{
  "dbId" : 10328529,
  "stableId" : "R-CFA-453279",
  "displayName" : "Mitotic G1 phase and G1/S transition",
  "nodes" : [ {
    "id" : 33793,
    "reactomeId" : 10241186,
    "displayName" : "CDKN1B",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 386,
      "y" : 1056
    },
    "minX" : 356,
    "maxX" : 422,
    "minY" : 1039,
    "maxY" : 1067,
    "prop" : {
      "x" : 356,
      "y" : 1045,
      "width" : 60,
      "height" : 22
    },
    "textPosition" : {
      "x" : 357,
      "y" : 1045
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 416,
          "y" : 1045
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 416,
          "y" : 1045
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 33792,
      "type" : "INPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 33794,
    "reactomeId" : 10227236,
    "displayName" : "CDKN1B",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 876,
      "y" : 1304
    },
    "minX" : 844,
    "maxX" : 914,
    "minY" : 1288,
    "maxY" : 1314,
    "prop" : {
      "x" : 844,
      "y" : 1294,
      "width" : 64,
      "height" : 20
    },
    "textPosition" : {
      "x" : 847,
      "y" : 1294
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 908,
          "y" : 1294
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 908,
          "y" : 1294
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 33792,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 33796,
    "reactomeId" : 29358,
    "displayName" : "ATP",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 1371,
      "y" : 587
    },
    "minX" : 1318,
    "maxX" : 1390,
    "minY" : 574,
    "maxY" : 609,
    "prop" : {
      "x" : 1353,
      "y" : 575,
      "width" : 36,
      "height" : 24
    },
    "textPosition" : {
      "x" : 1355,
      "y" : 576
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1384,
          "y" : 580
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1384,
          "y" : 580
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 33795,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1350,
          "y" : 594
        },
        "to" : {
          "x" : 1318,
          "y" : 609
        }
      } ],
      "stoichiometry" : {
        "value" : 3,
        "shape" : {
          "a" : {
            "x" : 1328,
            "y" : 595
          },
          "b" : {
            "x" : 1340,
            "y" : 607
          },
          "type" : "BOX",
          "empty" : true,
          "centre" : {
            "x" : 1334,
            "y" : 601
          }
        }
      }
    } ]
  }, {
    "id" : 33797,
    "reactomeId" : 10265798,
    "displayName" : "RBL2:E2F4,E2F5:TFDP1,TFDP2",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 1241,
      "y" : 552
    },
    "minX" : 1182,
    "maxX" : 1680,
    "minY" : 488,
    "maxY" : 609,
    "prop" : {
      "x" : 1182,
      "y" : 534,
      "width" : 118,
      "height" : 36
    },
    "textPosition" : {
      "x" : 1185,
      "y" : 535
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1300,
          "y" : 534
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1300,
          "y" : 534
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 33795,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1265,
          "y" : 573
        },
        "to" : {
          "x" : 1318,
          "y" : 609
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 33801,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1259,
          "y" : 531
        },
        "to" : {
          "x" : 1308,
          "y" : 488
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 33809,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1303,
          "y" : 549
        },
        "to" : {
          "x" : 1680,
          "y" : 535
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 33798,
    "reactomeId" : 10265805,
    "displayName" : "E2F4,E2F5:TFDP1,TFDP2",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 1235,
      "y" : 727
    },
    "minX" : 1188,
    "maxX" : 1289,
    "minY" : 665,
    "maxY" : 744,
    "prop" : {
      "x" : 1188,
      "y" : 711,
      "width" : 95,
      "height" : 33
    },
    "textPosition" : {
      "x" : 1190,
      "y" : 709
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1283,
          "y" : 711
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1283,
          "y" : 711
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 33795,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 1237,
          "y" : 708
        },
        "to" : {
          "x" : 1245,
          "y" : 665
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 1234,
          "y" : 700
        },
        "b" : {
          "x" : 1237,
          "y" : 708
        },
        "c" : {
          "x" : 1242,
          "y" : 702
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 1242,
          "y" : 702
        }
      }
    } ]
  }, {
    "id" : 33799,
    "reactomeId" : 113582,
    "displayName" : "ADP",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 1342,
      "y" : 737
    },
    "minX" : 1245,
    "maxX" : 1364,
    "minY" : 665,
    "maxY" : 748,
    "prop" : {
      "x" : 1322,
      "y" : 727,
      "width" : 41,
      "height" : 21
    },
    "textPosition" : {
      "x" : 1326,
      "y" : 727
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1358,
          "y" : 732
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1358,
          "y" : 732
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 33795,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 1327,
          "y" : 724
        },
        "to" : {
          "x" : 1245,
          "y" : 665
        }
      } ],
      "stoichiometry" : {
        "value" : 3,
        "shape" : {
          "a" : {
            "x" : 1280,
            "y" : 688
          },
          "b" : {
            "x" : 1292,
            "y" : 700
          },
          "type" : "BOX",
          "empty" : true,
          "centre" : {
            "x" : 1286,
            "y" : 694
          }
        }
      },
      "endShape" : {
        "a" : {
          "x" : 1319,
          "y" : 723
        },
        "b" : {
          "x" : 1327,
          "y" : 724
        },
        "c" : {
          "x" : 1324,
          "y" : 717
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 1324,
          "y" : 717
        }
      }
    } ]
  }, {
    "id" : 33800,
    "reactomeId" : 10265803,
    "displayName" : "phospho-RBL2",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 1070,
      "y" : 663
    },
    "minX" : 986,
    "maxX" : 1245,
    "minY" : 635,
    "maxY" : 698,
    "prop" : {
      "x" : 1023,
      "y" : 641,
      "width" : 95,
      "height" : 44
    },
    "textPosition" : {
      "x" : 1037,
      "y" : 645
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1118,
          "y" : 641
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1118,
          "y" : 641
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 33795,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 1121,
          "y" : 663
        },
        "to" : {
          "x" : 1245,
          "y" : 665
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 1128,
          "y" : 659
        },
        "b" : {
          "x" : 1121,
          "y" : 663
        },
        "c" : {
          "x" : 1128,
          "y" : 667
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 1128,
          "y" : 667
        }
      }
    }, {
      "edgeId" : 33815,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1020,
          "y" : 650
        },
        "to" : {
          "x" : 986,
          "y" : 641
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 33833,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1025,
          "y" : 688
        },
        "to" : {
          "x" : 999,
          "y" : 698
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 33802,
    "reactomeId" : 10267292,
    "displayName" : "p-MuvB complex",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 1263,
      "y" : 453
    },
    "minX" : 1097,
    "maxX" : 1323,
    "minY" : 436,
    "maxY" : 488,
    "prop" : {
      "x" : 1210,
      "y" : 442,
      "width" : 107,
      "height" : 22
    },
    "textPosition" : {
      "x" : 1210,
      "y" : 443
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1317,
          "y" : 442
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1317,
          "y" : 442
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 33801,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1277,
          "y" : 467
        },
        "to" : {
          "x" : 1308,
          "y" : 488
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 33804,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 1207,
          "y" : 457
        },
        "to" : {
          "x" : 1097,
          "y" : 466
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 1200,
          "y" : 462
        },
        "b" : {
          "x" : 1207,
          "y" : 457
        },
        "c" : {
          "x" : 1200,
          "y" : 454
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 1200,
          "y" : 454
        }
      }
    } ]
  }, {
    "id" : 33803,
    "reactomeId" : 10267294,
    "displayName" : "DREAM complex",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 1541,
      "y" : 488
    },
    "minX" : 1488,
    "maxX" : 1601,
    "minY" : 471,
    "maxY" : 499,
    "prop" : {
      "x" : 1488,
      "y" : 477,
      "width" : 107,
      "height" : 22
    },
    "textPosition" : {
      "x" : 1488,
      "y" : 478
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1595,
          "y" : 477
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1595,
          "y" : 477
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 33801,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 33805,
    "reactomeId" : 29358,
    "displayName" : "ATP",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 1001,
      "y" : 493
    },
    "minX" : 981,
    "maxX" : 1041,
    "minY" : 467,
    "maxY" : 504,
    "prop" : {
      "x" : 981,
      "y" : 482,
      "width" : 40,
      "height" : 22
    },
    "textPosition" : {
      "x" : 985,
      "y" : 482
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1016,
          "y" : 487
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1016,
          "y" : 487
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 33804,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1017,
          "y" : 479
        },
        "to" : {
          "x" : 1041,
          "y" : 467
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 33806,
    "reactomeId" : 10267300,
    "displayName" : "MuvB complex",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 958,
      "y" : 443
    },
    "minX" : 910,
    "maxX" : 1041,
    "minY" : 426,
    "maxY" : 467,
    "prop" : {
      "x" : 910,
      "y" : 432,
      "width" : 96,
      "height" : 22
    },
    "textPosition" : {
      "x" : 910,
      "y" : 433
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1006,
          "y" : 432
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1006,
          "y" : 432
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 33804,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 996,
          "y" : 457
        },
        "to" : {
          "x" : 1041,
          "y" : 467
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 33807,
    "reactomeId" : 113582,
    "displayName" : "ADP",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 1127,
      "y" : 494
    },
    "minX" : 1097,
    "maxX" : 1147,
    "minY" : 466,
    "maxY" : 507,
    "prop" : {
      "x" : 1108,
      "y" : 482,
      "width" : 38,
      "height" : 25
    },
    "textPosition" : {
      "x" : 1110,
      "y" : 484
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1141,
          "y" : 487
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1141,
          "y" : 487
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 33804,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 1113,
          "y" : 479
        },
        "to" : {
          "x" : 1097,
          "y" : 466
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 1105,
          "y" : 478
        },
        "b" : {
          "x" : 1113,
          "y" : 479
        },
        "c" : {
          "x" : 1110,
          "y" : 472
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 1110,
          "y" : 472
        }
      }
    } ]
  }, {
    "id" : 33808,
    "reactomeId" : 10267304,
    "displayName" : "DYRK1A",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 1066,
      "y" : 401
    },
    "minX" : 1038,
    "maxX" : 1101,
    "minY" : 384,
    "maxY" : 458,
    "prop" : {
      "x" : 1038,
      "y" : 390,
      "width" : 57,
      "height" : 22
    },
    "textPosition" : {
      "x" : 1039,
      "y" : 390
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1095,
          "y" : 390
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1095,
          "y" : 390
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 33804,
      "type" : "CATALYST",
      "segments" : [ {
        "from" : {
          "x" : 1066,
          "y" : 415
        },
        "to" : {
          "x" : 1068,
          "y" : 450
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 1068,
          "y" : 454
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1068,
          "y" : 454
        }
      }
    } ]
  }, {
    "id" : 33810,
    "reactomeId" : 10230289,
    "displayName" : "HDAC1",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 1954,
      "y" : 434
    },
    "minX" : 1680,
    "maxX" : 2067,
    "minY" : 417,
    "maxY" : 535,
    "prop" : {
      "x" : 1929,
      "y" : 423,
      "width" : 51,
      "height" : 22
    },
    "textPosition" : {
      "x" : 1929,
      "y" : 423
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1980,
          "y" : 423
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1980,
          "y" : 423
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 33809,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1926,
          "y" : 433
        },
        "to" : {
          "x" : 1789,
          "y" : 429
        }
      }, {
        "from" : {
          "x" : 1789,
          "y" : 429
        },
        "to" : {
          "x" : 1680,
          "y" : 535
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 33812,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1983,
          "y" : 438
        },
        "to" : {
          "x" : 2067,
          "y" : 452
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 33811,
    "reactomeId" : 10265825,
    "displayName" : "HDAC1:RBL2:E2F4,E2F5:TFDP1,TFDP2",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 1810,
      "y" : 554
    },
    "minX" : 1760,
    "maxX" : 1867,
    "minY" : 525,
    "maxY" : 577,
    "prop" : {
      "x" : 1760,
      "y" : 531,
      "width" : 101,
      "height" : 46
    },
    "textPosition" : {
      "x" : 1765,
      "y" : 528
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1861,
          "y" : 531
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1861,
          "y" : 531
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 33809,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 33813,
    "reactomeId" : 10265813,
    "displayName" : "RBL1:E2F4:TFDP1,TFDP2",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 2168,
      "y" : 434
    },
    "minX" : 2067,
    "maxX" : 2306,
    "minY" : 411,
    "maxY" : 588,
    "prop" : {
      "x" : 2120,
      "y" : 417,
      "width" : 97,
      "height" : 34
    },
    "textPosition" : {
      "x" : 2123,
      "y" : 416
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 2217,
          "y" : 417
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 2217,
          "y" : 417
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 33812,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 2117,
          "y" : 442
        },
        "to" : {
          "x" : 2067,
          "y" : 452
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 33853,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 2220,
          "y" : 442
        },
        "to" : {
          "x" : 2267,
          "y" : 452
        }
      }, {
        "from" : {
          "x" : 2267,
          "y" : 452
        },
        "to" : {
          "x" : 2306,
          "y" : 588
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 33814,
    "reactomeId" : 10265829,
    "displayName" : "HDAC1:RBL1:E2F4:TFDP1,TFDP2",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 2196,
      "y" : 493
    },
    "minX" : 2134,
    "maxX" : 2264,
    "minY" : 469,
    "maxY" : 511,
    "prop" : {
      "x" : 2134,
      "y" : 475,
      "width" : 124,
      "height" : 36
    },
    "textPosition" : {
      "x" : 2134,
      "y" : 476
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 2258,
          "y" : 475
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 2258,
          "y" : 475
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 33812,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 33816,
    "reactomeId" : 113518,
    "displayName" : "H2O",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 1036,
      "y" : 598
    },
    "minX" : 986,
    "maxX" : 1059,
    "minY" : 582,
    "maxY" : 641,
    "prop" : {
      "x" : 1015,
      "y" : 583,
      "width" : 43,
      "height" : 30
    },
    "textPosition" : {
      "x" : 1019,
      "y" : 587
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1053,
          "y" : 588
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1053,
          "y" : 588
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 33815,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1018,
          "y" : 616
        },
        "to" : {
          "x" : 986,
          "y" : 641
        }
      } ],
      "stoichiometry" : {
        "value" : 3,
        "shape" : {
          "a" : {
            "x" : 996,
            "y" : 622
          },
          "b" : {
            "x" : 1008,
            "y" : 634
          },
          "type" : "BOX",
          "empty" : true,
          "centre" : {
            "x" : 1002,
            "y" : 628
          }
        }
      }
    } ],
    "trivial" : true
  }, {
    "id" : 33817,
    "reactomeId" : 10265776,
    "displayName" : "RBL2",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 839,
      "y" : 666
    },
    "minX" : 820,
    "maxX" : 922,
    "minY" : 641,
    "maxY" : 677,
    "prop" : {
      "x" : 820,
      "y" : 655,
      "width" : 38,
      "height" : 22
    },
    "textPosition" : {
      "x" : 820,
      "y" : 655
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 858,
          "y" : 655
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 858,
          "y" : 655
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 33815,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 861,
          "y" : 660
        },
        "to" : {
          "x" : 922,
          "y" : 641
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 866,
          "y" : 654
        },
        "b" : {
          "x" : 861,
          "y" : 660
        },
        "c" : {
          "x" : 869,
          "y" : 662
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 869,
          "y" : 662
        }
      }
    } ]
  }, {
    "id" : 33818,
    "reactomeId" : 113550,
    "displayName" : "Pi",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 854,
      "y" : 609
    },
    "minX" : 841,
    "maxX" : 922,
    "minY" : 593,
    "maxY" : 641,
    "prop" : {
      "x" : 841,
      "y" : 594,
      "width" : 27,
      "height" : 30
    },
    "textPosition" : {
      "x" : 845,
      "y" : 598
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 863,
          "y" : 599
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 863,
          "y" : 599
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 33815,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 871,
          "y" : 615
        },
        "to" : {
          "x" : 922,
          "y" : 641
        }
      } ],
      "stoichiometry" : {
        "value" : 3,
        "shape" : {
          "a" : {
            "x" : 890,
            "y" : 622
          },
          "b" : {
            "x" : 902,
            "y" : 634
          },
          "type" : "BOX",
          "empty" : true,
          "centre" : {
            "x" : 896,
            "y" : 628
          }
        }
      },
      "endShape" : {
        "a" : {
          "x" : 879,
          "y" : 615
        },
        "b" : {
          "x" : 871,
          "y" : 615
        },
        "c" : {
          "x" : 875,
          "y" : 622
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 875,
          "y" : 622
        }
      }
    } ]
  }, {
    "id" : 33819,
    "reactomeId" : 10267343,
    "displayName" : "PP2A",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 955,
      "y" : 588
    },
    "minX" : 885,
    "maxX" : 2540,
    "minY" : 405,
    "maxY" : 645,
    "prop" : {
      "x" : 935,
      "y" : 577,
      "width" : 41,
      "height" : 22
    },
    "textPosition" : {
      "x" : 935,
      "y" : 578
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 976,
          "y" : 577
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 976,
          "y" : 577
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 33858,
      "type" : "CATALYST",
      "segments" : [ {
        "from" : {
          "x" : 950,
          "y" : 574
        },
        "to" : {
          "x" : 885,
          "y" : 427
        }
      }, {
        "from" : {
          "x" : 885,
          "y" : 427
        },
        "to" : {
          "x" : 2342,
          "y" : 405
        }
      }, {
        "from" : {
          "x" : 2342,
          "y" : 405
        },
        "to" : {
          "x" : 2534,
          "y" : 638
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 2536,
          "y" : 641
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 2536,
          "y" : 641
        }
      }
    }, {
      "edgeId" : 33815,
      "type" : "CATALYST",
      "segments" : [ {
        "from" : {
          "x" : 955,
          "y" : 602
        },
        "to" : {
          "x" : 955,
          "y" : 625
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 955,
          "y" : 629
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 955,
          "y" : 629
        }
      }
    } ]
  }, {
    "id" : 33821,
    "reactomeId" : 10267352,
    "displayName" : "Cyclin E/A:CDK2",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 1550,
      "y" : 1662
    },
    "minX" : 1425,
    "maxX" : 1617,
    "minY" : 1632,
    "maxY" : 1836,
    "prop" : {
      "x" : 1490,
      "y" : 1650,
      "width" : 121,
      "height" : 24
    },
    "textPosition" : {
      "x" : 1499,
      "y" : 1653
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1611,
          "y" : 1650
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1611,
          "y" : 1650
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 33820,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1549,
          "y" : 1677
        },
        "to" : {
          "x" : 1546,
          "y" : 1836
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 33824,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1534,
          "y" : 1677
        },
        "to" : {
          "x" : 1425,
          "y" : 1759
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 33827,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1557,
          "y" : 1677
        },
        "to" : {
          "x" : 1595,
          "y" : 1731
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 33830,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1520,
          "y" : 1647
        },
        "to" : {
          "x" : 1476,
          "y" : 1632
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 33822,
    "reactomeId" : 10265811,
    "displayName" : "RBL1",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 1533,
      "y" : 1869
    },
    "minX" : 1514,
    "maxX" : 1558,
    "minY" : 1836,
    "maxY" : 1880,
    "prop" : {
      "x" : 1514,
      "y" : 1858,
      "width" : 38,
      "height" : 22
    },
    "textPosition" : {
      "x" : 1514,
      "y" : 1858
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1552,
          "y" : 1858
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1552,
          "y" : 1858
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 33820,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1537,
          "y" : 1855
        },
        "to" : {
          "x" : 1546,
          "y" : 1836
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 33823,
    "reactomeId" : 10267366,
    "displayName" : "RBL1:Cyclin E/A:CDK2",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 1706,
      "y" : 1837
    },
    "minX" : 1654,
    "maxX" : 1764,
    "minY" : 1813,
    "maxY" : 1855,
    "prop" : {
      "x" : 1654,
      "y" : 1819,
      "width" : 104,
      "height" : 36
    },
    "textPosition" : {
      "x" : 1665,
      "y" : 1820
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1758,
          "y" : 1819
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1758,
          "y" : 1819
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 33820,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 33825,
    "reactomeId" : 10265813,
    "displayName" : "RBL1:E2F4:TFDP1,TFDP2",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 1283,
      "y" : 1729
    },
    "minX" : 1235,
    "maxX" : 1425,
    "minY" : 1705,
    "maxY" : 1759,
    "prop" : {
      "x" : 1235,
      "y" : 1711,
      "width" : 97,
      "height" : 37
    },
    "textPosition" : {
      "x" : 1238,
      "y" : 1713
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1332,
          "y" : 1711
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1332,
          "y" : 1711
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 33824,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1335,
          "y" : 1739
        },
        "to" : {
          "x" : 1425,
          "y" : 1759
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 33826,
    "reactomeId" : 10267362,
    "displayName" : "RBL1:E2F4:DP1/2:Cyclin E/A:CDK2",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 1424,
      "y" : 1856
    },
    "minX" : 1365,
    "maxX" : 1490,
    "minY" : 1832,
    "maxY" : 1874,
    "prop" : {
      "x" : 1365,
      "y" : 1838,
      "width" : 119,
      "height" : 36
    },
    "textPosition" : {
      "x" : 1365,
      "y" : 1839
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1484,
          "y" : 1838
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1484,
          "y" : 1838
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 33824,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 33828,
    "reactomeId" : 10265776,
    "displayName" : "RBL2",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 1584,
      "y" : 1760
    },
    "minX" : 1565,
    "maxX" : 1609,
    "minY" : 1731,
    "maxY" : 1771,
    "prop" : {
      "x" : 1565,
      "y" : 1749,
      "width" : 38,
      "height" : 22
    },
    "textPosition" : {
      "x" : 1565,
      "y" : 1749
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1603,
          "y" : 1749
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1603,
          "y" : 1749
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 33827,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1588,
          "y" : 1746
        },
        "to" : {
          "x" : 1595,
          "y" : 1731
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 33829,
    "reactomeId" : 10267358,
    "displayName" : "RBL2:Cyclin E/A:CDK2",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 1717,
      "y" : 1737
    },
    "minX" : 1665,
    "maxX" : 1775,
    "minY" : 1713,
    "maxY" : 1755,
    "prop" : {
      "x" : 1665,
      "y" : 1719,
      "width" : 104,
      "height" : 36
    },
    "textPosition" : {
      "x" : 1676,
      "y" : 1720
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1769,
          "y" : 1719
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1769,
          "y" : 1719
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 33827,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 33831,
    "reactomeId" : 10265798,
    "displayName" : "RBL2:E2F4,E2F5:TFDP1,TFDP2",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 1539,
      "y" : 1597
    },
    "minX" : 1474,
    "maxX" : 1610,
    "minY" : 1575,
    "maxY" : 1632,
    "prop" : {
      "x" : 1474,
      "y" : 1581,
      "width" : 130,
      "height" : 33
    },
    "textPosition" : {
      "x" : 1483,
      "y" : 1579
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1604,
          "y" : 1581
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1604,
          "y" : 1581
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 33830,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1509,
          "y" : 1617
        },
        "to" : {
          "x" : 1476,
          "y" : 1632
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 33832,
    "reactomeId" : 10267354,
    "displayName" : "RBL2:E2F4/5:DP1/2:Cyclin E/A:CDK2",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 1331,
      "y" : 1632
    },
    "minX" : 1266,
    "maxX" : 1403,
    "minY" : 1608,
    "maxY" : 1650,
    "prop" : {
      "x" : 1266,
      "y" : 1614,
      "width" : 131,
      "height" : 36
    },
    "textPosition" : {
      "x" : 1266,
      "y" : 1615
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1397,
          "y" : 1614
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1397,
          "y" : 1614
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 33830,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 33834,
    "reactomeId" : 10241211,
    "displayName" : "CUL1:SKP1:SKP2:CKS1B",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 1070,
      "y" : 735
    },
    "minX" : 999,
    "maxX" : 1128,
    "minY" : 698,
    "maxY" : 780,
    "prop" : {
      "x" : 1019,
      "y" : 717,
      "width" : 103,
      "height" : 36
    },
    "textPosition" : {
      "x" : 1029,
      "y" : 718
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1122,
          "y" : 717
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1122,
          "y" : 717
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 33833,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1035,
          "y" : 714
        },
        "to" : {
          "x" : 999,
          "y" : 698
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 33836,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 1046,
          "y" : 756
        },
        "to" : {
          "x" : 1011,
          "y" : 780
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 1043,
          "y" : 763
        },
        "b" : {
          "x" : 1046,
          "y" : 756
        },
        "c" : {
          "x" : 1038,
          "y" : 757
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 1038,
          "y" : 757
        }
      }
    } ]
  }, {
    "id" : 33835,
    "reactomeId" : 10267370,
    "displayName" : "p-T401,S672,1035-RBL2:SCF(Skp2):Cks1",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 835,
      "y" : 738
    },
    "minX" : 785,
    "maxX" : 974,
    "minY" : 707,
    "maxY" : 781,
    "prop" : {
      "x" : 785,
      "y" : 713,
      "width" : 101,
      "height" : 50
    },
    "textPosition" : {
      "x" : 785,
      "y" : 714
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 886,
          "y" : 713
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 886,
          "y" : 713
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 33833,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 33836,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 889,
          "y" : 761
        },
        "to" : {
          "x" : 927,
          "y" : 781
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 33836,
      "type" : "CATALYST",
      "segments" : [ {
        "from" : {
          "x" : 889,
          "y" : 737
        },
        "to" : {
          "x" : 969,
          "y" : 736
        }
      }, {
        "from" : {
          "x" : 969,
          "y" : 736
        },
        "to" : {
          "x" : 970,
          "y" : 765
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 970,
          "y" : 769
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 970,
          "y" : 769
        }
      }
    } ]
  }, {
    "id" : 33837,
    "reactomeId" : 10226336,
    "displayName" : "Ub",
    "schemaClass" : "DefinedSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 870,
      "y" : 1081
    },
    "minX" : 839,
    "maxX" : 927,
    "minY" : 781,
    "maxY" : 1092,
    "prop" : {
      "x" : 839,
      "y" : 1070,
      "width" : 63,
      "height" : 22
    },
    "textPosition" : {
      "x" : 858,
      "y" : 1070
    },
    "connectors" : [ {
      "edgeId" : 33836,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 872,
          "y" : 1064
        },
        "to" : {
          "x" : 927,
          "y" : 781
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 33838,
    "reactomeId" : 10267374,
    "displayName" : "Ub-p-T401,S672,1035-RBL2",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 1087,
      "y" : 1013
    },
    "minX" : 1011,
    "maxX" : 1152,
    "minY" : 780,
    "maxY" : 1031,
    "prop" : {
      "x" : 1029,
      "y" : 995,
      "width" : 117,
      "height" : 36
    },
    "textPosition" : {
      "x" : 1031,
      "y" : 996
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1146,
          "y" : 995
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1146,
          "y" : 995
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 33836,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 1081,
          "y" : 992
        },
        "to" : {
          "x" : 1011,
          "y" : 780
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 1075,
          "y" : 987
        },
        "b" : {
          "x" : 1081,
          "y" : 992
        },
        "c" : {
          "x" : 1083,
          "y" : 984
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 1083,
          "y" : 984
        }
      }
    } ]
  }, {
    "id" : 33840,
    "reactomeId" : 10312644,
    "displayName" : "Cyclin D",
    "schemaClass" : "CandidateSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 166,
      "y" : 789
    },
    "minX" : 138,
    "maxX" : 205,
    "minY" : 778,
    "maxY" : 827,
    "prop" : {
      "x" : 138,
      "y" : 778,
      "width" : 57,
      "height" : 22
    },
    "textPosition" : {
      "x" : 138,
      "y" : 778
    },
    "connectors" : [ {
      "edgeId" : 33839,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 177,
          "y" : 806
        },
        "to" : {
          "x" : 205,
          "y" : 827
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 33841,
    "reactomeId" : 10312646,
    "displayName" : "CDK4,CDK6:CCND",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 299,
      "y" : 771
    },
    "minX" : 268,
    "maxX" : 336,
    "minY" : 740,
    "maxY" : 812,
    "prop" : {
      "x" : 268,
      "y" : 746,
      "width" : 62,
      "height" : 50
    },
    "textPosition" : {
      "x" : 277,
      "y" : 747
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 330,
          "y" : 746
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 330,
          "y" : 746
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 33839,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 33842,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 320,
          "y" : 799
        },
        "to" : {
          "x" : 335,
          "y" : 812
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 33843,
    "reactomeId" : 10312653,
    "displayName" : "CDKN1A,CDKN1B,(CDKN1C)",
    "schemaClass" : "CandidateSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 338,
      "y" : 889
    },
    "minX" : 301,
    "maxX" : 376,
    "minY" : 812,
    "maxY" : 914,
    "prop" : {
      "x" : 301,
      "y" : 865,
      "width" : 75,
      "height" : 49
    },
    "textPosition" : {
      "x" : 305,
      "y" : 865
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 204
    },
    "fgColor" : {
      "r" : 0,
      "g" : 0,
      "b" : 0
    },
    "connectors" : [ {
      "edgeId" : 33842,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 337,
          "y" : 859
        },
        "to" : {
          "x" : 335,
          "y" : 812
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 33844,
    "reactomeId" : 10312655,
    "displayName" : "CDK4,CDK6:CCND:CDKN1A,CDKN1B,(CDKN1C)",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 409,
      "y" : 725
    },
    "minX" : 374,
    "maxX" : 515,
    "minY" : 673,
    "maxY" : 771,
    "prop" : {
      "x" : 374,
      "y" : 679,
      "width" : 70,
      "height" : 92
    },
    "textPosition" : {
      "x" : 375,
      "y" : 680
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 444,
          "y" : 679
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 444,
          "y" : 679
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 33842,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 33845,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 447,
          "y" : 718
        },
        "to" : {
          "x" : 515,
          "y" : 706
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 33846,
    "reactomeId" : 113592,
    "displayName" : "ATP",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 496,
      "y" : 758
    },
    "minX" : 476,
    "maxX" : 517,
    "minY" : 706,
    "maxY" : 773,
    "prop" : {
      "x" : 476,
      "y" : 743,
      "width" : 40,
      "height" : 30
    },
    "textPosition" : {
      "x" : 480,
      "y" : 747
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 511,
          "y" : 748
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 511,
          "y" : 748
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 33845,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 501,
          "y" : 740
        },
        "to" : {
          "x" : 515,
          "y" : 706
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 33847,
    "reactomeId" : 10312723,
    "displayName" : "CDK4/6:CCND:p-Y77-CDKN1A,p-Y88-CDKN1B,(p-Y91-CDKN1C)",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 646,
      "y" : 693
    },
    "minX" : 571,
    "maxX" : 708,
    "minY" : 651,
    "maxY" : 730,
    "prop" : {
      "x" : 591,
      "y" : 657,
      "width" : 111,
      "height" : 73
    },
    "textPosition" : {
      "x" : 593,
      "y" : 667
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 702,
          "y" : 657
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 702,
          "y" : 657
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 33845,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 588,
          "y" : 707
        },
        "to" : {
          "x" : 571,
          "y" : 712
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 582,
          "y" : 713
        },
        "b" : {
          "x" : 588,
          "y" : 707
        },
        "c" : {
          "x" : 580,
          "y" : 705
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 580,
          "y" : 705
        }
      }
    } ]
  }, {
    "id" : 33848,
    "reactomeId" : 29370,
    "displayName" : "ADP",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 578,
      "y" : 760
    },
    "minX" : 558,
    "maxX" : 600,
    "minY" : 712,
    "maxY" : 775,
    "prop" : {
      "x" : 558,
      "y" : 745,
      "width" : 41,
      "height" : 30
    },
    "textPosition" : {
      "x" : 562,
      "y" : 749
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 594,
          "y" : 750
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 594,
          "y" : 750
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 33845,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 575,
          "y" : 742
        },
        "to" : {
          "x" : 571,
          "y" : 712
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 570,
          "y" : 736
        },
        "b" : {
          "x" : 575,
          "y" : 742
        },
        "c" : {
          "x" : 578,
          "y" : 735
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 578,
          "y" : 735
        }
      }
    } ]
  }, {
    "id" : 33849,
    "reactomeId" : 10312743,
    "displayName" : "(p-Y342-PTK6,p-Y397-LYN,p-Y226,Y393-ABL1,p-Y419-SRC,p-5Y-JAK2)",
    "schemaClass" : "CandidateSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 546,
      "y" : 606
    },
    "minX" : 464,
    "maxX" : 629,
    "minY" : 581,
    "maxY" : 703,
    "prop" : {
      "x" : 464,
      "y" : 581,
      "width" : 165,
      "height" : 51
    },
    "textPosition" : {
      "x" : 465,
      "y" : 582
    },
    "connectors" : [ {
      "edgeId" : 33845,
      "type" : "CATALYST",
      "segments" : [ {
        "from" : {
          "x" : 545,
          "y" : 638
        },
        "to" : {
          "x" : 545,
          "y" : 695
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 545,
          "y" : 699
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 545,
          "y" : 699
        }
      }
    } ]
  }, {
    "id" : 33851,
    "reactomeId" : 10312764,
    "displayName" : "CDK4,CDK6:CCND:CDKN1A,CDKN1B,(CDKN1C); CDK4,CDK6:CCND; (CDK4,CDK6:CCND:p-Y88-CDKN1B)",
    "schemaClass" : "CandidateSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 554,
      "y" : 982
    },
    "minX" : 441,
    "maxX" : 668,
    "minY" : 950,
    "maxY" : 1014,
    "prop" : {
      "x" : 441,
      "y" : 950,
      "width" : 227,
      "height" : 64
    },
    "textPosition" : {
      "x" : 442,
      "y" : 957
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "fgColor" : {
      "r" : 0,
      "g" : 0,
      "b" : 0
    },
    "connectors" : [ {
      "edgeId" : 33850,
      "type" : "INPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 33852,
    "reactomeId" : 10312790,
    "displayName" : "CDK4,CDK6:CCND:CDKN1A,CDKN1B,(CDKN1C); CDK4,CDK6:CCND; (CDK4,CDK6:CCND:p-Y88-CDKN1B)",
    "schemaClass" : "CandidateSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 956,
      "y" : 1156
    },
    "minX" : 843,
    "maxX" : 1070,
    "minY" : 1126,
    "maxY" : 1187,
    "prop" : {
      "x" : 843,
      "y" : 1126,
      "width" : 227,
      "height" : 61
    },
    "textPosition" : {
      "x" : 844,
      "y" : 1132
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "fgColor" : {
      "r" : 0,
      "g" : 0,
      "b" : 0
    },
    "connectors" : [ {
      "edgeId" : 33850,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 33854,
    "reactomeId" : 29358,
    "displayName" : "ATP",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 2366,
      "y" : 582
    },
    "minX" : 2306,
    "maxX" : 2384,
    "minY" : 569,
    "maxY" : 595,
    "prop" : {
      "x" : 2349,
      "y" : 570,
      "width" : 34,
      "height" : 25
    },
    "textPosition" : {
      "x" : 2350,
      "y" : 572
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 2378,
          "y" : 575
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 2378,
          "y" : 575
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 33853,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 2346,
          "y" : 583
        },
        "to" : {
          "x" : 2306,
          "y" : 588
        }
      } ],
      "stoichiometry" : {
        "value" : 4,
        "shape" : {
          "a" : {
            "x" : 2320,
            "y" : 579
          },
          "b" : {
            "x" : 2332,
            "y" : 591
          },
          "type" : "BOX",
          "empty" : true,
          "centre" : {
            "x" : 2326,
            "y" : 585
          }
        }
      }
    } ]
  }, {
    "id" : 33855,
    "reactomeId" : 10265821,
    "displayName" : "E2F4:TFDP1,TFDP2",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 2272,
      "y" : 728
    },
    "minX" : 2240,
    "maxX" : 2315,
    "minY" : 645,
    "maxY" : 752,
    "prop" : {
      "x" : 2240,
      "y" : 705,
      "width" : 64,
      "height" : 47
    },
    "textPosition" : {
      "x" : 2246,
      "y" : 703
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 2304,
          "y" : 705
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 2304,
          "y" : 705
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 33853,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 2284,
          "y" : 702
        },
        "to" : {
          "x" : 2315,
          "y" : 645
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 2284,
          "y" : 694
        },
        "b" : {
          "x" : 2284,
          "y" : 702
        },
        "c" : {
          "x" : 2291,
          "y" : 698
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 2291,
          "y" : 698
        }
      }
    } ]
  }, {
    "id" : 33856,
    "reactomeId" : 10265819,
    "displayName" : "phospho-RBL1",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 2408,
      "y" : 731
    },
    "minX" : 2315,
    "maxX" : 2545,
    "minY" : 645,
    "maxY" : 752,
    "prop" : {
      "x" : 2344,
      "y" : 710,
      "width" : 129,
      "height" : 42
    },
    "textPosition" : {
      "x" : 2360,
      "y" : 720
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 2473,
          "y" : 710
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 2473,
          "y" : 710
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 33858,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 2476,
          "y" : 710
        },
        "to" : {
          "x" : 2545,
          "y" : 688
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 33853,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 2385,
          "y" : 707
        },
        "to" : {
          "x" : 2315,
          "y" : 645
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 2377,
          "y" : 705
        },
        "b" : {
          "x" : 2385,
          "y" : 707
        },
        "c" : {
          "x" : 2382,
          "y" : 699
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 2382,
          "y" : 699
        }
      }
    } ]
  }, {
    "id" : 33857,
    "reactomeId" : 113582,
    "displayName" : "ADP",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 2390,
      "y" : 636
    },
    "minX" : 2315,
    "maxX" : 2411,
    "minY" : 624,
    "maxY" : 648,
    "prop" : {
      "x" : 2371,
      "y" : 625,
      "width" : 39,
      "height" : 23
    },
    "textPosition" : {
      "x" : 2374,
      "y" : 626
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 2405,
          "y" : 630
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 2405,
          "y" : 630
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 33853,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 2368,
          "y" : 638
        },
        "to" : {
          "x" : 2315,
          "y" : 645
        }
      } ],
      "stoichiometry" : {
        "value" : 4,
        "shape" : {
          "a" : {
            "x" : 2335,
            "y" : 635
          },
          "b" : {
            "x" : 2347,
            "y" : 647
          },
          "type" : "BOX",
          "empty" : true,
          "centre" : {
            "x" : 2341,
            "y" : 641
          }
        }
      },
      "endShape" : {
        "a" : {
          "x" : 2362,
          "y" : 643
        },
        "b" : {
          "x" : 2368,
          "y" : 638
        },
        "c" : {
          "x" : 2361,
          "y" : 635
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 2361,
          "y" : 635
        }
      }
    } ]
  }, {
    "id" : 33859,
    "reactomeId" : 113518,
    "displayName" : "H2O",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 2536,
      "y" : 735
    },
    "minX" : 2515,
    "maxX" : 2559,
    "minY" : 688,
    "maxY" : 750,
    "prop" : {
      "x" : 2515,
      "y" : 720,
      "width" : 43,
      "height" : 30
    },
    "textPosition" : {
      "x" : 2519,
      "y" : 724
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 2553,
          "y" : 725
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 2553,
          "y" : 725
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 33858,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 2538,
          "y" : 717
        },
        "to" : {
          "x" : 2545,
          "y" : 688
        }
      } ],
      "stoichiometry" : {
        "value" : 4,
        "shape" : {
          "a" : {
            "x" : 2535,
            "y" : 696
          },
          "b" : {
            "x" : 2547,
            "y" : 708
          },
          "type" : "BOX",
          "empty" : true,
          "centre" : {
            "x" : 2541,
            "y" : 702
          }
        }
      }
    } ],
    "trivial" : true
  }, {
    "id" : 33860,
    "reactomeId" : 10265811,
    "displayName" : "RBL1",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 2147,
      "y" : 695
    },
    "minX" : 2128,
    "maxX" : 2580,
    "minY" : 599,
    "maxY" : 782,
    "prop" : {
      "x" : 2128,
      "y" : 684,
      "width" : 38,
      "height" : 22
    },
    "textPosition" : {
      "x" : 2128,
      "y" : 684
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 2166,
          "y" : 684
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 2166,
          "y" : 684
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 33858,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 2154,
          "y" : 709
        },
        "to" : {
          "x" : 2206,
          "y" : 782
        }
      }, {
        "from" : {
          "x" : 2206,
          "y" : 782
        },
        "to" : {
          "x" : 2580,
          "y" : 779
        }
      }, {
        "from" : {
          "x" : 2580,
          "y" : 779
        },
        "to" : {
          "x" : 2564,
          "y" : 599
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 2161,
          "y" : 712
        },
        "b" : {
          "x" : 2154,
          "y" : 709
        },
        "c" : {
          "x" : 2155,
          "y" : 717
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 2155,
          "y" : 717
        }
      }
    } ]
  }, {
    "id" : 33861,
    "reactomeId" : 113550,
    "displayName" : "Pi",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 2616,
      "y" : 549
    },
    "minX" : 2564,
    "maxX" : 2631,
    "minY" : 533,
    "maxY" : 599,
    "prop" : {
      "x" : 2603,
      "y" : 534,
      "width" : 27,
      "height" : 30
    },
    "textPosition" : {
      "x" : 2607,
      "y" : 538
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 2625,
          "y" : 539
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 2625,
          "y" : 539
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 33858,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 2600,
          "y" : 561
        },
        "to" : {
          "x" : 2564,
          "y" : 599
        }
      } ],
      "stoichiometry" : {
        "value" : 4,
        "shape" : {
          "a" : {
            "x" : 2576,
            "y" : 574
          },
          "b" : {
            "x" : 2588,
            "y" : 586
          },
          "type" : "BOX",
          "empty" : true,
          "centre" : {
            "x" : 2582,
            "y" : 580
          }
        }
      },
      "endShape" : {
        "a" : {
          "x" : 2598,
          "y" : 569
        },
        "b" : {
          "x" : 2600,
          "y" : 561
        },
        "c" : {
          "x" : 2592,
          "y" : 563
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 2592,
          "y" : 563
        }
      }
    } ]
  }, {
    "id" : 33863,
    "reactomeId" : 10281625,
    "displayName" : "E2F1,E2F2,E2F3:TFDP1,TFDP2",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 1909,
      "y" : 1187
    },
    "minX" : 1804,
    "maxX" : 1971,
    "minY" : 1163,
    "maxY" : 1205,
    "prop" : {
      "x" : 1853,
      "y" : 1169,
      "width" : 112,
      "height" : 36
    },
    "textPosition" : {
      "x" : 1866,
      "y" : 1156
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1965,
          "y" : 1169
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1965,
          "y" : 1169
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 33862,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1850,
          "y" : 1181
        },
        "to" : {
          "x" : 1804,
          "y" : 1176
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 33864,
    "reactomeId" : 10317070,
    "displayName" : "RB1:E2F1,E2F2,E2F3:TFDP1,TFDP2:",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 1898,
      "y" : 1252
    },
    "minX" : 1830,
    "maxX" : 1973,
    "minY" : 1227,
    "maxY" : 1271,
    "prop" : {
      "x" : 1830,
      "y" : 1233,
      "width" : 137,
      "height" : 38
    },
    "textPosition" : {
      "x" : 1834,
      "y" : 1236
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1967,
          "y" : 1233
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1967,
          "y" : 1233
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 33862,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 33866,
    "reactomeId" : 10319790,
    "displayName" : "RB1",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 649,
      "y" : 1209
    },
    "minX" : 632,
    "maxX" : 673,
    "minY" : 1192,
    "maxY" : 1220,
    "prop" : {
      "x" : 632,
      "y" : 1198,
      "width" : 35,
      "height" : 22
    },
    "textPosition" : {
      "x" : 633,
      "y" : 1198
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 667,
          "y" : 1198
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 667,
          "y" : 1198
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 33865,
      "type" : "INPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 33868,
    "reactomeId" : 10227260,
    "displayName" : "p-T172-CDK4:CCND",
    "schemaClass" : "DefinedSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 1800,
      "y" : 945
    },
    "minX" : 1750,
    "maxX" : 1925,
    "minY" : 930,
    "maxY" : 984,
    "prop" : {
      "x" : 1750,
      "y" : 930,
      "width" : 100,
      "height" : 30
    },
    "textPosition" : {
      "x" : 1754,
      "y" : 928
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "fgColor" : {
      "r" : 0,
      "g" : 0,
      "b" : 0
    },
    "connectors" : [ {
      "edgeId" : 33867,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1848,
          "y" : 966
        },
        "to" : {
          "x" : 1925,
          "y" : 984
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 33869,
    "reactomeId" : 9754127,
    "displayName" : "CDK4 inhibitors",
    "schemaClass" : "DefinedSet",
    "renderableClass" : "EntitySetDrug",
    "position" : {
      "x" : 1878,
      "y" : 1020
    },
    "minX" : 1836,
    "maxX" : 1925,
    "minY" : 984,
    "maxY" : 1038,
    "prop" : {
      "x" : 1836,
      "y" : 1002,
      "width" : 84,
      "height" : 36
    },
    "textPosition" : {
      "x" : 1845,
      "y" : 1002
    },
    "bgColor" : {
      "r" : 184,
      "g" : 154,
      "b" : 230
    },
    "fgColor" : {
      "r" : 161,
      "g" : 1,
      "b" : 2
    },
    "connectors" : [ {
      "edgeId" : 33867,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1901,
          "y" : 996
        },
        "to" : {
          "x" : 1925,
          "y" : 984
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 33871,
    "reactomeId" : 10227252,
    "displayName" : "p-T177-CDK6:CCND",
    "schemaClass" : "DefinedSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 1809,
      "y" : 879
    },
    "minX" : 1759,
    "maxX" : 1919,
    "minY" : 863,
    "maxY" : 934,
    "prop" : {
      "x" : 1759,
      "y" : 863,
      "width" : 100,
      "height" : 32
    },
    "textPosition" : {
      "x" : 1763,
      "y" : 862
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "fgColor" : {
      "r" : 0,
      "g" : 0,
      "b" : 0
    },
    "connectors" : [ {
      "edgeId" : 33870,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1841,
          "y" : 901
        },
        "to" : {
          "x" : 1919,
          "y" : 934
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 33872,
    "reactomeId" : 9754132,
    "displayName" : "CDK6 inhibitors",
    "schemaClass" : "DefinedSet",
    "renderableClass" : "EntitySetDrug",
    "position" : {
      "x" : 1972,
      "y" : 886
    },
    "minX" : 1919,
    "maxX" : 2015,
    "minY" : 871,
    "maxY" : 934,
    "prop" : {
      "x" : 1930,
      "y" : 871,
      "width" : 85,
      "height" : 30
    },
    "textPosition" : {
      "x" : 1939,
      "y" : 869
    },
    "bgColor" : {
      "r" : 184,
      "g" : 154,
      "b" : 230
    },
    "fgColor" : {
      "r" : 161,
      "g" : 1,
      "b" : 2
    },
    "connectors" : [ {
      "edgeId" : 33870,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1955,
          "y" : 907
        },
        "to" : {
          "x" : 1919,
          "y" : 934
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 33873,
    "reactomeId" : 10243290,
    "displayName" : "CDKN1A,CDKN1B",
    "schemaClass" : "DefinedSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 265,
      "y" : 1069
    },
    "minX" : 233,
    "maxX" : 298,
    "minY" : 1052,
    "maxY" : 1086,
    "prop" : {
      "x" : 233,
      "y" : 1052,
      "width" : 65,
      "height" : 34
    },
    "textPosition" : {
      "x" : 235,
      "y" : 1052
    },
    "connectors" : [ ]
  }, {
    "id" : 33881,
    "reactomeId" : 10226296,
    "displayName" : "CDT1",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 1968,
      "y" : 1714
    },
    "minX" : 1947,
    "maxX" : 1995,
    "minY" : 1697,
    "maxY" : 1725,
    "prop" : {
      "x" : 1947,
      "y" : 1703,
      "width" : 42,
      "height" : 22
    },
    "textPosition" : {
      "x" : 1948,
      "y" : 1703
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1989,
          "y" : 1703
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1989,
          "y" : 1703
        }
      }
    },
    "connectors" : [ ]
  }, {
    "id" : 33882,
    "reactomeId" : 10226653,
    "displayName" : "CDC45",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 2663,
      "y" : 2155
    },
    "minX" : 2638,
    "maxX" : 2694,
    "minY" : 2138,
    "maxY" : 2166,
    "prop" : {
      "x" : 2638,
      "y" : 2144,
      "width" : 50,
      "height" : 22
    },
    "textPosition" : {
      "x" : 2638,
      "y" : 2144
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 2688,
          "y" : 2144
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 2688,
          "y" : 2144
        }
      }
    },
    "connectors" : [ ]
  }, {
    "id" : 33895,
    "reactomeId" : 10306390,
    "displayName" : "Ghost homologue of p-Y342-PTK6",
    "schemaClass" : "GenomeEncodedEntity",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 207,
      "y" : 367
    },
    "minX" : 154,
    "maxX" : 266,
    "minY" : 349,
    "maxY" : 380,
    "prop" : {
      "x" : 154,
      "y" : 355,
      "width" : 106,
      "height" : 25
    },
    "textPosition" : {
      "x" : 158,
      "y" : 343
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 260,
          "y" : 355
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 260,
          "y" : 355
        }
      }
    },
    "connectors" : [ ]
  }, {
    "id" : 33900,
    "reactomeId" : 10329121,
    "displayName" : "PIP3 activates AKT signaling",
    "schemaClass" : "Pathway",
    "renderableClass" : "EncapsulatedNode",
    "position" : {
      "x" : 255,
      "y" : 1354
    },
    "minX" : 194,
    "maxX" : 316,
    "minY" : 1328,
    "maxY" : 1381,
    "prop" : {
      "x" : 194,
      "y" : 1328,
      "width" : 122,
      "height" : 53
    },
    "textPosition" : {
      "x" : 201,
      "y" : 1333
    },
    "connectors" : [ ]
  }, {
    "id" : 33901,
    "reactomeId" : 10329605,
    "displayName" : "Oncogene Induced Senescence",
    "schemaClass" : "Pathway",
    "renderableClass" : "EncapsulatedNode",
    "position" : {
      "x" : 55,
      "y" : 920
    },
    "minX" : 0,
    "maxX" : 111,
    "minY" : 888,
    "maxY" : 953,
    "prop" : {
      "x" : 0,
      "y" : 888,
      "width" : 111,
      "height" : 65
    },
    "textPosition" : {
      "x" : 9,
      "y" : 892
    },
    "connectors" : [ ]
  }, {
    "id" : 33902,
    "reactomeId" : 10329405,
    "displayName" : "Oxidative Stress Induced Senescence",
    "schemaClass" : "Pathway",
    "renderableClass" : "EncapsulatedNode",
    "position" : {
      "x" : 112,
      "y" : 713
    },
    "minX" : 52,
    "maxX" : 172,
    "minY" : 680,
    "maxY" : 746,
    "prop" : {
      "x" : 52,
      "y" : 680,
      "width" : 120,
      "height" : 66
    },
    "textPosition" : {
      "x" : 52,
      "y" : 684
    },
    "connectors" : [ ]
  }, {
    "id" : 33903,
    "reactomeId" : 10329607,
    "displayName" : "Senescence-Associated Secretory Phenotype (SASP)",
    "schemaClass" : "Pathway",
    "renderableClass" : "EncapsulatedNode",
    "position" : {
      "x" : 145,
      "y" : 1103
    },
    "minX" : 74,
    "maxX" : 217,
    "minY" : 1059,
    "maxY" : 1148,
    "prop" : {
      "x" : 74,
      "y" : 1059,
      "width" : 143,
      "height" : 89
    },
    "textPosition" : {
      "x" : 81,
      "y" : 1068
    },
    "connectors" : [ ]
  }, {
    "id" : 33904,
    "reactomeId" : 10331453,
    "displayName" : "Signaling by PTK6",
    "schemaClass" : "Pathway",
    "renderableClass" : "EncapsulatedNode",
    "position" : {
      "x" : 156,
      "y" : 457
    },
    "minX" : 101,
    "maxX" : 211,
    "minY" : 428,
    "maxY" : 487,
    "prop" : {
      "x" : 101,
      "y" : 428,
      "width" : 110,
      "height" : 59
    },
    "textPosition" : {
      "x" : 108,
      "y" : 436
    },
    "connectors" : [ ]
  }, {
    "id" : 33905,
    "reactomeId" : 10329473,
    "displayName" : "Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer",
    "schemaClass" : "Pathway",
    "renderableClass" : "EncapsulatedNode",
    "position" : {
      "x" : 128,
      "y" : 1271
    },
    "minX" : 56,
    "maxX" : 200,
    "minY" : 1226,
    "maxY" : 1316,
    "prop" : {
      "x" : 56,
      "y" : 1226,
      "width" : 144,
      "height" : 90
    },
    "textPosition" : {
      "x" : 57,
      "y" : 1235
    },
    "connectors" : [ ]
  }, {
    "id" : 33912,
    "reactomeId" : 10227118,
    "displayName" : "CCNE1",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 643,
      "y" : 1785
    },
    "minX" : 619,
    "maxX" : 674,
    "minY" : 1768,
    "maxY" : 1796,
    "prop" : {
      "x" : 619,
      "y" : 1774,
      "width" : 49,
      "height" : 22
    },
    "textPosition" : {
      "x" : 619,
      "y" : 1774
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 668,
          "y" : 1774
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 668,
          "y" : 1774
        }
      }
    },
    "connectors" : [ ]
  }, {
    "id" : 33919,
    "reactomeId" : 10328525,
    "displayName" : "Activation of the pre-replicative complex",
    "schemaClass" : "Pathway",
    "renderableClass" : "ProcessNode",
    "position" : {
      "x" : 2204,
      "y" : 2132
    },
    "minX" : 2125,
    "maxX" : 2283,
    "minY" : 2096,
    "maxY" : 2168,
    "prop" : {
      "x" : 2125,
      "y" : 2096,
      "width" : 158,
      "height" : 72
    },
    "textPosition" : {
      "x" : 2130,
      "y" : 2110
    },
    "connectors" : [ ]
  }, {
    "id" : 33729,
    "reactomeId" : 10227158,
    "displayName" : "RB1",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 1641,
      "y" : 1145
    },
    "minX" : 1580,
    "maxX" : 1849,
    "minY" : 1118,
    "maxY" : 1176,
    "prop" : {
      "x" : 1580,
      "y" : 1124,
      "width" : 123,
      "height" : 43
    },
    "textPosition" : {
      "x" : 1625,
      "y" : 1135
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1703,
          "y" : 1124
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1703,
          "y" : 1124
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 33728,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1706,
          "y" : 1143
        },
        "to" : {
          "x" : 1849,
          "y" : 1140
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 33862,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1706,
          "y" : 1156
        },
        "to" : {
          "x" : 1804,
          "y" : 1176
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 33865,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 33730,
    "reactomeId" : 29358,
    "displayName" : "ATP",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 1768,
      "y" : 1091
    },
    "minX" : 1750,
    "maxX" : 1849,
    "minY" : 1075,
    "maxY" : 1140,
    "prop" : {
      "x" : 1750,
      "y" : 1076,
      "width" : 37,
      "height" : 31
    },
    "textPosition" : {
      "x" : 1753,
      "y" : 1081
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1782,
          "y" : 1081
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1782,
          "y" : 1081
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 33728,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1790,
          "y" : 1102
        },
        "to" : {
          "x" : 1849,
          "y" : 1140
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 33731,
    "reactomeId" : 10227161,
    "displayName" : "phospho-RB1",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 2001,
      "y" : 1337
    },
    "minX" : 1506,
    "maxX" : 2087,
    "minY" : 1182,
    "maxY" : 1355,
    "prop" : {
      "x" : 1921,
      "y" : 1320,
      "width" : 160,
      "height" : 35
    },
    "textPosition" : {
      "x" : 1955,
      "y" : 1327
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 2081,
          "y" : 1320
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 2081,
          "y" : 1320
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 33728,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 1999,
          "y" : 1314
        },
        "to" : {
          "x" : 1988,
          "y" : 1182
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 1994,
          "y" : 1307
        },
        "b" : {
          "x" : 1999,
          "y" : 1314
        },
        "c" : {
          "x" : 2002,
          "y" : 1307
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 2002,
          "y" : 1307
        }
      }
    }, {
      "edgeId" : 33784,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1942,
          "y" : 1314
        },
        "to" : {
          "x" : 1506,
          "y" : 1189
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 33732,
    "reactomeId" : 113582,
    "displayName" : "ADP",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 2064,
      "y" : 1228
    },
    "minX" : 1988,
    "maxX" : 2085,
    "minY" : 1182,
    "maxY" : 1244,
    "prop" : {
      "x" : 2044,
      "y" : 1213,
      "width" : 40,
      "height" : 31
    },
    "textPosition" : {
      "x" : 2047,
      "y" : 1218
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 2079,
          "y" : 1218
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 2079,
          "y" : 1218
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 33728,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 2041,
          "y" : 1215
        },
        "to" : {
          "x" : 1988,
          "y" : 1182
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 2033,
          "y" : 1215
        },
        "b" : {
          "x" : 2041,
          "y" : 1215
        },
        "c" : {
          "x" : 2037,
          "y" : 1208
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 2037,
          "y" : 1208
        }
      }
    } ]
  }, {
    "id" : 33733,
    "reactomeId" : 10227267,
    "displayName" : "p-T172-CDK4,p-T177-CDK6:CCND:CDKN1A,CDKN1B,(CDKN1C); p-T172-CDK4,p-T177-CDK6:CCND; (p-T172-CDK4,p-T177-CDK6:CCND:p-Y88-CDKN1B)",
    "schemaClass" : "CandidateSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 1584,
      "y" : 851
    },
    "minX" : 1322,
    "maxX" : 2312,
    "minY" : 620,
    "maxY" : 1206,
    "prop" : {
      "x" : 1476,
      "y" : 808,
      "width" : 216,
      "height" : 87
    },
    "textPosition" : {
      "x" : 1478,
      "y" : 813
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "fgColor" : {
      "r" : 0,
      "g" : 0,
      "b" : 0
    },
    "connectors" : [ {
      "edgeId" : 33728,
      "type" : "CATALYST",
      "segments" : [ {
        "from" : {
          "x" : 1639,
          "y" : 901
        },
        "to" : {
          "x" : 1781,
          "y" : 1006
        }
      }, {
        "from" : {
          "x" : 1781,
          "y" : 1006
        },
        "to" : {
          "x" : 1885,
          "y" : 1126
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 1888,
          "y" : 1129
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1888,
          "y" : 1129
        }
      }
    }, {
      "edgeId" : 33795,
      "type" : "CATALYST",
      "segments" : [ {
        "from" : {
          "x" : 1530,
          "y" : 802
        },
        "to" : {
          "x" : 1330,
          "y" : 644
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 1326,
          "y" : 641
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1326,
          "y" : 641
        }
      }
    }, {
      "edgeId" : 33862,
      "type" : "INHIBITOR",
      "segments" : [ {
        "from" : {
          "x" : 1611,
          "y" : 901
        },
        "to" : {
          "x" : 1807,
          "y" : 1204
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 1804,
          "y" : 1206
        },
        "b" : {
          "x" : 1810,
          "y" : 1202
        },
        "c" : {
          "x" : 1807,
          "y" : 1204
        },
        "type" : "STOP",
        "centre" : {
          "x" : 1807,
          "y" : 1204
        }
      }
    }, {
      "edgeId" : 33853,
      "type" : "CATALYST",
      "segments" : [ {
        "from" : {
          "x" : 1698,
          "y" : 851
        },
        "to" : {
          "x" : 1978,
          "y" : 852
        }
      }, {
        "from" : {
          "x" : 1978,
          "y" : 852
        },
        "to" : {
          "x" : 2305,
          "y" : 626
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 2308,
          "y" : 624
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 2308,
          "y" : 624
        }
      }
    } ]
  }, {
    "id" : 33734,
    "reactomeId" : 10227276,
    "displayName" : "p-T172-CDK4:CCND:CDK4 inhibitors",
    "schemaClass" : "DefinedSet",
    "renderableClass" : "EntitySetDrug",
    "position" : {
      "x" : 1967,
      "y" : 1076
    },
    "minX" : 1896,
    "maxX" : 2038,
    "minY" : 1055,
    "maxY" : 1136,
    "prop" : {
      "x" : 1896,
      "y" : 1055,
      "width" : 142,
      "height" : 42
    },
    "textPosition" : {
      "x" : 1902,
      "y" : 1058
    },
    "bgColor" : {
      "r" : 184,
      "g" : 154,
      "b" : 230
    },
    "fgColor" : {
      "r" : 161,
      "g" : 1,
      "b" : 2
    },
    "connectors" : [ {
      "edgeId" : 33728,
      "type" : "INHIBITOR",
      "segments" : [ {
        "from" : {
          "x" : 1942,
          "y" : 1103
        },
        "to" : {
          "x" : 1903,
          "y" : 1133
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 1901,
          "y" : 1130
        },
        "b" : {
          "x" : 1905,
          "y" : 1136
        },
        "c" : {
          "x" : 1903,
          "y" : 1133
        },
        "type" : "STOP",
        "centre" : {
          "x" : 1903,
          "y" : 1133
        }
      }
    }, {
      "edgeId" : 33867,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 33735,
    "reactomeId" : 10227284,
    "displayName" : "p-T177-CDK6:CCND:CDK6 inhibitors",
    "schemaClass" : "DefinedSet",
    "renderableClass" : "EntitySetDrug",
    "position" : {
      "x" : 2057,
      "y" : 975
    },
    "minX" : 1905,
    "maxX" : 2128,
    "minY" : 958,
    "maxY" : 1142,
    "prop" : {
      "x" : 1986,
      "y" : 958,
      "width" : 142,
      "height" : 35
    },
    "textPosition" : {
      "x" : 1992,
      "y" : 958
    },
    "bgColor" : {
      "r" : 184,
      "g" : 154,
      "b" : 230
    },
    "fgColor" : {
      "r" : 161,
      "g" : 1,
      "b" : 2
    },
    "connectors" : [ {
      "edgeId" : 33728,
      "type" : "INHIBITOR",
      "segments" : [ {
        "from" : {
          "x" : 2057,
          "y" : 999
        },
        "to" : {
          "x" : 2057,
          "y" : 1141
        }
      }, {
        "from" : {
          "x" : 2057,
          "y" : 1141
        },
        "to" : {
          "x" : 1905,
          "y" : 1138
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 1905,
          "y" : 1142
        },
        "b" : {
          "x" : 1905,
          "y" : 1134
        },
        "c" : {
          "x" : 1905,
          "y" : 1138
        },
        "type" : "STOP",
        "centre" : {
          "x" : 1905,
          "y" : 1138
        }
      }
    }, {
      "edgeId" : 33870,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 33737,
    "reactomeId" : 10227122,
    "displayName" : "CCNE",
    "schemaClass" : "DefinedSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 663,
      "y" : 1720
    },
    "minX" : 607,
    "maxX" : 691,
    "minY" : 1699,
    "maxY" : 1731,
    "prop" : {
      "x" : 635,
      "y" : 1709,
      "width" : 56,
      "height" : 22
    },
    "textPosition" : {
      "x" : 642,
      "y" : 1709
    },
    "connectors" : [ {
      "edgeId" : 33736,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 629,
          "y" : 1709
        },
        "to" : {
          "x" : 607,
          "y" : 1699
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 33738,
    "reactomeId" : 10227116,
    "displayName" : "CDK2",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 556,
      "y" : 1720
    },
    "minX" : 531,
    "maxX" : 607,
    "minY" : 1699,
    "maxY" : 1731,
    "prop" : {
      "x" : 531,
      "y" : 1709,
      "width" : 50,
      "height" : 22
    },
    "textPosition" : {
      "x" : 536,
      "y" : 1709
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 581,
          "y" : 1709
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 581,
          "y" : 1709
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 33736,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 584,
          "y" : 1709
        },
        "to" : {
          "x" : 607,
          "y" : 1699
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 33739,
    "reactomeId" : 10227124,
    "displayName" : "CCNE:CDK2",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 619,
      "y" : 1627
    },
    "minX" : 575,
    "maxX" : 670,
    "minY" : 1606,
    "maxY" : 1642,
    "prop" : {
      "x" : 575,
      "y" : 1612,
      "width" : 89,
      "height" : 30
    },
    "textPosition" : {
      "x" : 581,
      "y" : 1621
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 664,
          "y" : 1612
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 664,
          "y" : 1612
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 33736,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 33740,
      "type" : "INPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 33741,
    "reactomeId" : 10227130,
    "displayName" : "CCNE:CDK2",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 1137,
      "y" : 1626
    },
    "minX" : 920,
    "maxX" : 1189,
    "minY" : 1287,
    "maxY" : 1839,
    "prop" : {
      "x" : 1092,
      "y" : 1613,
      "width" : 91,
      "height" : 27
    },
    "textPosition" : {
      "x" : 1099,
      "y" : 1619
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1183,
          "y" : 1613
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1183,
          "y" : 1613
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 33740,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 33742,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1134,
          "y" : 1610
        },
        "to" : {
          "x" : 1070,
          "y" : 1287
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 33759,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1089,
          "y" : 1637
        },
        "to" : {
          "x" : 920,
          "y" : 1682
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 33765,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 1134,
          "y" : 1643
        },
        "to" : {
          "x" : 1099,
          "y" : 1839
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 1137,
          "y" : 1651
        },
        "b" : {
          "x" : 1134,
          "y" : 1643
        },
        "c" : {
          "x" : 1129,
          "y" : 1649
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 1129,
          "y" : 1649
        }
      }
    } ]
  }, {
    "id" : 33743,
    "reactomeId" : 10227292,
    "displayName" : "CDKN1A,CDKN1B",
    "schemaClass" : "DefinedSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 994,
      "y" : 1287
    },
    "minX" : 963,
    "maxX" : 1103,
    "minY" : 1248,
    "maxY" : 1303,
    "prop" : {
      "x" : 963,
      "y" : 1271,
      "width" : 63,
      "height" : 32
    },
    "textPosition" : {
      "x" : 964,
      "y" : 1270
    },
    "connectors" : [ {
      "edgeId" : 33742,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1032,
          "y" : 1287
        },
        "to" : {
          "x" : 1070,
          "y" : 1287
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 33742,
      "type" : "CATALYST",
      "segments" : [ {
        "from" : {
          "x" : 1032,
          "y" : 1275
        },
        "to" : {
          "x" : 1098,
          "y" : 1248
        }
      }, {
        "from" : {
          "x" : 1098,
          "y" : 1248
        },
        "to" : {
          "x" : 1099,
          "y" : 1271
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 1099,
          "y" : 1275
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1099,
          "y" : 1275
        }
      }
    } ]
  }, {
    "id" : 33744,
    "reactomeId" : 10227294,
    "displayName" : "Cyclin E:CDK2:CDKN1A,CDKN1B",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 1193,
      "y" : 1289
    },
    "minX" : 1135,
    "maxX" : 1257,
    "minY" : 1265,
    "maxY" : 1307,
    "prop" : {
      "x" : 1135,
      "y" : 1271,
      "width" : 116,
      "height" : 36
    },
    "textPosition" : {
      "x" : 1138,
      "y" : 1272
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1251,
          "y" : 1271
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1251,
          "y" : 1271
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 33742,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 33746,
    "reactomeId" : 29358,
    "displayName" : "ATP",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 1411,
      "y" : 1440
    },
    "minX" : 1391,
    "maxX" : 1433,
    "minY" : 1391,
    "maxY" : 1452,
    "prop" : {
      "x" : 1391,
      "y" : 1428,
      "width" : 41,
      "height" : 24
    },
    "textPosition" : {
      "x" : 1396,
      "y" : 1429
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1427,
          "y" : 1433
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1427,
          "y" : 1433
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 33745,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1412,
          "y" : 1425
        },
        "to" : {
          "x" : 1418,
          "y" : 1391
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 33747,
    "reactomeId" : 10241190,
    "displayName" : "Cyclin E/A:p-T160-CDK2:CDKN1A,CDKN1B",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 1329,
      "y" : 1390
    },
    "minX" : 1271,
    "maxX" : 1462,
    "minY" : 1353,
    "maxY" : 1414,
    "prop" : {
      "x" : 1271,
      "y" : 1367,
      "width" : 116,
      "height" : 47
    },
    "textPosition" : {
      "x" : 1274,
      "y" : 1365
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1387,
          "y" : 1367
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1387,
          "y" : 1367
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 33745,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1390,
          "y" : 1390
        },
        "to" : {
          "x" : 1418,
          "y" : 1391
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 33745,
      "type" : "CATALYST",
      "segments" : [ {
        "from" : {
          "x" : 1390,
          "y" : 1370
        },
        "to" : {
          "x" : 1440,
          "y" : 1353
        }
      }, {
        "from" : {
          "x" : 1440,
          "y" : 1353
        },
        "to" : {
          "x" : 1456,
          "y" : 1377
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 1458,
          "y" : 1380
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1458,
          "y" : 1380
        }
      }
    } ]
  }, {
    "id" : 33748,
    "reactomeId" : 10241200,
    "displayName" : "Cyclin E/A:p-T160-CDK2:p-S130-CDKN1A,p-T187-CDKN1B",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 1627,
      "y" : 1442
    },
    "minX" : 1509,
    "maxX" : 1717,
    "minY" : 1389,
    "maxY" : 1493,
    "prop" : {
      "x" : 1544,
      "y" : 1418,
      "width" : 167,
      "height" : 48
    },
    "textPosition" : {
      "x" : 1544,
      "y" : 1417
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1711,
          "y" : 1418
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1711,
          "y" : 1418
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 33745,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 1573,
          "y" : 1415
        },
        "to" : {
          "x" : 1509,
          "y" : 1389
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 1565,
          "y" : 1416
        },
        "b" : {
          "x" : 1573,
          "y" : 1415
        },
        "c" : {
          "x" : 1568,
          "y" : 1409
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 1568,
          "y" : 1409
        }
      }
    }, {
      "edgeId" : 33750,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1643,
          "y" : 1469
        },
        "to" : {
          "x" : 1662,
          "y" : 1493
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 33749,
    "reactomeId" : 113582,
    "displayName" : "ADP",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 1504,
      "y" : 1439
    },
    "minX" : 1484,
    "maxX" : 1526,
    "minY" : 1389,
    "maxY" : 1451,
    "prop" : {
      "x" : 1484,
      "y" : 1427,
      "width" : 41,
      "height" : 24
    },
    "textPosition" : {
      "x" : 1488,
      "y" : 1428
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1520,
          "y" : 1432
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1520,
          "y" : 1432
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 33745,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 1505,
          "y" : 1424
        },
        "to" : {
          "x" : 1509,
          "y" : 1389
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 1502,
          "y" : 1417
        },
        "b" : {
          "x" : 1505,
          "y" : 1424
        },
        "c" : {
          "x" : 1510,
          "y" : 1418
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 1510,
          "y" : 1418
        }
      }
    } ]
  }, {
    "id" : 33751,
    "reactomeId" : 10241211,
    "displayName" : "CUL1:SKP1:SKP2:CKS1B",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 1570,
      "y" : 1518
    },
    "minX" : 1525,
    "maxX" : 1781,
    "minY" : 1493,
    "maxY" : 1600,
    "prop" : {
      "x" : 1525,
      "y" : 1500,
      "width" : 90,
      "height" : 36
    },
    "textPosition" : {
      "x" : 1529,
      "y" : 1501
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1615,
          "y" : 1500
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1615,
          "y" : 1500
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 33750,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1618,
          "y" : 1505
        },
        "to" : {
          "x" : 1662,
          "y" : 1493
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 33756,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 1618,
          "y" : 1535
        },
        "to" : {
          "x" : 1781,
          "y" : 1600
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 1626,
          "y" : 1534
        },
        "b" : {
          "x" : 1618,
          "y" : 1535
        },
        "c" : {
          "x" : 1623,
          "y" : 1541
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 1623,
          "y" : 1541
        }
      }
    } ]
  }, {
    "id" : 33752,
    "reactomeId" : 10241213,
    "displayName" : "Cyclin E/A:CDK2:p-S130-CDKN1A,p-T187-CDKN1B:CUL1:SKP1:SKP2:CKS1B",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 1809,
      "y" : 1459
    },
    "minX" : 1748,
    "maxX" : 1905,
    "minY" : 1416,
    "maxY" : 1534,
    "prop" : {
      "x" : 1748,
      "y" : 1422,
      "width" : 122,
      "height" : 75
    },
    "textPosition" : {
      "x" : 1749,
      "y" : 1420
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1870,
          "y" : 1422
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1870,
          "y" : 1422
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 33750,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 33753,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1824,
          "y" : 1500
        },
        "to" : {
          "x" : 1839,
          "y" : 1534
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 33753,
      "type" : "CATALYST",
      "segments" : [ {
        "from" : {
          "x" : 1873,
          "y" : 1459
        },
        "to" : {
          "x" : 1895,
          "y" : 1459
        }
      }, {
        "from" : {
          "x" : 1895,
          "y" : 1459
        },
        "to" : {
          "x" : 1901,
          "y" : 1518
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 1901,
          "y" : 1522
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1901,
          "y" : 1522
        }
      }
    } ]
  }, {
    "id" : 33754,
    "reactomeId" : 10226336,
    "displayName" : "Ub",
    "schemaClass" : "DefinedSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 1738,
      "y" : 1528
    },
    "minX" : 1707,
    "maxX" : 1839,
    "minY" : 1517,
    "maxY" : 1600,
    "prop" : {
      "x" : 1707,
      "y" : 1517,
      "width" : 63,
      "height" : 22
    },
    "textPosition" : {
      "x" : 1726,
      "y" : 1517
    },
    "connectors" : [ {
      "edgeId" : 33753,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1776,
          "y" : 1529
        },
        "to" : {
          "x" : 1839,
          "y" : 1534
        }
      } ],
      "stoichiometry" : {
        "value" : 3,
        "shape" : {
          "a" : {
            "x" : 1801,
            "y" : 1525
          },
          "b" : {
            "x" : 1813,
            "y" : 1537
          },
          "type" : "BOX",
          "empty" : true,
          "centre" : {
            "x" : 1807,
            "y" : 1531
          }
        }
      }
    }, {
      "edgeId" : 33756,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 1744,
          "y" : 1545
        },
        "to" : {
          "x" : 1781,
          "y" : 1600
        }
      } ],
      "stoichiometry" : {
        "value" : 3,
        "shape" : {
          "a" : {
            "x" : 1756,
            "y" : 1566
          },
          "b" : {
            "x" : 1768,
            "y" : 1578
          },
          "type" : "BOX",
          "empty" : true,
          "centre" : {
            "x" : 1762,
            "y" : 1572
          }
        }
      },
      "endShape" : {
        "a" : {
          "x" : 1751,
          "y" : 1549
        },
        "b" : {
          "x" : 1744,
          "y" : 1545
        },
        "c" : {
          "x" : 1745,
          "y" : 1553
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 1745,
          "y" : 1553
        }
      }
    } ]
  }, {
    "id" : 33755,
    "reactomeId" : 10241217,
    "displayName" : "Cyclin E/A:CDK2:p-S130-CDKN1A,p-T187-CDKN1B:CUL1:SKP1:SKP2:CKS1B:3xubiquitin",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 2017,
      "y" : 1535
    },
    "minX" : 1955,
    "maxX" : 2085,
    "minY" : 1490,
    "maxY" : 1574,
    "prop" : {
      "x" : 1955,
      "y" : 1496,
      "width" : 124,
      "height" : 78
    },
    "textPosition" : {
      "x" : 1957,
      "y" : 1497
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 2079,
          "y" : 1496
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 2079,
          "y" : 1496
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 33753,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 33756,
      "type" : "INPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 33757,
    "reactomeId" : 10226947,
    "displayName" : "CCNA:p-T160-CDK2,CCNE:p-T160-CDK2",
    "schemaClass" : "DefinedSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 1704,
      "y" : 1644
    },
    "minX" : 1654,
    "maxX" : 1781,
    "minY" : 1600,
    "maxY" : 1669,
    "prop" : {
      "x" : 1654,
      "y" : 1619,
      "width" : 100,
      "height" : 50
    },
    "textPosition" : {
      "x" : 1657,
      "y" : 1619
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "fgColor" : {
      "r" : 0,
      "g" : 0,
      "b" : 0
    },
    "connectors" : [ {
      "edgeId" : 33756,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 1747,
          "y" : 1613
        },
        "to" : {
          "x" : 1781,
          "y" : 1600
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 1752,
          "y" : 1607
        },
        "b" : {
          "x" : 1747,
          "y" : 1613
        },
        "c" : {
          "x" : 1755,
          "y" : 1614
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 1755,
          "y" : 1614
        }
      }
    } ]
  }, {
    "id" : 33758,
    "reactomeId" : 10226583,
    "displayName" : "26S proteasome",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 1836,
      "y" : 1680
    },
    "minX" : 1780,
    "maxX" : 1899,
    "minY" : 1631,
    "maxY" : 1691,
    "prop" : {
      "x" : 1780,
      "y" : 1669,
      "width" : 113,
      "height" : 22
    },
    "textPosition" : {
      "x" : 1780,
      "y" : 1670
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1893,
          "y" : 1669
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1893,
          "y" : 1669
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 33756,
      "type" : "CATALYST",
      "segments" : [ {
        "from" : {
          "x" : 1833,
          "y" : 1666
        },
        "to" : {
          "x" : 1825,
          "y" : 1638
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 1824,
          "y" : 1635
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1824,
          "y" : 1635
        }
      }
    } ]
  }, {
    "id" : 33760,
    "reactomeId" : 29358,
    "displayName" : "ATP",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 876,
      "y" : 1683
    },
    "minX" : 856,
    "maxX" : 920,
    "minY" : 1667,
    "maxY" : 1698,
    "prop" : {
      "x" : 856,
      "y" : 1668,
      "width" : 40,
      "height" : 30
    },
    "textPosition" : {
      "x" : 860,
      "y" : 1672
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 891,
          "y" : 1673
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 891,
          "y" : 1673
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 33759,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 899,
          "y" : 1682
        },
        "to" : {
          "x" : 920,
          "y" : 1682
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 33761,
    "reactomeId" : 113582,
    "displayName" : "ADP",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 868,
      "y" : 1755
    },
    "minX" : 848,
    "maxX" : 920,
    "minY" : 1739,
    "maxY" : 1770,
    "prop" : {
      "x" : 848,
      "y" : 1740,
      "width" : 41,
      "height" : 30
    },
    "textPosition" : {
      "x" : 852,
      "y" : 1744
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 884,
          "y" : 1745
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 884,
          "y" : 1745
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 33759,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 892,
          "y" : 1748
        },
        "to" : {
          "x" : 920,
          "y" : 1739
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 897,
          "y" : 1742
        },
        "b" : {
          "x" : 892,
          "y" : 1748
        },
        "c" : {
          "x" : 900,
          "y" : 1750
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 900,
          "y" : 1750
        }
      }
    } ]
  }, {
    "id" : 33762,
    "reactomeId" : 10227135,
    "displayName" : "Cyclin E:p-CDK2",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 971,
      "y" : 1794
    },
    "minX" : 912,
    "maxX" : 1037,
    "minY" : 1739,
    "maxY" : 1844,
    "prop" : {
      "x" : 912,
      "y" : 1781,
      "width" : 119,
      "height" : 26
    },
    "textPosition" : {
      "x" : 920,
      "y" : 1786
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1031,
          "y" : 1781
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1031,
          "y" : 1781
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 33759,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 958,
          "y" : 1778
        },
        "to" : {
          "x" : 920,
          "y" : 1739
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 950,
          "y" : 1776
        },
        "b" : {
          "x" : 958,
          "y" : 1778
        },
        "c" : {
          "x" : 956,
          "y" : 1770
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 956,
          "y" : 1770
        }
      }
    }, {
      "edgeId" : 33765,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 985,
          "y" : 1810
        },
        "to" : {
          "x" : 1026,
          "y" : 1844
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 33763,
    "reactomeId" : 10227139,
    "displayName" : "WEE1",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 975,
      "y" : 1710
    },
    "minX" : 928,
    "maxX" : 1003,
    "minY" : 1693,
    "maxY" : 1721,
    "prop" : {
      "x" : 953,
      "y" : 1699,
      "width" : 44,
      "height" : 22
    },
    "textPosition" : {
      "x" : 953,
      "y" : 1699
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 997,
          "y" : 1699
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 997,
          "y" : 1699
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 33759,
      "type" : "CATALYST",
      "segments" : [ {
        "from" : {
          "x" : 950,
          "y" : 1710
        },
        "to" : {
          "x" : 936,
          "y" : 1710
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 932,
          "y" : 1711
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 932,
          "y" : 1711
        }
      }
    } ]
  }, {
    "id" : 33764,
    "reactomeId" : 10227144,
    "displayName" : "CABLES1",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 794,
      "y" : 1715
    },
    "minX" : 765,
    "maxX" : 911,
    "minY" : 1698,
    "maxY" : 1726,
    "prop" : {
      "x" : 765,
      "y" : 1704,
      "width" : 59,
      "height" : 22
    },
    "textPosition" : {
      "x" : 767,
      "y" : 1698
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 824,
          "y" : 1704
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 824,
          "y" : 1704
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 33759,
      "type" : "ACTIVATOR",
      "segments" : [ {
        "from" : {
          "x" : 827,
          "y" : 1714
        },
        "to" : {
          "x" : 911,
          "y" : 1711
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 904,
          "y" : 1715
        },
        "b" : {
          "x" : 911,
          "y" : 1711
        },
        "c" : {
          "x" : 904,
          "y" : 1707
        },
        "type" : "ARROW",
        "empty" : true,
        "centre" : {
          "x" : 904,
          "y" : 1707
        }
      }
    } ]
  }, {
    "id" : 33766,
    "reactomeId" : 113518,
    "displayName" : "H2O",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 999,
      "y" : 1878
    },
    "minX" : 978,
    "maxX" : 1026,
    "minY" : 1844,
    "maxY" : 1893,
    "prop" : {
      "x" : 978,
      "y" : 1863,
      "width" : 43,
      "height" : 30
    },
    "textPosition" : {
      "x" : 982,
      "y" : 1867
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1016,
          "y" : 1868
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1016,
          "y" : 1868
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 33765,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1010,
          "y" : 1860
        },
        "to" : {
          "x" : 1026,
          "y" : 1844
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ],
    "trivial" : true
  }, {
    "id" : 33767,
    "reactomeId" : 113550,
    "displayName" : "Pi",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 1122,
      "y" : 1887
    },
    "minX" : 1099,
    "maxX" : 1138,
    "minY" : 1839,
    "maxY" : 1900,
    "prop" : {
      "x" : 1107,
      "y" : 1874,
      "width" : 30,
      "height" : 26
    },
    "textPosition" : {
      "x" : 1112,
      "y" : 1876
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1132,
          "y" : 1879
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1132,
          "y" : 1879
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 33765,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 1115,
          "y" : 1871
        },
        "to" : {
          "x" : 1099,
          "y" : 1839
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 1108,
          "y" : 1867
        },
        "b" : {
          "x" : 1115,
          "y" : 1871
        },
        "c" : {
          "x" : 1115,
          "y" : 1863
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 1115,
          "y" : 1863
        }
      }
    } ]
  }, {
    "id" : 33768,
    "reactomeId" : 10227151,
    "displayName" : "CDC25A",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 936,
      "y" : 1986
    },
    "minX" : 906,
    "maxX" : 1069,
    "minY" : 1852,
    "maxY" : 1997,
    "prop" : {
      "x" : 906,
      "y" : 1975,
      "width" : 60,
      "height" : 22
    },
    "textPosition" : {
      "x" : 907,
      "y" : 1975
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 966,
          "y" : 1975
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 966,
          "y" : 1975
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 33765,
      "type" : "CATALYST",
      "segments" : [ {
        "from" : {
          "x" : 951,
          "y" : 1972
        },
        "to" : {
          "x" : 1063,
          "y" : 1894
        }
      }, {
        "from" : {
          "x" : 1063,
          "y" : 1894
        },
        "to" : {
          "x" : 1064,
          "y" : 1860
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 1065,
          "y" : 1856
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1065,
          "y" : 1856
        }
      }
    } ]
  }, {
    "id" : 33770,
    "reactomeId" : 10241307,
    "displayName" : "CCNE:p-T160-CDK2:hypophosphorylated RB1",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 1582,
      "y" : 1278
    },
    "minX" : 1506,
    "maxX" : 1776,
    "minY" : 1253,
    "maxY" : 1311,
    "prop" : {
      "x" : 1506,
      "y" : 1259,
      "width" : 153,
      "height" : 39
    },
    "textPosition" : {
      "x" : 1512,
      "y" : 1249
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1659,
          "y" : 1259
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1659,
          "y" : 1259
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 33769,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1662,
          "y" : 1288
        },
        "to" : {
          "x" : 1705,
          "y" : 1295
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 33769,
      "type" : "CATALYST",
      "segments" : [ {
        "from" : {
          "x" : 1662,
          "y" : 1275
        },
        "to" : {
          "x" : 1709,
          "y" : 1274
        }
      }, {
        "from" : {
          "x" : 1709,
          "y" : 1274
        },
        "to" : {
          "x" : 1769,
          "y" : 1305
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 1772,
          "y" : 1307
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1772,
          "y" : 1307
        }
      }
    }, {
      "edgeId" : 33784,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 33771,
    "reactomeId" : 29358,
    "displayName" : "ATP",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 1644,
      "y" : 1330
    },
    "minX" : 1625,
    "maxX" : 1705,
    "minY" : 1295,
    "maxY" : 1342,
    "prop" : {
      "x" : 1625,
      "y" : 1319,
      "width" : 39,
      "height" : 23
    },
    "textPosition" : {
      "x" : 1629,
      "y" : 1320
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1659,
          "y" : 1324
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1659,
          "y" : 1324
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 33769,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1664,
          "y" : 1316
        },
        "to" : {
          "x" : 1705,
          "y" : 1295
        }
      } ],
      "stoichiometry" : {
        "value" : 14,
        "shape" : {
          "a" : {
            "x" : 1678,
            "y" : 1299
          },
          "b" : {
            "x" : 1690,
            "y" : 1311
          },
          "type" : "BOX",
          "empty" : true,
          "centre" : {
            "x" : 1684,
            "y" : 1305
          }
        }
      }
    } ]
  }, {
    "id" : 33772,
    "reactomeId" : 10234550,
    "displayName" : "phospho-RB1",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 1975,
      "y" : 1430
    },
    "minX" : 1837,
    "maxX" : 2134,
    "minY" : 1324,
    "maxY" : 1451,
    "prop" : {
      "x" : 1889,
      "y" : 1410,
      "width" : 172,
      "height" : 41
    },
    "textPosition" : {
      "x" : 1929,
      "y" : 1420
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 2061,
          "y" : 1410
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 2061,
          "y" : 1410
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 33769,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 1948,
          "y" : 1407
        },
        "to" : {
          "x" : 1837,
          "y" : 1324
        }
      } ],
      "stoichiometry" : {
        "value" : 14,
        "shape" : {
          "a" : {
            "x" : 1886,
            "y" : 1359
          },
          "b" : {
            "x" : 1898,
            "y" : 1371
          },
          "type" : "BOX",
          "empty" : true,
          "centre" : {
            "x" : 1892,
            "y" : 1365
          }
        }
      },
      "endShape" : {
        "a" : {
          "x" : 1940,
          "y" : 1406
        },
        "b" : {
          "x" : 1948,
          "y" : 1407
        },
        "c" : {
          "x" : 1945,
          "y" : 1400
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 1945,
          "y" : 1400
        }
      }
    }, {
      "edgeId" : 33779,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 2064,
          "y" : 1437
        },
        "to" : {
          "x" : 2134,
          "y" : 1444
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 33773,
    "reactomeId" : 113582,
    "displayName" : "ADP",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 1843,
      "y" : 1382
    },
    "minX" : 1821,
    "maxX" : 1866,
    "minY" : 1324,
    "maxY" : 1393,
    "prop" : {
      "x" : 1821,
      "y" : 1371,
      "width" : 44,
      "height" : 22
    },
    "textPosition" : {
      "x" : 1826,
      "y" : 1371
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1860,
          "y" : 1376
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1860,
          "y" : 1376
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 33769,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 1841,
          "y" : 1368
        },
        "to" : {
          "x" : 1837,
          "y" : 1324
        }
      } ],
      "stoichiometry" : {
        "value" : 14,
        "shape" : {
          "a" : {
            "x" : 1833,
            "y" : 1340
          },
          "b" : {
            "x" : 1845,
            "y" : 1352
          },
          "type" : "BOX",
          "empty" : true,
          "centre" : {
            "x" : 1839,
            "y" : 1346
          }
        }
      },
      "endShape" : {
        "a" : {
          "x" : 1836,
          "y" : 1361
        },
        "b" : {
          "x" : 1841,
          "y" : 1368
        },
        "c" : {
          "x" : 1844,
          "y" : 1361
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 1844,
          "y" : 1361
        }
      }
    } ]
  }, {
    "id" : 33774,
    "reactomeId" : 10226945,
    "displayName" : "Cyclin E:p-T160-CDK2",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 1447,
      "y" : 1146
    },
    "minX" : 1392,
    "maxX" : 1837,
    "minY" : 1122,
    "maxY" : 1365,
    "prop" : {
      "x" : 1392,
      "y" : 1128,
      "width" : 111,
      "height" : 36
    },
    "textPosition" : {
      "x" : 1394,
      "y" : 1129
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1503,
          "y" : 1128
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1503,
          "y" : 1128
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 33862,
      "type" : "INHIBITOR",
      "segments" : [ {
        "from" : {
          "x" : 1500,
          "y" : 1167
        },
        "to" : {
          "x" : 1727,
          "y" : 1240
        }
      }, {
        "from" : {
          "x" : 1727,
          "y" : 1240
        },
        "to" : {
          "x" : 1803,
          "y" : 1215
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 1802,
          "y" : 1211
        },
        "b" : {
          "x" : 1804,
          "y" : 1219
        },
        "c" : {
          "x" : 1803,
          "y" : 1215
        },
        "type" : "STOP",
        "centre" : {
          "x" : 1803,
          "y" : 1215
        }
      }
    }, {
      "edgeId" : 33769,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 1450,
          "y" : 1167
        },
        "to" : {
          "x" : 1482,
          "y" : 1308
        }
      }, {
        "from" : {
          "x" : 1482,
          "y" : 1308
        },
        "to" : {
          "x" : 1581,
          "y" : 1365
        }
      }, {
        "from" : {
          "x" : 1581,
          "y" : 1365
        },
        "to" : {
          "x" : 1837,
          "y" : 1324
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 1455,
          "y" : 1173
        },
        "b" : {
          "x" : 1450,
          "y" : 1167
        },
        "c" : {
          "x" : 1448,
          "y" : 1175
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 1448,
          "y" : 1175
        }
      }
    }, {
      "edgeId" : 33784,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1471,
          "y" : 1167
        },
        "to" : {
          "x" : 1506,
          "y" : 1189
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 33776,
    "reactomeId" : 10226923,
    "displayName" : "RNA primer-DNA primer:origin duplex",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 2173,
      "y" : 1811
    },
    "minX" : 2106,
    "maxX" : 2246,
    "minY" : 1787,
    "maxY" : 1829,
    "prop" : {
      "x" : 2106,
      "y" : 1793,
      "width" : 134,
      "height" : 36
    },
    "textPosition" : {
      "x" : 2107,
      "y" : 1794
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 2240,
          "y" : 1793
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 2240,
          "y" : 1793
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 33775,
      "type" : "INPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 33777,
    "reactomeId" : 113656,
    "displayName" : "RNA primer-DNA primer:origin duplex with DNA damage",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 2312,
      "y" : 1740
    },
    "minX" : 2134,
    "maxX" : 2384,
    "minY" : 1444,
    "maxY" : 1807,
    "prop" : {
      "x" : 2246,
      "y" : 1715,
      "width" : 132,
      "height" : 50
    },
    "textPosition" : {
      "x" : 2244,
      "y" : 1716
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 2378,
          "y" : 1715
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 2378,
          "y" : 1715
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 33775,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 2306,
          "y" : 1768
        },
        "to" : {
          "x" : 2298,
          "y" : 1807
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 2309,
          "y" : 1776
        },
        "b" : {
          "x" : 2306,
          "y" : 1768
        },
        "c" : {
          "x" : 2301,
          "y" : 1774
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 2301,
          "y" : 1774
        }
      }
    }, {
      "edgeId" : 33779,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 2296,
          "y" : 1712
        },
        "to" : {
          "x" : 2134,
          "y" : 1444
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 33778,
    "reactomeId" : 10226606,
    "displayName" : "DNA polymerase alpha:primase",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 2337,
      "y" : 1886
    },
    "minX" : 2282,
    "maxX" : 2398,
    "minY" : 1807,
    "maxY" : 1904,
    "prop" : {
      "x" : 2282,
      "y" : 1868,
      "width" : 110,
      "height" : 36
    },
    "textPosition" : {
      "x" : 2280,
      "y" : 1869
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 2392,
          "y" : 1868
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 2392,
          "y" : 1868
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 33775,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 2328,
          "y" : 1865
        },
        "to" : {
          "x" : 2298,
          "y" : 1807
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 2321,
          "y" : 1861
        },
        "b" : {
          "x" : 2328,
          "y" : 1865
        },
        "c" : {
          "x" : 2328,
          "y" : 1857
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 2328,
          "y" : 1857
        }
      }
    } ]
  }, {
    "id" : 33780,
    "reactomeId" : 113518,
    "displayName" : "H2O",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 2115,
      "y" : 1517
    },
    "minX" : 2096,
    "maxX" : 2136,
    "minY" : 1444,
    "maxY" : 1530,
    "prop" : {
      "x" : 2096,
      "y" : 1505,
      "width" : 39,
      "height" : 25
    },
    "textPosition" : {
      "x" : 2098,
      "y" : 1507
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 2130,
          "y" : 1510
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 2130,
          "y" : 1510
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 33779,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 2118,
          "y" : 1502
        },
        "to" : {
          "x" : 2134,
          "y" : 1444
        }
      } ],
      "stoichiometry" : {
        "value" : 14,
        "shape" : {
          "a" : {
            "x" : 2120,
            "y" : 1467
          },
          "b" : {
            "x" : 2132,
            "y" : 1479
          },
          "type" : "BOX",
          "empty" : true,
          "centre" : {
            "x" : 2126,
            "y" : 1473
          }
        }
      }
    } ],
    "trivial" : true
  }, {
    "id" : 33781,
    "reactomeId" : 10234552,
    "displayName" : "RB1:RNA primer-DNA primer:origin duplex with DNA damage",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 2301,
      "y" : 1460
    },
    "minX" : 2221,
    "maxX" : 2366,
    "minY" : 1422,
    "maxY" : 1492,
    "prop" : {
      "x" : 2242,
      "y" : 1428,
      "width" : 118,
      "height" : 64
    },
    "textPosition" : {
      "x" : 2241,
      "y" : 1429
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 2360,
          "y" : 1428
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 2360,
          "y" : 1428
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 33779,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 2239,
          "y" : 1453
        },
        "to" : {
          "x" : 2221,
          "y" : 1451
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 2232,
          "y" : 1456
        },
        "b" : {
          "x" : 2239,
          "y" : 1453
        },
        "c" : {
          "x" : 2233,
          "y" : 1448
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 2233,
          "y" : 1448
        }
      }
    } ]
  }, {
    "id" : 33782,
    "reactomeId" : 113550,
    "displayName" : "Pi",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 2243,
      "y" : 1530
    },
    "minX" : 2221,
    "maxX" : 2261,
    "minY" : 1451,
    "maxY" : 1542,
    "prop" : {
      "x" : 2226,
      "y" : 1519,
      "width" : 34,
      "height" : 23
    },
    "textPosition" : {
      "x" : 2233,
      "y" : 1520
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 2255,
          "y" : 1524
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 2255,
          "y" : 1524
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 33779,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 2239,
          "y" : 1516
        },
        "to" : {
          "x" : 2221,
          "y" : 1451
        }
      } ],
      "stoichiometry" : {
        "value" : 14,
        "shape" : {
          "a" : {
            "x" : 2224,
            "y" : 1477
          },
          "b" : {
            "x" : 2236,
            "y" : 1489
          },
          "type" : "BOX",
          "empty" : true,
          "centre" : {
            "x" : 2230,
            "y" : 1483
          }
        }
      },
      "endShape" : {
        "a" : {
          "x" : 2233,
          "y" : 1510
        },
        "b" : {
          "x" : 2239,
          "y" : 1516
        },
        "c" : {
          "x" : 2241,
          "y" : 1508
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 2241,
          "y" : 1508
        }
      }
    } ]
  }, {
    "id" : 33783,
    "reactomeId" : 10234578,
    "displayName" : "PP2A",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 2205,
      "y" : 1397
    },
    "minX" : 2185,
    "maxX" : 2232,
    "minY" : 1380,
    "maxY" : 1442,
    "prop" : {
      "x" : 2185,
      "y" : 1386,
      "width" : 41,
      "height" : 22
    },
    "textPosition" : {
      "x" : 2185,
      "y" : 1387
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 2226,
          "y" : 1386
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 2226,
          "y" : 1386
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 33779,
      "type" : "CATALYST",
      "segments" : [ {
        "from" : {
          "x" : 2204,
          "y" : 1411
        },
        "to" : {
          "x" : 2204,
          "y" : 1434
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 2204,
          "y" : 1438
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 2204,
          "y" : 1438
        }
      }
    } ]
  }, {
    "id" : 33786,
    "reactomeId" : 10240810,
    "displayName" : "INK4",
    "schemaClass" : "DefinedSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 142,
      "y" : 1000
    },
    "minX" : 120,
    "maxX" : 179,
    "minY" : 967,
    "maxY" : 1011,
    "prop" : {
      "x" : 120,
      "y" : 989,
      "width" : 45,
      "height" : 22
    },
    "textPosition" : {
      "x" : 125,
      "y" : 989
    },
    "connectors" : [ {
      "edgeId" : 33785,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 154,
          "y" : 983
        },
        "to" : {
          "x" : 179,
          "y" : 967
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 33787,
    "reactomeId" : 10240814,
    "displayName" : "CDK4,CDK6",
    "schemaClass" : "DefinedSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 161,
      "y" : 863
    },
    "minX" : 137,
    "maxX" : 205,
    "minY" : 827,
    "maxY" : 967,
    "prop" : {
      "x" : 137,
      "y" : 847,
      "width" : 49,
      "height" : 33
    },
    "textPosition" : {
      "x" : 139,
      "y" : 846
    },
    "connectors" : [ {
      "edgeId" : 33839,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 181,
          "y" : 841
        },
        "to" : {
          "x" : 205,
          "y" : 827
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 33785,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 163,
          "y" : 886
        },
        "to" : {
          "x" : 179,
          "y" : 967
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 33788,
    "reactomeId" : 10240816,
    "displayName" : "CDK4,CDK6:INK4",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 231,
      "y" : 919
    },
    "minX" : 188,
    "maxX" : 281,
    "minY" : 842,
    "maxY" : 938,
    "prop" : {
      "x" : 188,
      "y" : 901,
      "width" : 87,
      "height" : 37
    },
    "textPosition" : {
      "x" : 191,
      "y" : 903
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 275,
          "y" : 901
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 275,
          "y" : 901
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 33839,
      "type" : "INHIBITOR",
      "segments" : [ {
        "from" : {
          "x" : 230,
          "y" : 898
        },
        "to" : {
          "x" : 228,
          "y" : 842
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 224,
          "y" : 842
        },
        "b" : {
          "x" : 232,
          "y" : 842
        },
        "c" : {
          "x" : 228,
          "y" : 842
        },
        "type" : "STOP",
        "centre" : {
          "x" : 228,
          "y" : 842
        }
      }
    }, {
      "edgeId" : 33785,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 33790,
    "reactomeId" : 10241224,
    "displayName" : "CDKN1A",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 488,
      "y" : 1249
    },
    "minX" : 459,
    "maxX" : 523,
    "minY" : 1232,
    "maxY" : 1261,
    "prop" : {
      "x" : 459,
      "y" : 1238,
      "width" : 58,
      "height" : 23
    },
    "textPosition" : {
      "x" : 459,
      "y" : 1239
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 517,
          "y" : 1238
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 517,
          "y" : 1238
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 33789,
      "type" : "INPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 33791,
    "reactomeId" : 10227232,
    "displayName" : "CDKN1A",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 869,
      "y" : 1253
    },
    "minX" : 839,
    "maxX" : 906,
    "minY" : 1237,
    "maxY" : 1264,
    "prop" : {
      "x" : 839,
      "y" : 1243,
      "width" : 61,
      "height" : 21
    },
    "textPosition" : {
      "x" : 841,
      "y" : 1243
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 900,
          "y" : 1243
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 900,
          "y" : 1243
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 33789,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  } ],
  "edges" : [ {
    "id" : 33728,
    "reactomeId" : 10227286,
    "displayName" : "Cyclin D:CDK4/6 phosphorylates RB1 and prevents RB1 binding to E2F1/2/3:DP1/2 complexes",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 1896,
      "y" : 1138
    },
    "minX" : 1849,
    "maxX" : 1988,
    "minY" : 1132,
    "maxY" : 1182,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 1849,
        "y" : 1140
      },
      "to" : {
        "x" : 1896,
        "y" : 1138
      }
    }, {
      "from" : {
        "x" : 1896,
        "y" : 1138
      },
      "to" : {
        "x" : 1988,
        "y" : 1182
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 1890,
        "y" : 1132
      },
      "b" : {
        "x" : 1902,
        "y" : 1144
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 1896,
        "y" : 1138
      }
    },
    "inputs" : [ {
      "id" : 33729,
      "points" : [ {
        "x" : 1706,
        "y" : 1143
      } ]
    }, {
      "id" : 33730,
      "points" : [ {
        "x" : 1790,
        "y" : 1102
      } ]
    } ],
    "outputs" : [ {
      "id" : 33731,
      "points" : [ {
        "x" : 1999,
        "y" : 1314
      } ]
    }, {
      "id" : 33732,
      "points" : [ {
        "x" : 2041,
        "y" : 1215
      } ]
    } ],
    "catalysts" : [ {
      "id" : 33733,
      "points" : [ {
        "x" : 1639,
        "y" : 901
      }, {
        "x" : 1781,
        "y" : 1006
      } ]
    } ],
    "inhibitors" : [ {
      "id" : 33734,
      "points" : [ {
        "x" : 1942,
        "y" : 1103
      } ]
    }, {
      "id" : 33735,
      "points" : [ {
        "x" : 2057,
        "y" : 999
      }, {
        "x" : 2057,
        "y" : 1141
      } ]
    } ]
  }, {
    "id" : 33792,
    "reactomeId" : 10241188,
    "displayName" : "Translocation of p27 to the nucleoplasm",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 454,
      "y" : 1294
    },
    "minX" : 389,
    "maxX" : 841,
    "minY" : 1070,
    "maxY" : 1303,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 389,
        "y" : 1070
      },
      "to" : {
        "x" : 454,
        "y" : 1294
      }
    }, {
      "from" : {
        "x" : 454,
        "y" : 1294
      },
      "to" : {
        "x" : 841,
        "y" : 1303
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 834,
        "y" : 1307
      },
      "b" : {
        "x" : 841,
        "y" : 1303
      },
      "c" : {
        "x" : 834,
        "y" : 1299
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 834,
        "y" : 1299
      }
    },
    "reactionShape" : {
      "a" : {
        "x" : 448,
        "y" : 1288
      },
      "b" : {
        "x" : 460,
        "y" : 1300
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 454,
        "y" : 1294
      }
    },
    "inputs" : [ {
      "id" : 33793
    } ],
    "outputs" : [ {
      "id" : 33794
    } ]
  }, {
    "id" : 33858,
    "reactomeId" : 10267346,
    "displayName" : "Dephosphorylation of p107 (RBL1) by PP2A",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 2544,
      "y" : 650
    },
    "minX" : 2538,
    "maxX" : 2564,
    "minY" : 599,
    "maxY" : 688,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 2545,
        "y" : 688
      },
      "to" : {
        "x" : 2544,
        "y" : 650
      }
    }, {
      "from" : {
        "x" : 2544,
        "y" : 650
      },
      "to" : {
        "x" : 2564,
        "y" : 599
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 2538,
        "y" : 644
      },
      "b" : {
        "x" : 2550,
        "y" : 656
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 2544,
        "y" : 650
      }
    },
    "inputs" : [ {
      "id" : 33859,
      "points" : [ {
        "x" : 2538,
        "y" : 717
      } ],
      "stoichiometry" : 4
    }, {
      "id" : 33856,
      "points" : [ {
        "x" : 2476,
        "y" : 710
      } ]
    } ],
    "outputs" : [ {
      "id" : 33860,
      "points" : [ {
        "x" : 2154,
        "y" : 709
      }, {
        "x" : 2206,
        "y" : 782
      }, {
        "x" : 2580,
        "y" : 779
      } ]
    }, {
      "id" : 33861,
      "points" : [ {
        "x" : 2600,
        "y" : 561
      } ],
      "stoichiometry" : 4
    } ],
    "catalysts" : [ {
      "id" : 33819,
      "points" : [ {
        "x" : 950,
        "y" : 574
      }, {
        "x" : 885,
        "y" : 427
      }, {
        "x" : 2342,
        "y" : 405
      } ]
    } ]
  }, {
    "id" : 33795,
    "reactomeId" : 10265807,
    "displayName" : "Cyclin D:Cdk4/6 mediated phosphorylation of p130 (RBL2) and dissociation of phosphorylated p130 (RBL2) from DP1:E2F4/5 complex",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 1317,
      "y" : 634
    },
    "minX" : 1245,
    "maxX" : 1323,
    "minY" : 609,
    "maxY" : 665,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 1318,
        "y" : 609
      },
      "to" : {
        "x" : 1317,
        "y" : 634
      }
    }, {
      "from" : {
        "x" : 1317,
        "y" : 634
      },
      "to" : {
        "x" : 1245,
        "y" : 665
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 1311,
        "y" : 628
      },
      "b" : {
        "x" : 1323,
        "y" : 640
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 1317,
        "y" : 634
      }
    },
    "inputs" : [ {
      "id" : 33796,
      "points" : [ {
        "x" : 1350,
        "y" : 594
      } ],
      "stoichiometry" : 3
    }, {
      "id" : 33797,
      "points" : [ {
        "x" : 1265,
        "y" : 573
      } ]
    } ],
    "outputs" : [ {
      "id" : 33798,
      "points" : [ {
        "x" : 1237,
        "y" : 708
      } ]
    }, {
      "id" : 33799,
      "points" : [ {
        "x" : 1327,
        "y" : 724
      } ],
      "stoichiometry" : 3
    }, {
      "id" : 33800,
      "points" : [ {
        "x" : 1121,
        "y" : 663
      } ]
    } ],
    "catalysts" : [ {
      "id" : 33733,
      "points" : [ {
        "x" : 1530,
        "y" : 802
      } ]
    } ]
  }, {
    "id" : 33862,
    "reactomeId" : 10317072,
    "displayName" : "RB1 binds and inhibits E2F1/2/3:DP1/2 complexes",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 1812,
      "y" : 1212
    },
    "minX" : 1804,
    "maxX" : 1857,
    "minY" : 1176,
    "maxY" : 1230,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 1804,
        "y" : 1176
      },
      "to" : {
        "x" : 1812,
        "y" : 1212
      }
    }, {
      "from" : {
        "x" : 1812,
        "y" : 1212
      },
      "to" : {
        "x" : 1857,
        "y" : 1230
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 1849,
        "y" : 1231
      },
      "b" : {
        "x" : 1857,
        "y" : 1230
      },
      "c" : {
        "x" : 1852,
        "y" : 1224
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 1852,
        "y" : 1224
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 1812,
        "y" : 1212
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 1812,
        "y" : 1212
      }
    },
    "inputs" : [ {
      "id" : 33729,
      "points" : [ {
        "x" : 1706,
        "y" : 1156
      } ]
    }, {
      "id" : 33863,
      "points" : [ {
        "x" : 1850,
        "y" : 1181
      } ]
    } ],
    "outputs" : [ {
      "id" : 33864
    } ],
    "inhibitors" : [ {
      "id" : 33733,
      "points" : [ {
        "x" : 1611,
        "y" : 901
      } ]
    }, {
      "id" : 33774,
      "points" : [ {
        "x" : 1500,
        "y" : 1167
      }, {
        "x" : 1727,
        "y" : 1240
      } ]
    } ]
  }, {
    "id" : 33736,
    "reactomeId" : 10227126,
    "displayName" : "Formation of Cyclin E:Cdk2 complexes",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 611,
      "y" : 1671
    },
    "minX" : 605,
    "maxX" : 617,
    "minY" : 1645,
    "maxY" : 1699,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 607,
        "y" : 1699
      },
      "to" : {
        "x" : 611,
        "y" : 1671
      }
    }, {
      "from" : {
        "x" : 611,
        "y" : 1671
      },
      "to" : {
        "x" : 616,
        "y" : 1645
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 619,
        "y" : 1653
      },
      "b" : {
        "x" : 616,
        "y" : 1645
      },
      "c" : {
        "x" : 611,
        "y" : 1651
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 611,
        "y" : 1651
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 611,
        "y" : 1671
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 611,
        "y" : 1671
      }
    },
    "inputs" : [ {
      "id" : 33737,
      "points" : [ {
        "x" : 629,
        "y" : 1709
      } ]
    }, {
      "id" : 33738,
      "points" : [ {
        "x" : 584,
        "y" : 1709
      } ]
    } ],
    "outputs" : [ {
      "id" : 33739
    } ]
  }, {
    "id" : 33865,
    "reactomeId" : 10319792,
    "displayName" : "RB1 translocates to the nucleus",
    "schemaClass" : "BlackBoxEvent",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 1529,
      "y" : 1101
    },
    "minX" : 670,
    "maxX" : 1586,
    "minY" : 1088,
    "maxY" : 1208,
    "reactionType" : "omitted",
    "segments" : [ {
      "from" : {
        "x" : 670,
        "y" : 1208
      },
      "to" : {
        "x" : 1208,
        "y" : 1206
      }
    }, {
      "from" : {
        "x" : 1208,
        "y" : 1206
      },
      "to" : {
        "x" : 1318,
        "y" : 1088
      }
    }, {
      "from" : {
        "x" : 1318,
        "y" : 1088
      },
      "to" : {
        "x" : 1529,
        "y" : 1101
      }
    }, {
      "from" : {
        "x" : 1529,
        "y" : 1101
      },
      "to" : {
        "x" : 1586,
        "y" : 1121
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 1578,
        "y" : 1122
      },
      "b" : {
        "x" : 1586,
        "y" : 1121
      },
      "c" : {
        "x" : 1581,
        "y" : 1115
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 1581,
        "y" : 1115
      }
    },
    "reactionShape" : {
      "a" : {
        "x" : 1523,
        "y" : 1095
      },
      "b" : {
        "x" : 1535,
        "y" : 1107
      },
      "s" : "\\\\",
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 1529,
        "y" : 1101
      }
    },
    "inputs" : [ {
      "id" : 33866
    } ],
    "outputs" : [ {
      "id" : 33729
    } ]
  }, {
    "id" : 33801,
    "reactomeId" : 10267296,
    "displayName" : "p130 (RBL2) associates with MuvB to form DREAM complex",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 1383,
      "y" : 487
    },
    "minX" : 1308,
    "maxX" : 1485,
    "minY" : 481,
    "maxY" : 493,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 1308,
        "y" : 488
      },
      "to" : {
        "x" : 1383,
        "y" : 487
      }
    }, {
      "from" : {
        "x" : 1383,
        "y" : 487
      },
      "to" : {
        "x" : 1485,
        "y" : 487
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 1478,
        "y" : 491
      },
      "b" : {
        "x" : 1485,
        "y" : 487
      },
      "c" : {
        "x" : 1478,
        "y" : 483
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 1478,
        "y" : 483
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 1383,
        "y" : 487
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 1383,
        "y" : 487
      }
    },
    "inputs" : [ {
      "id" : 33797,
      "points" : [ {
        "x" : 1259,
        "y" : 531
      } ]
    }, {
      "id" : 33802,
      "points" : [ {
        "x" : 1277,
        "y" : 467
      } ]
    } ],
    "outputs" : [ {
      "id" : 33803
    } ]
  }, {
    "id" : 33867,
    "reactomeId" : 10322169,
    "displayName" : "CDK4 inhibitors bind CDK4",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 1950,
      "y" : 973
    },
    "minX" : 1925,
    "maxX" : 1963,
    "minY" : 967,
    "maxY" : 1049,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 1925,
        "y" : 984
      },
      "to" : {
        "x" : 1950,
        "y" : 973
      }
    }, {
      "from" : {
        "x" : 1950,
        "y" : 973
      },
      "to" : {
        "x" : 1963,
        "y" : 1049
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 1958,
        "y" : 1043
      },
      "b" : {
        "x" : 1963,
        "y" : 1049
      },
      "c" : {
        "x" : 1966,
        "y" : 1041
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 1966,
        "y" : 1041
      }
    },
    "reactionShape" : {
      "a" : {
        "x" : 1944,
        "y" : 967
      },
      "b" : {
        "x" : 1956,
        "y" : 979
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 1950,
        "y" : 973
      }
    },
    "inputs" : [ {
      "id" : 33868,
      "points" : [ {
        "x" : 1848,
        "y" : 966
      } ]
    }, {
      "id" : 33869,
      "points" : [ {
        "x" : 1901,
        "y" : 996
      } ]
    } ],
    "outputs" : [ {
      "id" : 33734
    } ]
  }, {
    "id" : 33804,
    "reactomeId" : 10267307,
    "displayName" : "Phosphorylation of LIN52 component of MuvB by DYRK1A",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 1069,
      "y" : 466
    },
    "minX" : 1041,
    "maxX" : 1097,
    "minY" : 460,
    "maxY" : 472,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 1041,
        "y" : 467
      },
      "to" : {
        "x" : 1069,
        "y" : 466
      }
    }, {
      "from" : {
        "x" : 1069,
        "y" : 466
      },
      "to" : {
        "x" : 1097,
        "y" : 466
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 1063,
        "y" : 460
      },
      "b" : {
        "x" : 1075,
        "y" : 472
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 1069,
        "y" : 466
      }
    },
    "inputs" : [ {
      "id" : 33805,
      "points" : [ {
        "x" : 1017,
        "y" : 479
      } ]
    }, {
      "id" : 33806,
      "points" : [ {
        "x" : 996,
        "y" : 457
      } ]
    } ],
    "outputs" : [ {
      "id" : 33802,
      "points" : [ {
        "x" : 1207,
        "y" : 457
      } ]
    }, {
      "id" : 33807,
      "points" : [ {
        "x" : 1113,
        "y" : 479
      } ]
    } ],
    "catalysts" : [ {
      "id" : 33808,
      "points" : [ {
        "x" : 1066,
        "y" : 415
      } ]
    } ]
  }, {
    "id" : 33740,
    "reactomeId" : 10236322,
    "displayName" : "Translocation of Cyclin E:Cdk2 complex to the nucleus",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 971,
      "y" : 1627
    },
    "minX" : 667,
    "maxX" : 1089,
    "minY" : 1621,
    "maxY" : 1633,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 667,
        "y" : 1627
      },
      "to" : {
        "x" : 971,
        "y" : 1627
      }
    }, {
      "from" : {
        "x" : 971,
        "y" : 1627
      },
      "to" : {
        "x" : 1089,
        "y" : 1626
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 1082,
        "y" : 1630
      },
      "b" : {
        "x" : 1089,
        "y" : 1626
      },
      "c" : {
        "x" : 1082,
        "y" : 1622
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 1082,
        "y" : 1622
      }
    },
    "reactionShape" : {
      "a" : {
        "x" : 965,
        "y" : 1621
      },
      "b" : {
        "x" : 977,
        "y" : 1633
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 971,
        "y" : 1627
      }
    },
    "inputs" : [ {
      "id" : 33739
    } ],
    "outputs" : [ {
      "id" : 33741
    } ]
  }, {
    "id" : 33870,
    "reactomeId" : 10322167,
    "displayName" : "CDK6 inhibitors bind CDK6",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 1971,
      "y" : 941
    },
    "minX" : 1919,
    "maxX" : 2012,
    "minY" : 934,
    "maxY" : 952,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 1919,
        "y" : 934
      },
      "to" : {
        "x" : 1971,
        "y" : 941
      }
    }, {
      "from" : {
        "x" : 1971,
        "y" : 941
      },
      "to" : {
        "x" : 2012,
        "y" : 952
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 2004,
        "y" : 954
      },
      "b" : {
        "x" : 2012,
        "y" : 952
      },
      "c" : {
        "x" : 2006,
        "y" : 946
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 2006,
        "y" : 946
      }
    },
    "reactionShape" : {
      "a" : {
        "x" : 1965,
        "y" : 935
      },
      "b" : {
        "x" : 1977,
        "y" : 947
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 1971,
        "y" : 941
      }
    },
    "inputs" : [ {
      "id" : 33871,
      "points" : [ {
        "x" : 1841,
        "y" : 901
      } ]
    }, {
      "id" : 33872,
      "points" : [ {
        "x" : 1955,
        "y" : 907
      } ]
    } ],
    "outputs" : [ {
      "id" : 33735
    } ]
  }, {
    "id" : 33742,
    "reactomeId" : 10227297,
    "displayName" : "Inactivation of Cyclin E:Cdk2 complexes by p27/p21",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 1099,
      "y" : 1287
    },
    "minX" : 1070,
    "maxX" : 1132,
    "minY" : 1281,
    "maxY" : 1293,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 1070,
        "y" : 1287
      },
      "to" : {
        "x" : 1099,
        "y" : 1287
      }
    }, {
      "from" : {
        "x" : 1099,
        "y" : 1287
      },
      "to" : {
        "x" : 1132,
        "y" : 1287
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 1125,
        "y" : 1291
      },
      "b" : {
        "x" : 1132,
        "y" : 1287
      },
      "c" : {
        "x" : 1125,
        "y" : 1283
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 1125,
        "y" : 1283
      }
    },
    "reactionShape" : {
      "a" : {
        "x" : 1093,
        "y" : 1281
      },
      "b" : {
        "x" : 1105,
        "y" : 1293
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 1099,
        "y" : 1287
      }
    },
    "inputs" : [ {
      "id" : 33741,
      "points" : [ {
        "x" : 1134,
        "y" : 1610
      } ]
    }, {
      "id" : 33743,
      "points" : [ {
        "x" : 1032,
        "y" : 1287
      } ]
    } ],
    "outputs" : [ {
      "id" : 33744
    } ],
    "catalysts" : [ {
      "id" : 33743,
      "points" : [ {
        "x" : 1032,
        "y" : 1275
      }, {
        "x" : 1098,
        "y" : 1248
      } ]
    } ]
  }, {
    "id" : 33745,
    "reactomeId" : 10241203,
    "displayName" : "Cyclin E/A:Cdk2-mediated  phosphorylation of p27/p21",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 1465,
      "y" : 1390
    },
    "minX" : 1418,
    "maxX" : 1509,
    "minY" : 1384,
    "maxY" : 1396,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 1418,
        "y" : 1391
      },
      "to" : {
        "x" : 1465,
        "y" : 1390
      }
    }, {
      "from" : {
        "x" : 1465,
        "y" : 1390
      },
      "to" : {
        "x" : 1509,
        "y" : 1389
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 1459,
        "y" : 1384
      },
      "b" : {
        "x" : 1471,
        "y" : 1396
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 1465,
        "y" : 1390
      }
    },
    "inputs" : [ {
      "id" : 33746,
      "points" : [ {
        "x" : 1412,
        "y" : 1425
      } ]
    }, {
      "id" : 33747,
      "points" : [ {
        "x" : 1390,
        "y" : 1390
      } ]
    } ],
    "outputs" : [ {
      "id" : 33748,
      "points" : [ {
        "x" : 1573,
        "y" : 1415
      } ]
    }, {
      "id" : 33749,
      "points" : [ {
        "x" : 1505,
        "y" : 1424
      } ]
    } ],
    "catalysts" : [ {
      "id" : 33747,
      "points" : [ {
        "x" : 1390,
        "y" : 1370
      }, {
        "x" : 1440,
        "y" : 1353
      } ]
    } ]
  }, {
    "id" : 33809,
    "reactomeId" : 10265827,
    "displayName" : "Recruitment of HDAC1 by p130 (RBL2)",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 1707,
      "y" : 540
    },
    "minX" : 1680,
    "maxX" : 1757,
    "minY" : 534,
    "maxY" : 547,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 1680,
        "y" : 535
      },
      "to" : {
        "x" : 1707,
        "y" : 540
      }
    }, {
      "from" : {
        "x" : 1707,
        "y" : 540
      },
      "to" : {
        "x" : 1757,
        "y" : 547
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 1750,
        "y" : 550
      },
      "b" : {
        "x" : 1757,
        "y" : 547
      },
      "c" : {
        "x" : 1751,
        "y" : 542
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 1751,
        "y" : 542
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 1707,
        "y" : 540
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 1707,
        "y" : 540
      }
    },
    "inputs" : [ {
      "id" : 33797,
      "points" : [ {
        "x" : 1303,
        "y" : 549
      } ]
    }, {
      "id" : 33810,
      "points" : [ {
        "x" : 1926,
        "y" : 433
      }, {
        "x" : 1789,
        "y" : 429
      } ]
    } ],
    "outputs" : [ {
      "id" : 33811
    } ]
  }, {
    "id" : 33812,
    "reactomeId" : 10265831,
    "displayName" : "Recruitment of HDAC1 by p107 (RBL1)",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 2111,
      "y" : 464
    },
    "minX" : 2067,
    "maxX" : 2143,
    "minY" : 452,
    "maxY" : 472,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 2067,
        "y" : 452
      },
      "to" : {
        "x" : 2111,
        "y" : 464
      }
    }, {
      "from" : {
        "x" : 2111,
        "y" : 464
      },
      "to" : {
        "x" : 2143,
        "y" : 472
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 2135,
        "y" : 474
      },
      "b" : {
        "x" : 2143,
        "y" : 472
      },
      "c" : {
        "x" : 2137,
        "y" : 466
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 2137,
        "y" : 466
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 2111,
        "y" : 464
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 2111,
        "y" : 464
      }
    },
    "inputs" : [ {
      "id" : 33813,
      "points" : [ {
        "x" : 2117,
        "y" : 442
      } ]
    }, {
      "id" : 33810,
      "points" : [ {
        "x" : 1983,
        "y" : 438
      } ]
    } ],
    "outputs" : [ {
      "id" : 33814
    } ]
  }, {
    "id" : 33750,
    "reactomeId" : 10241215,
    "displayName" : "Binding of phospho-p27/p21:Cdk2:Cyclin E/A to the SCF(Skp2):Cks1 complex",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 1701,
      "y" : 1493
    },
    "minX" : 1662,
    "maxX" : 1745,
    "minY" : 1478,
    "maxY" : 1499,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 1662,
        "y" : 1493
      },
      "to" : {
        "x" : 1701,
        "y" : 1493
      }
    }, {
      "from" : {
        "x" : 1701,
        "y" : 1493
      },
      "to" : {
        "x" : 1745,
        "y" : 1478
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 1740,
        "y" : 1484
      },
      "b" : {
        "x" : 1745,
        "y" : 1478
      },
      "c" : {
        "x" : 1737,
        "y" : 1476
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 1737,
        "y" : 1476
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 1701,
        "y" : 1493
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 1701,
        "y" : 1493
      }
    },
    "inputs" : [ {
      "id" : 33748,
      "points" : [ {
        "x" : 1643,
        "y" : 1469
      } ]
    }, {
      "id" : 33751,
      "points" : [ {
        "x" : 1618,
        "y" : 1505
      } ]
    } ],
    "outputs" : [ {
      "id" : 33752
    } ]
  }, {
    "id" : 33815,
    "reactomeId" : 10267348,
    "displayName" : "Dephosphorylation of p130 (RBL2) by PP2A",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 955,
      "y" : 641
    },
    "minX" : 922,
    "maxX" : 986,
    "minY" : 635,
    "maxY" : 647,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 986,
        "y" : 641
      },
      "to" : {
        "x" : 955,
        "y" : 641
      }
    }, {
      "from" : {
        "x" : 955,
        "y" : 641
      },
      "to" : {
        "x" : 922,
        "y" : 641
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 949,
        "y" : 635
      },
      "b" : {
        "x" : 961,
        "y" : 647
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 955,
        "y" : 641
      }
    },
    "inputs" : [ {
      "id" : 33816,
      "points" : [ {
        "x" : 1018,
        "y" : 616
      } ],
      "stoichiometry" : 3
    }, {
      "id" : 33800,
      "points" : [ {
        "x" : 1020,
        "y" : 650
      } ]
    } ],
    "outputs" : [ {
      "id" : 33817,
      "points" : [ {
        "x" : 861,
        "y" : 660
      } ]
    }, {
      "id" : 33818,
      "points" : [ {
        "x" : 871,
        "y" : 615
      } ],
      "stoichiometry" : 3
    } ],
    "catalysts" : [ {
      "id" : 33819,
      "points" : [ {
        "x" : 955,
        "y" : 602
      } ]
    } ]
  }, {
    "id" : 33753,
    "reactomeId" : 10241222,
    "displayName" : "Ubiquitination of phospho-p27/p21",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 1902,
      "y" : 1534
    },
    "minX" : 1839,
    "maxX" : 1952,
    "minY" : 1528,
    "maxY" : 1540,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 1839,
        "y" : 1534
      },
      "to" : {
        "x" : 1902,
        "y" : 1534
      }
    }, {
      "from" : {
        "x" : 1902,
        "y" : 1534
      },
      "to" : {
        "x" : 1952,
        "y" : 1534
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 1945,
        "y" : 1538
      },
      "b" : {
        "x" : 1952,
        "y" : 1534
      },
      "c" : {
        "x" : 1945,
        "y" : 1530
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 1945,
        "y" : 1530
      }
    },
    "reactionShape" : {
      "a" : {
        "x" : 1896,
        "y" : 1528
      },
      "b" : {
        "x" : 1908,
        "y" : 1540
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 1902,
        "y" : 1534
      }
    },
    "inputs" : [ {
      "id" : 33752,
      "points" : [ {
        "x" : 1824,
        "y" : 1500
      } ]
    }, {
      "id" : 33754,
      "points" : [ {
        "x" : 1776,
        "y" : 1529
      } ],
      "stoichiometry" : 3
    } ],
    "outputs" : [ {
      "id" : 33755
    } ],
    "catalysts" : [ {
      "id" : 33752,
      "points" : [ {
        "x" : 1873,
        "y" : 1459
      }, {
        "x" : 1895,
        "y" : 1459
      } ]
    } ]
  }, {
    "id" : 33756,
    "reactomeId" : 10241219,
    "displayName" : "Degradation of ubiquitinated p27/p21 by the 26S proteasome",
    "schemaClass" : "BlackBoxEvent",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 1821,
      "y" : 1623
    },
    "minX" : 1781,
    "maxX" : 1952,
    "minY" : 1562,
    "maxY" : 1629,
    "reactionType" : "omitted",
    "segments" : [ {
      "from" : {
        "x" : 1952,
        "y" : 1562
      },
      "to" : {
        "x" : 1821,
        "y" : 1623
      }
    }, {
      "from" : {
        "x" : 1821,
        "y" : 1623
      },
      "to" : {
        "x" : 1781,
        "y" : 1600
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 1815,
        "y" : 1617
      },
      "b" : {
        "x" : 1827,
        "y" : 1629
      },
      "s" : "\\\\",
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 1821,
        "y" : 1623
      }
    },
    "inputs" : [ {
      "id" : 33755
    } ],
    "outputs" : [ {
      "id" : 33751,
      "points" : [ {
        "x" : 1618,
        "y" : 1535
      } ]
    }, {
      "id" : 33757,
      "points" : [ {
        "x" : 1747,
        "y" : 1613
      } ]
    }, {
      "id" : 33754,
      "points" : [ {
        "x" : 1744,
        "y" : 1545
      } ],
      "stoichiometry" : 3
    } ],
    "catalysts" : [ {
      "id" : 33758,
      "points" : [ {
        "x" : 1833,
        "y" : 1666
      } ]
    } ]
  }, {
    "id" : 33820,
    "reactomeId" : 10267368,
    "displayName" : "p107 (RBL1) binds CyclinE/A:CDK2",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 1592,
      "y" : 1836
    },
    "minX" : 1546,
    "maxX" : 1651,
    "minY" : 1830,
    "maxY" : 1842,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 1546,
        "y" : 1836
      },
      "to" : {
        "x" : 1592,
        "y" : 1836
      }
    }, {
      "from" : {
        "x" : 1592,
        "y" : 1836
      },
      "to" : {
        "x" : 1651,
        "y" : 1836
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 1644,
        "y" : 1840
      },
      "b" : {
        "x" : 1651,
        "y" : 1836
      },
      "c" : {
        "x" : 1644,
        "y" : 1832
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 1644,
        "y" : 1832
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 1592,
        "y" : 1836
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 1592,
        "y" : 1836
      }
    },
    "inputs" : [ {
      "id" : 33821,
      "points" : [ {
        "x" : 1549,
        "y" : 1677
      } ]
    }, {
      "id" : 33822,
      "points" : [ {
        "x" : 1537,
        "y" : 1855
      } ]
    } ],
    "outputs" : [ {
      "id" : 33823
    } ]
  }, {
    "id" : 33759,
    "reactomeId" : 10227146,
    "displayName" : "Phosphorylation of Cyclin E:CDK2 complexes by WEE1",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 920,
      "y" : 1711
    },
    "minX" : 914,
    "maxX" : 926,
    "minY" : 1682,
    "maxY" : 1739,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 920,
        "y" : 1682
      },
      "to" : {
        "x" : 920,
        "y" : 1711
      }
    }, {
      "from" : {
        "x" : 920,
        "y" : 1711
      },
      "to" : {
        "x" : 920,
        "y" : 1739
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 914,
        "y" : 1705
      },
      "b" : {
        "x" : 926,
        "y" : 1717
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 920,
        "y" : 1711
      }
    },
    "inputs" : [ {
      "id" : 33760,
      "points" : [ {
        "x" : 899,
        "y" : 1682
      } ]
    }, {
      "id" : 33741,
      "points" : [ {
        "x" : 1089,
        "y" : 1637
      } ]
    } ],
    "outputs" : [ {
      "id" : 33761,
      "points" : [ {
        "x" : 892,
        "y" : 1748
      } ]
    }, {
      "id" : 33762,
      "points" : [ {
        "x" : 958,
        "y" : 1778
      } ]
    } ],
    "catalysts" : [ {
      "id" : 33763,
      "points" : [ {
        "x" : 950,
        "y" : 1710
      } ]
    } ],
    "activators" : [ {
      "id" : 33764,
      "points" : [ {
        "x" : 827,
        "y" : 1714
      } ]
    } ]
  }, {
    "id" : 33824,
    "reactomeId" : 10267364,
    "displayName" : "p107 (RBL1) in complex with E2F4:DP1/2 binds to cyclin E/A:CDK2",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 1424,
      "y" : 1802
    },
    "minX" : 1418,
    "maxX" : 1430,
    "minY" : 1759,
    "maxY" : 1835,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 1425,
        "y" : 1759
      },
      "to" : {
        "x" : 1424,
        "y" : 1802
      }
    }, {
      "from" : {
        "x" : 1424,
        "y" : 1802
      },
      "to" : {
        "x" : 1424,
        "y" : 1835
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 1420,
        "y" : 1828
      },
      "b" : {
        "x" : 1424,
        "y" : 1835
      },
      "c" : {
        "x" : 1428,
        "y" : 1828
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 1428,
        "y" : 1828
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 1424,
        "y" : 1802
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 1424,
        "y" : 1802
      }
    },
    "inputs" : [ {
      "id" : 33821,
      "points" : [ {
        "x" : 1534,
        "y" : 1677
      } ]
    }, {
      "id" : 33825,
      "points" : [ {
        "x" : 1335,
        "y" : 1739
      } ]
    } ],
    "outputs" : [ {
      "id" : 33826
    } ]
  }, {
    "id" : 33827,
    "reactomeId" : 10267360,
    "displayName" : "p130 (RBL2) binds Cyclin E/A:CDK2",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 1623,
      "y" : 1731
    },
    "minX" : 1595,
    "maxX" : 1662,
    "minY" : 1725,
    "maxY" : 1737,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 1595,
        "y" : 1731
      },
      "to" : {
        "x" : 1623,
        "y" : 1731
      }
    }, {
      "from" : {
        "x" : 1623,
        "y" : 1731
      },
      "to" : {
        "x" : 1662,
        "y" : 1733
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 1655,
        "y" : 1737
      },
      "b" : {
        "x" : 1662,
        "y" : 1733
      },
      "c" : {
        "x" : 1655,
        "y" : 1729
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 1655,
        "y" : 1729
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 1623,
        "y" : 1731
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 1623,
        "y" : 1731
      }
    },
    "inputs" : [ {
      "id" : 33821,
      "points" : [ {
        "x" : 1557,
        "y" : 1677
      } ]
    }, {
      "id" : 33828,
      "points" : [ {
        "x" : 1588,
        "y" : 1746
      } ]
    } ],
    "outputs" : [ {
      "id" : 33829
    } ]
  }, {
    "id" : 33765,
    "reactomeId" : 10227154,
    "displayName" : "Dephosphorylation of Cyclin E:Cdk2 complexes by Cdc25A",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 1065,
      "y" : 1844
    },
    "minX" : 1026,
    "maxX" : 1099,
    "minY" : 1838,
    "maxY" : 1850,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 1026,
        "y" : 1844
      },
      "to" : {
        "x" : 1065,
        "y" : 1844
      }
    }, {
      "from" : {
        "x" : 1065,
        "y" : 1844
      },
      "to" : {
        "x" : 1099,
        "y" : 1839
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 1059,
        "y" : 1838
      },
      "b" : {
        "x" : 1071,
        "y" : 1850
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 1065,
        "y" : 1844
      }
    },
    "inputs" : [ {
      "id" : 33766,
      "points" : [ {
        "x" : 1010,
        "y" : 1860
      } ]
    }, {
      "id" : 33762,
      "points" : [ {
        "x" : 985,
        "y" : 1810
      } ]
    } ],
    "outputs" : [ {
      "id" : 33767,
      "points" : [ {
        "x" : 1115,
        "y" : 1871
      } ]
    }, {
      "id" : 33741,
      "points" : [ {
        "x" : 1134,
        "y" : 1643
      } ]
    } ],
    "catalysts" : [ {
      "id" : 33768,
      "points" : [ {
        "x" : 951,
        "y" : 1972
      }, {
        "x" : 1063,
        "y" : 1894
      } ]
    } ]
  }, {
    "id" : 33830,
    "reactomeId" : 10267356,
    "displayName" : "p130 (RBL2) in complex with E2F4/5:DP1/2 binds to cyclin E/A:CDK2",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 1431,
      "y" : 1631
    },
    "minX" : 1400,
    "maxX" : 1476,
    "minY" : 1625,
    "maxY" : 1637,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 1476,
        "y" : 1632
      },
      "to" : {
        "x" : 1431,
        "y" : 1631
      }
    }, {
      "from" : {
        "x" : 1431,
        "y" : 1631
      },
      "to" : {
        "x" : 1400,
        "y" : 1631
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 1407,
        "y" : 1627
      },
      "b" : {
        "x" : 1400,
        "y" : 1631
      },
      "c" : {
        "x" : 1407,
        "y" : 1635
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 1407,
        "y" : 1635
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 1431,
        "y" : 1631
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 1431,
        "y" : 1631
      }
    },
    "inputs" : [ {
      "id" : 33821,
      "points" : [ {
        "x" : 1520,
        "y" : 1647
      } ]
    }, {
      "id" : 33831,
      "points" : [ {
        "x" : 1509,
        "y" : 1617
      } ]
    } ],
    "outputs" : [ {
      "id" : 33832
    } ]
  }, {
    "id" : 33833,
    "reactomeId" : 10267372,
    "displayName" : "Phosphorylated p130 (RBL2) binds SCF(Skp2):Cks1 complex",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 956,
      "y" : 698
    },
    "minX" : 889,
    "maxX" : 999,
    "minY" : 692,
    "maxY" : 721,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 999,
        "y" : 698
      },
      "to" : {
        "x" : 956,
        "y" : 698
      }
    }, {
      "from" : {
        "x" : 956,
        "y" : 698
      },
      "to" : {
        "x" : 889,
        "y" : 721
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 894,
        "y" : 715
      },
      "b" : {
        "x" : 889,
        "y" : 721
      },
      "c" : {
        "x" : 897,
        "y" : 723
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 897,
        "y" : 723
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 956,
        "y" : 698
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 956,
        "y" : 698
      }
    },
    "inputs" : [ {
      "id" : 33800,
      "points" : [ {
        "x" : 1025,
        "y" : 688
      } ]
    }, {
      "id" : 33834,
      "points" : [ {
        "x" : 1035,
        "y" : 714
      } ]
    } ],
    "outputs" : [ {
      "id" : 33835
    } ]
  }, {
    "id" : 33769,
    "reactomeId" : 10241312,
    "displayName" : "Cyclin E:CDK2-mediated phosphorylation of RB1",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 1783,
      "y" : 1312
    },
    "minX" : 1705,
    "maxX" : 1837,
    "minY" : 1295,
    "maxY" : 1324,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 1705,
        "y" : 1295
      },
      "to" : {
        "x" : 1783,
        "y" : 1312
      }
    }, {
      "from" : {
        "x" : 1783,
        "y" : 1312
      },
      "to" : {
        "x" : 1837,
        "y" : 1324
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 1777,
        "y" : 1306
      },
      "b" : {
        "x" : 1789,
        "y" : 1318
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 1783,
        "y" : 1312
      }
    },
    "inputs" : [ {
      "id" : 33770,
      "points" : [ {
        "x" : 1662,
        "y" : 1288
      } ]
    }, {
      "id" : 33771,
      "points" : [ {
        "x" : 1664,
        "y" : 1316
      } ],
      "stoichiometry" : 14
    } ],
    "outputs" : [ {
      "id" : 33772,
      "points" : [ {
        "x" : 1948,
        "y" : 1407
      } ],
      "stoichiometry" : 14
    }, {
      "id" : 33773,
      "points" : [ {
        "x" : 1841,
        "y" : 1368
      } ],
      "stoichiometry" : 14
    }, {
      "id" : 33774,
      "points" : [ {
        "x" : 1450,
        "y" : 1167
      }, {
        "x" : 1482,
        "y" : 1308
      }, {
        "x" : 1581,
        "y" : 1365
      } ]
    } ],
    "catalysts" : [ {
      "id" : 33770,
      "points" : [ {
        "x" : 1662,
        "y" : 1275
      }, {
        "x" : 1709,
        "y" : 1274
      } ]
    } ]
  }, {
    "id" : 33836,
    "reactomeId" : 10267377,
    "displayName" : "Ubiquitination of p130 (RBL2) by SCF (Skp2)",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 971,
      "y" : 781
    },
    "minX" : 927,
    "maxX" : 1011,
    "minY" : 775,
    "maxY" : 787,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 927,
        "y" : 781
      },
      "to" : {
        "x" : 971,
        "y" : 781
      }
    }, {
      "from" : {
        "x" : 971,
        "y" : 781
      },
      "to" : {
        "x" : 1011,
        "y" : 780
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 965,
        "y" : 775
      },
      "b" : {
        "x" : 977,
        "y" : 787
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 971,
        "y" : 781
      }
    },
    "inputs" : [ {
      "id" : 33835,
      "points" : [ {
        "x" : 889,
        "y" : 761
      } ]
    }, {
      "id" : 33837,
      "points" : [ {
        "x" : 872,
        "y" : 1064
      } ]
    } ],
    "outputs" : [ {
      "id" : 33838,
      "points" : [ {
        "x" : 1081,
        "y" : 992
      } ]
    }, {
      "id" : 33834,
      "points" : [ {
        "x" : 1046,
        "y" : 756
      } ]
    } ],
    "catalysts" : [ {
      "id" : 33835,
      "points" : [ {
        "x" : 889,
        "y" : 737
      }, {
        "x" : 969,
        "y" : 736
      } ]
    } ]
  }, {
    "id" : 33775,
    "reactomeId" : 10234583,
    "displayName" : "Detection of damage during initiation of DNA synthesis in S-phase",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 2274,
      "y" : 1808
    },
    "minX" : 2243,
    "maxX" : 2298,
    "minY" : 1802,
    "maxY" : 1814,
    "reactionType" : "dissociation",
    "segments" : [ {
      "from" : {
        "x" : 2243,
        "y" : 1809
      },
      "to" : {
        "x" : 2274,
        "y" : 1808
      }
    }, {
      "from" : {
        "x" : 2274,
        "y" : 1808
      },
      "to" : {
        "x" : 2298,
        "y" : 1807
      }
    } ],
    "reactionShape" : {
      "c" : {
        "x" : 2274,
        "y" : 1808
      },
      "r" : 5,
      "r1" : 3,
      "type" : "DOUBLE_CIRCLE",
      "empty" : true,
      "centre" : {
        "x" : 2274,
        "y" : 1808
      }
    },
    "inputs" : [ {
      "id" : 33776
    } ],
    "outputs" : [ {
      "id" : 33777,
      "points" : [ {
        "x" : 2306,
        "y" : 1768
      } ]
    }, {
      "id" : 33778,
      "points" : [ {
        "x" : 2328,
        "y" : 1865
      } ]
    } ]
  }, {
    "id" : 33839,
    "reactomeId" : 10312648,
    "displayName" : "Formation of CDK4/6:CCND complexes",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 228,
      "y" : 833
    },
    "minX" : 205,
    "maxX" : 270,
    "minY" : 799,
    "maxY" : 839,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 205,
        "y" : 827
      },
      "to" : {
        "x" : 228,
        "y" : 833
      }
    }, {
      "from" : {
        "x" : 228,
        "y" : 833
      },
      "to" : {
        "x" : 270,
        "y" : 799
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 267,
        "y" : 806
      },
      "b" : {
        "x" : 270,
        "y" : 799
      },
      "c" : {
        "x" : 262,
        "y" : 800
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 262,
        "y" : 800
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 228,
        "y" : 833
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 228,
        "y" : 833
      }
    },
    "inputs" : [ {
      "id" : 33787,
      "points" : [ {
        "x" : 181,
        "y" : 841
      } ]
    }, {
      "id" : 33840,
      "points" : [ {
        "x" : 177,
        "y" : 806
      } ]
    } ],
    "outputs" : [ {
      "id" : 33841
    } ],
    "inhibitors" : [ {
      "id" : 33788,
      "points" : [ {
        "x" : 230,
        "y" : 898
      } ]
    } ]
  }, {
    "id" : 33842,
    "reactomeId" : 10312657,
    "displayName" : "Cip/Kip CDK inhibitors bind CDK4/6:CCND complexes",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 365,
      "y" : 802
    },
    "minX" : 335,
    "maxX" : 382,
    "minY" : 774,
    "maxY" : 812,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 335,
        "y" : 812
      },
      "to" : {
        "x" : 365,
        "y" : 802
      }
    }, {
      "from" : {
        "x" : 365,
        "y" : 802
      },
      "to" : {
        "x" : 382,
        "y" : 774
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 382,
        "y" : 782
      },
      "b" : {
        "x" : 382,
        "y" : 774
      },
      "c" : {
        "x" : 375,
        "y" : 778
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 375,
        "y" : 778
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 365,
        "y" : 802
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 365,
        "y" : 802
      }
    },
    "inputs" : [ {
      "id" : 33841,
      "points" : [ {
        "x" : 320,
        "y" : 799
      } ]
    }, {
      "id" : 33843,
      "points" : [ {
        "x" : 337,
        "y" : 859
      } ]
    } ],
    "outputs" : [ {
      "id" : 33844
    } ]
  }, {
    "id" : 33779,
    "reactomeId" : 10234581,
    "displayName" : "PP2A mediated localization of RB1 protein in chromatin",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 2204,
      "y" : 1450
    },
    "minX" : 2134,
    "maxX" : 2221,
    "minY" : 1444,
    "maxY" : 1456,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 2134,
        "y" : 1444
      },
      "to" : {
        "x" : 2204,
        "y" : 1450
      }
    }, {
      "from" : {
        "x" : 2204,
        "y" : 1450
      },
      "to" : {
        "x" : 2221,
        "y" : 1451
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 2198,
        "y" : 1444
      },
      "b" : {
        "x" : 2210,
        "y" : 1456
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 2204,
        "y" : 1450
      }
    },
    "inputs" : [ {
      "id" : 33777,
      "points" : [ {
        "x" : 2296,
        "y" : 1712
      } ]
    }, {
      "id" : 33780,
      "points" : [ {
        "x" : 2118,
        "y" : 1502
      } ],
      "stoichiometry" : 14
    }, {
      "id" : 33772,
      "points" : [ {
        "x" : 2064,
        "y" : 1437
      } ]
    } ],
    "outputs" : [ {
      "id" : 33781,
      "points" : [ {
        "x" : 2239,
        "y" : 1453
      } ]
    }, {
      "id" : 33782,
      "points" : [ {
        "x" : 2239,
        "y" : 1516
      } ],
      "stoichiometry" : 14
    } ],
    "catalysts" : [ {
      "id" : 33783,
      "points" : [ {
        "x" : 2204,
        "y" : 1411
      } ]
    } ]
  }, {
    "id" : 33845,
    "reactomeId" : 10312746,
    "displayName" : "Tyrosine kinases phosphorylate Cip/Kip inhibitors bound to CDK4/6:CCND complexes",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 545,
      "y" : 711
    },
    "minX" : 515,
    "maxX" : 571,
    "minY" : 705,
    "maxY" : 717,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 515,
        "y" : 706
      },
      "to" : {
        "x" : 545,
        "y" : 711
      }
    }, {
      "from" : {
        "x" : 545,
        "y" : 711
      },
      "to" : {
        "x" : 571,
        "y" : 712
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 539,
        "y" : 705
      },
      "b" : {
        "x" : 551,
        "y" : 717
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 545,
        "y" : 711
      }
    },
    "inputs" : [ {
      "id" : 33846,
      "points" : [ {
        "x" : 501,
        "y" : 740
      } ]
    }, {
      "id" : 33844,
      "points" : [ {
        "x" : 447,
        "y" : 718
      } ]
    } ],
    "outputs" : [ {
      "id" : 33847,
      "points" : [ {
        "x" : 588,
        "y" : 707
      } ]
    }, {
      "id" : 33848,
      "points" : [ {
        "x" : 575,
        "y" : 742
      } ]
    } ],
    "catalysts" : [ {
      "id" : 33849,
      "points" : [ {
        "x" : 545,
        "y" : 638
      } ]
    } ]
  }, {
    "id" : 33784,
    "reactomeId" : 10241309,
    "displayName" : "Association of Rb with Cyclin E:Cdk2 complexes",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 1510,
      "y" : 1218
    },
    "minX" : 1504,
    "maxX" : 1558,
    "minY" : 1189,
    "maxY" : 1256,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 1506,
        "y" : 1189
      },
      "to" : {
        "x" : 1510,
        "y" : 1218
      }
    }, {
      "from" : {
        "x" : 1510,
        "y" : 1218
      },
      "to" : {
        "x" : 1558,
        "y" : 1256
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 1550,
        "y" : 1255
      },
      "b" : {
        "x" : 1558,
        "y" : 1256
      },
      "c" : {
        "x" : 1555,
        "y" : 1249
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 1555,
        "y" : 1249
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 1510,
        "y" : 1218
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 1510,
        "y" : 1218
      }
    },
    "inputs" : [ {
      "id" : 33774,
      "points" : [ {
        "x" : 1471,
        "y" : 1167
      } ]
    }, {
      "id" : 33731,
      "points" : [ {
        "x" : 1942,
        "y" : 1314
      } ]
    } ],
    "outputs" : [ {
      "id" : 33770
    } ]
  }, {
    "id" : 33785,
    "reactomeId" : 10240818,
    "displayName" : "Association of INK4 family proteins with CDK4/6",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 215,
      "y" : 967
    },
    "minX" : 179,
    "maxX" : 224,
    "minY" : 941,
    "maxY" : 973,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 179,
        "y" : 967
      },
      "to" : {
        "x" : 215,
        "y" : 967
      }
    }, {
      "from" : {
        "x" : 215,
        "y" : 967
      },
      "to" : {
        "x" : 224,
        "y" : 941
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 226,
        "y" : 949
      },
      "b" : {
        "x" : 224,
        "y" : 941
      },
      "c" : {
        "x" : 218,
        "y" : 946
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 218,
        "y" : 946
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 215,
        "y" : 967
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 215,
        "y" : 967
      }
    },
    "inputs" : [ {
      "id" : 33786,
      "points" : [ {
        "x" : 154,
        "y" : 983
      } ]
    }, {
      "id" : 33787,
      "points" : [ {
        "x" : 163,
        "y" : 886
      } ]
    } ],
    "outputs" : [ {
      "id" : 33788
    } ]
  }, {
    "id" : 33850,
    "reactomeId" : 10312792,
    "displayName" : "Translocation of CDK4/6:CCND complexes from the cytoplasm to the nucleus",
    "schemaClass" : "BlackBoxEvent",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 753,
      "y" : 1151
    },
    "minX" : 591,
    "maxX" : 837,
    "minY" : 1020,
    "maxY" : 1157,
    "reactionType" : "omitted",
    "segments" : [ {
      "from" : {
        "x" : 591,
        "y" : 1020
      },
      "to" : {
        "x" : 753,
        "y" : 1151
      }
    }, {
      "from" : {
        "x" : 753,
        "y" : 1151
      },
      "to" : {
        "x" : 837,
        "y" : 1153
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 830,
        "y" : 1157
      },
      "b" : {
        "x" : 837,
        "y" : 1153
      },
      "c" : {
        "x" : 830,
        "y" : 1149
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 830,
        "y" : 1149
      }
    },
    "reactionShape" : {
      "a" : {
        "x" : 747,
        "y" : 1145
      },
      "b" : {
        "x" : 759,
        "y" : 1157
      },
      "s" : "\\\\",
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 753,
        "y" : 1151
      }
    },
    "inputs" : [ {
      "id" : 33851
    } ],
    "outputs" : [ {
      "id" : 33852
    } ]
  }, {
    "id" : 33853,
    "reactomeId" : 10265823,
    "displayName" : "Cyclin D:CDK4/6 mediated phosphorylation of p107 (RBL1) and dissociation of phosphorylated p107 (p-RBL1) from DP1:E2F4 complex",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 2318,
      "y" : 617
    },
    "minX" : 2306,
    "maxX" : 2324,
    "minY" : 588,
    "maxY" : 645,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 2306,
        "y" : 588
      },
      "to" : {
        "x" : 2318,
        "y" : 617
      }
    }, {
      "from" : {
        "x" : 2318,
        "y" : 617
      },
      "to" : {
        "x" : 2315,
        "y" : 645
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 2312,
        "y" : 611
      },
      "b" : {
        "x" : 2324,
        "y" : 623
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 2318,
        "y" : 617
      }
    },
    "inputs" : [ {
      "id" : 33854,
      "points" : [ {
        "x" : 2346,
        "y" : 583
      } ],
      "stoichiometry" : 4
    }, {
      "id" : 33813,
      "points" : [ {
        "x" : 2220,
        "y" : 442
      }, {
        "x" : 2267,
        "y" : 452
      } ]
    } ],
    "outputs" : [ {
      "id" : 33855,
      "points" : [ {
        "x" : 2284,
        "y" : 702
      } ]
    }, {
      "id" : 33856,
      "points" : [ {
        "x" : 2385,
        "y" : 707
      } ]
    }, {
      "id" : 33857,
      "points" : [ {
        "x" : 2368,
        "y" : 638
      } ],
      "stoichiometry" : 4
    } ],
    "catalysts" : [ {
      "id" : 33733,
      "points" : [ {
        "x" : 1698,
        "y" : 851
      }, {
        "x" : 1978,
        "y" : 852
      } ]
    } ]
  }, {
    "id" : 33789,
    "reactomeId" : 10241226,
    "displayName" : "Translocation of p21 to the nucleus",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 652,
      "y" : 1255
    },
    "minX" : 520,
    "maxX" : 836,
    "minY" : 1249,
    "maxY" : 1261,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 520,
        "y" : 1250
      },
      "to" : {
        "x" : 652,
        "y" : 1255
      }
    }, {
      "from" : {
        "x" : 652,
        "y" : 1255
      },
      "to" : {
        "x" : 836,
        "y" : 1253
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 829,
        "y" : 1257
      },
      "b" : {
        "x" : 836,
        "y" : 1253
      },
      "c" : {
        "x" : 829,
        "y" : 1249
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 829,
        "y" : 1249
      }
    },
    "reactionShape" : {
      "a" : {
        "x" : 646,
        "y" : 1249
      },
      "b" : {
        "x" : 658,
        "y" : 1261
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 652,
        "y" : 1255
      }
    },
    "inputs" : [ {
      "id" : 33790
    } ],
    "outputs" : [ {
      "id" : 33791
    } ]
  } ],
  "compartments" : [ {
    "id" : 33874,
    "reactomeId" : 70101,
    "displayName" : "cytosol",
    "schemaClass" : "Compartment",
    "renderableClass" : "Compartment",
    "position" : {
      "x" : 1612,
      "y" : 1219
    },
    "minX" : 19,
    "maxX" : 3205,
    "minY" : 0,
    "maxY" : 2439,
    "prop" : {
      "x" : 19,
      "y" : 0,
      "width" : 3186,
      "height" : 2439
    },
    "textPosition" : {
      "x" : 117,
      "y" : 2375
    },
    "insets" : {
      "x" : 29,
      "y" : 10,
      "width" : 3166,
      "height" : 2419
    },
    "bgColor" : {
      "r" : 250,
      "g" : 240,
      "b" : 240
    },
    "componentIds" : [ 33873, 33875, 33737, 33738, 33739, 33736, 33785, 33786, 33787, 33788, 33790, 33793, 33792, 33789, 33920, 33921, 33895, 33900, 33924, 33901, 33902, 33925, 33926, 33927, 33904, 33928, 33839, 33841, 33840, 33842, 33930, 33931, 33932, 33844, 33843, 33845, 33846, 33848, 33849, 33903, 33905, 33933, 33851, 33912, 33934, 33847, 33866 ]
  }, {
    "id" : 33875,
    "reactomeId" : 7660,
    "displayName" : "nucleoplasm",
    "schemaClass" : "Compartment",
    "renderableClass" : "Compartment",
    "position" : {
      "x" : 1862,
      "y" : 1192
    },
    "minX" : 709,
    "maxX" : 3016,
    "minY" : 51,
    "maxY" : 2334,
    "prop" : {
      "x" : 709,
      "y" : 51,
      "width" : 2307,
      "height" : 2283
    },
    "textPosition" : {
      "x" : 727,
      "y" : 2276
    },
    "insets" : {
      "x" : 719,
      "y" : 61,
      "width" : 2287,
      "height" : 2263
    },
    "bgColor" : {
      "r" : 250,
      "g" : 240,
      "b" : 240
    },
    "componentIds" : [ 33728, 33864, 33740, 33741, 33742, 33743, 33744, 33745, 33746, 33747, 33748, 33749, 33751, 33750, 33752, 33755, 33753, 33754, 33756, 33758, 33821, 33759, 33760, 33762, 33761, 33763, 33765, 33766, 33767, 33768, 33774, 33769, 33770, 33881, 33882, 33778, 33775, 33776, 33777, 33779, 33781, 33784, 33729, 33791, 33794, 33863, 33795, 33797, 33798, 33799, 33800, 33796, 33813, 33801, 33802, 33803, 33804, 33805, 33806, 33807, 33808, 33860, 33809, 33811, 33812, 33814, 33783, 33815, 33816, 33817, 33818, 33820, 33823, 33824, 33826, 33827, 33829, 33830, 33828, 33822, 33832, 33831, 33825, 33833, 33835, 33834, 33836, 33838, 33837, 33922, 33923, 33819, 33810, 33850, 33852, 33733, 33853, 33854, 33855, 33856, 33857, 33858, 33859, 33861, 33935, 33936, 33862, 33757, 33764, 33865, 33731, 33771, 33772, 33773, 33780, 33782, 33867, 33869, 33870, 33872, 33937, 33868, 33871, 33735, 33734, 33938, 33939, 33919, 33940, 33941, 33732, 33730 ]
  } ],
  "notes" : [ ],
  "links" : [ {
    "id" : 33920,
    "renderableClass" : "EntitySetAndMemberLink",
    "position" : {
      "x" : 421,
      "y" : 1096
    },
    "minX" : 304,
    "maxX" : 482,
    "minY" : 1074,
    "maxY" : 1235,
    "segments" : [ {
      "from" : {
        "x" : 482,
        "y" : 1235
      },
      "to" : {
        "x" : 421,
        "y" : 1096
      }
    }, {
      "from" : {
        "x" : 421,
        "y" : 1096
      },
      "to" : {
        "x" : 304,
        "y" : 1074
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 415,
        "y" : 1090
      },
      "b" : {
        "x" : 427,
        "y" : 1102
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 421,
        "y" : 1096
      }
    },
    "inputs" : [ {
      "id" : 33790
    } ],
    "outputs" : [ {
      "id" : 33873
    } ]
  }, {
    "id" : 33921,
    "renderableClass" : "EntitySetAndMemberLink",
    "position" : {
      "x" : 328,
      "y" : 1062
    },
    "minX" : 304,
    "maxX" : 353,
    "minY" : 1056,
    "maxY" : 1068,
    "segments" : [ {
      "from" : {
        "x" : 353,
        "y" : 1059
      },
      "to" : {
        "x" : 304,
        "y" : 1065
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 322,
        "y" : 1056
      },
      "b" : {
        "x" : 334,
        "y" : 1068
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 328,
        "y" : 1062
      }
    },
    "inputs" : [ {
      "id" : 33793
    } ],
    "outputs" : [ {
      "id" : 33873
    } ]
  }, {
    "id" : 33922,
    "renderableClass" : "EntitySetAndMemberLink",
    "position" : {
      "x" : 930,
      "y" : 1269
    },
    "minX" : 903,
    "maxX" : 957,
    "minY" : 1261,
    "maxY" : 1278,
    "segments" : [ {
      "from" : {
        "x" : 903,
        "y" : 1261
      },
      "to" : {
        "x" : 957,
        "y" : 1278
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 924,
        "y" : 1263
      },
      "b" : {
        "x" : 936,
        "y" : 1275
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 930,
        "y" : 1269
      }
    },
    "inputs" : [ {
      "id" : 33791
    } ],
    "outputs" : [ {
      "id" : 33743
    } ]
  }, {
    "id" : 33923,
    "renderableClass" : "EntitySetAndMemberLink",
    "position" : {
      "x" : 934,
      "y" : 1294
    },
    "minX" : 911,
    "maxX" : 957,
    "minY" : 1288,
    "maxY" : 1300,
    "segments" : [ {
      "from" : {
        "x" : 911,
        "y" : 1298
      },
      "to" : {
        "x" : 957,
        "y" : 1291
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 928,
        "y" : 1288
      },
      "b" : {
        "x" : 940,
        "y" : 1300
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 934,
        "y" : 1294
      }
    },
    "inputs" : [ {
      "id" : 33794
    } ],
    "outputs" : [ {
      "id" : 33743
    } ]
  }, {
    "id" : 33925,
    "renderableClass" : "Interaction",
    "position" : {
      "x" : 111,
      "y" : 969
    },
    "minX" : 93,
    "maxX" : 129,
    "minY" : 956,
    "maxY" : 983,
    "interactionType" : "Activate",
    "segments" : [ {
      "from" : {
        "x" : 93,
        "y" : 956
      },
      "to" : {
        "x" : 129,
        "y" : 983
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 121,
        "y" : 982
      },
      "b" : {
        "x" : 129,
        "y" : 983
      },
      "c" : {
        "x" : 126,
        "y" : 976
      },
      "type" : "ARROW",
      "empty" : true,
      "centre" : {
        "x" : 126,
        "y" : 976
      }
    },
    "reactionShape" : {
      "a" : {
        "x" : 105,
        "y" : 963
      },
      "b" : {
        "x" : 117,
        "y" : 975
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 111,
        "y" : 969
      }
    },
    "inputs" : [ {
      "id" : 33901
    } ],
    "outputs" : [ {
      "id" : 33786
    } ]
  }, {
    "id" : 33926,
    "renderableClass" : "Interaction",
    "position" : {
      "x" : 127,
      "y" : 866
    },
    "minX" : 115,
    "maxX" : 140,
    "minY" : 749,
    "maxY" : 983,
    "interactionType" : "Activate",
    "segments" : [ {
      "from" : {
        "x" : 115,
        "y" : 749
      },
      "to" : {
        "x" : 140,
        "y" : 983
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 135,
        "y" : 977
      },
      "b" : {
        "x" : 140,
        "y" : 983
      },
      "c" : {
        "x" : 143,
        "y" : 976
      },
      "type" : "ARROW",
      "empty" : true,
      "centre" : {
        "x" : 143,
        "y" : 976
      }
    },
    "reactionShape" : {
      "a" : {
        "x" : 121,
        "y" : 860
      },
      "b" : {
        "x" : 133,
        "y" : 872
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 127,
        "y" : 866
      }
    },
    "inputs" : [ {
      "id" : 33902
    } ],
    "outputs" : [ {
      "id" : 33786
    } ]
  }, {
    "id" : 33927,
    "renderableClass" : "Interaction",
    "position" : {
      "x" : 142,
      "y" : 1036
    },
    "minX" : 136,
    "maxX" : 148,
    "minY" : 1017,
    "maxY" : 1056,
    "interactionType" : "Activate",
    "segments" : [ {
      "from" : {
        "x" : 143,
        "y" : 1056
      },
      "to" : {
        "x" : 142,
        "y" : 1017
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 146,
        "y" : 1024
      },
      "b" : {
        "x" : 142,
        "y" : 1017
      },
      "c" : {
        "x" : 138,
        "y" : 1024
      },
      "type" : "ARROW",
      "empty" : true,
      "centre" : {
        "x" : 138,
        "y" : 1024
      }
    },
    "reactionShape" : {
      "a" : {
        "x" : 136,
        "y" : 1030
      },
      "b" : {
        "x" : 148,
        "y" : 1042
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 142,
        "y" : 1036
      }
    },
    "inputs" : [ {
      "id" : 33903
    } ],
    "outputs" : [ {
      "id" : 33786
    } ]
  }, {
    "id" : 33928,
    "renderableClass" : "Interaction",
    "position" : {
      "x" : 186,
      "y" : 404
    },
    "minX" : 173,
    "maxX" : 199,
    "minY" : 383,
    "maxY" : 425,
    "interactionType" : "Activate",
    "segments" : [ {
      "from" : {
        "x" : 173,
        "y" : 425
      },
      "to" : {
        "x" : 199,
        "y" : 383
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 199,
        "y" : 391
      },
      "b" : {
        "x" : 199,
        "y" : 383
      },
      "c" : {
        "x" : 192,
        "y" : 387
      },
      "type" : "ARROW",
      "empty" : true,
      "centre" : {
        "x" : 192,
        "y" : 387
      }
    },
    "reactionShape" : {
      "a" : {
        "x" : 180,
        "y" : 398
      },
      "b" : {
        "x" : 192,
        "y" : 410
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 186,
        "y" : 404
      }
    },
    "inputs" : [ {
      "id" : 33904
    } ],
    "outputs" : [ {
      "id" : 33895
    } ]
  }, {
    "id" : 33929,
    "renderableClass" : "Interaction",
    "position" : {
      "x" : 18,
      "y" : 1063
    },
    "minX" : 12,
    "maxX" : 120,
    "minY" : 1017,
    "maxY" : 1223,
    "interactionType" : "Activate",
    "segments" : [ {
      "from" : {
        "x" : 104,
        "y" : 1223
      },
      "to" : {
        "x" : 18,
        "y" : 1063
      }
    }, {
      "from" : {
        "x" : 18,
        "y" : 1063
      },
      "to" : {
        "x" : 120,
        "y" : 1017
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 115,
        "y" : 1023
      },
      "b" : {
        "x" : 120,
        "y" : 1017
      },
      "c" : {
        "x" : 112,
        "y" : 1016
      },
      "type" : "ARROW",
      "empty" : true,
      "centre" : {
        "x" : 112,
        "y" : 1016
      }
    },
    "reactionShape" : {
      "a" : {
        "x" : 12,
        "y" : 1057
      },
      "b" : {
        "x" : 24,
        "y" : 1069
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 18,
        "y" : 1063
      }
    },
    "inputs" : [ {
      "id" : 33905
    } ],
    "outputs" : [ {
      "id" : 33786
    } ]
  }, {
    "id" : 33930,
    "renderableClass" : "EntitySetAndMemberLink",
    "position" : {
      "x" : 363,
      "y" : 981
    },
    "minX" : 345,
    "maxX" : 382,
    "minY" : 920,
    "maxY" : 1042,
    "segments" : [ {
      "from" : {
        "x" : 382,
        "y" : 1042
      },
      "to" : {
        "x" : 345,
        "y" : 920
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 357,
        "y" : 975
      },
      "b" : {
        "x" : 369,
        "y" : 987
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 363,
        "y" : 981
      }
    },
    "inputs" : [ {
      "id" : 33793
    } ],
    "outputs" : [ {
      "id" : 33843
    } ]
  }, {
    "id" : 33931,
    "renderableClass" : "EntitySetAndMemberLink",
    "position" : {
      "x" : 461,
      "y" : 1089
    },
    "minX" : 353,
    "maxX" : 486,
    "minY" : 920,
    "maxY" : 1235,
    "segments" : [ {
      "from" : {
        "x" : 486,
        "y" : 1235
      },
      "to" : {
        "x" : 461,
        "y" : 1089
      }
    }, {
      "from" : {
        "x" : 461,
        "y" : 1089
      },
      "to" : {
        "x" : 353,
        "y" : 920
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 455,
        "y" : 1083
      },
      "b" : {
        "x" : 467,
        "y" : 1095
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 461,
        "y" : 1089
      }
    },
    "inputs" : [ {
      "id" : 33790
    } ],
    "outputs" : [ {
      "id" : 33843
    } ]
  }, {
    "id" : 33932,
    "renderableClass" : "EntitySetAndEntitySetLink",
    "position" : {
      "x" : 299,
      "y" : 983
    },
    "minX" : 272,
    "maxX" : 327,
    "minY" : 920,
    "maxY" : 1046,
    "segments" : [ {
      "from" : {
        "x" : 327,
        "y" : 920
      },
      "to" : {
        "x" : 272,
        "y" : 1046
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 293,
        "y" : 977
      },
      "b" : {
        "x" : 305,
        "y" : 989
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 299,
        "y" : 983
      }
    },
    "inputs" : [ {
      "id" : 33843
    } ],
    "outputs" : [ {
      "id" : 33873
    } ]
  }, {
    "id" : 33933,
    "renderableClass" : "EntitySetAndMemberLink",
    "position" : {
      "x" : 485,
      "y" : 859
    },
    "minX" : 435,
    "maxX" : 535,
    "minY" : 774,
    "maxY" : 944,
    "segments" : [ {
      "from" : {
        "x" : 435,
        "y" : 774
      },
      "to" : {
        "x" : 535,
        "y" : 944
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 479,
        "y" : 853
      },
      "b" : {
        "x" : 491,
        "y" : 865
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 485,
        "y" : 859
      }
    },
    "inputs" : [ {
      "id" : 33844
    } ],
    "outputs" : [ {
      "id" : 33851
    } ]
  }, {
    "id" : 33934,
    "renderableClass" : "EntitySetAndMemberLink",
    "position" : {
      "x" : 652,
      "y" : 1754
    },
    "minX" : 646,
    "maxX" : 659,
    "minY" : 1737,
    "maxY" : 1771,
    "segments" : [ {
      "from" : {
        "x" : 646,
        "y" : 1771
      },
      "to" : {
        "x" : 659,
        "y" : 1737
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 646,
        "y" : 1748
      },
      "b" : {
        "x" : 658,
        "y" : 1760
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 652,
        "y" : 1754
      }
    },
    "inputs" : [ {
      "id" : 33912
    } ],
    "outputs" : [ {
      "id" : 33737
    } ]
  }, {
    "id" : 33937,
    "renderableClass" : "EntitySetAndEntitySetLink",
    "position" : {
      "x" : 1925,
      "y" : 951
    },
    "minX" : 1891,
    "maxX" : 1960,
    "minY" : 907,
    "maxY" : 996,
    "segments" : [ {
      "from" : {
        "x" : 1960,
        "y" : 907
      },
      "to" : {
        "x" : 1891,
        "y" : 996
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 1919,
        "y" : 945
      },
      "b" : {
        "x" : 1931,
        "y" : 957
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 1925,
        "y" : 951
      }
    },
    "inputs" : [ {
      "id" : 33872
    } ],
    "outputs" : [ {
      "id" : 33869
    } ]
  }, {
    "id" : 33938,
    "renderableClass" : "EntitySetAndMemberLink",
    "position" : {
      "x" : 1725,
      "y" : 868
    },
    "minX" : 1698,
    "maxX" : 1753,
    "minY" : 862,
    "maxY" : 874,
    "segments" : [ {
      "from" : {
        "x" : 1753,
        "y" : 872
      },
      "to" : {
        "x" : 1698,
        "y" : 864
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 1719,
        "y" : 862
      },
      "b" : {
        "x" : 1731,
        "y" : 874
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 1725,
        "y" : 868
      }
    },
    "inputs" : [ {
      "id" : 33871
    } ],
    "outputs" : [ {
      "id" : 33733
    } ]
  }, {
    "id" : 33939,
    "renderableClass" : "EntitySetAndMemberLink",
    "position" : {
      "x" : 1726,
      "y" : 912
    },
    "minX" : 1690,
    "maxX" : 1762,
    "minY" : 901,
    "maxY" : 924,
    "segments" : [ {
      "from" : {
        "x" : 1762,
        "y" : 924
      },
      "to" : {
        "x" : 1690,
        "y" : 901
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 1720,
        "y" : 906
      },
      "b" : {
        "x" : 1732,
        "y" : 918
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 1726,
        "y" : 912
      }
    },
    "inputs" : [ {
      "id" : 33868
    } ],
    "outputs" : [ {
      "id" : 33733
    } ]
  }, {
    "id" : 33940,
    "renderableClass" : "Interaction",
    "position" : {
      "x" : 2460,
      "y" : 2144
    },
    "minX" : 2286,
    "maxX" : 2635,
    "minY" : 2135,
    "maxY" : 2153,
    "interactionType" : "Activate",
    "segments" : [ {
      "from" : {
        "x" : 2635,
        "y" : 2153
      },
      "to" : {
        "x" : 2286,
        "y" : 2135
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 2293,
        "y" : 2131
      },
      "b" : {
        "x" : 2286,
        "y" : 2135
      },
      "c" : {
        "x" : 2293,
        "y" : 2139
      },
      "type" : "ARROW",
      "empty" : true,
      "centre" : {
        "x" : 2293,
        "y" : 2139
      }
    },
    "reactionShape" : {
      "a" : {
        "x" : 2454,
        "y" : 2138
      },
      "b" : {
        "x" : 2466,
        "y" : 2150
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 2460,
        "y" : 2144
      }
    },
    "inputs" : [ {
      "id" : 33882
    } ],
    "outputs" : [ {
      "id" : 33919
    } ]
  }, {
    "id" : 33941,
    "renderableClass" : "Interaction",
    "position" : {
      "x" : 2078,
      "y" : 1910
    },
    "minX" : 1974,
    "maxX" : 2183,
    "minY" : 1728,
    "maxY" : 2093,
    "interactionType" : "Activate",
    "segments" : [ {
      "from" : {
        "x" : 2183,
        "y" : 2093
      },
      "to" : {
        "x" : 1974,
        "y" : 1728
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 1981,
        "y" : 1732
      },
      "b" : {
        "x" : 1974,
        "y" : 1728
      },
      "c" : {
        "x" : 1974,
        "y" : 1736
      },
      "type" : "ARROW",
      "empty" : true,
      "centre" : {
        "x" : 1974,
        "y" : 1736
      }
    },
    "reactionShape" : {
      "a" : {
        "x" : 2072,
        "y" : 1904
      },
      "b" : {
        "x" : 2084,
        "y" : 1916
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 2078,
        "y" : 1910
      }
    },
    "inputs" : [ {
      "id" : 33919
    } ],
    "outputs" : [ {
      "id" : 33881
    } ]
  } ],
  "shadows" : [ {
    "id" : 33942,
    "reactomeId" : 10328527,
    "displayName" : "G1/S Transition",
    "schemaClass" : "Pathway",
    "renderableClass" : "Shadow",
    "position" : {
      "x" : 1374,
      "y" : 1521
    },
    "minX" : 346,
    "maxX" : 2402,
    "minY" : 1035,
    "maxY" : 2007,
    "prop" : {
      "x" : 346,
      "y" : 1365,
      "width" : 554,
      "height" : 525
    },
    "points" : [ {
      "x" : 346,
      "y" : 1035
    }, {
      "x" : 2402,
      "y" : 1035
    }, {
      "x" : 2402,
      "y" : 2007
    }, {
      "x" : 346,
      "y" : 2007
    } ],
    "colour" : "#4684ee"
  }, {
    "id" : 33943,
    "reactomeId" : 10328553,
    "displayName" : "G1 Phase",
    "schemaClass" : "Pathway",
    "renderableClass" : "Shadow",
    "position" : {
      "x" : 1375,
      "y" : 886
    },
    "minX" : 110,
    "maxX" : 2640,
    "minY" : 407,
    "maxY" : 1365,
    "prop" : {
      "x" : 110,
      "y" : 407,
      "width" : 790,
      "height" : 628
    },
    "points" : [ {
      "x" : 110,
      "y" : 407
    }, {
      "x" : 2640,
      "y" : 407
    }, {
      "x" : 2640,
      "y" : 1365
    }, {
      "x" : 110,
      "y" : 1365
    } ],
    "colour" : "#dc3912"
  }, {
    "id" : 33944,
    "reactomeId" : 10330645,
    "displayName" : "G0 and Early G1",
    "schemaClass" : "Pathway",
    "renderableClass" : "Shadow",
    "position" : {
      "x" : 1584,
      "y" : 1135
    },
    "minX" : 900,
    "maxX" : 2268,
    "minY" : 380,
    "maxY" : 1890,
    "prop" : {
      "x" : 900,
      "y" : 380,
      "width" : 1368,
      "height" : 1510
    },
    "points" : [ {
      "x" : 900,
      "y" : 380
    }, {
      "x" : 2268,
      "y" : 380
    }, {
      "x" : 2268,
      "y" : 1890
    }, {
      "x" : 900,
      "y" : 1890
    } ],
    "colour" : "#008000"
  } ],
  "minX" : 0,
  "maxX" : 3205,
  "minY" : 0,
  "maxY" : 2439,
  "disease" : false
}