{
  "dbId" : 10328517,
  "stableId" : "R-CFA-69239",
  "displayName" : "Synthesis of DNA",
  "nodes" : [ {
    "id" : 62848,
    "reactomeId" : 10240415,
    "displayName" : "GINS4",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 920,
      "y" : 459
    },
    "minX" : 894,
    "maxX" : 988,
    "minY" : 412,
    "maxY" : 470,
    "prop" : {
      "x" : 894,
      "y" : 448,
      "width" : 53,
      "height" : 22
    },
    "textPosition" : {
      "x" : 898,
      "y" : 448
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 947,
          "y" : 448
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 947,
          "y" : 448
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 62845,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 935,
          "y" : 445
        },
        "to" : {
          "x" : 988,
          "y" : 412
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 62849,
    "reactomeId" : 10240403,
    "displayName" : "GINS1",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 914,
      "y" : 342
    },
    "minX" : 885,
    "maxX" : 988,
    "minY" : 326,
    "maxY" : 412,
    "prop" : {
      "x" : 885,
      "y" : 332,
      "width" : 58,
      "height" : 20
    },
    "textPosition" : {
      "x" : 891,
      "y" : 332
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 943,
          "y" : 332
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 943,
          "y" : 332
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 62845,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 924,
          "y" : 355
        },
        "to" : {
          "x" : 988,
          "y" : 412
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 62850,
    "reactomeId" : 10240417,
    "displayName" : "GINS complex",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 1100,
      "y" : 410
    },
    "minX" : 1054,
    "maxX" : 1153,
    "minY" : 393,
    "maxY" : 421,
    "prop" : {
      "x" : 1054,
      "y" : 399,
      "width" : 93,
      "height" : 22
    },
    "textPosition" : {
      "x" : 1054,
      "y" : 400
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1147,
          "y" : 399
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1147,
          "y" : 399
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 62845,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 62852,
    "reactomeId" : 10227027,
    "displayName" : "RFC Heteropentamer",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 694,
      "y" : 657
    },
    "minX" : 630,
    "maxX" : 765,
    "minY" : 552,
    "maxY" : 724,
    "prop" : {
      "x" : 630,
      "y" : 644,
      "width" : 129,
      "height" : 26
    },
    "textPosition" : {
      "x" : 638,
      "y" : 635
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 759,
          "y" : 644
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 759,
          "y" : 644
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 62851,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 688,
          "y" : 641
        },
        "to" : {
          "x" : 650,
          "y" : 552
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 62860,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 705,
          "y" : 673
        },
        "to" : {
          "x" : 751,
          "y" : 724
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 713,
          "y" : 675
        },
        "b" : {
          "x" : 705,
          "y" : 673
        },
        "c" : {
          "x" : 707,
          "y" : 681
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 707,
          "y" : 681
        }
      }
    } ]
  }, {
    "id" : 62853,
    "reactomeId" : 10226923,
    "displayName" : "RNA primer-DNA primer:origin duplex",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 531,
      "y" : 388
    },
    "minX" : 466,
    "maxX" : 650,
    "minY" : 362,
    "maxY" : 552,
    "prop" : {
      "x" : 466,
      "y" : 368,
      "width" : 130,
      "height" : 41
    },
    "textPosition" : {
      "x" : 475,
      "y" : 360
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 596,
          "y" : 368
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 596,
          "y" : 368
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 62851,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 545,
          "y" : 412
        },
        "to" : {
          "x" : 650,
          "y" : 552
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 62893,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 62854,
    "reactomeId" : 10227029,
    "displayName" : "RFC Heteropentamer:RNA primer-DNA primer:origin duplex",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 812,
      "y" : 555
    },
    "minX" : 742,
    "maxX" : 916,
    "minY" : 520,
    "maxY" : 621,
    "prop" : {
      "x" : 742,
      "y" : 526,
      "width" : 141,
      "height" : 58
    },
    "textPosition" : {
      "x" : 740,
      "y" : 521
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 883,
          "y" : 526
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 883,
          "y" : 526
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 62851,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 62855,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 857,
          "y" : 587
        },
        "to" : {
          "x" : 916,
          "y" : 621
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 62856,
    "reactomeId" : 10227037,
    "displayName" : "PCNA homotrimer",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 809,
      "y" : 621
    },
    "minX" : 750,
    "maxX" : 916,
    "minY" : 604,
    "maxY" : 632,
    "prop" : {
      "x" : 750,
      "y" : 610,
      "width" : 118,
      "height" : 22
    },
    "textPosition" : {
      "x" : 750,
      "y" : 611
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 868,
          "y" : 610
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 868,
          "y" : 610
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 62855,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 871,
          "y" : 621
        },
        "to" : {
          "x" : 916,
          "y" : 621
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 62857,
    "reactomeId" : 29358,
    "displayName" : "ATP",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 863,
      "y" : 676
    },
    "minX" : 844,
    "maxX" : 916,
    "minY" : 621,
    "maxY" : 691,
    "prop" : {
      "x" : 844,
      "y" : 661,
      "width" : 39,
      "height" : 30
    },
    "textPosition" : {
      "x" : 848,
      "y" : 665
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 878,
          "y" : 666
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 878,
          "y" : 666
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 62855,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 877,
          "y" : 658
        },
        "to" : {
          "x" : 916,
          "y" : 621
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 62858,
    "reactomeId" : 113582,
    "displayName" : "ADP",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 1029,
      "y" : 593
    },
    "minX" : 987,
    "maxX" : 1050,
    "minY" : 577,
    "maxY" : 621,
    "prop" : {
      "x" : 1009,
      "y" : 578,
      "width" : 40,
      "height" : 30
    },
    "textPosition" : {
      "x" : 1012,
      "y" : 582
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1044,
          "y" : 583
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1044,
          "y" : 583
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 62855,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 1006,
          "y" : 606
        },
        "to" : {
          "x" : 987,
          "y" : 621
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 1003,
          "y" : 613
        },
        "b" : {
          "x" : 1006,
          "y" : 606
        },
        "c" : {
          "x" : 998,
          "y" : 607
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 998,
          "y" : 607
        }
      }
    } ]
  }, {
    "id" : 62859,
    "reactomeId" : 10227039,
    "displayName" : "RFC Heteropentamer:RNA primer-DNA primer:origin duplex:PCNA homotrimer",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 1086,
      "y" : 724
    },
    "minX" : 987,
    "maxX" : 1149,
    "minY" : 621,
    "maxY" : 770,
    "prop" : {
      "x" : 1030,
      "y" : 678,
      "width" : 113,
      "height" : 92
    },
    "textPosition" : {
      "x" : 1029,
      "y" : 679
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1143,
          "y" : 678
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1143,
          "y" : 678
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 62855,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 1041,
          "y" : 675
        },
        "to" : {
          "x" : 987,
          "y" : 621
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 1033,
          "y" : 673
        },
        "b" : {
          "x" : 1041,
          "y" : 675
        },
        "c" : {
          "x" : 1039,
          "y" : 667
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 1039,
          "y" : 667
        }
      }
    }, {
      "edgeId" : 62860,
      "type" : "INPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 62861,
    "reactomeId" : 10227043,
    "displayName" : "RNA primer-DNA primer:origin duplex:PCNA",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 682,
      "y" : 790
    },
    "minX" : 626,
    "maxX" : 832,
    "minY" : 724,
    "maxY" : 815,
    "prop" : {
      "x" : 626,
      "y" : 765,
      "width" : 113,
      "height" : 50
    },
    "textPosition" : {
      "x" : 627,
      "y" : 766
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 739,
          "y" : 765
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 739,
          "y" : 765
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 62860,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 708,
          "y" : 762
        },
        "to" : {
          "x" : 751,
          "y" : 724
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 711,
          "y" : 754
        },
        "b" : {
          "x" : 708,
          "y" : 762
        },
        "c" : {
          "x" : 716,
          "y" : 760
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 716,
          "y" : 760
        }
      }
    }, {
      "edgeId" : 62862,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 742,
          "y" : 791
        },
        "to" : {
          "x" : 832,
          "y" : 795
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 62863,
    "reactomeId" : 10227067,
    "displayName" : "DNA Polymerase delta tetramer",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 947,
      "y" : 778
    },
    "minX" : 832,
    "maxX" : 1011,
    "minY" : 754,
    "maxY" : 852,
    "prop" : {
      "x" : 890,
      "y" : 760,
      "width" : 115,
      "height" : 36
    },
    "textPosition" : {
      "x" : 890,
      "y" : 761
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1005,
          "y" : 760
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1005,
          "y" : 760
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 62862,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 887,
          "y" : 786
        },
        "to" : {
          "x" : 832,
          "y" : 795
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 62865,
      "type" : "CATALYST",
      "segments" : [ {
        "from" : {
          "x" : 947,
          "y" : 799
        },
        "to" : {
          "x" : 947,
          "y" : 844
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 947,
          "y" : 848
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 947,
          "y" : 848
        }
      }
    } ]
  }, {
    "id" : 62864,
    "reactomeId" : 10227069,
    "displayName" : "Processive complex",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 832,
      "y" : 861
    },
    "minX" : 767,
    "maxX" : 904,
    "minY" : 844,
    "maxY" : 872,
    "prop" : {
      "x" : 767,
      "y" : 850,
      "width" : 131,
      "height" : 22
    },
    "textPosition" : {
      "x" : 767,
      "y" : 851
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 898,
          "y" : 850
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 898,
          "y" : 850
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 62862,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 62865,
      "type" : "INPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 62866,
    "reactomeId" : 10227073,
    "displayName" : "Processive complex:Okazaki fragment complex",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 1060,
      "y" : 860
    },
    "minX" : 998,
    "maxX" : 1129,
    "minY" : 829,
    "maxY" : 885,
    "prop" : {
      "x" : 998,
      "y" : 835,
      "width" : 125,
      "height" : 50
    },
    "textPosition" : {
      "x" : 1000,
      "y" : 836
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1123,
          "y" : 835
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1123,
          "y" : 835
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 62865,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 62867,
      "type" : "INPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 62868,
    "reactomeId" : 10227078,
    "displayName" : "Processive complex:Okazaki fragment:Flap",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 1428,
      "y" : 863
    },
    "minX" : 1366,
    "maxX" : 1497,
    "minY" : 796,
    "maxY" : 888,
    "prop" : {
      "x" : 1366,
      "y" : 838,
      "width" : 125,
      "height" : 50
    },
    "textPosition" : {
      "x" : 1371,
      "y" : 839
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1491,
          "y" : 838
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1491,
          "y" : 838
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 62867,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 62869,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1443,
          "y" : 835
        },
        "to" : {
          "x" : 1469,
          "y" : 796
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 62870,
    "reactomeId" : 10227082,
    "displayName" : "RPA heterotrimer",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 1441,
      "y" : 749
    },
    "minX" : 1383,
    "maxX" : 1567,
    "minY" : 450,
    "maxY" : 796,
    "prop" : {
      "x" : 1383,
      "y" : 738,
      "width" : 116,
      "height" : 22
    },
    "textPosition" : {
      "x" : 1383,
      "y" : 739
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1499,
          "y" : 738
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1499,
          "y" : 738
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 62869,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1447,
          "y" : 763
        },
        "to" : {
          "x" : 1469,
          "y" : 796
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 62875,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 1442,
          "y" : 735
        },
        "to" : {
          "x" : 1463,
          "y" : 512
        }
      }, {
        "from" : {
          "x" : 1463,
          "y" : 512
        },
        "to" : {
          "x" : 1567,
          "y" : 450
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 1439,
          "y" : 728
        },
        "b" : {
          "x" : 1442,
          "y" : 735
        },
        "c" : {
          "x" : 1447,
          "y" : 728
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 1447,
          "y" : 728
        }
      }
    } ]
  }, {
    "id" : 62871,
    "reactomeId" : 10227084,
    "displayName" : "Processive complex:Okazaki fragment:Flap:RPA heterotrimer",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 1664,
      "y" : 696
    },
    "minX" : 1571,
    "maxX" : 1733,
    "minY" : 632,
    "maxY" : 728,
    "prop" : {
      "x" : 1602,
      "y" : 664,
      "width" : 125,
      "height" : 64
    },
    "textPosition" : {
      "x" : 1601,
      "y" : 665
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1727,
          "y" : 664
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1727,
          "y" : 664
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 62869,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 62872,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1617,
          "y" : 661
        },
        "to" : {
          "x" : 1571,
          "y" : 632
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 62873,
    "reactomeId" : 10227090,
    "displayName" : "DNA2",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 1527,
      "y" : 689
    },
    "minX" : 1486,
    "maxX" : 1571,
    "minY" : 450,
    "maxY" : 699,
    "prop" : {
      "x" : 1490,
      "y" : 679,
      "width" : 75,
      "height" : 20
    },
    "textPosition" : {
      "x" : 1506,
      "y" : 679
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1565,
          "y" : 679
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1565,
          "y" : 679
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 62872,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1534,
          "y" : 676
        },
        "to" : {
          "x" : 1571,
          "y" : 632
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 62875,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 1524,
          "y" : 676
        },
        "to" : {
          "x" : 1486,
          "y" : 512
        }
      }, {
        "from" : {
          "x" : 1486,
          "y" : 512
        },
        "to" : {
          "x" : 1567,
          "y" : 450
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 1519,
          "y" : 670
        },
        "b" : {
          "x" : 1524,
          "y" : 676
        },
        "c" : {
          "x" : 1526,
          "y" : 668
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 1526,
          "y" : 668
        }
      }
    } ]
  }, {
    "id" : 62874,
    "reactomeId" : 10227092,
    "displayName" : "Processive complex:Okazaki fragment:Flap:RPA heterotrimer:dna2",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 1570,
      "y" : 531
    },
    "minX" : 1508,
    "maxX" : 1639,
    "minY" : 493,
    "maxY" : 563,
    "prop" : {
      "x" : 1508,
      "y" : 499,
      "width" : 125,
      "height" : 64
    },
    "textPosition" : {
      "x" : 1507,
      "y" : 500
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1633,
          "y" : 499
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1633,
          "y" : 499
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 62872,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 62875,
      "type" : "INPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 62876,
    "reactomeId" : 418075,
    "displayName" : "UMP",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 1516,
      "y" : 374
    },
    "minX" : 1485,
    "maxX" : 1567,
    "minY" : 356,
    "maxY" : 450,
    "prop" : {
      "x" : 1485,
      "y" : 357,
      "width" : 63,
      "height" : 34
    },
    "textPosition" : {
      "x" : 1499,
      "y" : 363
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1543,
          "y" : 362
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1543,
          "y" : 362
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 62875,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 1527,
          "y" : 394
        },
        "to" : {
          "x" : 1567,
          "y" : 450
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 1534,
          "y" : 397
        },
        "b" : {
          "x" : 1527,
          "y" : 394
        },
        "c" : {
          "x" : 1528,
          "y" : 402
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 1528,
          "y" : 402
        }
      }
    } ]
  }, {
    "id" : 62877,
    "reactomeId" : 164121,
    "displayName" : "AMP",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 1611,
      "y" : 370
    },
    "minX" : 1567,
    "maxX" : 1633,
    "minY" : 354,
    "maxY" : 450,
    "prop" : {
      "x" : 1591,
      "y" : 355,
      "width" : 41,
      "height" : 30
    },
    "textPosition" : {
      "x" : 1594,
      "y" : 359
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1627,
          "y" : 360
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1627,
          "y" : 360
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 62875,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 1602,
          "y" : 388
        },
        "to" : {
          "x" : 1567,
          "y" : 450
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 1602,
          "y" : 396
        },
        "b" : {
          "x" : 1602,
          "y" : 388
        },
        "c" : {
          "x" : 1595,
          "y" : 392
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 1595,
          "y" : 392
        }
      }
    } ]
  }, {
    "id" : 62878,
    "reactomeId" : 418076,
    "displayName" : "CMP",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 1676,
      "y" : 420
    },
    "minX" : 1567,
    "maxX" : 1704,
    "minY" : 402,
    "maxY" : 450,
    "prop" : {
      "x" : 1649,
      "y" : 403,
      "width" : 54,
      "height" : 35
    },
    "textPosition" : {
      "x" : 1659,
      "y" : 410
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1698,
          "y" : 408
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1698,
          "y" : 408
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 62875,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 1646,
          "y" : 427
        },
        "to" : {
          "x" : 1567,
          "y" : 450
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 1640,
          "y" : 433
        },
        "b" : {
          "x" : 1646,
          "y" : 427
        },
        "c" : {
          "x" : 1638,
          "y" : 425
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 1638,
          "y" : 425
        }
      }
    } ]
  }, {
    "id" : 62879,
    "reactomeId" : 29626,
    "displayName" : "GMP",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 1467,
      "y" : 424
    },
    "minX" : 1438,
    "maxX" : 1567,
    "minY" : 406,
    "maxY" : 450,
    "prop" : {
      "x" : 1438,
      "y" : 407,
      "width" : 59,
      "height" : 35
    },
    "textPosition" : {
      "x" : 1450,
      "y" : 414
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1492,
          "y" : 412
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1492,
          "y" : 412
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 62875,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 1500,
          "y" : 431
        },
        "to" : {
          "x" : 1567,
          "y" : 450
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 1508,
          "y" : 429
        },
        "b" : {
          "x" : 1500,
          "y" : 431
        },
        "c" : {
          "x" : 1506,
          "y" : 437
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 1506,
          "y" : 437
        }
      }
    } ]
  }, {
    "id" : 62880,
    "reactomeId" : 10227096,
    "displayName" : "Processive complex:Okazaki fragments:Remaining Flap",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 1564,
      "y" : 291
    },
    "minX" : 1499,
    "maxX" : 1636,
    "minY" : 258,
    "maxY" : 450,
    "prop" : {
      "x" : 1499,
      "y" : 264,
      "width" : 131,
      "height" : 54
    },
    "textPosition" : {
      "x" : 1507,
      "y" : 255
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1630,
          "y" : 264
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1630,
          "y" : 264
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 62881,
      "type" : "INPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 62875,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 1564,
          "y" : 321
        },
        "to" : {
          "x" : 1567,
          "y" : 450
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 1568,
          "y" : 328
        },
        "b" : {
          "x" : 1564,
          "y" : 321
        },
        "c" : {
          "x" : 1560,
          "y" : 328
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 1560,
          "y" : 328
        }
      }
    } ]
  }, {
    "id" : 62882,
    "reactomeId" : 10227100,
    "displayName" : "Processive complex:nicked DNA from adjacent Okazaki fragments",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 1565,
      "y" : 159
    },
    "minX" : 1503,
    "maxX" : 1634,
    "minY" : 121,
    "maxY" : 191,
    "prop" : {
      "x" : 1503,
      "y" : 127,
      "width" : 125,
      "height" : 64
    },
    "textPosition" : {
      "x" : 1501,
      "y" : 128
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1628,
          "y" : 127
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1628,
          "y" : 127
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 62881,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 62883,
    "reactomeId" : 10227104,
    "displayName" : "FEN1",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 1489,
      "y" : 229
    },
    "minX" : 1459,
    "maxX" : 1555,
    "minY" : 213,
    "maxY" : 239,
    "prop" : {
      "x" : 1459,
      "y" : 219,
      "width" : 60,
      "height" : 20
    },
    "textPosition" : {
      "x" : 1469,
      "y" : 219
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1519,
          "y" : 219
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1519,
          "y" : 219
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 62881,
      "type" : "CATALYST",
      "segments" : [ {
        "from" : {
          "x" : 1522,
          "y" : 229
        },
        "to" : {
          "x" : 1547,
          "y" : 229
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 1551,
          "y" : 229
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1551,
          "y" : 229
        }
      }
    } ]
  }, {
    "id" : 62885,
    "reactomeId" : 68452,
    "displayName" : "Okazaki fragment",
    "schemaClass" : "OtherEntity",
    "renderableClass" : "Entity",
    "position" : {
      "x" : 1349,
      "y" : 103
    },
    "minX" : 1291,
    "maxX" : 1408,
    "minY" : 92,
    "maxY" : 114,
    "prop" : {
      "x" : 1291,
      "y" : 92,
      "width" : 117,
      "height" : 22
    },
    "textPosition" : {
      "x" : 1291,
      "y" : 92
    },
    "connectors" : [ {
      "edgeId" : 62884,
      "type" : "INPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 62886,
    "reactomeId" : 69172,
    "displayName" : "ligated okazaki fragment",
    "schemaClass" : "OtherEntity",
    "renderableClass" : "Entity",
    "position" : {
      "x" : 1691,
      "y" : 104
    },
    "minX" : 1638,
    "maxX" : 1744,
    "minY" : 86,
    "maxY" : 122,
    "prop" : {
      "x" : 1638,
      "y" : 86,
      "width" : 106,
      "height" : 36
    },
    "textPosition" : {
      "x" : 1638,
      "y" : 86
    },
    "connectors" : [ {
      "edgeId" : 62884,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 62887,
    "reactomeId" : 10227111,
    "displayName" : "LIG1",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 1437,
      "y" : 61
    },
    "minX" : 1420,
    "maxX" : 1461,
    "minY" : 44,
    "maxY" : 97,
    "prop" : {
      "x" : 1420,
      "y" : 50,
      "width" : 35,
      "height" : 22
    },
    "textPosition" : {
      "x" : 1420,
      "y" : 50
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1455,
          "y" : 50
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1455,
          "y" : 50
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 62884,
      "type" : "CATALYST",
      "segments" : [ {
        "from" : {
          "x" : 1437,
          "y" : 75
        },
        "to" : {
          "x" : 1437,
          "y" : 89
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 1438,
          "y" : 93
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1438,
          "y" : 93
        }
      }
    } ]
  }, {
    "id" : 62889,
    "reactomeId" : 9757634,
    "displayName" : "NTP",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 166,
      "y" : 250
    },
    "minX" : 146,
    "maxX" : 214,
    "minY" : 191,
    "maxY" : 266,
    "prop" : {
      "x" : 146,
      "y" : 235,
      "width" : 41,
      "height" : 31
    },
    "textPosition" : {
      "x" : 150,
      "y" : 240
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 182,
          "y" : 240
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 182,
          "y" : 240
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 62888,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 178,
          "y" : 232
        },
        "to" : {
          "x" : 214,
          "y" : 191
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 62890,
    "reactomeId" : 10226628,
    "displayName" : "DNA polymerase alpha:primase:DNA polymerase alpha:origin complex",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 112,
      "y" : 152
    },
    "minX" : 46,
    "maxX" : 260,
    "minY" : 114,
    "maxY" : 191,
    "prop" : {
      "x" : 46,
      "y" : 120,
      "width" : 132,
      "height" : 64
    },
    "textPosition" : {
      "x" : 46,
      "y" : 121
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 178,
          "y" : 120
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 178,
          "y" : 120
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 62888,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 181,
          "y" : 177
        },
        "to" : {
          "x" : 214,
          "y" : 191
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 62888,
      "type" : "CATALYST",
      "segments" : [ {
        "from" : {
          "x" : 181,
          "y" : 153
        },
        "to" : {
          "x" : 255,
          "y" : 155
        }
      }, {
        "from" : {
          "x" : 255,
          "y" : 155
        },
        "to" : {
          "x" : 256,
          "y" : 174
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 256,
          "y" : 178
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 256,
          "y" : 178
        }
      }
    } ]
  }, {
    "id" : 62891,
    "reactomeId" : 10226630,
    "displayName" : "RNA primer:origin duplex:DNA polymerase alpha:primase complex",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 340,
      "y" : 241
    },
    "minX" : 278,
    "maxX" : 527,
    "minY" : 189,
    "maxY" : 273,
    "prop" : {
      "x" : 278,
      "y" : 209,
      "width" : 124,
      "height" : 64
    },
    "textPosition" : {
      "x" : 278,
      "y" : 210
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 402,
          "y" : 209
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 402,
          "y" : 209
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 62888,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 307,
          "y" : 206
        },
        "to" : {
          "x" : 287,
          "y" : 189
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 299,
          "y" : 205
        },
        "b" : {
          "x" : 307,
          "y" : 206
        },
        "c" : {
          "x" : 304,
          "y" : 198
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 304,
          "y" : 198
        }
      }
    }, {
      "edgeId" : 62893,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 405,
          "y" : 243
        },
        "to" : {
          "x" : 527,
          "y" : 249
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 62892,
    "reactomeId" : 10226624,
    "displayName" : "DNA polymerase epsilon",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 332,
      "y" : 131
    },
    "minX" : 274,
    "maxX" : 396,
    "minY" : 107,
    "maxY" : 189,
    "prop" : {
      "x" : 274,
      "y" : 113,
      "width" : 116,
      "height" : 36
    },
    "textPosition" : {
      "x" : 275,
      "y" : 114
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 390,
          "y" : 113
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 390,
          "y" : 113
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 62888,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 318,
          "y" : 152
        },
        "to" : {
          "x" : 287,
          "y" : 189
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 317,
          "y" : 160
        },
        "b" : {
          "x" : 318,
          "y" : 152
        },
        "c" : {
          "x" : 310,
          "y" : 155
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 310,
          "y" : 155
        }
      }
    } ]
  }, {
    "id" : 62894,
    "reactomeId" : 29892,
    "displayName" : "dGTP",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 568,
      "y" : 163
    },
    "minX" : 527,
    "maxX" : 595,
    "minY" : 147,
    "maxY" : 249,
    "prop" : {
      "x" : 542,
      "y" : 148,
      "width" : 52,
      "height" : 30
    },
    "textPosition" : {
      "x" : 548,
      "y" : 152
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 589,
          "y" : 153
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 589,
          "y" : 153
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 62893,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 560,
          "y" : 181
        },
        "to" : {
          "x" : 527,
          "y" : 249
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 62895,
    "reactomeId" : 30187,
    "displayName" : "dTTP",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 501,
      "y" : 163
    },
    "minX" : 475,
    "maxX" : 528,
    "minY" : 147,
    "maxY" : 249,
    "prop" : {
      "x" : 475,
      "y" : 148,
      "width" : 52,
      "height" : 30
    },
    "textPosition" : {
      "x" : 482,
      "y" : 152
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 522,
          "y" : 153
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 522,
          "y" : 153
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 62893,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 505,
          "y" : 181
        },
        "to" : {
          "x" : 527,
          "y" : 249
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 62896,
    "reactomeId" : 30185,
    "displayName" : "dCTP",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 605,
      "y" : 206
    },
    "minX" : 527,
    "maxX" : 632,
    "minY" : 190,
    "maxY" : 249,
    "prop" : {
      "x" : 579,
      "y" : 191,
      "width" : 52,
      "height" : 30
    },
    "textPosition" : {
      "x" : 585,
      "y" : 195
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 626,
          "y" : 196
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 626,
          "y" : 196
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 62893,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 576,
          "y" : 220
        },
        "to" : {
          "x" : 527,
          "y" : 249
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 62897,
    "reactomeId" : 29604,
    "displayName" : "dATP",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 474,
      "y" : 206
    },
    "minX" : 448,
    "maxX" : 527,
    "minY" : 190,
    "maxY" : 249,
    "prop" : {
      "x" : 448,
      "y" : 191,
      "width" : 52,
      "height" : 30
    },
    "textPosition" : {
      "x" : 454,
      "y" : 195
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 495,
          "y" : 196
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 495,
          "y" : 196
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 62893,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 492,
          "y" : 224
        },
        "to" : {
          "x" : 527,
          "y" : 249
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 62898,
    "reactomeId" : 10226606,
    "displayName" : "DNA polymerase alpha:primase",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 426,
      "y" : 320
    },
    "minX" : 368,
    "maxX" : 520,
    "minY" : 296,
    "maxY" : 338,
    "prop" : {
      "x" : 368,
      "y" : 302,
      "width" : 116,
      "height" : 36
    },
    "textPosition" : {
      "x" : 369,
      "y" : 303
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 484,
          "y" : 302
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 484,
          "y" : 302
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 62893,
      "type" : "CATALYST",
      "segments" : [ {
        "from" : {
          "x" : 487,
          "y" : 318
        },
        "to" : {
          "x" : 512,
          "y" : 317
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 516,
          "y" : 317
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 516,
          "y" : 317
        }
      }
    } ]
  }, {
    "id" : 62900,
    "reactomeId" : 10226296,
    "displayName" : "CDT1",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 122,
      "y" : 377
    },
    "minX" : 101,
    "maxX" : 173,
    "minY" : 360,
    "maxY" : 409,
    "prop" : {
      "x" : 101,
      "y" : 366,
      "width" : 43,
      "height" : 22
    },
    "textPosition" : {
      "x" : 102,
      "y" : 366
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 144,
          "y" : 366
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 144,
          "y" : 366
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 62899,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 139,
          "y" : 391
        },
        "to" : {
          "x" : 173,
          "y" : 409
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 62901,
    "reactomeId" : 10226292,
    "displayName" : "GMNN",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 112,
      "y" : 449
    },
    "minX" : 89,
    "maxX" : 173,
    "minY" : 409,
    "maxY" : 460,
    "prop" : {
      "x" : 89,
      "y" : 438,
      "width" : 46,
      "height" : 22
    },
    "textPosition" : {
      "x" : 89,
      "y" : 438
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 135,
          "y" : 438
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 135,
          "y" : 438
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 62899,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 128,
          "y" : 435
        },
        "to" : {
          "x" : 173,
          "y" : 409
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 62902,
    "reactomeId" : 10226298,
    "displayName" : "CDT1:GMNN",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 326,
      "y" : 413
    },
    "minX" : 282,
    "maxX" : 377,
    "minY" : 396,
    "maxY" : 424,
    "prop" : {
      "x" : 282,
      "y" : 402,
      "width" : 89,
      "height" : 22
    },
    "textPosition" : {
      "x" : 286,
      "y" : 403
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 371,
          "y" : 402
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 371,
          "y" : 402
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 62899,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 62811,
    "reactomeId" : 29358,
    "displayName" : "ATP",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 147,
      "y" : 535
    },
    "minX" : 128,
    "maxX" : 205,
    "minY" : 519,
    "maxY" : 587,
    "prop" : {
      "x" : 128,
      "y" : 520,
      "width" : 39,
      "height" : 30
    },
    "textPosition" : {
      "x" : 132,
      "y" : 524
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 162,
          "y" : 525
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 162,
          "y" : 525
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 62810,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 163,
          "y" : 553
        },
        "to" : {
          "x" : 205,
          "y" : 587
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 62812,
    "reactomeId" : 10226730,
    "displayName" : "pre-replicative complex",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 266,
      "y" : 531
    },
    "minX" : 205,
    "maxX" : 321,
    "minY" : 507,
    "maxY" : 587,
    "prop" : {
      "x" : 217,
      "y" : 513,
      "width" : 98,
      "height" : 36
    },
    "textPosition" : {
      "x" : 216,
      "y" : 514
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 315,
          "y" : 513
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 315,
          "y" : 513
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 62810,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 246,
          "y" : 552
        },
        "to" : {
          "x" : 205,
          "y" : 587
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 62813,
    "reactomeId" : 113582,
    "displayName" : "ADP",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 140,
      "y" : 690
    },
    "minX" : 120,
    "maxX" : 204,
    "minY" : 670,
    "maxY" : 705,
    "prop" : {
      "x" : 120,
      "y" : 675,
      "width" : 40,
      "height" : 30
    },
    "textPosition" : {
      "x" : 123,
      "y" : 679
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 155,
          "y" : 680
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 155,
          "y" : 680
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 62810,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 163,
          "y" : 683
        },
        "to" : {
          "x" : 204,
          "y" : 670
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 168,
          "y" : 677
        },
        "b" : {
          "x" : 163,
          "y" : 683
        },
        "c" : {
          "x" : 171,
          "y" : 685
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 171,
          "y" : 685
        }
      }
    } ]
  }, {
    "id" : 62814,
    "reactomeId" : 10226742,
    "displayName" : "pre-replicative complex (Orc1-minus)",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 309,
      "y" : 684
    },
    "minX" : 204,
    "maxX" : 365,
    "minY" : 653,
    "maxY" : 709,
    "prop" : {
      "x" : 259,
      "y" : 659,
      "width" : 100,
      "height" : 50
    },
    "textPosition" : {
      "x" : 259,
      "y" : 660
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 359,
          "y" : 659
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 359,
          "y" : 659
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 62810,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 256,
          "y" : 677
        },
        "to" : {
          "x" : 204,
          "y" : 670
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 249,
          "y" : 680
        },
        "b" : {
          "x" : 256,
          "y" : 677
        },
        "c" : {
          "x" : 250,
          "y" : 672
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 250,
          "y" : 672
        }
      }
    } ]
  }, {
    "id" : 62815,
    "reactomeId" : 10226738,
    "displayName" : "phospho-ORC1",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 205,
      "y" : 735
    },
    "minX" : 140,
    "maxX" : 276,
    "minY" : 670,
    "maxY" : 779,
    "prop" : {
      "x" : 140,
      "y" : 724,
      "width" : 130,
      "height" : 22
    },
    "textPosition" : {
      "x" : 155,
      "y" : 724
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 270,
          "y" : 724
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 270,
          "y" : 724
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 62817,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 204,
          "y" : 749
        },
        "to" : {
          "x" : 204,
          "y" : 779
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 62810,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 204,
          "y" : 721
        },
        "to" : {
          "x" : 204,
          "y" : 670
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 200,
          "y" : 714
        },
        "b" : {
          "x" : 204,
          "y" : 721
        },
        "c" : {
          "x" : 208,
          "y" : 714
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 208,
          "y" : 714
        }
      }
    } ]
  }, {
    "id" : 62816,
    "reactomeId" : 10226757,
    "displayName" : "CCNA:p-T160-CDK2",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 484,
      "y" : 607
    },
    "minX" : 213,
    "maxX" : 554,
    "minY" : 583,
    "maxY" : 625,
    "prop" : {
      "x" : 421,
      "y" : 589,
      "width" : 127,
      "height" : 36
    },
    "textPosition" : {
      "x" : 422,
      "y" : 604
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 548,
          "y" : 589
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 548,
          "y" : 589
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 62810,
      "type" : "CATALYST",
      "segments" : [ {
        "from" : {
          "x" : 418,
          "y" : 609
        },
        "to" : {
          "x" : 221,
          "y" : 618
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 217,
          "y" : 618
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 217,
          "y" : 618
        }
      }
    } ]
  }, {
    "id" : 62818,
    "reactomeId" : 10226336,
    "displayName" : "Ub",
    "schemaClass" : "DefinedSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 111,
      "y" : 764
    },
    "minX" : 95,
    "maxX" : 204,
    "minY" : 752,
    "maxY" : 779,
    "prop" : {
      "x" : 95,
      "y" : 752,
      "width" : 32,
      "height" : 25
    },
    "textPosition" : {
      "x" : 98,
      "y" : 754
    },
    "connectors" : [ {
      "edgeId" : 62817,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 133,
          "y" : 766
        },
        "to" : {
          "x" : 204,
          "y" : 779
        }
      } ],
      "stoichiometry" : {
        "value" : 3,
        "shape" : {
          "a" : {
            "x" : 162,
            "y" : 766
          },
          "b" : {
            "x" : 174,
            "y" : 778
          },
          "type" : "BOX",
          "empty" : true,
          "centre" : {
            "x" : 168,
            "y" : 772
          }
        }
      }
    } ]
  }, {
    "id" : 62819,
    "reactomeId" : 10226763,
    "displayName" : "phospho-ORC1",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 141,
      "y" : 864
    },
    "minX" : 71,
    "maxX" : 217,
    "minY" : 846,
    "maxY" : 876,
    "prop" : {
      "x" : 71,
      "y" : 852,
      "width" : 140,
      "height" : 24
    },
    "textPosition" : {
      "x" : 91,
      "y" : 853
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 211,
          "y" : 852
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 211,
          "y" : 852
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 62817,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 62821,
      "type" : "INPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 62820,
    "reactomeId" : 10226779,
    "displayName" : "SCF (SKP2) complex",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 81,
      "y" : 816
    },
    "minX" : 45,
    "maxX" : 193,
    "minY" : 793,
    "maxY" : 834,
    "prop" : {
      "x" : 45,
      "y" : 799,
      "width" : 72,
      "height" : 35
    },
    "textPosition" : {
      "x" : 51,
      "y" : 785
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 117,
          "y" : 799
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 117,
          "y" : 799
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 62817,
      "type" : "CATALYST",
      "segments" : [ {
        "from" : {
          "x" : 120,
          "y" : 813
        },
        "to" : {
          "x" : 185,
          "y" : 807
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 189,
          "y" : 807
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 189,
          "y" : 807
        }
      }
    } ]
  }, {
    "id" : 62822,
    "reactomeId" : 10226784,
    "displayName" : "phospho-ORC1",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 154,
      "y" : 1007
    },
    "minX" : 86,
    "maxX" : 229,
    "minY" : 989,
    "maxY" : 1020,
    "prop" : {
      "x" : 86,
      "y" : 995,
      "width" : 137,
      "height" : 25
    },
    "textPosition" : {
      "x" : 104,
      "y" : 997
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 223,
          "y" : 995
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 223,
          "y" : 995
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 62821,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 62823,
      "type" : "INPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 62824,
    "reactomeId" : 10226816,
    "displayName" : "Ub",
    "schemaClass" : "DefinedSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 274,
      "y" : 1062
    },
    "minX" : 187,
    "maxX" : 486,
    "minY" : 1051,
    "maxY" : 1073,
    "prop" : {
      "x" : 245,
      "y" : 1051,
      "width" : 58,
      "height" : 22
    },
    "textPosition" : {
      "x" : 261,
      "y" : 1051
    },
    "connectors" : [ {
      "edgeId" : 62823,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 3,
        "shape" : {
          "a" : {
            "x" : 187,
            "y" : 1051
          },
          "b" : {
            "x" : 199,
            "y" : 1063
          },
          "type" : "BOX",
          "empty" : true,
          "centre" : {
            "x" : 193,
            "y" : 1057
          }
        }
      }
    }, {
      "edgeId" : 62834,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 309,
          "y" : 1061
        },
        "to" : {
          "x" : 486,
          "y" : 1061
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 62838,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 62825,
    "reactomeId" : 10226918,
    "displayName" : "26S proteasome",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 318,
      "y" : 1177
    },
    "minX" : 154,
    "maxX" : 365,
    "minY" : 1057,
    "maxY" : 1195,
    "prop" : {
      "x" : 277,
      "y" : 1160,
      "width" : 82,
      "height" : 35
    },
    "textPosition" : {
      "x" : 280,
      "y" : 1146
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 359,
          "y" : 1160
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 359,
          "y" : 1160
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 62823,
      "type" : "CATALYST",
      "segments" : [ {
        "from" : {
          "x" : 293,
          "y" : 1157
        },
        "to" : {
          "x" : 161,
          "y" : 1063
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 158,
          "y" : 1061
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 158,
          "y" : 1061
        }
      }
    }, {
      "edgeId" : 62838,
      "type" : "CATALYST",
      "segments" : [ {
        "from" : {
          "x" : 334,
          "y" : 1157
        },
        "to" : {
          "x" : 351,
          "y" : 1140
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 354,
          "y" : 1137
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 354,
          "y" : 1137
        }
      }
    } ]
  }, {
    "id" : 62827,
    "reactomeId" : 10226277,
    "displayName" : "CDC6",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 396,
      "y" : 739
    },
    "minX" : 372,
    "maxX" : 450,
    "minY" : 723,
    "maxY" : 763,
    "prop" : {
      "x" : 372,
      "y" : 729,
      "width" : 48,
      "height" : 20
    },
    "textPosition" : {
      "x" : 375,
      "y" : 729
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 420,
          "y" : 729
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 420,
          "y" : 729
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 62826,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 418,
          "y" : 752
        },
        "to" : {
          "x" : 450,
          "y" : 763
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 62828,
    "reactomeId" : 29358,
    "displayName" : "ATP",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 476,
      "y" : 725
    },
    "minX" : 450,
    "maxX" : 496,
    "minY" : 711,
    "maxY" : 763,
    "prop" : {
      "x" : 457,
      "y" : 712,
      "width" : 38,
      "height" : 26
    },
    "textPosition" : {
      "x" : 460,
      "y" : 714
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 490,
          "y" : 717
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 490,
          "y" : 717
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 62826,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 467,
          "y" : 741
        },
        "to" : {
          "x" : 450,
          "y" : 763
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 62829,
    "reactomeId" : 10226933,
    "displayName" : "phospho-CDC6",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 398,
      "y" : 861
    },
    "minX" : 362,
    "maxX" : 450,
    "minY" : 833,
    "maxY" : 875,
    "prop" : {
      "x" : 362,
      "y" : 848,
      "width" : 73,
      "height" : 27
    },
    "textPosition" : {
      "x" : 365,
      "y" : 844
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 435,
          "y" : 848
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 435,
          "y" : 848
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 62826,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 423,
          "y" : 845
        },
        "to" : {
          "x" : 450,
          "y" : 833
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 428,
          "y" : 839
        },
        "b" : {
          "x" : 423,
          "y" : 845
        },
        "c" : {
          "x" : 431,
          "y" : 846
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 431,
          "y" : 846
        }
      }
    }, {
      "edgeId" : 62832,
      "type" : "INPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 62830,
    "reactomeId" : 113582,
    "displayName" : "ADP",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 498,
      "y" : 867
    },
    "minX" : 450,
    "maxX" : 519,
    "minY" : 833,
    "maxY" : 882,
    "prop" : {
      "x" : 479,
      "y" : 853,
      "width" : 39,
      "height" : 29
    },
    "textPosition" : {
      "x" : 482,
      "y" : 857
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 513,
          "y" : 858
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 513,
          "y" : 858
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 62826,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 476,
          "y" : 853
        },
        "to" : {
          "x" : 450,
          "y" : 833
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 468,
          "y" : 852
        },
        "b" : {
          "x" : 476,
          "y" : 853
        },
        "c" : {
          "x" : 473,
          "y" : 846
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 473,
          "y" : 846
        }
      }
    } ]
  }, {
    "id" : 62831,
    "reactomeId" : 10226947,
    "displayName" : "CCNA:p-T160-CDK2,CCNE:p-T160-CDK2",
    "schemaClass" : "DefinedSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 549,
      "y" : 799
    },
    "minX" : 458,
    "maxX" : 614,
    "minY" : 774,
    "maxY" : 824,
    "prop" : {
      "x" : 484,
      "y" : 774,
      "width" : 130,
      "height" : 50
    },
    "textPosition" : {
      "x" : 485,
      "y" : 781
    },
    "connectors" : [ {
      "edgeId" : 62826,
      "type" : "CATALYST",
      "segments" : [ {
        "from" : {
          "x" : 478,
          "y" : 800
        },
        "to" : {
          "x" : 466,
          "y" : 800
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 462,
          "y" : 801
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 462,
          "y" : 801
        }
      }
    } ]
  }, {
    "id" : 62833,
    "reactomeId" : 10226952,
    "displayName" : "phospho-CDC6",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 407,
      "y" : 1014
    },
    "minX" : 370,
    "maxX" : 486,
    "minY" : 995,
    "maxY" : 1061,
    "prop" : {
      "x" : 370,
      "y" : 1001,
      "width" : 74,
      "height" : 26
    },
    "textPosition" : {
      "x" : 373,
      "y" : 997
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 444,
          "y" : 1001
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 444,
          "y" : 1001
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 62832,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 62834,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 428,
          "y" : 1030
        },
        "to" : {
          "x" : 486,
          "y" : 1061
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 62835,
    "reactomeId" : 113592,
    "displayName" : "ATP",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 450,
      "y" : 1094
    },
    "minX" : 431,
    "maxX" : 486,
    "minY" : 1061,
    "maxY" : 1109,
    "prop" : {
      "x" : 431,
      "y" : 1079,
      "width" : 39,
      "height" : 30
    },
    "textPosition" : {
      "x" : 435,
      "y" : 1083
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 465,
          "y" : 1084
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 465,
          "y" : 1084
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 62834,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 466,
          "y" : 1076
        },
        "to" : {
          "x" : 486,
          "y" : 1061
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 62836,
    "reactomeId" : 10226958,
    "displayName" : "ubiquitinated Cdc6",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 612,
      "y" : 1124
    },
    "minX" : 549,
    "maxX" : 682,
    "minY" : 1107,
    "maxY" : 1135,
    "prop" : {
      "x" : 549,
      "y" : 1113,
      "width" : 127,
      "height" : 22
    },
    "textPosition" : {
      "x" : 549,
      "y" : 1114
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 676,
          "y" : 1113
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 676,
          "y" : 1113
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 62834,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 62838,
      "type" : "INPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 62837,
    "reactomeId" : 10226998,
    "displayName" : "phospho-APC/C:Cdh1 complex",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 529,
      "y" : 992
    },
    "minX" : 474,
    "maxX" : 591,
    "minY" : 968,
    "maxY" : 1053,
    "prop" : {
      "x" : 474,
      "y" : 974,
      "width" : 111,
      "height" : 36
    },
    "textPosition" : {
      "x" : 476,
      "y" : 975
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 585,
          "y" : 974
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 585,
          "y" : 974
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 62834,
      "type" : "CATALYST",
      "segments" : [ {
        "from" : {
          "x" : 529,
          "y" : 1013
        },
        "to" : {
          "x" : 531,
          "y" : 1045
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 531,
          "y" : 1049
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 531,
          "y" : 1049
        }
      }
    } ]
  }, {
    "id" : 62840,
    "reactomeId" : 10226703,
    "displayName" : "MCM2-7",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 793,
      "y" : 132
    },
    "minX" : 738,
    "maxX" : 855,
    "minY" : 115,
    "maxY" : 143,
    "prop" : {
      "x" : 738,
      "y" : 121,
      "width" : 111,
      "height" : 22
    },
    "textPosition" : {
      "x" : 765,
      "y" : 122
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 849,
          "y" : 121
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 849,
          "y" : 121
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 62839,
      "type" : "INPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 62841,
    "reactomeId" : 10226699,
    "displayName" : "MCM5",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 731,
      "y" : 204
    },
    "minX" : 707,
    "maxX" : 794,
    "minY" : 187,
    "maxY" : 215,
    "prop" : {
      "x" : 707,
      "y" : 193,
      "width" : 48,
      "height" : 22
    },
    "textPosition" : {
      "x" : 709,
      "y" : 193
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 755,
          "y" : 193
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 755,
          "y" : 193
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 62839,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 758,
          "y" : 208
        },
        "to" : {
          "x" : 794,
          "y" : 215
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 766,
          "y" : 205
        },
        "b" : {
          "x" : 758,
          "y" : 208
        },
        "c" : {
          "x" : 764,
          "y" : 213
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 764,
          "y" : 213
        }
      }
    } ]
  }, {
    "id" : 62842,
    "reactomeId" : 10226689,
    "displayName" : "MCM4:MCM6:MCM7",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 790,
      "y" : 297
    },
    "minX" : 728,
    "maxX" : 858,
    "minY" : 215,
    "maxY" : 308,
    "prop" : {
      "x" : 728,
      "y" : 286,
      "width" : 124,
      "height" : 22
    },
    "textPosition" : {
      "x" : 728,
      "y" : 287
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 852,
          "y" : 286
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 852,
          "y" : 286
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 62839,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 790,
          "y" : 283
        },
        "to" : {
          "x" : 794,
          "y" : 215
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 786,
          "y" : 276
        },
        "b" : {
          "x" : 790,
          "y" : 283
        },
        "c" : {
          "x" : 794,
          "y" : 276
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 794,
          "y" : 276
        }
      }
    } ]
  }, {
    "id" : 62843,
    "reactomeId" : 10226675,
    "displayName" : "MCM2",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 839,
      "y" : 249
    },
    "minX" : 794,
    "maxX" : 870,
    "minY" : 215,
    "maxY" : 262,
    "prop" : {
      "x" : 814,
      "y" : 237,
      "width" : 50,
      "height" : 25
    },
    "textPosition" : {
      "x" : 817,
      "y" : 239
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 864,
          "y" : 237
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 864,
          "y" : 237
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 62839,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 822,
          "y" : 234
        },
        "to" : {
          "x" : 794,
          "y" : 215
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 814,
          "y" : 233
        },
        "b" : {
          "x" : 822,
          "y" : 234
        },
        "c" : {
          "x" : 819,
          "y" : 227
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 819,
          "y" : 227
        }
      }
    } ]
  }, {
    "id" : 62844,
    "reactomeId" : 10226695,
    "displayName" : "MCM3",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 742,
      "y" : 252
    },
    "minX" : 718,
    "maxX" : 794,
    "minY" : 215,
    "maxY" : 263,
    "prop" : {
      "x" : 718,
      "y" : 242,
      "width" : 48,
      "height" : 21
    },
    "textPosition" : {
      "x" : 720,
      "y" : 242
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 766,
          "y" : 242
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 766,
          "y" : 242
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 62839,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 756,
          "y" : 239
        },
        "to" : {
          "x" : 794,
          "y" : 215
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 760,
          "y" : 232
        },
        "b" : {
          "x" : 756,
          "y" : 239
        },
        "c" : {
          "x" : 764,
          "y" : 239
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 764,
          "y" : 239
        }
      }
    } ]
  }, {
    "id" : 62846,
    "reactomeId" : 10240411,
    "displayName" : "GINS3",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 903,
      "y" : 418
    },
    "minX" : 880,
    "maxX" : 988,
    "minY" : 401,
    "maxY" : 429,
    "prop" : {
      "x" : 880,
      "y" : 407,
      "width" : 46,
      "height" : 22
    },
    "textPosition" : {
      "x" : 880,
      "y" : 407
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 926,
          "y" : 407
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 926,
          "y" : 407
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 62845,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 929,
          "y" : 416
        },
        "to" : {
          "x" : 988,
          "y" : 412
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 62847,
    "reactomeId" : 10240407,
    "displayName" : "GINS2",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 903,
      "y" : 382
    },
    "minX" : 878,
    "maxX" : 988,
    "minY" : 364,
    "maxY" : 412,
    "prop" : {
      "x" : 878,
      "y" : 370,
      "width" : 50,
      "height" : 24
    },
    "textPosition" : {
      "x" : 880,
      "y" : 371
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 928,
          "y" : 370
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 928,
          "y" : 370
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 62845,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 931,
          "y" : 390
        },
        "to" : {
          "x" : 988,
          "y" : 412
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  } ],
  "edges" : [ {
    "id" : 62817,
    "reactomeId" : 10226782,
    "displayName" : "Phosphorylated Orc1 is ubiquitinated while still associated with chromatin",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 201,
      "y" : 806
    },
    "minX" : 153,
    "maxX" : 207,
    "minY" : 779,
    "maxY" : 849,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 204,
        "y" : 779
      },
      "to" : {
        "x" : 201,
        "y" : 806
      }
    }, {
      "from" : {
        "x" : 201,
        "y" : 806
      },
      "to" : {
        "x" : 153,
        "y" : 849
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 155,
        "y" : 841
      },
      "b" : {
        "x" : 153,
        "y" : 849
      },
      "c" : {
        "x" : 161,
        "y" : 847
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 161,
        "y" : 847
      }
    },
    "reactionShape" : {
      "a" : {
        "x" : 195,
        "y" : 800
      },
      "b" : {
        "x" : 207,
        "y" : 812
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 201,
        "y" : 806
      }
    },
    "inputs" : [ {
      "id" : 62815,
      "points" : [ {
        "x" : 204,
        "y" : 749
      } ]
    }, {
      "id" : 62818,
      "points" : [ {
        "x" : 133,
        "y" : 766
      } ],
      "stoichiometry" : 3
    } ],
    "outputs" : [ {
      "id" : 62819
    } ],
    "catalysts" : [ {
      "id" : 62820,
      "points" : [ {
        "x" : 120,
        "y" : 813
      } ]
    } ]
  }, {
    "id" : 62881,
    "reactomeId" : 10227107,
    "displayName" : "Removal of remaining Flap",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 1563,
      "y" : 229
    },
    "minX" : 1557,
    "maxX" : 1569,
    "minY" : 194,
    "maxY" : 261,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 1563,
        "y" : 261
      },
      "to" : {
        "x" : 1563,
        "y" : 229
      }
    }, {
      "from" : {
        "x" : 1563,
        "y" : 229
      },
      "to" : {
        "x" : 1564,
        "y" : 194
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 1568,
        "y" : 201
      },
      "b" : {
        "x" : 1564,
        "y" : 194
      },
      "c" : {
        "x" : 1560,
        "y" : 201
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 1560,
        "y" : 201
      }
    },
    "reactionShape" : {
      "a" : {
        "x" : 1557,
        "y" : 223
      },
      "b" : {
        "x" : 1569,
        "y" : 235
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 1563,
        "y" : 229
      }
    },
    "inputs" : [ {
      "id" : 62880
    } ],
    "outputs" : [ {
      "id" : 62882
    } ],
    "catalysts" : [ {
      "id" : 62883,
      "points" : [ {
        "x" : 1522,
        "y" : 229
      } ]
    } ]
  }, {
    "id" : 62851,
    "reactomeId" : 10227031,
    "displayName" : "RFC binding displaces Pol Alpha",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 680,
      "y" : 552
    },
    "minX" : 650,
    "maxX" : 739,
    "minY" : 546,
    "maxY" : 558,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 650,
        "y" : 552
      },
      "to" : {
        "x" : 680,
        "y" : 552
      }
    }, {
      "from" : {
        "x" : 680,
        "y" : 552
      },
      "to" : {
        "x" : 739,
        "y" : 553
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 732,
        "y" : 557
      },
      "b" : {
        "x" : 739,
        "y" : 553
      },
      "c" : {
        "x" : 732,
        "y" : 549
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 732,
        "y" : 549
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 680,
        "y" : 552
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 680,
        "y" : 552
      }
    },
    "inputs" : [ {
      "id" : 62852,
      "points" : [ {
        "x" : 688,
        "y" : 641
      } ]
    }, {
      "id" : 62853,
      "points" : [ {
        "x" : 545,
        "y" : 412
      } ]
    } ],
    "outputs" : [ {
      "id" : 62854
    } ]
  }, {
    "id" : 62884,
    "reactomeId" : 10227114,
    "displayName" : "Joining of adjacent Okazaki fragments",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 1438,
      "y" : 105
    },
    "minX" : 1411,
    "maxX" : 1635,
    "minY" : 99,
    "maxY" : 111,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 1411,
        "y" : 104
      },
      "to" : {
        "x" : 1438,
        "y" : 105
      }
    }, {
      "from" : {
        "x" : 1438,
        "y" : 105
      },
      "to" : {
        "x" : 1635,
        "y" : 104
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 1628,
        "y" : 108
      },
      "b" : {
        "x" : 1635,
        "y" : 104
      },
      "c" : {
        "x" : 1628,
        "y" : 100
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 1628,
        "y" : 100
      }
    },
    "reactionShape" : {
      "a" : {
        "x" : 1432,
        "y" : 99
      },
      "b" : {
        "x" : 1444,
        "y" : 111
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 1438,
        "y" : 105
      }
    },
    "inputs" : [ {
      "id" : 62885
    } ],
    "outputs" : [ {
      "id" : 62886
    } ],
    "catalysts" : [ {
      "id" : 62887,
      "points" : [ {
        "x" : 1437,
        "y" : 75
      } ]
    } ]
  }, {
    "id" : 62821,
    "reactomeId" : 10226786,
    "displayName" : "Ubiquitinated Orc1 enters the cytosol",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 159,
      "y" : 940
    },
    "minX" : 143,
    "maxX" : 165,
    "minY" : 879,
    "maxY" : 992,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 143,
        "y" : 879
      },
      "to" : {
        "x" : 159,
        "y" : 940
      }
    }, {
      "from" : {
        "x" : 159,
        "y" : 940
      },
      "to" : {
        "x" : 154,
        "y" : 992
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 151,
        "y" : 985
      },
      "b" : {
        "x" : 154,
        "y" : 992
      },
      "c" : {
        "x" : 159,
        "y" : 985
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 159,
        "y" : 985
      }
    },
    "reactionShape" : {
      "a" : {
        "x" : 153,
        "y" : 934
      },
      "b" : {
        "x" : 165,
        "y" : 946
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 159,
        "y" : 940
      }
    },
    "inputs" : [ {
      "id" : 62819
    } ],
    "outputs" : [ {
      "id" : 62822
    } ]
  }, {
    "id" : 62823,
    "reactomeId" : 10226921,
    "displayName" : "Ubiquitinated Orc1 is degraded by the proteasome",
    "schemaClass" : "BlackBoxEvent",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 148,
      "y" : 1054
    },
    "minX" : 142,
    "maxX" : 239,
    "minY" : 1023,
    "maxY" : 1060,
    "reactionType" : "omitted",
    "segments" : [ {
      "from" : {
        "x" : 152,
        "y" : 1023
      },
      "to" : {
        "x" : 148,
        "y" : 1054
      }
    }, {
      "from" : {
        "x" : 148,
        "y" : 1054
      },
      "to" : {
        "x" : 239,
        "y" : 1060
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 232,
        "y" : 1064
      },
      "b" : {
        "x" : 239,
        "y" : 1060
      },
      "c" : {
        "x" : 232,
        "y" : 1056
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 232,
        "y" : 1056
      }
    },
    "reactionShape" : {
      "a" : {
        "x" : 142,
        "y" : 1048
      },
      "b" : {
        "x" : 154,
        "y" : 1060
      },
      "s" : "\\\\",
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 148,
        "y" : 1054
      }
    },
    "inputs" : [ {
      "id" : 62822
    } ],
    "outputs" : [ {
      "id" : 62824,
      "stoichiometry" : 3
    } ],
    "catalysts" : [ {
      "id" : 62825,
      "points" : [ {
        "x" : 293,
        "y" : 1157
      } ]
    } ]
  }, {
    "id" : 62855,
    "reactomeId" : 10227041,
    "displayName" : "Loading of PCNA - Sliding Clamp Formation",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 946,
      "y" : 621
    },
    "minX" : 916,
    "maxX" : 987,
    "minY" : 615,
    "maxY" : 627,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 916,
        "y" : 621
      },
      "to" : {
        "x" : 946,
        "y" : 621
      }
    }, {
      "from" : {
        "x" : 946,
        "y" : 621
      },
      "to" : {
        "x" : 987,
        "y" : 621
      }
    } ],
    "reactionShape" : {
      "c" : {
        "x" : 946,
        "y" : 621
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 946,
        "y" : 621
      }
    },
    "inputs" : [ {
      "id" : 62856,
      "points" : [ {
        "x" : 871,
        "y" : 621
      } ]
    }, {
      "id" : 62854,
      "points" : [ {
        "x" : 857,
        "y" : 587
      } ]
    }, {
      "id" : 62857,
      "points" : [ {
        "x" : 877,
        "y" : 658
      } ]
    } ],
    "outputs" : [ {
      "id" : 62858,
      "points" : [ {
        "x" : 1006,
        "y" : 606
      } ]
    }, {
      "id" : 62859,
      "points" : [ {
        "x" : 1041,
        "y" : 675
      } ]
    } ]
  }, {
    "id" : 62888,
    "reactomeId" : 10226633,
    "displayName" : "The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer at the origin",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 256,
      "y" : 190
    },
    "minX" : 214,
    "maxX" : 287,
    "minY" : 184,
    "maxY" : 196,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 214,
        "y" : 191
      },
      "to" : {
        "x" : 256,
        "y" : 190
      }
    }, {
      "from" : {
        "x" : 256,
        "y" : 190
      },
      "to" : {
        "x" : 287,
        "y" : 189
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 250,
        "y" : 184
      },
      "b" : {
        "x" : 262,
        "y" : 196
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 256,
        "y" : 190
      }
    },
    "inputs" : [ {
      "id" : 62889,
      "points" : [ {
        "x" : 178,
        "y" : 232
      } ]
    }, {
      "id" : 62890,
      "points" : [ {
        "x" : 181,
        "y" : 177
      } ]
    } ],
    "outputs" : [ {
      "id" : 62891,
      "points" : [ {
        "x" : 307,
        "y" : 206
      } ]
    }, {
      "id" : 62892,
      "points" : [ {
        "x" : 318,
        "y" : 152
      } ]
    } ],
    "catalysts" : [ {
      "id" : 62890,
      "points" : [ {
        "x" : 181,
        "y" : 153
      }, {
        "x" : 255,
        "y" : 155
      } ]
    } ]
  }, {
    "id" : 62826,
    "reactomeId" : 10226950,
    "displayName" : "Cdc6 protein is phosphorylated by CDK",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 450,
      "y" : 801
    },
    "minX" : 444,
    "maxX" : 456,
    "minY" : 763,
    "maxY" : 833,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 450,
        "y" : 763
      },
      "to" : {
        "x" : 450,
        "y" : 801
      }
    }, {
      "from" : {
        "x" : 450,
        "y" : 801
      },
      "to" : {
        "x" : 450,
        "y" : 833
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 444,
        "y" : 795
      },
      "b" : {
        "x" : 456,
        "y" : 807
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 450,
        "y" : 801
      }
    },
    "inputs" : [ {
      "id" : 62827,
      "points" : [ {
        "x" : 418,
        "y" : 752
      } ]
    }, {
      "id" : 62828,
      "points" : [ {
        "x" : 467,
        "y" : 741
      } ]
    } ],
    "outputs" : [ {
      "id" : 62829,
      "points" : [ {
        "x" : 423,
        "y" : 845
      } ]
    }, {
      "id" : 62830,
      "points" : [ {
        "x" : 476,
        "y" : 853
      } ]
    } ],
    "catalysts" : [ {
      "id" : 62831,
      "points" : [ {
        "x" : 478,
        "y" : 800
      } ]
    } ]
  }, {
    "id" : 62860,
    "reactomeId" : 10227045,
    "displayName" : "RFC dissociates after sliding clamp formation",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 811,
      "y" : 725
    },
    "minX" : 751,
    "maxX" : 1027,
    "minY" : 719,
    "maxY" : 731,
    "reactionType" : "dissociation",
    "segments" : [ {
      "from" : {
        "x" : 1027,
        "y" : 724
      },
      "to" : {
        "x" : 811,
        "y" : 725
      }
    }, {
      "from" : {
        "x" : 811,
        "y" : 725
      },
      "to" : {
        "x" : 751,
        "y" : 724
      }
    } ],
    "reactionShape" : {
      "c" : {
        "x" : 811,
        "y" : 725
      },
      "r" : 5,
      "r1" : 3,
      "type" : "DOUBLE_CIRCLE",
      "empty" : true,
      "centre" : {
        "x" : 811,
        "y" : 725
      }
    },
    "inputs" : [ {
      "id" : 62859
    } ],
    "outputs" : [ {
      "id" : 62852,
      "points" : [ {
        "x" : 705,
        "y" : 673
      } ]
    }, {
      "id" : 62861,
      "points" : [ {
        "x" : 708,
        "y" : 762
      } ]
    } ]
  }, {
    "id" : 62893,
    "reactomeId" : 10226926,
    "displayName" : "The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer at the origin",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 528,
      "y" : 317
    },
    "minX" : 522,
    "maxX" : 534,
    "minY" : 249,
    "maxY" : 365,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 527,
        "y" : 249
      },
      "to" : {
        "x" : 528,
        "y" : 317
      }
    }, {
      "from" : {
        "x" : 528,
        "y" : 317
      },
      "to" : {
        "x" : 530,
        "y" : 365
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 526,
        "y" : 358
      },
      "b" : {
        "x" : 530,
        "y" : 365
      },
      "c" : {
        "x" : 534,
        "y" : 358
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 534,
        "y" : 358
      }
    },
    "reactionShape" : {
      "a" : {
        "x" : 522,
        "y" : 311
      },
      "b" : {
        "x" : 534,
        "y" : 323
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 528,
        "y" : 317
      }
    },
    "inputs" : [ {
      "id" : 62894,
      "points" : [ {
        "x" : 560,
        "y" : 181
      } ]
    }, {
      "id" : 62895,
      "points" : [ {
        "x" : 505,
        "y" : 181
      } ]
    }, {
      "id" : 62896,
      "points" : [ {
        "x" : 576,
        "y" : 220
      } ]
    }, {
      "id" : 62891,
      "points" : [ {
        "x" : 405,
        "y" : 243
      } ]
    }, {
      "id" : 62897,
      "points" : [ {
        "x" : 492,
        "y" : 224
      } ]
    } ],
    "outputs" : [ {
      "id" : 62853
    } ],
    "catalysts" : [ {
      "id" : 62898,
      "points" : [ {
        "x" : 487,
        "y" : 318
      } ]
    } ]
  }, {
    "id" : 62862,
    "reactomeId" : 10227071,
    "displayName" : "Formation of Processive Complex",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 832,
      "y" : 817
    },
    "minX" : 826,
    "maxX" : 838,
    "minY" : 795,
    "maxY" : 847,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 832,
        "y" : 795
      },
      "to" : {
        "x" : 832,
        "y" : 817
      }
    }, {
      "from" : {
        "x" : 832,
        "y" : 817
      },
      "to" : {
        "x" : 832,
        "y" : 847
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 828,
        "y" : 840
      },
      "b" : {
        "x" : 832,
        "y" : 847
      },
      "c" : {
        "x" : 836,
        "y" : 840
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 836,
        "y" : 840
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 832,
        "y" : 817
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 832,
        "y" : 817
      }
    },
    "inputs" : [ {
      "id" : 62863,
      "points" : [ {
        "x" : 887,
        "y" : 786
      } ]
    }, {
      "id" : 62861,
      "points" : [ {
        "x" : 742,
        "y" : 791
      } ]
    } ],
    "outputs" : [ {
      "id" : 62864
    } ]
  }, {
    "id" : 62832,
    "reactomeId" : 10226954,
    "displayName" : "Phosphorylated Cdc6 is exported from the nucleus",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 405,
      "y" : 929
    },
    "minX" : 399,
    "maxX" : 411,
    "minY" : 878,
    "maxY" : 998,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 399,
        "y" : 878
      },
      "to" : {
        "x" : 405,
        "y" : 929
      }
    }, {
      "from" : {
        "x" : 405,
        "y" : 929
      },
      "to" : {
        "x" : 406,
        "y" : 998
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 402,
        "y" : 991
      },
      "b" : {
        "x" : 406,
        "y" : 998
      },
      "c" : {
        "x" : 410,
        "y" : 991
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 410,
        "y" : 991
      }
    },
    "reactionShape" : {
      "a" : {
        "x" : 399,
        "y" : 923
      },
      "b" : {
        "x" : 411,
        "y" : 935
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 405,
        "y" : 929
      }
    },
    "inputs" : [ {
      "id" : 62829
    } ],
    "outputs" : [ {
      "id" : 62833
    } ]
  }, {
    "id" : 62865,
    "reactomeId" : 10227076,
    "displayName" : "Formation of Okazaki fragments",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 947,
      "y" : 860
    },
    "minX" : 901,
    "maxX" : 995,
    "minY" : 854,
    "maxY" : 866,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 901,
        "y" : 860
      },
      "to" : {
        "x" : 947,
        "y" : 860
      }
    }, {
      "from" : {
        "x" : 947,
        "y" : 860
      },
      "to" : {
        "x" : 995,
        "y" : 860
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 988,
        "y" : 864
      },
      "b" : {
        "x" : 995,
        "y" : 860
      },
      "c" : {
        "x" : 988,
        "y" : 856
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 988,
        "y" : 856
      }
    },
    "reactionShape" : {
      "a" : {
        "x" : 941,
        "y" : 854
      },
      "b" : {
        "x" : 953,
        "y" : 866
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 947,
        "y" : 860
      }
    },
    "inputs" : [ {
      "id" : 62864
    } ],
    "outputs" : [ {
      "id" : 62866
    } ],
    "catalysts" : [ {
      "id" : 62863,
      "points" : [ {
        "x" : 947,
        "y" : 799
      } ]
    } ]
  }, {
    "id" : 62834,
    "reactomeId" : 10227001,
    "displayName" : "Cytoplasmic phosphorylated Cdc6 is ubiquitinated by the anaphase-promoting complex",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 532,
      "y" : 1061
    },
    "minX" : 486,
    "maxX" : 598,
    "minY" : 1055,
    "maxY" : 1110,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 486,
        "y" : 1061
      },
      "to" : {
        "x" : 532,
        "y" : 1061
      }
    }, {
      "from" : {
        "x" : 532,
        "y" : 1061
      },
      "to" : {
        "x" : 598,
        "y" : 1110
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 590,
        "y" : 1109
      },
      "b" : {
        "x" : 598,
        "y" : 1110
      },
      "c" : {
        "x" : 595,
        "y" : 1103
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 595,
        "y" : 1103
      }
    },
    "reactionShape" : {
      "a" : {
        "x" : 526,
        "y" : 1055
      },
      "b" : {
        "x" : 538,
        "y" : 1067
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 532,
        "y" : 1061
      }
    },
    "inputs" : [ {
      "id" : 62824,
      "points" : [ {
        "x" : 309,
        "y" : 1061
      } ]
    }, {
      "id" : 62833,
      "points" : [ {
        "x" : 428,
        "y" : 1030
      } ]
    }, {
      "id" : 62835,
      "points" : [ {
        "x" : 466,
        "y" : 1076
      } ]
    } ],
    "outputs" : [ {
      "id" : 62836
    } ],
    "catalysts" : [ {
      "id" : 62837,
      "points" : [ {
        "x" : 529,
        "y" : 1013
      } ]
    } ]
  }, {
    "id" : 62899,
    "reactomeId" : 10227290,
    "displayName" : "CDT1 binds geminin",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 208,
      "y" : 415
    },
    "minX" : 173,
    "maxX" : 279,
    "minY" : 409,
    "maxY" : 421,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 173,
        "y" : 409
      },
      "to" : {
        "x" : 208,
        "y" : 415
      }
    }, {
      "from" : {
        "x" : 208,
        "y" : 415
      },
      "to" : {
        "x" : 279,
        "y" : 413
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 272,
        "y" : 417
      },
      "b" : {
        "x" : 279,
        "y" : 413
      },
      "c" : {
        "x" : 272,
        "y" : 409
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 272,
        "y" : 409
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 208,
        "y" : 415
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 208,
        "y" : 415
      }
    },
    "inputs" : [ {
      "id" : 62900,
      "points" : [ {
        "x" : 139,
        "y" : 391
      } ]
    }, {
      "id" : 62901,
      "points" : [ {
        "x" : 128,
        "y" : 435
      } ]
    } ],
    "outputs" : [ {
      "id" : 62902
    } ]
  }, {
    "id" : 62867,
    "reactomeId" : 10227080,
    "displayName" : "Formation of the Flap Intermediate",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 1297,
      "y" : 860
    },
    "minX" : 1126,
    "maxX" : 1363,
    "minY" : 854,
    "maxY" : 866,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 1126,
        "y" : 860
      },
      "to" : {
        "x" : 1297,
        "y" : 860
      }
    }, {
      "from" : {
        "x" : 1297,
        "y" : 860
      },
      "to" : {
        "x" : 1363,
        "y" : 861
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 1356,
        "y" : 865
      },
      "b" : {
        "x" : 1363,
        "y" : 861
      },
      "c" : {
        "x" : 1356,
        "y" : 857
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 1356,
        "y" : 857
      }
    },
    "reactionShape" : {
      "a" : {
        "x" : 1291,
        "y" : 854
      },
      "b" : {
        "x" : 1303,
        "y" : 866
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 1297,
        "y" : 860
      }
    },
    "inputs" : [ {
      "id" : 62866
    } ],
    "outputs" : [ {
      "id" : 62868
    } ]
  }, {
    "id" : 62869,
    "reactomeId" : 10227086,
    "displayName" : "RPA binds to the Flap",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 1514,
      "y" : 796
    },
    "minX" : 1469,
    "maxX" : 1616,
    "minY" : 731,
    "maxY" : 802,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 1469,
        "y" : 796
      },
      "to" : {
        "x" : 1514,
        "y" : 796
      }
    }, {
      "from" : {
        "x" : 1514,
        "y" : 796
      },
      "to" : {
        "x" : 1616,
        "y" : 731
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 1612,
        "y" : 738
      },
      "b" : {
        "x" : 1616,
        "y" : 731
      },
      "c" : {
        "x" : 1608,
        "y" : 731
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 1608,
        "y" : 731
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 1514,
        "y" : 796
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 1514,
        "y" : 796
      }
    },
    "inputs" : [ {
      "id" : 62868,
      "points" : [ {
        "x" : 1443,
        "y" : 835
      } ]
    }, {
      "id" : 62870,
      "points" : [ {
        "x" : 1447,
        "y" : 763
      } ]
    } ],
    "outputs" : [ {
      "id" : 62871
    } ]
  }, {
    "id" : 62838,
    "reactomeId" : 10227003,
    "displayName" : "Ubiquitinated Cdc6 is degraded by the proteasome",
    "schemaClass" : "BlackBoxEvent",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 363,
      "y" : 1129
    },
    "minX" : 288,
    "maxX" : 546,
    "minY" : 1079,
    "maxY" : 1135,
    "reactionType" : "omitted",
    "segments" : [ {
      "from" : {
        "x" : 546,
        "y" : 1125
      },
      "to" : {
        "x" : 363,
        "y" : 1129
      }
    }, {
      "from" : {
        "x" : 363,
        "y" : 1129
      },
      "to" : {
        "x" : 288,
        "y" : 1079
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 296,
        "y" : 1080
      },
      "b" : {
        "x" : 288,
        "y" : 1079
      },
      "c" : {
        "x" : 292,
        "y" : 1086
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 292,
        "y" : 1086
      }
    },
    "reactionShape" : {
      "a" : {
        "x" : 357,
        "y" : 1123
      },
      "b" : {
        "x" : 369,
        "y" : 1135
      },
      "s" : "\\\\",
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 363,
        "y" : 1129
      }
    },
    "inputs" : [ {
      "id" : 62836
    } ],
    "outputs" : [ {
      "id" : 62824
    } ],
    "catalysts" : [ {
      "id" : 62825,
      "points" : [ {
        "x" : 334,
        "y" : 1157
      } ]
    } ]
  }, {
    "id" : 62839,
    "reactomeId" : 10227005,
    "displayName" : "Mcm4,6,7 trimer forms and associates with the replication fork",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 793,
      "y" : 187
    },
    "minX" : 787,
    "maxX" : 799,
    "minY" : 146,
    "maxY" : 215,
    "reactionType" : "dissociation",
    "segments" : [ {
      "from" : {
        "x" : 793,
        "y" : 146
      },
      "to" : {
        "x" : 793,
        "y" : 187
      }
    }, {
      "from" : {
        "x" : 793,
        "y" : 187
      },
      "to" : {
        "x" : 794,
        "y" : 215
      }
    } ],
    "reactionShape" : {
      "c" : {
        "x" : 793,
        "y" : 187
      },
      "r" : 5,
      "r1" : 3,
      "type" : "DOUBLE_CIRCLE",
      "empty" : true,
      "centre" : {
        "x" : 793,
        "y" : 187
      }
    },
    "inputs" : [ {
      "id" : 62840
    } ],
    "outputs" : [ {
      "id" : 62841,
      "points" : [ {
        "x" : 758,
        "y" : 208
      } ]
    }, {
      "id" : 62842,
      "points" : [ {
        "x" : 790,
        "y" : 283
      } ]
    }, {
      "id" : 62843,
      "points" : [ {
        "x" : 822,
        "y" : 234
      } ]
    }, {
      "id" : 62844,
      "points" : [ {
        "x" : 756,
        "y" : 239
      } ]
    } ]
  }, {
    "id" : 62872,
    "reactomeId" : 10227094,
    "displayName" : "Recruitment of Dna2 endonuclease",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 1571,
      "y" : 602
    },
    "minX" : 1565,
    "maxX" : 1577,
    "minY" : 566,
    "maxY" : 632,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 1571,
        "y" : 632
      },
      "to" : {
        "x" : 1571,
        "y" : 602
      }
    }, {
      "from" : {
        "x" : 1571,
        "y" : 602
      },
      "to" : {
        "x" : 1570,
        "y" : 566
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 1574,
        "y" : 573
      },
      "b" : {
        "x" : 1570,
        "y" : 566
      },
      "c" : {
        "x" : 1566,
        "y" : 573
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 1566,
        "y" : 573
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 1571,
        "y" : 602
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 1571,
        "y" : 602
      }
    },
    "inputs" : [ {
      "id" : 62873,
      "points" : [ {
        "x" : 1534,
        "y" : 676
      } ]
    }, {
      "id" : 62871,
      "points" : [ {
        "x" : 1617,
        "y" : 661
      } ]
    } ],
    "outputs" : [ {
      "id" : 62874
    } ]
  }, {
    "id" : 62810,
    "reactomeId" : 10226760,
    "displayName" : "Orc1 is phosphorylated by cyclin A/CDK2",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 205,
      "y" : 619
    },
    "minX" : 199,
    "maxX" : 211,
    "minY" : 587,
    "maxY" : 670,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 205,
        "y" : 587
      },
      "to" : {
        "x" : 205,
        "y" : 619
      }
    }, {
      "from" : {
        "x" : 205,
        "y" : 619
      },
      "to" : {
        "x" : 204,
        "y" : 670
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 199,
        "y" : 613
      },
      "b" : {
        "x" : 211,
        "y" : 625
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 205,
        "y" : 619
      }
    },
    "inputs" : [ {
      "id" : 62811,
      "points" : [ {
        "x" : 163,
        "y" : 553
      } ]
    }, {
      "id" : 62812,
      "points" : [ {
        "x" : 246,
        "y" : 552
      } ]
    } ],
    "outputs" : [ {
      "id" : 62813,
      "points" : [ {
        "x" : 163,
        "y" : 683
      } ]
    }, {
      "id" : 62814,
      "points" : [ {
        "x" : 256,
        "y" : 677
      } ]
    }, {
      "id" : 62815,
      "points" : [ {
        "x" : 204,
        "y" : 721
      } ]
    } ],
    "catalysts" : [ {
      "id" : 62816,
      "points" : [ {
        "x" : 418,
        "y" : 609
      } ]
    } ]
  }, {
    "id" : 62875,
    "reactomeId" : 10227098,
    "displayName" : "Removal of RNA primer and dissociation of RPA and Dna2",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 1567,
      "y" : 472
    },
    "minX" : 1561,
    "maxX" : 1573,
    "minY" : 450,
    "maxY" : 496,
    "reactionType" : "dissociation",
    "segments" : [ {
      "from" : {
        "x" : 1568,
        "y" : 496
      },
      "to" : {
        "x" : 1567,
        "y" : 472
      }
    }, {
      "from" : {
        "x" : 1567,
        "y" : 472
      },
      "to" : {
        "x" : 1567,
        "y" : 450
      }
    } ],
    "reactionShape" : {
      "c" : {
        "x" : 1567,
        "y" : 472
      },
      "r" : 5,
      "r1" : 3,
      "type" : "DOUBLE_CIRCLE",
      "empty" : true,
      "centre" : {
        "x" : 1567,
        "y" : 472
      }
    },
    "inputs" : [ {
      "id" : 62874
    } ],
    "outputs" : [ {
      "id" : 62876,
      "points" : [ {
        "x" : 1527,
        "y" : 394
      } ]
    }, {
      "id" : 62873,
      "points" : [ {
        "x" : 1524,
        "y" : 676
      }, {
        "x" : 1486,
        "y" : 512
      } ]
    }, {
      "id" : 62877,
      "points" : [ {
        "x" : 1602,
        "y" : 388
      } ]
    }, {
      "id" : 62878,
      "points" : [ {
        "x" : 1646,
        "y" : 427
      } ]
    }, {
      "id" : 62870,
      "points" : [ {
        "x" : 1442,
        "y" : 735
      }, {
        "x" : 1463,
        "y" : 512
      } ]
    }, {
      "id" : 62879,
      "points" : [ {
        "x" : 1500,
        "y" : 431
      } ]
    }, {
      "id" : 62880,
      "points" : [ {
        "x" : 1564,
        "y" : 321
      } ]
    } ]
  }, {
    "id" : 62845,
    "reactomeId" : 10240419,
    "displayName" : "Formation of GINS complex",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 1025,
      "y" : 412
    },
    "minX" : 988,
    "maxX" : 1051,
    "minY" : 406,
    "maxY" : 418,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 988,
        "y" : 412
      },
      "to" : {
        "x" : 1025,
        "y" : 412
      }
    }, {
      "from" : {
        "x" : 1025,
        "y" : 412
      },
      "to" : {
        "x" : 1051,
        "y" : 411
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 1044,
        "y" : 415
      },
      "b" : {
        "x" : 1051,
        "y" : 411
      },
      "c" : {
        "x" : 1044,
        "y" : 407
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 1044,
        "y" : 407
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 1025,
        "y" : 412
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 1025,
        "y" : 412
      }
    },
    "inputs" : [ {
      "id" : 62846,
      "points" : [ {
        "x" : 929,
        "y" : 416
      } ]
    }, {
      "id" : 62847,
      "points" : [ {
        "x" : 931,
        "y" : 390
      } ]
    }, {
      "id" : 62848,
      "points" : [ {
        "x" : 935,
        "y" : 445
      } ]
    }, {
      "id" : 62849,
      "points" : [ {
        "x" : 924,
        "y" : 355
      } ]
    } ],
    "outputs" : [ {
      "id" : 62850
    } ]
  } ],
  "compartments" : [ {
    "id" : 62903,
    "reactomeId" : 7660,
    "displayName" : "nucleoplasm",
    "schemaClass" : "Compartment",
    "renderableClass" : "Compartment",
    "position" : {
      "x" : 908,
      "y" : 479
    },
    "minX" : 18,
    "maxX" : 1799,
    "minY" : 18,
    "maxY" : 941,
    "prop" : {
      "x" : 18,
      "y" : 18,
      "width" : 1781,
      "height" : 923
    },
    "textPosition" : {
      "x" : 33,
      "y" : 883
    },
    "insets" : {
      "x" : 28,
      "y" : 28,
      "width" : 1761,
      "height" : 903
    },
    "bgColor" : {
      "r" : 250,
      "g" : 240,
      "b" : 240
    },
    "componentIds" : [ 62891, 62853, 62813, 62814, 62817, 62818, 62810, 62811, 62812, 62815, 62821, 62826, 62827, 62828, 62832, 62839, 62840, 62841, 62842, 62843, 62844, 62845, 62848, 62849, 62847, 62850, 62851, 62852, 62854, 62855, 62856, 62857, 62858, 62859, 62860, 62861, 62862, 62863, 62864, 62865, 62866, 62867, 62868, 62869, 62870, 62871, 62872, 62873, 62874, 62875, 62876, 62877, 62878, 62879, 62880, 62881, 62882, 62883, 62884, 62885, 62886, 62829, 62830, 62846, 62887, 62888, 62890, 62892, 62893, 62894, 62895, 62896, 62897, 62898, 62819, 62820, 62831, 62907, 62816, 62899, 62900, 62901, 62902, 62889 ]
  }, {
    "id" : 62904,
    "reactomeId" : 70101,
    "displayName" : "cytosol",
    "schemaClass" : "Compartment",
    "renderableClass" : "Compartment",
    "position" : {
      "x" : 912,
      "y" : 614
    },
    "minX" : 0,
    "maxX" : 1825,
    "minY" : 0,
    "maxY" : 1228,
    "prop" : {
      "x" : 0,
      "y" : 0,
      "width" : 1825,
      "height" : 1228
    },
    "textPosition" : {
      "x" : 19,
      "y" : 1176
    },
    "insets" : {
      "x" : 10,
      "y" : 10,
      "width" : 1805,
      "height" : 1208
    },
    "bgColor" : {
      "r" : 250,
      "g" : 240,
      "b" : 240
    },
    "componentIds" : [ 62823, 62824, 62825, 62833, 62835, 62836, 62838, 62834, 62903, 62822, 62837 ]
  } ],
  "notes" : [ ],
  "links" : [ {
    "id" : 62907,
    "renderableClass" : "EntitySetAndMemberLink",
    "position" : {
      "x" : 515,
      "y" : 698
    },
    "minX" : 490,
    "maxX" : 540,
    "minY" : 628,
    "maxY" : 768,
    "segments" : [ {
      "from" : {
        "x" : 490,
        "y" : 628
      },
      "to" : {
        "x" : 540,
        "y" : 768
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 509,
        "y" : 692
      },
      "b" : {
        "x" : 521,
        "y" : 704
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 515,
        "y" : 698
      }
    },
    "inputs" : [ {
      "id" : 62816
    } ],
    "outputs" : [ {
      "id" : 62831
    } ]
  } ],
  "shadows" : [ {
    "id" : 62908,
    "reactomeId" : 10328515,
    "displayName" : "DNA replication initiation",
    "schemaClass" : "Pathway",
    "renderableClass" : "Shadow",
    "position" : {
      "x" : 338,
      "y" : 261
    },
    "minX" : 36,
    "maxX" : 641,
    "minY" : 103,
    "maxY" : 419,
    "prop" : {
      "x" : 36,
      "y" : 103,
      "width" : 605,
      "height" : 316
    },
    "points" : [ {
      "x" : 36,
      "y" : 103
    }, {
      "x" : 641,
      "y" : 103
    }, {
      "x" : 641,
      "y" : 419
    }, {
      "x" : 36,
      "y" : 419
    } ],
    "colour" : "#4684ee"
  }, {
    "id" : 62909,
    "reactomeId" : 10328533,
    "displayName" : "Switching of origins to a post-replicative state",
    "schemaClass" : "Pathway",
    "renderableClass" : "Shadow",
    "position" : {
      "x" : 454,
      "y" : 658
    },
    "minX" : 35,
    "maxX" : 874,
    "minY" : 111,
    "maxY" : 1205,
    "prop" : {
      "x" : 35,
      "y" : 898,
      "width" : 839,
      "height" : 307
    },
    "points" : [ {
      "x" : 35,
      "y" : 111
    }, {
      "x" : 874,
      "y" : 111
    }, {
      "x" : 874,
      "y" : 1205
    }, {
      "x" : 35,
      "y" : 1205
    } ],
    "colour" : "#dc3912"
  }, {
    "id" : 62910,
    "reactomeId" : 10328541,
    "displayName" : "DNA strand elongation",
    "schemaClass" : "Pathway",
    "renderableClass" : "Shadow",
    "position" : {
      "x" : 1105,
      "y" : 469
    },
    "minX" : 456,
    "maxX" : 1754,
    "minY" : 40,
    "maxY" : 898,
    "prop" : {
      "x" : 874,
      "y" : 111,
      "width" : 880,
      "height" : 787
    },
    "points" : [ {
      "x" : 456,
      "y" : 40
    }, {
      "x" : 1754,
      "y" : 40
    }, {
      "x" : 1754,
      "y" : 898
    }, {
      "x" : 456,
      "y" : 898
    } ],
    "colour" : "#008000"
  } ],
  "minX" : 0,
  "maxX" : 1825,
  "minY" : 0,
  "maxY" : 1228,
  "disease" : false
}