{
  "dbId" : 10328927,
  "stId" : "R-CFA-2162123",
  "speciesName" : "Canis familiaris",
  "nodes" : [ {
    "dbId" : 879629,
    "stId" : "R-ALL-879629",
    "displayName" : "PGD2 [cytosol]",
    "schemaClass" : "SimpleEntity",
    "speciesId" : 0,
    "diagramIds" : [ 9989 ],
    "identifier" : "57406",
    "standardIdentifier" : "chebi:57406",
    "referenceType" : "ReferenceMolecule",
    "parents" : [ ],
    "children" : [ ]
  }, {
    "dbId" : 9677456,
    "stId" : "R-ALL-9677456",
    "displayName" : "suprofen [cytosol]",
    "schemaClass" : "ChemicalDrug",
    "speciesId" : 0,
    "identifier" : "7298",
    "standardIdentifier" : "iuphar.ligand:7298",
    "chebiIdentifier" : "chebi:9362",
    "parents" : [ 9716837 ],
    "children" : [ ]
  }, {
    "dbId" : 9677463,
    "stId" : "R-ALL-9677463",
    "displayName" : "ketoprofen [cytosol]",
    "schemaClass" : "ChemicalDrug",
    "speciesId" : 0,
    "identifier" : "4795",
    "standardIdentifier" : "iuphar.ligand:4795",
    "chebiIdentifier" : "chebi:6128",
    "parents" : [ 9716837 ],
    "children" : [ ]
  }, {
    "dbId" : 9677334,
    "stId" : "R-ALL-9677334",
    "displayName" : "nimesulide [cytosol]",
    "schemaClass" : "ChemicalDrug",
    "speciesId" : 0,
    "identifier" : "7401",
    "standardIdentifier" : "iuphar.ligand:7401",
    "chebiIdentifier" : "chebi:44445",
    "parents" : [ 9716837, 9677343 ],
    "children" : [ ]
  }, {
    "dbId" : 2239524,
    "stId" : "R-ALL-2239524",
    "displayName" : "GSH [endoplasmic reticulum membrane]",
    "schemaClass" : "SimpleEntity",
    "speciesId" : 0,
    "identifier" : "16856",
    "standardIdentifier" : "chebi:16856",
    "referenceType" : "ReferenceMolecule",
    "parents" : [ 10277213 ],
    "children" : [ ]
  }, {
    "dbId" : 9677460,
    "stId" : "R-ALL-9677460",
    "displayName" : "indomethacin [cytosol]",
    "schemaClass" : "ChemicalDrug",
    "speciesId" : 0,
    "identifier" : "1909",
    "standardIdentifier" : "iuphar.ligand:1909",
    "chebiIdentifier" : "chebi:49662",
    "parents" : [ 9677343 ],
    "children" : [ ]
  }, {
    "dbId" : 9915551,
    "stId" : "R-ALL-9915551",
    "displayName" : "hydrogen acceptor [endoplasmic reticulum lumen]",
    "schemaClass" : "SimpleEntity",
    "speciesId" : 0,
    "diagramIds" : [ 9968 ],
    "identifier" : "13193",
    "standardIdentifier" : "chebi:13193",
    "referenceType" : "ReferenceMolecule",
    "parents" : [ ],
    "children" : [ ]
  }, {
    "dbId" : 29450,
    "stId" : "R-ALL-29450",
    "displayName" : "GSH [cytosol]",
    "schemaClass" : "SimpleEntity",
    "speciesId" : 0,
    "identifier" : "57925",
    "standardIdentifier" : "chebi:57925",
    "referenceType" : "ReferenceMolecule",
    "parents" : [ 10277218 ],
    "children" : [ ]
  }, {
    "dbId" : 9677343,
    "stId" : "R-ALL-9677343",
    "displayName" : "PTGS1 Inhibitors [cytosol]",
    "schemaClass" : "DefinedSet",
    "speciesId" : 0,
    "diagramIds" : [ 10020 ],
    "parents" : [ 10320103 ],
    "children" : [ 9677640, 9677371, 9677460, 9677638, 9677334, 9677362 ]
  }, {
    "dbId" : 9677341,
    "stId" : "R-ALL-9677341",
    "displayName" : "ketorolac [cytosol]",
    "schemaClass" : "ChemicalDrug",
    "speciesId" : 0,
    "identifier" : "6661",
    "standardIdentifier" : "iuphar.ligand:6661",
    "chebiIdentifier" : "chebi:76223",
    "parents" : [ 9716837 ],
    "children" : [ ]
  }, {
    "dbId" : 2311355,
    "stId" : "R-ALL-2311355",
    "displayName" : "heme b [endoplasmic reticulum membrane]",
    "schemaClass" : "SimpleEntity",
    "speciesId" : 0,
    "identifier" : "26355",
    "standardIdentifier" : "chebi:26355",
    "referenceType" : "ReferenceMolecule",
    "parents" : [ 10278580, 10235244, 10278564, 10277306 ],
    "children" : [ ]
  }, {
    "dbId" : 10240188,
    "stId" : "R-CFA-2142706",
    "displayName" : "HPGDS [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 49646,
    "identifier" : "E5RQH2",
    "standardIdentifier" : "uniprot:E5RQH2",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "HPGDS" ],
    "parents" : [ 10277218 ],
    "children" : [ ]
  }, {
    "dbId" : 9677362,
    "stId" : "R-ALL-9677362",
    "displayName" : "APAP [cytosol]",
    "schemaClass" : "ChemicalDrug",
    "speciesId" : 0,
    "identifier" : "5239",
    "standardIdentifier" : "iuphar.ligand:5239",
    "chebiIdentifier" : "chebi:46195",
    "parents" : [ 9716837, 9677343 ],
    "children" : [ ]
  }, {
    "dbId" : 879535,
    "stId" : "R-ALL-879535",
    "displayName" : "PGF2a [cytosol]",
    "schemaClass" : "SimpleEntity",
    "speciesId" : 0,
    "diagramIds" : [ 9974 ],
    "identifier" : "57404",
    "standardIdentifier" : "chebi:57404",
    "referenceType" : "ReferenceMolecule",
    "parents" : [ ],
    "children" : [ ]
  }, {
    "dbId" : 10277304,
    "stId" : "R-CFA-61605",
    "displayName" : "PTGS2 [endoplasmic reticulum membrane]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 49646,
    "identifier" : "Q8SPQ9",
    "standardIdentifier" : "uniprot:Q8SPQ9",
    "referenceType" : "ReferenceGeneProduct",
    "parents" : [ 10278564, 10277306 ],
    "children" : [ ]
  }, {
    "dbId" : 10277306,
    "stId" : "R-CFA-2314687",
    "displayName" : "Ac-PTGS2 dimer [endoplasmic reticulum membrane]",
    "schemaClass" : "Complex",
    "speciesId" : 49646,
    "diagramIds" : [ 10018 ],
    "parents" : [ ],
    "children" : [ 10277302, 2311355, 10277304 ]
  }, {
    "dbId" : 10278580,
    "stId" : "R-CFA-2314695",
    "displayName" : "Ac-PTGS1 dimer [endoplasmic reticulum membrane]",
    "schemaClass" : "Complex",
    "speciesId" : 49646,
    "diagramIds" : [ 10015 ],
    "parents" : [ ],
    "children" : [ 10278578, 2311355, 10235242 ]
  }, {
    "dbId" : 9677371,
    "stId" : "R-ALL-9677371",
    "displayName" : "meloxicam [cytosol]",
    "schemaClass" : "ChemicalDrug",
    "speciesId" : 0,
    "identifier" : "7220",
    "standardIdentifier" : "iuphar.ligand:7220",
    "chebiIdentifier" : "chebi:6741",
    "parents" : [ 9677343 ],
    "children" : [ ]
  }, {
    "dbId" : 10277302,
    "stId" : "R-CFA-2161824",
    "displayName" : "O-acetyl-L-serine-PTGS2 [endoplasmic reticulum membrane]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 49646,
    "identifier" : "Q8SPQ9",
    "standardIdentifier" : "uniprot:Q8SPQ9",
    "referenceType" : "ReferenceGeneProduct",
    "parents" : [ 10277306 ],
    "children" : [ ]
  }, {
    "dbId" : 549282,
    "stId" : "R-ALL-549282",
    "displayName" : "MNA [cytosol]",
    "schemaClass" : "SimpleEntity",
    "speciesId" : 0,
    "diagramIds" : [ 10011 ],
    "identifier" : "16797",
    "standardIdentifier" : "chebi:16797",
    "referenceType" : "ReferenceMolecule",
    "parents" : [ ],
    "children" : [ ]
  }, {
    "dbId" : 9677375,
    "stId" : "R-ALL-9677375",
    "displayName" : "ibuprofen [cytosol]",
    "schemaClass" : "ChemicalDrug",
    "speciesId" : 0,
    "identifier" : "2713",
    "standardIdentifier" : "iuphar.ligand:2713",
    "chebiIdentifier" : "chebi:5855",
    "parents" : [ 9716837 ],
    "children" : [ ]
  }, {
    "dbId" : 9677630,
    "stId" : "R-ALL-9677630",
    "displayName" : "phenylbutazone [cytosol]",
    "schemaClass" : "ChemicalDrug",
    "speciesId" : 0,
    "identifier" : "7270",
    "standardIdentifier" : "iuphar.ligand:7270",
    "chebiIdentifier" : "chebi:48574",
    "parents" : [ 9716837 ],
    "children" : [ ]
  }, {
    "dbId" : 10278578,
    "stId" : "R-CFA-2314694",
    "displayName" : "O-acetyl-L-serine-PTGS1 [endoplasmic reticulum membrane]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 49646,
    "identifier" : "Q8HZR1",
    "standardIdentifier" : "uniprot:Q8HZR1",
    "referenceType" : "ReferenceGeneProduct",
    "parents" : [ 10278580 ],
    "children" : [ ]
  }, {
    "dbId" : 9915557,
    "stId" : "R-ALL-9915557",
    "displayName" : "hydrogen donor [endoplasmic reticulum lumen]",
    "schemaClass" : "SimpleEntity",
    "speciesId" : 0,
    "diagramIds" : [ 9965 ],
    "identifier" : "17499",
    "standardIdentifier" : "chebi:17499",
    "referenceType" : "ReferenceMolecule",
    "parents" : [ ],
    "children" : [ ]
  }, {
    "dbId" : 10242222,
    "stId" : "R-CFA-192142",
    "displayName" : "AKR1C3 [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 49646,
    "diagramIds" : [ 9975, 9996 ],
    "identifier" : "A0A8I3MRB2",
    "standardIdentifier" : "uniprot:A0A8I3MRB2",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "AKR1C3" ],
    "parents" : [ ],
    "children" : [ ]
  }, {
    "dbId" : 29364,
    "stId" : "R-ALL-29364",
    "displayName" : "NADPH [cytosol]",
    "schemaClass" : "SimpleEntity",
    "speciesId" : 0,
    "diagramIds" : [ 9972, 9992, 9981 ],
    "identifier" : "57783",
    "standardIdentifier" : "chebi:57783",
    "referenceType" : "ReferenceMolecule",
    "parents" : [ ],
    "children" : [ ]
  }, {
    "dbId" : 9677477,
    "stId" : "R-ALL-9677477",
    "displayName" : "piroxicam [cytosol]",
    "schemaClass" : "ChemicalDrug",
    "speciesId" : 0,
    "identifier" : "7273",
    "standardIdentifier" : "iuphar.ligand:7273",
    "chebiIdentifier" : "chebi:8249",
    "parents" : [ 9716837 ],
    "children" : [ ]
  }, {
    "dbId" : 29366,
    "stId" : "R-ALL-29366",
    "displayName" : "NADP+ [cytosol]",
    "schemaClass" : "SimpleEntity",
    "speciesId" : 0,
    "diagramIds" : [ 9973, 9995, 9983 ],
    "identifier" : "58349",
    "standardIdentifier" : "chebi:58349",
    "referenceType" : "ReferenceMolecule",
    "parents" : [ ],
    "children" : [ ]
  }, {
    "dbId" : 10278564,
    "stId" : "R-CFA-140491",
    "displayName" : "PTGS2 dimer [endoplasmic reticulum membrane]",
    "schemaClass" : "Complex",
    "speciesId" : 49646,
    "diagramIds" : [ 10009 ],
    "parents" : [ 10321649, 10278567 ],
    "children" : [ 2311355, 10277304 ]
  }, {
    "dbId" : 9677482,
    "stId" : "R-ALL-9677482",
    "displayName" : "naproxen [cytosol]",
    "schemaClass" : "ChemicalDrug",
    "speciesId" : 0,
    "identifier" : "5230",
    "standardIdentifier" : "iuphar.ligand:5230",
    "chebiIdentifier" : "chebi:7476",
    "parents" : [ 9716837 ],
    "children" : [ ]
  }, {
    "dbId" : 30138,
    "stId" : "R-ALL-30138",
    "displayName" : "PGH2 [endoplasmic reticulum lumen]",
    "schemaClass" : "SimpleEntity",
    "speciesId" : 0,
    "diagramIds" : [ 9967 ],
    "identifier" : "57405",
    "standardIdentifier" : "chebi:57405",
    "referenceType" : "ReferenceMolecule",
    "parents" : [ ],
    "children" : [ ]
  }, {
    "dbId" : 9677353,
    "stId" : "R-ALL-9677353",
    "displayName" : "meclofenamic acid [cytosol]",
    "schemaClass" : "ChemicalDrug",
    "speciesId" : 0,
    "identifier" : "7219",
    "standardIdentifier" : "iuphar.ligand:7219",
    "chebiIdentifier" : "chebi:6710",
    "parents" : [ 9716837 ],
    "children" : [ ]
  }, {
    "dbId" : 2161562,
    "stId" : "R-ALL-2161562",
    "displayName" : "MDA [endoplasmic reticulum lumen]",
    "schemaClass" : "SimpleEntity",
    "speciesId" : 0,
    "diagramIds" : [ 10004 ],
    "identifier" : "566274",
    "standardIdentifier" : "chebi:566274",
    "referenceType" : "ReferenceMolecule",
    "parents" : [ ],
    "children" : [ ]
  }, {
    "dbId" : 10278567,
    "stId" : "R-CFA-2309778",
    "displayName" : "PTGS2 dimer:PTGS2 inhibitors [endoplasmic reticulum membrane]",
    "schemaClass" : "Complex",
    "speciesId" : 49646,
    "diagramIds" : [ 10012 ],
    "parents" : [ ],
    "children" : [ 9716714, 10278564 ]
  }, {
    "dbId" : 9677357,
    "stId" : "R-ALL-9677357",
    "displayName" : "flurbiprofen [cytosol]",
    "schemaClass" : "ChemicalDrug",
    "speciesId" : 0,
    "identifier" : "4194",
    "standardIdentifier" : "iuphar.ligand:4194",
    "chebiIdentifier" : "chebi:5130",
    "parents" : [ 9716837 ],
    "children" : [ ]
  }, {
    "dbId" : 10232413,
    "stId" : "R-CFA-65976",
    "displayName" : "TBXAS1 [endoplasmic reticulum membrane]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 49646,
    "diagramIds" : [ 10002 ],
    "identifier" : "A0A8I3Q8L4",
    "standardIdentifier" : "uniprot:A0A8I3Q8L4",
    "referenceType" : "ReferenceGeneProduct",
    "parents" : [ ],
    "children" : [ ]
  }, {
    "dbId" : 10277213,
    "stId" : "R-CFA-2142686",
    "displayName" : "PTGES trimer [endoplasmic reticulum membrane]",
    "schemaClass" : "Complex",
    "speciesId" : 49646,
    "diagramIds" : [ 9978 ],
    "parents" : [ ],
    "children" : [ 10277211, 2239524 ]
  }, {
    "dbId" : 2161634,
    "stId" : "R-ALL-2161634",
    "displayName" : "PGD2 [endoplasmic reticulum lumen]",
    "schemaClass" : "SimpleEntity",
    "speciesId" : 0,
    "diagramIds" : [ 9986 ],
    "identifier" : "57406",
    "standardIdentifier" : "chebi:57406",
    "referenceType" : "ReferenceMolecule",
    "parents" : [ ],
    "children" : [ ]
  }, {
    "dbId" : 265287,
    "stId" : "R-ALL-265287",
    "displayName" : "PGE2 [cytosol]",
    "schemaClass" : "SimpleEntity",
    "speciesId" : 0,
    "diagramIds" : [ 9977, 9980 ],
    "identifier" : "606564",
    "standardIdentifier" : "chebi:606564",
    "referenceType" : "ReferenceMolecule",
    "parents" : [ ],
    "children" : [ ]
  }, {
    "dbId" : 140356,
    "stId" : "R-ALL-140356",
    "displayName" : "AA [endoplasmic reticulum lumen]",
    "schemaClass" : "SimpleEntity",
    "speciesId" : 0,
    "diagramIds" : [ 9961 ],
    "identifier" : "32395",
    "standardIdentifier" : "chebi:32395",
    "referenceType" : "ReferenceMolecule",
    "parents" : [ ],
    "children" : [ ]
  }, {
    "dbId" : 265283,
    "stId" : "R-ALL-265283",
    "displayName" : "PGH2 [cytosol]",
    "schemaClass" : "SimpleEntity",
    "speciesId" : 0,
    "diagramIds" : [ 9970 ],
    "identifier" : "57405",
    "standardIdentifier" : "chebi:57405",
    "referenceType" : "ReferenceMolecule",
    "parents" : [ ],
    "children" : [ ]
  }, {
    "dbId" : 140357,
    "stId" : "R-ALL-140357",
    "displayName" : "PGG2 [endoplasmic reticulum lumen]",
    "schemaClass" : "SimpleEntity",
    "speciesId" : 0,
    "diagramIds" : [ 9962 ],
    "identifier" : "82629",
    "standardIdentifier" : "chebi:82629",
    "referenceType" : "ReferenceMolecule",
    "parents" : [ ],
    "children" : [ ]
  }, {
    "dbId" : 10277211,
    "stId" : "R-CFA-2142717",
    "displayName" : "PTGES [endoplasmic reticulum membrane]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 49646,
    "identifier" : "A0SYQ0",
    "standardIdentifier" : "uniprot:A0SYQ0",
    "referenceType" : "ReferenceGeneProduct",
    "parents" : [ 10277213 ],
    "children" : [ ]
  }, {
    "dbId" : 10232404,
    "stId" : "R-CFA-192012",
    "displayName" : "CYP8B1 [endoplasmic reticulum membrane]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 49646,
    "identifier" : "A0A8I3PFY5",
    "standardIdentifier" : "uniprot:A0A8I3PFY5",
    "referenceType" : "ReferenceGeneProduct",
    "parents" : [ 10232406 ],
    "children" : [ ]
  }, {
    "dbId" : 10277204,
    "stId" : "R-CFA-2142784",
    "displayName" : "CBR1 [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 49646,
    "diagramIds" : [ 9984 ],
    "identifier" : "A0A8I3PV18",
    "standardIdentifier" : "uniprot:A0A8I3PV18",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "CBR1" ],
    "parents" : [ ],
    "children" : [ ]
  }, {
    "dbId" : 9677402,
    "stId" : "R-ALL-9677402",
    "displayName" : "oxaprozin [cytosol]",
    "schemaClass" : "ChemicalDrug",
    "speciesId" : 0,
    "identifier" : "7252",
    "standardIdentifier" : "iuphar.ligand:7252",
    "chebiIdentifier" : "chebi:7822",
    "parents" : [ 9716837 ],
    "children" : [ ]
  }, {
    "dbId" : 10232406,
    "stId" : "R-CFA-3222410",
    "displayName" : "PTGIS,CYP8B1 [endoplasmic reticulum membrane]",
    "schemaClass" : "CandidateSet",
    "speciesId" : 49646,
    "diagramIds" : [ 9999 ],
    "parents" : [ ],
    "children" : [ 10232400, 10232404 ]
  }, {
    "dbId" : 10232400,
    "stId" : "R-CFA-62410",
    "displayName" : "PTGIS [endoplasmic reticulum membrane]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 49646,
    "identifier" : "A0A8I3PJM8",
    "standardIdentifier" : "uniprot:A0A8I3PJM8",
    "referenceType" : "ReferenceGeneProduct",
    "parents" : [ 10232406 ],
    "children" : [ ]
  }, {
    "dbId" : 9677404,
    "stId" : "R-ALL-9677404",
    "displayName" : "mefenamic acid [cytosol]",
    "schemaClass" : "ChemicalDrug",
    "speciesId" : 0,
    "identifier" : "2593",
    "standardIdentifier" : "iuphar.ligand:2593",
    "chebiIdentifier" : "chebi:6717",
    "parents" : [ 9716837 ],
    "children" : [ ]
  }, {
    "dbId" : 10277197,
    "stId" : "R-CFA-2142814",
    "displayName" : "PTGDS [endoplasmic reticulum membrane]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 49646,
    "diagramIds" : [ 9987 ],
    "identifier" : "Q9XS65",
    "standardIdentifier" : "uniprot:Q9XS65",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "PTGDS" ],
    "parents" : [ ],
    "children" : [ ]
  }, {
    "dbId" : 9677638,
    "stId" : "R-ALL-9677638",
    "displayName" : "fenoprofen [cytosol]",
    "schemaClass" : "ChemicalDrug",
    "speciesId" : 0,
    "identifier" : "4820",
    "standardIdentifier" : "iuphar.ligand:4820",
    "chebiIdentifier" : "chebi:5004",
    "parents" : [ 9677343 ],
    "children" : [ ]
  }, {
    "dbId" : 2142710,
    "stId" : "R-ALL-2142710",
    "displayName" : "11epi-PGF2a [cytosol]",
    "schemaClass" : "SimpleEntity",
    "speciesId" : 0,
    "diagramIds" : [ 9994 ],
    "identifier" : "85173",
    "standardIdentifier" : "chebi:85173",
    "referenceType" : "ReferenceMolecule",
    "parents" : [ ],
    "children" : [ ]
  }, {
    "dbId" : 70106,
    "stId" : "R-ALL-70106",
    "displayName" : "H+ [cytosol]",
    "schemaClass" : "SimpleEntity",
    "speciesId" : 0,
    "diagramIds" : [ 9971, 9993, 9982 ],
    "identifier" : "15378",
    "standardIdentifier" : "chebi:15378",
    "referenceType" : "ReferenceMolecule",
    "parents" : [ ],
    "children" : [ ]
  }, {
    "dbId" : 9677640,
    "stId" : "R-ALL-9677640",
    "displayName" : "bromfenac [cytosol]",
    "schemaClass" : "ChemicalDrug",
    "speciesId" : 0,
    "identifier" : "7131",
    "standardIdentifier" : "iuphar.ligand:7131",
    "chebiIdentifier" : "chebi:240107",
    "parents" : [ 9677343 ],
    "children" : [ ]
  }, {
    "dbId" : 2314690,
    "stId" : "R-ALL-2314690",
    "displayName" : "ST [cytosol]",
    "schemaClass" : "SimpleEntity",
    "speciesId" : 0,
    "diagramIds" : [ 10016 ],
    "identifier" : "30762",
    "standardIdentifier" : "chebi:30762",
    "referenceType" : "ReferenceMolecule",
    "parents" : [ ],
    "children" : [ ]
  }, {
    "dbId" : 9716725,
    "stId" : "R-ALL-9716725",
    "displayName" : "etodolac [cytosol]",
    "schemaClass" : "ChemicalDrug",
    "speciesId" : 0,
    "identifier" : "7185",
    "standardIdentifier" : "iuphar.ligand:7185",
    "chebiIdentifier" : "chebi:4909",
    "parents" : [ 9716714 ],
    "children" : [ ]
  }, {
    "dbId" : 2314693,
    "stId" : "R-ALL-2314693",
    "displayName" : "ASA- [cytosol]",
    "schemaClass" : "ChemicalDrug",
    "speciesId" : 0,
    "diagramIds" : [ 10014 ],
    "identifier" : "4139",
    "standardIdentifier" : "iuphar.ligand:4139",
    "chebiIdentifier" : "chebi:15365",
    "parents" : [ ],
    "children" : [ ]
  }, {
    "dbId" : 9716723,
    "stId" : "R-ALL-9716723",
    "displayName" : "celecoxib [cytosol]",
    "schemaClass" : "ChemicalDrug",
    "speciesId" : 0,
    "identifier" : "2892",
    "standardIdentifier" : "iuphar.ligand:2892",
    "chebiIdentifier" : "chebi:41423",
    "parents" : [ 9716714 ],
    "children" : [ ]
  }, {
    "dbId" : 10321653,
    "stId" : "R-CFA-9716834",
    "displayName" : "PTGS1 dimer:PTGS Inhibitors [endoplasmic reticulum membrane]",
    "schemaClass" : "Complex",
    "speciesId" : 49646,
    "diagramIds" : [ 10027 ],
    "parents" : [ ],
    "children" : [ 9716837, 10235244 ]
  }, {
    "dbId" : 9716732,
    "stId" : "R-ALL-9716732",
    "displayName" : "etoricoxib [cytosol]",
    "schemaClass" : "ChemicalDrug",
    "speciesId" : 0,
    "identifier" : "2896",
    "standardIdentifier" : "iuphar.ligand:2896",
    "chebiIdentifier" : "chebi:6339",
    "parents" : [ 9716714 ],
    "children" : [ ]
  }, {
    "dbId" : 31593,
    "stId" : "R-ALL-31593",
    "displayName" : "PGI2 [endoplasmic reticulum lumen]",
    "schemaClass" : "SimpleEntity",
    "speciesId" : 0,
    "diagramIds" : [ 9998 ],
    "identifier" : "57403",
    "standardIdentifier" : "chebi:57403",
    "referenceType" : "ReferenceMolecule",
    "parents" : [ ],
    "children" : [ ]
  }, {
    "dbId" : 9716734,
    "stId" : "R-ALL-9716734",
    "displayName" : "benzquinamide [cytosol]",
    "schemaClass" : "ChemicalDrug",
    "speciesId" : 0,
    "identifier" : "7124",
    "standardIdentifier" : "iuphar.ligand:7124",
    "chebiIdentifier" : "chebi:27662",
    "parents" : [ 9716714 ],
    "children" : [ ]
  }, {
    "dbId" : 10321649,
    "stId" : "R-CFA-9716835",
    "displayName" : "PTGS2 dimer:PTGS inhibitors [endoplasmic reticulum membrane]",
    "schemaClass" : "Complex",
    "speciesId" : 49646,
    "diagramIds" : [ 10026 ],
    "parents" : [ ],
    "children" : [ 10278564, 9716837 ]
  }, {
    "dbId" : 9716728,
    "stId" : "R-ALL-9716728",
    "displayName" : "carprofen [cytosol]",
    "schemaClass" : "ChemicalDrug",
    "speciesId" : 0,
    "identifier" : "7141",
    "standardIdentifier" : "iuphar.ligand:7141",
    "chebiIdentifier" : "chebi:364453",
    "parents" : [ 9716714 ],
    "children" : [ ]
  }, {
    "dbId" : 9677438,
    "stId" : "R-ALL-9677438",
    "displayName" : "diclofenac [cytosol]",
    "schemaClass" : "ChemicalDrug",
    "speciesId" : 0,
    "identifier" : "2714",
    "standardIdentifier" : "iuphar.ligand:2714",
    "chebiIdentifier" : "chebi:47381",
    "parents" : [ 9716837 ],
    "children" : [ ]
  }, {
    "dbId" : 2142797,
    "stId" : "R-ALL-2142797",
    "displayName" : "12S-HHT [endoplasmic reticulum lumen]",
    "schemaClass" : "SimpleEntity",
    "speciesId" : 0,
    "diagramIds" : [ 10005 ],
    "identifier" : "90694",
    "standardIdentifier" : "chebi:90694",
    "referenceType" : "ReferenceMolecule",
    "parents" : [ ],
    "children" : [ ]
  }, {
    "dbId" : 10248178,
    "stId" : "R-CFA-5423596",
    "displayName" : "PTGES2 [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 49646,
    "diagramIds" : [ 10007 ],
    "identifier" : "B4YY03",
    "standardIdentifier" : "uniprot:B4YY03",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "PTGES2" ],
    "parents" : [ ],
    "children" : [ ]
  }, {
    "dbId" : 113519,
    "stId" : "R-ALL-113519",
    "displayName" : "H2O [endoplasmic reticulum lumen]",
    "schemaClass" : "SimpleEntity",
    "speciesId" : 0,
    "diagramIds" : [ 9966 ],
    "identifier" : "15377",
    "standardIdentifier" : "chebi:15377",
    "referenceType" : "ReferenceMolecule",
    "parents" : [ ],
    "children" : [ ]
  }, {
    "dbId" : 9716731,
    "stId" : "R-ALL-9716731",
    "displayName" : "lumiracoxib [cytosol]",
    "schemaClass" : "ChemicalDrug",
    "speciesId" : 0,
    "identifier" : "2897",
    "standardIdentifier" : "iuphar.ligand:2897",
    "chebiIdentifier" : "chebi:73044",
    "parents" : [ 9716714 ],
    "children" : [ ]
  }, {
    "dbId" : 32879,
    "stId" : "R-ALL-32879",
    "displayName" : "TXA2 [endoplasmic reticulum lumen]",
    "schemaClass" : "SimpleEntity",
    "speciesId" : 0,
    "diagramIds" : [ 10001 ],
    "identifier" : "57445",
    "standardIdentifier" : "chebi:57445",
    "referenceType" : "ReferenceMolecule",
    "parents" : [ ],
    "children" : [ ]
  }, {
    "dbId" : 10235244,
    "stId" : "R-CFA-428986",
    "displayName" : "PTGS1 dimer [endoplasmic reticulum membrane]",
    "schemaClass" : "Complex",
    "speciesId" : 49646,
    "diagramIds" : [ 9963 ],
    "parents" : [ 10321653, 10320103 ],
    "children" : [ 2311355, 10235242 ]
  }, {
    "dbId" : 9716837,
    "stId" : "R-ALL-9716837",
    "displayName" : "PTGS inhibitors [cytosol]",
    "schemaClass" : "DefinedSet",
    "speciesId" : 0,
    "diagramIds" : [ 10025 ],
    "parents" : [ 10321649, 10321653 ],
    "children" : [ 9677362, 9677456, 9677463, 9677334, 9677402, 9677375, 9677438, 9677630, 9677341, 9677404, 9677477, 9677482, 9677353, 9677357 ]
  }, {
    "dbId" : 10235242,
    "stId" : "R-CFA-428931",
    "displayName" : "PTGS1 [endoplasmic reticulum membrane]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 49646,
    "identifier" : "Q8HZR1",
    "standardIdentifier" : "uniprot:Q8HZR1",
    "referenceType" : "ReferenceGeneProduct",
    "parents" : [ 10278580, 10235244 ],
    "children" : [ ]
  }, {
    "dbId" : 9716716,
    "stId" : "R-ALL-9716716",
    "displayName" : "rofecoxib [cytosol]",
    "schemaClass" : "ChemicalDrug",
    "speciesId" : 0,
    "identifier" : "2893",
    "standardIdentifier" : "iuphar.ligand:2893",
    "chebiIdentifier" : "chebi:8887",
    "parents" : [ 9716714 ],
    "children" : [ ]
  }, {
    "dbId" : 10331879,
    "stId" : "R-CFA-9749641",
    "displayName" : "Aspirin ADME",
    "schemaClass" : "Pathway",
    "speciesId" : 49646,
    "diagramIds" : [ 10060 ]
  }, {
    "dbId" : 10320103,
    "stId" : "R-CFA-9677354",
    "displayName" : "PTGS1 dimer:PTGS1 Inhibitors [endoplasmic reticulum membrane]",
    "schemaClass" : "Complex",
    "speciesId" : 49646,
    "diagramIds" : [ 10021 ],
    "parents" : [ ],
    "children" : [ 9677343, 10235244 ]
  }, {
    "dbId" : 9716713,
    "stId" : "R-ALL-9716713",
    "displayName" : "valdecoxib [cytosol]",
    "schemaClass" : "ChemicalDrug",
    "speciesId" : 0,
    "identifier" : "2894",
    "standardIdentifier" : "iuphar.ligand:2894",
    "chebiIdentifier" : "chebi:63634",
    "parents" : [ 9716714 ],
    "children" : [ ]
  }, {
    "dbId" : 9716714,
    "stId" : "R-ALL-9716714",
    "displayName" : "PTGS2 inhibitors [cytosol]",
    "schemaClass" : "DefinedSet",
    "speciesId" : 0,
    "diagramIds" : [ 10023 ],
    "parents" : [ 10278567 ],
    "children" : [ 9716731, 9716713, 9716728, 9716734, 9716716, 9716732, 9716723, 9716725 ]
  }, {
    "dbId" : 10277218,
    "stId" : "R-CFA-2142683",
    "displayName" : "HPGDS dimer [cytosol]",
    "schemaClass" : "Complex",
    "speciesId" : 49646,
    "diagramIds" : [ 9990 ],
    "parents" : [ ],
    "children" : [ 29450, 10240188 ]
  }, {
    "dbId" : 113534,
    "stId" : "R-ALL-113534",
    "displayName" : "O2 [endoplasmic reticulum lumen]",
    "schemaClass" : "SimpleEntity",
    "speciesId" : 0,
    "diagramIds" : [ 9960 ],
    "identifier" : "15379",
    "standardIdentifier" : "chebi:15379",
    "referenceType" : "ReferenceMolecule",
    "parents" : [ ],
    "children" : [ ]
  } ],
  "edges" : [ {
    "dbId" : 10278584,
    "stId" : "R-CFA-2314686",
    "displayName" : "ASA- acetylates PTGS2",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "inputs" : [ 10278564, 2314693 ],
    "outputs" : [ 10277306, 2314690 ],
    "efs" : [ ],
    "diagramIds" : [ 10017 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10232409,
    "stId" : "R-CFA-76496",
    "displayName" : "PTGIS, CYP8A1 isomerise PGH2 to PGI2",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "preceding" : [ 10235250, 10278569 ],
    "inputs" : [ 30138 ],
    "outputs" : [ 31593 ],
    "catalysts" : [ 10232406 ],
    "efs" : [ ],
    "diagramIds" : [ 9997 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10248181,
    "stId" : "R-CFA-265295",
    "displayName" : "Prostaglandin E synthase isomerizes PGH2 to PGE2",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "inputs" : [ 265283 ],
    "outputs" : [ 265287 ],
    "catalysts" : [ 10248178 ],
    "efs" : [ ],
    "diagramIds" : [ 10006 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10278582,
    "stId" : "R-CFA-2314678",
    "displayName" : "ASA- acetylates PTGS1",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "inputs" : [ 2314693, 10235244 ],
    "outputs" : [ 10278580, 2314690 ],
    "efs" : [ ],
    "diagramIds" : [ 10013 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10321655,
    "stId" : "R-CFA-9716838",
    "displayName" : "PTGS1,2 dimers bind PTGS Inhibitors",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "inputs" : [ 10278564, 9716837, 10235244 ],
    "outputs" : [ 10321649, 10321653 ],
    "efs" : [ ],
    "diagramIds" : [ 10024 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10277207,
    "stId" : "R-CFA-2161651",
    "displayName" : "PGE2 is converted to PGF2a by CBR1",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "inputs" : [ 70106, 29364, 265287 ],
    "outputs" : [ 29366, 879535 ],
    "catalysts" : [ 10277204 ],
    "efs" : [ ],
    "diagramIds" : [ 9979 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10277200,
    "stId" : "R-CFA-2161620",
    "displayName" : "PGH2 is isomerised to PGD2 by PTGDS",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "preceding" : [ 10235250, 10278569 ],
    "inputs" : [ 30138 ],
    "outputs" : [ 2161634 ],
    "catalysts" : [ 10277197 ],
    "efs" : [ ],
    "diagramIds" : [ 9985 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10321651,
    "stId" : "R-CFA-9716836",
    "displayName" : "PTGS2 dimer binds PTGS inhibitors",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "inputs" : [ 10278564, 9716837 ],
    "outputs" : [ 10321649 ],
    "efs" : [ ],
    "diagramIds" : [ 10028 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10235250,
    "stId" : "R-CFA-140359",
    "displayName" : "PGG2 is reduced to PGH2 by PTGS1",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "preceding" : [ 10235247 ],
    "following" : [ 10277190, 10277200, 10232416, 10232409 ],
    "inputs" : [ 140357, 9915557 ],
    "outputs" : [ 113519, 30138, 9915551 ],
    "catalysts" : [ 10235244 ],
    "efs" : [ ],
    "diagramIds" : [ 9964 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10278572,
    "stId" : "R-CFA-2309779",
    "displayName" : "PTGS2 dimer binds PTGS2 inhibitors",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "inputs" : [ 9716714, 10278564 ],
    "outputs" : [ 10278567 ],
    "efs" : [ ],
    "diagramIds" : [ 10022 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10235247,
    "stId" : "R-CFA-140355",
    "displayName" : "Arachidonate is oxidised to PGG2 by PTGS1",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "following" : [ 10235250 ],
    "inputs" : [ 113534, 140356 ],
    "outputs" : [ 140357 ],
    "catalysts" : [ 10235244 ],
    "efs" : [ ],
    "diagramIds" : [ 9959 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10278575,
    "stId" : "R-CFA-2309787",
    "displayName" : "Arachidonate is oxidised to PGG2 by PTGS2",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "following" : [ 10278569 ],
    "inputs" : [ 113534, 140356 ],
    "outputs" : [ 140357 ],
    "catalysts" : [ 10278564 ],
    "efs" : [ ],
    "diagramIds" : [ 10008 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10320105,
    "stId" : "R-CFA-9677320",
    "displayName" : "PTGS1 dimer binds PTGS1 Inhibitors",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "inputs" : [ 9677343, 10235244 ],
    "outputs" : [ 10320103 ],
    "efs" : [ ],
    "diagramIds" : [ 10019 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10278569,
    "stId" : "R-CFA-2309773",
    "displayName" : "PGG2 is reduced to PGH2 by PTGS2",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "preceding" : [ 10278575 ],
    "following" : [ 10277190, 10277200, 10232416, 10232409 ],
    "inputs" : [ 140357, 9915557 ],
    "outputs" : [ 113519, 30138, 9915551 ],
    "catalysts" : [ 10278564 ],
    "efs" : [ ],
    "inhibitors" : [ 10278567 ],
    "activators" : [ 549282 ],
    "diagramIds" : [ 10010 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10277193,
    "stId" : "R-CFA-2161614",
    "displayName" : "PGD2 is reduced to 11-epi-PGF2a by AKRIC3",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "preceding" : [ 10277221 ],
    "inputs" : [ 70106, 29364, 879629 ],
    "outputs" : [ 29366, 2142710 ],
    "catalysts" : [ 10242222 ],
    "efs" : [ ],
    "diagramIds" : [ 9991 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10277221,
    "stId" : "R-CFA-2161701",
    "displayName" : "PGH2 is isomerised to PGD2 by HPGDS",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "following" : [ 10277193 ],
    "inputs" : [ 265283 ],
    "outputs" : [ 879629 ],
    "catalysts" : [ 10277218 ],
    "efs" : [ ],
    "diagramIds" : [ 9988 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10277190,
    "stId" : "R-CFA-2161613",
    "displayName" : "PGH2 is degraded to 12S-HHT and MDA by TBXAS1",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "preceding" : [ 10235250, 10278569 ],
    "inputs" : [ 30138 ],
    "outputs" : [ 2142797, 2161562 ],
    "catalysts" : [ 10232413 ],
    "efs" : [ ],
    "diagramIds" : [ 10003 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10277216,
    "stId" : "R-CFA-2161660",
    "displayName" : "PGH2 is isomerised to PGE2 by PTGES",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "inputs" : [ 265283 ],
    "outputs" : [ 265287 ],
    "catalysts" : [ 10277213 ],
    "efs" : [ ],
    "diagramIds" : [ 9976 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10232416,
    "stId" : "R-CFA-76500",
    "displayName" : "TBXAS1 isomerises PGH2 to TXA2",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "preceding" : [ 10235250, 10278569 ],
    "inputs" : [ 30138 ],
    "outputs" : [ 32879 ],
    "catalysts" : [ 10232413 ],
    "efs" : [ ],
    "diagramIds" : [ 10000 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10277187,
    "stId" : "R-CFA-2161549",
    "displayName" : "PGH2 is reduced to PGF2a by AKR1C3",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "inputs" : [ 70106, 265283, 29364 ],
    "outputs" : [ 29366, 879535 ],
    "catalysts" : [ 10242222 ],
    "efs" : [ ],
    "diagramIds" : [ 9969 ],
    "entityFunctionalStatus" : [ ]
  } ]
}