{
  "dbId" : 10225199,
  "stId" : "R-RNO-9018679",
  "speciesName" : "Rattus norvegicus",
  "nodes" : [ {
    "dbId" : 111745,
    "stId" : "R-ALL-111745",
    "displayName" : "GSSG [cytosol]",
    "schemaClass" : "SimpleEntity",
    "speciesId" : 0,
    "diagramIds" : [ 97984 ],
    "identifier" : "58297",
    "standardIdentifier" : "chebi:58297",
    "referenceType" : "ReferenceMolecule",
    "parents" : [ ],
    "children" : [ ]
  }, {
    "dbId" : 73473,
    "stId" : "R-ALL-73473",
    "displayName" : "NADH [cytosol]",
    "schemaClass" : "SimpleEntity",
    "speciesId" : 0,
    "diagramIds" : [ 98023 ],
    "identifier" : "57945",
    "standardIdentifier" : "chebi:57945",
    "referenceType" : "ReferenceMolecule",
    "parents" : [ ],
    "children" : [ ]
  }, {
    "dbId" : 9022921,
    "stId" : "R-ALL-9022921",
    "displayName" : "18(S)-HpEPE, 18(R)-HpEPE [cytosol]",
    "schemaClass" : "DefinedSet",
    "speciesId" : 0,
    "diagramIds" : [ 97979 ],
    "parents" : [ ],
    "children" : [ 9020583, 9023653 ]
  }, {
    "dbId" : 10164378,
    "stId" : "R-RNO-2142677",
    "displayName" : "HPGD [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48895,
    "identifier" : "O08699",
    "standardIdentifier" : "uniprot:O08699",
    "referenceType" : "ReferenceGeneProduct",
    "parents" : [ 10164380 ],
    "children" : [ ]
  }, {
    "dbId" : 10164380,
    "stId" : "R-RNO-2142778",
    "displayName" : "HPGD dimer [cytosol]",
    "schemaClass" : "Complex",
    "speciesId" : 48895,
    "diagramIds" : [ 98024 ],
    "parents" : [ ],
    "children" : [ 10164378 ]
  }, {
    "dbId" : 29450,
    "stId" : "R-ALL-29450",
    "displayName" : "GSH [cytosol]",
    "schemaClass" : "SimpleEntity",
    "speciesId" : 0,
    "diagramIds" : [ 97982 ],
    "identifier" : "57925",
    "standardIdentifier" : "chebi:57925",
    "referenceType" : "ReferenceMolecule",
    "parents" : [ ],
    "children" : [ ]
  }, {
    "dbId" : 9022660,
    "stId" : "R-ALL-9022660",
    "displayName" : "18(S)-RvE1 [cytosol]",
    "schemaClass" : "SimpleEntity",
    "speciesId" : 0,
    "diagramIds" : [ 98014 ],
    "identifier" : "136057",
    "standardIdentifier" : "chebi:136057",
    "referenceType" : "ReferenceMolecule",
    "parents" : [ ],
    "children" : [ ]
  }, {
    "dbId" : 10164489,
    "stId" : "R-RNO-2142838",
    "displayName" : "ALOX15 [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48895,
    "diagramIds" : [ 97995 ],
    "identifier" : "Q02759",
    "standardIdentifier" : "uniprot:Q02759",
    "referenceType" : "ReferenceGeneProduct",
    "parents" : [ ],
    "children" : [ ]
  }, {
    "dbId" : 9023963,
    "stId" : "R-ALL-9023963",
    "displayName" : "18-oxo-RvE1 [cytosol]",
    "schemaClass" : "SimpleEntity",
    "speciesId" : 0,
    "diagramIds" : [ 98022 ],
    "identifier" : "91001",
    "standardIdentifier" : "chebi:91001",
    "referenceType" : "ReferenceMolecule",
    "parents" : [ ],
    "children" : [ ]
  }, {
    "dbId" : 9023644,
    "stId" : "R-ALL-9023644",
    "displayName" : "(18R)-resolvin E3 [cytosol]",
    "schemaClass" : "SimpleEntity",
    "speciesId" : 0,
    "diagramIds" : [ 97994 ],
    "identifier" : "138542",
    "standardIdentifier" : "chebi:138542",
    "referenceType" : "ReferenceMolecule",
    "parents" : [ ],
    "children" : [ ]
  }, {
    "dbId" : 9023708,
    "stId" : "R-ALL-9023708",
    "displayName" : "5S,6S-epoxy-18(R)-HEPE [cytosol]",
    "schemaClass" : "SimpleEntity",
    "speciesId" : 0,
    "diagramIds" : [ 98011 ],
    "identifier" : "138563",
    "standardIdentifier" : "chebi:138563",
    "referenceType" : "ReferenceMolecule",
    "parents" : [ ],
    "children" : [ ]
  }, {
    "dbId" : 2311355,
    "stId" : "R-ALL-2311355",
    "displayName" : "heme b [endoplasmic reticulum membrane]",
    "schemaClass" : "SimpleEntity",
    "speciesId" : 0,
    "identifier" : "26355",
    "standardIdentifier" : "chebi:26355",
    "referenceType" : "ReferenceMolecule",
    "parents" : [ 10164463 ],
    "children" : [ ]
  }, {
    "dbId" : 10138758,
    "stId" : "R-RNO-429010",
    "displayName" : "ALOX5 [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48895,
    "diagramIds" : [ 98001, 98005 ],
    "identifier" : "P12527",
    "standardIdentifier" : "uniprot:P12527",
    "referenceType" : "ReferenceGeneProduct",
    "parents" : [ ],
    "children" : [ ]
  }, {
    "dbId" : 9022679,
    "stId" : "R-ALL-9022679",
    "displayName" : "18(S)-RvE3 [cytosol]",
    "schemaClass" : "SimpleEntity",
    "speciesId" : 0,
    "diagramIds" : [ 97997 ],
    "identifier" : "138477",
    "standardIdentifier" : "chebi:138477",
    "referenceType" : "ReferenceMolecule",
    "parents" : [ ],
    "children" : [ ]
  }, {
    "dbId" : 9023702,
    "stId" : "R-ALL-9023702",
    "displayName" : "5(S)-Hp-18(R)-HEPE [cytosol]",
    "schemaClass" : "SimpleEntity",
    "speciesId" : 0,
    "diagramIds" : [ 98004 ],
    "identifier" : "132218",
    "standardIdentifier" : "chebi:132218",
    "referenceType" : "ReferenceMolecule",
    "parents" : [ ],
    "children" : [ ]
  }, {
    "dbId" : 10209658,
    "stId" : "R-RNO-9020572",
    "displayName" : "Gpx4 [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48895,
    "diagramIds" : [ 97987 ],
    "identifier" : "P36970",
    "standardIdentifier" : "uniprot:P36970",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "Gpx4" ],
    "parents" : [ ],
    "children" : [ ]
  }, {
    "dbId" : 9023712,
    "stId" : "R-ALL-9023712",
    "displayName" : "18(R)-RvE1 [cytosol]",
    "schemaClass" : "SimpleEntity",
    "speciesId" : 0,
    "diagramIds" : [ 98018 ],
    "identifier" : "91000",
    "standardIdentifier" : "chebi:91000",
    "referenceType" : "ReferenceMolecule",
    "parents" : [ ],
    "children" : [ ]
  }, {
    "dbId" : 9023651,
    "stId" : "R-ALL-9023651",
    "displayName" : "18(R)-HEPE [cytosol]",
    "schemaClass" : "SimpleEntity",
    "speciesId" : 0,
    "diagramIds" : [ 97991 ],
    "identifier" : "90818",
    "standardIdentifier" : "chebi:90818",
    "referenceType" : "ReferenceMolecule",
    "parents" : [ ],
    "children" : [ ]
  }, {
    "dbId" : 29356,
    "stId" : "R-ALL-29356",
    "displayName" : "H2O [cytosol]",
    "schemaClass" : "SimpleEntity",
    "speciesId" : 0,
    "diagramIds" : [ 98017, 97986, 97990, 98013 ],
    "identifier" : "15377",
    "standardIdentifier" : "chebi:15377",
    "referenceType" : "ReferenceMolecule",
    "parents" : [ ],
    "children" : [ ]
  }, {
    "dbId" : 9023653,
    "stId" : "R-ALL-9023653",
    "displayName" : "18(R)-HpEPE [cytosol]",
    "schemaClass" : "SimpleEntity",
    "speciesId" : 0,
    "diagramIds" : [ 97989 ],
    "identifier" : "138565",
    "standardIdentifier" : "chebi:138565",
    "referenceType" : "ReferenceMolecule",
    "parents" : [ 9022921 ],
    "children" : [ ]
  }, {
    "dbId" : 9020583,
    "stId" : "R-ALL-9020583",
    "displayName" : "18(S)-HpEPE [cytosol]",
    "schemaClass" : "SimpleEntity",
    "speciesId" : 0,
    "diagramIds" : [ 97983 ],
    "identifier" : "138387",
    "standardIdentifier" : "chebi:138387",
    "referenceType" : "ReferenceMolecule",
    "parents" : [ 9022921 ],
    "children" : [ ]
  }, {
    "dbId" : 29360,
    "stId" : "R-ALL-29360",
    "displayName" : "NAD+ [cytosol]",
    "schemaClass" : "SimpleEntity",
    "speciesId" : 0,
    "diagramIds" : [ 98021 ],
    "identifier" : "57540",
    "standardIdentifier" : "chebi:57540",
    "referenceType" : "ReferenceMolecule",
    "parents" : [ ],
    "children" : [ ]
  }, {
    "dbId" : 10164459,
    "stId" : "R-RNO-2161824",
    "displayName" : "O-acetyl-L-serine-PTGS2 [endoplasmic reticulum membrane]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48895,
    "identifier" : "P35355",
    "standardIdentifier" : "uniprot:P35355",
    "referenceType" : "ReferenceGeneProduct",
    "parents" : [ 10164463 ],
    "children" : [ ]
  }, {
    "dbId" : 10129387,
    "stId" : "R-RNO-266038",
    "displayName" : "LTA4H:Zn2+ [cytosol]",
    "schemaClass" : "Complex",
    "speciesId" : 48895,
    "diagramIds" : [ 98019, 98015 ],
    "parents" : [ ],
    "children" : [ 10129385, 29426 ]
  }, {
    "dbId" : 29426,
    "stId" : "R-ALL-29426",
    "displayName" : "Zn2+ [cytosol]",
    "schemaClass" : "SimpleEntity",
    "speciesId" : 0,
    "identifier" : "29105",
    "standardIdentifier" : "chebi:29105",
    "referenceType" : "ReferenceMolecule",
    "parents" : [ 10129387 ],
    "children" : [ ]
  }, {
    "dbId" : 9020474,
    "stId" : "R-ALL-9020474",
    "displayName" : "18(S)-HEPE [cytosol]",
    "schemaClass" : "SimpleEntity",
    "speciesId" : 0,
    "diagramIds" : [ 97985 ],
    "identifier" : "132083",
    "standardIdentifier" : "chebi:132083",
    "referenceType" : "ReferenceMolecule",
    "parents" : [ ],
    "children" : [ ]
  }, {
    "dbId" : 9020602,
    "stId" : "R-ALL-9020602",
    "displayName" : "5(S)-Hp-18(S)-HEPE [cytosol]",
    "schemaClass" : "SimpleEntity",
    "speciesId" : 0,
    "diagramIds" : [ 98000 ],
    "identifier" : "132091",
    "standardIdentifier" : "chebi:132091",
    "referenceType" : "ReferenceMolecule",
    "parents" : [ ],
    "children" : [ ]
  }, {
    "dbId" : 10129385,
    "stId" : "R-RNO-266022",
    "displayName" : "LTA4H [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48895,
    "identifier" : "P30349",
    "standardIdentifier" : "uniprot:P30349",
    "referenceType" : "ReferenceGeneProduct",
    "parents" : [ 10129387 ],
    "children" : [ ]
  }, {
    "dbId" : 10164463,
    "stId" : "R-RNO-2314687",
    "displayName" : "Ac-PTGS2 dimer [endoplasmic reticulum membrane]",
    "schemaClass" : "Complex",
    "speciesId" : 48895,
    "diagramIds" : [ 97980 ],
    "parents" : [ ],
    "children" : [ 2311355, 10164461, 10164459 ]
  }, {
    "dbId" : 9022655,
    "stId" : "R-ALL-9022655",
    "displayName" : "5S,6S-epoxy-18(S)-HEPE [cytosol]",
    "schemaClass" : "SimpleEntity",
    "speciesId" : 0,
    "diagramIds" : [ 98008 ],
    "identifier" : "138490",
    "standardIdentifier" : "chebi:138490",
    "referenceType" : "ReferenceMolecule",
    "parents" : [ ],
    "children" : [ ]
  }, {
    "dbId" : 10164461,
    "stId" : "R-RNO-61605",
    "displayName" : "PTGS2 [endoplasmic reticulum membrane]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48895,
    "identifier" : "P35355",
    "standardIdentifier" : "uniprot:P35355",
    "referenceType" : "ReferenceGeneProduct",
    "parents" : [ 10164463 ],
    "children" : [ ]
  }, {
    "dbId" : 29368,
    "stId" : "R-ALL-29368",
    "displayName" : "O2 [cytosol]",
    "schemaClass" : "SimpleEntity",
    "speciesId" : 0,
    "diagramIds" : [ 98003, 98007, 97993, 97977, 98010, 97999 ],
    "identifier" : "15379",
    "standardIdentifier" : "chebi:15379",
    "referenceType" : "ReferenceMolecule",
    "parents" : [ ],
    "children" : [ ]
  }, {
    "dbId" : 2026977,
    "stId" : "R-ALL-2026977",
    "displayName" : "EPA [cytosol]",
    "schemaClass" : "SimpleEntity",
    "speciesId" : 0,
    "diagramIds" : [ 97978 ],
    "identifier" : "58562",
    "standardIdentifier" : "chebi:58562",
    "referenceType" : "ReferenceMolecule",
    "parents" : [ ],
    "children" : [ ]
  } ],
  "edges" : [ {
    "dbId" : 10209673,
    "stId" : "R-RNO-9018907",
    "displayName" : "ALOX15 oxidises 18(R)-HEPE to 18(R)-RvE3",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "preceding" : [ 10209670 ],
    "inputs" : [ 9023651, 29368 ],
    "outputs" : [ 9023644 ],
    "catalysts" : [ 10164489 ],
    "efs" : [ ],
    "diagramIds" : [ 97992 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10209656,
    "stId" : "R-RNO-9018863",
    "displayName" : "ALOX5 oxidises 18(R)-HEPE to 5(S)-Hp-18(R)-HEPE",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "preceding" : [ 10209670 ],
    "following" : [ 10209668 ],
    "inputs" : [ 9023651, 29368 ],
    "outputs" : [ 9023702 ],
    "catalysts" : [ 10138758 ],
    "efs" : [ ],
    "diagramIds" : [ 98002 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10209663,
    "stId" : "R-RNO-9018877",
    "displayName" : "LTA4H:Zn2+ hydrolyses 5S,6S-epoxy-18(R)-HEPE to 18(R)-RvE1",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "preceding" : [ 10209668 ],
    "inputs" : [ 29356, 9023708 ],
    "outputs" : [ 9023712 ],
    "catalysts" : [ 10129387 ],
    "efs" : [ ],
    "diagramIds" : [ 98016 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10209661,
    "stId" : "R-RNO-9018868",
    "displayName" : "GPX4-2 reduces 18(S)-HpEPE to 18(S)-HEPE",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "preceding" : [ 10209666 ],
    "following" : [ 10209713, 10209649 ],
    "inputs" : [ 9020583, 29450 ],
    "outputs" : [ 29356, 9020474, 111745 ],
    "catalysts" : [ 10209658 ],
    "efs" : [ ],
    "diagramIds" : [ 97981 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10209651,
    "stId" : "R-RNO-9018859",
    "displayName" : "ALOX5 oxidises 5(S)-Hp-18(S)-HEPE to 5S,6S-epoxy-18(S)-HEPE",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "preceding" : [ 10209649 ],
    "following" : [ 10209654 ],
    "inputs" : [ 29368, 9020602 ],
    "outputs" : [ 9022655 ],
    "catalysts" : [ 10138758 ],
    "efs" : [ ],
    "diagramIds" : [ 98006 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10209666,
    "stId" : "R-RNO-9018880",
    "displayName" : "Ac-PTGS2 dimer oxidises EPA to 18(R)-HpEPE or 18(S)-HpEPE",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "following" : [ 10209670, 10209661 ],
    "inputs" : [ 2026977, 29368 ],
    "outputs" : [ 9022921 ],
    "catalysts" : [ 10164463 ],
    "efs" : [ ],
    "diagramIds" : [ 97976 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10209713,
    "stId" : "R-RNO-9020610",
    "displayName" : "ALOX15 oxidises 18(S)-HEPE to 18(S)-RvE3",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "preceding" : [ 10209661 ],
    "inputs" : [ 29368, 9020474 ],
    "outputs" : [ 9022679 ],
    "catalysts" : [ 10164489 ],
    "efs" : [ ],
    "diagramIds" : [ 97996 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10209649,
    "stId" : "R-RNO-9018858",
    "displayName" : "ALOX5 oxidises 18(S)-HEPE to 5(S)-Hp-18(S)-HEPE",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "preceding" : [ 10209661 ],
    "following" : [ 10209651 ],
    "inputs" : [ 29368, 9020474 ],
    "outputs" : [ 9020602 ],
    "catalysts" : [ 10138758 ],
    "efs" : [ ],
    "diagramIds" : [ 97998 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10209654,
    "stId" : "R-RNO-9018862",
    "displayName" : "LTA4H:Zn2+ hydrolyses 5S,6S-epoxy-18(S)-HEPE to 18(S)-RvE1",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "preceding" : [ 10209651 ],
    "following" : [ 10209941 ],
    "inputs" : [ 29356, 9022655 ],
    "outputs" : [ 9022660 ],
    "catalysts" : [ 10129387 ],
    "efs" : [ ],
    "diagramIds" : [ 98012 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10209670,
    "stId" : "R-RNO-9018895",
    "displayName" : "GPX4-2 reduces 18(R)-HpEPE to 18(R)-HEPE",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "preceding" : [ 10209666 ],
    "following" : [ 10209673, 10209656 ],
    "inputs" : [ 9023653, 29450 ],
    "outputs" : [ 29356, 9023651, 111745 ],
    "catalysts" : [ 10209658 ],
    "efs" : [ ],
    "diagramIds" : [ 97988 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10209941,
    "stId" : "R-RNO-9023968",
    "displayName" : "HPGD dimer oxidises 18(S)-RvE1 to 18-oxo-RvE1",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "preceding" : [ 10209654 ],
    "inputs" : [ 9022660, 29360 ],
    "outputs" : [ 9023963, 73473 ],
    "catalysts" : [ 10164380 ],
    "efs" : [ ],
    "diagramIds" : [ 98020 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10209668,
    "stId" : "R-RNO-9018894",
    "displayName" : "ALOX5 oxidises 5(S)-Hp-18(R)-HEPE to 5S,6S-epoxy-18(R)-HEPE",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "preceding" : [ 10209656 ],
    "following" : [ 10209663 ],
    "inputs" : [ 9023702, 29368 ],
    "outputs" : [ 9023708 ],
    "catalysts" : [ 10138758 ],
    "efs" : [ ],
    "diagramIds" : [ 98009 ],
    "entityFunctionalStatus" : [ ]
  } ],
  "subpathways" : [ {
    "dbId" : 10225201,
    "stId" : "R-RNO-9023661",
    "displayName" : "Biosynthesis of E-series 18(R)-resolvins",
    "events" : [ 10209673, 10209656, 10209663, 10209670, 10209668 ]
  }, {
    "dbId" : 10225197,
    "stId" : "R-RNO-9018896",
    "displayName" : "Biosynthesis of E-series 18(S)-resolvins",
    "events" : [ 10209661, 10209651, 10209713, 10209649, 10209654, 10209941 ]
  } ]
}