{ "dbId" : 10329395, "stableId" : "R-CFA-450294", "displayName" : "MAP kinase activation", "nodes" : [ { "id" : 21024, "reactomeId" : 29370, "displayName" : "ADP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1104, "y" : 280 }, "minX" : 1051, "maxX" : 1126, "minY" : 265, "maxY" : 323, "prop" : { "x" : 1084, "y" : 266, "width" : 41, "height" : 29 }, "textPosition" : { "x" : 1088, "y" : 270 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1120, "y" : 271 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1120, "y" : 271 } } }, "connectors" : [ { "edgeId" : 21020, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 1086, "y" : 298 }, "to" : { "x" : 1051, "y" : 323 } } ], "stoichiometry" : { "value" : 2, "shape" : { "a" : { "x" : 1062, "y" : 304 }, "b" : { "x" : 1074, "y" : 316 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1068, "y" : 310 } } }, "endShape" : { "a" : { "x" : 1083, "y" : 305 }, "b" : { "x" : 1086, "y" : 298 }, "c" : { "x" : 1078, "y" : 299 }, "type" : "ARROW", "centre" : { "x" : 1078, "y" : 299 } } } ] }, { "id" : 21026, "reactomeId" : 10238224, "displayName" : "p-MAPK8,9,10", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 861, "y" : 638 }, "minX" : 806, "maxX" : 916, "minY" : 614, "maxY" : 663, "prop" : { "x" : 806, "y" : 614, "width" : 110, "height" : 49 }, "textPosition" : { "x" : 814, "y" : 628 }, "connectors" : [ { "edgeId" : 21025, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 21028, "reactomeId" : 10258585, "displayName" : "MAP2K3,MAP2K6", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 1273, "y" : 46 }, "minX" : 1213, "maxX" : 1343, "minY" : 37, "maxY" : 79, "prop" : { "x" : 1213, "y" : 37, "width" : 121, "height" : 19 }, "textPosition" : { "x" : 1218, "y" : 36 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "connectors" : [ { "edgeId" : 21027, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1293, "y" : 62 }, "to" : { "x" : 1343, "y" : 79 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 21029, "reactomeId" : 113592, "displayName" : "ATP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1391, "y" : 50 }, "minX" : 1343, "maxX" : 1412, "minY" : 35, "maxY" : 79, "prop" : { "x" : 1372, "y" : 36, "width" : 39, "height" : 29 }, "textPosition" : { "x" : 1376, "y" : 40 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1406, "y" : 41 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1406, "y" : 41 } } }, "connectors" : [ { "edgeId" : 21027, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1369, "y" : 61 }, "to" : { "x" : 1343, "y" : 79 } } ], "stoichiometry" : { "value" : 2, "shape" : { "a" : { "x" : 1350, "y" : 64 }, "b" : { "x" : 1362, "y" : 76 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1356, "y" : 70 } } } } ] }, { "id" : 21030, "reactomeId" : 10258541, "displayName" : "p-S218,T222-MAP2K3, p-S207,T211-MAP2K6", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 1274, "y" : 207 }, "minX" : 1191, "maxX" : 1357, "minY" : 155, "maxY" : 228, "prop" : { "x" : 1191, "y" : 187, "width" : 166, "height" : 41 }, "textPosition" : { "x" : 1194, "y" : 190 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "connectors" : [ { "edgeId" : 21027, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 1300, "y" : 181 }, "to" : { "x" : 1342, "y" : 155 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1304, "y" : 174 }, "b" : { "x" : 1300, "y" : 181 }, "c" : { "x" : 1308, "y" : 181 }, "type" : "ARROW", "centre" : { "x" : 1308, "y" : 181 } } }, { "edgeId" : 21032, "type" : "INPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 21031, "reactomeId" : 29370, "displayName" : "ADP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1410, "y" : 207 }, "minX" : 1342, "maxX" : 1432, "minY" : 155, "maxY" : 222, "prop" : { "x" : 1390, "y" : 193, "width" : 41, "height" : 29 }, "textPosition" : { "x" : 1394, "y" : 197 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1426, "y" : 198 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1426, "y" : 198 } } }, "connectors" : [ { "edgeId" : 21027, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 1391, "y" : 190 }, "to" : { "x" : 1342, "y" : 155 } } ], "stoichiometry" : { "value" : 2, "shape" : { "a" : { "x" : 1360, "y" : 166 }, "b" : { "x" : 1372, "y" : 178 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1366, "y" : 172 } } }, "endShape" : { "a" : { "x" : 1383, "y" : 189 }, "b" : { "x" : 1391, "y" : 190 }, "c" : { "x" : 1388, "y" : 183 }, "type" : "ARROW", "centre" : { "x" : 1388, "y" : 183 } } } ] }, { "id" : 21033, "reactomeId" : 10258547, "displayName" : "p-S189,T193-MAP2K3, p-S207,T211-MAP2K6", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 1274, "y" : 576 }, "minX" : 1198, "maxX" : 1351, "minY" : 560, "maxY" : 593, "prop" : { "x" : 1198, "y" : 560, "width" : 153, "height" : 33 }, "textPosition" : { "x" : 1200, "y" : 559 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "connectors" : [ { "edgeId" : 21032, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 21038, "reactomeId" : 10329393, "displayName" : "MAPK targets/ Nuclear events mediated by MAP kinases", "schemaClass" : "Pathway", "renderableClass" : "ProcessNode", "position" : { "x" : 860, "y" : 766 }, "minX" : 793, "maxX" : 928, "minY" : 725, "maxY" : 808, "prop" : { "x" : 793, "y" : 725, "width" : 135, "height" : 83 }, "textPosition" : { "x" : 797, "y" : 731 }, "connectors" : [ ] }, { "id" : 21041, "reactomeId" : 10328997, "displayName" : "RAF-independent MAPK1/3 activation", "schemaClass" : "Pathway", "renderableClass" : "EncapsulatedNode", "position" : { "x" : 594, "y" : 767 }, "minX" : 503, "maxX" : 685, "minY" : 732, "maxY" : 802, "prop" : { "x" : 503, "y" : 732, "width" : 182, "height" : 70 }, "textPosition" : { "x" : 502, "y" : 745 }, "connectors" : [ ] }, { "id" : 21015, "reactomeId" : 10258559, "displayName" : "MAP2K7,MAP2K4", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 1040, "y" : 49 }, "minX" : 975, "maxX" : 1105, "minY" : 38, "maxY" : 89, "prop" : { "x" : 975, "y" : 38, "width" : 130, "height" : 22 }, "textPosition" : { "x" : 985, "y" : 38 }, "connectors" : [ { "edgeId" : 21014, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1056, "y" : 66 }, "to" : { "x" : 1101, "y" : 89 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 21016, "reactomeId" : 113592, "displayName" : "ATP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1153, "y" : 49 }, "minX" : 1101, "maxX" : 1174, "minY" : 34, "maxY" : 89, "prop" : { "x" : 1134, "y" : 35, "width" : 39, "height" : 29 }, "textPosition" : { "x" : 1138, "y" : 39 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1168, "y" : 40 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1168, "y" : 40 } } }, "connectors" : [ { "edgeId" : 21014, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1131, "y" : 64 }, "to" : { "x" : 1101, "y" : 89 } } ], "stoichiometry" : { "value" : 2, "shape" : { "a" : { "x" : 1110, "y" : 70 }, "b" : { "x" : 1122, "y" : 82 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1116, "y" : 76 } } } } ] }, { "id" : 21017, "reactomeId" : 10238334, "displayName" : "p-MAP2K4/p-MAP2K7", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 1027, "y" : 214 }, "minX" : 973, "maxX" : 1102, "minY" : 165, "maxY" : 317, "prop" : { "x" : 973, "y" : 197, "width" : 109, "height" : 35 }, "textPosition" : { "x" : 985, "y" : 197 }, "connectors" : [ { "edgeId" : 21014, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 1053, "y" : 191 }, "to" : { "x" : 1102, "y" : 165 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1057, "y" : 184 }, "b" : { "x" : 1053, "y" : 191 }, "c" : { "x" : 1061, "y" : 191 }, "type" : "ARROW", "centre" : { "x" : 1061, "y" : 191 } } }, { "edgeId" : 21020, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 1026, "y" : 238 }, "to" : { "x" : 1026, "y" : 309 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 1026, "y" : 313 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1026, "y" : 313 } } } ] }, { "id" : 21018, "reactomeId" : 29370, "displayName" : "ADP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1137, "y" : 213 }, "minX" : 1102, "maxX" : 1159, "minY" : 165, "maxY" : 228, "prop" : { "x" : 1117, "y" : 199, "width" : 41, "height" : 29 }, "textPosition" : { "x" : 1121, "y" : 203 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1153, "y" : 204 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1153, "y" : 204 } } }, "connectors" : [ { "edgeId" : 21014, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 1126, "y" : 196 }, "to" : { "x" : 1102, "y" : 165 } } ], "stoichiometry" : { "value" : 2, "shape" : { "a" : { "x" : 1108, "y" : 174 }, "b" : { "x" : 1120, "y" : 186 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1114, "y" : 180 } } }, "endShape" : { "a" : { "x" : 1119, "y" : 193 }, "b" : { "x" : 1126, "y" : 196 }, "c" : { "x" : 1125, "y" : 188 }, "type" : "ARROW", "centre" : { "x" : 1125, "y" : 188 } } } ] }, { "id" : 21019, "reactomeId" : 10258576, "displayName" : "Activated TAK complexes", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 1224, "y" : 122 }, "minX" : 1110, "maxX" : 1333, "minY" : 101, "maxY" : 143, "prop" : { "x" : 1153, "y" : 101, "width" : 143, "height" : 42 }, "textPosition" : { "x" : 1176, "y" : 104 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "connectors" : [ { "edgeId" : 21027, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 1302, "y" : 120 }, "to" : { "x" : 1325, "y" : 120 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 1329, "y" : 120 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1329, "y" : 120 } } }, { "edgeId" : 21014, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 1147, "y" : 121 }, "to" : { "x" : 1118, "y" : 121 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 1114, "y" : 121 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1114, "y" : 121 } } } ] }, { "id" : 21052, "reactomeId" : 10245379, "displayName" : "CHUK:p-S177,S181-IKBKB:IKBKG", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 643, "y" : 461 }, "minX" : 581, "maxX" : 712, "minY" : 437, "maxY" : 480, "prop" : { "x" : 581, "y" : 443, "width" : 125, "height" : 37 }, "textPosition" : { "x" : 586, "y" : 445 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 706, "y" : 443 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 706, "y" : 443 } } }, "connectors" : [ ] }, { "id" : 21053, "reactomeId" : 10329423, "displayName" : "TAK1-dependent IKK and NF-kappa-B activation", "schemaClass" : "Pathway", "renderableClass" : "EncapsulatedNode", "position" : { "x" : 644, "y" : 557 }, "minX" : 577, "maxX" : 711, "minY" : 528, "maxY" : 587, "prop" : { "x" : 577, "y" : 528, "width" : 134, "height" : 59 }, "textPosition" : { "x" : 580, "y" : 529 }, "connectors" : [ ] }, { "id" : 21021, "reactomeId" : 10238312, "displayName" : "MAPK8,9,10", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 954, "y" : 369 }, "minX" : 908, "maxX" : 1000, "minY" : 326, "maxY" : 384, "prop" : { "x" : 908, "y" : 354, "width" : 92, "height" : 30 }, "textPosition" : { "x" : 913, "y" : 358 }, "connectors" : [ { "edgeId" : 21020, "type" : "INPUT", "segments" : [ { "from" : { "x" : 966, "y" : 348 }, "to" : { "x" : 991, "y" : 326 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 21022, "reactomeId" : 113592, "displayName" : "ATP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 945, "y" : 282 }, "minX" : 926, "maxX" : 991, "minY" : 267, "maxY" : 326, "prop" : { "x" : 926, "y" : 268, "width" : 39, "height" : 29 }, "textPosition" : { "x" : 930, "y" : 272 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 960, "y" : 273 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 960, "y" : 273 } } }, "connectors" : [ { "edgeId" : 21020, "type" : "INPUT", "segments" : [ { "from" : { "x" : 960, "y" : 300 }, "to" : { "x" : 991, "y" : 326 } } ], "stoichiometry" : { "value" : 2, "shape" : { "a" : { "x" : 969, "y" : 307 }, "b" : { "x" : 981, "y" : 319 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 975, "y" : 313 } } } } ] }, { "id" : 21023, "reactomeId" : 10238320, "displayName" : "p-MAPK8,9,10", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 1089, "y" : 370 }, "minX" : 1033, "maxX" : 1146, "minY" : 323, "maxY" : 387, "prop" : { "x" : 1033, "y" : 354, "width" : 113, "height" : 33 }, "textPosition" : { "x" : 1043, "y" : 360 }, "connectors" : [ { "edgeId" : 21025, "type" : "INPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 21020, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 1075, "y" : 348 }, "to" : { "x" : 1051, "y" : 323 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1067, "y" : 346 }, "b" : { "x" : 1075, "y" : 348 }, "c" : { "x" : 1073, "y" : 340 }, "type" : "ARROW", "centre" : { "x" : 1073, "y" : 340 } } } ] } ], "edges" : [ { "id" : 21025, "reactomeId" : 10258589, "displayName" : "Activated human JNKs migrate to nucleoplasm", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 993, "y" : 485 }, "minX" : 882, "maxX" : 1075, "minY" : 393, "maxY" : 608, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 1075, "y" : 393 }, "to" : { "x" : 993, "y" : 485 } }, { "from" : { "x" : 993, "y" : 485 }, "to" : { "x" : 882, "y" : 608 } } ], "endShape" : { "a" : { "x" : 884, "y" : 600 }, "b" : { "x" : 882, "y" : 608 }, "c" : { "x" : 890, "y" : 606 }, "type" : "ARROW", "centre" : { "x" : 890, "y" : 606 } }, "reactionShape" : { "a" : { "x" : 987, "y" : 479 }, "b" : { "x" : 999, "y" : 491 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 993, "y" : 485 } }, "inputs" : [ { "id" : 21023 } ], "outputs" : [ { "id" : 21026 } ] }, { "id" : 21027, "reactomeId" : 10258587, "displayName" : "activated human TAK1 phosphorylates MKK3/MKK6", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 1341, "y" : 120 }, "minX" : 1335, "maxX" : 1347, "minY" : 79, "maxY" : 155, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 1343, "y" : 79 }, "to" : { "x" : 1341, "y" : 120 } }, { "from" : { "x" : 1341, "y" : 120 }, "to" : { "x" : 1342, "y" : 155 } } ], "reactionShape" : { "a" : { "x" : 1335, "y" : 114 }, "b" : { "x" : 1347, "y" : 126 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1341, "y" : 120 } }, "inputs" : [ { "id" : 21028, "points" : [ { "x" : 1293, "y" : 62 } ] }, { "id" : 21029, "points" : [ { "x" : 1369, "y" : 61 } ], "stoichiometry" : 2 } ], "outputs" : [ { "id" : 21030, "points" : [ { "x" : 1300, "y" : 181 } ] }, { "id" : 21031, "points" : [ { "x" : 1391, "y" : 190 } ], "stoichiometry" : 2 } ], "catalysts" : [ { "id" : 21019, "points" : [ { "x" : 1302, "y" : 120 } ] } ] }, { "id" : 21014, "reactomeId" : 10258579, "displayName" : "Activated TAK1 phosphorylates MKK4/MKK7", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 1102, "y" : 121 }, "minX" : 1096, "maxX" : 1108, "minY" : 89, "maxY" : 165, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 1101, "y" : 89 }, "to" : { "x" : 1102, "y" : 121 } }, { "from" : { "x" : 1102, "y" : 121 }, "to" : { "x" : 1102, "y" : 165 } } ], "reactionShape" : { "a" : { "x" : 1096, "y" : 115 }, "b" : { "x" : 1108, "y" : 127 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1102, "y" : 121 } }, "inputs" : [ { "id" : 21015, "points" : [ { "x" : 1056, "y" : 66 } ] }, { "id" : 21016, "points" : [ { "x" : 1131, "y" : 64 } ], "stoichiometry" : 2 } ], "outputs" : [ { "id" : 21017, "points" : [ { "x" : 1053, "y" : 191 } ] }, { "id" : 21018, "points" : [ { "x" : 1126, "y" : 196 } ], "stoichiometry" : 2 } ], "catalysts" : [ { "id" : 21019, "points" : [ { "x" : 1147, "y" : 121 } ] } ] }, { "id" : 21032, "reactomeId" : 10258549, "displayName" : "Phosphorylated MKK3/MKK6 migrates to nucleus", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 1272, "y" : 479 }, "minX" : 1266, "maxX" : 1278, "minY" : 234, "maxY" : 554, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 1273, "y" : 234 }, "to" : { "x" : 1272, "y" : 479 } }, { "from" : { "x" : 1272, "y" : 479 }, "to" : { "x" : 1273, "y" : 554 } } ], "endShape" : { "a" : { "x" : 1269, "y" : 547 }, "b" : { "x" : 1273, "y" : 554 }, "c" : { "x" : 1277, "y" : 547 }, "type" : "ARROW", "centre" : { "x" : 1277, "y" : 547 } }, "reactionShape" : { "a" : { "x" : 1266, "y" : 473 }, "b" : { "x" : 1278, "y" : 485 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1272, "y" : 479 } }, "inputs" : [ { "id" : 21030 } ], "outputs" : [ { "id" : 21033 } ] }, { "id" : 21020, "reactomeId" : 10238337, "displayName" : "Phosphorylation of human JNKs by activated MKK4/MKK7", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 1026, "y" : 325 }, "minX" : 991, "maxX" : 1051, "minY" : 319, "maxY" : 331, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 991, "y" : 326 }, "to" : { "x" : 1026, "y" : 325 } }, { "from" : { "x" : 1026, "y" : 325 }, "to" : { "x" : 1051, "y" : 323 } } ], "reactionShape" : { "a" : { "x" : 1020, "y" : 319 }, "b" : { "x" : 1032, "y" : 331 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1026, "y" : 325 } }, "inputs" : [ { "id" : 21021, "points" : [ { "x" : 966, "y" : 348 } ] }, { "id" : 21022, "points" : [ { "x" : 960, "y" : 300 } ], "stoichiometry" : 2 } ], "outputs" : [ { "id" : 21023, "points" : [ { "x" : 1075, "y" : 348 } ] }, { "id" : 21024, "points" : [ { "x" : 1086, "y" : 298 } ], "stoichiometry" : 2 } ], "catalysts" : [ { "id" : 21017, "points" : [ { "x" : 1026, "y" : 238 } ] } ] } ], "compartments" : [ { "id" : 21040, "reactomeId" : 7660, "displayName" : "nucleoplasm", "schemaClass" : "Compartment", "renderableClass" : "Compartment", "position" : { "x" : 1263, "y" : 708 }, "minX" : 744, "maxX" : 1782, "minY" : 525, "maxY" : 891, "prop" : { "x" : 744, "y" : 525, "width" : 1038, "height" : 366 }, "textPosition" : { "x" : 776, "y" : 835 }, "insets" : { "x" : 754, "y" : 535, "width" : 1018, "height" : 346 }, "bgColor" : { "r" : 250, "g" : 240, "b" : 240 }, "componentIds" : [ 21026, 21033, 21038, 21054 ] }, { "id" : 21039, "reactomeId" : 70101, "displayName" : "cytosol", "schemaClass" : "Compartment", "renderableClass" : "Compartment", "position" : { "x" : 932, "y" : 474 }, "minX" : 0, "maxX" : 1864, "minY" : 0, "maxY" : 948, "prop" : { "x" : 0, "y" : 0, "width" : 1864, "height" : 948 }, "textPosition" : { "x" : 42, "y" : 882 }, "insets" : { "x" : 10, "y" : 10, "width" : 1844, "height" : 928 }, "bgColor" : { "r" : 250, "g" : 240, "b" : 240 }, "componentIds" : [ 21022, 21024, 21015, 21016, 21017, 21021, 21023, 21030, 21019, 21031, 21018, 21014, 21020, 21027, 21028, 21029, 21055, 21041, 21040, 21025, 21057, 21058, 21032, 21056, 21052, 21053, 21059 ] } ], "notes" : [ ], "links" : [ { "id" : 21056, "renderableClass" : "FlowLine", "position" : { "x" : 739, "y" : 766 }, "minX" : 688, "maxX" : 790, "minY" : 760, "maxY" : 772, "segments" : [ { "from" : { "x" : 688, "y" : 766 }, "to" : { "x" : 790, "y" : 766 } } ], "endShape" : { "a" : { "x" : 783, "y" : 770 }, "b" : { "x" : 790, "y" : 766 }, "c" : { "x" : 783, "y" : 762 }, "type" : "ARROW", "centre" : { "x" : 783, "y" : 762 } }, "reactionShape" : { "a" : { "x" : 733, "y" : 760 }, "b" : { "x" : 745, "y" : 772 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 739, "y" : 766 } }, "inputs" : [ { "id" : 21041 } ], "outputs" : [ { "id" : 21038 } ] }, { "id" : 21059, "renderableClass" : "Interaction", "position" : { "x" : 643, "y" : 504 }, "minX" : 637, "maxX" : 649, "minY" : 483, "maxY" : 525, "interactionType" : "Activate", "segments" : [ { "from" : { "x" : 643, "y" : 525 }, "to" : { "x" : 643, "y" : 483 } } ], "endShape" : { "a" : { "x" : 647, "y" : 490 }, "b" : { "x" : 643, "y" : 483 }, "c" : { "x" : 639, "y" : 490 }, "type" : "ARROW", "empty" : true, "centre" : { "x" : 639, "y" : 490 } }, "reactionShape" : { "a" : { "x" : 637, "y" : 498 }, "b" : { "x" : 649, "y" : 510 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 643, "y" : 504 } }, "inputs" : [ { "id" : 21053 } ], "outputs" : [ { "id" : 21052 } ] }, { "id" : 21054, "renderableClass" : "Interaction", "position" : { "x" : 860, "y" : 695 }, "minX" : 854, "maxX" : 866, "minY" : 669, "maxY" : 722, "interactionType" : "Activate", "segments" : [ { "from" : { "x" : 860, "y" : 669 }, "to" : { "x" : 860, "y" : 722 } } ], "endShape" : { "a" : { "x" : 856, "y" : 715 }, "b" : { "x" : 860, "y" : 722 }, "c" : { "x" : 864, "y" : 715 }, "type" : "ARROW", "empty" : true, "centre" : { "x" : 864, "y" : 715 } }, "reactionShape" : { "a" : { "x" : 854, "y" : 689 }, "b" : { "x" : 866, "y" : 701 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 860, "y" : 695 } }, "inputs" : [ { "id" : 21026 } ], "outputs" : [ { "id" : 21038 } ] } ], "shadows" : [ { "id" : 21060, "reactomeId" : 10329421, "displayName" : "JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1", "schemaClass" : "Pathway", "renderableClass" : "Shadow", "position" : { "x" : 1051, "y" : 349 }, "minX" : 796, "maxX" : 1306, "minY" : 25, "maxY" : 673, "prop" : { "x" : 796, "y" : 26, "width" : 347, "height" : 577 }, "points" : [ { "x" : 796, "y" : 25 }, { "x" : 1306, "y" : 25 }, { "x" : 1306, "y" : 673 }, { "x" : 796, "y" : 673 } ], "colour" : "#4684ee" }, { "id" : 21061, "reactomeId" : 10330449, "displayName" : "activated TAK1 mediates p38 MAPK activation", "schemaClass" : "Pathway", "renderableClass" : "Shadow", "position" : { "x" : 1292, "y" : 314 }, "minX" : 1143, "maxX" : 1441, "minY" : 26, "maxY" : 603, "prop" : { "x" : 1306, "y" : 26, "width" : 135, "height" : 577 }, "points" : [ { "x" : 1143, "y" : 26 }, { "x" : 1441, "y" : 26 }, { "x" : 1441, "y" : 603 }, { "x" : 1143, "y" : 603 } ], "colour" : "#dc3912" } ], "minX" : 0, "maxX" : 1864, "minY" : 0, "maxY" : 948, "disease" : false }