{
  "dbId" : 10329131,
  "stableId" : "R-CFA-76005",
  "displayName" : "Response to elevated platelet cytosolic Ca2+",
  "nodes" : [ {
    "id" : 52481,
    "reactomeId" : 10259564,
    "displayName" : "Platelet dense granule membrane components",
    "schemaClass" : "DefinedSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 321,
      "y" : 472
    },
    "minX" : 260,
    "maxX" : 383,
    "minY" : 447,
    "maxY" : 497,
    "prop" : {
      "x" : 260,
      "y" : 447,
      "width" : 123,
      "height" : 50
    },
    "textPosition" : {
      "x" : 270,
      "y" : 441
    },
    "connectors" : [ {
      "edgeId" : 52480,
      "type" : "INPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 52482,
    "reactomeId" : 10259570,
    "displayName" : "Platelet dense granule membrane components",
    "schemaClass" : "DefinedSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 143,
      "y" : 472
    },
    "minX" : 82,
    "maxX" : 205,
    "minY" : 447,
    "maxY" : 497,
    "prop" : {
      "x" : 82,
      "y" : 447,
      "width" : 123,
      "height" : 50
    },
    "textPosition" : {
      "x" : 92,
      "y" : 441
    },
    "connectors" : [ {
      "edgeId" : 52480,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 52484,
    "reactomeId" : 10259380,
    "displayName" : "Platelet alpha granule contents",
    "schemaClass" : "DefinedSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 336,
      "y" : 267
    },
    "minX" : 284,
    "maxX" : 388,
    "minY" : 249,
    "maxY" : 285,
    "prop" : {
      "x" : 284,
      "y" : 249,
      "width" : 104,
      "height" : 36
    },
    "textPosition" : {
      "x" : 286,
      "y" : 243
    },
    "connectors" : [ {
      "edgeId" : 52483,
      "type" : "INPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 52485,
    "reactomeId" : 10259472,
    "displayName" : "Platelet alpha granule contents",
    "schemaClass" : "DefinedSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 65,
      "y" : 266
    },
    "minX" : 13,
    "maxX" : 117,
    "minY" : 248,
    "maxY" : 284,
    "prop" : {
      "x" : 13,
      "y" : 248,
      "width" : 104,
      "height" : 36
    },
    "textPosition" : {
      "x" : 15,
      "y" : 242
    },
    "connectors" : [ {
      "edgeId" : 52483,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 52487,
    "reactomeId" : 10259626,
    "displayName" : "Platelet alpha granule membrane components that are released on degranulation",
    "schemaClass" : "DefinedSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 277,
      "y" : 197
    },
    "minX" : 201,
    "maxX" : 354,
    "minY" : 163,
    "maxY" : 232,
    "prop" : {
      "x" : 201,
      "y" : 163,
      "width" : 153,
      "height" : 69
    },
    "textPosition" : {
      "x" : 202,
      "y" : 159
    },
    "connectors" : [ {
      "edgeId" : 52486,
      "type" : "INPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 52488,
    "reactomeId" : 10259648,
    "displayName" : "Platelet alpha granule membrane components that are released on degranulation",
    "schemaClass" : "DefinedSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 66,
      "y" : 197
    },
    "minX" : 0,
    "maxX" : 132,
    "minY" : 158,
    "maxY" : 236,
    "prop" : {
      "x" : 0,
      "y" : 158,
      "width" : 132,
      "height" : 78
    },
    "textPosition" : {
      "x" : 0,
      "y" : 158
    },
    "connectors" : [ {
      "edgeId" : 52486,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 52490,
    "reactomeId" : 10259731,
    "displayName" : "Platelet releasate cytosolic proteins",
    "schemaClass" : "DefinedSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 274,
      "y" : 527
    },
    "minX" : 218,
    "maxX" : 330,
    "minY" : 509,
    "maxY" : 545,
    "prop" : {
      "x" : 218,
      "y" : 509,
      "width" : 112,
      "height" : 36
    },
    "textPosition" : {
      "x" : 238,
      "y" : 496
    },
    "connectors" : [ {
      "edgeId" : 52489,
      "type" : "INPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 52491,
    "reactomeId" : 10259765,
    "displayName" : "Platelet releasate cytosolic proteins",
    "schemaClass" : "DefinedSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 68,
      "y" : 525
    },
    "minX" : 12,
    "maxX" : 124,
    "minY" : 507,
    "maxY" : 543,
    "prop" : {
      "x" : 12,
      "y" : 507,
      "width" : 112,
      "height" : 36
    },
    "textPosition" : {
      "x" : 32,
      "y" : 494
    },
    "connectors" : [ {
      "edgeId" : 52489,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 52493,
    "reactomeId" : 10259687,
    "displayName" : "Platelet releasate secretory granule proteins",
    "schemaClass" : "DefinedSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 272,
      "y" : 708
    },
    "minX" : 216,
    "maxX" : 329,
    "minY" : 683,
    "maxY" : 733,
    "prop" : {
      "x" : 216,
      "y" : 683,
      "width" : 113,
      "height" : 50
    },
    "textPosition" : {
      "x" : 216,
      "y" : 677
    },
    "connectors" : [ {
      "edgeId" : 52492,
      "type" : "INPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 52494,
    "reactomeId" : 10259691,
    "displayName" : "Platelet releasate secretory granule proteins",
    "schemaClass" : "DefinedSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 69,
      "y" : 710
    },
    "minX" : 13,
    "maxX" : 126,
    "minY" : 685,
    "maxY" : 735,
    "prop" : {
      "x" : 13,
      "y" : 685,
      "width" : 113,
      "height" : 50
    },
    "textPosition" : {
      "x" : 13,
      "y" : 679
    },
    "connectors" : [ {
      "edgeId" : 52492,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 52496,
    "reactomeId" : 10248661,
    "displayName" : "PSAP,CHID1",
    "schemaClass" : "DefinedSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 561,
      "y" : 556
    },
    "minX" : 522,
    "maxX" : 600,
    "minY" : 545,
    "maxY" : 567,
    "prop" : {
      "x" : 522,
      "y" : 545,
      "width" : 78,
      "height" : 22
    },
    "textPosition" : {
      "x" : 538,
      "y" : 539
    },
    "connectors" : [ {
      "edgeId" : 52495,
      "type" : "INPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 52497,
    "reactomeId" : 10248667,
    "displayName" : "PSAP,CHID1",
    "schemaClass" : "DefinedSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 822,
      "y" : 552
    },
    "minX" : 783,
    "maxX" : 861,
    "minY" : 541,
    "maxY" : 563,
    "prop" : {
      "x" : 783,
      "y" : 541,
      "width" : 78,
      "height" : 22
    },
    "textPosition" : {
      "x" : 799,
      "y" : 535
    },
    "connectors" : [ {
      "edgeId" : 52495,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 52456,
    "reactomeId" : 114519,
    "displayName" : "DAG",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 477,
      "y" : 21
    },
    "minX" : 460,
    "maxX" : 517,
    "minY" : 9,
    "maxY" : 68,
    "prop" : {
      "x" : 460,
      "y" : 10,
      "width" : 35,
      "height" : 22
    },
    "textPosition" : {
      "x" : 460,
      "y" : 10
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 490,
          "y" : 15
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 490,
          "y" : 15
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 52455,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 476,
          "y" : 35
        },
        "to" : {
          "x" : 474,
          "y" : 68
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 52455,
      "type" : "ACTIVATOR",
      "segments" : [ {
        "from" : {
          "x" : 488,
          "y" : 35
        },
        "to" : {
          "x" : 517,
          "y" : 61
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 509,
          "y" : 59
        },
        "b" : {
          "x" : 517,
          "y" : 61
        },
        "c" : {
          "x" : 515,
          "y" : 53
        },
        "type" : "ARROW",
        "empty" : true,
        "centre" : {
          "x" : 515,
          "y" : 53
        }
      }
    } ]
  }, {
    "id" : 52457,
    "reactomeId" : 10234855,
    "displayName" : "Protein Kinase C, conventional",
    "schemaClass" : "DefinedSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 343,
      "y" : 26
    },
    "minX" : 288,
    "maxX" : 474,
    "minY" : 8,
    "maxY" : 68,
    "prop" : {
      "x" : 288,
      "y" : 8,
      "width" : 111,
      "height" : 36
    },
    "textPosition" : {
      "x" : 291,
      "y" : 8
    },
    "connectors" : [ {
      "edgeId" : 52455,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 405,
          "y" : 43
        },
        "to" : {
          "x" : 474,
          "y" : 68
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 52458,
    "reactomeId" : 74016,
    "displayName" : "Ca2+",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 347,
      "y" : 92
    },
    "minX" : 322,
    "maxX" : 474,
    "minY" : 68,
    "maxY" : 107,
    "prop" : {
      "x" : 322,
      "y" : 77,
      "width" : 50,
      "height" : 30
    },
    "textPosition" : {
      "x" : 326,
      "y" : 81
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 367,
          "y" : 82
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 367,
          "y" : 82
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 52455,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 375,
          "y" : 87
        },
        "to" : {
          "x" : 474,
          "y" : 68
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 52459,
    "reactomeId" : 33625,
    "displayName" : "PS",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 213,
      "y" : 27
    },
    "minX" : 155,
    "maxX" : 474,
    "minY" : 15,
    "maxY" : 68,
    "prop" : {
      "x" : 155,
      "y" : 16,
      "width" : 117,
      "height" : 22
    },
    "textPosition" : {
      "x" : 201,
      "y" : 16
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 267,
          "y" : 21
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 267,
          "y" : 21
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 52455,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 224,
          "y" : 41
        },
        "to" : {
          "x" : 256,
          "y" : 68
        }
      }, {
        "from" : {
          "x" : 256,
          "y" : 68
        },
        "to" : {
          "x" : 474,
          "y" : 68
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 52460,
    "reactomeId" : 10234867,
    "displayName" : "Activated conventional protein kinase C",
    "schemaClass" : "DefinedSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 630,
      "y" : 25
    },
    "minX" : 566,
    "maxX" : 695,
    "minY" : 0,
    "maxY" : 236,
    "prop" : {
      "x" : 566,
      "y" : 0,
      "width" : 129,
      "height" : 50
    },
    "textPosition" : {
      "x" : 575,
      "y" : 0
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "connectors" : [ {
      "edgeId" : 52466,
      "type" : "CATALYST",
      "segments" : [ {
        "from" : {
          "x" : 622,
          "y" : 56
        },
        "to" : {
          "x" : 580,
          "y" : 187
        }
      }, {
        "from" : {
          "x" : 580,
          "y" : 187
        },
        "to" : {
          "x" : 593,
          "y" : 228
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 594,
          "y" : 232
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 594,
          "y" : 232
        }
      }
    }, {
      "edgeId" : 52455,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 52461,
      "type" : "CATALYST",
      "segments" : [ {
        "from" : {
          "x" : 625,
          "y" : 56
        },
        "to" : {
          "x" : 603,
          "y" : 159
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 602,
          "y" : 163
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 602,
          "y" : 163
        }
      }
    } ]
  }, {
    "id" : 52462,
    "reactomeId" : 10234971,
    "displayName" : "STXBP3",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 530,
      "y" : 128
    },
    "minX" : 496,
    "maxX" : 573,
    "minY" : 110,
    "maxY" : 175,
    "prop" : {
      "x" : 496,
      "y" : 116,
      "width" : 68,
      "height" : 24
    },
    "textPosition" : {
      "x" : 503,
      "y" : 117
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 564,
          "y" : 116
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 564,
          "y" : 116
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 52461,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 540,
          "y" : 143
        },
        "to" : {
          "x" : 573,
          "y" : 175
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 52463,
    "reactomeId" : 113592,
    "displayName" : "ATP",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 541,
      "y" : 207
    },
    "minX" : 521,
    "maxX" : 573,
    "minY" : 175,
    "maxY" : 243,
    "prop" : {
      "x" : 521,
      "y" : 192,
      "width" : 40,
      "height" : 30
    },
    "textPosition" : {
      "x" : 525,
      "y" : 196
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 556,
          "y" : 197
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 556,
          "y" : 197
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 52466,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 549,
          "y" : 225
        },
        "to" : {
          "x" : 561,
          "y" : 243
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 52461,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 556,
          "y" : 189
        },
        "to" : {
          "x" : 573,
          "y" : 175
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 52464,
    "reactomeId" : 10234974,
    "displayName" : "phospho-STXBP3",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 666,
      "y" : 132
    },
    "minX" : 626,
    "maxX" : 712,
    "minY" : 109,
    "maxY" : 175,
    "prop" : {
      "x" : 626,
      "y" : 115,
      "width" : 80,
      "height" : 34
    },
    "textPosition" : {
      "x" : 632,
      "y" : 115
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 706,
          "y" : 115
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 706,
          "y" : 115
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 52461,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 650,
          "y" : 152
        },
        "to" : {
          "x" : 626,
          "y" : 175
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 648,
          "y" : 160
        },
        "b" : {
          "x" : 650,
          "y" : 152
        },
        "c" : {
          "x" : 642,
          "y" : 154
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 642,
          "y" : 154
        }
      }
    } ]
  }, {
    "id" : 52465,
    "reactomeId" : 29370,
    "displayName" : "ADP",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 671,
      "y" : 204
    },
    "minX" : 626,
    "maxX" : 693,
    "minY" : 175,
    "maxY" : 243,
    "prop" : {
      "x" : 651,
      "y" : 189,
      "width" : 41,
      "height" : 30
    },
    "textPosition" : {
      "x" : 655,
      "y" : 193
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 687,
          "y" : 194
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 687,
          "y" : 194
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 52466,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 657,
          "y" : 222
        },
        "to" : {
          "x" : 635,
          "y" : 243
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 655,
          "y" : 230
        },
        "b" : {
          "x" : 657,
          "y" : 222
        },
        "c" : {
          "x" : 649,
          "y" : 224
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 649,
          "y" : 224
        }
      }
    }, {
      "edgeId" : 52461,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 648,
          "y" : 190
        },
        "to" : {
          "x" : 626,
          "y" : 175
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 640,
          "y" : 189
        },
        "b" : {
          "x" : 648,
          "y" : 190
        },
        "c" : {
          "x" : 645,
          "y" : 183
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 645,
          "y" : 183
        }
      }
    } ]
  }, {
    "id" : 52467,
    "reactomeId" : 10234981,
    "displayName" : "STX4",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 538,
      "y" : 292
    },
    "minX" : 504,
    "maxX" : 578,
    "minY" : 243,
    "maxY" : 303,
    "prop" : {
      "x" : 504,
      "y" : 281,
      "width" : 68,
      "height" : 22
    },
    "textPosition" : {
      "x" : 519,
      "y" : 281
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 572,
          "y" : 281
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 572,
          "y" : 281
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 52466,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 543,
          "y" : 278
        },
        "to" : {
          "x" : 561,
          "y" : 243
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 52468,
    "reactomeId" : 10234984,
    "displayName" : "phospho-STX4",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 669,
      "y" : 284
    },
    "minX" : 632,
    "maxX" : 712,
    "minY" : 243,
    "maxY" : 296,
    "prop" : {
      "x" : 632,
      "y" : 273,
      "width" : 74,
      "height" : 23
    },
    "textPosition" : {
      "x" : 635,
      "y" : 267
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 706,
          "y" : 273
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 706,
          "y" : 273
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 52466,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 659,
          "y" : 270
        },
        "to" : {
          "x" : 635,
          "y" : 243
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 651,
          "y" : 267
        },
        "b" : {
          "x" : 659,
          "y" : 270
        },
        "c" : {
          "x" : 657,
          "y" : 262
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 657,
          "y" : 262
        }
      }
    } ]
  }, {
    "id" : 52470,
    "reactomeId" : 29356,
    "displayName" : "H2O",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 645,
      "y" : 359
    },
    "minX" : 575,
    "maxX" : 668,
    "minY" : 343,
    "maxY" : 403,
    "prop" : {
      "x" : 624,
      "y" : 344,
      "width" : 43,
      "height" : 31
    },
    "textPosition" : {
      "x" : 628,
      "y" : 349
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 662,
          "y" : 349
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 662,
          "y" : 349
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 52469,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 621,
          "y" : 372
        },
        "to" : {
          "x" : 575,
          "y" : 403
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ],
    "trivial" : true
  }, {
    "id" : 52471,
    "reactomeId" : 29370,
    "displayName" : "ADP",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 632,
      "y" : 403
    },
    "minX" : 575,
    "maxX" : 654,
    "minY" : 387,
    "maxY" : 419,
    "prop" : {
      "x" : 612,
      "y" : 388,
      "width" : 41,
      "height" : 31
    },
    "textPosition" : {
      "x" : 616,
      "y" : 393
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 648,
          "y" : 393
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 648,
          "y" : 393
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 52469,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 609,
          "y" : 403
        },
        "to" : {
          "x" : 575,
          "y" : 403
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 52472,
    "reactomeId" : 113592,
    "displayName" : "ATP",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 599,
      "y" : 352
    },
    "minX" : 575,
    "maxX" : 620,
    "minY" : 336,
    "maxY" : 403,
    "prop" : {
      "x" : 579,
      "y" : 337,
      "width" : 40,
      "height" : 31
    },
    "textPosition" : {
      "x" : 583,
      "y" : 342
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 614,
          "y" : 342
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 614,
          "y" : 342
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 52469,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 591,
          "y" : 371
        },
        "to" : {
          "x" : 575,
          "y" : 403
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 52473,
    "reactomeId" : 114565,
    "displayName" : "ADP",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 469,
      "y" : 428
    },
    "minX" : 449,
    "maxX" : 538,
    "minY" : 412,
    "maxY" : 444,
    "prop" : {
      "x" : 449,
      "y" : 413,
      "width" : 41,
      "height" : 31
    },
    "textPosition" : {
      "x" : 453,
      "y" : 418
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 485,
          "y" : 418
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 485,
          "y" : 418
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 52469,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 493,
          "y" : 428
        },
        "to" : {
          "x" : 538,
          "y" : 428
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 500,
          "y" : 424
        },
        "b" : {
          "x" : 493,
          "y" : 428
        },
        "c" : {
          "x" : 500,
          "y" : 432
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 500,
          "y" : 432
        }
      }
    } ]
  }, {
    "id" : 52474,
    "reactomeId" : 70106,
    "displayName" : "H+",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 581,
      "y" : 468
    },
    "minX" : 538,
    "maxX" : 599,
    "minY" : 428,
    "maxY" : 484,
    "prop" : {
      "x" : 564,
      "y" : 453,
      "width" : 34,
      "height" : 31
    },
    "textPosition" : {
      "x" : 567,
      "y" : 458
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 593,
          "y" : 458
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 593,
          "y" : 458
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 52469,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 564,
          "y" : 450
        },
        "to" : {
          "x" : 538,
          "y" : 428
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 556,
          "y" : 449
        },
        "b" : {
          "x" : 564,
          "y" : 450
        },
        "c" : {
          "x" : 561,
          "y" : 442
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 561,
          "y" : 442
        }
      }
    } ],
    "trivial" : true
  }, {
    "id" : 52475,
    "reactomeId" : 29372,
    "displayName" : "Pi",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 617,
      "y" : 444
    },
    "minX" : 538,
    "maxX" : 632,
    "minY" : 428,
    "maxY" : 460,
    "prop" : {
      "x" : 604,
      "y" : 429,
      "width" : 27,
      "height" : 31
    },
    "textPosition" : {
      "x" : 608,
      "y" : 434
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 626,
          "y" : 434
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 626,
          "y" : 434
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 52469,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 601,
          "y" : 441
        },
        "to" : {
          "x" : 538,
          "y" : 428
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 593,
          "y" : 444
        },
        "b" : {
          "x" : 601,
          "y" : 441
        },
        "c" : {
          "x" : 595,
          "y" : 436
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 595,
          "y" : 436
        }
      }
    } ]
  }, {
    "id" : 52476,
    "reactomeId" : 10256101,
    "displayName" : "Abcc4",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 538,
      "y" : 353
    },
    "minX" : 514,
    "maxX" : 568,
    "minY" : 336,
    "maxY" : 395,
    "prop" : {
      "x" : 514,
      "y" : 342,
      "width" : 48,
      "height" : 22
    },
    "textPosition" : {
      "x" : 515,
      "y" : 342
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 562,
          "y" : 342
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 562,
          "y" : 342
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 52469,
      "type" : "CATALYST",
      "segments" : [ {
        "from" : {
          "x" : 538,
          "y" : 367
        },
        "to" : {
          "x" : 538,
          "y" : 387
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 538,
          "y" : 391
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 538,
          "y" : 391
        }
      }
    } ]
  }, {
    "id" : 52478,
    "reactomeId" : 10259524,
    "displayName" : "Platelet dense granule content",
    "schemaClass" : "DefinedSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 328,
      "y" : 394
    },
    "minX" : 275,
    "maxX" : 381,
    "minY" : 372,
    "maxY" : 416,
    "prop" : {
      "x" : 275,
      "y" : 372,
      "width" : 106,
      "height" : 44
    },
    "textPosition" : {
      "x" : 276,
      "y" : 370
    },
    "connectors" : [ {
      "edgeId" : 52477,
      "type" : "INPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 52479,
    "reactomeId" : 10259550,
    "displayName" : "Platelet dense granule content",
    "schemaClass" : "DefinedSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 71,
      "y" : 394
    },
    "minX" : 22,
    "maxX" : 120,
    "minY" : 376,
    "maxY" : 412,
    "prop" : {
      "x" : 22,
      "y" : 376,
      "width" : 98,
      "height" : 36
    },
    "textPosition" : {
      "x" : 41,
      "y" : 363
    },
    "connectors" : [ {
      "edgeId" : 52477,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  } ],
  "edges" : [ {
    "id" : 52480,
    "reactomeId" : 10259572,
    "displayName" : "Surface deployment of platelet dense granule membrane components",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 229,
      "y" : 471
    },
    "minX" : 211,
    "maxX" : 254,
    "minY" : 465,
    "maxY" : 477,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 254,
        "y" : 471
      },
      "to" : {
        "x" : 229,
        "y" : 471
      }
    }, {
      "from" : {
        "x" : 229,
        "y" : 471
      },
      "to" : {
        "x" : 211,
        "y" : 471
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 218,
        "y" : 467
      },
      "b" : {
        "x" : 211,
        "y" : 471
      },
      "c" : {
        "x" : 218,
        "y" : 475
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 218,
        "y" : 475
      }
    },
    "reactionShape" : {
      "a" : {
        "x" : 223,
        "y" : 465
      },
      "b" : {
        "x" : 235,
        "y" : 477
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 229,
        "y" : 471
      }
    },
    "inputs" : [ {
      "id" : 52481
    } ],
    "outputs" : [ {
      "id" : 52482
    } ]
  }, {
    "id" : 52466,
    "reactomeId" : 10234986,
    "displayName" : "Phosphorylation of Syntaxin-4",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 598,
      "y" : 243
    },
    "minX" : 561,
    "maxX" : 635,
    "minY" : 237,
    "maxY" : 249,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 561,
        "y" : 243
      },
      "to" : {
        "x" : 598,
        "y" : 243
      }
    }, {
      "from" : {
        "x" : 598,
        "y" : 243
      },
      "to" : {
        "x" : 635,
        "y" : 243
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 592,
        "y" : 237
      },
      "b" : {
        "x" : 604,
        "y" : 249
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 598,
        "y" : 243
      }
    },
    "inputs" : [ {
      "id" : 52467,
      "points" : [ {
        "x" : 543,
        "y" : 278
      } ]
    }, {
      "id" : 52463,
      "points" : [ {
        "x" : 549,
        "y" : 225
      } ]
    } ],
    "outputs" : [ {
      "id" : 52468,
      "points" : [ {
        "x" : 659,
        "y" : 270
      } ]
    }, {
      "id" : 52465,
      "points" : [ {
        "x" : 657,
        "y" : 222
      } ]
    } ],
    "catalysts" : [ {
      "id" : 52460,
      "points" : [ {
        "x" : 622,
        "y" : 56
      }, {
        "x" : 580,
        "y" : 187
      } ]
    } ]
  }, {
    "id" : 52483,
    "reactomeId" : 10259474,
    "displayName" : "Exocytosis of platelet alpha granule contents",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 193,
      "y" : 266
    },
    "minX" : 123,
    "maxX" : 278,
    "minY" : 260,
    "maxY" : 272,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 278,
        "y" : 266
      },
      "to" : {
        "x" : 193,
        "y" : 266
      }
    }, {
      "from" : {
        "x" : 193,
        "y" : 266
      },
      "to" : {
        "x" : 123,
        "y" : 266
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 130,
        "y" : 262
      },
      "b" : {
        "x" : 123,
        "y" : 266
      },
      "c" : {
        "x" : 130,
        "y" : 270
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 130,
        "y" : 270
      }
    },
    "reactionShape" : {
      "a" : {
        "x" : 187,
        "y" : 260
      },
      "b" : {
        "x" : 199,
        "y" : 272
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 193,
        "y" : 266
      }
    },
    "inputs" : [ {
      "id" : 52484
    } ],
    "outputs" : [ {
      "id" : 52485
    } ]
  }, {
    "id" : 52469,
    "reactomeId" : 10256104,
    "displayName" : "ABCC4 accumulation of dense granule contents",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 538,
      "y" : 403
    },
    "minX" : 532,
    "maxX" : 575,
    "minY" : 397,
    "maxY" : 428,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 575,
        "y" : 403
      },
      "to" : {
        "x" : 538,
        "y" : 403
      }
    }, {
      "from" : {
        "x" : 538,
        "y" : 403
      },
      "to" : {
        "x" : 538,
        "y" : 428
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 532,
        "y" : 397
      },
      "b" : {
        "x" : 544,
        "y" : 409
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 538,
        "y" : 403
      }
    },
    "inputs" : [ {
      "id" : 52470,
      "points" : [ {
        "x" : 621,
        "y" : 372
      } ]
    }, {
      "id" : 52471,
      "points" : [ {
        "x" : 609,
        "y" : 403
      } ]
    }, {
      "id" : 52472,
      "points" : [ {
        "x" : 591,
        "y" : 371
      } ]
    } ],
    "outputs" : [ {
      "id" : 52473,
      "points" : [ {
        "x" : 493,
        "y" : 428
      } ]
    }, {
      "id" : 52474,
      "points" : [ {
        "x" : 564,
        "y" : 450
      } ]
    }, {
      "id" : 52475,
      "points" : [ {
        "x" : 601,
        "y" : 441
      } ]
    } ],
    "catalysts" : [ {
      "id" : 52476,
      "points" : [ {
        "x" : 538,
        "y" : 367
      } ]
    } ]
  }, {
    "id" : 52486,
    "reactomeId" : 10259650,
    "displayName" : "Surface deployment of platelet alpha granule membrane components",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 170,
      "y" : 199
    },
    "minX" : 138,
    "maxX" : 195,
    "minY" : 193,
    "maxY" : 205,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 195,
        "y" : 198
      },
      "to" : {
        "x" : 170,
        "y" : 199
      }
    }, {
      "from" : {
        "x" : 170,
        "y" : 199
      },
      "to" : {
        "x" : 138,
        "y" : 198
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 145,
        "y" : 194
      },
      "b" : {
        "x" : 138,
        "y" : 198
      },
      "c" : {
        "x" : 145,
        "y" : 202
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 145,
        "y" : 202
      }
    },
    "reactionShape" : {
      "a" : {
        "x" : 164,
        "y" : 193
      },
      "b" : {
        "x" : 176,
        "y" : 205
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 170,
        "y" : 199
      }
    },
    "inputs" : [ {
      "id" : 52487
    } ],
    "outputs" : [ {
      "id" : 52488
    } ]
  }, {
    "id" : 52455,
    "reactomeId" : 10234869,
    "displayName" : "Activation of conventional Protein Kinase C",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 524,
      "y" : 67
    },
    "minX" : 474,
    "maxX" : 566,
    "minY" : 56,
    "maxY" : 73,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 474,
        "y" : 68
      },
      "to" : {
        "x" : 524,
        "y" : 67
      }
    }, {
      "from" : {
        "x" : 524,
        "y" : 67
      },
      "to" : {
        "x" : 566,
        "y" : 56
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 560,
        "y" : 62
      },
      "b" : {
        "x" : 566,
        "y" : 56
      },
      "c" : {
        "x" : 558,
        "y" : 54
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 558,
        "y" : 54
      }
    },
    "reactionShape" : {
      "a" : {
        "x" : 518,
        "y" : 61
      },
      "b" : {
        "x" : 530,
        "y" : 73
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 524,
        "y" : 67
      }
    },
    "inputs" : [ {
      "id" : 52456,
      "points" : [ {
        "x" : 476,
        "y" : 35
      } ]
    }, {
      "id" : 52457,
      "points" : [ {
        "x" : 405,
        "y" : 43
      } ]
    }, {
      "id" : 52458,
      "points" : [ {
        "x" : 375,
        "y" : 87
      } ]
    }, {
      "id" : 52459,
      "points" : [ {
        "x" : 224,
        "y" : 41
      }, {
        "x" : 256,
        "y" : 68
      } ]
    } ],
    "outputs" : [ {
      "id" : 52460
    } ],
    "activators" : [ {
      "id" : 52456,
      "points" : [ {
        "x" : 488,
        "y" : 35
      } ]
    } ]
  }, {
    "id" : 52489,
    "reactomeId" : 10259767,
    "displayName" : "Release of platelet cytosolic components",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 192,
      "y" : 525
    },
    "minX" : 130,
    "maxX" : 212,
    "minY" : 519,
    "maxY" : 531,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 212,
        "y" : 525
      },
      "to" : {
        "x" : 192,
        "y" : 525
      }
    }, {
      "from" : {
        "x" : 192,
        "y" : 525
      },
      "to" : {
        "x" : 130,
        "y" : 525
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 137,
        "y" : 521
      },
      "b" : {
        "x" : 130,
        "y" : 525
      },
      "c" : {
        "x" : 137,
        "y" : 529
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 137,
        "y" : 529
      }
    },
    "reactionShape" : {
      "a" : {
        "x" : 186,
        "y" : 519
      },
      "b" : {
        "x" : 198,
        "y" : 531
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 192,
        "y" : 525
      }
    },
    "inputs" : [ {
      "id" : 52490
    } ],
    "outputs" : [ {
      "id" : 52491
    } ]
  }, {
    "id" : 52492,
    "reactomeId" : 10259693,
    "displayName" : "Release of platelet secretory granule components",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 173,
      "y" : 708
    },
    "minX" : 132,
    "maxX" : 210,
    "minY" : 702,
    "maxY" : 714,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 210,
        "y" : 708
      },
      "to" : {
        "x" : 173,
        "y" : 708
      }
    }, {
      "from" : {
        "x" : 173,
        "y" : 708
      },
      "to" : {
        "x" : 132,
        "y" : 708
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 139,
        "y" : 704
      },
      "b" : {
        "x" : 132,
        "y" : 708
      },
      "c" : {
        "x" : 139,
        "y" : 712
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 139,
        "y" : 712
      }
    },
    "reactionShape" : {
      "a" : {
        "x" : 167,
        "y" : 702
      },
      "b" : {
        "x" : 179,
        "y" : 714
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 173,
        "y" : 708
      }
    },
    "inputs" : [ {
      "id" : 52493
    } ],
    "outputs" : [ {
      "id" : 52494
    } ]
  }, {
    "id" : 52477,
    "reactomeId" : 10259552,
    "displayName" : "Exocytosis of platelet dense granule content",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 194,
      "y" : 395
    },
    "minX" : 126,
    "maxX" : 269,
    "minY" : 389,
    "maxY" : 401,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 269,
        "y" : 394
      },
      "to" : {
        "x" : 194,
        "y" : 395
      }
    }, {
      "from" : {
        "x" : 194,
        "y" : 395
      },
      "to" : {
        "x" : 126,
        "y" : 394
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 133,
        "y" : 390
      },
      "b" : {
        "x" : 126,
        "y" : 394
      },
      "c" : {
        "x" : 133,
        "y" : 398
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 133,
        "y" : 398
      }
    },
    "reactionShape" : {
      "a" : {
        "x" : 188,
        "y" : 389
      },
      "b" : {
        "x" : 200,
        "y" : 401
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 194,
        "y" : 395
      }
    },
    "inputs" : [ {
      "id" : 52478
    } ],
    "outputs" : [ {
      "id" : 52479
    } ]
  }, {
    "id" : 52461,
    "reactomeId" : 10234977,
    "displayName" : "Phosphorylation of Platelet Sec-1",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 600,
      "y" : 175
    },
    "minX" : 573,
    "maxX" : 626,
    "minY" : 169,
    "maxY" : 181,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 573,
        "y" : 175
      },
      "to" : {
        "x" : 600,
        "y" : 175
      }
    }, {
      "from" : {
        "x" : 600,
        "y" : 175
      },
      "to" : {
        "x" : 626,
        "y" : 175
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 594,
        "y" : 169
      },
      "b" : {
        "x" : 606,
        "y" : 181
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 600,
        "y" : 175
      }
    },
    "inputs" : [ {
      "id" : 52462,
      "points" : [ {
        "x" : 540,
        "y" : 143
      } ]
    }, {
      "id" : 52463,
      "points" : [ {
        "x" : 556,
        "y" : 189
      } ]
    } ],
    "outputs" : [ {
      "id" : 52464,
      "points" : [ {
        "x" : 650,
        "y" : 152
      } ]
    }, {
      "id" : 52465,
      "points" : [ {
        "x" : 648,
        "y" : 190
      } ]
    } ],
    "catalysts" : [ {
      "id" : 52460,
      "points" : [ {
        "x" : 625,
        "y" : 56
      } ]
    } ]
  }, {
    "id" : 52495,
    "reactomeId" : 10248669,
    "displayName" : "Exocytosis of Proactivator polypeptide",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 686,
      "y" : 554
    },
    "minX" : 606,
    "maxX" : 777,
    "minY" : 548,
    "maxY" : 560,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 606,
        "y" : 555
      },
      "to" : {
        "x" : 686,
        "y" : 554
      }
    }, {
      "from" : {
        "x" : 686,
        "y" : 554
      },
      "to" : {
        "x" : 777,
        "y" : 552
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 770,
        "y" : 556
      },
      "b" : {
        "x" : 777,
        "y" : 552
      },
      "c" : {
        "x" : 770,
        "y" : 548
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 770,
        "y" : 548
      }
    },
    "reactionShape" : {
      "a" : {
        "x" : 680,
        "y" : 548
      },
      "b" : {
        "x" : 692,
        "y" : 560
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 686,
        "y" : 554
      }
    },
    "inputs" : [ {
      "id" : 52496
    } ],
    "outputs" : [ {
      "id" : 52497
    } ]
  } ],
  "compartments" : [ {
    "id" : 52498,
    "reactomeId" : 70101,
    "displayName" : "cytosol",
    "schemaClass" : "Compartment",
    "renderableClass" : "Compartment",
    "position" : {
      "x" : 455,
      "y" : 399
    },
    "minX" : 147,
    "maxX" : 763,
    "minY" : 22,
    "maxY" : 776,
    "prop" : {
      "x" : 147,
      "y" : 22,
      "width" : 616,
      "height" : 754
    },
    "textPosition" : {
      "x" : 157,
      "y" : 49
    },
    "insets" : {
      "x" : 157,
      "y" : 32,
      "width" : 596,
      "height" : 734
    },
    "bgColor" : {
      "r" : 250,
      "g" : 240,
      "b" : 240
    },
    "componentIds" : [ 52455, 52459, 52460, 52457, 52456, 52464, 52461, 52463, 52499, 52500, 52482, 52486, 52467, 52458, 52489, 52501, 52503, 52490, 52465, 52466, 52468, 52504, 52483, 52477, 52495, 52492, 52480, 52462, 52474, 52472, 52471, 52470, 52475 ]
  }, {
    "id" : 52499,
    "reactomeId" : 114524,
    "displayName" : "platelet dense granule lumen",
    "schemaClass" : "Compartment",
    "renderableClass" : "Compartment",
    "position" : {
      "x" : 391,
      "y" : 410
    },
    "minX" : 241,
    "maxX" : 542,
    "minY" : 340,
    "maxY" : 481,
    "prop" : {
      "x" : 241,
      "y" : 340,
      "width" : 301,
      "height" : 141
    },
    "textPosition" : {
      "x" : 249,
      "y" : 343
    },
    "insets" : {
      "x" : 251,
      "y" : 350,
      "width" : 281,
      "height" : 121
    },
    "bgColor" : {
      "r" : 250,
      "g" : 240,
      "b" : 240
    },
    "componentIds" : [ 52469, 52481, 52478, 52476, 52473, 52506 ]
  }, {
    "id" : 52500,
    "reactomeId" : 114506,
    "displayName" : "platelet alpha granule lumen",
    "schemaClass" : "Compartment",
    "renderableClass" : "Compartment",
    "position" : {
      "x" : 346,
      "y" : 216
    },
    "minX" : 243,
    "maxX" : 450,
    "minY" : 116,
    "maxY" : 316,
    "prop" : {
      "x" : 243,
      "y" : 116,
      "width" : 207,
      "height" : 200
    },
    "textPosition" : {
      "x" : 249,
      "y" : 129
    },
    "insets" : {
      "x" : 253,
      "y" : 126,
      "width" : 187,
      "height" : 180
    },
    "bgColor" : {
      "r" : 250,
      "g" : 240,
      "b" : 240
    },
    "componentIds" : [ 52484, 52487 ]
  }, {
    "id" : 52501,
    "reactomeId" : 216798,
    "displayName" : "secretory granule",
    "schemaClass" : "GO_CellularComponent",
    "renderableClass" : "Compartment",
    "position" : {
      "x" : 286,
      "y" : 694
    },
    "minX" : 196,
    "maxX" : 376,
    "minY" : 633,
    "maxY" : 756,
    "prop" : {
      "x" : 196,
      "y" : 633,
      "width" : 180,
      "height" : 123
    },
    "textPosition" : {
      "x" : 203,
      "y" : 645
    },
    "insets" : {
      "x" : 206,
      "y" : 643,
      "width" : 160,
      "height" : 103
    },
    "bgColor" : {
      "r" : 250,
      "g" : 240,
      "b" : 240
    },
    "componentIds" : [ 52493 ]
  }, {
    "id" : 52503,
    "reactomeId" : 17957,
    "displayName" : "endoplasmic reticulum lumen",
    "schemaClass" : "Compartment",
    "renderableClass" : "Compartment",
    "position" : {
      "x" : 574,
      "y" : 665
    },
    "minX" : 477,
    "maxX" : 671,
    "minY" : 602,
    "maxY" : 728,
    "prop" : {
      "x" : 477,
      "y" : 602,
      "width" : 194,
      "height" : 126
    },
    "textPosition" : {
      "x" : 484,
      "y" : 605
    },
    "insets" : {
      "x" : 487,
      "y" : 612,
      "width" : 174,
      "height" : 106
    },
    "bgColor" : {
      "r" : 250,
      "g" : 240,
      "b" : 240
    }
  }, {
    "id" : 52504,
    "reactomeId" : 161320,
    "displayName" : "lysosomal lumen",
    "schemaClass" : "Compartment",
    "renderableClass" : "Compartment",
    "position" : {
      "x" : 567,
      "y" : 543
    },
    "minX" : 482,
    "maxX" : 652,
    "minY" : 499,
    "maxY" : 588,
    "prop" : {
      "x" : 482,
      "y" : 499,
      "width" : 170,
      "height" : 89
    },
    "textPosition" : {
      "x" : 489,
      "y" : 502
    },
    "insets" : {
      "x" : 492,
      "y" : 509,
      "width" : 150,
      "height" : 69
    },
    "bgColor" : {
      "r" : 250,
      "g" : 240,
      "b" : 240
    },
    "componentIds" : [ 52496 ]
  } ],
  "notes" : [ ],
  "links" : [ {
    "id" : 52505,
    "renderableClass" : "EntitySetAndEntitySetLink",
    "position" : {
      "x" : 106,
      "y" : 341
    },
    "minX" : 77,
    "maxX" : 135,
    "minY" : 242,
    "maxY" : 441,
    "segments" : [ {
      "from" : {
        "x" : 77,
        "y" : 242
      },
      "to" : {
        "x" : 135,
        "y" : 441
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 100,
        "y" : 335
      },
      "b" : {
        "x" : 112,
        "y" : 347
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 106,
        "y" : 341
      }
    },
    "inputs" : [ {
      "id" : 52488
    } ],
    "outputs" : [ {
      "id" : 52482
    } ]
  }, {
    "id" : 52506,
    "renderableClass" : "EntitySetAndMemberLink",
    "position" : {
      "x" : 416,
      "y" : 414
    },
    "minX" : 387,
    "maxX" : 446,
    "minY" : 406,
    "maxY" : 422,
    "segments" : [ {
      "from" : {
        "x" : 446,
        "y" : 422
      },
      "to" : {
        "x" : 387,
        "y" : 406
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 410,
        "y" : 408
      },
      "b" : {
        "x" : 422,
        "y" : 420
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 416,
        "y" : 414
      }
    },
    "inputs" : [ {
      "id" : 52473
    } ],
    "outputs" : [ {
      "id" : 52478
    } ]
  } ],
  "shadows" : [ {
    "id" : 52507,
    "reactomeId" : 10329135,
    "displayName" : "Disinhibition of SNARE formation",
    "schemaClass" : "Pathway",
    "renderableClass" : "Shadow",
    "position" : {
      "x" : 601,
      "y" : 151
    },
    "minX" : 486,
    "maxX" : 716,
    "minY" : -10,
    "maxY" : 313,
    "prop" : {
      "x" : 486,
      "y" : -10,
      "width" : 230,
      "height" : 158
    },
    "points" : [ {
      "x" : 486,
      "y" : -10
    }, {
      "x" : 716,
      "y" : -10
    }, {
      "x" : 716,
      "y" : 313
    }, {
      "x" : 486,
      "y" : 313
    } ],
    "colour" : "#4684ee"
  }, {
    "id" : 52508,
    "reactomeId" : 10330005,
    "displayName" : "Platelet degranulation ",
    "schemaClass" : "Pathway",
    "renderableClass" : "Shadow",
    "position" : {
      "x" : 430,
      "y" : 446
    },
    "minX" : -10,
    "maxX" : 871,
    "minY" : 148,
    "maxY" : 745,
    "prop" : {
      "x" : -10,
      "y" : 313,
      "width" : 881,
      "height" : 432
    },
    "points" : [ {
      "x" : -10,
      "y" : 148
    }, {
      "x" : 871,
      "y" : 148
    }, {
      "x" : 871,
      "y" : 745
    }, {
      "x" : -10,
      "y" : 745
    } ],
    "colour" : "#dc3912"
  } ],
  "minX" : 0,
  "maxX" : 861,
  "minY" : 0,
  "maxY" : 776,
  "disease" : false
}