{
  "dbId" : 10329365,
  "stableId" : "R-CFA-166658",
  "displayName" : "Complement cascade",
  "nodes" : [ {
    "id" : 59136,
    "reactomeId" : 10238109,
    "displayName" : "CFB",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 3216,
      "y" : 283
    },
    "minX" : 2766,
    "maxX" : 4071,
    "minY" : 165,
    "maxY" : 1073,
    "prop" : {
      "x" : 3170,
      "y" : 272,
      "width" : 93,
      "height" : 23
    },
    "textPosition" : {
      "x" : 3201,
      "y" : 273
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 3263,
          "y" : 272
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 3263,
          "y" : 272
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 59155,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 3209,
          "y" : 298
        },
        "to" : {
          "x" : 2766,
          "y" : 1073
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 3209,
          "y" : 306
        },
        "b" : {
          "x" : 3209,
          "y" : 298
        },
        "c" : {
          "x" : 3202,
          "y" : 302
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 3202,
          "y" : 302
        }
      }
    }, {
      "edgeId" : 59171,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 3266,
          "y" : 273
        },
        "to" : {
          "x" : 3412,
          "y" : 244
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 3272,
          "y" : 268
        },
        "b" : {
          "x" : 3266,
          "y" : 273
        },
        "c" : {
          "x" : 3274,
          "y" : 276
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 3274,
          "y" : 276
        }
      }
    }, {
      "edgeId" : 59185,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 3224,
          "y" : 269
        },
        "to" : {
          "x" : 3294,
          "y" : 172
        }
      }, {
        "from" : {
          "x" : 3294,
          "y" : 172
        },
        "to" : {
          "x" : 4036,
          "y" : 165
        }
      }, {
        "from" : {
          "x" : 4036,
          "y" : 165
        },
        "to" : {
          "x" : 4071,
          "y" : 230
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 3225,
          "y" : 261
        },
        "b" : {
          "x" : 3224,
          "y" : 269
        },
        "c" : {
          "x" : 3231,
          "y" : 266
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 3231,
          "y" : 266
        }
      }
    }, {
      "edgeId" : 59134,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 3167,
          "y" : 274
        },
        "to" : {
          "x" : 2911,
          "y" : 228
        }
      } ],
      "stoichiometry" : {
        "value" : 3,
        "shape" : {
          "a" : {
            "x" : 3033,
            "y" : 245
          },
          "b" : {
            "x" : 3045,
            "y" : 257
          },
          "type" : "BOX",
          "empty" : true,
          "centre" : {
            "x" : 3039,
            "y" : 251
          }
        }
      },
      "endShape" : {
        "a" : {
          "x" : 3159,
          "y" : 277
        },
        "b" : {
          "x" : 3167,
          "y" : 274
        },
        "c" : {
          "x" : 3161,
          "y" : 269
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 3161,
          "y" : 269
        }
      }
    } ]
  }, {
    "id" : 59137,
    "reactomeId" : 10238061,
    "displayName" : "C2",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 2947,
      "y" : 183
    },
    "minX" : 2911,
    "maxX" : 2969,
    "minY" : 166,
    "maxY" : 228,
    "prop" : {
      "x" : 2931,
      "y" : 172,
      "width" : 32,
      "height" : 23
    },
    "textPosition" : {
      "x" : 2935,
      "y" : 173
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 2963,
          "y" : 172
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 2963,
          "y" : 172
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 59134,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 2937,
          "y" : 198
        },
        "to" : {
          "x" : 2911,
          "y" : 228
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 2935,
          "y" : 206
        },
        "b" : {
          "x" : 2937,
          "y" : 198
        },
        "c" : {
          "x" : 2929,
          "y" : 201
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 2929,
          "y" : 201
        }
      }
    } ]
  }, {
    "id" : 59138,
    "reactomeId" : 10238081,
    "displayName" : "Cell surface:C4b",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 3088,
      "y" : 289
    },
    "minX" : 2911,
    "maxX" : 3146,
    "minY" : 228,
    "maxY" : 301,
    "prop" : {
      "x" : 3036,
      "y" : 278,
      "width" : 104,
      "height" : 23
    },
    "textPosition" : {
      "x" : 3045,
      "y" : 266
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 3140,
          "y" : 278
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 3140,
          "y" : 278
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 59134,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 3054,
          "y" : 275
        },
        "to" : {
          "x" : 2911,
          "y" : 228
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 3046,
          "y" : 277
        },
        "b" : {
          "x" : 3054,
          "y" : 275
        },
        "c" : {
          "x" : 3049,
          "y" : 269
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 3049,
          "y" : 269
        }
      }
    } ]
  }, {
    "id" : 59139,
    "reactomeId" : 10238083,
    "displayName" : "Cell surface:C4b:C2a",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 2928,
      "y" : 288
    },
    "minX" : 2863,
    "maxX" : 3000,
    "minY" : 228,
    "maxY" : 300,
    "prop" : {
      "x" : 2863,
      "y" : 277,
      "width" : 131,
      "height" : 23
    },
    "textPosition" : {
      "x" : 2872,
      "y" : 265
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 2994,
          "y" : 277
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 2994,
          "y" : 277
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 59134,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 2924,
          "y" : 274
        },
        "to" : {
          "x" : 2911,
          "y" : 228
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 2918,
          "y" : 268
        },
        "b" : {
          "x" : 2924,
          "y" : 274
        },
        "c" : {
          "x" : 2926,
          "y" : 266
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 2926,
          "y" : 266
        }
      }
    } ]
  }, {
    "id" : 59140,
    "reactomeId" : 10238105,
    "displayName" : "C3(H2O)",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 3018,
      "y" : 182
    },
    "minX" : 2911,
    "maxX" : 3054,
    "minY" : 165,
    "maxY" : 228,
    "prop" : {
      "x" : 2989,
      "y" : 171,
      "width" : 59,
      "height" : 23
    },
    "textPosition" : {
      "x" : 2996,
      "y" : 159
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 3048,
          "y" : 171
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 3048,
          "y" : 171
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 59134,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 2991,
          "y" : 197
        },
        "to" : {
          "x" : 2911,
          "y" : 228
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 2986,
          "y" : 203
        },
        "b" : {
          "x" : 2991,
          "y" : 197
        },
        "c" : {
          "x" : 2983,
          "y" : 196
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 2983,
          "y" : 196
        }
      }
    } ]
  }, {
    "id" : 59141,
    "reactomeId" : 10238098,
    "displayName" : "C3b",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 3140,
      "y" : 226
    },
    "minX" : 2911,
    "maxX" : 3163,
    "minY" : 209,
    "maxY" : 238,
    "prop" : {
      "x" : 3124,
      "y" : 215,
      "width" : 33,
      "height" : 23
    },
    "textPosition" : {
      "x" : 3124,
      "y" : 217
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 3157,
          "y" : 215
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 3157,
          "y" : 215
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 59134,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 3121,
          "y" : 226
        },
        "to" : {
          "x" : 2911,
          "y" : 228
        }
      } ],
      "stoichiometry" : {
        "value" : 3,
        "shape" : {
          "a" : {
            "x" : 3010,
            "y" : 221
          },
          "b" : {
            "x" : 3022,
            "y" : 233
          },
          "type" : "BOX",
          "empty" : true,
          "centre" : {
            "x" : 3016,
            "y" : 227
          }
        }
      },
      "endShape" : {
        "a" : {
          "x" : 3114,
          "y" : 230
        },
        "b" : {
          "x" : 3121,
          "y" : 226
        },
        "c" : {
          "x" : 3114,
          "y" : 222
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 3114,
          "y" : 222
        }
      }
    } ]
  }, {
    "id" : 59142,
    "reactomeId" : 10238121,
    "displayName" : "Properdin oligomer",
    "schemaClass" : "Polymer",
    "renderableClass" : "Entity",
    "position" : {
      "x" : 3142,
      "y" : 182
    },
    "minX" : 2911,
    "maxX" : 3202,
    "minY" : 171,
    "maxY" : 228,
    "prop" : {
      "x" : 3082,
      "y" : 171,
      "width" : 120,
      "height" : 23
    },
    "textPosition" : {
      "x" : 3105,
      "y" : 165
    },
    "connectors" : [ {
      "edgeId" : 59134,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 3079,
          "y" : 193
        },
        "to" : {
          "x" : 2911,
          "y" : 228
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 3073,
          "y" : 198
        },
        "b" : {
          "x" : 3079,
          "y" : 193
        },
        "c" : {
          "x" : 3071,
          "y" : 190
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 3071,
          "y" : 190
        }
      }
    } ]
  }, {
    "id" : 59144,
    "reactomeId" : 10238098,
    "displayName" : "C3b",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 3194,
      "y" : 1201
    },
    "minX" : 3178,
    "maxX" : 3229,
    "minY" : 1175,
    "maxY" : 1213,
    "prop" : {
      "x" : 3178,
      "y" : 1190,
      "width" : 33,
      "height" : 23
    },
    "textPosition" : {
      "x" : 3178,
      "y" : 1192
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 3211,
          "y" : 1190
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 3211,
          "y" : 1190
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 59143,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 3209,
          "y" : 1187
        },
        "to" : {
          "x" : 3229,
          "y" : 1175
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 59145,
    "reactomeId" : 10263070,
    "displayName" : "CFH",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 3178,
      "y" : 1154
    },
    "minX" : 3131,
    "maxX" : 3231,
    "minY" : 1135,
    "maxY" : 1249,
    "prop" : {
      "x" : 3162,
      "y" : 1143,
      "width" : 32,
      "height" : 23
    },
    "textPosition" : {
      "x" : 3162,
      "y" : 1144
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 3194,
          "y" : 1143
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 3194,
          "y" : 1143
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 59143,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 3197,
          "y" : 1160
        },
        "to" : {
          "x" : 3229,
          "y" : 1175
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 59203,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 3197,
          "y" : 1148
        },
        "to" : {
          "x" : 3231,
          "y" : 1135
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 59218,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 3172,
          "y" : 1169
        },
        "to" : {
          "x" : 3131,
          "y" : 1249
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 3172,
          "y" : 1177
        },
        "b" : {
          "x" : 3172,
          "y" : 1169
        },
        "c" : {
          "x" : 3165,
          "y" : 1173
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 3165,
          "y" : 1173
        }
      }
    } ]
  }, {
    "id" : 59146,
    "reactomeId" : 10263072,
    "displayName" : "CFH:C3b",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 3338,
      "y" : 1176
    },
    "minX" : 3308,
    "maxX" : 3374,
    "minY" : 1159,
    "maxY" : 1251,
    "prop" : {
      "x" : 3308,
      "y" : 1165,
      "width" : 60,
      "height" : 23
    },
    "textPosition" : {
      "x" : 3308,
      "y" : 1167
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 3368,
          "y" : 1165
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 3368,
          "y" : 1165
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 59143,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 59160,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 3341,
          "y" : 1191
        },
        "to" : {
          "x" : 3362,
          "y" : 1251
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 59148,
    "reactomeId" : 10263219,
    "displayName" : "CFH, CFHR3",
    "schemaClass" : "CandidateSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 2638,
      "y" : 808
    },
    "minX" : 2599,
    "maxX" : 2804,
    "minY" : 797,
    "maxY" : 898,
    "prop" : {
      "x" : 2599,
      "y" : 797,
      "width" : 79,
      "height" : 23
    },
    "textPosition" : {
      "x" : 2614,
      "y" : 791
    },
    "connectors" : [ {
      "edgeId" : 59147,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 2684,
          "y" : 811
        },
        "to" : {
          "x" : 2804,
          "y" : 824
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 59152,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 2645,
          "y" : 826
        },
        "to" : {
          "x" : 2699,
          "y" : 898
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 59149,
    "reactomeId" : 10238125,
    "displayName" : "Cell surface:C3b",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 2736,
      "y" : 769
    },
    "minX" : 2684,
    "maxX" : 2804,
    "minY" : 752,
    "maxY" : 824,
    "prop" : {
      "x" : 2684,
      "y" : 758,
      "width" : 104,
      "height" : 23
    },
    "textPosition" : {
      "x" : 2693,
      "y" : 746
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 2788,
          "y" : 758
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 2788,
          "y" : 758
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 59147,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 2750,
          "y" : 784
        },
        "to" : {
          "x" : 2804,
          "y" : 824
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 59150,
    "reactomeId" : 10263221,
    "displayName" : "Cell surface:FH,FHR3:C3b",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 2776,
      "y" : 1114
    },
    "minX" : 2727,
    "maxX" : 2832,
    "minY" : 1073,
    "maxY" : 1148,
    "prop" : {
      "x" : 2727,
      "y" : 1096,
      "width" : 99,
      "height" : 37
    },
    "textPosition" : {
      "x" : 2732,
      "y" : 1098
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 2826,
          "y" : 1096
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 2826,
          "y" : 1096
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 59147,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 59155,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 2771,
          "y" : 1093
        },
        "to" : {
          "x" : 2766,
          "y" : 1073
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 2765,
          "y" : 1087
        },
        "b" : {
          "x" : 2771,
          "y" : 1093
        },
        "c" : {
          "x" : 2773,
          "y" : 1085
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 2773,
          "y" : 1085
        }
      }
    }, {
      "edgeId" : 59162,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 2804,
          "y" : 1136
        },
        "to" : {
          "x" : 2828,
          "y" : 1148
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 59151,
    "reactomeId" : 10263229,
    "displayName" : "CFH:Host cell surface",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 3328,
      "y" : 1101
    },
    "minX" : 2706,
    "maxX" : 3400,
    "minY" : 941,
    "maxY" : 1113,
    "prop" : {
      "x" : 3263,
      "y" : 1090,
      "width" : 131,
      "height" : 23
    },
    "textPosition" : {
      "x" : 3281,
      "y" : 1078
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 3394,
          "y" : 1090
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 3394,
          "y" : 1090
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 59147,
      "type" : "ACTIVATOR",
      "segments" : [ {
        "from" : {
          "x" : 3290,
          "y" : 1087
        },
        "to" : {
          "x" : 2815,
          "y" : 945
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 2823,
          "y" : 943
        },
        "b" : {
          "x" : 2815,
          "y" : 945
        },
        "c" : {
          "x" : 2820,
          "y" : 951
        },
        "type" : "ARROW",
        "empty" : true,
        "centre" : {
          "x" : 2820,
          "y" : 951
        }
      }
    }, {
      "edgeId" : 59152,
      "type" : "ACTIVATOR",
      "segments" : [ {
        "from" : {
          "x" : 3282,
          "y" : 1087
        },
        "to" : {
          "x" : 2706,
          "y" : 943
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 2714,
          "y" : 941
        },
        "b" : {
          "x" : 2706,
          "y" : 943
        },
        "c" : {
          "x" : 2712,
          "y" : 949
        },
        "type" : "ARROW",
        "empty" : true,
        "centre" : {
          "x" : 2712,
          "y" : 949
        }
      }
    }, {
      "edgeId" : 59203,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 59153,
    "reactomeId" : 10238115,
    "displayName" : "Cell surface:C3b:Bb",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 2734,
      "y" : 855
    },
    "minX" : 2673,
    "maxX" : 2802,
    "minY" : 838,
    "maxY" : 898,
    "prop" : {
      "x" : 2673,
      "y" : 844,
      "width" : 123,
      "height" : 23
    },
    "textPosition" : {
      "x" : 2678,
      "y" : 832
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 2796,
          "y" : 844
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 2796,
          "y" : 844
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 59152,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 2724,
          "y" : 870
        },
        "to" : {
          "x" : 2699,
          "y" : 898
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 59154,
    "reactomeId" : 10263227,
    "displayName" : "Cell surface:CFH, CFHR3:C3bBb",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 2726,
      "y" : 1005
    },
    "minX" : 2671,
    "maxX" : 2788,
    "minY" : 981,
    "maxY" : 1024,
    "prop" : {
      "x" : 2671,
      "y" : 987,
      "width" : 111,
      "height" : 37
    },
    "textPosition" : {
      "x" : 2684,
      "y" : 975
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 2782,
          "y" : 987
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 2782,
          "y" : 987
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 59152,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 59155,
      "type" : "INPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 59157,
    "reactomeId" : 10263076,
    "displayName" : "CFI",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 3837,
      "y" : 1336
    },
    "minX" : 3744,
    "maxX" : 3884,
    "minY" : 1319,
    "maxY" : 1363,
    "prop" : {
      "x" : 3797,
      "y" : 1325,
      "width" : 81,
      "height" : 23
    },
    "textPosition" : {
      "x" : 3824,
      "y" : 1326
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 3878,
          "y" : 1325
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 3878,
          "y" : 1325
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 59156,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 3794,
          "y" : 1347
        },
        "to" : {
          "x" : 3744,
          "y" : 1363
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 59158,
    "reactomeId" : 10263078,
    "displayName" : "CFI",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 3833,
      "y" : 1384
    },
    "minX" : 3744,
    "maxX" : 3884,
    "minY" : 1363,
    "maxY" : 1396,
    "prop" : {
      "x" : 3789,
      "y" : 1373,
      "width" : 89,
      "height" : 23
    },
    "textPosition" : {
      "x" : 3820,
      "y" : 1374
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 3878,
          "y" : 1373
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 3878,
          "y" : 1373
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 59156,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 3786,
          "y" : 1373
        },
        "to" : {
          "x" : 3744,
          "y" : 1363
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 59159,
    "reactomeId" : 10263080,
    "displayName" : "CFI",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 3518,
      "y" : 1361
    },
    "minX" : 2828,
    "maxX" : 4552,
    "minY" : 1118,
    "maxY" : 1373,
    "prop" : {
      "x" : 3505,
      "y" : 1350,
      "width" : 26,
      "height" : 23
    },
    "textPosition" : {
      "x" : 3505,
      "y" : 1352
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 3531,
          "y" : 1350
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 3531,
          "y" : 1350
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 59156,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 59160,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 3502,
          "y" : 1351
        },
        "to" : {
          "x" : 3362,
          "y" : 1251
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 59162,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 3502,
          "y" : 1361
        },
        "to" : {
          "x" : 2938,
          "y" : 1361
        }
      }, {
        "from" : {
          "x" : 2938,
          "y" : 1361
        },
        "to" : {
          "x" : 2828,
          "y" : 1148
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 59175,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 3534,
          "y" : 1352
        },
        "to" : {
          "x" : 3818,
          "y" : 1154
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 59178,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 3534,
          "y" : 1355
        },
        "to" : {
          "x" : 4049,
          "y" : 1151
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 3539,
          "y" : 1349
        },
        "b" : {
          "x" : 3534,
          "y" : 1355
        },
        "c" : {
          "x" : 3542,
          "y" : 1356
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 3542,
          "y" : 1356
        }
      }
    }, {
      "edgeId" : 59193,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 3534,
          "y" : 1358
        },
        "to" : {
          "x" : 4456,
          "y" : 1157
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 59195,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 3534,
          "y" : 1358
        },
        "to" : {
          "x" : 4552,
          "y" : 1188
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 3540,
          "y" : 1353
        },
        "b" : {
          "x" : 3534,
          "y" : 1358
        },
        "c" : {
          "x" : 3541,
          "y" : 1361
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 3541,
          "y" : 1361
        }
      }
    }, {
      "edgeId" : 59218,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 3502,
          "y" : 1359
        },
        "to" : {
          "x" : 3141,
          "y" : 1324
        }
      }, {
        "from" : {
          "x" : 3141,
          "y" : 1324
        },
        "to" : {
          "x" : 3131,
          "y" : 1249
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 3495,
          "y" : 1362
        },
        "b" : {
          "x" : 3502,
          "y" : 1359
        },
        "c" : {
          "x" : 3495,
          "y" : 1354
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 3495,
          "y" : 1354
        }
      }
    }, {
      "edgeId" : 59220,
      "type" : "CATALYST",
      "segments" : [ {
        "from" : {
          "x" : 3518,
          "y" : 1347
        },
        "to" : {
          "x" : 3525,
          "y" : 1126
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 3525,
          "y" : 1122
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 3525,
          "y" : 1122
        }
      }
    } ]
  }, {
    "id" : 59161,
    "reactomeId" : 10263082,
    "displayName" : "CFI:CFH:C3b",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 3251,
      "y" : 1251
    },
    "minX" : 3155,
    "maxX" : 3298,
    "minY" : 1234,
    "maxY" : 1286,
    "prop" : {
      "x" : 3211,
      "y" : 1240,
      "width" : 81,
      "height" : 23
    },
    "textPosition" : {
      "x" : 3222,
      "y" : 1228
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 3292,
          "y" : 1240
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 3292,
          "y" : 1240
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 59160,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 59218,
      "type" : "INPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 59218,
      "type" : "CATALYST",
      "segments" : [ {
        "from" : {
          "x" : 3221,
          "y" : 1266
        },
        "to" : {
          "x" : 3162,
          "y" : 1286
        }
      }, {
        "from" : {
          "x" : 3162,
          "y" : 1286
        },
        "to" : {
          "x" : 3160,
          "y" : 1265
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 3159,
          "y" : 1261
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 3159,
          "y" : 1261
        }
      }
    } ]
  }, {
    "id" : 59163,
    "reactomeId" : 10263223,
    "displayName" : "CFI:CFH,FHR3:C3b",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 2906,
      "y" : 1105
    },
    "minX" : 2848,
    "maxX" : 2995,
    "minY" : 1088,
    "maxY" : 1141,
    "prop" : {
      "x" : 2848,
      "y" : 1094,
      "width" : 116,
      "height" : 23
    },
    "textPosition" : {
      "x" : 2859,
      "y" : 1082
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 2964,
          "y" : 1094
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 2964,
          "y" : 1094
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 59162,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 59164,
      "type" : "INPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 59164,
      "type" : "CATALYST",
      "segments" : [ {
        "from" : {
          "x" : 2933,
          "y" : 1120
        },
        "to" : {
          "x" : 2991,
          "y" : 1141
        }
      }, {
        "from" : {
          "x" : 2991,
          "y" : 1141
        },
        "to" : {
          "x" : 2991,
          "y" : 1122
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 2991,
          "y" : 1118
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 2991,
          "y" : 1118
        }
      }
    } ]
  }, {
    "id" : 59165,
    "reactomeId" : 10263246,
    "displayName" : "CFI:CFH,FHR3:iC3b",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 3088,
      "y" : 1105
    },
    "minX" : 3010,
    "maxX" : 3154,
    "minY" : 1088,
    "maxY" : 1117,
    "prop" : {
      "x" : 3029,
      "y" : 1094,
      "width" : 119,
      "height" : 23
    },
    "textPosition" : {
      "x" : 3041,
      "y" : 1082
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 3148,
          "y" : 1094
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 3148,
          "y" : 1094
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 59164,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 3026,
          "y" : 1105
        },
        "to" : {
          "x" : 3010,
          "y" : 1105
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 3019,
          "y" : 1109
        },
        "b" : {
          "x" : 3026,
          "y" : 1105
        },
        "c" : {
          "x" : 3019,
          "y" : 1101
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 3019,
          "y" : 1101
        }
      }
    } ]
  }, {
    "id" : 59166,
    "reactomeId" : 10263090,
    "displayName" : "C3",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 3069,
      "y" : 1164
    },
    "minX" : 3010,
    "maxX" : 3131,
    "minY" : 1105,
    "maxY" : 1249,
    "prop" : {
      "x" : 3055,
      "y" : 1153,
      "width" : 29,
      "height" : 23
    },
    "textPosition" : {
      "x" : 3057,
      "y" : 1154
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 3084,
          "y" : 1153
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 3084,
          "y" : 1153
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 59164,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 3057,
          "y" : 1150
        },
        "to" : {
          "x" : 3010,
          "y" : 1105
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 3049,
          "y" : 1148
        },
        "b" : {
          "x" : 3057,
          "y" : 1150
        },
        "c" : {
          "x" : 3055,
          "y" : 1142
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 3055,
          "y" : 1142
        }
      }
    }, {
      "edgeId" : 59218,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 3077,
          "y" : 1179
        },
        "to" : {
          "x" : 3131,
          "y" : 1249
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 3084,
          "y" : 1182
        },
        "b" : {
          "x" : 3077,
          "y" : 1179
        },
        "c" : {
          "x" : 3078,
          "y" : 1187
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 3078,
          "y" : 1187
        }
      }
    } ]
  }, {
    "id" : 59168,
    "reactomeId" : 10263253,
    "displayName" : "LOC490269",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 3666,
      "y" : 278
    },
    "minX" : 3545,
    "maxX" : 3689,
    "minY" : 238,
    "maxY" : 1110,
    "prop" : {
      "x" : 3650,
      "y" : 267,
      "width" : 33,
      "height" : 23
    },
    "textPosition" : {
      "x" : 3650,
      "y" : 254
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 3683,
          "y" : 267
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 3683,
          "y" : 267
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 59167,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 3672,
          "y" : 264
        },
        "to" : {
          "x" : 3688,
          "y" : 238
        }
      } ],
      "stoichiometry" : {
        "value" : 2,
        "shape" : {
          "a" : {
            "x" : 3674,
            "y" : 245
          },
          "b" : {
            "x" : 3686,
            "y" : 257
          },
          "type" : "BOX",
          "empty" : true,
          "centre" : {
            "x" : 3680,
            "y" : 251
          }
        }
      }
    }, {
      "edgeId" : 59220,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 3664,
          "y" : 293
        },
        "to" : {
          "x" : 3545,
          "y" : 1110
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 3667,
          "y" : 300
        },
        "b" : {
          "x" : 3664,
          "y" : 293
        },
        "c" : {
          "x" : 3659,
          "y" : 299
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 3659,
          "y" : 299
        }
      }
    } ]
  }, {
    "id" : 59169,
    "reactomeId" : 10263255,
    "displayName" : "C4bC2a, C3bBb",
    "schemaClass" : "DefinedSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 3758,
      "y" : 283
    },
    "minX" : 3688,
    "maxX" : 3876,
    "minY" : 231,
    "maxY" : 295,
    "prop" : {
      "x" : 3707,
      "y" : 272,
      "width" : 103,
      "height" : 23
    },
    "textPosition" : {
      "x" : 3726,
      "y" : 266
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "connectors" : [ {
      "edgeId" : 59167,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 3740,
          "y" : 266
        },
        "to" : {
          "x" : 3688,
          "y" : 238
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 59182,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 3784,
          "y" : 266
        },
        "to" : {
          "x" : 3876,
          "y" : 231
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 59170,
    "reactomeId" : 10263261,
    "displayName" : "CR1:C3bBb, C4bC2a complexes",
    "schemaClass" : "DefinedSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 3557,
      "y" : 282
    },
    "minX" : 3490,
    "maxX" : 3625,
    "minY" : 264,
    "maxY" : 301,
    "prop" : {
      "x" : 3490,
      "y" : 264,
      "width" : 135,
      "height" : 37
    },
    "textPosition" : {
      "x" : 3490,
      "y" : 265
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "connectors" : [ {
      "edgeId" : 59167,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 59171,
      "type" : "INPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 59172,
    "reactomeId" : 10263273,
    "displayName" : "CR1:C3b",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 3437,
      "y" : 282
    },
    "minX" : 3407,
    "maxX" : 3474,
    "minY" : 244,
    "maxY" : 294,
    "prop" : {
      "x" : 3407,
      "y" : 271,
      "width" : 61,
      "height" : 23
    },
    "textPosition" : {
      "x" : 3407,
      "y" : 273
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 3468,
          "y" : 271
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 3468,
          "y" : 271
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 59171,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 3429,
          "y" : 268
        },
        "to" : {
          "x" : 3412,
          "y" : 244
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 3422,
          "y" : 265
        },
        "b" : {
          "x" : 3429,
          "y" : 268
        },
        "c" : {
          "x" : 3428,
          "y" : 260
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 3428,
          "y" : 260
        }
      }
    } ]
  }, {
    "id" : 59173,
    "reactomeId" : 10263275,
    "displayName" : "CR1:C4b",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 3348,
      "y" : 282
    },
    "minX" : 3318,
    "maxX" : 3412,
    "minY" : 244,
    "maxY" : 294,
    "prop" : {
      "x" : 3318,
      "y" : 271,
      "width" : 61,
      "height" : 23
    },
    "textPosition" : {
      "x" : 3318,
      "y" : 273
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 3379,
          "y" : 271
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 3379,
          "y" : 271
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 59171,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 3367,
          "y" : 268
        },
        "to" : {
          "x" : 3412,
          "y" : 244
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 3371,
          "y" : 261
        },
        "b" : {
          "x" : 3367,
          "y" : 268
        },
        "c" : {
          "x" : 3375,
          "y" : 268
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 3375,
          "y" : 268
        }
      }
    } ]
  }, {
    "id" : 59174,
    "reactomeId" : 10238061,
    "displayName" : "C2",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 3370,
      "y" : 223
    },
    "minX" : 3354,
    "maxX" : 3412,
    "minY" : 206,
    "maxY" : 244,
    "prop" : {
      "x" : 3354,
      "y" : 212,
      "width" : 32,
      "height" : 23
    },
    "textPosition" : {
      "x" : 3358,
      "y" : 213
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 3386,
          "y" : 212
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 3386,
          "y" : 212
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 59171,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 3389,
          "y" : 231
        },
        "to" : {
          "x" : 3412,
          "y" : 244
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 3397,
          "y" : 231
        },
        "b" : {
          "x" : 3389,
          "y" : 231
        },
        "c" : {
          "x" : 3393,
          "y" : 238
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 3393,
          "y" : 238
        }
      }
    } ]
  }, {
    "id" : 59176,
    "reactomeId" : 10263277,
    "displayName" : "CD46, CR1:C4b:C3b complexes",
    "schemaClass" : "DefinedSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 3760,
      "y" : 1107
    },
    "minX" : 3693,
    "maxX" : 3827,
    "minY" : 1089,
    "maxY" : 1154,
    "prop" : {
      "x" : 3693,
      "y" : 1089,
      "width" : 134,
      "height" : 37
    },
    "textPosition" : {
      "x" : 3693,
      "y" : 1090
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "connectors" : [ {
      "edgeId" : 59175,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 3782,
          "y" : 1132
        },
        "to" : {
          "x" : 3818,
          "y" : 1154
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 59177,
    "reactomeId" : 10263279,
    "displayName" : "CFI:CD46, CR1:C4b, C3b complexes",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 3911,
      "y" : 1107
    },
    "minX" : 3846,
    "maxX" : 4006,
    "minY" : 1083,
    "maxY" : 1133,
    "prop" : {
      "x" : 3846,
      "y" : 1089,
      "width" : 131,
      "height" : 37
    },
    "textPosition" : {
      "x" : 3846,
      "y" : 1091
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 3977,
          "y" : 1089
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 3977,
          "y" : 1089
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 59175,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 59178,
      "type" : "INPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 59178,
      "type" : "CATALYST",
      "segments" : [ {
        "from" : {
          "x" : 3980,
          "y" : 1104
        },
        "to" : {
          "x" : 4003,
          "y" : 1104
        }
      }, {
        "from" : {
          "x" : 4003,
          "y" : 1104
        },
        "to" : {
          "x" : 4002,
          "y" : 1125
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 4002,
          "y" : 1129
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 4002,
          "y" : 1129
        }
      }
    } ]
  }, {
    "id" : 59179,
    "reactomeId" : 10263287,
    "displayName" : "C4d, iC3b",
    "schemaClass" : "DefinedSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 4057,
      "y" : 1104
    },
    "minX" : 4023,
    "maxX" : 4091,
    "minY" : 1093,
    "maxY" : 1151,
    "prop" : {
      "x" : 4023,
      "y" : 1093,
      "width" : 68,
      "height" : 23
    },
    "textPosition" : {
      "x" : 4023,
      "y" : 1094
    },
    "connectors" : [ {
      "edgeId" : 59178,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 4055,
          "y" : 1122
        },
        "to" : {
          "x" : 4049,
          "y" : 1151
        }
      } ],
      "stoichiometry" : {
        "value" : 2,
        "shape" : {
          "a" : {
            "x" : 4046,
            "y" : 1130
          },
          "b" : {
            "x" : 4058,
            "y" : 1142
          },
          "type" : "BOX",
          "empty" : true,
          "centre" : {
            "x" : 4052,
            "y" : 1136
          }
        }
      },
      "endShape" : {
        "a" : {
          "x" : 4058,
          "y" : 1130
        },
        "b" : {
          "x" : 4055,
          "y" : 1122
        },
        "c" : {
          "x" : 4050,
          "y" : 1128
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 4050,
          "y" : 1128
        }
      }
    } ]
  }, {
    "id" : 59180,
    "reactomeId" : 10263297,
    "displayName" : "C4c, C3f",
    "schemaClass" : "DefinedSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 4129,
      "y" : 1183
    },
    "minX" : 4049,
    "maxX" : 4159,
    "minY" : 1151,
    "maxY" : 1195,
    "prop" : {
      "x" : 4100,
      "y" : 1172,
      "width" : 59,
      "height" : 23
    },
    "textPosition" : {
      "x" : 4100,
      "y" : 1173
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "connectors" : [ {
      "edgeId" : 59178,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 4100,
          "y" : 1166
        },
        "to" : {
          "x" : 4049,
          "y" : 1151
        }
      } ],
      "stoichiometry" : {
        "value" : 2,
        "shape" : {
          "a" : {
            "x" : 4068,
            "y" : 1152
          },
          "b" : {
            "x" : 4080,
            "y" : 1164
          },
          "type" : "BOX",
          "empty" : true,
          "centre" : {
            "x" : 4074,
            "y" : 1158
          }
        }
      },
      "endShape" : {
        "a" : {
          "x" : 4092,
          "y" : 1168
        },
        "b" : {
          "x" : 4100,
          "y" : 1166
        },
        "c" : {
          "x" : 4094,
          "y" : 1160
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 4094,
          "y" : 1160
        }
      }
    } ]
  }, {
    "id" : 59181,
    "reactomeId" : 10263289,
    "displayName" : "CD46, CR1",
    "schemaClass" : "DefinedSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 4169,
      "y" : 1104
    },
    "minX" : 4049,
    "maxX" : 4206,
    "minY" : 1093,
    "maxY" : 1151,
    "prop" : {
      "x" : 4132,
      "y" : 1093,
      "width" : 74,
      "height" : 23
    },
    "textPosition" : {
      "x" : 4132,
      "y" : 1094
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 204
    },
    "fgColor" : {
      "r" : 0,
      "g" : 0,
      "b" : 0
    },
    "connectors" : [ {
      "edgeId" : 59178,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 4139,
          "y" : 1122
        },
        "to" : {
          "x" : 4049,
          "y" : 1151
        }
      } ],
      "stoichiometry" : {
        "value" : 2,
        "shape" : {
          "a" : {
            "x" : 4088,
            "y" : 1130
          },
          "b" : {
            "x" : 4100,
            "y" : 1142
          },
          "type" : "BOX",
          "empty" : true,
          "centre" : {
            "x" : 4094,
            "y" : 1136
          }
        }
      },
      "endShape" : {
        "a" : {
          "x" : 4134,
          "y" : 1128
        },
        "b" : {
          "x" : 4139,
          "y" : 1122
        },
        "c" : {
          "x" : 4131,
          "y" : 1120
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 4131,
          "y" : 1120
        }
      }
    } ]
  }, {
    "id" : 59183,
    "reactomeId" : 10263302,
    "displayName" : "CD55",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 3852,
      "y" : 279
    },
    "minX" : 3831,
    "maxX" : 3879,
    "minY" : 231,
    "maxY" : 291,
    "prop" : {
      "x" : 3831,
      "y" : 268,
      "width" : 42,
      "height" : 23
    },
    "textPosition" : {
      "x" : 3831,
      "y" : 269
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 3873,
          "y" : 268
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 3873,
          "y" : 268
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 59182,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 3857,
          "y" : 265
        },
        "to" : {
          "x" : 3876,
          "y" : 231
        }
      } ],
      "stoichiometry" : {
        "value" : 2,
        "shape" : {
          "a" : {
            "x" : 3860,
            "y" : 242
          },
          "b" : {
            "x" : 3872,
            "y" : 254
          },
          "type" : "BOX",
          "empty" : true,
          "centre" : {
            "x" : 3866,
            "y" : 248
          }
        }
      }
    } ]
  }, {
    "id" : 59184,
    "reactomeId" : 10263308,
    "displayName" : "CD55:C3 convertase complexes",
    "schemaClass" : "DefinedSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 3962,
      "y" : 284
    },
    "minX" : 3896,
    "maxX" : 4028,
    "minY" : 266,
    "maxY" : 303,
    "prop" : {
      "x" : 3896,
      "y" : 266,
      "width" : 132,
      "height" : 37
    },
    "textPosition" : {
      "x" : 3921,
      "y" : 260
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "connectors" : [ {
      "edgeId" : 59182,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 59185,
      "type" : "INPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 59186,
    "reactomeId" : 10263310,
    "displayName" : "CD55:C3b",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 4163,
      "y" : 279
    },
    "minX" : 4071,
    "maxX" : 4204,
    "minY" : 230,
    "maxY" : 291,
    "prop" : {
      "x" : 4128,
      "y" : 268,
      "width" : 70,
      "height" : 23
    },
    "textPosition" : {
      "x" : 4128,
      "y" : 270
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 4198,
          "y" : 268
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 4198,
          "y" : 268
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 59185,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 4141,
          "y" : 265
        },
        "to" : {
          "x" : 4071,
          "y" : 230
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 4133,
          "y" : 265
        },
        "b" : {
          "x" : 4141,
          "y" : 265
        },
        "c" : {
          "x" : 4137,
          "y" : 258
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 4137,
          "y" : 258
        }
      }
    } ]
  }, {
    "id" : 59187,
    "reactomeId" : 10263312,
    "displayName" : "CD55:C4b",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 4078,
      "y" : 280
    },
    "minX" : 4043,
    "maxX" : 4119,
    "minY" : 230,
    "maxY" : 292,
    "prop" : {
      "x" : 4043,
      "y" : 269,
      "width" : 70,
      "height" : 23
    },
    "textPosition" : {
      "x" : 4043,
      "y" : 271
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 4113,
          "y" : 269
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 4113,
          "y" : 269
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 59185,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 4076,
          "y" : 266
        },
        "to" : {
          "x" : 4071,
          "y" : 230
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 4071,
          "y" : 260
        },
        "b" : {
          "x" : 4076,
          "y" : 266
        },
        "c" : {
          "x" : 4079,
          "y" : 259
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 4079,
          "y" : 259
        }
      }
    } ]
  }, {
    "id" : 59188,
    "reactomeId" : 10238061,
    "displayName" : "C2",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 4117,
      "y" : 206
    },
    "minX" : 4071,
    "maxX" : 4139,
    "minY" : 189,
    "maxY" : 230,
    "prop" : {
      "x" : 4101,
      "y" : 195,
      "width" : 32,
      "height" : 23
    },
    "textPosition" : {
      "x" : 4105,
      "y" : 196
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 4133,
          "y" : 195
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 4133,
          "y" : 195
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 59185,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 4098,
          "y" : 214
        },
        "to" : {
          "x" : 4071,
          "y" : 230
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 4094,
          "y" : 221
        },
        "b" : {
          "x" : 4098,
          "y" : 214
        },
        "c" : {
          "x" : 4090,
          "y" : 214
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 4090,
          "y" : 214
        }
      }
    } ]
  }, {
    "id" : 59190,
    "reactomeId" : 10263330,
    "displayName" : "C4b-binding protein",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 4561,
      "y" : 766
    },
    "minX" : 4497,
    "maxX" : 4825,
    "minY" : 715,
    "maxY" : 1188,
    "prop" : {
      "x" : 4497,
      "y" : 755,
      "width" : 128,
      "height" : 23
    },
    "textPosition" : {
      "x" : 4518,
      "y" : 743
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 4625,
          "y" : 755
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 4625,
          "y" : 755
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 59189,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 4570,
          "y" : 781
        },
        "to" : {
          "x" : 4642,
          "y" : 866
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 59195,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 4628,
          "y" : 765
        },
        "to" : {
          "x" : 4825,
          "y" : 763
        }
      }, {
        "from" : {
          "x" : 4825,
          "y" : 763
        },
        "to" : {
          "x" : 4823,
          "y" : 1099
        }
      }, {
        "from" : {
          "x" : 4823,
          "y" : 1099
        },
        "to" : {
          "x" : 4552,
          "y" : 1188
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 4635,
          "y" : 761
        },
        "b" : {
          "x" : 4628,
          "y" : 765
        },
        "c" : {
          "x" : 4635,
          "y" : 769
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 4635,
          "y" : 769
        }
      }
    }, {
      "edgeId" : 59198,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 4568,
          "y" : 781
        },
        "to" : {
          "x" : 4617,
          "y" : 856
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 59205,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 4570,
          "y" : 752
        },
        "to" : {
          "x" : 4602,
          "y" : 715
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 59191,
    "reactomeId" : 10263335,
    "displayName" : "C4A(20-675):C4A(1454-1744):S-(L-isoglutamyl)-L-cysteine-C4A(757-1446)",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 4672,
      "y" : 805
    },
    "minX" : 4642,
    "maxX" : 4726,
    "minY" : 788,
    "maxY" : 866,
    "prop" : {
      "x" : 4656,
      "y" : 794,
      "width" : 33,
      "height" : 23
    },
    "textPosition" : {
      "x" : 4656,
      "y" : 641
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 4689,
          "y" : 794
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 4689,
          "y" : 794
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 59189,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 4666,
          "y" : 823
        },
        "to" : {
          "x" : 4642,
          "y" : 866
        }
      } ],
      "stoichiometry" : {
        "value" : 7,
        "shape" : {
          "a" : {
            "x" : 4648,
            "y" : 838
          },
          "b" : {
            "x" : 4660,
            "y" : 850
          },
          "type" : "BOX",
          "empty" : true,
          "centre" : {
            "x" : 4654,
            "y" : 844
          }
        }
      }
    }, {
      "edgeId" : 59234,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 4684,
          "y" : 823
        },
        "to" : {
          "x" : 4726,
          "y" : 856
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 59192,
    "reactomeId" : 10263337,
    "displayName" : "C4-binding protein:C4b",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 4291,
      "y" : 1107
    },
    "minX" : 4229,
    "maxX" : 4536,
    "minY" : 1021,
    "maxY" : 1157,
    "prop" : {
      "x" : 4229,
      "y" : 1089,
      "width" : 124,
      "height" : 37
    },
    "textPosition" : {
      "x" : 4250,
      "y" : 1091
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 4353,
          "y" : 1089
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 4353,
          "y" : 1089
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 59189,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 59193,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 4356,
          "y" : 1125
        },
        "to" : {
          "x" : 4456,
          "y" : 1157
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 59201,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 4343,
          "y" : 1086
        },
        "to" : {
          "x" : 4536,
          "y" : 1021
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 4348,
          "y" : 1080
        },
        "b" : {
          "x" : 4343,
          "y" : 1086
        },
        "c" : {
          "x" : 4351,
          "y" : 1088
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 4351,
          "y" : 1088
        }
      }
    } ]
  }, {
    "id" : 59194,
    "reactomeId" : 10263399,
    "displayName" : "C4b-binding protein:Factor I",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 4550,
      "y" : 1097
    },
    "minX" : 4502,
    "maxX" : 4604,
    "minY" : 1073,
    "maxY" : 1116,
    "prop" : {
      "x" : 4502,
      "y" : 1079,
      "width" : 96,
      "height" : 37
    },
    "textPosition" : {
      "x" : 4507,
      "y" : 1067
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 4598,
          "y" : 1079
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 4598,
          "y" : 1079
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 59193,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 59195,
      "type" : "INPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 59196,
    "reactomeId" : 10263285,
    "displayName" : "SKIC2",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 4509,
      "y" : 1262
    },
    "minX" : 4493,
    "maxX" : 4552,
    "minY" : 1188,
    "maxY" : 1274,
    "prop" : {
      "x" : 4493,
      "y" : 1251,
      "width" : 33,
      "height" : 23
    },
    "textPosition" : {
      "x" : 4496,
      "y" : 1245
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 4526,
          "y" : 1251
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 4526,
          "y" : 1251
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 59195,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 4515,
          "y" : 1245
        },
        "to" : {
          "x" : 4552,
          "y" : 1188
        }
      } ],
      "stoichiometry" : {
        "value" : 7,
        "shape" : {
          "a" : {
            "x" : 4527,
            "y" : 1210
          },
          "b" : {
            "x" : 4539,
            "y" : 1222
          },
          "type" : "BOX",
          "empty" : true,
          "centre" : {
            "x" : 4533,
            "y" : 1216
          }
        }
      },
      "endShape" : {
        "a" : {
          "x" : 4515,
          "y" : 1237
        },
        "b" : {
          "x" : 4515,
          "y" : 1245
        },
        "c" : {
          "x" : 4522,
          "y" : 1241
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 4522,
          "y" : 1241
        }
      }
    } ]
  }, {
    "id" : 59197,
    "reactomeId" : 10263295,
    "displayName" : "C4A-derived C4c",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 4595,
      "y" : 1261
    },
    "minX" : 4552,
    "maxX" : 4617,
    "minY" : 1188,
    "maxY" : 1273,
    "prop" : {
      "x" : 4580,
      "y" : 1250,
      "width" : 31,
      "height" : 23
    },
    "textPosition" : {
      "x" : 4580,
      "y" : 1216
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 4611,
          "y" : 1250
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 4611,
          "y" : 1250
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 59195,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 4588,
          "y" : 1244
        },
        "to" : {
          "x" : 4552,
          "y" : 1188
        }
      } ],
      "stoichiometry" : {
        "value" : 7,
        "shape" : {
          "a" : {
            "x" : 4564,
            "y" : 1210
          },
          "b" : {
            "x" : 4576,
            "y" : 1222
          },
          "type" : "BOX",
          "empty" : true,
          "centre" : {
            "x" : 4570,
            "y" : 1216
          }
        }
      },
      "endShape" : {
        "a" : {
          "x" : 4581,
          "y" : 1240
        },
        "b" : {
          "x" : 4588,
          "y" : 1244
        },
        "c" : {
          "x" : 4588,
          "y" : 1236
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 4588,
          "y" : 1236
        }
      }
    } ]
  }, {
    "id" : 59199,
    "reactomeId" : 10238083,
    "displayName" : "Cell surface:C4b:C2a",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 4515,
      "y" : 863
    },
    "minX" : 4450,
    "maxX" : 4617,
    "minY" : 846,
    "maxY" : 875,
    "prop" : {
      "x" : 4450,
      "y" : 852,
      "width" : 131,
      "height" : 23
    },
    "textPosition" : {
      "x" : 4459,
      "y" : 840
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 4581,
          "y" : 852
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 4581,
          "y" : 852
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 59198,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 4584,
          "y" : 858
        },
        "to" : {
          "x" : 4617,
          "y" : 856
        }
      } ],
      "stoichiometry" : {
        "value" : 7,
        "shape" : {
          "a" : {
            "x" : 4594,
            "y" : 851
          },
          "b" : {
            "x" : 4606,
            "y" : 863
          },
          "type" : "BOX",
          "empty" : true,
          "centre" : {
            "x" : 4600,
            "y" : 857
          }
        }
      }
    } ]
  }, {
    "id" : 59200,
    "reactomeId" : 10263403,
    "displayName" : "C4 binding protein:C4bC2a",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 4538,
      "y" : 940
    },
    "minX" : 4478,
    "maxX" : 4605,
    "minY" : 916,
    "maxY" : 959,
    "prop" : {
      "x" : 4478,
      "y" : 922,
      "width" : 121,
      "height" : 37
    },
    "textPosition" : {
      "x" : 4486,
      "y" : 924
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 4599,
          "y" : 922
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 4599,
          "y" : 922
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 59198,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 59201,
      "type" : "INPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 59202,
    "reactomeId" : 10238061,
    "displayName" : "C2",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 4611,
      "y" : 1023
    },
    "minX" : 4536,
    "maxX" : 4633,
    "minY" : 1006,
    "maxY" : 1035,
    "prop" : {
      "x" : 4595,
      "y" : 1012,
      "width" : 32,
      "height" : 23
    },
    "textPosition" : {
      "x" : 4599,
      "y" : 1013
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 4627,
          "y" : 1012
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 4627,
          "y" : 1012
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 59201,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 4592,
          "y" : 1022
        },
        "to" : {
          "x" : 4536,
          "y" : 1021
        }
      } ],
      "stoichiometry" : {
        "value" : 7,
        "shape" : {
          "a" : {
            "x" : 4558,
            "y" : 1015
          },
          "b" : {
            "x" : 4570,
            "y" : 1027
          },
          "type" : "BOX",
          "empty" : true,
          "centre" : {
            "x" : 4564,
            "y" : 1021
          }
        }
      },
      "endShape" : {
        "a" : {
          "x" : 4585,
          "y" : 1026
        },
        "b" : {
          "x" : 4592,
          "y" : 1022
        },
        "c" : {
          "x" : 4585,
          "y" : 1018
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 4585,
          "y" : 1018
        }
      }
    } ]
  }, {
    "id" : 59204,
    "reactomeId" : 1006146,
    "displayName" : "Host cell surface",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 3211,
      "y" : 1103
    },
    "minX" : 3159,
    "maxX" : 3269,
    "minY" : 1086,
    "maxY" : 1135,
    "prop" : {
      "x" : 3159,
      "y" : 1092,
      "width" : 104,
      "height" : 23
    },
    "textPosition" : {
      "x" : 3178,
      "y" : 1080
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 3263,
          "y" : 1092
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 3263,
          "y" : 1092
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 59203,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 3218,
          "y" : 1118
        },
        "to" : {
          "x" : 3231,
          "y" : 1135
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 59206,
    "reactomeId" : 10245523,
    "displayName" : "PROS1",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 4693,
      "y" : 708
    },
    "minX" : 4602,
    "maxX" : 4753,
    "minY" : 691,
    "maxY" : 720,
    "prop" : {
      "x" : 4640,
      "y" : 697,
      "width" : 107,
      "height" : 23
    },
    "textPosition" : {
      "x" : 4669,
      "y" : 698
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 4747,
          "y" : 697
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 4747,
          "y" : 697
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 59205,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 4637,
          "y" : 712
        },
        "to" : {
          "x" : 4602,
          "y" : 715
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 59207,
    "reactomeId" : 10263409,
    "displayName" : "C4 binding protein:protein S",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 4555,
      "y" : 631
    },
    "minX" : 4495,
    "maxX" : 4622,
    "minY" : 607,
    "maxY" : 650,
    "prop" : {
      "x" : 4495,
      "y" : 613,
      "width" : 121,
      "height" : 37
    },
    "textPosition" : {
      "x" : 4498,
      "y" : 615
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 4616,
          "y" : 613
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 4616,
          "y" : 613
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 59205,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 59209,
    "reactomeId" : 10280976,
    "displayName" : "FCN1 dodecamer:MASP1 dimer:MASP2-1 dimer",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 113,
      "y" : 771
    },
    "minX" : 56,
    "maxX" : 206,
    "minY" : 740,
    "maxY" : 797,
    "prop" : {
      "x" : 56,
      "y" : 746,
      "width" : 114,
      "height" : 51
    },
    "textPosition" : {
      "x" : 62,
      "y" : 734
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 170,
          "y" : 746
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 170,
          "y" : 746
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 59208,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 173,
          "y" : 780
        },
        "to" : {
          "x" : 206,
          "y" : 786
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 59210,
    "reactomeId" : 2855114,
    "displayName" : "FCN1 ligands",
    "schemaClass" : "DefinedSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 287,
      "y" : 770
    },
    "minX" : 206,
    "maxX" : 330,
    "minY" : 759,
    "maxY" : 786,
    "prop" : {
      "x" : 245,
      "y" : 759,
      "width" : 85,
      "height" : 23
    },
    "textPosition" : {
      "x" : 261,
      "y" : 753
    },
    "connectors" : [ {
      "edgeId" : 59208,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 239,
          "y" : 778
        },
        "to" : {
          "x" : 206,
          "y" : 786
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 59211,
    "reactomeId" : 74112,
    "displayName" : "Ca2+",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 208,
      "y" : 731
    },
    "minX" : 183,
    "maxX" : 234,
    "minY" : 715,
    "maxY" : 786,
    "prop" : {
      "x" : 183,
      "y" : 716,
      "width" : 50,
      "height" : 31
    },
    "textPosition" : {
      "x" : 187,
      "y" : 721
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 228,
          "y" : 721
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 228,
          "y" : 721
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 59208,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 207,
          "y" : 750
        },
        "to" : {
          "x" : 206,
          "y" : 786
        }
      } ],
      "stoichiometry" : {
        "value" : 4,
        "shape" : {
          "a" : {
            "x" : 200,
            "y" : 762
          },
          "b" : {
            "x" : 212,
            "y" : 774
          },
          "type" : "BOX",
          "empty" : true,
          "centre" : {
            "x" : 206,
            "y" : 768
          }
        }
      }
    } ]
  }, {
    "id" : 59212,
    "reactomeId" : 10280978,
    "displayName" : "FCN1 ligands:FCN1 dodecamer:MASP1 dimer:MASP2-1 dimer:4xCa2+",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 297,
      "y" : 833
    },
    "minX" : 235,
    "maxX" : 365,
    "minY" : 795,
    "maxY" : 866,
    "prop" : {
      "x" : 235,
      "y" : 801,
      "width" : 124,
      "height" : 65
    },
    "textPosition" : {
      "x" : 237,
      "y" : 789
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 359,
          "y" : 801
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 359,
          "y" : 801
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 59208,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 59214,
    "reactomeId" : 2855063,
    "displayName" : "FCN2 ligands",
    "schemaClass" : "DefinedSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 292,
      "y" : 911
    },
    "minX" : 203,
    "maxX" : 335,
    "minY" : 900,
    "maxY" : 939,
    "prop" : {
      "x" : 250,
      "y" : 900,
      "width" : 85,
      "height" : 23
    },
    "textPosition" : {
      "x" : 266,
      "y" : 894
    },
    "connectors" : [ {
      "edgeId" : 59213,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 255,
          "y" : 929
        },
        "to" : {
          "x" : 203,
          "y" : 939
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 59215,
    "reactomeId" : 10280964,
    "displayName" : "FCN2 dodecamer:MASP1 dimer:MASP2-1 dimer",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 112,
      "y" : 922
    },
    "minX" : 55,
    "maxX" : 203,
    "minY" : 891,
    "maxY" : 948,
    "prop" : {
      "x" : 55,
      "y" : 897,
      "width" : 114,
      "height" : 51
    },
    "textPosition" : {
      "x" : 61,
      "y" : 885
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 169,
          "y" : 897
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 169,
          "y" : 897
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 59213,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 172,
          "y" : 932
        },
        "to" : {
          "x" : 203,
          "y" : 939
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 59216,
    "reactomeId" : 74112,
    "displayName" : "Ca2+",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 204,
      "y" : 890
    },
    "minX" : 179,
    "maxX" : 230,
    "minY" : 874,
    "maxY" : 939,
    "prop" : {
      "x" : 179,
      "y" : 875,
      "width" : 50,
      "height" : 31
    },
    "textPosition" : {
      "x" : 183,
      "y" : 880
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 224,
          "y" : 880
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 224,
          "y" : 880
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 59213,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 203,
          "y" : 909
        },
        "to" : {
          "x" : 203,
          "y" : 939
        }
      } ],
      "stoichiometry" : {
        "value" : 4,
        "shape" : {
          "a" : {
            "x" : 197,
            "y" : 918
          },
          "b" : {
            "x" : 209,
            "y" : 930
          },
          "type" : "BOX",
          "empty" : true,
          "centre" : {
            "x" : 203,
            "y" : 924
          }
        }
      }
    } ]
  }, {
    "id" : 59217,
    "reactomeId" : 10280966,
    "displayName" : "FCN2 ligands:FCN2 dodecamer:MASP1 dimer:MASP2-1 dimer:4xCa2+",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 294,
      "y" : 969
    },
    "minX" : 232,
    "maxX" : 362,
    "minY" : 931,
    "maxY" : 1002,
    "prop" : {
      "x" : 232,
      "y" : 937,
      "width" : 124,
      "height" : 65
    },
    "textPosition" : {
      "x" : 234,
      "y" : 925
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 356,
          "y" : 937
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 356,
          "y" : 937
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 59213,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 59219,
    "reactomeId" : 10263088,
    "displayName" : "iC3b",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 3073,
      "y" : 1283
    },
    "minX" : 3055,
    "maxX" : 3131,
    "minY" : 1249,
    "maxY" : 1295,
    "prop" : {
      "x" : 3055,
      "y" : 1272,
      "width" : 36,
      "height" : 23
    },
    "textPosition" : {
      "x" : 3055,
      "y" : 1274
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 3091,
          "y" : 1272
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 3091,
          "y" : 1272
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 59218,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 3094,
          "y" : 1272
        },
        "to" : {
          "x" : 3131,
          "y" : 1249
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 3098,
          "y" : 1265
        },
        "b" : {
          "x" : 3094,
          "y" : 1272
        },
        "c" : {
          "x" : 3102,
          "y" : 1272
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 3102,
          "y" : 1272
        }
      }
    } ]
  }, {
    "id" : 59221,
    "reactomeId" : 10282408,
    "displayName" : "CR1:iC3b",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 3464,
      "y" : 1108
    },
    "minX" : 3432,
    "maxX" : 3502,
    "minY" : 1091,
    "maxY" : 1120,
    "prop" : {
      "x" : 3432,
      "y" : 1097,
      "width" : 64,
      "height" : 23
    },
    "textPosition" : {
      "x" : 3432,
      "y" : 1099
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 3496,
          "y" : 1097
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 3496,
          "y" : 1097
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 59220,
      "type" : "INPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 59222,
    "reactomeId" : 10282414,
    "displayName" : "C3",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 3590,
      "y" : 1106
    },
    "minX" : 3545,
    "maxX" : 3616,
    "minY" : 1089,
    "maxY" : 1118,
    "prop" : {
      "x" : 3570,
      "y" : 1095,
      "width" : 40,
      "height" : 23
    },
    "textPosition" : {
      "x" : 3578,
      "y" : 1096
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 3610,
          "y" : 1095
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 3610,
          "y" : 1095
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 59220,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 3567,
          "y" : 1107
        },
        "to" : {
          "x" : 3545,
          "y" : 1110
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 3561,
          "y" : 1112
        },
        "b" : {
          "x" : 3567,
          "y" : 1107
        },
        "c" : {
          "x" : 3560,
          "y" : 1104
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 3560,
          "y" : 1104
        }
      }
    } ]
  }, {
    "id" : 59223,
    "reactomeId" : 10282412,
    "displayName" : "C3c",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 3558,
      "y" : 1151
    },
    "minX" : 3543,
    "maxX" : 3580,
    "minY" : 1110,
    "maxY" : 1163,
    "prop" : {
      "x" : 3543,
      "y" : 1140,
      "width" : 31,
      "height" : 23
    },
    "textPosition" : {
      "x" : 3543,
      "y" : 1142
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 3574,
          "y" : 1140
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 3574,
          "y" : 1140
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 59220,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 3554,
          "y" : 1137
        },
        "to" : {
          "x" : 3545,
          "y" : 1110
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 3548,
          "y" : 1132
        },
        "b" : {
          "x" : 3554,
          "y" : 1137
        },
        "c" : {
          "x" : 3556,
          "y" : 1129
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 3556,
          "y" : 1129
        }
      }
    } ]
  }, {
    "id" : 59225,
    "reactomeId" : 10280050,
    "displayName" : "CD59",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 2748,
      "y" : 636
    },
    "minX" : 2692,
    "maxX" : 2775,
    "minY" : 619,
    "maxY" : 657,
    "prop" : {
      "x" : 2727,
      "y" : 625,
      "width" : 42,
      "height" : 23
    },
    "textPosition" : {
      "x" : 2727,
      "y" : 626
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 2769,
          "y" : 625
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 2769,
          "y" : 625
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 59224,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 2724,
          "y" : 643
        },
        "to" : {
          "x" : 2692,
          "y" : 657
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 59226,
    "reactomeId" : 10239616,
    "displayName" : "C5b:C6:C7:C8",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 2740,
      "y" : 593
    },
    "minX" : 2692,
    "maxX" : 2793,
    "minY" : 576,
    "maxY" : 657,
    "prop" : {
      "x" : 2694,
      "y" : 582,
      "width" : 93,
      "height" : 23
    },
    "textPosition" : {
      "x" : 2694,
      "y" : 584
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 2787,
          "y" : 582
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 2787,
          "y" : 582
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 59224,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 2731,
          "y" : 608
        },
        "to" : {
          "x" : 2692,
          "y" : 657
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 59227,
    "reactomeId" : 10280052,
    "displayName" : "CD59:C5b-C9",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 2740,
      "y" : 731
    },
    "minX" : 2694,
    "maxX" : 2793,
    "minY" : 714,
    "maxY" : 743,
    "prop" : {
      "x" : 2694,
      "y" : 720,
      "width" : 93,
      "height" : 23
    },
    "textPosition" : {
      "x" : 2696,
      "y" : 722
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 2787,
          "y" : 720
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 2787,
          "y" : 720
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 59224,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 59229,
    "reactomeId" : 10280044,
    "displayName" : "VTN:C5b:C6:C7",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 2564,
      "y" : 451
    },
    "minX" : 2427,
    "maxX" : 2621,
    "minY" : 434,
    "maxY" : 568,
    "prop" : {
      "x" : 2513,
      "y" : 440,
      "width" : 102,
      "height" : 23
    },
    "textPosition" : {
      "x" : 2514,
      "y" : 442
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 2615,
          "y" : 440
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 2615,
          "y" : 440
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 59228,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 2550,
          "y" : 466
        },
        "to" : {
          "x" : 2427,
          "y" : 568
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 59232,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 59230,
    "reactomeId" : 10239605,
    "displayName" : "C9",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 2483,
      "y" : 567
    },
    "minX" : 2427,
    "maxX" : 2529,
    "minY" : 550,
    "maxY" : 579,
    "prop" : {
      "x" : 2443,
      "y" : 556,
      "width" : 80,
      "height" : 23
    },
    "textPosition" : {
      "x" : 2471,
      "y" : 557
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 2523,
          "y" : 556
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 2523,
          "y" : 556
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 59228,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 2440,
          "y" : 567
        },
        "to" : {
          "x" : 2427,
          "y" : 568
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 59231,
    "reactomeId" : 10280046,
    "displayName" : "VTN:C5b:C6:C7:C8:C9",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 2426,
      "y" : 634
    },
    "minX" : 2363,
    "maxX" : 2495,
    "minY" : 610,
    "maxY" : 653,
    "prop" : {
      "x" : 2363,
      "y" : 616,
      "width" : 126,
      "height" : 37
    },
    "textPosition" : {
      "x" : 2364,
      "y" : 618
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 2489,
          "y" : 616
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 2489,
          "y" : 616
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 59228,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 59233,
    "reactomeId" : 10247951,
    "displayName" : "VTN",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 2603,
      "y" : 352
    },
    "minX" : 2563,
    "maxX" : 2626,
    "minY" : 335,
    "maxY" : 376,
    "prop" : {
      "x" : 2586,
      "y" : 341,
      "width" : 34,
      "height" : 23
    },
    "textPosition" : {
      "x" : 2587,
      "y" : 342
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 2620,
          "y" : 341
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 2620,
          "y" : 341
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 59232,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 2583,
          "y" : 362
        },
        "to" : {
          "x" : 2563,
          "y" : 376
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 59235,
    "reactomeId" : 109276,
    "displayName" : "H2O",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 4766,
      "y" : 834
    },
    "minX" : 4726,
    "maxX" : 4789,
    "minY" : 818,
    "maxY" : 856,
    "prop" : {
      "x" : 4745,
      "y" : 819,
      "width" : 43,
      "height" : 31
    },
    "textPosition" : {
      "x" : 4749,
      "y" : 824
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 4783,
          "y" : 824
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 4783,
          "y" : 824
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 59234,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 4742,
          "y" : 845
        },
        "to" : {
          "x" : 4726,
          "y" : 856
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ],
    "trivial" : true
  }, {
    "id" : 59236,
    "reactomeId" : 10238072,
    "displayName" : "deamidated-Q1013-C4A-derived C4b",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 4729,
      "y" : 941
    },
    "minX" : 4664,
    "maxX" : 4801,
    "minY" : 917,
    "maxY" : 960,
    "prop" : {
      "x" : 4664,
      "y" : 923,
      "width" : 131,
      "height" : 37
    },
    "textPosition" : {
      "x" : 4664,
      "y" : 917
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 4795,
          "y" : 923
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 4795,
          "y" : 923
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 59234,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 59238,
    "reactomeId" : 10251369,
    "displayName" : "C3AR1",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 897,
      "y" : 1163
    },
    "minX" : 873,
    "maxX" : 928,
    "minY" : 1146,
    "maxY" : 1190,
    "prop" : {
      "x" : 873,
      "y" : 1152,
      "width" : 49,
      "height" : 23
    },
    "textPosition" : {
      "x" : 873,
      "y" : 1153
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 922,
          "y" : 1152
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 922,
          "y" : 1152
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 59237,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 906,
          "y" : 1178
        },
        "to" : {
          "x" : 919,
          "y" : 1190
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 59239,
    "reactomeId" : 10251371,
    "displayName" : "C3AR1:C3a",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 1016,
      "y" : 1162
    },
    "minX" : 978,
    "maxX" : 1060,
    "minY" : 1145,
    "maxY" : 1174,
    "prop" : {
      "x" : 978,
      "y" : 1151,
      "width" : 76,
      "height" : 23
    },
    "textPosition" : {
      "x" : 978,
      "y" : 1153
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1054,
          "y" : 1151
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1054,
          "y" : 1151
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 59237,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 59241,
    "reactomeId" : 10236383,
    "displayName" : "SERPING1",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 1039,
      "y" : 173
    },
    "minX" : 1006,
    "maxX" : 1110,
    "minY" : 156,
    "maxY" : 203,
    "prop" : {
      "x" : 1006,
      "y" : 162,
      "width" : 66,
      "height" : 23
    },
    "textPosition" : {
      "x" : 1008,
      "y" : 156
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1072,
          "y" : 162
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1072,
          "y" : 162
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 59240,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1066,
          "y" : 188
        },
        "to" : {
          "x" : 1110,
          "y" : 203
        }
      } ],
      "stoichiometry" : {
        "value" : 4,
        "shape" : {
          "a" : {
            "x" : 1082,
            "y" : 189
          },
          "b" : {
            "x" : 1094,
            "y" : 201
          },
          "type" : "BOX",
          "empty" : true,
          "centre" : {
            "x" : 1088,
            "y" : 195
          }
        }
      }
    } ]
  }, {
    "id" : 59242,
    "reactomeId" : 10307402,
    "displayName" : "Antigen:IgG:C1Q:2xActivated C1R:2xActivated C1S",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 1213,
      "y" : 259
    },
    "minX" : 1159,
    "maxX" : 1274,
    "minY" : 228,
    "maxY" : 285,
    "prop" : {
      "x" : 1159,
      "y" : 234,
      "width" : 109,
      "height" : 51
    },
    "textPosition" : {
      "x" : 1157,
      "y" : 222
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1268,
          "y" : 234
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1268,
          "y" : 234
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 59289,
      "type" : "INPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 59240,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 59244,
    "reactomeId" : 10307461,
    "displayName" : "Antigen:IgG:C1Q:2xActivated C1R:SERPING1:2xActivated C1S:SERPING1",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 1361,
      "y" : 261
    },
    "minX" : 1307,
    "maxX" : 1422,
    "minY" : 216,
    "maxY" : 301,
    "prop" : {
      "x" : 1307,
      "y" : 222,
      "width" : 109,
      "height" : 79
    },
    "textPosition" : {
      "x" : 1305,
      "y" : 224
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1416,
          "y" : 222
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1416,
          "y" : 222
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 59289,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 59243,
      "type" : "INPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 59245,
    "reactomeId" : 10307457,
    "displayName" : "Activated C1S:SERPING1",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 1285,
      "y" : 126
    },
    "minX" : 1239,
    "maxX" : 1407,
    "minY" : 102,
    "maxY" : 205,
    "prop" : {
      "x" : 1239,
      "y" : 108,
      "width" : 92,
      "height" : 37
    },
    "textPosition" : {
      "x" : 1250,
      "y" : 96
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1331,
          "y" : 108
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1331,
          "y" : 108
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 59243,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 1313,
          "y" : 148
        },
        "to" : {
          "x" : 1407,
          "y" : 205
        }
      } ],
      "stoichiometry" : {
        "value" : 2,
        "shape" : {
          "a" : {
            "x" : 1354,
            "y" : 170
          },
          "b" : {
            "x" : 1366,
            "y" : 182
          },
          "type" : "BOX",
          "empty" : true,
          "centre" : {
            "x" : 1360,
            "y" : 176
          }
        }
      },
      "endShape" : {
        "a" : {
          "x" : 1321,
          "y" : 148
        },
        "b" : {
          "x" : 1313,
          "y" : 148
        },
        "c" : {
          "x" : 1317,
          "y" : 155
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 1317,
          "y" : 155
        }
      }
    } ]
  }, {
    "id" : 59246,
    "reactomeId" : 10239487,
    "displayName" : "C1Q",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 1366,
      "y" : 125
    },
    "minX" : 1349,
    "maxX" : 1407,
    "minY" : 108,
    "maxY" : 205,
    "prop" : {
      "x" : 1349,
      "y" : 114,
      "width" : 34,
      "height" : 23
    },
    "textPosition" : {
      "x" : 1349,
      "y" : 116
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1383,
          "y" : 114
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1383,
          "y" : 114
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 59243,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 1371,
          "y" : 140
        },
        "to" : {
          "x" : 1407,
          "y" : 205
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 1378,
          "y" : 144
        },
        "b" : {
          "x" : 1371,
          "y" : 140
        },
        "c" : {
          "x" : 1371,
          "y" : 148
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 1371,
          "y" : 148
        }
      }
    } ]
  }, {
    "id" : 59247,
    "reactomeId" : 10239471,
    "displayName" : "Antigen:IgG",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 1492,
      "y" : 257
    },
    "minX" : 1407,
    "maxX" : 1536,
    "minY" : 205,
    "maxY" : 269,
    "prop" : {
      "x" : 1455,
      "y" : 246,
      "width" : 75,
      "height" : 23
    },
    "textPosition" : {
      "x" : 1462,
      "y" : 234
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1530,
          "y" : 246
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1530,
          "y" : 246
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 59243,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 1473,
          "y" : 243
        },
        "to" : {
          "x" : 1407,
          "y" : 205
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 1465,
          "y" : 243
        },
        "b" : {
          "x" : 1473,
          "y" : 243
        },
        "c" : {
          "x" : 1469,
          "y" : 236
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 1469,
          "y" : 236
        }
      }
    } ]
  }, {
    "id" : 59248,
    "reactomeId" : 10307455,
    "displayName" : "Activated C1R:SERPING1",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 1439,
      "y" : 123
    },
    "minX" : 1392,
    "maxX" : 1492,
    "minY" : 99,
    "maxY" : 205,
    "prop" : {
      "x" : 1392,
      "y" : 105,
      "width" : 94,
      "height" : 37
    },
    "textPosition" : {
      "x" : 1404,
      "y" : 93
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1486,
          "y" : 105
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1486,
          "y" : 105
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 59243,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 1431,
          "y" : 145
        },
        "to" : {
          "x" : 1407,
          "y" : 205
        }
      } ],
      "stoichiometry" : {
        "value" : 2,
        "shape" : {
          "a" : {
            "x" : 1413,
            "y" : 169
          },
          "b" : {
            "x" : 1425,
            "y" : 181
          },
          "type" : "BOX",
          "empty" : true,
          "centre" : {
            "x" : 1419,
            "y" : 175
          }
        }
      },
      "endShape" : {
        "a" : {
          "x" : 1432,
          "y" : 153
        },
        "b" : {
          "x" : 1431,
          "y" : 145
        },
        "c" : {
          "x" : 1425,
          "y" : 150
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 1425,
          "y" : 150
        }
      }
    } ]
  }, {
    "id" : 59250,
    "reactomeId" : 10262704,
    "displayName" : "C5AR2",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 438,
      "y" : 1159
    },
    "minX" : 414,
    "maxX" : 488,
    "minY" : 1142,
    "maxY" : 1184,
    "prop" : {
      "x" : 414,
      "y" : 1148,
      "width" : 49,
      "height" : 23
    },
    "textPosition" : {
      "x" : 414,
      "y" : 1149
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 463,
          "y" : 1148
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 463,
          "y" : 1148
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 59249,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 461,
          "y" : 1174
        },
        "to" : {
          "x" : 488,
          "y" : 1184
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 59251,
    "reactomeId" : 10262700,
    "displayName" : "C5AR2 ligands",
    "schemaClass" : "CandidateSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 444,
      "y" : 1220
    },
    "minX" : 397,
    "maxX" : 491,
    "minY" : 1184,
    "maxY" : 1232,
    "prop" : {
      "x" : 397,
      "y" : 1209,
      "width" : 94,
      "height" : 23
    },
    "textPosition" : {
      "x" : 417,
      "y" : 1203
    },
    "connectors" : [ {
      "edgeId" : 59249,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 458,
          "y" : 1203
        },
        "to" : {
          "x" : 488,
          "y" : 1184
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 59252,
    "reactomeId" : 10262706,
    "displayName" : "C5AR2:C5AR2 ligands",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 609,
      "y" : 1164
    },
    "minX" : 561,
    "maxX" : 664,
    "minY" : 1140,
    "maxY" : 1183,
    "prop" : {
      "x" : 561,
      "y" : 1146,
      "width" : 97,
      "height" : 37
    },
    "textPosition" : {
      "x" : 561,
      "y" : 1148
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 658,
          "y" : 1146
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 658,
          "y" : 1146
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 59249,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 59254,
    "reactomeId" : 166718,
    "displayName" : "Bacterial mannose surface pattern",
    "schemaClass" : "OtherEntity",
    "renderableClass" : "Entity",
    "position" : {
      "x" : 283,
      "y" : 529
    },
    "minX" : 206,
    "maxX" : 342,
    "minY" : 511,
    "maxY" : 595,
    "prop" : {
      "x" : 224,
      "y" : 511,
      "width" : 118,
      "height" : 37
    },
    "textPosition" : {
      "x" : 223,
      "y" : 505
    },
    "connectors" : [ {
      "edgeId" : 59253,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 261,
          "y" : 551
        },
        "to" : {
          "x" : 206,
          "y" : 595
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 59255,
    "reactomeId" : 74112,
    "displayName" : "Ca2+",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 178,
      "y" : 527
    },
    "minX" : 153,
    "maxX" : 206,
    "minY" : 511,
    "maxY" : 595,
    "prop" : {
      "x" : 153,
      "y" : 512,
      "width" : 50,
      "height" : 31
    },
    "textPosition" : {
      "x" : 157,
      "y" : 517
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 198,
          "y" : 517
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 198,
          "y" : 517
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 59253,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 184,
          "y" : 546
        },
        "to" : {
          "x" : 206,
          "y" : 595
        }
      } ],
      "stoichiometry" : {
        "value" : 4,
        "shape" : {
          "a" : {
            "x" : 189,
            "y" : 564
          },
          "b" : {
            "x" : 201,
            "y" : 576
          },
          "type" : "BOX",
          "empty" : true,
          "centre" : {
            "x" : 195,
            "y" : 570
          }
        }
      }
    } ]
  }, {
    "id" : 59256,
    "reactomeId" : 10307473,
    "displayName" : "CL-LK:MASP1 dimer:MASP2 dimer",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 64,
      "y" : 545
    },
    "minX" : 0,
    "maxX" : 206,
    "minY" : 521,
    "maxY" : 595,
    "prop" : {
      "x" : 0,
      "y" : 527,
      "width" : 129,
      "height" : 37
    },
    "textPosition" : {
      "x" : 0,
      "y" : 529
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 129,
          "y" : 527
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 129,
          "y" : 527
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 59253,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 116,
          "y" : 567
        },
        "to" : {
          "x" : 206,
          "y" : 595
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 59257,
    "reactomeId" : 10307475,
    "displayName" : "CL-LK:MASP1 dimer:MASP2 dimer:Bacterial mannose surface pattern:4xCa2+",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 296,
      "y" : 650
    },
    "minX" : 232,
    "maxX" : 367,
    "minY" : 605,
    "maxY" : 690,
    "prop" : {
      "x" : 232,
      "y" : 611,
      "width" : 129,
      "height" : 79
    },
    "textPosition" : {
      "x" : 232,
      "y" : 613
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 361,
          "y" : 611
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 361,
          "y" : 611
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 59253,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 59259,
    "reactomeId" : 10249962,
    "displayName" : "C5AR1",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 2330,
      "y" : 295
    },
    "minX" : 2306,
    "maxX" : 2406,
    "minY" : 278,
    "maxY" : 379,
    "prop" : {
      "x" : 2306,
      "y" : 284,
      "width" : 49,
      "height" : 23
    },
    "textPosition" : {
      "x" : 2306,
      "y" : 285
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 2355,
          "y" : 284
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 2355,
          "y" : 284
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 59299,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 2340,
          "y" : 310
        },
        "to" : {
          "x" : 2406,
          "y" : 379
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 59258,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 2345,
          "y" : 310
        },
        "to" : {
          "x" : 2377,
          "y" : 329
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 59260,
    "reactomeId" : 10249964,
    "displayName" : "C5AR1:C5a",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 2338,
      "y" : 405
    },
    "minX" : 2300,
    "maxX" : 2382,
    "minY" : 388,
    "maxY" : 417,
    "prop" : {
      "x" : 2300,
      "y" : 394,
      "width" : 76,
      "height" : 23
    },
    "textPosition" : {
      "x" : 2300,
      "y" : 396
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 2376,
          "y" : 394
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 2376,
          "y" : 394
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 59258,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 59262,
    "reactomeId" : 10239587,
    "displayName" : "CLU",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 2669,
      "y" : 502
    },
    "minX" : 2616,
    "maxX" : 2691,
    "minY" : 485,
    "maxY" : 550,
    "prop" : {
      "x" : 2654,
      "y" : 491,
      "width" : 31,
      "height" : 23
    },
    "textPosition" : {
      "x" : 2654,
      "y" : 493
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 2685,
          "y" : 491
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 2685,
          "y" : 491
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 59261,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 2656,
          "y" : 517
        },
        "to" : {
          "x" : 2616,
          "y" : 550
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 59263,
    "reactomeId" : 10239607,
    "displayName" : "C5b:C6:C7, C8, C9",
    "schemaClass" : "DefinedSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 2587,
      "y" : 508
    },
    "minX" : 2527,
    "maxX" : 2648,
    "minY" : 497,
    "maxY" : 550,
    "prop" : {
      "x" : 2527,
      "y" : 497,
      "width" : 121,
      "height" : 23
    },
    "textPosition" : {
      "x" : 2527,
      "y" : 498
    },
    "connectors" : [ {
      "edgeId" : 59261,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 2594,
          "y" : 526
        },
        "to" : {
          "x" : 2616,
          "y" : 550
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 59265,
    "reactomeId" : 10307502,
    "displayName" : "C5bT",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 2438,
      "y" : 33
    },
    "minX" : 2414,
    "maxX" : 2465,
    "minY" : 16,
    "maxY" : 76,
    "prop" : {
      "x" : 2418,
      "y" : 22,
      "width" : 41,
      "height" : 23
    },
    "textPosition" : {
      "x" : 2419,
      "y" : 24
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 2459,
          "y" : 22
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 2459,
          "y" : 22
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 59264,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 2431,
          "y" : 48
        },
        "to" : {
          "x" : 2414,
          "y" : 76
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 2431,
          "y" : 56
        },
        "b" : {
          "x" : 2431,
          "y" : 48
        },
        "c" : {
          "x" : 2424,
          "y" : 52
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 2424,
          "y" : 52
        }
      }
    } ]
  }, {
    "id" : 59266,
    "reactomeId" : 10307498,
    "displayName" : "C5",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 2478,
      "y" : 77
    },
    "minX" : 2414,
    "maxX" : 2504,
    "minY" : 60,
    "maxY" : 89,
    "prop" : {
      "x" : 2458,
      "y" : 66,
      "width" : 40,
      "height" : 23
    },
    "textPosition" : {
      "x" : 2466,
      "y" : 67
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 2498,
          "y" : 66
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 2498,
          "y" : 66
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 59264,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 2455,
          "y" : 76
        },
        "to" : {
          "x" : 2414,
          "y" : 76
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 2448,
          "y" : 80
        },
        "b" : {
          "x" : 2455,
          "y" : 76
        },
        "c" : {
          "x" : 2448,
          "y" : 72
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 2448,
          "y" : 72
        }
      }
    } ]
  }, {
    "id" : 59267,
    "reactomeId" : 10307504,
    "displayName" : "Activated thrombin, (ELANE)",
    "schemaClass" : "CandidateSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 2325,
      "y" : 18
    },
    "minX" : 2262,
    "maxX" : 2388,
    "minY" : 0,
    "maxY" : 68,
    "prop" : {
      "x" : 2262,
      "y" : 0,
      "width" : 126,
      "height" : 37
    },
    "textPosition" : {
      "x" : 2264,
      "y" : 1
    },
    "connectors" : [ {
      "edgeId" : 59264,
      "type" : "CATALYST",
      "segments" : [ {
        "from" : {
          "x" : 2324,
          "y" : 43
        },
        "to" : {
          "x" : 2324,
          "y" : 60
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 2324,
          "y" : 64
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 2324,
          "y" : 64
        }
      }
    } ]
  }, {
    "id" : 59269,
    "reactomeId" : 10307046,
    "displayName" : "CFHR dimers",
    "schemaClass" : "DefinedSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 2397,
      "y" : 1026
    },
    "minX" : 2355,
    "maxX" : 2439,
    "minY" : 1015,
    "maxY" : 1075,
    "prop" : {
      "x" : 2355,
      "y" : 1015,
      "width" : 84,
      "height" : 23
    },
    "textPosition" : {
      "x" : 2372,
      "y" : 1009
    },
    "connectors" : [ {
      "edgeId" : 59268,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 2390,
          "y" : 1044
        },
        "to" : {
          "x" : 2368,
          "y" : 1075
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 59270,
    "reactomeId" : 10307048,
    "displayName" : "Cell surface:C3b:CFHR dimers",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 2344,
      "y" : 1158
    },
    "minX" : 2290,
    "maxX" : 2404,
    "minY" : 1134,
    "maxY" : 1177,
    "prop" : {
      "x" : 2290,
      "y" : 1140,
      "width" : 108,
      "height" : 37
    },
    "textPosition" : {
      "x" : 2301,
      "y" : 1128
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 2398,
          "y" : 1140
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 2398,
          "y" : 1140
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 59268,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 59272,
    "reactomeId" : 10307530,
    "displayName" : "LOC490269",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 4229,
      "y" : 278
    },
    "minX" : 4213,
    "maxX" : 4281,
    "minY" : 243,
    "maxY" : 290,
    "prop" : {
      "x" : 4213,
      "y" : 267,
      "width" : 33,
      "height" : 23
    },
    "textPosition" : {
      "x" : 4213,
      "y" : 254
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 4246,
          "y" : 267
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 4246,
          "y" : 267
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 59271,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 4246,
          "y" : 264
        },
        "to" : {
          "x" : 4281,
          "y" : 243
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 59273,
    "reactomeId" : 10307534,
    "displayName" : "C3d, C3dg, iC3b",
    "schemaClass" : "DefinedSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 4322,
      "y" : 276
    },
    "minX" : 4269,
    "maxX" : 4376,
    "minY" : 243,
    "maxY" : 288,
    "prop" : {
      "x" : 4269,
      "y" : 265,
      "width" : 107,
      "height" : 23
    },
    "textPosition" : {
      "x" : 4269,
      "y" : 266
    },
    "connectors" : [ {
      "edgeId" : 59271,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 4307,
          "y" : 259
        },
        "to" : {
          "x" : 4281,
          "y" : 243
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 59274,
    "reactomeId" : 10307536,
    "displayName" : "CR2:C3d,C3dg,iC3b",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 4454,
      "y" : 275
    },
    "minX" : 4391,
    "maxX" : 4524,
    "minY" : 258,
    "maxY" : 300,
    "prop" : {
      "x" : 4391,
      "y" : 264,
      "width" : 127,
      "height" : 23
    },
    "textPosition" : {
      "x" : 4391,
      "y" : 266
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 4518,
          "y" : 264
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 4518,
          "y" : 264
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 59271,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 59275,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 4473,
          "y" : 290
        },
        "to" : {
          "x" : 4496,
          "y" : 300
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 59276,
    "reactomeId" : 10307540,
    "displayName" : "CD19:CD81",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 4574,
      "y" : 279
    },
    "minX" : 4496,
    "maxX" : 4620,
    "minY" : 262,
    "maxY" : 300,
    "prop" : {
      "x" : 4535,
      "y" : 268,
      "width" : 79,
      "height" : 23
    },
    "textPosition" : {
      "x" : 4535,
      "y" : 270
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 4614,
          "y" : 268
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 4614,
          "y" : 268
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 59275,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 4532,
          "y" : 289
        },
        "to" : {
          "x" : 4496,
          "y" : 300
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 59277,
    "reactomeId" : 10307542,
    "displayName" : "CR2:C3d,C3dg,iC3b:CD19:CD81",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 4585,
      "y" : 326
    },
    "minX" : 4520,
    "maxX" : 4657,
    "minY" : 302,
    "maxY" : 345,
    "prop" : {
      "x" : 4520,
      "y" : 308,
      "width" : 131,
      "height" : 37
    },
    "textPosition" : {
      "x" : 4520,
      "y" : 310
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 4651,
          "y" : 308
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 4651,
          "y" : 308
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 59275,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 59279,
    "reactomeId" : 10307509,
    "displayName" : "C3a, C5a",
    "schemaClass" : "DefinedSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 363,
      "y" : 1341
    },
    "minX" : 332,
    "maxX" : 395,
    "minY" : 1330,
    "maxY" : 1353,
    "prop" : {
      "x" : 332,
      "y" : 1330,
      "width" : 63,
      "height" : 23
    },
    "textPosition" : {
      "x" : 343,
      "y" : 1324
    },
    "connectors" : [ {
      "edgeId" : 59278,
      "type" : "INPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 59280,
    "reactomeId" : 10307511,
    "displayName" : "C3a-desArg, C5a-desArg",
    "schemaClass" : "DefinedSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 529,
      "y" : 1342
    },
    "minX" : 470,
    "maxX" : 588,
    "minY" : 1324,
    "maxY" : 1361,
    "prop" : {
      "x" : 470,
      "y" : 1324,
      "width" : 118,
      "height" : 37
    },
    "textPosition" : {
      "x" : 471,
      "y" : 1325
    },
    "connectors" : [ {
      "edgeId" : 59278,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 59281,
    "reactomeId" : 10307523,
    "displayName" : "CPN, CBP2",
    "schemaClass" : "DefinedSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 433,
      "y" : 1293
    },
    "minX" : 398,
    "maxX" : 469,
    "minY" : 1282,
    "maxY" : 1333,
    "prop" : {
      "x" : 398,
      "y" : 1282,
      "width" : 71,
      "height" : 23
    },
    "textPosition" : {
      "x" : 413,
      "y" : 1276
    },
    "connectors" : [ {
      "edgeId" : 59278,
      "type" : "CATALYST",
      "segments" : [ {
        "from" : {
          "x" : 433,
          "y" : 1311
        },
        "to" : {
          "x" : 433,
          "y" : 1325
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 433,
          "y" : 1329
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 433,
          "y" : 1329
        }
      }
    } ]
  }, {
    "id" : 59283,
    "reactomeId" : 10263267,
    "displayName" : "LOC609365",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 4567,
      "y" : 418
    },
    "minX" : 4546,
    "maxX" : 4689,
    "minY" : 398,
    "maxY" : 471,
    "prop" : {
      "x" : 4546,
      "y" : 407,
      "width" : 42,
      "height" : 23
    },
    "textPosition" : {
      "x" : 4547,
      "y" : 394
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 4588,
          "y" : 407
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 4588,
          "y" : 407
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 59282,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 4591,
          "y" : 412
        },
        "to" : {
          "x" : 4643,
          "y" : 398
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 59286,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 4591,
          "y" : 427
        },
        "to" : {
          "x" : 4689,
          "y" : 471
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 59284,
    "reactomeId" : 10238125,
    "displayName" : "Cell surface:C3b",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 4570,
      "y" : 369
    },
    "minX" : 4518,
    "maxX" : 4643,
    "minY" : 352,
    "maxY" : 398,
    "prop" : {
      "x" : 4518,
      "y" : 358,
      "width" : 104,
      "height" : 23
    },
    "textPosition" : {
      "x" : 4527,
      "y" : 346
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 4622,
          "y" : 358
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 4622,
          "y" : 358
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 59282,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 4598,
          "y" : 384
        },
        "to" : {
          "x" : 4643,
          "y" : 398
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 59285,
    "reactomeId" : 10263269,
    "displayName" : "CD46:Cell surface:C3b",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 4572,
      "y" : 467
    },
    "minX" : 4514,
    "maxX" : 4637,
    "minY" : 443,
    "maxY" : 486,
    "prop" : {
      "x" : 4514,
      "y" : 449,
      "width" : 117,
      "height" : 37
    },
    "textPosition" : {
      "x" : 4531,
      "y" : 451
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 4631,
          "y" : 449
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 4631,
          "y" : 449
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 59282,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 59287,
    "reactomeId" : 10238081,
    "displayName" : "Cell surface:C4b",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 4563,
      "y" : 518
    },
    "minX" : 4511,
    "maxX" : 4689,
    "minY" : 471,
    "maxY" : 530,
    "prop" : {
      "x" : 4511,
      "y" : 507,
      "width" : 104,
      "height" : 23
    },
    "textPosition" : {
      "x" : 4520,
      "y" : 495
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 4615,
          "y" : 507
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 4615,
          "y" : 507
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 59286,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 4593,
          "y" : 504
        },
        "to" : {
          "x" : 4689,
          "y" : 471
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 59288,
    "reactomeId" : 10263271,
    "displayName" : "CD46:Cell surface:C4b",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 4564,
      "y" : 558
    },
    "minX" : 4506,
    "maxX" : 4629,
    "minY" : 534,
    "maxY" : 577,
    "prop" : {
      "x" : 4506,
      "y" : 540,
      "width" : 117,
      "height" : 37
    },
    "textPosition" : {
      "x" : 4523,
      "y" : 542
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 4623,
          "y" : 540
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 4623,
          "y" : 540
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 59286,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 59291,
    "reactomeId" : 9691614,
    "displayName" : "C5 inhibitors",
    "schemaClass" : "CandidateSet",
    "renderableClass" : "EntitySetDrug",
    "position" : {
      "x" : 2068,
      "y" : 66
    },
    "minX" : 2027,
    "maxX" : 2138,
    "minY" : 55,
    "maxY" : 101,
    "prop" : {
      "x" : 2027,
      "y" : 55,
      "width" : 82,
      "height" : 23
    },
    "textPosition" : {
      "x" : 2035,
      "y" : 49
    },
    "bgColor" : {
      "r" : 184,
      "g" : 154,
      "b" : 230
    },
    "fgColor" : {
      "r" : 161,
      "g" : 1,
      "b" : 2
    },
    "connectors" : [ {
      "edgeId" : 59290,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 2091,
          "y" : 84
        },
        "to" : {
          "x" : 2138,
          "y" : 101
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 59292,
    "reactomeId" : 10320348,
    "displayName" : "C5:C5 inhibitors",
    "schemaClass" : "Complex",
    "renderableClass" : "ComplexDrug",
    "position" : {
      "x" : 2138,
      "y" : 155
    },
    "minX" : 2087,
    "maxX" : 2195,
    "minY" : 138,
    "maxY" : 167,
    "prop" : {
      "x" : 2087,
      "y" : 144,
      "width" : 102,
      "height" : 23
    },
    "textPosition" : {
      "x" : 2105,
      "y" : 132
    },
    "bgColor" : {
      "r" : 184,
      "g" : 154,
      "b" : 230
    },
    "fgColor" : {
      "r" : 161,
      "g" : 1,
      "b" : 2
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 2189,
          "y" : 144
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 2189,
          "y" : 144
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 59290,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 59294,
    "reactomeId" : 9957061,
    "displayName" : "C3 inhibitors",
    "schemaClass" : "CandidateSet",
    "renderableClass" : "EntitySetDrug",
    "position" : {
      "x" : 520,
      "y" : 1408
    },
    "minX" : 479,
    "maxX" : 592,
    "minY" : 1397,
    "maxY" : 1440,
    "prop" : {
      "x" : 479,
      "y" : 1397,
      "width" : 82,
      "height" : 23
    },
    "textPosition" : {
      "x" : 487,
      "y" : 1391
    },
    "bgColor" : {
      "r" : 184,
      "g" : 154,
      "b" : 230
    },
    "fgColor" : {
      "r" : 161,
      "g" : 1,
      "b" : 2
    },
    "connectors" : [ {
      "edgeId" : 59293,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 545,
          "y" : 1426
        },
        "to" : {
          "x" : 592,
          "y" : 1440
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 59295,
    "reactomeId" : 10328218,
    "displayName" : "C3:C3 inhibitors",
    "schemaClass" : "Complex",
    "renderableClass" : "ComplexDrug",
    "position" : {
      "x" : 594,
      "y" : 1513
    },
    "minX" : 543,
    "maxX" : 651,
    "minY" : 1496,
    "maxY" : 1525,
    "prop" : {
      "x" : 543,
      "y" : 1502,
      "width" : 102,
      "height" : 23
    },
    "textPosition" : {
      "x" : 561,
      "y" : 1490
    },
    "bgColor" : {
      "r" : 184,
      "g" : 154,
      "b" : 230
    },
    "fgColor" : {
      "r" : 161,
      "g" : 1,
      "b" : 2
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 645,
          "y" : 1502
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 645,
          "y" : 1502
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 59293,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 59297,
    "reactomeId" : 9957478,
    "displayName" : "vilobelimab",
    "schemaClass" : "ProteinDrug",
    "renderableClass" : "ProteinDrug",
    "position" : {
      "x" : 2447,
      "y" : 218
    },
    "minX" : 2407,
    "maxX" : 2485,
    "minY" : 207,
    "maxY" : 248,
    "prop" : {
      "x" : 2410,
      "y" : 207,
      "width" : 75,
      "height" : 23
    },
    "textPosition" : {
      "x" : 2413,
      "y" : 201
    },
    "bgColor" : {
      "r" : 184,
      "g" : 154,
      "b" : 230
    },
    "fgColor" : {
      "r" : 161,
      "g" : 1,
      "b" : 2
    },
    "connectors" : [ {
      "edgeId" : 59296,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 2431,
          "y" : 233
        },
        "to" : {
          "x" : 2407,
          "y" : 248
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 59298,
    "reactomeId" : 10328222,
    "displayName" : "C5a:vilobelimab",
    "schemaClass" : "Complex",
    "renderableClass" : "ComplexDrug",
    "position" : {
      "x" : 2443,
      "y" : 302
    },
    "minX" : 2392,
    "maxX" : 2500,
    "minY" : 285,
    "maxY" : 314,
    "prop" : {
      "x" : 2392,
      "y" : 291,
      "width" : 102,
      "height" : 23
    },
    "textPosition" : {
      "x" : 2404,
      "y" : 279
    },
    "bgColor" : {
      "r" : 184,
      "g" : 154,
      "b" : 230
    },
    "fgColor" : {
      "r" : 161,
      "g" : 1,
      "b" : 2
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 2494,
          "y" : 291
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 2494,
          "y" : 291
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 59296,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 59300,
    "reactomeId" : 9957436,
    "displayName" : "C5AR1 antagonists",
    "schemaClass" : "CandidateSet",
    "renderableClass" : "EntitySetDrug",
    "position" : {
      "x" : 2464,
      "y" : 346
    },
    "minX" : 2405,
    "maxX" : 2523,
    "minY" : 335,
    "maxY" : 379,
    "prop" : {
      "x" : 2405,
      "y" : 335,
      "width" : 118,
      "height" : 23
    },
    "textPosition" : {
      "x" : 2422,
      "y" : 329
    },
    "bgColor" : {
      "r" : 184,
      "g" : 154,
      "b" : 230
    },
    "fgColor" : {
      "r" : 161,
      "g" : 1,
      "b" : 2
    },
    "connectors" : [ {
      "edgeId" : 59299,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 2443,
          "y" : 364
        },
        "to" : {
          "x" : 2406,
          "y" : 379
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 59301,
    "reactomeId" : 10328226,
    "displayName" : "C5AR1:C5AR1 antagonist",
    "schemaClass" : "Complex",
    "renderableClass" : "ComplexDrug",
    "position" : {
      "x" : 2339,
      "y" : 454
    },
    "minX" : 2291,
    "maxX" : 2394,
    "minY" : 430,
    "maxY" : 473,
    "prop" : {
      "x" : 2291,
      "y" : 436,
      "width" : 97,
      "height" : 37
    },
    "textPosition" : {
      "x" : 2291,
      "y" : 438
    },
    "bgColor" : {
      "r" : 184,
      "g" : 154,
      "b" : 230
    },
    "fgColor" : {
      "r" : 161,
      "g" : 1,
      "b" : 2
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 2388,
          "y" : 436
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 2388,
          "y" : 436
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 59299,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 59070,
    "reactomeId" : 10239501,
    "displayName" : "Antigen:IgG:C1Q:2xC1R:2xC1S",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 676,
      "y" : 255
    },
    "minX" : 622,
    "maxX" : 786,
    "minY" : 231,
    "maxY" : 287,
    "prop" : {
      "x" : 622,
      "y" : 237,
      "width" : 108,
      "height" : 37
    },
    "textPosition" : {
      "x" : 634,
      "y" : 225
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 730,
          "y" : 237
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 730,
          "y" : 237
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 59069,
      "type" : "INPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 59069,
      "type" : "CATALYST",
      "segments" : [ {
        "from" : {
          "x" : 733,
          "y" : 271
        },
        "to" : {
          "x" : 782,
          "y" : 287
        }
      }, {
        "from" : {
          "x" : 782,
          "y" : 287
        },
        "to" : {
          "x" : 782,
          "y" : 271
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 782,
          "y" : 267
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 782,
          "y" : 267
        }
      }
    } ]
  }, {
    "id" : 59071,
    "reactomeId" : 10239513,
    "displayName" : "Antigen:IgG:C1Q:2x Activated C1R:2xC1S",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 881,
      "y" : 256
    },
    "minX" : 816,
    "maxX" : 983,
    "minY" : 232,
    "maxY" : 292,
    "prop" : {
      "x" : 816,
      "y" : 238,
      "width" : 131,
      "height" : 37
    },
    "textPosition" : {
      "x" : 816,
      "y" : 226
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 947,
          "y" : 238
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 947,
          "y" : 238
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 59069,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 59073,
      "type" : "INPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 59073,
      "type" : "CATALYST",
      "segments" : [ {
        "from" : {
          "x" : 931,
          "y" : 278
        },
        "to" : {
          "x" : 979,
          "y" : 292
        }
      }, {
        "from" : {
          "x" : 979,
          "y" : 292
        },
        "to" : {
          "x" : 979,
          "y" : 272
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 979,
          "y" : 268
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 979,
          "y" : 268
        }
      }
    } ]
  }, {
    "id" : 59072,
    "reactomeId" : 10239524,
    "displayName" : "C-reactive protein pentamer:phosphocholine:C1Q",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 781,
      "y" : 181
    },
    "minX" : 717,
    "maxX" : 851,
    "minY" : 150,
    "maxY" : 246,
    "prop" : {
      "x" : 717,
      "y" : 156,
      "width" : 128,
      "height" : 51
    },
    "textPosition" : {
      "x" : 719,
      "y" : 144
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 845,
          "y" : 156
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 845,
          "y" : 156
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 59069,
      "type" : "ACTIVATOR",
      "segments" : [ {
        "from" : {
          "x" : 781,
          "y" : 210
        },
        "to" : {
          "x" : 782,
          "y" : 246
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 778,
          "y" : 239
        },
        "b" : {
          "x" : 782,
          "y" : 246
        },
        "c" : {
          "x" : 786,
          "y" : 239
        },
        "type" : "ARROW",
        "empty" : true,
        "centre" : {
          "x" : 786,
          "y" : 239
        }
      }
    } ]
  }, {
    "id" : 59074,
    "reactomeId" : 10239539,
    "displayName" : "Antigen:IgG:C1Q:2x Activated C1R:2x Activated C1S",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 1076,
      "y" : 258
    },
    "minX" : 1013,
    "maxX" : 1146,
    "minY" : 203,
    "maxY" : 284,
    "prop" : {
      "x" : 1013,
      "y" : 233,
      "width" : 127,
      "height" : 51
    },
    "textPosition" : {
      "x" : 1011,
      "y" : 235
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1140,
          "y" : 233
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1140,
          "y" : 233
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 59073,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 59240,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1091,
          "y" : 230
        },
        "to" : {
          "x" : 1110,
          "y" : 203
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 59076,
    "reactomeId" : 10238081,
    "displayName" : "Cell surface:C4b",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 1859,
      "y" : 256
    },
    "minX" : 1807,
    "maxX" : 1917,
    "minY" : 218,
    "maxY" : 268,
    "prop" : {
      "x" : 1807,
      "y" : 245,
      "width" : 104,
      "height" : 23
    },
    "textPosition" : {
      "x" : 1816,
      "y" : 233
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1911,
          "y" : 245
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1911,
          "y" : 245
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 59075,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1869,
          "y" : 242
        },
        "to" : {
          "x" : 1893,
          "y" : 218
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 59129,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 59077,
    "reactomeId" : 10238061,
    "displayName" : "C2",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 1819,
      "y" : 37
    },
    "minX" : 1803,
    "maxX" : 1893,
    "minY" : 20,
    "maxY" : 218,
    "prop" : {
      "x" : 1803,
      "y" : 26,
      "width" : 32,
      "height" : 23
    },
    "textPosition" : {
      "x" : 1807,
      "y" : 27
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1835,
          "y" : 26
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1835,
          "y" : 26
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 59075,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1823,
          "y" : 52
        },
        "to" : {
          "x" : 1893,
          "y" : 218
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 59078,
    "reactomeId" : 10238083,
    "displayName" : "Cell surface:C4b:C2a",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 1967,
      "y" : 256
    },
    "minX" : 1902,
    "maxX" : 2090,
    "minY" : 219,
    "maxY" : 268,
    "prop" : {
      "x" : 1902,
      "y" : 245,
      "width" : 131,
      "height" : 23
    },
    "textPosition" : {
      "x" : 1911,
      "y" : 233
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 2033,
          "y" : 245
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 2033,
          "y" : 245
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 59075,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 59106,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 2005,
          "y" : 242
        },
        "to" : {
          "x" : 2090,
          "y" : 219
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 59080,
    "reactomeId" : 10238094,
    "displayName" : "Complement factor 3",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 613,
      "y" : 1258
    },
    "minX" : 548,
    "maxX" : 2094,
    "minY" : 1189,
    "maxY" : 1446,
    "prop" : {
      "x" : 548,
      "y" : 1247,
      "width" : 131,
      "height" : 23
    },
    "textPosition" : {
      "x" : 548,
      "y" : 1235
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 679,
          "y" : 1247
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 679,
          "y" : 1247
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 59293,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 611,
          "y" : 1273
        },
        "to" : {
          "x" : 592,
          "y" : 1440
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 59079,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 635,
          "y" : 1273
        },
        "to" : {
          "x" : 854,
          "y" : 1381
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 59094,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 617,
          "y" : 1273
        },
        "to" : {
          "x" : 693,
          "y" : 1446
        }
      }, {
        "from" : {
          "x" : 693,
          "y" : 1446
        },
        "to" : {
          "x" : 2073,
          "y" : 1440
        }
      }, {
        "from" : {
          "x" : 2073,
          "y" : 1440
        },
        "to" : {
          "x" : 2094,
          "y" : 1189
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 59097,
      "type" : "INPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 59101,
      "type" : "INPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 59081,
    "reactomeId" : 109276,
    "displayName" : "H2O",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 796,
      "y" : 1403
    },
    "minX" : 775,
    "maxX" : 854,
    "minY" : 1381,
    "maxY" : 1419,
    "prop" : {
      "x" : 775,
      "y" : 1388,
      "width" : 43,
      "height" : 31
    },
    "textPosition" : {
      "x" : 779,
      "y" : 1393
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 813,
          "y" : 1393
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 813,
          "y" : 1393
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 59079,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 821,
          "y" : 1394
        },
        "to" : {
          "x" : 854,
          "y" : 1381
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ],
    "trivial" : true
  }, {
    "id" : 59082,
    "reactomeId" : 10238105,
    "displayName" : "C3(H2O)",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 1279,
      "y" : 1381
    },
    "minX" : 1250,
    "maxX" : 1337,
    "minY" : 1294,
    "maxY" : 1393,
    "prop" : {
      "x" : 1250,
      "y" : 1370,
      "width" : 59,
      "height" : 23
    },
    "textPosition" : {
      "x" : 1257,
      "y" : 1358
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1309,
          "y" : 1370
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1309,
          "y" : 1370
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 59079,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 59083,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1286,
          "y" : 1367
        },
        "to" : {
          "x" : 1337,
          "y" : 1294
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 59084,
    "reactomeId" : 10239626,
    "displayName" : "CFB",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 1271,
      "y" : 1224
    },
    "minX" : 1229,
    "maxX" : 1345,
    "minY" : 1196,
    "maxY" : 1294,
    "prop" : {
      "x" : 1229,
      "y" : 1213,
      "width" : 85,
      "height" : 23
    },
    "textPosition" : {
      "x" : 1256,
      "y" : 1214
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1314,
          "y" : 1213
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1314,
          "y" : 1213
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 59083,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1281,
          "y" : 1239
        },
        "to" : {
          "x" : 1337,
          "y" : 1294
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 59102,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1301,
          "y" : 1210
        },
        "to" : {
          "x" : 1345,
          "y" : 1196
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 59085,
    "reactomeId" : 10239628,
    "displayName" : "C3(H2O):CFB",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 1457,
      "y" : 1294
    },
    "minX" : 1415,
    "maxX" : 1505,
    "minY" : 1277,
    "maxY" : 1306,
    "prop" : {
      "x" : 1415,
      "y" : 1283,
      "width" : 84,
      "height" : 23
    },
    "textPosition" : {
      "x" : 1425,
      "y" : 1271
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1499,
          "y" : 1283
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1499,
          "y" : 1283
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 59083,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 59086,
      "type" : "INPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 59087,
    "reactomeId" : 10239632,
    "displayName" : "CFB",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 1708,
      "y" : 1254
    },
    "minX" : 1624,
    "maxX" : 1757,
    "minY" : 1198,
    "maxY" : 1295,
    "prop" : {
      "x" : 1666,
      "y" : 1243,
      "width" : 85,
      "height" : 23
    },
    "textPosition" : {
      "x" : 1693,
      "y" : 1244
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1751,
          "y" : 1243
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1751,
          "y" : 1243
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 59086,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 1684,
          "y" : 1269
        },
        "to" : {
          "x" : 1624,
          "y" : 1295
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 1679,
          "y" : 1275
        },
        "b" : {
          "x" : 1684,
          "y" : 1269
        },
        "c" : {
          "x" : 1676,
          "y" : 1268
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 1676,
          "y" : 1268
        }
      }
    }, {
      "edgeId" : 59105,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 1699,
          "y" : 1240
        },
        "to" : {
          "x" : 1667,
          "y" : 1198
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 1692,
          "y" : 1237
        },
        "b" : {
          "x" : 1699,
          "y" : 1240
        },
        "c" : {
          "x" : 1698,
          "y" : 1232
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 1698,
          "y" : 1232
        }
      }
    } ]
  }, {
    "id" : 59088,
    "reactomeId" : 10238111,
    "displayName" : "C3(H2O):Bb",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 1706,
      "y" : 1328
    },
    "minX" : 740,
    "maxX" : 1751,
    "minY" : 1275,
    "maxY" : 1340,
    "prop" : {
      "x" : 1667,
      "y" : 1317,
      "width" : 78,
      "height" : 23
    },
    "textPosition" : {
      "x" : 1674,
      "y" : 1305
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1745,
          "y" : 1317
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1745,
          "y" : 1317
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 59086,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 1677,
          "y" : 1314
        },
        "to" : {
          "x" : 1624,
          "y" : 1295
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 1669,
          "y" : 1315
        },
        "b" : {
          "x" : 1677,
          "y" : 1314
        },
        "c" : {
          "x" : 1672,
          "y" : 1308
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 1672,
          "y" : 1308
        }
      }
    }, {
      "edgeId" : 59101,
      "type" : "CATALYST",
      "segments" : [ {
        "from" : {
          "x" : 1664,
          "y" : 1327
        },
        "to" : {
          "x" : 745,
          "y" : 1310
        }
      }, {
        "from" : {
          "x" : 745,
          "y" : 1310
        },
        "to" : {
          "x" : 744,
          "y" : 1283
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 744,
          "y" : 1279
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 744,
          "y" : 1279
        }
      }
    } ]
  }, {
    "id" : 59089,
    "reactomeId" : 10239636,
    "displayName" : "CFD",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 1570,
      "y" : 1230
    },
    "minX" : 1509,
    "maxX" : 1638,
    "minY" : 1190,
    "maxY" : 1286,
    "prop" : {
      "x" : 1509,
      "y" : 1212,
      "width" : 123,
      "height" : 37
    },
    "textPosition" : {
      "x" : 1554,
      "y" : 1220
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1632,
          "y" : 1212
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1632,
          "y" : 1212
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 59086,
      "type" : "CATALYST",
      "segments" : [ {
        "from" : {
          "x" : 1569,
          "y" : 1255
        },
        "to" : {
          "x" : 1568,
          "y" : 1278
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 1568,
          "y" : 1282
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1568,
          "y" : 1282
        }
      }
    }, {
      "edgeId" : 59105,
      "type" : "CATALYST",
      "segments" : [ {
        "from" : {
          "x" : 1573,
          "y" : 1206
        },
        "to" : {
          "x" : 1575,
          "y" : 1198
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 1577,
          "y" : 1194
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1577,
          "y" : 1194
        }
      }
    } ]
  }, {
    "id" : 59091,
    "reactomeId" : 10238115,
    "displayName" : "Cell surface:C3b:Bb",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 1704,
      "y" : 1165
    },
    "minX" : 1643,
    "maxX" : 1808,
    "minY" : 1148,
    "maxY" : 1198,
    "prop" : {
      "x" : 1643,
      "y" : 1154,
      "width" : 123,
      "height" : 23
    },
    "textPosition" : {
      "x" : 1648,
      "y" : 1142
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1766,
          "y" : 1154
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1766,
          "y" : 1154
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 59090,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1769,
          "y" : 1172
        },
        "to" : {
          "x" : 1808,
          "y" : 1178
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 59105,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 1691,
          "y" : 1180
        },
        "to" : {
          "x" : 1667,
          "y" : 1198
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 1688,
          "y" : 1187
        },
        "b" : {
          "x" : 1691,
          "y" : 1180
        },
        "c" : {
          "x" : 1683,
          "y" : 1181
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 1683,
          "y" : 1181
        }
      }
    } ]
  }, {
    "id" : 59092,
    "reactomeId" : 10238121,
    "displayName" : "Properdin oligomer",
    "schemaClass" : "Polymer",
    "renderableClass" : "Entity",
    "position" : {
      "x" : 1795,
      "y" : 1210
    },
    "minX" : 1735,
    "maxX" : 1855,
    "minY" : 1178,
    "maxY" : 1222,
    "prop" : {
      "x" : 1735,
      "y" : 1199,
      "width" : 120,
      "height" : 23
    },
    "textPosition" : {
      "x" : 1758,
      "y" : 1193
    },
    "connectors" : [ {
      "edgeId" : 59090,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1799,
          "y" : 1196
        },
        "to" : {
          "x" : 1808,
          "y" : 1178
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 59093,
    "reactomeId" : 10238123,
    "displayName" : "Cell surface:C3b:Bb:Properdin",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 2020,
      "y" : 1160
    },
    "minX" : 1957,
    "maxX" : 2132,
    "minY" : 1136,
    "maxY" : 1189,
    "prop" : {
      "x" : 1957,
      "y" : 1142,
      "width" : 127,
      "height" : 37
    },
    "textPosition" : {
      "x" : 1964,
      "y" : 1144
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 2084,
          "y" : 1142
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 2084,
          "y" : 1142
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 59090,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 59094,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 2067,
          "y" : 1182
        },
        "to" : {
          "x" : 2094,
          "y" : 1189
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 59094,
      "type" : "CATALYST",
      "segments" : [ {
        "from" : {
          "x" : 2087,
          "y" : 1157
        },
        "to" : {
          "x" : 2127,
          "y" : 1156
        }
      }, {
        "from" : {
          "x" : 2127,
          "y" : 1156
        },
        "to" : {
          "x" : 2128,
          "y" : 1173
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 2128,
          "y" : 1177
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 2128,
          "y" : 1177
        }
      }
    } ]
  }, {
    "id" : 59095,
    "reactomeId" : 10239560,
    "displayName" : "C3b:Bb:C3b:Properdin",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 2229,
      "y" : 1159
    },
    "minX" : 2163,
    "maxX" : 2277,
    "minY" : 1135,
    "maxY" : 1189,
    "prop" : {
      "x" : 2187,
      "y" : 1141,
      "width" : 84,
      "height" : 37
    },
    "textPosition" : {
      "x" : 2187,
      "y" : 1143
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 2271,
          "y" : 1141
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 2271,
          "y" : 1141
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 59094,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 2188,
          "y" : 1181
        },
        "to" : {
          "x" : 2163,
          "y" : 1189
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 2183,
          "y" : 1187
        },
        "b" : {
          "x" : 2188,
          "y" : 1181
        },
        "c" : {
          "x" : 2180,
          "y" : 1179
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 2180,
          "y" : 1179
        }
      }
    } ]
  }, {
    "id" : 59096,
    "reactomeId" : 10238100,
    "displayName" : "C3",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 2205,
      "y" : 1226
    },
    "minX" : 2163,
    "maxX" : 2227,
    "minY" : 1189,
    "maxY" : 1238,
    "prop" : {
      "x" : 2189,
      "y" : 1215,
      "width" : 32,
      "height" : 23
    },
    "textPosition" : {
      "x" : 2193,
      "y" : 1216
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 2221,
          "y" : 1215
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 2221,
          "y" : 1215
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 59094,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 2191,
          "y" : 1212
        },
        "to" : {
          "x" : 2163,
          "y" : 1189
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 2183,
          "y" : 1211
        },
        "b" : {
          "x" : 2191,
          "y" : 1212
        },
        "c" : {
          "x" : 2188,
          "y" : 1205
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 2188,
          "y" : 1205
        }
      }
    } ]
  }, {
    "id" : 59098,
    "reactomeId" : 10238100,
    "displayName" : "C3",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 896,
      "y" : 1221
    },
    "minX" : 785,
    "maxX" : 919,
    "minY" : 1190,
    "maxY" : 1267,
    "prop" : {
      "x" : 880,
      "y" : 1210,
      "width" : 32,
      "height" : 23
    },
    "textPosition" : {
      "x" : 884,
      "y" : 1211
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 912,
          "y" : 1210
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 912,
          "y" : 1210
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 59097,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 877,
          "y" : 1223
        },
        "to" : {
          "x" : 785,
          "y" : 1238
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 871,
          "y" : 1228
        },
        "b" : {
          "x" : 877,
          "y" : 1223
        },
        "c" : {
          "x" : 870,
          "y" : 1220
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 870,
          "y" : 1220
        }
      }
    }, {
      "edgeId" : 59101,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 877,
          "y" : 1227
        },
        "to" : {
          "x" : 790,
          "y" : 1267
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 872,
          "y" : 1234
        },
        "b" : {
          "x" : 877,
          "y" : 1227
        },
        "c" : {
          "x" : 869,
          "y" : 1226
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 869,
          "y" : 1226
        }
      }
    }, {
      "edgeId" : 59237,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 904,
          "y" : 1207
        },
        "to" : {
          "x" : 919,
          "y" : 1190
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 59099,
    "reactomeId" : 10238098,
    "displayName" : "C3b",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 890,
      "y" : 1277
    },
    "minX" : 785,
    "maxX" : 1145,
    "minY" : 1207,
    "maxY" : 1289,
    "prop" : {
      "x" : 874,
      "y" : 1266,
      "width" : 33,
      "height" : 23
    },
    "textPosition" : {
      "x" : 874,
      "y" : 1268
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 907,
          "y" : 1266
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 907,
          "y" : 1266
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 59097,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 871,
          "y" : 1270
        },
        "to" : {
          "x" : 785,
          "y" : 1238
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 863,
          "y" : 1271
        },
        "b" : {
          "x" : 871,
          "y" : 1270
        },
        "c" : {
          "x" : 866,
          "y" : 1264
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 866,
          "y" : 1264
        }
      }
    }, {
      "edgeId" : 59101,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 871,
          "y" : 1275
        },
        "to" : {
          "x" : 790,
          "y" : 1267
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 864,
          "y" : 1278
        },
        "b" : {
          "x" : 871,
          "y" : 1275
        },
        "c" : {
          "x" : 864,
          "y" : 1270
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 864,
          "y" : 1270
        }
      }
    }, {
      "edgeId" : 59132,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 910,
          "y" : 1272
        },
        "to" : {
          "x" : 1145,
          "y" : 1207
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 59100,
    "reactomeId" : 10238129,
    "displayName" : "C3 convertases",
    "schemaClass" : "DefinedSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 746,
      "y" : 1160
    },
    "minX" : 698,
    "maxX" : 795,
    "minY" : 1149,
    "maxY" : 1230,
    "prop" : {
      "x" : 698,
      "y" : 1149,
      "width" : 97,
      "height" : 23
    },
    "textPosition" : {
      "x" : 704,
      "y" : 1143
    },
    "connectors" : [ {
      "edgeId" : 59097,
      "type" : "CATALYST",
      "segments" : [ {
        "from" : {
          "x" : 745,
          "y" : 1178
        },
        "to" : {
          "x" : 743,
          "y" : 1214
        }
      }, {
        "from" : {
          "x" : 743,
          "y" : 1214
        },
        "to" : {
          "x" : 743,
          "y" : 1222
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 744,
          "y" : 1226
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 744,
          "y" : 1226
        }
      }
    } ]
  }, {
    "id" : 59103,
    "reactomeId" : 10238125,
    "displayName" : "Cell surface:C3b",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 1271,
      "y" : 1168
    },
    "minX" : 1219,
    "maxX" : 2368,
    "minY" : 1075,
    "maxY" : 1196,
    "prop" : {
      "x" : 1219,
      "y" : 1157,
      "width" : 104,
      "height" : 23
    },
    "textPosition" : {
      "x" : 1228,
      "y" : 1145
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1323,
          "y" : 1157
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1323,
          "y" : 1157
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 59268,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1297,
          "y" : 1154
        },
        "to" : {
          "x" : 1486,
          "y" : 1076
        }
      }, {
        "from" : {
          "x" : 1486,
          "y" : 1076
        },
        "to" : {
          "x" : 2368,
          "y" : 1075
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 59102,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1301,
          "y" : 1183
        },
        "to" : {
          "x" : 1345,
          "y" : 1196
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 59132,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 59104,
    "reactomeId" : 10241006,
    "displayName" : "Cell surface:C3b:CFB",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 1437,
      "y" : 1167
    },
    "minX" : 1373,
    "maxX" : 1508,
    "minY" : 1150,
    "maxY" : 1179,
    "prop" : {
      "x" : 1373,
      "y" : 1156,
      "width" : 129,
      "height" : 23
    },
    "textPosition" : {
      "x" : 1381,
      "y" : 1144
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1502,
          "y" : 1156
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1502,
          "y" : 1156
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 59102,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 59105,
      "type" : "INPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 59107,
    "reactomeId" : 10238125,
    "displayName" : "Cell surface:C3b",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 2074,
      "y" : 258
    },
    "minX" : 2022,
    "maxX" : 2132,
    "minY" : 219,
    "maxY" : 270,
    "prop" : {
      "x" : 2022,
      "y" : 247,
      "width" : 104,
      "height" : 23
    },
    "textPosition" : {
      "x" : 2031,
      "y" : 235
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 2126,
          "y" : 247
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 2126,
          "y" : 247
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 59106,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 2078,
          "y" : 244
        },
        "to" : {
          "x" : 2090,
          "y" : 219
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 59108,
    "reactomeId" : 10238127,
    "displayName" : "C4b:C2a:C3b",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 2171,
      "y" : 258
    },
    "minX" : 2127,
    "maxX" : 2221,
    "minY" : 241,
    "maxY" : 270,
    "prop" : {
      "x" : 2127,
      "y" : 247,
      "width" : 88,
      "height" : 23
    },
    "textPosition" : {
      "x" : 2127,
      "y" : 249
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 2215,
          "y" : 247
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 2215,
          "y" : 247
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 59106,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 59110,
    "reactomeId" : 10239552,
    "displayName" : "C5",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 2200,
      "y" : 76
    },
    "minX" : 2138,
    "maxX" : 2219,
    "minY" : 59,
    "maxY" : 101,
    "prop" : {
      "x" : 2188,
      "y" : 65,
      "width" : 25,
      "height" : 23
    },
    "textPosition" : {
      "x" : 2188,
      "y" : 67
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 2213,
          "y" : 65
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 2213,
          "y" : 65
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 59264,
      "type" : "INPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 59290,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 2185,
          "y" : 81
        },
        "to" : {
          "x" : 2138,
          "y" : 101
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 59109,
      "type" : "INPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 59111,
    "reactomeId" : 10239554,
    "displayName" : "C5",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 2378,
      "y" : 214
    },
    "minX" : 2362,
    "maxX" : 2407,
    "minY" : 149,
    "maxY" : 329,
    "prop" : {
      "x" : 2362,
      "y" : 203,
      "width" : 32,
      "height" : 23
    },
    "textPosition" : {
      "x" : 2366,
      "y" : 204
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 2394,
          "y" : 203
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 2394,
          "y" : 203
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 59296,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 2387,
          "y" : 229
        },
        "to" : {
          "x" : 2407,
          "y" : 248
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 59109,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 2377,
          "y" : 200
        },
        "to" : {
          "x" : 2374,
          "y" : 149
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 2373,
          "y" : 193
        },
        "b" : {
          "x" : 2377,
          "y" : 200
        },
        "c" : {
          "x" : 2381,
          "y" : 193
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 2381,
          "y" : 193
        }
      }
    }, {
      "edgeId" : 59258,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 2377,
          "y" : 229
        },
        "to" : {
          "x" : 2377,
          "y" : 329
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 59112,
    "reactomeId" : 10239558,
    "displayName" : "C5b",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 2507,
      "y" : 150
    },
    "minX" : 2374,
    "maxX" : 2577,
    "minY" : 133,
    "maxY" : 162,
    "prop" : {
      "x" : 2491,
      "y" : 139,
      "width" : 33,
      "height" : 23
    },
    "textPosition" : {
      "x" : 2491,
      "y" : 141
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 2524,
          "y" : 139
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 2524,
          "y" : 139
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 59109,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 2488,
          "y" : 149
        },
        "to" : {
          "x" : 2374,
          "y" : 149
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 2481,
          "y" : 153
        },
        "b" : {
          "x" : 2488,
          "y" : 149
        },
        "c" : {
          "x" : 2481,
          "y" : 145
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 2481,
          "y" : 145
        }
      }
    }, {
      "edgeId" : 59114,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 2527,
          "y" : 147
        },
        "to" : {
          "x" : 2577,
          "y" : 141
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 59113,
    "reactomeId" : 10239562,
    "displayName" : "C5 convertases",
    "schemaClass" : "DefinedSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 2276,
      "y" : 256
    },
    "minX" : 2228,
    "maxX" : 2325,
    "minY" : 156,
    "maxY" : 268,
    "prop" : {
      "x" : 2228,
      "y" : 245,
      "width" : 97,
      "height" : 23
    },
    "textPosition" : {
      "x" : 2234,
      "y" : 239
    },
    "connectors" : [ {
      "edgeId" : 59109,
      "type" : "CATALYST",
      "segments" : [ {
        "from" : {
          "x" : 2280,
          "y" : 239
        },
        "to" : {
          "x" : 2312,
          "y" : 164
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 2313,
          "y" : 160
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 2313,
          "y" : 160
        }
      }
    } ]
  }, {
    "id" : 59115,
    "reactomeId" : 10239569,
    "displayName" : "C6",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 2541,
      "y" : 109
    },
    "minX" : 2529,
    "maxX" : 2577,
    "minY" : 92,
    "maxY" : 141,
    "prop" : {
      "x" : 2529,
      "y" : 98,
      "width" : 25,
      "height" : 23
    },
    "textPosition" : {
      "x" : 2529,
      "y" : 99
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 2554,
          "y" : 98
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 2554,
          "y" : 98
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 59114,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 2557,
          "y" : 120
        },
        "to" : {
          "x" : 2577,
          "y" : 141
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 59116,
    "reactomeId" : 10239571,
    "displayName" : "C5b:C6",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 2588,
      "y" : 183
    },
    "minX" : 2550,
    "maxX" : 2621,
    "minY" : 166,
    "maxY" : 213,
    "prop" : {
      "x" : 2562,
      "y" : 172,
      "width" : 53,
      "height" : 23
    },
    "textPosition" : {
      "x" : 2562,
      "y" : 174
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 2615,
          "y" : 172
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 2615,
          "y" : 172
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 59114,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 59117,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 2573,
          "y" : 198
        },
        "to" : {
          "x" : 2550,
          "y" : 213
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 59118,
    "reactomeId" : 10239577,
    "displayName" : "C7",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 2515,
      "y" : 194
    },
    "minX" : 2503,
    "maxX" : 2550,
    "minY" : 177,
    "maxY" : 213,
    "prop" : {
      "x" : 2503,
      "y" : 183,
      "width" : 25,
      "height" : 23
    },
    "textPosition" : {
      "x" : 2503,
      "y" : 184
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 2528,
          "y" : 183
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 2528,
          "y" : 183
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 59117,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 2531,
          "y" : 200
        },
        "to" : {
          "x" : 2550,
          "y" : 213
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 59119,
    "reactomeId" : 10239579,
    "displayName" : "C5b:C6:C7",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 2554,
      "y" : 313
    },
    "minX" : 2518,
    "maxX" : 2597,
    "minY" : 296,
    "maxY" : 376,
    "prop" : {
      "x" : 2518,
      "y" : 302,
      "width" : 73,
      "height" : 23
    },
    "textPosition" : {
      "x" : 2518,
      "y" : 304
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 2591,
          "y" : 302
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 2591,
          "y" : 302
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 59232,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 2555,
          "y" : 328
        },
        "to" : {
          "x" : 2563,
          "y" : 376
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 59117,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 59121,
      "type" : "INPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 59120,
    "reactomeId" : 10239609,
    "displayName" : "CLU:C5b:C6:C7, C8, C9",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 2616,
      "y" : 641
    },
    "minX" : 2369,
    "maxX" : 2713,
    "minY" : 238,
    "maxY" : 867,
    "prop" : {
      "x" : 2551,
      "y" : 623,
      "width" : 131,
      "height" : 37
    },
    "textPosition" : {
      "x" : 2551,
      "y" : 625
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 2682,
          "y" : 623
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 2682,
          "y" : 623
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 59117,
      "type" : "INHIBITOR",
      "segments" : [ {
        "from" : {
          "x" : 2634,
          "y" : 620
        },
        "to" : {
          "x" : 2712,
          "y" : 547
        }
      }, {
        "from" : {
          "x" : 2712,
          "y" : 547
        },
        "to" : {
          "x" : 2713,
          "y" : 294
        }
      }, {
        "from" : {
          "x" : 2713,
          "y" : 294
        },
        "to" : {
          "x" : 2559,
          "y" : 242
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 2558,
          "y" : 246
        },
        "b" : {
          "x" : 2560,
          "y" : 238
        },
        "c" : {
          "x" : 2559,
          "y" : 242
        },
        "type" : "STOP",
        "centre" : {
          "x" : 2559,
          "y" : 242
        }
      }
    }, {
      "edgeId" : 59121,
      "type" : "INHIBITOR",
      "segments" : [ {
        "from" : {
          "x" : 2599,
          "y" : 620
        },
        "to" : {
          "x" : 2489,
          "y" : 499
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 2486,
          "y" : 502
        },
        "b" : {
          "x" : 2492,
          "y" : 496
        },
        "c" : {
          "x" : 2489,
          "y" : 499
        },
        "type" : "STOP",
        "centre" : {
          "x" : 2489,
          "y" : 499
        }
      }
    }, {
      "edgeId" : 59122,
      "type" : "INHIBITOR",
      "segments" : [ {
        "from" : {
          "x" : 2548,
          "y" : 651
        },
        "to" : {
          "x" : 2370,
          "y" : 681
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 2369,
          "y" : 677
        },
        "b" : {
          "x" : 2371,
          "y" : 685
        },
        "c" : {
          "x" : 2370,
          "y" : 681
        },
        "type" : "STOP",
        "centre" : {
          "x" : 2370,
          "y" : 681
        }
      }
    }, {
      "edgeId" : 59126,
      "type" : "INHIBITOR",
      "segments" : [ {
        "from" : {
          "x" : 2616,
          "y" : 663
        },
        "to" : {
          "x" : 2619,
          "y" : 739
        }
      }, {
        "from" : {
          "x" : 2619,
          "y" : 739
        },
        "to" : {
          "x" : 2442,
          "y" : 864
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 2440,
          "y" : 861
        },
        "b" : {
          "x" : 2444,
          "y" : 867
        },
        "c" : {
          "x" : 2442,
          "y" : 864
        },
        "type" : "STOP",
        "centre" : {
          "x" : 2442,
          "y" : 864
        }
      }
    }, {
      "edgeId" : 59261,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 59123,
    "reactomeId" : 10239579,
    "displayName" : "C5b:C6:C7",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 2329,
      "y" : 501
    },
    "minX" : 2293,
    "maxX" : 2372,
    "minY" : 484,
    "maxY" : 546,
    "prop" : {
      "x" : 2293,
      "y" : 490,
      "width" : 73,
      "height" : 23
    },
    "textPosition" : {
      "x" : 2293,
      "y" : 492
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 2366,
          "y" : 490
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 2366,
          "y" : 490
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 59122,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 2337,
          "y" : 516
        },
        "to" : {
          "x" : 2362,
          "y" : 546
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 59124,
    "reactomeId" : 10239601,
    "displayName" : "C8",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 2384,
      "y" : 534
    },
    "minX" : 2362,
    "maxX" : 2427,
    "minY" : 517,
    "maxY" : 568,
    "prop" : {
      "x" : 2372,
      "y" : 523,
      "width" : 25,
      "height" : 23
    },
    "textPosition" : {
      "x" : 2372,
      "y" : 525
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 2397,
          "y" : 523
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 2397,
          "y" : 523
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 59228,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 2400,
          "y" : 543
        },
        "to" : {
          "x" : 2427,
          "y" : 568
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 59122,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 2369,
          "y" : 540
        },
        "to" : {
          "x" : 2362,
          "y" : 546
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 59125,
    "reactomeId" : 10239616,
    "displayName" : "C5b:C6:C7:C8",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 2338,
      "y" : 730
    },
    "minX" : 2292,
    "maxX" : 2438,
    "minY" : 713,
    "maxY" : 810,
    "prop" : {
      "x" : 2292,
      "y" : 719,
      "width" : 93,
      "height" : 23
    },
    "textPosition" : {
      "x" : 2292,
      "y" : 721
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 2385,
          "y" : 719
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 2385,
          "y" : 719
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 59122,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 59126,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 2352,
          "y" : 745
        },
        "to" : {
          "x" : 2438,
          "y" : 810
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 59127,
    "reactomeId" : 10239605,
    "displayName" : "C9",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 2553,
      "y" : 728
    },
    "minX" : 2438,
    "maxX" : 2692,
    "minY" : 657,
    "maxY" : 810,
    "prop" : {
      "x" : 2513,
      "y" : 717,
      "width" : 80,
      "height" : 23
    },
    "textPosition" : {
      "x" : 2541,
      "y" : 718
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 2593,
          "y" : 717
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 2593,
          "y" : 717
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 59224,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 2575,
          "y" : 714
        },
        "to" : {
          "x" : 2692,
          "y" : 657
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 59126,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 2536,
          "y" : 743
        },
        "to" : {
          "x" : 2438,
          "y" : 810
        }
      } ],
      "stoichiometry" : {
        "value" : 12,
        "shape" : {
          "a" : {
            "x" : 2481,
            "y" : 770
          },
          "b" : {
            "x" : 2493,
            "y" : 782
          },
          "type" : "BOX",
          "empty" : true,
          "centre" : {
            "x" : 2487,
            "y" : 776
          }
        }
      }
    } ]
  }, {
    "id" : 59128,
    "reactomeId" : 10239620,
    "displayName" : "Membrane Attack Complex",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 2327,
      "y" : 938
    },
    "minX" : 2270,
    "maxX" : 2391,
    "minY" : 914,
    "maxY" : 957,
    "prop" : {
      "x" : 2270,
      "y" : 920,
      "width" : 115,
      "height" : 37
    },
    "textPosition" : {
      "x" : 2275,
      "y" : 922
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 2385,
          "y" : 920
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 2385,
          "y" : 920
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 59126,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 59130,
    "reactomeId" : 10263335,
    "displayName" : "C4A(20-675):C4A(1454-1744):S-(L-isoglutamyl)-L-cysteine-C4A(757-1446)",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 1763,
      "y" : 127
    },
    "minX" : 1747,
    "maxX" : 1786,
    "minY" : 110,
    "maxY" : 218,
    "prop" : {
      "x" : 1747,
      "y" : 116,
      "width" : 33,
      "height" : 23
    },
    "textPosition" : {
      "x" : 1747,
      "y" : -37
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1780,
          "y" : 116
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1780,
          "y" : 116
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 59129,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1765,
          "y" : 145
        },
        "to" : {
          "x" : 1782,
          "y" : 218
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 59131,
    "reactomeId" : 983438,
    "displayName" : "Cell surface",
    "schemaClass" : "OtherEntity",
    "renderableClass" : "Entity",
    "position" : {
      "x" : 1745,
      "y" : 256
    },
    "minX" : 1707,
    "maxX" : 1783,
    "minY" : 218,
    "maxY" : 268,
    "prop" : {
      "x" : 1707,
      "y" : 245,
      "width" : 76,
      "height" : 23
    },
    "textPosition" : {
      "x" : 1717,
      "y" : 239
    },
    "connectors" : [ {
      "edgeId" : 59129,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1756,
          "y" : 242
        },
        "to" : {
          "x" : 1782,
          "y" : 218
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 59133,
    "reactomeId" : 983438,
    "displayName" : "Cell surface",
    "schemaClass" : "OtherEntity",
    "renderableClass" : "Entity",
    "position" : {
      "x" : 1133,
      "y" : 1162
    },
    "minX" : 1095,
    "maxX" : 1171,
    "minY" : 1151,
    "maxY" : 1207,
    "prop" : {
      "x" : 1095,
      "y" : 1151,
      "width" : 76,
      "height" : 23
    },
    "textPosition" : {
      "x" : 1105,
      "y" : 1145
    },
    "connectors" : [ {
      "edgeId" : 59132,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1136,
          "y" : 1177
        },
        "to" : {
          "x" : 1145,
          "y" : 1207
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 59135,
    "reactomeId" : 10238129,
    "displayName" : "C3 convertases",
    "schemaClass" : "DefinedSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 2785,
      "y" : 283
    },
    "minX" : 2737,
    "maxX" : 2834,
    "minY" : 272,
    "maxY" : 295,
    "prop" : {
      "x" : 2737,
      "y" : 272,
      "width" : 97,
      "height" : 23
    },
    "textPosition" : {
      "x" : 2743,
      "y" : 266
    },
    "connectors" : [ {
      "edgeId" : 59134,
      "type" : "INPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  } ],
  "edges" : [ {
    "id" : 59264,
    "reactomeId" : 10307507,
    "displayName" : "Thrombin, ELANE cleave C5",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 2324,
      "y" : 76
    },
    "minX" : 2216,
    "maxX" : 2414,
    "minY" : 70,
    "maxY" : 82,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 2216,
        "y" : 76
      },
      "to" : {
        "x" : 2324,
        "y" : 76
      }
    }, {
      "from" : {
        "x" : 2324,
        "y" : 76
      },
      "to" : {
        "x" : 2414,
        "y" : 76
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 2318,
        "y" : 70
      },
      "b" : {
        "x" : 2330,
        "y" : 82
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 2324,
        "y" : 76
      }
    },
    "inputs" : [ {
      "id" : 59110
    } ],
    "outputs" : [ {
      "id" : 59265,
      "points" : [ {
        "x" : 2431,
        "y" : 48
      } ]
    }, {
      "id" : 59266,
      "points" : [ {
        "x" : 2455,
        "y" : 76
      } ]
    } ],
    "catalysts" : [ {
      "id" : 59267,
      "points" : [ {
        "x" : 2324,
        "y" : 43
      } ]
    } ]
  }, {
    "id" : 59268,
    "reactomeId" : 10307050,
    "displayName" : "CFHR dimers bind C3b",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 2367,
      "y" : 1107
    },
    "minX" : 2352,
    "maxX" : 2373,
    "minY" : 1075,
    "maxY" : 1137,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 2368,
        "y" : 1075
      },
      "to" : {
        "x" : 2367,
        "y" : 1107
      }
    }, {
      "from" : {
        "x" : 2367,
        "y" : 1107
      },
      "to" : {
        "x" : 2352,
        "y" : 1137
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 2352,
        "y" : 1129
      },
      "b" : {
        "x" : 2352,
        "y" : 1137
      },
      "c" : {
        "x" : 2359,
        "y" : 1133
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 2359,
        "y" : 1133
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 2367,
        "y" : 1107
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 2367,
        "y" : 1107
      }
    },
    "inputs" : [ {
      "id" : 59103,
      "points" : [ {
        "x" : 1297,
        "y" : 1154
      }, {
        "x" : 1486,
        "y" : 1076
      } ]
    }, {
      "id" : 59269,
      "points" : [ {
        "x" : 2390,
        "y" : 1044
      } ]
    } ],
    "outputs" : [ {
      "id" : 59270
    } ]
  }, {
    "id" : 59143,
    "reactomeId" : 10263095,
    "displayName" : "Factor H binds to C3b",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 3263,
      "y" : 1175
    },
    "minX" : 3229,
    "maxX" : 3305,
    "minY" : 1169,
    "maxY" : 1181,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 3229,
        "y" : 1175
      },
      "to" : {
        "x" : 3263,
        "y" : 1175
      }
    }, {
      "from" : {
        "x" : 3263,
        "y" : 1175
      },
      "to" : {
        "x" : 3305,
        "y" : 1175
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 3298,
        "y" : 1179
      },
      "b" : {
        "x" : 3305,
        "y" : 1175
      },
      "c" : {
        "x" : 3298,
        "y" : 1171
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 3298,
        "y" : 1171
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 3263,
        "y" : 1175
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 3263,
        "y" : 1175
      }
    },
    "inputs" : [ {
      "id" : 59144,
      "points" : [ {
        "x" : 3209,
        "y" : 1187
      } ]
    }, {
      "id" : 59145,
      "points" : [ {
        "x" : 3197,
        "y" : 1160
      } ]
    } ],
    "outputs" : [ {
      "id" : 59146
    } ]
  }, {
    "id" : 59271,
    "reactomeId" : 10307538,
    "displayName" : "CR2 binds C3d, C3dg, iC3b",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 4338,
      "y" : 243
    },
    "minX" : 4281,
    "maxX" : 4412,
    "minY" : 237,
    "maxY" : 261,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 4281,
        "y" : 243
      },
      "to" : {
        "x" : 4338,
        "y" : 243
      }
    }, {
      "from" : {
        "x" : 4338,
        "y" : 243
      },
      "to" : {
        "x" : 4412,
        "y" : 261
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 4404,
        "y" : 263
      },
      "b" : {
        "x" : 4412,
        "y" : 261
      },
      "c" : {
        "x" : 4406,
        "y" : 255
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 4406,
        "y" : 255
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 4338,
        "y" : 243
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 4338,
        "y" : 243
      }
    },
    "inputs" : [ {
      "id" : 59272,
      "points" : [ {
        "x" : 4246,
        "y" : 264
      } ]
    }, {
      "id" : 59273,
      "points" : [ {
        "x" : 4307,
        "y" : 259
      } ]
    } ],
    "outputs" : [ {
      "id" : 59274
    } ]
  }, {
    "id" : 59275,
    "reactomeId" : 10307544,
    "displayName" : "CR2:C3d,C3dg,iC3b binds CD19:CD81",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 4496,
      "y" : 321
    },
    "minX" : 4490,
    "maxX" : 4517,
    "minY" : 300,
    "maxY" : 327,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 4496,
        "y" : 300
      },
      "to" : {
        "x" : 4496,
        "y" : 321
      }
    }, {
      "from" : {
        "x" : 4496,
        "y" : 321
      },
      "to" : {
        "x" : 4517,
        "y" : 322
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 4510,
        "y" : 326
      },
      "b" : {
        "x" : 4517,
        "y" : 322
      },
      "c" : {
        "x" : 4510,
        "y" : 318
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 4510,
        "y" : 318
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 4496,
        "y" : 321
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 4496,
        "y" : 321
      }
    },
    "inputs" : [ {
      "id" : 59274,
      "points" : [ {
        "x" : 4473,
        "y" : 290
      } ]
    }, {
      "id" : 59276,
      "points" : [ {
        "x" : 4532,
        "y" : 289
      } ]
    } ],
    "outputs" : [ {
      "id" : 59277
    } ]
  }, {
    "id" : 59147,
    "reactomeId" : 10263417,
    "displayName" : "Factor H binds to membrane-associated C3b",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 2806,
      "y" : 942
    },
    "minX" : 2779,
    "maxX" : 2812,
    "minY" : 824,
    "maxY" : 1093,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 2804,
        "y" : 824
      },
      "to" : {
        "x" : 2806,
        "y" : 942
      }
    }, {
      "from" : {
        "x" : 2806,
        "y" : 942
      },
      "to" : {
        "x" : 2779,
        "y" : 1093
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 2776,
        "y" : 1085
      },
      "b" : {
        "x" : 2779,
        "y" : 1093
      },
      "c" : {
        "x" : 2784,
        "y" : 1087
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 2784,
        "y" : 1087
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 2806,
        "y" : 942
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 2806,
        "y" : 942
      }
    },
    "inputs" : [ {
      "id" : 59148,
      "points" : [ {
        "x" : 2684,
        "y" : 811
      } ]
    }, {
      "id" : 59149,
      "points" : [ {
        "x" : 2750,
        "y" : 784
      } ]
    } ],
    "outputs" : [ {
      "id" : 59150
    } ],
    "activators" : [ {
      "id" : 59151,
      "points" : [ {
        "x" : 3290,
        "y" : 1087
      } ]
    } ]
  }, {
    "id" : 59278,
    "reactomeId" : 10307526,
    "displayName" : "CPN, CPB2 cleave C3a, C5a",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 433,
      "y" : 1341
    },
    "minX" : 401,
    "maxX" : 464,
    "minY" : 1335,
    "maxY" : 1347,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 401,
        "y" : 1341
      },
      "to" : {
        "x" : 433,
        "y" : 1341
      }
    }, {
      "from" : {
        "x" : 433,
        "y" : 1341
      },
      "to" : {
        "x" : 464,
        "y" : 1341
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 457,
        "y" : 1345
      },
      "b" : {
        "x" : 464,
        "y" : 1341
      },
      "c" : {
        "x" : 457,
        "y" : 1337
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 457,
        "y" : 1337
      }
    },
    "reactionShape" : {
      "a" : {
        "x" : 427,
        "y" : 1335
      },
      "b" : {
        "x" : 439,
        "y" : 1347
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 433,
        "y" : 1341
      }
    },
    "inputs" : [ {
      "id" : 59279
    } ],
    "outputs" : [ {
      "id" : 59280
    } ],
    "catalysts" : [ {
      "id" : 59281,
      "points" : [ {
        "x" : 433,
        "y" : 1311
      } ]
    } ]
  }, {
    "id" : 59152,
    "reactomeId" : 10263231,
    "displayName" : "Factor H binds to C3bBb",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 2697,
      "y" : 941
    },
    "minX" : 2691,
    "maxX" : 2717,
    "minY" : 898,
    "maxY" : 984,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 2699,
        "y" : 898
      },
      "to" : {
        "x" : 2697,
        "y" : 941
      }
    }, {
      "from" : {
        "x" : 2697,
        "y" : 941
      },
      "to" : {
        "x" : 2717,
        "y" : 984
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 2710,
        "y" : 979
      },
      "b" : {
        "x" : 2717,
        "y" : 984
      },
      "c" : {
        "x" : 2718,
        "y" : 976
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 2718,
        "y" : 976
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 2697,
        "y" : 941
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 2697,
        "y" : 941
      }
    },
    "inputs" : [ {
      "id" : 59148,
      "points" : [ {
        "x" : 2645,
        "y" : 826
      } ]
    }, {
      "id" : 59153,
      "points" : [ {
        "x" : 2724,
        "y" : 870
      } ]
    } ],
    "outputs" : [ {
      "id" : 59154
    } ],
    "activators" : [ {
      "id" : 59151,
      "points" : [ {
        "x" : 3282,
        "y" : 1087
      } ]
    } ]
  }, {
    "id" : 59282,
    "reactomeId" : 10265144,
    "displayName" : "CD46 binds C3b",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 4644,
      "y" : 425
    },
    "minX" : 4603,
    "maxX" : 4650,
    "minY" : 398,
    "maxY" : 446,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 4643,
        "y" : 398
      },
      "to" : {
        "x" : 4644,
        "y" : 425
      }
    }, {
      "from" : {
        "x" : 4644,
        "y" : 425
      },
      "to" : {
        "x" : 4603,
        "y" : 446
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 4607,
        "y" : 439
      },
      "b" : {
        "x" : 4603,
        "y" : 446
      },
      "c" : {
        "x" : 4611,
        "y" : 446
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 4611,
        "y" : 446
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 4644,
        "y" : 425
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 4644,
        "y" : 425
      }
    },
    "inputs" : [ {
      "id" : 59283,
      "points" : [ {
        "x" : 4591,
        "y" : 412
      } ]
    }, {
      "id" : 59284,
      "points" : [ {
        "x" : 4598,
        "y" : 384
      } ]
    } ],
    "outputs" : [ {
      "id" : 59285
    } ]
  }, {
    "id" : 59155,
    "reactomeId" : 10263283,
    "displayName" : "Factor H displaces Bb",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 2750,
      "y" : 1056
    },
    "minX" : 2734,
    "maxX" : 2766,
    "minY" : 1027,
    "maxY" : 1073,
    "reactionType" : "dissociation",
    "segments" : [ {
      "from" : {
        "x" : 2734,
        "y" : 1027
      },
      "to" : {
        "x" : 2750,
        "y" : 1056
      }
    }, {
      "from" : {
        "x" : 2750,
        "y" : 1056
      },
      "to" : {
        "x" : 2766,
        "y" : 1073
      }
    } ],
    "reactionShape" : {
      "c" : {
        "x" : 2750,
        "y" : 1056
      },
      "r" : 5,
      "r1" : 3,
      "type" : "DOUBLE_CIRCLE",
      "empty" : true,
      "centre" : {
        "x" : 2750,
        "y" : 1056
      }
    },
    "inputs" : [ {
      "id" : 59154
    } ],
    "outputs" : [ {
      "id" : 59136,
      "points" : [ {
        "x" : 3209,
        "y" : 298
      } ]
    }, {
      "id" : 59150,
      "points" : [ {
        "x" : 2771,
        "y" : 1093
      } ]
    } ]
  }, {
    "id" : 59156,
    "reactomeId" : 10263097,
    "displayName" : "Complement factor I complex formation",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 3678,
      "y" : 1363
    },
    "minX" : 3534,
    "maxX" : 3744,
    "minY" : 1357,
    "maxY" : 1369,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 3744,
        "y" : 1363
      },
      "to" : {
        "x" : 3678,
        "y" : 1363
      }
    }, {
      "from" : {
        "x" : 3678,
        "y" : 1363
      },
      "to" : {
        "x" : 3534,
        "y" : 1361
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 3541,
        "y" : 1357
      },
      "b" : {
        "x" : 3534,
        "y" : 1361
      },
      "c" : {
        "x" : 3541,
        "y" : 1365
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 3541,
        "y" : 1365
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 3678,
        "y" : 1363
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 3678,
        "y" : 1363
      }
    },
    "inputs" : [ {
      "id" : 59157,
      "points" : [ {
        "x" : 3794,
        "y" : 1347
      } ]
    }, {
      "id" : 59158,
      "points" : [ {
        "x" : 3786,
        "y" : 1373
      } ]
    } ],
    "outputs" : [ {
      "id" : 59159
    } ]
  }, {
    "id" : 59286,
    "reactomeId" : 10313476,
    "displayName" : "CD46 binds C4b",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 4689,
      "y" : 509
    },
    "minX" : 4611,
    "maxX" : 4695,
    "minY" : 471,
    "maxY" : 537,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 4689,
        "y" : 471
      },
      "to" : {
        "x" : 4689,
        "y" : 509
      }
    }, {
      "from" : {
        "x" : 4689,
        "y" : 509
      },
      "to" : {
        "x" : 4611,
        "y" : 537
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 4616,
        "y" : 531
      },
      "b" : {
        "x" : 4611,
        "y" : 537
      },
      "c" : {
        "x" : 4619,
        "y" : 538
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 4619,
        "y" : 538
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 4689,
        "y" : 509
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 4689,
        "y" : 509
      }
    },
    "inputs" : [ {
      "id" : 59283,
      "points" : [ {
        "x" : 4591,
        "y" : 427
      } ]
    }, {
      "id" : 59287,
      "points" : [ {
        "x" : 4593,
        "y" : 504
      } ]
    } ],
    "outputs" : [ {
      "id" : 59288
    } ]
  }, {
    "id" : 59160,
    "reactomeId" : 10263099,
    "displayName" : "Complement factor I binds to extracellular Factor H:C3b",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 3336,
      "y" : 1251
    },
    "minX" : 3295,
    "maxX" : 3362,
    "minY" : 1245,
    "maxY" : 1257,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 3362,
        "y" : 1251
      },
      "to" : {
        "x" : 3336,
        "y" : 1251
      }
    }, {
      "from" : {
        "x" : 3336,
        "y" : 1251
      },
      "to" : {
        "x" : 3295,
        "y" : 1251
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 3302,
        "y" : 1247
      },
      "b" : {
        "x" : 3295,
        "y" : 1251
      },
      "c" : {
        "x" : 3302,
        "y" : 1255
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 3302,
        "y" : 1255
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 3336,
        "y" : 1251
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 3336,
        "y" : 1251
      }
    },
    "inputs" : [ {
      "id" : 59146,
      "points" : [ {
        "x" : 3341,
        "y" : 1191
      } ]
    }, {
      "id" : 59159,
      "points" : [ {
        "x" : 3502,
        "y" : 1351
      } ]
    } ],
    "outputs" : [ {
      "id" : 59161
    } ]
  }, {
    "id" : 59289,
    "reactomeId" : 10317448,
    "displayName" : "C1-Inh binds and inactivates C1r, C1s",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 1287,
      "y" : 315
    },
    "minX" : 1246,
    "maxX" : 1304,
    "minY" : 288,
    "maxY" : 321,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 1246,
        "y" : 288
      },
      "to" : {
        "x" : 1287,
        "y" : 315
      }
    }, {
      "from" : {
        "x" : 1287,
        "y" : 315
      },
      "to" : {
        "x" : 1304,
        "y" : 300
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 1301,
        "y" : 308
      },
      "b" : {
        "x" : 1304,
        "y" : 300
      },
      "c" : {
        "x" : 1296,
        "y" : 302
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 1296,
        "y" : 302
      }
    },
    "reactionShape" : {
      "a" : {
        "x" : 1281,
        "y" : 309
      },
      "b" : {
        "x" : 1293,
        "y" : 321
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 1287,
        "y" : 315
      }
    },
    "inputs" : [ {
      "id" : 59242
    } ],
    "outputs" : [ {
      "id" : 59244
    } ]
  }, {
    "id" : 59162,
    "reactomeId" : 10263225,
    "displayName" : "Complement factor I binds to membrane-associated Factor H:C3b",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 2856,
      "y" : 1148
    },
    "minX" : 2828,
    "maxX" : 2892,
    "minY" : 1120,
    "maxY" : 1154,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 2828,
        "y" : 1148
      },
      "to" : {
        "x" : 2856,
        "y" : 1148
      }
    }, {
      "from" : {
        "x" : 2856,
        "y" : 1148
      },
      "to" : {
        "x" : 2892,
        "y" : 1120
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 2889,
        "y" : 1127
      },
      "b" : {
        "x" : 2892,
        "y" : 1120
      },
      "c" : {
        "x" : 2884,
        "y" : 1121
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 2884,
        "y" : 1121
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 2856,
        "y" : 1148
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 2856,
        "y" : 1148
      }
    },
    "inputs" : [ {
      "id" : 59150,
      "points" : [ {
        "x" : 2804,
        "y" : 1136
      } ]
    }, {
      "id" : 59159,
      "points" : [ {
        "x" : 3502,
        "y" : 1361
      }, {
        "x" : 2938,
        "y" : 1361
      } ]
    } ],
    "outputs" : [ {
      "id" : 59163
    } ]
  }, {
    "id" : 59290,
    "reactomeId" : 10320350,
    "displayName" : "C5 binds C5 inhibitors",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 2138,
      "y" : 121
    },
    "minX" : 2132,
    "maxX" : 2144,
    "minY" : 95,
    "maxY" : 141,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 2138,
        "y" : 101
      },
      "to" : {
        "x" : 2138,
        "y" : 121
      }
    }, {
      "from" : {
        "x" : 2138,
        "y" : 121
      },
      "to" : {
        "x" : 2138,
        "y" : 141
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 2134,
        "y" : 134
      },
      "b" : {
        "x" : 2138,
        "y" : 141
      },
      "c" : {
        "x" : 2142,
        "y" : 134
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 2142,
        "y" : 134
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 2138,
        "y" : 121
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 2138,
        "y" : 121
      }
    },
    "inputs" : [ {
      "id" : 59110,
      "points" : [ {
        "x" : 2185,
        "y" : 81
      } ]
    }, {
      "id" : 59291,
      "points" : [ {
        "x" : 2091,
        "y" : 84
      } ]
    } ],
    "outputs" : [ {
      "id" : 59292
    } ]
  }, {
    "id" : 59164,
    "reactomeId" : 10263249,
    "displayName" : "Factor I inactivates Factor H-boundC3b",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 2991,
      "y" : 1106
    },
    "minX" : 2967,
    "maxX" : 3010,
    "minY" : 1100,
    "maxY" : 1112,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 2967,
        "y" : 1105
      },
      "to" : {
        "x" : 2991,
        "y" : 1106
      }
    }, {
      "from" : {
        "x" : 2991,
        "y" : 1106
      },
      "to" : {
        "x" : 3010,
        "y" : 1105
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 2985,
        "y" : 1100
      },
      "b" : {
        "x" : 2997,
        "y" : 1112
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 2991,
        "y" : 1106
      }
    },
    "inputs" : [ {
      "id" : 59163
    } ],
    "outputs" : [ {
      "id" : 59165,
      "points" : [ {
        "x" : 3026,
        "y" : 1105
      } ]
    }, {
      "id" : 59166,
      "points" : [ {
        "x" : 3057,
        "y" : 1150
      } ]
    } ],
    "catalysts" : [ {
      "id" : 59163,
      "points" : [ {
        "x" : 2933,
        "y" : 1120
      }, {
        "x" : 2991,
        "y" : 1141
      } ]
    } ]
  }, {
    "id" : 59293,
    "reactomeId" : 10328220,
    "displayName" : "C3 binds C3 inhibitors",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 592,
      "y" : 1464
    },
    "minX" : 586,
    "maxX" : 598,
    "minY" : 1440,
    "maxY" : 1499,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 592,
        "y" : 1440
      },
      "to" : {
        "x" : 592,
        "y" : 1464
      }
    }, {
      "from" : {
        "x" : 592,
        "y" : 1464
      },
      "to" : {
        "x" : 593,
        "y" : 1499
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 589,
        "y" : 1492
      },
      "b" : {
        "x" : 593,
        "y" : 1499
      },
      "c" : {
        "x" : 597,
        "y" : 1492
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 597,
        "y" : 1492
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 592,
        "y" : 1464
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 592,
        "y" : 1464
      }
    },
    "inputs" : [ {
      "id" : 59080,
      "points" : [ {
        "x" : 611,
        "y" : 1273
      } ]
    }, {
      "id" : 59294,
      "points" : [ {
        "x" : 545,
        "y" : 1426
      } ]
    } ],
    "outputs" : [ {
      "id" : 59295
    } ]
  }, {
    "id" : 59167,
    "reactomeId" : 10263263,
    "displayName" : "CR1 binds C3bBb/C4bC2a",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 3608,
      "y" : 239
    },
    "minX" : 3578,
    "maxX" : 3688,
    "minY" : 233,
    "maxY" : 258,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 3688,
        "y" : 238
      },
      "to" : {
        "x" : 3608,
        "y" : 239
      }
    }, {
      "from" : {
        "x" : 3608,
        "y" : 239
      },
      "to" : {
        "x" : 3578,
        "y" : 258
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 3582,
        "y" : 251
      },
      "b" : {
        "x" : 3578,
        "y" : 258
      },
      "c" : {
        "x" : 3586,
        "y" : 258
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 3586,
        "y" : 258
      }
    },
    "reactionShape" : {
      "a" : {
        "x" : 3602,
        "y" : 233
      },
      "b" : {
        "x" : 3614,
        "y" : 245
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 3608,
        "y" : 239
      }
    },
    "inputs" : [ {
      "id" : 59168,
      "points" : [ {
        "x" : 3672,
        "y" : 264
      } ],
      "stoichiometry" : 2
    }, {
      "id" : 59169,
      "points" : [ {
        "x" : 3740,
        "y" : 266
      } ]
    } ],
    "outputs" : [ {
      "id" : 59170
    } ]
  }, {
    "id" : 59296,
    "reactomeId" : 10328224,
    "displayName" : "C5a binds C5a inhibitor",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 2406,
      "y" : 273
    },
    "minX" : 2400,
    "maxX" : 2428,
    "minY" : 248,
    "maxY" : 288,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 2407,
        "y" : 248
      },
      "to" : {
        "x" : 2406,
        "y" : 273
      }
    }, {
      "from" : {
        "x" : 2406,
        "y" : 273
      },
      "to" : {
        "x" : 2428,
        "y" : 288
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 2420,
        "y" : 287
      },
      "b" : {
        "x" : 2428,
        "y" : 288
      },
      "c" : {
        "x" : 2425,
        "y" : 281
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 2425,
        "y" : 281
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 2406,
        "y" : 273
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 2406,
        "y" : 273
      }
    },
    "inputs" : [ {
      "id" : 59111,
      "points" : [ {
        "x" : 2387,
        "y" : 229
      } ]
    }, {
      "id" : 59297,
      "points" : [ {
        "x" : 2431,
        "y" : 233
      } ]
    } ],
    "outputs" : [ {
      "id" : 59298
    } ]
  }, {
    "id" : 59171,
    "reactomeId" : 10263341,
    "displayName" : "Displacement of C2a/Bb by CR1",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 3471,
      "y" : 244
    },
    "minX" : 3412,
    "maxX" : 3515,
    "minY" : 238,
    "maxY" : 258,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 3515,
        "y" : 258
      },
      "to" : {
        "x" : 3471,
        "y" : 244
      }
    }, {
      "from" : {
        "x" : 3471,
        "y" : 244
      },
      "to" : {
        "x" : 3412,
        "y" : 244
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 3465,
        "y" : 238
      },
      "b" : {
        "x" : 3477,
        "y" : 250
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 3471,
        "y" : 244
      }
    },
    "inputs" : [ {
      "id" : 59170
    } ],
    "outputs" : [ {
      "id" : 59172,
      "points" : [ {
        "x" : 3429,
        "y" : 268
      } ]
    }, {
      "id" : 59136,
      "points" : [ {
        "x" : 3266,
        "y" : 273
      } ]
    }, {
      "id" : 59173,
      "points" : [ {
        "x" : 3367,
        "y" : 268
      } ]
    }, {
      "id" : 59174,
      "points" : [ {
        "x" : 3389,
        "y" : 231
      } ]
    } ]
  }, {
    "id" : 59299,
    "reactomeId" : 10328228,
    "displayName" : "C5AR1 binds C5AR1 antagonist",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 2405,
      "y" : 415
    },
    "minX" : 2370,
    "maxX" : 2411,
    "minY" : 379,
    "maxY" : 433,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 2406,
        "y" : 379
      },
      "to" : {
        "x" : 2405,
        "y" : 415
      }
    }, {
      "from" : {
        "x" : 2405,
        "y" : 415
      },
      "to" : {
        "x" : 2370,
        "y" : 433
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 2374,
        "y" : 426
      },
      "b" : {
        "x" : 2370,
        "y" : 433
      },
      "c" : {
        "x" : 2378,
        "y" : 433
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 2378,
        "y" : 433
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 2405,
        "y" : 415
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 2405,
        "y" : 415
      }
    },
    "inputs" : [ {
      "id" : 59259,
      "points" : [ {
        "x" : 2340,
        "y" : 310
      } ]
    }, {
      "id" : 59300,
      "points" : [ {
        "x" : 2443,
        "y" : 364
      } ]
    } ],
    "outputs" : [ {
      "id" : 59301
    } ]
  }, {
    "id" : 59175,
    "reactomeId" : 10263281,
    "displayName" : "Complement factor I binds to MCP, CR1:C4b, C3b",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 3856,
      "y" : 1154
    },
    "minX" : 3818,
    "maxX" : 3889,
    "minY" : 1129,
    "maxY" : 1160,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 3818,
        "y" : 1154
      },
      "to" : {
        "x" : 3856,
        "y" : 1154
      }
    }, {
      "from" : {
        "x" : 3856,
        "y" : 1154
      },
      "to" : {
        "x" : 3889,
        "y" : 1129
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 3886,
        "y" : 1136
      },
      "b" : {
        "x" : 3889,
        "y" : 1129
      },
      "c" : {
        "x" : 3881,
        "y" : 1130
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 3881,
        "y" : 1130
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 3856,
        "y" : 1154
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 3856,
        "y" : 1154
      }
    },
    "inputs" : [ {
      "id" : 59176,
      "points" : [ {
        "x" : 3782,
        "y" : 1132
      } ]
    }, {
      "id" : 59159,
      "points" : [ {
        "x" : 3534,
        "y" : 1352
      } ]
    } ],
    "outputs" : [ {
      "id" : 59177
    } ]
  }, {
    "id" : 59178,
    "reactomeId" : 10263300,
    "displayName" : "Factor I inactivates MCP/CR1-bound C4b/C3b",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 4002,
      "y" : 1141
    },
    "minX" : 3960,
    "maxX" : 4049,
    "minY" : 1129,
    "maxY" : 1151,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 3960,
        "y" : 1129
      },
      "to" : {
        "x" : 4002,
        "y" : 1141
      }
    }, {
      "from" : {
        "x" : 4002,
        "y" : 1141
      },
      "to" : {
        "x" : 4049,
        "y" : 1151
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 3996,
        "y" : 1135
      },
      "b" : {
        "x" : 4008,
        "y" : 1147
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 4002,
        "y" : 1141
      }
    },
    "inputs" : [ {
      "id" : 59177
    } ],
    "outputs" : [ {
      "id" : 59179,
      "points" : [ {
        "x" : 4055,
        "y" : 1122
      } ],
      "stoichiometry" : 2
    }, {
      "id" : 59159,
      "points" : [ {
        "x" : 3534,
        "y" : 1355
      } ]
    }, {
      "id" : 59180,
      "points" : [ {
        "x" : 4100,
        "y" : 1166
      } ],
      "stoichiometry" : 2
    }, {
      "id" : 59181,
      "points" : [ {
        "x" : 4139,
        "y" : 1122
      } ],
      "stoichiometry" : 2
    } ],
    "catalysts" : [ {
      "id" : 59177,
      "points" : [ {
        "x" : 3980,
        "y" : 1104
      }, {
        "x" : 4003,
        "y" : 1104
      } ]
    } ]
  }, {
    "id" : 59182,
    "reactomeId" : 10263393,
    "displayName" : "CD55 (DAF) binds C3bBb, C4bC2a",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 3910,
      "y" : 231
    },
    "minX" : 3876,
    "maxX" : 3943,
    "minY" : 225,
    "maxY" : 260,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 3876,
        "y" : 231
      },
      "to" : {
        "x" : 3910,
        "y" : 231
      }
    }, {
      "from" : {
        "x" : 3910,
        "y" : 231
      },
      "to" : {
        "x" : 3943,
        "y" : 260
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 3935,
        "y" : 258
      },
      "b" : {
        "x" : 3943,
        "y" : 260
      },
      "c" : {
        "x" : 3940,
        "y" : 252
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 3940,
        "y" : 252
      }
    },
    "reactionShape" : {
      "a" : {
        "x" : 3904,
        "y" : 225
      },
      "b" : {
        "x" : 3916,
        "y" : 237
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 3910,
        "y" : 231
      }
    },
    "inputs" : [ {
      "id" : 59169,
      "points" : [ {
        "x" : 3784,
        "y" : 266
      } ]
    }, {
      "id" : 59183,
      "points" : [ {
        "x" : 3857,
        "y" : 265
      } ],
      "stoichiometry" : 2
    } ],
    "outputs" : [ {
      "id" : 59184
    } ]
  }, {
    "id" : 59185,
    "reactomeId" : 10263314,
    "displayName" : "CD55 (DAF) promotes C3bBb/C4bC2a dissociation",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 4006,
      "y" : 229
    },
    "minX" : 3976,
    "maxX" : 4071,
    "minY" : 223,
    "maxY" : 260,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 3976,
        "y" : 260
      },
      "to" : {
        "x" : 4006,
        "y" : 229
      }
    }, {
      "from" : {
        "x" : 4006,
        "y" : 229
      },
      "to" : {
        "x" : 4071,
        "y" : 230
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 4000,
        "y" : 223
      },
      "b" : {
        "x" : 4012,
        "y" : 235
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 4006,
        "y" : 229
      }
    },
    "inputs" : [ {
      "id" : 59184
    } ],
    "outputs" : [ {
      "id" : 59186,
      "points" : [ {
        "x" : 4141,
        "y" : 265
      } ]
    }, {
      "id" : 59136,
      "points" : [ {
        "x" : 3224,
        "y" : 269
      }, {
        "x" : 3294,
        "y" : 172
      }, {
        "x" : 4036,
        "y" : 165
      } ]
    }, {
      "id" : 59187,
      "points" : [ {
        "x" : 4076,
        "y" : 266
      } ]
    }, {
      "id" : 59188,
      "points" : [ {
        "x" : 4098,
        "y" : 214
      } ]
    } ]
  }, {
    "id" : 59189,
    "reactomeId" : 10263339,
    "displayName" : "C4b-binding protein binds C4b",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 4643,
      "y" : 1043
    },
    "minX" : 4356,
    "maxX" : 4649,
    "minY" : 866,
    "maxY" : 1095,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 4642,
        "y" : 866
      },
      "to" : {
        "x" : 4643,
        "y" : 1043
      }
    }, {
      "from" : {
        "x" : 4643,
        "y" : 1043
      },
      "to" : {
        "x" : 4356,
        "y" : 1095
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 4362,
        "y" : 1090
      },
      "b" : {
        "x" : 4356,
        "y" : 1095
      },
      "c" : {
        "x" : 4364,
        "y" : 1098
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 4364,
        "y" : 1098
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 4643,
        "y" : 1043
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 4643,
        "y" : 1043
      }
    },
    "inputs" : [ {
      "id" : 59190,
      "points" : [ {
        "x" : 4570,
        "y" : 781
      } ]
    }, {
      "id" : 59191,
      "points" : [ {
        "x" : 4666,
        "y" : 823
      } ],
      "stoichiometry" : 7
    } ],
    "outputs" : [ {
      "id" : 59192
    } ]
  }, {
    "id" : 59193,
    "reactomeId" : 10263407,
    "displayName" : "Complement factor I binds C4BP",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 4503,
      "y" : 1155
    },
    "minX" : 4456,
    "maxX" : 4535,
    "minY" : 1119,
    "maxY" : 1161,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 4456,
        "y" : 1157
      },
      "to" : {
        "x" : 4503,
        "y" : 1155
      }
    }, {
      "from" : {
        "x" : 4503,
        "y" : 1155
      },
      "to" : {
        "x" : 4535,
        "y" : 1119
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 4533,
        "y" : 1127
      },
      "b" : {
        "x" : 4535,
        "y" : 1119
      },
      "c" : {
        "x" : 4527,
        "y" : 1122
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 4527,
        "y" : 1122
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 4503,
        "y" : 1155
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 4503,
        "y" : 1155
      }
    },
    "inputs" : [ {
      "id" : 59192,
      "points" : [ {
        "x" : 4356,
        "y" : 1125
      } ]
    }, {
      "id" : 59159,
      "points" : [ {
        "x" : 3534,
        "y" : 1358
      } ]
    } ],
    "outputs" : [ {
      "id" : 59194
    } ]
  }, {
    "id" : 59195,
    "reactomeId" : 10263401,
    "displayName" : "Complement factor I inactivates C4BP-bound C4b",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 4550,
      "y" : 1156
    },
    "minX" : 4544,
    "maxX" : 4556,
    "minY" : 1119,
    "maxY" : 1188,
    "reactionType" : "dissociation",
    "segments" : [ {
      "from" : {
        "x" : 4550,
        "y" : 1119
      },
      "to" : {
        "x" : 4550,
        "y" : 1156
      }
    }, {
      "from" : {
        "x" : 4550,
        "y" : 1156
      },
      "to" : {
        "x" : 4552,
        "y" : 1188
      }
    } ],
    "reactionShape" : {
      "c" : {
        "x" : 4550,
        "y" : 1156
      },
      "r" : 5,
      "r1" : 3,
      "type" : "DOUBLE_CIRCLE",
      "empty" : true,
      "centre" : {
        "x" : 4550,
        "y" : 1156
      }
    },
    "inputs" : [ {
      "id" : 59194
    } ],
    "outputs" : [ {
      "id" : 59196,
      "points" : [ {
        "x" : 4515,
        "y" : 1245
      } ],
      "stoichiometry" : 7
    }, {
      "id" : 59197,
      "points" : [ {
        "x" : 4588,
        "y" : 1244
      } ],
      "stoichiometry" : 7
    }, {
      "id" : 59190,
      "points" : [ {
        "x" : 4628,
        "y" : 765
      }, {
        "x" : 4825,
        "y" : 763
      }, {
        "x" : 4823,
        "y" : 1099
      } ]
    }, {
      "id" : 59159,
      "points" : [ {
        "x" : 3534,
        "y" : 1358
      } ]
    } ]
  }, {
    "id" : 59069,
    "reactomeId" : 10239526,
    "displayName" : "Activation of C1r",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 782,
      "y" : 255
    },
    "minX" : 733,
    "maxX" : 813,
    "minY" : 249,
    "maxY" : 261,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 733,
        "y" : 255
      },
      "to" : {
        "x" : 782,
        "y" : 255
      }
    }, {
      "from" : {
        "x" : 782,
        "y" : 255
      },
      "to" : {
        "x" : 813,
        "y" : 255
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 806,
        "y" : 259
      },
      "b" : {
        "x" : 813,
        "y" : 255
      },
      "c" : {
        "x" : 806,
        "y" : 251
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 806,
        "y" : 251
      }
    },
    "reactionShape" : {
      "a" : {
        "x" : 776,
        "y" : 249
      },
      "b" : {
        "x" : 788,
        "y" : 261
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 782,
        "y" : 255
      }
    },
    "inputs" : [ {
      "id" : 59070
    } ],
    "outputs" : [ {
      "id" : 59071
    } ],
    "catalysts" : [ {
      "id" : 59070,
      "points" : [ {
        "x" : 733,
        "y" : 271
      }, {
        "x" : 782,
        "y" : 287
      } ]
    } ],
    "activators" : [ {
      "id" : 59072,
      "points" : [ {
        "x" : 781,
        "y" : 210
      } ]
    } ]
  }, {
    "id" : 59198,
    "reactomeId" : 10263405,
    "displayName" : "C4b binding protein binds C4bC2a",
    "schemaClass" : "BlackBoxEvent",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 4617,
      "y" : 892
    },
    "minX" : 4568,
    "maxX" : 4623,
    "minY" : 856,
    "maxY" : 919,
    "reactionType" : "omitted",
    "segments" : [ {
      "from" : {
        "x" : 4617,
        "y" : 856
      },
      "to" : {
        "x" : 4617,
        "y" : 892
      }
    }, {
      "from" : {
        "x" : 4617,
        "y" : 892
      },
      "to" : {
        "x" : 4568,
        "y" : 919
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 4572,
        "y" : 912
      },
      "b" : {
        "x" : 4568,
        "y" : 919
      },
      "c" : {
        "x" : 4576,
        "y" : 919
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 4576,
        "y" : 919
      }
    },
    "reactionShape" : {
      "a" : {
        "x" : 4611,
        "y" : 886
      },
      "b" : {
        "x" : 4623,
        "y" : 898
      },
      "s" : "\\\\",
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 4617,
        "y" : 892
      }
    },
    "inputs" : [ {
      "id" : 59190,
      "points" : [ {
        "x" : 4568,
        "y" : 781
      } ]
    }, {
      "id" : 59199,
      "points" : [ {
        "x" : 4584,
        "y" : 858
      } ],
      "stoichiometry" : 7
    } ],
    "outputs" : [ {
      "id" : 59200
    } ]
  }, {
    "id" : 59073,
    "reactomeId" : 10239542,
    "displayName" : "Activation of C1s",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 979,
      "y" : 256
    },
    "minX" : 950,
    "maxX" : 1010,
    "minY" : 250,
    "maxY" : 262,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 950,
        "y" : 256
      },
      "to" : {
        "x" : 979,
        "y" : 256
      }
    }, {
      "from" : {
        "x" : 979,
        "y" : 256
      },
      "to" : {
        "x" : 1010,
        "y" : 256
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 1003,
        "y" : 260
      },
      "b" : {
        "x" : 1010,
        "y" : 256
      },
      "c" : {
        "x" : 1003,
        "y" : 252
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 1003,
        "y" : 252
      }
    },
    "reactionShape" : {
      "a" : {
        "x" : 973,
        "y" : 250
      },
      "b" : {
        "x" : 985,
        "y" : 262
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 979,
        "y" : 256
      }
    },
    "inputs" : [ {
      "id" : 59071
    } ],
    "outputs" : [ {
      "id" : 59074
    } ],
    "catalysts" : [ {
      "id" : 59071,
      "points" : [ {
        "x" : 931,
        "y" : 278
      }, {
        "x" : 979,
        "y" : 292
      } ]
    } ]
  }, {
    "id" : 59201,
    "reactomeId" : 10263413,
    "displayName" : "C4b binding protein displaces C2a",
    "schemaClass" : "BlackBoxEvent",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 4536,
      "y" : 988
    },
    "minX" : 4530,
    "maxX" : 4542,
    "minY" : 962,
    "maxY" : 1021,
    "reactionType" : "omitted",
    "segments" : [ {
      "from" : {
        "x" : 4537,
        "y" : 962
      },
      "to" : {
        "x" : 4536,
        "y" : 988
      }
    }, {
      "from" : {
        "x" : 4536,
        "y" : 988
      },
      "to" : {
        "x" : 4536,
        "y" : 1021
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 4530,
        "y" : 982
      },
      "b" : {
        "x" : 4542,
        "y" : 994
      },
      "s" : "\\\\",
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 4536,
        "y" : 988
      }
    },
    "inputs" : [ {
      "id" : 59200
    } ],
    "outputs" : [ {
      "id" : 59192,
      "points" : [ {
        "x" : 4343,
        "y" : 1086
      } ]
    }, {
      "id" : 59202,
      "points" : [ {
        "x" : 4592,
        "y" : 1022
      } ],
      "stoichiometry" : 7
    } ]
  }, {
    "id" : 59075,
    "reactomeId" : 10238085,
    "displayName" : "Formation of Classical C3 convertase (C4b:C2a complex)",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 1938,
      "y" : 218
    },
    "minX" : 1893,
    "maxX" : 1958,
    "minY" : 212,
    "maxY" : 242,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 1893,
        "y" : 218
      },
      "to" : {
        "x" : 1938,
        "y" : 218
      }
    }, {
      "from" : {
        "x" : 1938,
        "y" : 218
      },
      "to" : {
        "x" : 1958,
        "y" : 242
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 1950,
        "y" : 239
      },
      "b" : {
        "x" : 1958,
        "y" : 242
      },
      "c" : {
        "x" : 1957,
        "y" : 234
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 1957,
        "y" : 234
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 1938,
        "y" : 218
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 1938,
        "y" : 218
      }
    },
    "inputs" : [ {
      "id" : 59076,
      "points" : [ {
        "x" : 1869,
        "y" : 242
      } ]
    }, {
      "id" : 59077,
      "points" : [ {
        "x" : 1823,
        "y" : 52
      } ]
    } ],
    "outputs" : [ {
      "id" : 59078
    } ]
  }, {
    "id" : 59203,
    "reactomeId" : 10265146,
    "displayName" : "Factor H binds host cell surface markers",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 3283,
      "y" : 1134
    },
    "minX" : 3231,
    "maxX" : 3312,
    "minY" : 1116,
    "maxY" : 1140,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 3231,
        "y" : 1135
      },
      "to" : {
        "x" : 3283,
        "y" : 1134
      }
    }, {
      "from" : {
        "x" : 3283,
        "y" : 1134
      },
      "to" : {
        "x" : 3312,
        "y" : 1116
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 3308,
        "y" : 1123
      },
      "b" : {
        "x" : 3312,
        "y" : 1116
      },
      "c" : {
        "x" : 3304,
        "y" : 1116
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 3304,
        "y" : 1116
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 3283,
        "y" : 1134
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 3283,
        "y" : 1134
      }
    },
    "inputs" : [ {
      "id" : 59145,
      "points" : [ {
        "x" : 3197,
        "y" : 1148
      } ]
    }, {
      "id" : 59204,
      "points" : [ {
        "x" : 3218,
        "y" : 1118
      } ]
    } ],
    "outputs" : [ {
      "id" : 59151
    } ]
  }, {
    "id" : 59205,
    "reactomeId" : 10263411,
    "displayName" : "C4b binding protein binds Protein S",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 4601,
      "y" : 678
    },
    "minX" : 4573,
    "maxX" : 4607,
    "minY" : 653,
    "maxY" : 715,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 4602,
        "y" : 715
      },
      "to" : {
        "x" : 4601,
        "y" : 678
      }
    }, {
      "from" : {
        "x" : 4601,
        "y" : 678
      },
      "to" : {
        "x" : 4573,
        "y" : 653
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 4581,
        "y" : 655
      },
      "b" : {
        "x" : 4573,
        "y" : 653
      },
      "c" : {
        "x" : 4576,
        "y" : 661
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 4576,
        "y" : 661
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 4601,
        "y" : 678
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 4601,
        "y" : 678
      }
    },
    "inputs" : [ {
      "id" : 59190,
      "points" : [ {
        "x" : 4570,
        "y" : 752
      } ]
    }, {
      "id" : 59206,
      "points" : [ {
        "x" : 4637,
        "y" : 712
      } ]
    } ],
    "outputs" : [ {
      "id" : 59207
    } ]
  }, {
    "id" : 59079,
    "reactomeId" : 10239624,
    "displayName" : "Spontaneous hydrolysis of C3 thioester",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 906,
      "y" : 1381
    },
    "minX" : 854,
    "maxX" : 1247,
    "minY" : 1375,
    "maxY" : 1387,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 854,
        "y" : 1381
      },
      "to" : {
        "x" : 906,
        "y" : 1381
      }
    }, {
      "from" : {
        "x" : 906,
        "y" : 1381
      },
      "to" : {
        "x" : 1247,
        "y" : 1381
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 1240,
        "y" : 1385
      },
      "b" : {
        "x" : 1247,
        "y" : 1381
      },
      "c" : {
        "x" : 1240,
        "y" : 1377
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 1240,
        "y" : 1377
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 906,
        "y" : 1381
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 906,
        "y" : 1381
      }
    },
    "inputs" : [ {
      "id" : 59080,
      "points" : [ {
        "x" : 635,
        "y" : 1273
      } ]
    }, {
      "id" : 59081,
      "points" : [ {
        "x" : 821,
        "y" : 1394
      } ]
    } ],
    "outputs" : [ {
      "id" : 59082
    } ]
  }, {
    "id" : 59208,
    "reactomeId" : 10280980,
    "displayName" : "Ficolin-1 binds to molecular patterns on the target cell surface",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 206,
      "y" : 806
    },
    "minX" : 200,
    "maxX" : 232,
    "minY" : 786,
    "maxY" : 814,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 206,
        "y" : 786
      },
      "to" : {
        "x" : 206,
        "y" : 806
      }
    }, {
      "from" : {
        "x" : 206,
        "y" : 806
      },
      "to" : {
        "x" : 232,
        "y" : 814
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 224,
        "y" : 816
      },
      "b" : {
        "x" : 232,
        "y" : 814
      },
      "c" : {
        "x" : 227,
        "y" : 808
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 227,
        "y" : 808
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 206,
        "y" : 806
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 206,
        "y" : 806
      }
    },
    "inputs" : [ {
      "id" : 59209,
      "points" : [ {
        "x" : 173,
        "y" : 780
      } ]
    }, {
      "id" : 59210,
      "points" : [ {
        "x" : 239,
        "y" : 778
      } ]
    }, {
      "id" : 59211,
      "points" : [ {
        "x" : 207,
        "y" : 750
      } ],
      "stoichiometry" : 4
    } ],
    "outputs" : [ {
      "id" : 59212
    } ]
  }, {
    "id" : 59083,
    "reactomeId" : 10239630,
    "displayName" : "Factor B binds to C3(H2O)",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 1370,
      "y" : 1294
    },
    "minX" : 1337,
    "maxX" : 1412,
    "minY" : 1288,
    "maxY" : 1300,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 1337,
        "y" : 1294
      },
      "to" : {
        "x" : 1370,
        "y" : 1294
      }
    }, {
      "from" : {
        "x" : 1370,
        "y" : 1294
      },
      "to" : {
        "x" : 1412,
        "y" : 1294
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 1405,
        "y" : 1298
      },
      "b" : {
        "x" : 1412,
        "y" : 1294
      },
      "c" : {
        "x" : 1405,
        "y" : 1290
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 1405,
        "y" : 1290
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 1370,
        "y" : 1294
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 1370,
        "y" : 1294
      }
    },
    "inputs" : [ {
      "id" : 59082,
      "points" : [ {
        "x" : 1286,
        "y" : 1367
      } ]
    }, {
      "id" : 59084,
      "points" : [ {
        "x" : 1281,
        "y" : 1239
      } ]
    } ],
    "outputs" : [ {
      "id" : 59085
    } ]
  }, {
    "id" : 59213,
    "reactomeId" : 10280968,
    "displayName" : "Ficolin-2 binds to molecular patterns on the target cell surface",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 202,
      "y" : 958
    },
    "minX" : 196,
    "maxX" : 229,
    "minY" : 939,
    "maxY" : 964,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 203,
        "y" : 939
      },
      "to" : {
        "x" : 202,
        "y" : 958
      }
    }, {
      "from" : {
        "x" : 202,
        "y" : 958
      },
      "to" : {
        "x" : 229,
        "y" : 961
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 222,
        "y" : 964
      },
      "b" : {
        "x" : 229,
        "y" : 961
      },
      "c" : {
        "x" : 223,
        "y" : 956
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 223,
        "y" : 956
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 202,
        "y" : 958
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 202,
        "y" : 958
      }
    },
    "inputs" : [ {
      "id" : 59214,
      "points" : [ {
        "x" : 255,
        "y" : 929
      } ]
    }, {
      "id" : 59215,
      "points" : [ {
        "x" : 172,
        "y" : 932
      } ]
    }, {
      "id" : 59216,
      "points" : [ {
        "x" : 203,
        "y" : 909
      } ],
      "stoichiometry" : 4
    } ],
    "outputs" : [ {
      "id" : 59217
    } ]
  }, {
    "id" : 59086,
    "reactomeId" : 10239639,
    "displayName" : "Factor D cleaves C3(H2O)-bound Factor B",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 1568,
      "y" : 1294
    },
    "minX" : 1502,
    "maxX" : 1624,
    "minY" : 1288,
    "maxY" : 1300,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 1502,
        "y" : 1294
      },
      "to" : {
        "x" : 1568,
        "y" : 1294
      }
    }, {
      "from" : {
        "x" : 1568,
        "y" : 1294
      },
      "to" : {
        "x" : 1624,
        "y" : 1295
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 1562,
        "y" : 1288
      },
      "b" : {
        "x" : 1574,
        "y" : 1300
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 1568,
        "y" : 1294
      }
    },
    "inputs" : [ {
      "id" : 59085
    } ],
    "outputs" : [ {
      "id" : 59087,
      "points" : [ {
        "x" : 1684,
        "y" : 1269
      } ]
    }, {
      "id" : 59088,
      "points" : [ {
        "x" : 1677,
        "y" : 1314
      } ]
    } ],
    "catalysts" : [ {
      "id" : 59089,
      "points" : [ {
        "x" : 1569,
        "y" : 1255
      } ]
    } ]
  }, {
    "id" : 59090,
    "reactomeId" : 10239641,
    "displayName" : "Properdin stabilizes C3b:Bb bound to cell surfaces",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 1872,
      "y" : 1178
    },
    "minX" : 1808,
    "maxX" : 1954,
    "minY" : 1167,
    "maxY" : 1184,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 1808,
        "y" : 1178
      },
      "to" : {
        "x" : 1872,
        "y" : 1178
      }
    }, {
      "from" : {
        "x" : 1872,
        "y" : 1178
      },
      "to" : {
        "x" : 1954,
        "y" : 1167
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 1948,
        "y" : 1172
      },
      "b" : {
        "x" : 1954,
        "y" : 1167
      },
      "c" : {
        "x" : 1947,
        "y" : 1164
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 1947,
        "y" : 1164
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 1872,
        "y" : 1178
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 1872,
        "y" : 1178
      }
    },
    "inputs" : [ {
      "id" : 59091,
      "points" : [ {
        "x" : 1769,
        "y" : 1172
      } ]
    }, {
      "id" : 59092,
      "points" : [ {
        "x" : 1799,
        "y" : 1196
      } ]
    } ],
    "outputs" : [ {
      "id" : 59093
    } ]
  }, {
    "id" : 59218,
    "reactomeId" : 10263093,
    "displayName" : "Factor I inactivates plasma Factor H-bound C3b",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 3158,
      "y" : 1249
    },
    "minX" : 3131,
    "maxX" : 3208,
    "minY" : 1243,
    "maxY" : 1255,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 3208,
        "y" : 1250
      },
      "to" : {
        "x" : 3158,
        "y" : 1249
      }
    }, {
      "from" : {
        "x" : 3158,
        "y" : 1249
      },
      "to" : {
        "x" : 3131,
        "y" : 1249
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 3152,
        "y" : 1243
      },
      "b" : {
        "x" : 3164,
        "y" : 1255
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 3158,
        "y" : 1249
      }
    },
    "inputs" : [ {
      "id" : 59161
    } ],
    "outputs" : [ {
      "id" : 59166,
      "points" : [ {
        "x" : 3077,
        "y" : 1179
      } ]
    }, {
      "id" : 59159,
      "points" : [ {
        "x" : 3502,
        "y" : 1359
      }, {
        "x" : 3141,
        "y" : 1324
      } ]
    }, {
      "id" : 59145,
      "points" : [ {
        "x" : 3172,
        "y" : 1169
      } ]
    }, {
      "id" : 59219,
      "points" : [ {
        "x" : 3094,
        "y" : 1272
      } ]
    } ],
    "catalysts" : [ {
      "id" : 59161,
      "points" : [ {
        "x" : 3221,
        "y" : 1266
      }, {
        "x" : 3162,
        "y" : 1286
      } ]
    } ]
  }, {
    "id" : 59220,
    "reactomeId" : 10282417,
    "displayName" : "Factor I cleaves iC3b",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 3525,
      "y" : 1110
    },
    "minX" : 3499,
    "maxX" : 3545,
    "minY" : 1104,
    "maxY" : 1116,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 3499,
        "y" : 1109
      },
      "to" : {
        "x" : 3525,
        "y" : 1110
      }
    }, {
      "from" : {
        "x" : 3525,
        "y" : 1110
      },
      "to" : {
        "x" : 3545,
        "y" : 1110
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 3519,
        "y" : 1104
      },
      "b" : {
        "x" : 3531,
        "y" : 1116
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 3525,
        "y" : 1110
      }
    },
    "inputs" : [ {
      "id" : 59221
    } ],
    "outputs" : [ {
      "id" : 59168,
      "points" : [ {
        "x" : 3664,
        "y" : 293
      } ]
    }, {
      "id" : 59222,
      "points" : [ {
        "x" : 3567,
        "y" : 1107
      } ]
    }, {
      "id" : 59223,
      "points" : [ {
        "x" : 3554,
        "y" : 1137
      } ]
    } ],
    "catalysts" : [ {
      "id" : 59159,
      "points" : [ {
        "x" : 3518,
        "y" : 1347
      } ]
    } ]
  }, {
    "id" : 59094,
    "reactomeId" : 10240013,
    "displayName" : "Formation of alternative pathway C5 convertase",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 2129,
      "y" : 1189
    },
    "minX" : 2094,
    "maxX" : 2163,
    "minY" : 1183,
    "maxY" : 1195,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 2094,
        "y" : 1189
      },
      "to" : {
        "x" : 2129,
        "y" : 1189
      }
    }, {
      "from" : {
        "x" : 2129,
        "y" : 1189
      },
      "to" : {
        "x" : 2163,
        "y" : 1189
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 2123,
        "y" : 1183
      },
      "b" : {
        "x" : 2135,
        "y" : 1195
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 2129,
        "y" : 1189
      }
    },
    "inputs" : [ {
      "id" : 59093,
      "points" : [ {
        "x" : 2067,
        "y" : 1182
      } ]
    }, {
      "id" : 59080,
      "points" : [ {
        "x" : 617,
        "y" : 1273
      }, {
        "x" : 693,
        "y" : 1446
      }, {
        "x" : 2073,
        "y" : 1440
      } ]
    } ],
    "outputs" : [ {
      "id" : 59095,
      "points" : [ {
        "x" : 2188,
        "y" : 1181
      } ]
    }, {
      "id" : 59096,
      "points" : [ {
        "x" : 2191,
        "y" : 1212
      } ]
    } ],
    "catalysts" : [ {
      "id" : 59093,
      "points" : [ {
        "x" : 2087,
        "y" : 1157
      }, {
        "x" : 2127,
        "y" : 1156
      } ]
    } ]
  }, {
    "id" : 59224,
    "reactomeId" : 10280054,
    "displayName" : "CD59 inhibits MAC formation",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 2697,
      "y" : 702
    },
    "minX" : 2691,
    "maxX" : 2722,
    "minY" : 657,
    "maxY" : 717,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 2692,
        "y" : 657
      },
      "to" : {
        "x" : 2697,
        "y" : 702
      }
    }, {
      "from" : {
        "x" : 2697,
        "y" : 702
      },
      "to" : {
        "x" : 2722,
        "y" : 717
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 2714,
        "y" : 717
      },
      "b" : {
        "x" : 2722,
        "y" : 717
      },
      "c" : {
        "x" : 2718,
        "y" : 710
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 2718,
        "y" : 710
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 2697,
        "y" : 702
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 2697,
        "y" : 702
      }
    },
    "inputs" : [ {
      "id" : 59225,
      "points" : [ {
        "x" : 2724,
        "y" : 643
      } ]
    }, {
      "id" : 59127,
      "points" : [ {
        "x" : 2575,
        "y" : 714
      } ]
    }, {
      "id" : 59226,
      "points" : [ {
        "x" : 2731,
        "y" : 608
      } ]
    } ],
    "outputs" : [ {
      "id" : 59227
    } ]
  }, {
    "id" : 59097,
    "reactomeId" : 10238132,
    "displayName" : "Cleavage of C3 by C3 convertases",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 744,
      "y" : 1238
    },
    "minX" : 682,
    "maxX" : 785,
    "minY" : 1232,
    "maxY" : 1248,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 682,
        "y" : 1248
      },
      "to" : {
        "x" : 744,
        "y" : 1238
      }
    }, {
      "from" : {
        "x" : 744,
        "y" : 1238
      },
      "to" : {
        "x" : 785,
        "y" : 1238
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 738,
        "y" : 1232
      },
      "b" : {
        "x" : 750,
        "y" : 1244
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 744,
        "y" : 1238
      }
    },
    "inputs" : [ {
      "id" : 59080
    } ],
    "outputs" : [ {
      "id" : 59098,
      "points" : [ {
        "x" : 877,
        "y" : 1223
      } ]
    }, {
      "id" : 59099,
      "points" : [ {
        "x" : 871,
        "y" : 1270
      } ]
    } ],
    "catalysts" : [ {
      "id" : 59100,
      "points" : [ {
        "x" : 745,
        "y" : 1178
      }, {
        "x" : 743,
        "y" : 1214
      } ]
    } ]
  }, {
    "id" : 59228,
    "reactomeId" : 10280048,
    "displayName" : "Formation of soluble VTN:C5b-C9",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 2426,
      "y" : 589
    },
    "minX" : 2420,
    "maxX" : 2432,
    "minY" : 568,
    "maxY" : 613,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 2427,
        "y" : 568
      },
      "to" : {
        "x" : 2426,
        "y" : 589
      }
    }, {
      "from" : {
        "x" : 2426,
        "y" : 589
      },
      "to" : {
        "x" : 2426,
        "y" : 613
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 2422,
        "y" : 606
      },
      "b" : {
        "x" : 2426,
        "y" : 613
      },
      "c" : {
        "x" : 2430,
        "y" : 606
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 2430,
        "y" : 606
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 2426,
        "y" : 589
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 2426,
        "y" : 589
      }
    },
    "inputs" : [ {
      "id" : 59124,
      "points" : [ {
        "x" : 2400,
        "y" : 543
      } ]
    }, {
      "id" : 59229,
      "points" : [ {
        "x" : 2550,
        "y" : 466
      } ]
    }, {
      "id" : 59230,
      "points" : [ {
        "x" : 2440,
        "y" : 567
      } ]
    } ],
    "outputs" : [ {
      "id" : 59231
    } ]
  }, {
    "id" : 59101,
    "reactomeId" : 10241013,
    "displayName" : "C3(H2O):Factor Bb cleaves C3 to C3b and C3a",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 743,
      "y" : 1267
    },
    "minX" : 682,
    "maxX" : 790,
    "minY" : 1261,
    "maxY" : 1273,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 682,
        "y" : 1262
      },
      "to" : {
        "x" : 743,
        "y" : 1267
      }
    }, {
      "from" : {
        "x" : 743,
        "y" : 1267
      },
      "to" : {
        "x" : 790,
        "y" : 1267
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 737,
        "y" : 1261
      },
      "b" : {
        "x" : 749,
        "y" : 1273
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 743,
        "y" : 1267
      }
    },
    "inputs" : [ {
      "id" : 59080
    } ],
    "outputs" : [ {
      "id" : 59098,
      "points" : [ {
        "x" : 877,
        "y" : 1227
      } ]
    }, {
      "id" : 59099,
      "points" : [ {
        "x" : 871,
        "y" : 1275
      } ]
    } ],
    "catalysts" : [ {
      "id" : 59088,
      "points" : [ {
        "x" : 1664,
        "y" : 1327
      }, {
        "x" : 745,
        "y" : 1310
      } ]
    } ]
  }, {
    "id" : 59102,
    "reactomeId" : 10241010,
    "displayName" : "Factor B binds to surface-associated C3b",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 1379,
      "y" : 1196
    },
    "minX" : 1345,
    "maxX" : 1414,
    "minY" : 1182,
    "maxY" : 1202,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 1345,
        "y" : 1196
      },
      "to" : {
        "x" : 1379,
        "y" : 1196
      }
    }, {
      "from" : {
        "x" : 1379,
        "y" : 1196
      },
      "to" : {
        "x" : 1414,
        "y" : 1182
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 1409,
        "y" : 1188
      },
      "b" : {
        "x" : 1414,
        "y" : 1182
      },
      "c" : {
        "x" : 1406,
        "y" : 1181
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 1406,
        "y" : 1181
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 1379,
        "y" : 1196
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 1379,
        "y" : 1196
      }
    },
    "inputs" : [ {
      "id" : 59103,
      "points" : [ {
        "x" : 1301,
        "y" : 1183
      } ]
    }, {
      "id" : 59084,
      "points" : [ {
        "x" : 1301,
        "y" : 1210
      } ]
    } ],
    "outputs" : [ {
      "id" : 59104
    } ]
  }, {
    "id" : 59232,
    "reactomeId" : 10280056,
    "displayName" : "Vitronectin (VTN) binds to C5b:C6:C7",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 2563,
      "y" : 403
    },
    "minX" : 2557,
    "maxX" : 2569,
    "minY" : 376,
    "maxY" : 437,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 2563,
        "y" : 376
      },
      "to" : {
        "x" : 2563,
        "y" : 403
      }
    }, {
      "from" : {
        "x" : 2563,
        "y" : 403
      },
      "to" : {
        "x" : 2563,
        "y" : 437
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 2559,
        "y" : 430
      },
      "b" : {
        "x" : 2563,
        "y" : 437
      },
      "c" : {
        "x" : 2567,
        "y" : 430
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 2567,
        "y" : 430
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 2563,
        "y" : 403
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 2563,
        "y" : 403
      }
    },
    "inputs" : [ {
      "id" : 59233,
      "points" : [ {
        "x" : 2583,
        "y" : 362
      } ]
    }, {
      "id" : 59119,
      "points" : [ {
        "x" : 2555,
        "y" : 328
      } ]
    } ],
    "outputs" : [ {
      "id" : 59229
    } ]
  }, {
    "id" : 59105,
    "reactomeId" : 10241008,
    "displayName" : "Factor D cleaves C3b-bound Factor B",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 1580,
      "y" : 1183
    },
    "minX" : 1505,
    "maxX" : 1667,
    "minY" : 1174,
    "maxY" : 1198,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 1505,
        "y" : 1174
      },
      "to" : {
        "x" : 1580,
        "y" : 1183
      }
    }, {
      "from" : {
        "x" : 1580,
        "y" : 1183
      },
      "to" : {
        "x" : 1667,
        "y" : 1198
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 1574,
        "y" : 1177
      },
      "b" : {
        "x" : 1586,
        "y" : 1189
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 1580,
        "y" : 1183
      }
    },
    "inputs" : [ {
      "id" : 59104
    } ],
    "outputs" : [ {
      "id" : 59087,
      "points" : [ {
        "x" : 1699,
        "y" : 1240
      } ]
    }, {
      "id" : 59091,
      "points" : [ {
        "x" : 1691,
        "y" : 1180
      } ]
    } ],
    "catalysts" : [ {
      "id" : 59089,
      "points" : [ {
        "x" : 1573,
        "y" : 1206
      } ]
    } ]
  }, {
    "id" : 59106,
    "reactomeId" : 10239544,
    "displayName" : "Formation of classic pathway C5 convertase",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 2117,
      "y" : 219
    },
    "minX" : 2090,
    "maxX" : 2155,
    "minY" : 213,
    "maxY" : 244,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 2090,
        "y" : 219
      },
      "to" : {
        "x" : 2117,
        "y" : 219
      }
    }, {
      "from" : {
        "x" : 2117,
        "y" : 219
      },
      "to" : {
        "x" : 2155,
        "y" : 244
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 2147,
        "y" : 244
      },
      "b" : {
        "x" : 2155,
        "y" : 244
      },
      "c" : {
        "x" : 2151,
        "y" : 237
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 2151,
        "y" : 237
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 2117,
        "y" : 219
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 2117,
        "y" : 219
      }
    },
    "inputs" : [ {
      "id" : 59078,
      "points" : [ {
        "x" : 2005,
        "y" : 242
      } ]
    }, {
      "id" : 59107,
      "points" : [ {
        "x" : 2078,
        "y" : 244
      } ]
    } ],
    "outputs" : [ {
      "id" : 59108
    } ]
  }, {
    "id" : 59234,
    "reactomeId" : 10280942,
    "displayName" : "Hydrolysis of internal thioester in C4b",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 4727,
      "y" : 888
    },
    "minX" : 4721,
    "maxX" : 4733,
    "minY" : 856,
    "maxY" : 917,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 4726,
        "y" : 856
      },
      "to" : {
        "x" : 4727,
        "y" : 888
      }
    }, {
      "from" : {
        "x" : 4727,
        "y" : 888
      },
      "to" : {
        "x" : 4728,
        "y" : 917
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 4724,
        "y" : 910
      },
      "b" : {
        "x" : 4728,
        "y" : 917
      },
      "c" : {
        "x" : 4732,
        "y" : 910
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 4732,
        "y" : 910
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 4727,
        "y" : 888
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 4727,
        "y" : 888
      }
    },
    "inputs" : [ {
      "id" : 59235,
      "points" : [ {
        "x" : 4742,
        "y" : 845
      } ]
    }, {
      "id" : 59191,
      "points" : [ {
        "x" : 4684,
        "y" : 823
      } ]
    } ],
    "outputs" : [ {
      "id" : 59236
    } ]
  }, {
    "id" : 59109,
    "reactomeId" : 10239565,
    "displayName" : "Activation of C5",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 2318,
      "y" : 149
    },
    "minX" : 2216,
    "maxX" : 2374,
    "minY" : 83,
    "maxY" : 155,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 2216,
        "y" : 83
      },
      "to" : {
        "x" : 2318,
        "y" : 149
      }
    }, {
      "from" : {
        "x" : 2318,
        "y" : 149
      },
      "to" : {
        "x" : 2374,
        "y" : 149
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 2312,
        "y" : 143
      },
      "b" : {
        "x" : 2324,
        "y" : 155
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 2318,
        "y" : 149
      }
    },
    "inputs" : [ {
      "id" : 59110
    } ],
    "outputs" : [ {
      "id" : 59111,
      "points" : [ {
        "x" : 2377,
        "y" : 200
      } ]
    }, {
      "id" : 59112,
      "points" : [ {
        "x" : 2488,
        "y" : 149
      } ]
    } ],
    "catalysts" : [ {
      "id" : 59113,
      "points" : [ {
        "x" : 2280,
        "y" : 239
      } ]
    } ]
  }, {
    "id" : 59237,
    "reactomeId" : 10257377,
    "displayName" : "C3a receptor binds anaphylatoxin C3a",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 953,
      "y" : 1189
    },
    "minX" : 919,
    "maxX" : 989,
    "minY" : 1177,
    "maxY" : 1195,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 919,
        "y" : 1190
      },
      "to" : {
        "x" : 953,
        "y" : 1189
      }
    }, {
      "from" : {
        "x" : 953,
        "y" : 1189
      },
      "to" : {
        "x" : 989,
        "y" : 1177
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 984,
        "y" : 1183
      },
      "b" : {
        "x" : 989,
        "y" : 1177
      },
      "c" : {
        "x" : 981,
        "y" : 1175
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 981,
        "y" : 1175
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 953,
        "y" : 1189
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 953,
        "y" : 1189
      }
    },
    "inputs" : [ {
      "id" : 59098,
      "points" : [ {
        "x" : 904,
        "y" : 1207
      } ]
    }, {
      "id" : 59238,
      "points" : [ {
        "x" : 906,
        "y" : 1178
      } ]
    } ],
    "outputs" : [ {
      "id" : 59239
    } ]
  }, {
    "id" : 59240,
    "reactomeId" : 10307404,
    "displayName" : "C1-Inh binds Antigen: antibody: C1 complex activated C1r, C1s",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 1143,
      "y" : 203
    },
    "minX" : 1110,
    "maxX" : 1181,
    "minY" : 197,
    "maxY" : 231,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 1110,
        "y" : 203
      },
      "to" : {
        "x" : 1143,
        "y" : 203
      }
    }, {
      "from" : {
        "x" : 1143,
        "y" : 203
      },
      "to" : {
        "x" : 1181,
        "y" : 231
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 1173,
        "y" : 230
      },
      "b" : {
        "x" : 1181,
        "y" : 231
      },
      "c" : {
        "x" : 1178,
        "y" : 224
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 1178,
        "y" : 224
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 1143,
        "y" : 203
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 1143,
        "y" : 203
      }
    },
    "inputs" : [ {
      "id" : 59241,
      "points" : [ {
        "x" : 1066,
        "y" : 188
      } ],
      "stoichiometry" : 4
    }, {
      "id" : 59074,
      "points" : [ {
        "x" : 1091,
        "y" : 230
      } ]
    } ],
    "outputs" : [ {
      "id" : 59242
    } ]
  }, {
    "id" : 59114,
    "reactomeId" : 10239573,
    "displayName" : "C5b binds C6",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 2576,
      "y" : 141
    },
    "minX" : 2570,
    "maxX" : 2584,
    "minY" : 135,
    "maxY" : 169,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 2577,
        "y" : 141
      },
      "to" : {
        "x" : 2576,
        "y" : 141
      }
    }, {
      "from" : {
        "x" : 2576,
        "y" : 141
      },
      "to" : {
        "x" : 2584,
        "y" : 169
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 2578,
        "y" : 163
      },
      "b" : {
        "x" : 2584,
        "y" : 169
      },
      "c" : {
        "x" : 2586,
        "y" : 161
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 2586,
        "y" : 161
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 2576,
        "y" : 141
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 2576,
        "y" : 141
      }
    },
    "inputs" : [ {
      "id" : 59115,
      "points" : [ {
        "x" : 2557,
        "y" : 120
      } ]
    }, {
      "id" : 59112,
      "points" : [ {
        "x" : 2527,
        "y" : 147
      } ]
    } ],
    "outputs" : [ {
      "id" : 59116
    } ]
  }, {
    "id" : 59243,
    "reactomeId" : 10307463,
    "displayName" : "Antigen:IgG:C1Q:2xActivated C1R:SERPING1:2xActivated C1S:SERPING1 dissociates",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 1375,
      "y" : 204
    },
    "minX" : 1369,
    "maxX" : 1407,
    "minY" : 198,
    "maxY" : 219,
    "reactionType" : "dissociation",
    "segments" : [ {
      "from" : {
        "x" : 1370,
        "y" : 219
      },
      "to" : {
        "x" : 1375,
        "y" : 204
      }
    }, {
      "from" : {
        "x" : 1375,
        "y" : 204
      },
      "to" : {
        "x" : 1407,
        "y" : 205
      }
    } ],
    "reactionShape" : {
      "c" : {
        "x" : 1375,
        "y" : 204
      },
      "r" : 5,
      "r1" : 3,
      "type" : "DOUBLE_CIRCLE",
      "empty" : true,
      "centre" : {
        "x" : 1375,
        "y" : 204
      }
    },
    "inputs" : [ {
      "id" : 59244
    } ],
    "outputs" : [ {
      "id" : 59245,
      "points" : [ {
        "x" : 1313,
        "y" : 148
      } ],
      "stoichiometry" : 2
    }, {
      "id" : 59246,
      "points" : [ {
        "x" : 1371,
        "y" : 140
      } ]
    }, {
      "id" : 59247,
      "points" : [ {
        "x" : 1473,
        "y" : 243
      } ]
    }, {
      "id" : 59248,
      "points" : [ {
        "x" : 1431,
        "y" : 145
      } ],
      "stoichiometry" : 2
    } ]
  }, {
    "id" : 59117,
    "reactomeId" : 10239611,
    "displayName" : "C7 binds C5b:C6",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 2550,
      "y" : 239
    },
    "minX" : 2544,
    "maxX" : 2556,
    "minY" : 213,
    "maxY" : 299,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 2550,
        "y" : 213
      },
      "to" : {
        "x" : 2550,
        "y" : 239
      }
    }, {
      "from" : {
        "x" : 2550,
        "y" : 239
      },
      "to" : {
        "x" : 2553,
        "y" : 299
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 2549,
        "y" : 292
      },
      "b" : {
        "x" : 2553,
        "y" : 299
      },
      "c" : {
        "x" : 2557,
        "y" : 292
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 2557,
        "y" : 292
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 2550,
        "y" : 239
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 2550,
        "y" : 239
      }
    },
    "inputs" : [ {
      "id" : 59116,
      "points" : [ {
        "x" : 2573,
        "y" : 198
      } ]
    }, {
      "id" : 59118,
      "points" : [ {
        "x" : 2531,
        "y" : 200
      } ]
    } ],
    "outputs" : [ {
      "id" : 59119
    } ],
    "inhibitors" : [ {
      "id" : 59120,
      "points" : [ {
        "x" : 2634,
        "y" : 620
      }, {
        "x" : 2712,
        "y" : 547
      }, {
        "x" : 2713,
        "y" : 294
      } ]
    } ]
  }, {
    "id" : 59249,
    "reactomeId" : 10262708,
    "displayName" : "C5AR2 binds anaphylatoxins and thier desArginated derivatives",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 523,
      "y" : 1184
    },
    "minX" : 488,
    "maxX" : 558,
    "minY" : 1175,
    "maxY" : 1190,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 488,
        "y" : 1184
      },
      "to" : {
        "x" : 523,
        "y" : 1184
      }
    }, {
      "from" : {
        "x" : 523,
        "y" : 1184
      },
      "to" : {
        "x" : 558,
        "y" : 1175
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 552,
        "y" : 1181
      },
      "b" : {
        "x" : 558,
        "y" : 1175
      },
      "c" : {
        "x" : 550,
        "y" : 1173
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 550,
        "y" : 1173
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 523,
        "y" : 1184
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 523,
        "y" : 1184
      }
    },
    "inputs" : [ {
      "id" : 59250,
      "points" : [ {
        "x" : 461,
        "y" : 1174
      } ]
    }, {
      "id" : 59251,
      "points" : [ {
        "x" : 458,
        "y" : 1203
      } ]
    } ],
    "outputs" : [ {
      "id" : 59252
    } ]
  }, {
    "id" : 59121,
    "reactomeId" : 10239614,
    "displayName" : "C5b:C6:C7 translocates to the plasma membrane",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 2483,
      "y" : 492
    },
    "minX" : 2369,
    "maxX" : 2549,
    "minY" : 328,
    "maxY" : 498,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 2549,
        "y" : 328
      },
      "to" : {
        "x" : 2483,
        "y" : 492
      }
    }, {
      "from" : {
        "x" : 2483,
        "y" : 492
      },
      "to" : {
        "x" : 2369,
        "y" : 498
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 2477,
        "y" : 486
      },
      "b" : {
        "x" : 2489,
        "y" : 498
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 2483,
        "y" : 492
      }
    },
    "inputs" : [ {
      "id" : 59119
    } ],
    "inhibitors" : [ {
      "id" : 59120,
      "points" : [ {
        "x" : 2599,
        "y" : 620
      } ]
    } ]
  }, {
    "id" : 59122,
    "reactomeId" : 10239618,
    "displayName" : "C8 binds C5b:C6:C7",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 2361,
      "y" : 683
    },
    "minX" : 2343,
    "maxX" : 2367,
    "minY" : 546,
    "maxY" : 716,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 2362,
        "y" : 546
      },
      "to" : {
        "x" : 2361,
        "y" : 683
      }
    }, {
      "from" : {
        "x" : 2361,
        "y" : 683
      },
      "to" : {
        "x" : 2343,
        "y" : 716
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 2343,
        "y" : 708
      },
      "b" : {
        "x" : 2343,
        "y" : 716
      },
      "c" : {
        "x" : 2350,
        "y" : 712
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 2350,
        "y" : 712
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 2361,
        "y" : 683
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 2361,
        "y" : 683
      }
    },
    "inputs" : [ {
      "id" : 59123,
      "points" : [ {
        "x" : 2337,
        "y" : 516
      } ]
    }, {
      "id" : 59124,
      "points" : [ {
        "x" : 2369,
        "y" : 540
      } ]
    } ],
    "outputs" : [ {
      "id" : 59125
    } ],
    "inhibitors" : [ {
      "id" : 59120,
      "points" : [ {
        "x" : 2548,
        "y" : 651
      } ]
    } ]
  }, {
    "id" : 59253,
    "reactomeId" : 10307477,
    "displayName" : "CL-LK binds carbohydrates on target cell surface",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 206,
      "y" : 647
    },
    "minX" : 200,
    "maxX" : 229,
    "minY" : 595,
    "maxY" : 653,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 206,
        "y" : 595
      },
      "to" : {
        "x" : 206,
        "y" : 647
      }
    }, {
      "from" : {
        "x" : 206,
        "y" : 647
      },
      "to" : {
        "x" : 229,
        "y" : 647
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 222,
        "y" : 651
      },
      "b" : {
        "x" : 229,
        "y" : 647
      },
      "c" : {
        "x" : 222,
        "y" : 643
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 222,
        "y" : 643
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 206,
        "y" : 647
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 206,
        "y" : 647
      }
    },
    "inputs" : [ {
      "id" : 59254,
      "points" : [ {
        "x" : 261,
        "y" : 551
      } ]
    }, {
      "id" : 59255,
      "points" : [ {
        "x" : 184,
        "y" : 546
      } ],
      "stoichiometry" : 4
    }, {
      "id" : 59256,
      "points" : [ {
        "x" : 116,
        "y" : 567
      } ]
    } ],
    "outputs" : [ {
      "id" : 59257
    } ]
  }, {
    "id" : 59126,
    "reactomeId" : 10239622,
    "displayName" : "C9 binds C5b:C6:C7:C8",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 2435,
      "y" : 869
    },
    "minX" : 2355,
    "maxX" : 2441,
    "minY" : 810,
    "maxY" : 917,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 2438,
        "y" : 810
      },
      "to" : {
        "x" : 2435,
        "y" : 869
      }
    }, {
      "from" : {
        "x" : 2435,
        "y" : 869
      },
      "to" : {
        "x" : 2355,
        "y" : 917
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 2359,
        "y" : 910
      },
      "b" : {
        "x" : 2355,
        "y" : 917
      },
      "c" : {
        "x" : 2363,
        "y" : 917
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 2363,
        "y" : 917
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 2435,
        "y" : 869
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 2435,
        "y" : 869
      }
    },
    "inputs" : [ {
      "id" : 59127,
      "points" : [ {
        "x" : 2536,
        "y" : 743
      } ],
      "stoichiometry" : 12
    }, {
      "id" : 59125,
      "points" : [ {
        "x" : 2352,
        "y" : 745
      } ]
    } ],
    "outputs" : [ {
      "id" : 59128
    } ],
    "inhibitors" : [ {
      "id" : 59120,
      "points" : [ {
        "x" : 2616,
        "y" : 663
      }, {
        "x" : 2619,
        "y" : 739
      } ]
    } ]
  }, {
    "id" : 59129,
    "reactomeId" : 10263415,
    "displayName" : "C4b binds to cell surface",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 1829,
      "y" : 220
    },
    "minX" : 1782,
    "maxX" : 1849,
    "minY" : 214,
    "maxY" : 242,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 1782,
        "y" : 218
      },
      "to" : {
        "x" : 1829,
        "y" : 220
      }
    }, {
      "from" : {
        "x" : 1829,
        "y" : 220
      },
      "to" : {
        "x" : 1849,
        "y" : 242
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 1841,
        "y" : 240
      },
      "b" : {
        "x" : 1849,
        "y" : 242
      },
      "c" : {
        "x" : 1847,
        "y" : 234
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 1847,
        "y" : 234
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 1829,
        "y" : 220
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 1829,
        "y" : 220
      }
    },
    "inputs" : [ {
      "id" : 59130,
      "points" : [ {
        "x" : 1765,
        "y" : 145
      } ]
    }, {
      "id" : 59131,
      "points" : [ {
        "x" : 1756,
        "y" : 242
      } ]
    } ],
    "outputs" : [ {
      "id" : 59076
    } ]
  }, {
    "id" : 59258,
    "reactomeId" : 10249966,
    "displayName" : "C5a receptor binds C5a anaphylatoxin",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 2377,
      "y" : 375
    },
    "minX" : 2352,
    "maxX" : 2383,
    "minY" : 329,
    "maxY" : 391,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 2377,
        "y" : 329
      },
      "to" : {
        "x" : 2377,
        "y" : 375
      }
    }, {
      "from" : {
        "x" : 2377,
        "y" : 375
      },
      "to" : {
        "x" : 2352,
        "y" : 391
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 2356,
        "y" : 384
      },
      "b" : {
        "x" : 2352,
        "y" : 391
      },
      "c" : {
        "x" : 2360,
        "y" : 391
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 2360,
        "y" : 391
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 2377,
        "y" : 375
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 2377,
        "y" : 375
      }
    },
    "inputs" : [ {
      "id" : 59259,
      "points" : [ {
        "x" : 2345,
        "y" : 310
      } ]
    }, {
      "id" : 59111,
      "points" : [ {
        "x" : 2377,
        "y" : 229
      } ]
    } ],
    "outputs" : [ {
      "id" : 59260
    } ]
  }, {
    "id" : 59132,
    "reactomeId" : 10263395,
    "displayName" : "C3b binds to cell surface",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 1196,
      "y" : 1206
    },
    "minX" : 1145,
    "maxX" : 1248,
    "minY" : 1183,
    "maxY" : 1212,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 1145,
        "y" : 1207
      },
      "to" : {
        "x" : 1196,
        "y" : 1206
      }
    }, {
      "from" : {
        "x" : 1196,
        "y" : 1206
      },
      "to" : {
        "x" : 1248,
        "y" : 1183
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 1243,
        "y" : 1189
      },
      "b" : {
        "x" : 1248,
        "y" : 1183
      },
      "c" : {
        "x" : 1240,
        "y" : 1182
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 1240,
        "y" : 1182
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 1196,
        "y" : 1206
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 1196,
        "y" : 1206
      }
    },
    "inputs" : [ {
      "id" : 59099,
      "points" : [ {
        "x" : 910,
        "y" : 1272
      } ]
    }, {
      "id" : 59133,
      "points" : [ {
        "x" : 1136,
        "y" : 1177
      } ]
    } ],
    "outputs" : [ {
      "id" : 59103
    } ]
  }, {
    "id" : 59261,
    "reactomeId" : 10307496,
    "displayName" : "Clusterin binds C5b-C7, C8, C9",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 2614,
      "y" : 588
    },
    "minX" : 2608,
    "maxX" : 2620,
    "minY" : 550,
    "maxY" : 620,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 2616,
        "y" : 550
      },
      "to" : {
        "x" : 2614,
        "y" : 588
      }
    }, {
      "from" : {
        "x" : 2614,
        "y" : 588
      },
      "to" : {
        "x" : 2615,
        "y" : 620
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 2611,
        "y" : 613
      },
      "b" : {
        "x" : 2615,
        "y" : 620
      },
      "c" : {
        "x" : 2619,
        "y" : 613
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 2619,
        "y" : 613
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 2614,
        "y" : 588
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 2614,
        "y" : 588
      }
    },
    "inputs" : [ {
      "id" : 59262,
      "points" : [ {
        "x" : 2656,
        "y" : 517
      } ]
    }, {
      "id" : 59263,
      "points" : [ {
        "x" : 2594,
        "y" : 526
      } ]
    } ],
    "outputs" : [ {
      "id" : 59120
    } ]
  }, {
    "id" : 59134,
    "reactomeId" : 10263397,
    "displayName" : "C3 convertases spontaneously dissociate",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 2879,
      "y" : 226
    },
    "minX" : 2803,
    "maxX" : 2911,
    "minY" : 220,
    "maxY" : 266,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 2803,
        "y" : 266
      },
      "to" : {
        "x" : 2879,
        "y" : 226
      }
    }, {
      "from" : {
        "x" : 2879,
        "y" : 226
      },
      "to" : {
        "x" : 2911,
        "y" : 228
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 2873,
        "y" : 220
      },
      "b" : {
        "x" : 2885,
        "y" : 232
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 2879,
        "y" : 226
      }
    },
    "inputs" : [ {
      "id" : 59135
    } ],
    "outputs" : [ {
      "id" : 59136,
      "points" : [ {
        "x" : 3167,
        "y" : 274
      } ],
      "stoichiometry" : 3
    }, {
      "id" : 59137,
      "points" : [ {
        "x" : 2937,
        "y" : 198
      } ]
    }, {
      "id" : 59138,
      "points" : [ {
        "x" : 3054,
        "y" : 275
      } ]
    }, {
      "id" : 59139,
      "points" : [ {
        "x" : 2924,
        "y" : 274
      } ]
    }, {
      "id" : 59140,
      "points" : [ {
        "x" : 2991,
        "y" : 197
      } ]
    }, {
      "id" : 59141,
      "points" : [ {
        "x" : 3121,
        "y" : 226
      } ],
      "stoichiometry" : 3
    }, {
      "id" : 59142,
      "points" : [ {
        "x" : 3079,
        "y" : 193
      } ]
    } ]
  } ],
  "compartments" : [ {
    "id" : 59302,
    "reactomeId" : 70101,
    "displayName" : "cytosol",
    "schemaClass" : "Compartment",
    "renderableClass" : "Compartment",
    "position" : {
      "x" : 1311,
      "y" : 709
    },
    "minX" : 285,
    "maxX" : 2338,
    "minY" : 251,
    "maxY" : 1167,
    "prop" : {
      "x" : 285,
      "y" : 251,
      "width" : 2053,
      "height" : 916
    },
    "textPosition" : {
      "x" : 802,
      "y" : 497
    },
    "insets" : {
      "x" : 295,
      "y" : 261,
      "width" : 2033,
      "height" : 896
    },
    "bgColor" : {
      "r" : 250,
      "g" : 240,
      "b" : 240
    },
    "componentIds" : [ 59125, 59123, 59254, 59128, 59210, 59322, 59323, 59217, 59324, 59214, 59327, 59325, 59326, 59318, 59212, 59317, 59320, 59070, 59071, 59074, 59078, 59108, 59076, 59131, 59107, 59113, 59311, 59312, 59315, 59316, 59104, 59091, 59100, 59103, 59133, 59314, 59093, 59095, 59304, 59239, 59238, 59247, 59069, 59073, 59252, 59250, 59257, 59259, 59260, 59333, 59334, 59335, 59336, 59242, 59289, 59244, 59301, 59270 ]
  }, {
    "id" : 59303,
    "reactomeId" : 70101,
    "displayName" : "cytosol",
    "schemaClass" : "Compartment",
    "renderableClass" : "Compartment",
    "position" : {
      "x" : 3648,
      "y" : 691
    },
    "minX" : 2728,
    "maxX" : 4569,
    "minY" : 270,
    "maxY" : 1112,
    "prop" : {
      "x" : 2728,
      "y" : 270,
      "width" : 1841,
      "height" : 842
    },
    "textPosition" : {
      "x" : 2904,
      "y" : 407
    },
    "insets" : {
      "x" : 2738,
      "y" : 280,
      "width" : 1821,
      "height" : 822
    },
    "bgColor" : {
      "r" : 250,
      "g" : 240,
      "b" : 240
    },
    "componentIds" : [ 59154, 59153, 59149, 59151, 59192, 59170, 59221, 59220, 59184, 59187, 59227, 59155, 59181, 59176, 59177, 59179, 59204, 59222, 59305, 59308, 59309, 59310, 59186, 59183, 59169, 59168, 59172, 59173, 59136, 59135, 59226, 59138, 59139, 59225, 59147, 59150, 59163, 59164, 59165, 59332, 59331, 59272, 59273, 59190, 59194, 59200, 59207, 59199, 59274, 59283, 59201, 59277, 59275, 59276, 59285, 59284, 59337, 59287, 59288 ]
  } ],
  "notes" : [ {
    "id" : 59304,
    "displayName" : "Target Cell",
    "renderableClass" : "Note",
    "position" : {
      "x" : 834,
      "y" : 495
    },
    "minX" : 703,
    "maxX" : 965,
    "minY" : 470,
    "maxY" : 521,
    "prop" : {
      "x" : 703,
      "y" : 470,
      "width" : 262,
      "height" : 51
    },
    "textPosition" : {
      "x" : 796,
      "y" : 485
    },
    "fgColor" : {
      "r" : 0,
      "g" : 0,
      "b" : 0
    }
  }, {
    "id" : 59305,
    "displayName" : "Innocent bystander cell",
    "renderableClass" : "Note",
    "position" : {
      "x" : 2936,
      "y" : 397
    },
    "minX" : 2820,
    "maxX" : 3053,
    "minY" : 379,
    "maxY" : 416,
    "prop" : {
      "x" : 2820,
      "y" : 379,
      "width" : 233,
      "height" : 37
    },
    "textPosition" : {
      "x" : 2859,
      "y" : 387
    }
  } ],
  "links" : [ {
    "id" : 59328,
    "renderableClass" : "EntitySetAndMemberLink",
    "position" : {
      "x" : 2536,
      "y" : 539
    },
    "minX" : 2506,
    "maxX" : 2566,
    "minY" : 526,
    "maxY" : 553,
    "segments" : [ {
      "from" : {
        "x" : 2506,
        "y" : 553
      },
      "to" : {
        "x" : 2566,
        "y" : 526
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 2530,
        "y" : 533
      },
      "b" : {
        "x" : 2542,
        "y" : 545
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 2536,
        "y" : 539
      }
    },
    "inputs" : [ {
      "id" : 59230
    } ],
    "outputs" : [ {
      "id" : 59263
    } ]
  }, {
    "id" : 59329,
    "renderableClass" : "EntitySetAndMemberLink",
    "position" : {
      "x" : 2460,
      "y" : 523
    },
    "minX" : 2400,
    "maxX" : 2521,
    "minY" : 515,
    "maxY" : 532,
    "segments" : [ {
      "from" : {
        "x" : 2400,
        "y" : 532
      },
      "to" : {
        "x" : 2521,
        "y" : 515
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 2454,
        "y" : 517
      },
      "b" : {
        "x" : 2466,
        "y" : 529
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 2460,
        "y" : 523
      }
    },
    "inputs" : [ {
      "id" : 59124
    } ],
    "outputs" : [ {
      "id" : 59263
    } ]
  }, {
    "id" : 59330,
    "renderableClass" : "EntitySetAndMemberLink",
    "position" : {
      "x" : 2642,
      "y" : 403
    },
    "minX" : 2594,
    "maxX" : 2648,
    "minY" : 313,
    "maxY" : 497,
    "segments" : [ {
      "from" : {
        "x" : 2594,
        "y" : 313
      },
      "to" : {
        "x" : 2641,
        "y" : 313
      }
    }, {
      "from" : {
        "x" : 2641,
        "y" : 313
      },
      "to" : {
        "x" : 2643,
        "y" : 494
      }
    }, {
      "from" : {
        "x" : 2643,
        "y" : 494
      },
      "to" : {
        "x" : 2633,
        "y" : 497
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 2636,
        "y" : 397
      },
      "b" : {
        "x" : 2648,
        "y" : 409
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 2642,
        "y" : 403
      }
    },
    "inputs" : [ {
      "id" : 59119
    } ],
    "outputs" : [ {
      "id" : 59263
    } ]
  }, {
    "id" : 59331,
    "renderableClass" : "EntitySetAndMemberLink",
    "position" : {
      "x" : 3955,
      "y" : 693
    },
    "minX" : 3600,
    "maxX" : 4311,
    "minY" : 294,
    "maxY" : 1092,
    "segments" : [ {
      "from" : {
        "x" : 3600,
        "y" : 1092
      },
      "to" : {
        "x" : 4311,
        "y" : 294
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 3949,
        "y" : 687
      },
      "b" : {
        "x" : 3961,
        "y" : 699
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 3955,
        "y" : 693
      }
    },
    "inputs" : [ {
      "id" : 59222
    } ],
    "outputs" : [ {
      "id" : 59273
    } ]
  }, {
    "id" : 59332,
    "renderableClass" : "EntitySetAndEntitySetLink",
    "position" : {
      "x" : 4189,
      "y" : 690
    },
    "minX" : 4060,
    "maxX" : 4318,
    "minY" : 294,
    "maxY" : 1087,
    "segments" : [ {
      "from" : {
        "x" : 4318,
        "y" : 294
      },
      "to" : {
        "x" : 4060,
        "y" : 1087
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 4183,
        "y" : 684
      },
      "b" : {
        "x" : 4195,
        "y" : 696
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 4189,
        "y" : 690
      }
    },
    "inputs" : [ {
      "id" : 59273
    } ],
    "outputs" : [ {
      "id" : 59179
    } ]
  }, {
    "id" : 59333,
    "renderableClass" : "EntitySetAndEntitySetLink",
    "position" : {
      "x" : 403,
      "y" : 1281
    },
    "minX" : 371,
    "maxX" : 435,
    "minY" : 1238,
    "maxY" : 1324,
    "segments" : [ {
      "from" : {
        "x" : 371,
        "y" : 1324
      },
      "to" : {
        "x" : 435,
        "y" : 1238
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 397,
        "y" : 1275
      },
      "b" : {
        "x" : 409,
        "y" : 1287
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 403,
        "y" : 1281
      }
    },
    "inputs" : [ {
      "id" : 59279
    } ],
    "outputs" : [ {
      "id" : 59251
    } ]
  }, {
    "id" : 59334,
    "renderableClass" : "EntitySetAndEntitySetLink",
    "position" : {
      "x" : 483,
      "y" : 1278
    },
    "minX" : 452,
    "maxX" : 515,
    "minY" : 1238,
    "maxY" : 1318,
    "segments" : [ {
      "from" : {
        "x" : 515,
        "y" : 1318
      },
      "to" : {
        "x" : 452,
        "y" : 1238
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 477,
        "y" : 1272
      },
      "b" : {
        "x" : 489,
        "y" : 1284
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 483,
        "y" : 1278
      }
    },
    "inputs" : [ {
      "id" : 59280
    } ],
    "outputs" : [ {
      "id" : 59251
    } ]
  }, {
    "id" : 59336,
    "renderableClass" : "EntitySetAndMemberLink",
    "position" : {
      "x" : 4165,
      "y" : 786
    },
    "minX" : 3783,
    "maxX" : 4548,
    "minY" : 489,
    "maxY" : 1083,
    "segments" : [ {
      "from" : {
        "x" : 4548,
        "y" : 489
      },
      "to" : {
        "x" : 3783,
        "y" : 1083
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 4159,
        "y" : 780
      },
      "b" : {
        "x" : 4171,
        "y" : 792
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 4165,
        "y" : 786
      }
    },
    "inputs" : [ {
      "id" : 59285
    } ],
    "outputs" : [ {
      "id" : 59176
    } ]
  }, {
    "id" : 59337,
    "renderableClass" : "EntitySetAndMemberLink",
    "position" : {
      "x" : 4161,
      "y" : 831
    },
    "minX" : 3787,
    "maxX" : 4536,
    "minY" : 580,
    "maxY" : 1083,
    "segments" : [ {
      "from" : {
        "x" : 4536,
        "y" : 580
      },
      "to" : {
        "x" : 3787,
        "y" : 1083
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 4155,
        "y" : 825
      },
      "b" : {
        "x" : 4167,
        "y" : 837
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 4161,
        "y" : 831
      }
    },
    "inputs" : [ {
      "id" : 59288
    } ],
    "outputs" : [ {
      "id" : 59176
    } ]
  }, {
    "id" : 59308,
    "renderableClass" : "EntitySetAndMemberLink",
    "position" : {
      "x" : 3596,
      "y" : 690
    },
    "minX" : 3441,
    "maxX" : 3752,
    "minY" : 297,
    "maxY" : 1083,
    "segments" : [ {
      "from" : {
        "x" : 3441,
        "y" : 297
      },
      "to" : {
        "x" : 3752,
        "y" : 1083
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 3590,
        "y" : 684
      },
      "b" : {
        "x" : 3602,
        "y" : 696
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 3596,
        "y" : 690
      }
    },
    "inputs" : [ {
      "id" : 59172
    } ],
    "outputs" : [ {
      "id" : 59176
    } ]
  }, {
    "id" : 59309,
    "renderableClass" : "EntitySetAndMemberLink",
    "position" : {
      "x" : 3551,
      "y" : 690
    },
    "minX" : 3353,
    "maxX" : 3750,
    "minY" : 297,
    "maxY" : 1083,
    "segments" : [ {
      "from" : {
        "x" : 3353,
        "y" : 297
      },
      "to" : {
        "x" : 3750,
        "y" : 1083
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 3545,
        "y" : 684
      },
      "b" : {
        "x" : 3557,
        "y" : 696
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 3551,
        "y" : 690
      }
    },
    "inputs" : [ {
      "id" : 59173
    } ],
    "outputs" : [ {
      "id" : 59176
    } ]
  }, {
    "id" : 59310,
    "renderableClass" : "EntitySetAndMemberLink",
    "position" : {
      "x" : 3917,
      "y" : 690
    },
    "minX" : 3673,
    "maxX" : 4161,
    "minY" : 293,
    "maxY" : 1087,
    "segments" : [ {
      "from" : {
        "x" : 3673,
        "y" : 293
      },
      "to" : {
        "x" : 4161,
        "y" : 1087
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 3911,
        "y" : 684
      },
      "b" : {
        "x" : 3923,
        "y" : 696
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 3917,
        "y" : 690
      }
    },
    "inputs" : [ {
      "id" : 59168
    } ],
    "outputs" : [ {
      "id" : 59181
    } ]
  }, {
    "id" : 59311,
    "renderableClass" : "EntitySetAndMemberLink",
    "position" : {
      "x" : 2220,
      "y" : 256
    },
    "minX" : 2214,
    "maxX" : 2226,
    "minY" : 250,
    "maxY" : 262,
    "segments" : [ {
      "from" : {
        "x" : 2218,
        "y" : 256
      },
      "to" : {
        "x" : 2222,
        "y" : 256
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 2214,
        "y" : 250
      },
      "b" : {
        "x" : 2226,
        "y" : 262
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 2220,
        "y" : 256
      }
    },
    "inputs" : [ {
      "id" : 59108
    } ],
    "outputs" : [ {
      "id" : 59113
    } ]
  }, {
    "id" : 59312,
    "renderableClass" : "EntitySetAndMemberLink",
    "position" : {
      "x" : 2252,
      "y" : 706
    },
    "minX" : 2229,
    "maxX" : 2275,
    "minY" : 274,
    "maxY" : 1138,
    "segments" : [ {
      "from" : {
        "x" : 2229,
        "y" : 1138
      },
      "to" : {
        "x" : 2275,
        "y" : 274
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 2246,
        "y" : 700
      },
      "b" : {
        "x" : 2258,
        "y" : 712
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 2252,
        "y" : 706
      }
    },
    "inputs" : [ {
      "id" : 59095
    } ],
    "outputs" : [ {
      "id" : 59113
    } ]
  }, {
    "id" : 59313,
    "renderableClass" : "EntitySetAndMemberLink",
    "position" : {
      "x" : 783,
      "y" : 1322
    },
    "minX" : 748,
    "maxX" : 1664,
    "minY" : 1178,
    "maxY" : 1328,
    "segments" : [ {
      "from" : {
        "x" : 1664,
        "y" : 1327
      },
      "to" : {
        "x" : 783,
        "y" : 1322
      }
    }, {
      "from" : {
        "x" : 783,
        "y" : 1322
      },
      "to" : {
        "x" : 748,
        "y" : 1178
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 777,
        "y" : 1316
      },
      "b" : {
        "x" : 789,
        "y" : 1328
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 783,
        "y" : 1322
      }
    },
    "inputs" : [ {
      "id" : 59088
    } ],
    "outputs" : [ {
      "id" : 59100
    } ]
  }, {
    "id" : 59314,
    "renderableClass" : "EntitySetAndMemberLink",
    "position" : {
      "x" : 1343,
      "y" : 1119
    },
    "minX" : 801,
    "maxX" : 1696,
    "minY" : 1113,
    "maxY" : 1152,
    "segments" : [ {
      "from" : {
        "x" : 1696,
        "y" : 1151
      },
      "to" : {
        "x" : 1674,
        "y" : 1119
      }
    }, {
      "from" : {
        "x" : 1674,
        "y" : 1119
      },
      "to" : {
        "x" : 1012,
        "y" : 1119
      }
    }, {
      "from" : {
        "x" : 1012,
        "y" : 1119
      },
      "to" : {
        "x" : 801,
        "y" : 1152
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 1337,
        "y" : 1113
      },
      "b" : {
        "x" : 1349,
        "y" : 1125
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 1343,
        "y" : 1119
      }
    },
    "inputs" : [ {
      "id" : 59091
    } ],
    "outputs" : [ {
      "id" : 59100
    } ]
  }, {
    "id" : 59315,
    "renderableClass" : "EntitySetAndMemberLink",
    "position" : {
      "x" : 1460,
      "y" : 1095
    },
    "minX" : 793,
    "maxX" : 1990,
    "minY" : 1089,
    "maxY" : 1143,
    "segments" : [ {
      "from" : {
        "x" : 1990,
        "y" : 1139
      },
      "to" : {
        "x" : 1913,
        "y" : 1093
      }
    }, {
      "from" : {
        "x" : 1913,
        "y" : 1093
      },
      "to" : {
        "x" : 1008,
        "y" : 1097
      }
    }, {
      "from" : {
        "x" : 1008,
        "y" : 1097
      },
      "to" : {
        "x" : 793,
        "y" : 1143
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 1454,
        "y" : 1089
      },
      "b" : {
        "x" : 1466,
        "y" : 1101
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 1460,
        "y" : 1095
      }
    },
    "inputs" : [ {
      "id" : 59093
    } ],
    "outputs" : [ {
      "id" : 59100
    } ]
  }, {
    "id" : 59316,
    "renderableClass" : "EntitySetAndMemberLink",
    "position" : {
      "x" : 1356,
      "y" : 707
    },
    "minX" : 761,
    "maxX" : 1951,
    "minY" : 271,
    "maxY" : 1143,
    "segments" : [ {
      "from" : {
        "x" : 1951,
        "y" : 271
      },
      "to" : {
        "x" : 761,
        "y" : 1143
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 1350,
        "y" : 701
      },
      "b" : {
        "x" : 1362,
        "y" : 713
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 1356,
        "y" : 707
      }
    },
    "inputs" : [ {
      "id" : 59078
    } ],
    "outputs" : [ {
      "id" : 59100
    } ]
  }, {
    "id" : 59317,
    "renderableClass" : "EntitySetAndMemberLink",
    "position" : {
      "x" : 1458,
      "y" : 708
    },
    "minX" : 764,
    "maxX" : 2152,
    "minY" : 273,
    "maxY" : 1143,
    "segments" : [ {
      "from" : {
        "x" : 2152,
        "y" : 273
      },
      "to" : {
        "x" : 764,
        "y" : 1143
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 1452,
        "y" : 702
      },
      "b" : {
        "x" : 1464,
        "y" : 714
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 1458,
        "y" : 708
      }
    },
    "inputs" : [ {
      "id" : 59108
    } ],
    "outputs" : [ {
      "id" : 59100
    } ]
  }, {
    "id" : 59318,
    "renderableClass" : "EntitySetAndEntitySetLink",
    "position" : {
      "x" : 1510,
      "y" : 708
    },
    "minX" : 765,
    "maxX" : 2256,
    "minY" : 274,
    "maxY" : 1143,
    "segments" : [ {
      "from" : {
        "x" : 2256,
        "y" : 274
      },
      "to" : {
        "x" : 765,
        "y" : 1143
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 1504,
        "y" : 702
      },
      "b" : {
        "x" : 1516,
        "y" : 714
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 1510,
        "y" : 708
      }
    },
    "inputs" : [ {
      "id" : 59113
    } ],
    "outputs" : [ {
      "id" : 59100
    } ]
  }, {
    "id" : 59319,
    "renderableClass" : "EntitySetAndEntitySetLink",
    "position" : {
      "x" : 3305,
      "y" : 131
    },
    "minX" : 2797,
    "maxX" : 3750,
    "minY" : 125,
    "maxY" : 266,
    "segments" : [ {
      "from" : {
        "x" : 2797,
        "y" : 266
      },
      "to" : {
        "x" : 2953,
        "y" : 132
      }
    }, {
      "from" : {
        "x" : 2953,
        "y" : 132
      },
      "to" : {
        "x" : 3657,
        "y" : 131
      }
    }, {
      "from" : {
        "x" : 3657,
        "y" : 131
      },
      "to" : {
        "x" : 3750,
        "y" : 266
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 3299,
        "y" : 125
      },
      "b" : {
        "x" : 3311,
        "y" : 137
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 3305,
        "y" : 131
      }
    },
    "inputs" : [ {
      "id" : 59135
    } ],
    "outputs" : [ {
      "id" : 59169
    } ]
  }, {
    "id" : 59323,
    "renderableClass" : "EntitySetAndEntitySetLink",
    "position" : {
      "x" : 289,
      "y" : 841
    },
    "minX" : 283,
    "maxX" : 295,
    "minY" : 788,
    "maxY" : 894,
    "segments" : [ {
      "from" : {
        "x" : 291,
        "y" : 894
      },
      "to" : {
        "x" : 287,
        "y" : 788
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 283,
        "y" : 835
      },
      "b" : {
        "x" : 295,
        "y" : 847
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 289,
        "y" : 841
      }
    },
    "inputs" : [ {
      "id" : 59214
    } ],
    "outputs" : [ {
      "id" : 59210
    } ]
  } ],
  "shadows" : [ {
    "id" : 59338,
    "reactomeId" : 10329363,
    "displayName" : "Initial triggering of complement",
    "schemaClass" : "Pathway",
    "renderableClass" : "Shadow",
    "position" : {
      "x" : 1135,
      "y" : 722
    },
    "minX" : -10,
    "maxX" : 2281,
    "minY" : 16,
    "maxY" : 1429,
    "prop" : {
      "x" : -10,
      "y" : 16,
      "width" : 332,
      "height" : 1390
    },
    "points" : [ {
      "x" : -10,
      "y" : 16
    }, {
      "x" : 2281,
      "y" : 16
    }, {
      "x" : 2281,
      "y" : 1429
    }, {
      "x" : -10,
      "y" : 1429
    } ],
    "colour" : "#4684ee"
  }, {
    "id" : 59339,
    "reactomeId" : 10329367,
    "displayName" : "Activation of C3 and C5",
    "schemaClass" : "Pathway",
    "renderableClass" : "Shadow",
    "position" : {
      "x" : 1501,
      "y" : 790
    },
    "minX" : 469,
    "maxX" : 2534,
    "minY" : 45,
    "maxY" : 1535,
    "prop" : {
      "x" : 469,
      "y" : 1429,
      "width" : 2065,
      "height" : 106
    },
    "points" : [ {
      "x" : 469,
      "y" : 45
    }, {
      "x" : 2534,
      "y" : 45
    }, {
      "x" : 2534,
      "y" : 1535
    }, {
      "x" : 469,
      "y" : 1535
    } ],
    "colour" : "#dc3912"
  }, {
    "id" : 59340,
    "reactomeId" : 10329495,
    "displayName" : "Terminal pathway of complement",
    "schemaClass" : "Pathway",
    "renderableClass" : "Shadow",
    "position" : {
      "x" : 2476,
      "y" : 527
    },
    "minX" : 2260,
    "maxX" : 2692,
    "minY" : 88,
    "maxY" : 967,
    "prop" : {
      "x" : 2534,
      "y" : 88,
      "width" : 158,
      "height" : 879
    },
    "points" : [ {
      "x" : 2260,
      "y" : 88
    }, {
      "x" : 2692,
      "y" : 88
    }, {
      "x" : 2692,
      "y" : 967
    }, {
      "x" : 2260,
      "y" : 967
    } ],
    "colour" : "#008000"
  }, {
    "id" : 59341,
    "reactomeId" : 10330071,
    "displayName" : "Regulation of Complement cascade",
    "schemaClass" : "Pathway",
    "renderableClass" : "Shadow",
    "position" : {
      "x" : 2563,
      "y" : 698
    },
    "minX" : 322,
    "maxX" : 4805,
    "minY" : -10,
    "maxY" : 1406,
    "prop" : {
      "x" : 2692,
      "y" : 88,
      "width" : 2113,
      "height" : 879
    },
    "points" : [ {
      "x" : 322,
      "y" : -10
    }, {
      "x" : 4805,
      "y" : -10
    }, {
      "x" : 4805,
      "y" : 1406
    }, {
      "x" : 322,
      "y" : 1406
    } ],
    "colour" : "#666666"
  } ],
  "minX" : 0,
  "maxX" : 4825,
  "minY" : 0,
  "maxY" : 1525,
  "disease" : false
}