" : {
        "x" : 14,
        "y" : 931
      },
      "b" : {
        "x" : 26,
        "y" : 943
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 20,
        "y" : 937
      }
    },
    "inputs" : [ {
      "id" : 91492
    } ],
    "outputs" : [ {
      "id" : 91507
    } ]
  }, {
    "id" : 91517,
    "renderableClass" : "Interaction",
    "position" : {
      "x" : 1021,
      "y" : 1221
    },
    "minX" : 1015,
    "maxX" : 1027,
    "minY" : 1195,
    "maxY" : 1248,
    "interactionType" : "Activate",
    "segments" : [ {
      "from" : {
        "x" : 1020,
        "y" : 1195
      },
      "to" : {
        "x" : 1023,
        "y" : 1248
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 1019,
        "y" : 1241
      },
      "b" : {
        "x" : 1023,
        "y" : 1248
      },
      "c" : {
        "x" : 1027,
        "y" : 1241
      },
      "type" : "ARROW",
      "empty" : true,
      "centre" : {
        "x" : 1027,
        "y" : 1241
      }
    },
    "reactionShape" : {
      "a" : {
        "x" : 1015,
        "y" : 1215
      },
      "b" : {
        "x" : 1027,
        "y" : 1227
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 1021,
        "y" : 1221
      }
    },
    "inputs" : [ {
      "id" : 91500
    } ],
    "outputs" : [ {
      "id" : 91506
    } ]
  }, {
    "id" : 91518,
    "renderableClass" : "Interaction",
    "position" : {
      "x" : 691,
      "y" : 1249
    },
    "minX" : 675,
    "maxX" : 954,
    "minY" : 1181,
    "maxY" : 1262,
    "interactionType" : "Activate",
    "segments" : [ {
      "from" : {
        "x" : 954,
        "y" : 1181
      },
      "to" : {
        "x" : 691,
        "y" : 1249
      }
    }, {
      "from" : {
        "x" : 691,
        "y" : 1249
      },
      "to" : {
        "x" : 675,
        "y" : 1262
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 678,
        "y" : 1255
      },
      "b" : {
        "x" : 675,
        "y" : 1262
      },
      "c" : {
        "x" : 683,
        "y" : 1261
      },
      "type" : "ARROW",
      "empty" : true,
      "centre" : {
        "x" : 683,
        "y" : 1261
      }
    },
    "reactionShape" : {
      "a" : {
        "x" : 685,
        "y" : 1243
      },
      "b" : {
        "x" : 697,
        "y" : 1255
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 691,
        "y" : 1249
      }
    },
    "inputs" : [ {
      "id" : 91500
    } ],
    "outputs" : [ {
      "id" : 91505
    } ]
  } ],
  "shadows" : [ {
    "id" : 91522,
    "reactomeId" : 10329435,
    "displayName" : "TICAM1-dependent activation of IRF3/IRF7",
    "schemaClass" : "Pathway",
    "renderableClass" : "Shadow",
    "position" : {
      "x" : 1641,
      "y" : 942
    },
    "minX" : 1540,
    "maxX" : 1742,
    "minY" : 793,
    "maxY" : 1092,
    "prop" : {
      "x" : 1540,
      "y" : 793,
      "width" : 202,
      "height" : 299
    },
    "points" : [ {
      "x" : 1540,
      "y" : 793
    }, {
      "x" : 1742,
      "y" : 793
    }, {
      "x" : 1742,
      "y" : 1092
    }, {
      "x" : 1540,
      "y" : 1092
    } ],
    "colour" : "#4684ee"
  } ],
  "minX" : 0,
  "maxX" : 1827,
  "minY" : 0,
  "maxY" : 1379,
  "disease" : false
}