{
  "dbId" : 10328691,
  "stableId" : "R-CFA-75157",
  "displayName" : "FasL/ CD95L signaling",
  "nodes" : [ {
    "id" : 97248,
    "reactomeId" : 10328795,
    "displayName" : "Caspase activation via Death Receptors in the presence of ligand",
    "schemaClass" : "Pathway",
    "renderableClass" : "EncapsulatedNode",
    "position" : {
      "x" : 880,
      "y" : 367
    },
    "minX" : 813,
    "maxX" : 947,
    "minY" : 326,
    "maxY" : 409,
    "prop" : {
      "x" : 813,
      "y" : 326,
      "width" : 134,
      "height" : 83
    },
    "textPosition" : {
      "x" : 813,
      "y" : 325
    },
    "connectors" : [ ]
  }, {
    "id" : 97239,
    "reactomeId" : 10228473,
    "displayName" : "FAS",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 54,
      "y" : 93
    },
    "minX" : 40,
    "maxX" : 117,
    "minY" : 64,
    "maxY" : 104,
    "prop" : {
      "x" : 40,
      "y" : 82,
      "width" : 29,
      "height" : 22
    },
    "textPosition" : {
      "x" : 43,
      "y" : 76
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 69,
          "y" : 82
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 69,
          "y" : 82
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 97237,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 72,
          "y" : 86
        },
        "to" : {
          "x" : 117,
          "y" : 64
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 97238,
    "reactomeId" : 10228469,
    "displayName" : "FASLG",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 73,
      "y" : 17
    },
    "minX" : 30,
    "maxX" : 123,
    "minY" : 0,
    "maxY" : 64,
    "prop" : {
      "x" : 30,
      "y" : 6,
      "width" : 87,
      "height" : 22
    },
    "textPosition" : {
      "x" : 50,
      "y" : 6
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 117,
          "y" : 6
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 117,
          "y" : 6
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 97237,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 83,
          "y" : 31
        },
        "to" : {
          "x" : 117,
          "y" : 64
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 97240,
    "reactomeId" : 10228475,
    "displayName" : "FASL:FAS Receptor monomer",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 236,
      "y" : 108
    },
    "minX" : 179,
    "maxX" : 325,
    "minY" : 76,
    "maxY" : 126,
    "prop" : {
      "x" : 179,
      "y" : 90,
      "width" : 114,
      "height" : 36
    },
    "textPosition" : {
      "x" : 201,
      "y" : 77
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 293,
          "y" : 90
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 293,
          "y" : 90
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 97237,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 97241,
      "type" : "INPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 3,
        "shape" : {
          "a" : {
            "x" : 313,
            "y" : 76
          },
          "b" : {
            "x" : 325,
            "y" : 88
          },
          "type" : "BOX",
          "empty" : true,
          "centre" : {
            "x" : 319,
            "y" : 82
          }
        }
      }
    } ]
  }, {
    "id" : 97242,
    "reactomeId" : 10228477,
    "displayName" : "FASL:FAS Receptor Trimer",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 434,
      "y" : 104
    },
    "minX" : 377,
    "maxX" : 497,
    "minY" : 80,
    "maxY" : 122,
    "prop" : {
      "x" : 377,
      "y" : 86,
      "width" : 114,
      "height" : 36
    },
    "textPosition" : {
      "x" : 380,
      "y" : 87
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 491,
          "y" : 86
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 491,
          "y" : 86
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 97241,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 97245,
    "reactomeId" : 10230618,
    "displayName" : "FASL:FAS trimer:FADD:CASP8(1-479)",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 930,
      "y" : 103
    },
    "minX" : 873,
    "maxX" : 993,
    "minY" : 72,
    "maxY" : 128,
    "prop" : {
      "x" : 873,
      "y" : 78,
      "width" : 114,
      "height" : 50
    },
    "textPosition" : {
      "x" : 875,
      "y" : 79
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 987,
          "y" : 78
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 987,
          "y" : 78
        }
      }
    },
    "connectors" : [ ]
  } ],
  "edges" : [ {
    "id" : 97237,
    "reactomeId" : 10231920,
    "displayName" : "FASL binds FAS Receptor",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 154,
      "y" : 67
    },
    "minX" : 117,
    "maxX" : 200,
    "minY" : 61,
    "maxY" : 87,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 117,
        "y" : 64
      },
      "to" : {
        "x" : 154,
        "y" : 67
      }
    }, {
      "from" : {
        "x" : 154,
        "y" : 67
      },
      "to" : {
        "x" : 200,
        "y" : 87
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 192,
        "y" : 88
      },
      "b" : {
        "x" : 200,
        "y" : 87
      },
      "c" : {
        "x" : 195,
        "y" : 81
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 195,
        "y" : 81
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 154,
        "y" : 67
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 154,
        "y" : 67
      }
    },
    "inputs" : [ {
      "id" : 97238,
      "points" : [ {
        "x" : 83,
        "y" : 31
      } ]
    }, {
      "id" : 97239,
      "points" : [ {
        "x" : 72,
        "y" : 86
      } ]
    } ],
    "outputs" : [ {
      "id" : 97240
    } ]
  }, {
    "id" : 97241,
    "reactomeId" : 10228479,
    "displayName" : "Trimerization of the FASL:FAS receptor complex",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 343,
      "y" : 75
    },
    "minX" : 296,
    "maxX" : 377,
    "minY" : 69,
    "maxY" : 90,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 296,
        "y" : 90
      },
      "to" : {
        "x" : 343,
        "y" : 75
      }
    }, {
      "from" : {
        "x" : 343,
        "y" : 75
      },
      "to" : {
        "x" : 377,
        "y" : 83
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 369,
        "y" : 85
      },
      "b" : {
        "x" : 377,
        "y" : 83
      },
      "c" : {
        "x" : 371,
        "y" : 78
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 371,
        "y" : 78
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 343,
        "y" : 75
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 343,
        "y" : 75
      }
    },
    "inputs" : [ {
      "id" : 97240,
      "stoichiometry" : 3
    } ],
    "outputs" : [ {
      "id" : 97242
    } ]
  } ],
  "compartments" : [ {
    "id" : 97247,
    "reactomeId" : 70101,
    "displayName" : "cytosol",
    "schemaClass" : "Compartment",
    "renderableClass" : "Compartment",
    "position" : {
      "x" : 506,
      "y" : 311
    },
    "minX" : 0,
    "maxX" : 1012,
    "minY" : 92,
    "maxY" : 530,
    "prop" : {
      "x" : 0,
      "y" : 92,
      "width" : 1012,
      "height" : 438
    },
    "textPosition" : {
      "x" : 476,
      "y" : 294
    },
    "insets" : {
      "x" : 10,
      "y" : 102,
      "width" : 992,
      "height" : 418
    },
    "bgColor" : {
      "r" : 250,
      "g" : 240,
      "b" : 240
    },
    "componentIds" : [ 97240, 97242, 97239, 97245, 97249, 97250, 97248 ]
  } ],
  "notes" : [ ],
  "links" : [ {
    "id" : 97249,
    "renderableClass" : "Interaction",
    "position" : {
      "x" : 906,
      "y" : 227
    },
    "minX" : 887,
    "maxX" : 925,
    "minY" : 131,
    "maxY" : 323,
    "interactionType" : "Activate",
    "segments" : [ {
      "from" : {
        "x" : 925,
        "y" : 131
      },
      "to" : {
        "x" : 887,
        "y" : 323
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 884,
        "y" : 315
      },
      "b" : {
        "x" : 887,
        "y" : 323
      },
      "c" : {
        "x" : 892,
        "y" : 317
      },
      "type" : "ARROW",
      "empty" : true,
      "centre" : {
        "x" : 892,
        "y" : 317
      }
    },
    "reactionShape" : {
      "a" : {
        "x" : 900,
        "y" : 221
      },
      "b" : {
        "x" : 912,
        "y" : 233
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 906,
        "y" : 227
      }
    },
    "inputs" : [ {
      "id" : 97245
    } ],
    "outputs" : [ {
      "id" : 97248
    } ]
  } ],
  "shadows" : [ ],
  "minX" : 0,
  "maxX" : 1012,
  "minY" : 0,
  "maxY" : 530,
  "disease" : false
}