{ "dbId" : 10223941, "stableId" : "R-RNO-512988", "displayName" : "Interleukin-3, Interleukin-5 and GM-CSF signaling", "nodes" : [ { "id" : 118529, "reactomeId" : 10144404, "displayName" : "High affinity binding complex dimers of cytokine receptors using Bc. activated JAK2:STAT5", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 103, "y" : 1122 }, "minX" : 38, "maxX" : 175, "minY" : 1081, "maxY" : 1225, "prop" : { "x" : 38, "y" : 1081, "width" : 131, "height" : 83 }, "textPosition" : { "x" : 36, "y" : 1084 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "connectors" : [ { "edgeId" : 118530, "type" : "INPUT", "segments" : [ { "from" : { "x" : 143, "y" : 1170 }, "to" : { "x" : 175, "y" : 1195 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 118530, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 104, "y" : 1170 }, "to" : { "x" : 106, "y" : 1221 } }, { "from" : { "x" : 106, "y" : 1221 }, "to" : { "x" : 159, "y" : 1221 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 163, "y" : 1221 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 163, "y" : 1221 } } }, { "edgeId" : 118527, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 118528, "reactomeId" : 10142170, "displayName" : "STAT5A,STAT5B", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 238, "y" : 1004 }, "minX" : 168, "maxX" : 280, "minY" : 987, "maxY" : 1040, "prop" : { "x" : 197, "y" : 987, "width" : 83, "height" : 34 }, "textPosition" : { "x" : 209, "y" : 987 }, "connectors" : [ { "edgeId" : 118527, "type" : "INPUT", "segments" : [ { "from" : { "x" : 204, "y" : 1027 }, "to" : { "x" : 168, "y" : 1040 } } ], "stoichiometry" : { "value" : 3, "shape" : { "a" : { "x" : 180, "y" : 1027 }, "b" : { "x" : 192, "y" : 1039 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 186, "y" : 1033 } } } } ] }, { "id" : 118531, "reactomeId" : 113592, "displayName" : "ATP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 222, "y" : 1158 }, "minX" : 175, "maxX" : 244, "minY" : 1142, "maxY" : 1195, "prop" : { "x" : 201, "y" : 1143, "width" : 42, "height" : 31 }, "textPosition" : { "x" : 206, "y" : 1148 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 238, "y" : 1148 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 238, "y" : 1148 } } }, "connectors" : [ { "edgeId" : 118530, "type" : "INPUT", "segments" : [ { "from" : { "x" : 202, "y" : 1177 }, "to" : { "x" : 175, "y" : 1195 } } ], "stoichiometry" : { "value" : 6, "shape" : { "a" : { "x" : 182, "y" : 1180 }, "b" : { "x" : 194, "y" : 1192 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 188, "y" : 1186 } } } } ] }, { "id" : 118533, "reactomeId" : 10144412, "displayName" : "High affinity binding complex dimers of cytokine receptors using Bc, activated JAK2:p-STAT5", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 95, "y" : 1343 }, "minX" : 30, "maxX" : 176, "minY" : 1248, "maxY" : 1385, "prop" : { "x" : 30, "y" : 1302, "width" : 131, "height" : 83 }, "textPosition" : { "x" : 28, "y" : 1305 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "connectors" : [ { "edgeId" : 118530, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 130, "y" : 1296 }, "to" : { "x" : 176, "y" : 1248 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 132, "y" : 1288 }, "b" : { "x" : 130, "y" : 1296 }, "c" : { "x" : 138, "y" : 1294 }, "type" : "ARROW", "centre" : { "x" : 138, "y" : 1294 } } }, { "edgeId" : 118534, "type" : "INPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 118532, "reactomeId" : 29370, "displayName" : "ADP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 228, "y" : 1280 }, "minX" : 176, "maxX" : 250, "minY" : 1248, "maxY" : 1296, "prop" : { "x" : 207, "y" : 1265, "width" : 42, "height" : 31 }, "textPosition" : { "x" : 211, "y" : 1270 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 244, "y" : 1270 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 244, "y" : 1270 } } }, "connectors" : [ { "edgeId" : 118530, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 204, "y" : 1267 }, "to" : { "x" : 176, "y" : 1248 } } ], "stoichiometry" : { "value" : 6, "shape" : { "a" : { "x" : 184, "y" : 1251 }, "b" : { "x" : 196, "y" : 1263 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 190, "y" : 1257 } } }, "endShape" : { "a" : { "x" : 196, "y" : 1266 }, "b" : { "x" : 204, "y" : 1267 }, "c" : { "x" : 201, "y" : 1260 }, "type" : "ARROW", "centre" : { "x" : 201, "y" : 1260 } } } ] }, { "id" : 118535, "reactomeId" : 10142179, "displayName" : "p-STAT5A, p-STAT5B", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 219, "y" : 1340 }, "minX" : 4, "maxX" : 262, "minY" : 1155, "maxY" : 1355, "prop" : { "x" : 176, "y" : 1325, "width" : 86, "height" : 30 }, "textPosition" : { "x" : 176, "y" : 1323 }, "connectors" : [ { "edgeId" : 118534, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 201, "y" : 1319 }, "to" : { "x" : 4, "y" : 1155 } } ], "stoichiometry" : { "value" : 3, "shape" : { "a" : { "x" : 96, "y" : 1231 }, "b" : { "x" : 108, "y" : 1243 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 102, "y" : 1237 } } }, "endShape" : { "a" : { "x" : 193, "y" : 1318 }, "b" : { "x" : 201, "y" : 1319 }, "c" : { "x" : 198, "y" : 1311 }, "type" : "ARROW", "centre" : { "x" : 198, "y" : 1311 } } } ] }, { "id" : 118537, "reactomeId" : 113592, "displayName" : "ATP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1440, "y" : 175 }, "minX" : 1419, "maxX" : 1495, "minY" : 159, "maxY" : 207, "prop" : { "x" : 1419, "y" : 160, "width" : 42, "height" : 31 }, "textPosition" : { "x" : 1424, "y" : 165 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1456, "y" : 165 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1456, "y" : 165 } } }, "connectors" : [ { "edgeId" : 118536, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1464, "y" : 187 }, "to" : { "x" : 1495, "y" : 207 } } ], "stoichiometry" : { "value" : 12, "shape" : { "a" : { "x" : 1473, "y" : 191 }, "b" : { "x" : 1485, "y" : 203 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1479, "y" : 197 } } } } ] }, { "id" : 118539, "reactomeId" : 29370, "displayName" : "ADP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1453, "y" : 317 }, "minX" : 1432, "maxX" : 1495, "minY" : 260, "maxY" : 333, "prop" : { "x" : 1432, "y" : 302, "width" : 42, "height" : 31 }, "textPosition" : { "x" : 1436, "y" : 307 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1469, "y" : 307 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1469, "y" : 307 } } }, "connectors" : [ { "edgeId" : 118536, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 1464, "y" : 299 }, "to" : { "x" : 1495, "y" : 260 } } ], "stoichiometry" : { "value" : 12, "shape" : { "a" : { "x" : 1473, "y" : 273 }, "b" : { "x" : 1485, "y" : 285 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1479, "y" : 279 } } }, "endShape" : { "a" : { "x" : 1465, "y" : 291 }, "b" : { "x" : 1464, "y" : 299 }, "c" : { "x" : 1471, "y" : 296 }, "type" : "ARROW", "centre" : { "x" : 1471, "y" : 296 } } } ] }, { "id" : 118538, "reactomeId" : 10144377, "displayName" : "High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(Y593,628)-Bc", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 1609, "y" : 303 }, "minX" : 355, "maxX" : 1692, "minY" : 260, "maxY" : 1443, "prop" : { "x" : 1527, "y" : 264, "width" : 165, "height" : 78 }, "textPosition" : { "x" : 1526, "y" : 264 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "connectors" : [ { "edgeId" : 118536, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 1521, "y" : 271 }, "to" : { "x" : 1495, "y" : 260 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1513, "y" : 272 }, "b" : { "x" : 1521, "y" : 271 }, "c" : { "x" : 1516, "y" : 265 }, "type" : "ARROW", "centre" : { "x" : 1516, "y" : 265 } } }, { "edgeId" : 118541, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1584, "y" : 348 }, "to" : { "x" : 1569, "y" : 367 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 118565, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1521, "y" : 334 }, "to" : { "x" : 541, "y" : 712 } }, { "from" : { "x" : 541, "y" : 712 }, "to" : { "x" : 545, "y" : 1335 } }, { "from" : { "x" : 545, "y" : 1335 }, "to" : { "x" : 355, "y" : 1443 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 118540, "reactomeId" : 10144389, "displayName" : "Tyrosine kinases that phosphorylate the Common beta chain", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 1589, "y" : 163 }, "minX" : 1504, "maxX" : 1656, "minY" : 131, "maxY" : 235, "prop" : { "x" : 1523, "y" : 131, "width" : 133, "height" : 64 }, "textPosition" : { "x" : 1523, "y" : 131 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "connectors" : [ { "edgeId" : 118536, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 1562, "y" : 201 }, "to" : { "x" : 1533, "y" : 230 } }, { "from" : { "x" : 1533, "y" : 230 }, "to" : { "x" : 1512, "y" : 231 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 1508, "y" : 231 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1508, "y" : 231 } } } ] }, { "id" : 118543, "reactomeId" : 10144444, "displayName" : "High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(Y593,628)-Bc:SHC1", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 1591, "y" : 490 }, "minX" : 1526, "maxX" : 1657, "minY" : 441, "maxY" : 539, "prop" : { "x" : 1526, "y" : 441, "width" : 131, "height" : 98 }, "textPosition" : { "x" : 1524, "y" : 444 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "connectors" : [ { "edgeId" : 118541, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 118542, "reactomeId" : 10108630, "displayName" : "Shc1", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 1508, "y" : 387 }, "minX" : 1484, "maxX" : 1569, "minY" : 366, "maxY" : 402, "prop" : { "x" : 1484, "y" : 373, "width" : 49, "height" : 29 }, "textPosition" : { "x" : 1489, "y" : 377 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1533, "y" : 373 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1533, "y" : 373 } } }, "connectors" : [ { "edgeId" : 118541, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1536, "y" : 378 }, "to" : { "x" : 1569, "y" : 367 } } ], "stoichiometry" : { "value" : 3, "shape" : { "a" : { "x" : 1546, "y" : 366 }, "b" : { "x" : 1558, "y" : 378 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1552, "y" : 372 } } } } ] }, { "id" : 118545, "reactomeId" : 10142261, "displayName" : "GRB2:GAB2", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 1437, "y" : 817 }, "minX" : 1409, "maxX" : 1586, "minY" : 790, "maxY" : 838, "prop" : { "x" : 1409, "y" : 796, "width" : 57, "height" : 42 }, "textPosition" : { "x" : 1415, "y" : 803 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1466, "y" : 796 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1466, "y" : 796 } } }, "connectors" : [ { "edgeId" : 118544, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1469, "y" : 817 }, "to" : { "x" : 1586, "y" : 822 } } ], "stoichiometry" : { "value" : 4, "shape" : { "a" : { "x" : 1521, "y" : 813 }, "b" : { "x" : 1533, "y" : 825 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1527, "y" : 819 } } } } ] }, { "id" : 118547, "reactomeId" : 10142283, "displayName" : "Interleukin receptor compexes with activated Shc:GRB2:GAB2", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 1631, "y" : 894 }, "minX" : 1555, "maxX" : 1708, "minY" : 862, "maxY" : 959, "prop" : { "x" : 1555, "y" : 862, "width" : 153, "height" : 64 }, "textPosition" : { "x" : 1563, "y" : 862 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "connectors" : [ { "edgeId" : 118544, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 118548, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1612, "y" : 932 }, "to" : { "x" : 1594, "y" : 959 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 118546, "reactomeId" : 10142259, "displayName" : "Interleukin receptor complexes with activated SHC1", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 1603, "y" : 765 }, "minX" : 1233, "maxX" : 1666, "minY" : 733, "maxY" : 1197, "prop" : { "x" : 1541, "y" : 733, "width" : 125, "height" : 64 }, "textPosition" : { "x" : 1550, "y" : 733 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "connectors" : [ { "edgeId" : 118544, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1593, "y" : 803 }, "to" : { "x" : 1586, "y" : 822 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 118555, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1587, "y" : 803 }, "to" : { "x" : 1388, "y" : 1197 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 118558, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1565, "y" : 803 }, "to" : { "x" : 1233, "y" : 1083 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 118549, "reactomeId" : 113592, "displayName" : "ATP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1530, "y" : 960 }, "minX" : 1511, "maxX" : 1594, "minY" : 944, "maxY" : 976, "prop" : { "x" : 1511, "y" : 945, "width" : 38, "height" : 31 }, "textPosition" : { "x" : 1514, "y" : 950 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1544, "y" : 950 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1544, "y" : 950 } } }, "connectors" : [ { "edgeId" : 118548, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1552, "y" : 959 }, "to" : { "x" : 1594, "y" : 959 } } ], "stoichiometry" : { "value" : 4, "shape" : { "a" : { "x" : 1567, "y" : 953 }, "b" : { "x" : 1579, "y" : 965 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1573, "y" : 959 } } } } ] }, { "id" : 118551, "reactomeId" : 29370, "displayName" : "ADP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1530, "y" : 999 }, "minX" : 1511, "maxX" : 1594, "minY" : 983, "maxY" : 1015, "prop" : { "x" : 1511, "y" : 984, "width" : 39, "height" : 31 }, "textPosition" : { "x" : 1514, "y" : 989 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1545, "y" : 989 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1545, "y" : 989 } } }, "connectors" : [ { "edgeId" : 118548, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 1553, "y" : 998 }, "to" : { "x" : 1594, "y" : 998 } } ], "stoichiometry" : { "value" : 4, "shape" : { "a" : { "x" : 1567, "y" : 992 }, "b" : { "x" : 1579, "y" : 1004 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1573, "y" : 998 } } }, "endShape" : { "a" : { "x" : 1560, "y" : 994 }, "b" : { "x" : 1553, "y" : 998 }, "c" : { "x" : 1560, "y" : 1002 }, "type" : "ARROW", "centre" : { "x" : 1560, "y" : 1002 } } } ] }, { "id" : 118550, "reactomeId" : 10143225, "displayName" : "Interleukin receptor complexes with activated Shc:GRB2:p-GAB2", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 1617, "y" : 1052 }, "minX" : 1541, "maxX" : 1694, "minY" : 998, "maxY" : 1110, "prop" : { "x" : 1541, "y" : 1020, "width" : 153, "height" : 64 }, "textPosition" : { "x" : 1544, "y" : 1020 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "connectors" : [ { "edgeId" : 118548, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 1603, "y" : 1014 }, "to" : { "x" : 1594, "y" : 998 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1596, "y" : 1010 }, "b" : { "x" : 1603, "y" : 1014 }, "c" : { "x" : 1603, "y" : 1006 }, "type" : "ARROW", "centre" : { "x" : 1603, "y" : 1006 } } }, { "edgeId" : 118552, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1602, "y" : 1090 }, "to" : { "x" : 1591, "y" : 1110 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 118553, "reactomeId" : 10143211, "displayName" : "p85-containing Class 1A PI3Ks", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 1061, "y" : 929 }, "minX" : 206, "maxX" : 1591, "minY" : 362, "maxY" : 1625, "prop" : { "x" : 1008, "y" : 911, "width" : 107, "height" : 36 }, "textPosition" : { "x" : 1008, "y" : 911 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "connectors" : [ { "edgeId" : 118552, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1113, "y" : 953 }, "to" : { "x" : 1591, "y" : 1110 } } ], "stoichiometry" : { "value" : 4, "shape" : { "a" : { "x" : 1346, "y" : 1025 }, "b" : { "x" : 1358, "y" : 1037 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1352, "y" : 1031 } } } }, { "edgeId" : 118580, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1033, "y" : 905 }, "to" : { "x" : 206, "y" : 362 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 118582, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1048, "y" : 953 }, "to" : { "x" : 565, "y" : 1625 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 118554, "reactomeId" : 10143237, "displayName" : "Interleukin receptor complexes with activated Shc:GRB2:p-GAB2:p85-containing Class 1 PI3Ks", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 1594, "y" : 1233 }, "minX" : 1532, "maxX" : 1657, "minY" : 1184, "maxY" : 1282, "prop" : { "x" : 1532, "y" : 1184, "width" : 125, "height" : 98 }, "textPosition" : { "x" : 1531, "y" : 1181 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "connectors" : [ { "edgeId" : 118552, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 118557, "reactomeId" : 10142287, "displayName" : "Interleukin receptor complexes with activated SHC1:GRB2:SOS1", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 1592, "y" : 1376 }, "minX" : 1531, "maxX" : 1660, "minY" : 1335, "maxY" : 1411, "prop" : { "x" : 1531, "y" : 1341, "width" : 123, "height" : 70 }, "textPosition" : { "x" : 1539, "y" : 1334 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1654, "y" : 1341 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1654, "y" : 1341 } } }, "connectors" : [ { "edgeId" : 118555, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 118556, "reactomeId" : 10108599, "displayName" : "GRB2-1:SOS1", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 1319, "y" : 1146 }, "minX" : 1268, "maxX" : 1388, "minY" : 1126, "maxY" : 1197, "prop" : { "x" : 1268, "y" : 1132, "width" : 103, "height" : 29 }, "textPosition" : { "x" : 1274, "y" : 1140 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1371, "y" : 1132 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1371, "y" : 1132 } } }, "connectors" : [ { "edgeId" : 118555, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1338, "y" : 1164 }, "to" : { "x" : 1388, "y" : 1197 } } ], "stoichiometry" : { "value" : 4, "shape" : { "a" : { "x" : 1357, "y" : 1174 }, "b" : { "x" : 1369, "y" : 1186 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1363, "y" : 1180 } } } } ] }, { "id" : 118559, "reactomeId" : 10144966, "displayName" : "SHIP1,2", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 1170, "y" : 1018 }, "minX" : 1142, "maxX" : 1233, "minY" : 1007, "maxY" : 1083, "prop" : { "x" : 1142, "y" : 1007, "width" : 56, "height" : 23 }, "textPosition" : { "x" : 1142, "y" : 1008 }, "connectors" : [ { "edgeId" : 118558, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1181, "y" : 1036 }, "to" : { "x" : 1233, "y" : 1083 } } ], "stoichiometry" : { "value" : 4, "shape" : { "a" : { "x" : 1201, "y" : 1053 }, "b" : { "x" : 1213, "y" : 1065 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1207, "y" : 1059 } } } } ] }, { "id" : 118560, "reactomeId" : 10144968, "displayName" : "Interleukin receptor complexes with activated SHC1:SHIP1,2", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 1322, "y" : 1891 }, "minX" : 1260, "maxX" : 1391, "minY" : 1846, "maxY" : 1930, "prop" : { "x" : 1260, "y" : 1852, "width" : 125, "height" : 78 }, "textPosition" : { "x" : 1269, "y" : 1853 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1385, "y" : 1852 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1385, "y" : 1852 } } }, "connectors" : [ { "edgeId" : 118558, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 118563, "reactomeId" : 10144972, "displayName" : "Interleukin receptor complexes with activated SHC1:SHIP1", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 402, "y" : 1895 }, "minX" : 339, "maxX" : 495, "minY" : 1853, "maxY" : 1931, "prop" : { "x" : 339, "y" : 1859, "width" : 126, "height" : 72 }, "textPosition" : { "x" : 348, "y" : 1854 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 465, "y" : 1859 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 465, "y" : 1859 } } }, "connectors" : [ { "edgeId" : 118561, "type" : "INPUT", "segments" : [ { "from" : { "x" : 468, "y" : 1883 }, "to" : { "x" : 495, "y" : 1878 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 118562, "reactomeId" : 10108594, "displayName" : "Grb2", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 442, "y" : 1801 }, "minX" : 409, "maxX" : 565, "minY" : 1625, "maxY" : 1878, "prop" : { "x" : 409, "y" : 1790, "width" : 66, "height" : 22 }, "textPosition" : { "x" : 423, "y" : 1790 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 475, "y" : 1790 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 475, "y" : 1790 } } }, "connectors" : [ { "edgeId" : 118561, "type" : "INPUT", "segments" : [ { "from" : { "x" : 449, "y" : 1815 }, "to" : { "x" : 495, "y" : 1878 } } ], "stoichiometry" : { "value" : 4, "shape" : { "a" : { "x" : 466, "y" : 1840 }, "b" : { "x" : 478, "y" : 1852 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 472, "y" : 1846 } } } }, { "edgeId" : 118582, "type" : "INPUT", "segments" : [ { "from" : { "x" : 449, "y" : 1787 }, "to" : { "x" : 565, "y" : 1625 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 118564, "reactomeId" : 10144974, "displayName" : "Interleukin receptor complexes with activated SHC1:SHIP:GRB2", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 631, "y" : 1898 }, "minX" : 569, "maxX" : 700, "minY" : 1859, "maxY" : 1931, "prop" : { "x" : 569, "y" : 1865, "width" : 125, "height" : 66 }, "textPosition" : { "x" : 578, "y" : 1854 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 694, "y" : 1865 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 694, "y" : 1865 } } }, "connectors" : [ { "edgeId" : 118561, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 118567, "reactomeId" : 10144837, "displayName" : "High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2,p(Y593,628)-Bc:SHP1, SHP2", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 80, "y" : 1485 }, "minX" : 15, "maxX" : 152, "minY" : 1430, "maxY" : 1587, "prop" : { "x" : 15, "y" : 1436, "width" : 131, "height" : 98 }, "textPosition" : { "x" : 13, "y" : 1443 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 146, "y" : 1436 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 146, "y" : 1436 } } }, "connectors" : [ { "edgeId" : 118565, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 118568, "type" : "INPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 118568, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 54, "y" : 1537 }, "to" : { "x" : 29, "y" : 1582 } }, { "from" : { "x" : 29, "y" : 1582 }, "to" : { "x" : 63, "y" : 1583 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 67, "y" : 1583 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 67, "y" : 1583 } } } ] }, { "id" : 118566, "reactomeId" : 10134831, "displayName" : "PTPN6,PTPN11", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 398, "y" : 1496 }, "minX" : 352, "maxX" : 444, "minY" : 1443, "maxY" : 1511, "prop" : { "x" : 352, "y" : 1482, "width" : 92, "height" : 29 }, "textPosition" : { "x" : 370, "y" : 1479 }, "connectors" : [ { "edgeId" : 118565, "type" : "INPUT", "segments" : [ { "from" : { "x" : 386, "y" : 1476 }, "to" : { "x" : 355, "y" : 1443 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 118569, "reactomeId" : 10145493, "displayName" : "High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2,p(Y593)-Bc:SHP1, SHP2", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 81, "y" : 1665 }, "minX" : 16, "maxX" : 153, "minY" : 1610, "maxY" : 1714, "prop" : { "x" : 16, "y" : 1616, "width" : 131, "height" : 98 }, "textPosition" : { "x" : 14, "y" : 1623 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 147, "y" : 1616 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 147, "y" : 1616 } } }, "connectors" : [ { "edgeId" : 118568, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 118571, "reactomeId" : 10144954, "displayName" : "High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(S589)-Bc", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 95, "y" : 530 }, "minX" : 30, "maxX" : 201, "minY" : 482, "maxY" : 572, "prop" : { "x" : 30, "y" : 489, "width" : 131, "height" : 83 }, "textPosition" : { "x" : 28, "y" : 492 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "connectors" : [ { "edgeId" : 118570, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 118573, "type" : "INPUT", "segments" : [ { "from" : { "x" : 167, "y" : 500 }, "to" : { "x" : 201, "y" : 482 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 118572, "reactomeId" : 10112073, "displayName" : "PRKACA", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 283, "y" : 641 }, "minX" : 213, "maxX" : 317, "minY" : 624, "maxY" : 652, "prop" : { "x" : 255, "y" : 630, "width" : 56, "height" : 22 }, "textPosition" : { "x" : 255, "y" : 630 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 311, "y" : 630 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 311, "y" : 630 } } }, "connectors" : [ { "edgeId" : 118570, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 252, "y" : 642 }, "to" : { "x" : 221, "y" : 643 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 217, "y" : 643 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 217, "y" : 643 } } } ] }, { "id" : 118575, "reactomeId" : 10144956, "displayName" : "High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(S589)-Bc:14-3-3 zeta", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 95, "y" : 424 }, "minX" : 30, "maxX" : 206, "minY" : 362, "maxY" : 473, "prop" : { "x" : 30, "y" : 375, "width" : 131, "height" : 98 }, "textPosition" : { "x" : 28, "y" : 382 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 161, "y" : 375 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 161, "y" : 375 } } }, "connectors" : [ { "edgeId" : 118573, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 118580, "type" : "INPUT", "segments" : [ { "from" : { "x" : 164, "y" : 387 }, "to" : { "x" : 206, "y" : 362 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 118574, "reactomeId" : 10108837, "displayName" : "Ywhaz", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 263, "y" : 510 }, "minX" : 201, "maxX" : 307, "minY" : 482, "maxY" : 526, "prop" : { "x" : 225, "y" : 495, "width" : 76, "height" : 31 }, "textPosition" : { "x" : 240, "y" : 500 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 301, "y" : 495 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 301, "y" : 495 } } }, "connectors" : [ { "edgeId" : 118573, "type" : "INPUT", "segments" : [ { "from" : { "x" : 228, "y" : 492 }, "to" : { "x" : 201, "y" : 482 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 118577, "reactomeId" : 10127083, "displayName" : "Vav1", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 797, "y" : 1768 }, "minX" : 771, "maxX" : 830, "minY" : 1724, "maxY" : 1808, "prop" : { "x" : 777, "y" : 1757, "width" : 41, "height" : 23 }, "textPosition" : { "x" : 778, "y" : 1758 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 818, "y" : 1757 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 818, "y" : 1757 } } }, "connectors" : [ { "edgeId" : 118576, "type" : "INPUT", "segments" : [ { "from" : { "x" : 789, "y" : 1783 }, "to" : { "x" : 771, "y" : 1808 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 118586, "type" : "INPUT", "segments" : [ { "from" : { "x" : 805, "y" : 1754 }, "to" : { "x" : 830, "y" : 1724 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 118579, "reactomeId" : 10144422, "displayName" : "TEC:VAV1", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 773, "y" : 1870 }, "minX" : 738, "maxX" : 815, "minY" : 1853, "maxY" : 1882, "prop" : { "x" : 738, "y" : 1859, "width" : 71, "height" : 23 }, "textPosition" : { "x" : 740, "y" : 1861 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 809, "y" : 1859 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 809, "y" : 1859 } } }, "connectors" : [ { "edgeId" : 118576, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 118578, "reactomeId" : 10127427, "displayName" : "TEC", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 744, "y" : 1768 }, "minX" : 727, "maxX" : 771, "minY" : 1751, "maxY" : 1808, "prop" : { "x" : 727, "y" : 1757, "width" : 34, "height" : 23 }, "textPosition" : { "x" : 728, "y" : 1758 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 761, "y" : 1757 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 761, "y" : 1757 } } }, "connectors" : [ { "edgeId" : 118576, "type" : "INPUT", "segments" : [ { "from" : { "x" : 751, "y" : 1783 }, "to" : { "x" : 771, "y" : 1808 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 118581, "reactomeId" : 10145498, "displayName" : "High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(S589)-Bc:14-3-3 zeta:p85-containing Class 1A PI3Ks", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 104, "y" : 301 }, "minX" : 30, "maxX" : 185, "minY" : 238, "maxY" : 358, "prop" : { "x" : 30, "y" : 244, "width" : 149, "height" : 114 }, "textPosition" : { "x" : 30, "y" : 253 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 179, "y" : 244 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 179, "y" : 244 } } }, "connectors" : [ { "edgeId" : 118580, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 118583, "reactomeId" : 10144432, "displayName" : "FYN-like kinases", "schemaClass" : "CandidateSet", "renderableClass" : "EntitySet", "position" : { "x" : 462, "y" : 1631 }, "minX" : 412, "maxX" : 565, "minY" : 1615, "maxY" : 1648, "prop" : { "x" : 412, "y" : 1615, "width" : 101, "height" : 33 }, "textPosition" : { "x" : 432, "y" : 1614 }, "connectors" : [ { "edgeId" : 118582, "type" : "INPUT", "segments" : [ { "from" : { "x" : 519, "y" : 1628 }, "to" : { "x" : 565, "y" : 1625 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 118585, "reactomeId" : 10144434, "displayName" : "FYN-like kinases:CBL:GRB2:p85-containing Class 1A PI3Ks", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 717, "y" : 1287 }, "minX" : 657, "maxX" : 784, "minY" : 1247, "maxY" : 1321, "prop" : { "x" : 657, "y" : 1253, "width" : 121, "height" : 68 }, "textPosition" : { "x" : 660, "y" : 1258 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 778, "y" : 1253 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 778, "y" : 1253 } } }, "connectors" : [ { "edgeId" : 118582, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 118584, "reactomeId" : 10120485, "displayName" : "Cbl", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 561, "y" : 1714 }, "minX" : 538, "maxX" : 591, "minY" : 1625, "maxY" : 1725, "prop" : { "x" : 538, "y" : 1704, "width" : 47, "height" : 21 }, "textPosition" : { "x" : 548, "y" : 1704 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 585, "y" : 1704 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 585, "y" : 1704 } } }, "connectors" : [ { "edgeId" : 118582, "type" : "INPUT", "segments" : [ { "from" : { "x" : 561, "y" : 1701 }, "to" : { "x" : 565, "y" : 1625 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 118587, "reactomeId" : 10144846, "displayName" : "phospho-Cbl", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 676, "y" : 1641 }, "minX" : 619, "maxX" : 830, "minY" : 1533, "maxY" : 1724, "prop" : { "x" : 619, "y" : 1616, "width" : 114, "height" : 50 }, "textPosition" : { "x" : 633, "y" : 1630 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 733, "y" : 1616 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 733, "y" : 1616 } } }, "connectors" : [ { "edgeId" : 118593, "type" : "INPUT", "segments" : [ { "from" : { "x" : 704, "y" : 1613 }, "to" : { "x" : 798, "y" : 1533 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 118586, "type" : "INPUT", "segments" : [ { "from" : { "x" : 722, "y" : 1669 }, "to" : { "x" : 830, "y" : 1724 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 118588, "reactomeId" : 10144927, "displayName" : "p(Y700,731,774)-CBL:VAV1", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 966, "y" : 1725 }, "minX" : 903, "maxX" : 1035, "minY" : 1700, "maxY" : 1744, "prop" : { "x" : 903, "y" : 1706, "width" : 126, "height" : 38 }, "textPosition" : { "x" : 907, "y" : 1709 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1029, "y" : 1706 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1029, "y" : 1706 } } }, "connectors" : [ { "edgeId" : 118586, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 118591, "reactomeId" : 10144894, "displayName" : "K48polyUb", "schemaClass" : "Polymer", "renderableClass" : "Entity", "position" : { "x" : 614, "y" : 1073 }, "minX" : 554, "maxX" : 683, "minY" : 1036, "maxY" : 1088, "prop" : { "x" : 554, "y" : 1059, "width" : 120, "height" : 29 }, "textPosition" : { "x" : 577, "y" : 1063 }, "connectors" : [ { "edgeId" : 118589, "type" : "INPUT", "segments" : [ { "from" : { "x" : 641, "y" : 1056 }, "to" : { "x" : 683, "y" : 1036 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 118590, "reactomeId" : 10144848, "displayName" : "FYN-like kinases:p(Y731)-CBL:GRB2:p85-containing Class 1A PI3Ks", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 783, "y" : 1083 }, "minX" : 683, "maxX" : 852, "minY" : 1036, "maxY" : 1117, "prop" : { "x" : 720, "y" : 1049, "width" : 126, "height" : 68 }, "textPosition" : { "x" : 723, "y" : 1054 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 846, "y" : 1049 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 846, "y" : 1049 } } }, "connectors" : [ { "edgeId" : 118589, "type" : "INPUT", "segments" : [ { "from" : { "x" : 717, "y" : 1053 }, "to" : { "x" : 683, "y" : 1036 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 118592, "reactomeId" : 10144915, "displayName" : "FYN-like kinases:p(Y731)-CBL:GRB2:Ubiquitinated p85-containing Class 1A PI3Ks", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 681, "y" : 906 }, "minX" : 621, "maxX" : 748, "minY" : 859, "maxY" : 948, "prop" : { "x" : 621, "y" : 865, "width" : 121, "height" : 83 }, "textPosition" : { "x" : 621, "y" : 871 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 742, "y" : 865 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 742, "y" : 865 } } }, "connectors" : [ { "edgeId" : 118589, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 118595, "reactomeId" : 10144931, "displayName" : "p(Y700,731,774)-CBL:CRK", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 995, "y" : 1532 }, "minX" : 932, "maxX" : 1068, "minY" : 1479, "maxY" : 1551, "prop" : { "x" : 932, "y" : 1513, "width" : 126, "height" : 38 }, "textPosition" : { "x" : 936, "y" : 1516 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1058, "y" : 1513 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1058, "y" : 1513 } } }, "connectors" : [ { "edgeId" : 118593, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 118596, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1021, "y" : 1510 }, "to" : { "x" : 1068, "y" : 1479 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 118594, "reactomeId" : 10134149, "displayName" : "CRK, CRKL", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 743, "y" : 1504 }, "minX" : 708, "maxX" : 798, "minY" : 1493, "maxY" : 1533, "prop" : { "x" : 708, "y" : 1493, "width" : 71, "height" : 22 }, "textPosition" : { "x" : 709, "y" : 1493 }, "connectors" : [ { "edgeId" : 118593, "type" : "INPUT", "segments" : [ { "from" : { "x" : 763, "y" : 1521 }, "to" : { "x" : 798, "y" : 1533 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 118597, "reactomeId" : 10118073, "displayName" : "Rapgef1", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 1003, "y" : 1458 }, "minX" : 971, "maxX" : 1068, "minY" : 1441, "maxY" : 1479, "prop" : { "x" : 971, "y" : 1447, "width" : 65, "height" : 22 }, "textPosition" : { "x" : 973, "y" : 1447 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1036, "y" : 1447 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1036, "y" : 1447 } } }, "connectors" : [ { "edgeId" : 118596, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1039, "y" : 1468 }, "to" : { "x" : 1068, "y" : 1479 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 118598, "reactomeId" : 10144933, "displayName" : "p(Y700,731,774)-CBL:CRK:RAPGEF1", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 1202, "y" : 1482 }, "minX" : 1139, "maxX" : 1271, "minY" : 1457, "maxY" : 1501, "prop" : { "x" : 1139, "y" : 1463, "width" : 126, "height" : 38 }, "textPosition" : { "x" : 1143, "y" : 1466 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1265, "y" : 1463 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1265, "y" : 1463 } } }, "connectors" : [ { "edgeId" : 118596, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 118606, "reactomeId" : 10144367, "displayName" : "GM-CSF:GM-CSF receptor alpha subunit:Common beta chain:JAK2", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 1310, "y" : 89 }, "minX" : 1253, "maxX" : 1374, "minY" : 49, "maxY" : 123, "prop" : { "x" : 1253, "y" : 55, "width" : 115, "height" : 68 }, "textPosition" : { "x" : 1252, "y" : 60 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1368, "y" : 55 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1368, "y" : 55 } } }, "connectors" : [ ] }, { "id" : 118609, "reactomeId" : 10144371, "displayName" : "IL5 homodimer:IL5RA:Common beta chain:JAK2", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 1490, "y" : 85 }, "minX" : 1437, "maxX" : 1549, "minY" : 53, "maxY" : 112, "prop" : { "x" : 1437, "y" : 59, "width" : 106, "height" : 53 }, "textPosition" : { "x" : 1437, "y" : 63 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1543, "y" : 59 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1543, "y" : 59 } } }, "connectors" : [ ] }, { "id" : 118613, "reactomeId" : 10144363, "displayName" : "IL3:IL3RA:IL3RB:JAK2", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 1149, "y" : 88 }, "minX" : 1085, "maxX" : 1219, "minY" : 63, "maxY" : 107, "prop" : { "x" : 1085, "y" : 69, "width" : 128, "height" : 38 }, "textPosition" : { "x" : 1097, "y" : 72 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1213, "y" : 69 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1213, "y" : 69 } } }, "connectors" : [ ] }, { "id" : 118615, "reactomeId" : 10116968, "displayName" : "PTPN11", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 394, "y" : 1559 }, "minX" : 363, "maxX" : 431, "minY" : 1542, "maxY" : 1571, "prop" : { "x" : 363, "y" : 1548, "width" : 62, "height" : 23 }, "textPosition" : { "x" : 366, "y" : 1549 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 425, "y" : 1548 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 425, "y" : 1548 } } }, "connectors" : [ ] }, { "id" : 118614, "reactomeId" : 10142257, "displayName" : "High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p-(Y593,628)-Bc:p(427,349,350)-SHC1", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 1592, "y" : 658 }, "minX" : 1527, "maxX" : 1658, "minY" : 602, "maxY" : 715, "prop" : { "x" : 1527, "y" : 602, "width" : 131, "height" : 113 }, "textPosition" : { "x" : 1525, "y" : 606 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "connectors" : [ ] }, { "id" : 118620, "reactomeId" : 10224791, "displayName" : "RAF/MAP kinase cascade", "schemaClass" : "Pathway", "renderableClass" : "EncapsulatedNode", "position" : { "x" : 1420, "y" : 1499 }, "minX" : 1359, "maxX" : 1481, "minY" : 1470, "maxY" : 1529, "prop" : { "x" : 1359, "y" : 1470, "width" : 122, "height" : 59 }, "textPosition" : { "x" : 1361, "y" : 1478 }, "connectors" : [ ] }, { "id" : 118519, "reactomeId" : 10144375, "displayName" : "High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 95, "y" : 817 }, "minX" : 30, "maxX" : 1495, "minY" : 207, "maxY" : 906, "prop" : { "x" : 30, "y" : 776, "width" : 131, "height" : 83 }, "textPosition" : { "x" : 28, "y" : 779 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "connectors" : [ { "edgeId" : 118536, "type" : "INPUT", "segments" : [ { "from" : { "x" : 167, "y" : 788 }, "to" : { "x" : 1495, "y" : 207 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 118570, "type" : "INPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 118517, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 118523, "type" : "INPUT", "segments" : [ { "from" : { "x" : 148, "y" : 865 }, "to" : { "x" : 174, "y" : 878 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 118523, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 112, "y" : 865 }, "to" : { "x" : 130, "y" : 901 } }, { "from" : { "x" : 130, "y" : 901 }, "to" : { "x" : 157, "y" : 902 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 161, "y" : 902 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 161, "y" : 902 } } } ] }, { "id" : 118518, "reactomeId" : 10144450, "displayName" : "High affinity binding complexes of interleukin receptors using the Common beta chain", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 95, "y" : 659 }, "minX" : 30, "maxX" : 161, "minY" : 618, "maxY" : 729, "prop" : { "x" : 30, "y" : 618, "width" : 131, "height" : 83 }, "textPosition" : { "x" : 28, "y" : 614 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "connectors" : [ { "edgeId" : 118517, "type" : "INPUT", "segments" : [ ], "stoichiometry" : { "value" : 2, "shape" : { "a" : { "x" : 88, "y" : 717 }, "b" : { "x" : 100, "y" : 729 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 94, "y" : 723 } } } } ] }, { "id" : 118521, "reactomeId" : 10142245, "displayName" : "Il5", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 757, "y" : 18 }, "minX" : 744, "maxX" : 803, "minY" : 1, "maxY" : 30, "prop" : { "x" : 744, "y" : 7, "width" : 26, "height" : 23 }, "textPosition" : { "x" : 746, "y" : 8 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 770, "y" : 7 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 770, "y" : 7 } } }, "connectors" : [ { "edgeId" : 118520, "type" : "INPUT", "segments" : [ ], "stoichiometry" : { "value" : 2, "shape" : { "a" : { "x" : 791, "y" : 12 }, "b" : { "x" : 803, "y" : 24 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 797, "y" : 18 } } } } ] }, { "id" : 118522, "reactomeId" : 10142247, "displayName" : "IL5 homodimer", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 907, "y" : 18 }, "minX" : 857, "maxX" : 963, "minY" : 1, "maxY" : 29, "prop" : { "x" : 857, "y" : 7, "width" : 100, "height" : 22 }, "textPosition" : { "x" : 857, "y" : 8 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 957, "y" : 7 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 957, "y" : 7 } } }, "connectors" : [ { "edgeId" : 118520, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 118525, "reactomeId" : 29370, "displayName" : "ADP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 222, "y" : 955 }, "minX" : 174, "maxX" : 244, "minY" : 930, "maxY" : 971, "prop" : { "x" : 201, "y" : 940, "width" : 42, "height" : 31 }, "textPosition" : { "x" : 205, "y" : 945 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 238, "y" : 945 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 238, "y" : 945 } } }, "connectors" : [ { "edgeId" : 118523, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 198, "y" : 944 }, "to" : { "x" : 174, "y" : 930 } } ], "stoichiometry" : { "value" : 6, "shape" : { "a" : { "x" : 180, "y" : 931 }, "b" : { "x" : 192, "y" : 943 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 186, "y" : 937 } } }, "endShape" : { "a" : { "x" : 190, "y" : 944 }, "b" : { "x" : 198, "y" : 944 }, "c" : { "x" : 194, "y" : 937 }, "type" : "ARROW", "centre" : { "x" : 194, "y" : 937 } } } ] }, { "id" : 118524, "reactomeId" : 113592, "displayName" : "ATP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 224, "y" : 842 }, "minX" : 174, "maxX" : 246, "minY" : 826, "maxY" : 878, "prop" : { "x" : 203, "y" : 827, "width" : 42, "height" : 31 }, "textPosition" : { "x" : 208, "y" : 832 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 240, "y" : 832 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 240, "y" : 832 } } }, "connectors" : [ { "edgeId" : 118523, "type" : "INPUT", "segments" : [ { "from" : { "x" : 200, "y" : 857 }, "to" : { "x" : 174, "y" : 878 } } ], "stoichiometry" : { "value" : 6, "shape" : { "a" : { "x" : 181, "y" : 861 }, "b" : { "x" : 193, "y" : 873 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 187, "y" : 867 } } } } ] }, { "id" : 118526, "reactomeId" : 10144417, "displayName" : "High affinity binding complex dimers of cytokine receptors using Bc, activated JAK2", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 95, "y" : 989 }, "minX" : 4, "maxX" : 174, "minY" : 930, "maxY" : 1155, "prop" : { "x" : 30, "y" : 948, "width" : 131, "height" : 83 }, "textPosition" : { "x" : 28, "y" : 951 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "connectors" : [ { "edgeId" : 118534, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 57, "y" : 1037 }, "to" : { "x" : 6, "y" : 1087 } }, { "from" : { "x" : 6, "y" : 1087 }, "to" : { "x" : 4, "y" : 1155 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 55, "y" : 1045 }, "b" : { "x" : 57, "y" : 1037 }, "c" : { "x" : 49, "y" : 1039 }, "type" : "ARROW", "centre" : { "x" : 49, "y" : 1039 } } }, { "edgeId" : 118523, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 150, "y" : 942 }, "to" : { "x" : 174, "y" : 930 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 154, "y" : 935 }, "b" : { "x" : 150, "y" : 942 }, "c" : { "x" : 158, "y" : 942 }, "type" : "ARROW", "centre" : { "x" : 158, "y" : 942 } } }, { "edgeId" : 118527, "type" : "INPUT", "segments" : [ { "from" : { "x" : 154, "y" : 1037 }, "to" : { "x" : 168, "y" : 1040 } } ], "stoichiometry" : { "value" : 1 } } ] } ], "edges" : [ { "id" : 118593, "reactomeId" : 10144960, "displayName" : "CBL binds CRK", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 861, "y" : 1532 }, "minX" : 798, "maxX" : 929, "minY" : 1526, "maxY" : 1538, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 798, "y" : 1533 }, "to" : { "x" : 861, "y" : 1532 } }, { "from" : { "x" : 861, "y" : 1532 }, "to" : { "x" : 929, "y" : 1532 } } ], "endShape" : { "a" : { "x" : 922, "y" : 1536 }, "b" : { "x" : 929, "y" : 1532 }, "c" : { "x" : 922, "y" : 1528 }, "type" : "ARROW", "centre" : { "x" : 922, "y" : 1528 } }, "reactionShape" : { "c" : { "x" : 861, "y" : 1532 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 861, "y" : 1532 } }, "inputs" : [ { "id" : 118594, "points" : [ { "x" : 763, "y" : 1521 } ] }, { "id" : 118587, "points" : [ { "x" : 704, "y" : 1613 } ] } ], "outputs" : [ { "id" : 118595 } ] }, { "id" : 118530, "reactomeId" : 10144415, "displayName" : "Activation of STAT5a/b by JAK2", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 175, "y" : 1221 }, "minX" : 169, "maxX" : 181, "minY" : 1195, "maxY" : 1248, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 175, "y" : 1195 }, "to" : { "x" : 175, "y" : 1221 } }, { "from" : { "x" : 175, "y" : 1221 }, "to" : { "x" : 176, "y" : 1248 } } ], "reactionShape" : { "a" : { "x" : 169, "y" : 1215 }, "b" : { "x" : 181, "y" : 1227 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 175, "y" : 1221 } }, "inputs" : [ { "id" : 118529, "points" : [ { "x" : 143, "y" : 1170 } ] }, { "id" : 118531, "points" : [ { "x" : 202, "y" : 1177 } ], "stoichiometry" : 6 } ], "outputs" : [ { "id" : 118532, "points" : [ { "x" : 204, "y" : 1267 } ], "stoichiometry" : 6 }, { "id" : 118533, "points" : [ { "x" : 130, "y" : 1296 } ] } ], "catalysts" : [ { "id" : 118529, "points" : [ { "x" : 104, "y" : 1170 }, { "x" : 106, "y" : 1221 } ] } ] }, { "id" : 118596, "reactomeId" : 10144935, "displayName" : "CBL:CRKL binds RAPGEF1", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 1103, "y" : 1478 }, "minX" : 1068, "maxX" : 1136, "minY" : 1472, "maxY" : 1484, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 1068, "y" : 1479 }, "to" : { "x" : 1103, "y" : 1478 } }, { "from" : { "x" : 1103, "y" : 1478 }, "to" : { "x" : 1136, "y" : 1479 } } ], "endShape" : { "a" : { "x" : 1129, "y" : 1483 }, "b" : { "x" : 1136, "y" : 1479 }, "c" : { "x" : 1129, "y" : 1475 }, "type" : "ARROW", "centre" : { "x" : 1129, "y" : 1475 } }, "reactionShape" : { "c" : { "x" : 1103, "y" : 1478 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 1103, "y" : 1478 } }, "inputs" : [ { "id" : 118595, "points" : [ { "x" : 1021, "y" : 1510 } ] }, { "id" : 118597, "points" : [ { "x" : 1039, "y" : 1468 } ] } ], "outputs" : [ { "id" : 118598 } ] }, { "id" : 118534, "reactomeId" : 10145829, "displayName" : "p-STAT5 dissociates from the receptor complex", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 6, "y" : 1235 }, "minX" : 0, "maxX" : 60, "minY" : 1155, "maxY" : 1296, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 60, "y" : 1296 }, "to" : { "x" : 6, "y" : 1235 } }, { "from" : { "x" : 6, "y" : 1235 }, "to" : { "x" : 4, "y" : 1155 } } ], "reactionShape" : { "a" : { "x" : 0, "y" : 1229 }, "b" : { "x" : 12, "y" : 1241 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 6, "y" : 1235 } }, "inputs" : [ { "id" : 118533 } ], "outputs" : [ { "id" : 118535, "points" : [ { "x" : 201, "y" : 1319 } ], "stoichiometry" : 3 }, { "id" : 118526, "points" : [ { "x" : 57, "y" : 1037 }, { "x" : 6, "y" : 1087 } ] } ] }, { "id" : 118536, "reactomeId" : 10144392, "displayName" : "Tyrosine kinases phosphorylate the receptor", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 1496, "y" : 231 }, "minX" : 1490, "maxX" : 1502, "minY" : 207, "maxY" : 260, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 1495, "y" : 207 }, "to" : { "x" : 1496, "y" : 231 } }, { "from" : { "x" : 1496, "y" : 231 }, "to" : { "x" : 1495, "y" : 260 } } ], "reactionShape" : { "a" : { "x" : 1490, "y" : 225 }, "b" : { "x" : 1502, "y" : 237 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1496, "y" : 231 } }, "inputs" : [ { "id" : 118519, "points" : [ { "x" : 167, "y" : 788 } ] }, { "id" : 118537, "points" : [ { "x" : 1464, "y" : 187 } ], "stoichiometry" : 12 } ], "outputs" : [ { "id" : 118538, "points" : [ { "x" : 1521, "y" : 271 } ] }, { "id" : 118539, "points" : [ { "x" : 1464, "y" : 299 } ], "stoichiometry" : 12 } ], "catalysts" : [ { "id" : 118540, "points" : [ { "x" : 1562, "y" : 201 }, { "x" : 1533, "y" : 230 } ] } ] }, { "id" : 118541, "reactomeId" : 10144448, "displayName" : "Recruitment of SHC1 is mediated by Y593 of the common beta chain", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 1568, "y" : 401 }, "minX" : 1562, "maxX" : 1578, "minY" : 367, "maxY" : 435, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 1569, "y" : 367 }, "to" : { "x" : 1568, "y" : 401 } }, { "from" : { "x" : 1568, "y" : 401 }, "to" : { "x" : 1578, "y" : 435 } } ], "endShape" : { "a" : { "x" : 1572, "y" : 429 }, "b" : { "x" : 1578, "y" : 435 }, "c" : { "x" : 1580, "y" : 427 }, "type" : "ARROW", "centre" : { "x" : 1580, "y" : 427 } }, "reactionShape" : { "a" : { "x" : 1562, "y" : 395 }, "b" : { "x" : 1574, "y" : 407 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1568, "y" : 401 } }, "inputs" : [ { "id" : 118542, "points" : [ { "x" : 1536, "y" : 378 } ], "stoichiometry" : 3 }, { "id" : 118538, "points" : [ { "x" : 1584, "y" : 348 } ] } ], "outputs" : [ { "id" : 118543 } ] }, { "id" : 118544, "reactomeId" : 10142285, "displayName" : "Phosphorylated SHC1 recruits GRB2:GAB2", "schemaClass" : "BlackBoxEvent", "renderableClass" : "Reaction", "position" : { "x" : 1592, "y" : 839 }, "minX" : 1586, "maxX" : 1608, "minY" : 822, "maxY" : 856, "reactionType" : "omitted", "segments" : [ { "from" : { "x" : 1586, "y" : 822 }, "to" : { "x" : 1592, "y" : 839 } }, { "from" : { "x" : 1592, "y" : 839 }, "to" : { "x" : 1608, "y" : 856 } } ], "endShape" : { "a" : { "x" : 1600, "y" : 854 }, "b" : { "x" : 1608, "y" : 856 }, "c" : { "x" : 1606, "y" : 848 }, "type" : "ARROW", "centre" : { "x" : 1606, "y" : 848 } }, "reactionShape" : { "a" : { "x" : 1586, "y" : 833 }, "b" : { "x" : 1598, "y" : 845 }, "s" : "\\\\", "type" : "BOX", "empty" : true, "centre" : { "x" : 1592, "y" : 839 } }, "inputs" : [ { "id" : 118545, "points" : [ { "x" : 1469, "y" : 817 } ], "stoichiometry" : 4 }, { "id" : 118546, "points" : [ { "x" : 1593, "y" : 803 } ] } ], "outputs" : [ { "id" : 118547 } ] }, { "id" : 118548, "reactomeId" : 10144841, "displayName" : "SHC1 mediates cytokine-induced phosphorylation of GAB2", "schemaClass" : "BlackBoxEvent", "renderableClass" : "Reaction", "position" : { "x" : 1594, "y" : 978 }, "minX" : 1588, "maxX" : 1600, "minY" : 959, "maxY" : 998, "reactionType" : "omitted", "segments" : [ { "from" : { "x" : 1594, "y" : 959 }, "to" : { "x" : 1594, "y" : 978 } }, { "from" : { "x" : 1594, "y" : 978 }, "to" : { "x" : 1594, "y" : 998 } } ], "reactionShape" : { "a" : { "x" : 1588, "y" : 972 }, "b" : { "x" : 1600, "y" : 984 }, "s" : "\\\\", "type" : "BOX", "empty" : true, "centre" : { "x" : 1594, "y" : 978 } }, "inputs" : [ { "id" : 118547, "points" : [ { "x" : 1612, "y" : 932 } ] }, { "id" : 118549, "points" : [ { "x" : 1552, "y" : 959 } ], "stoichiometry" : 4 } ], "outputs" : [ { "id" : 118550, "points" : [ { "x" : 1603, "y" : 1014 } ] }, { "id" : 118551, "points" : [ { "x" : 1553, "y" : 998 } ], "stoichiometry" : 4 } ] }, { "id" : 118552, "reactomeId" : 10143239, "displayName" : "Gab2 binds the p85 subunit of Class 1A PI3 kinases", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 1590, "y" : 1148 }, "minX" : 1584, "maxX" : 1596, "minY" : 1110, "maxY" : 1178, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 1591, "y" : 1110 }, "to" : { "x" : 1590, "y" : 1148 } }, { "from" : { "x" : 1590, "y" : 1148 }, "to" : { "x" : 1591, "y" : 1178 } } ], "endShape" : { "a" : { "x" : 1587, "y" : 1171 }, "b" : { "x" : 1591, "y" : 1178 }, "c" : { "x" : 1595, "y" : 1171 }, "type" : "ARROW", "centre" : { "x" : 1595, "y" : 1171 } }, "reactionShape" : { "a" : { "x" : 1584, "y" : 1142 }, "b" : { "x" : 1596, "y" : 1154 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1590, "y" : 1148 } }, "inputs" : [ { "id" : 118553, "points" : [ { "x" : 1113, "y" : 953 } ], "stoichiometry" : 4 }, { "id" : 118550, "points" : [ { "x" : 1602, "y" : 1090 } ] } ], "outputs" : [ { "id" : 118554 } ] }, { "id" : 118555, "reactomeId" : 10142289, "displayName" : "Phosphorylated SHC recruits GRB2:SOS1", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 1387, "y" : 1318 }, "minX" : 1381, "maxX" : 1528, "minY" : 1197, "maxY" : 1358, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 1388, "y" : 1197 }, "to" : { "x" : 1387, "y" : 1318 } }, { "from" : { "x" : 1387, "y" : 1318 }, "to" : { "x" : 1528, "y" : 1358 } } ], "endShape" : { "a" : { "x" : 1520, "y" : 1360 }, "b" : { "x" : 1528, "y" : 1358 }, "c" : { "x" : 1522, "y" : 1352 }, "type" : "ARROW", "centre" : { "x" : 1522, "y" : 1352 } }, "reactionShape" : { "c" : { "x" : 1387, "y" : 1318 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 1387, "y" : 1318 } }, "inputs" : [ { "id" : 118556, "points" : [ { "x" : 1338, "y" : 1164 } ], "stoichiometry" : 4 }, { "id" : 118546, "points" : [ { "x" : 1587, "y" : 803 } ] } ], "outputs" : [ { "id" : 118557 } ] }, { "id" : 118558, "reactomeId" : 10144970, "displayName" : "Phosphorylated SHC1 recruits SHIP", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 1319, "y" : 1684 }, "minX" : 1233, "maxX" : 1325, "minY" : 1083, "maxY" : 1849, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 1233, "y" : 1083 }, "to" : { "x" : 1319, "y" : 1684 } }, { "from" : { "x" : 1319, "y" : 1684 }, "to" : { "x" : 1321, "y" : 1849 } } ], "endShape" : { "a" : { "x" : 1317, "y" : 1842 }, "b" : { "x" : 1321, "y" : 1849 }, "c" : { "x" : 1325, "y" : 1842 }, "type" : "ARROW", "centre" : { "x" : 1325, "y" : 1842 } }, "reactionShape" : { "c" : { "x" : 1319, "y" : 1684 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 1319, "y" : 1684 } }, "inputs" : [ { "id" : 118546, "points" : [ { "x" : 1565, "y" : 803 } ] }, { "id" : 118559, "points" : [ { "x" : 1181, "y" : 1036 } ], "stoichiometry" : 4 } ], "outputs" : [ { "id" : 118560 } ] }, { "id" : 118561, "reactomeId" : 10144976, "displayName" : "The SHC1:SHIP1 complex is stabilized by GRB2", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 519, "y" : 1878 }, "minX" : 495, "maxX" : 566, "minY" : 1872, "maxY" : 1886, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 495, "y" : 1878 }, "to" : { "x" : 519, "y" : 1878 } }, { "from" : { "x" : 519, "y" : 1878 }, "to" : { "x" : 566, "y" : 1886 } } ], "endShape" : { "a" : { "x" : 558, "y" : 1889 }, "b" : { "x" : 566, "y" : 1886 }, "c" : { "x" : 560, "y" : 1881 }, "type" : "ARROW", "centre" : { "x" : 560, "y" : 1881 } }, "reactionShape" : { "c" : { "x" : 519, "y" : 1878 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 519, "y" : 1878 } }, "inputs" : [ { "id" : 118562, "points" : [ { "x" : 449, "y" : 1815 } ], "stoichiometry" : 4 }, { "id" : 118563, "points" : [ { "x" : 468, "y" : 1883 } ] } ], "outputs" : [ { "id" : 118564 } ] }, { "id" : 118565, "reactomeId" : 10144839, "displayName" : "SHP1 and SHP2 bind the common beta chain", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 206, "y" : 1445 }, "minX" : 149, "maxX" : 355, "minY" : 1439, "maxY" : 1464, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 355, "y" : 1443 }, "to" : { "x" : 206, "y" : 1445 } }, { "from" : { "x" : 206, "y" : 1445 }, "to" : { "x" : 149, "y" : 1464 } } ], "endShape" : { "a" : { "x" : 154, "y" : 1458 }, "b" : { "x" : 149, "y" : 1464 }, "c" : { "x" : 157, "y" : 1466 }, "type" : "ARROW", "centre" : { "x" : 157, "y" : 1466 } }, "reactionShape" : { "c" : { "x" : 206, "y" : 1445 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 206, "y" : 1445 } }, "inputs" : [ { "id" : 118566, "points" : [ { "x" : 386, "y" : 1476 } ] }, { "id" : 118538, "points" : [ { "x" : 1521, "y" : 334 }, { "x" : 541, "y" : 712 }, { "x" : 545, "y" : 1335 } ] } ], "outputs" : [ { "id" : 118567 } ] }, { "id" : 118568, "reactomeId" : 10145496, "displayName" : "SHP1 and SHP2 dephosphorylate Y628 of IL3RB", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 79, "y" : 1583 }, "minX" : 73, "maxX" : 85, "minY" : 1537, "maxY" : 1613, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 79, "y" : 1537 }, "to" : { "x" : 79, "y" : 1583 } }, { "from" : { "x" : 79, "y" : 1583 }, "to" : { "x" : 79, "y" : 1613 } } ], "endShape" : { "a" : { "x" : 75, "y" : 1606 }, "b" : { "x" : 79, "y" : 1613 }, "c" : { "x" : 83, "y" : 1606 }, "type" : "ARROW", "centre" : { "x" : 83, "y" : 1606 } }, "reactionShape" : { "a" : { "x" : 73, "y" : 1577 }, "b" : { "x" : 85, "y" : 1589 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 79, "y" : 1583 } }, "inputs" : [ { "id" : 118567 } ], "outputs" : [ { "id" : 118569 } ], "catalysts" : [ { "id" : 118567, "points" : [ { "x" : 54, "y" : 1537 }, { "x" : 29, "y" : 1582 } ] } ] }, { "id" : 118570, "reactomeId" : 10144981, "displayName" : "IL3RB is phosphorylated on Ser-585", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 205, "y" : 644 }, "minX" : 135, "maxX" : 211, "minY" : 578, "maxY" : 770, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 135, "y" : 770 }, "to" : { "x" : 202, "y" : 706 } }, { "from" : { "x" : 202, "y" : 706 }, "to" : { "x" : 205, "y" : 644 } }, { "from" : { "x" : 205, "y" : 644 }, "to" : { "x" : 135, "y" : 578 } } ], "endShape" : { "a" : { "x" : 143, "y" : 580 }, "b" : { "x" : 135, "y" : 578 }, "c" : { "x" : 137, "y" : 586 }, "type" : "ARROW", "centre" : { "x" : 137, "y" : 586 } }, "reactionShape" : { "a" : { "x" : 199, "y" : 638 }, "b" : { "x" : 211, "y" : 650 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 205, "y" : 644 } }, "inputs" : [ { "id" : 118519 } ], "outputs" : [ { "id" : 118571 } ], "catalysts" : [ { "id" : 118572, "points" : [ { "x" : 252, "y" : 642 } ] } ] }, { "id" : 118573, "reactomeId" : 10144958, "displayName" : "p-S585-IL3RB binds 14-3-3 proteins", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 201, "y" : 441 }, "minX" : 164, "maxX" : 207, "minY" : 434, "maxY" : 482, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 201, "y" : 482 }, "to" : { "x" : 201, "y" : 441 } }, { "from" : { "x" : 201, "y" : 441 }, "to" : { "x" : 164, "y" : 434 } } ], "endShape" : { "a" : { "x" : 172, "y" : 431 }, "b" : { "x" : 164, "y" : 434 }, "c" : { "x" : 170, "y" : 439 }, "type" : "ARROW", "centre" : { "x" : 170, "y" : 439 } }, "reactionShape" : { "c" : { "x" : 201, "y" : 441 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 201, "y" : 441 } }, "inputs" : [ { "id" : 118574, "points" : [ { "x" : 228, "y" : 492 } ] }, { "id" : 118571, "points" : [ { "x" : 167, "y" : 500 } ] } ], "outputs" : [ { "id" : 118575 } ] }, { "id" : 118576, "reactomeId" : 10144424, "displayName" : "IL3 stimulation induces Vav binding to Tec kinase", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 771, "y" : 1822 }, "minX" : 765, "maxX" : 777, "minY" : 1808, "maxY" : 1856, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 771, "y" : 1808 }, "to" : { "x" : 771, "y" : 1822 } }, { "from" : { "x" : 771, "y" : 1822 }, "to" : { "x" : 772, "y" : 1856 } } ], "endShape" : { "a" : { "x" : 768, "y" : 1849 }, "b" : { "x" : 772, "y" : 1856 }, "c" : { "x" : 776, "y" : 1849 }, "type" : "ARROW", "centre" : { "x" : 776, "y" : 1849 } }, "reactionShape" : { "c" : { "x" : 771, "y" : 1822 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 771, "y" : 1822 } }, "inputs" : [ { "id" : 118577, "points" : [ { "x" : 789, "y" : 1783 } ] }, { "id" : 118578, "points" : [ { "x" : 751, "y" : 1783 } ] } ], "outputs" : [ { "id" : 118579 } ] }, { "id" : 118517, "reactomeId" : 10144452, "displayName" : "The receptor is activated", "schemaClass" : "BlackBoxEvent", "renderableClass" : "Reaction", "position" : { "x" : 94, "y" : 740 }, "minX" : 88, "maxX" : 100, "minY" : 707, "maxY" : 770, "reactionType" : "omitted", "segments" : [ { "from" : { "x" : 94, "y" : 707 }, "to" : { "x" : 94, "y" : 740 } }, { "from" : { "x" : 94, "y" : 740 }, "to" : { "x" : 94, "y" : 770 } } ], "endShape" : { "a" : { "x" : 90, "y" : 763 }, "b" : { "x" : 94, "y" : 770 }, "c" : { "x" : 98, "y" : 763 }, "type" : "ARROW", "centre" : { "x" : 98, "y" : 763 } }, "reactionShape" : { "a" : { "x" : 88, "y" : 734 }, "b" : { "x" : 100, "y" : 746 }, "s" : "\\\\", "type" : "BOX", "empty" : true, "centre" : { "x" : 94, "y" : 740 } }, "inputs" : [ { "id" : 118518, "stoichiometry" : 2 } ], "outputs" : [ { "id" : 118519 } ] }, { "id" : 118580, "reactomeId" : 10145500, "displayName" : "14-3-3 zeta binding allows recruitment of PI3K", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 205, "y" : 313 }, "minX" : 182, "maxX" : 211, "minY" : 307, "maxY" : 362, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 206, "y" : 362 }, "to" : { "x" : 205, "y" : 313 } }, { "from" : { "x" : 205, "y" : 313 }, "to" : { "x" : 182, "y" : 309 } } ], "endShape" : { "a" : { "x" : 190, "y" : 306 }, "b" : { "x" : 182, "y" : 309 }, "c" : { "x" : 188, "y" : 314 }, "type" : "ARROW", "centre" : { "x" : 188, "y" : 314 } }, "reactionShape" : { "c" : { "x" : 205, "y" : 313 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 205, "y" : 313 } }, "inputs" : [ { "id" : 118553, "points" : [ { "x" : 1033, "y" : 905 } ] }, { "id" : 118575, "points" : [ { "x" : 164, "y" : 387 } ] } ], "outputs" : [ { "id" : 118581 } ] }, { "id" : 118582, "reactomeId" : 10144436, "displayName" : "CBL, GRB2, FYN and PI3K p85 subunit are constitutively associated", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 650, "y" : 1445 }, "minX" : 565, "maxX" : 702, "minY" : 1324, "maxY" : 1625, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 565, "y" : 1625 }, "to" : { "x" : 650, "y" : 1445 } }, { "from" : { "x" : 650, "y" : 1445 }, "to" : { "x" : 702, "y" : 1324 } } ], "endShape" : { "a" : { "x" : 703, "y" : 1332 }, "b" : { "x" : 702, "y" : 1324 }, "c" : { "x" : 696, "y" : 1329 }, "type" : "ARROW", "centre" : { "x" : 696, "y" : 1329 } }, "reactionShape" : { "c" : { "x" : 650, "y" : 1445 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 650, "y" : 1445 } }, "inputs" : [ { "id" : 118562, "points" : [ { "x" : 449, "y" : 1787 } ] }, { "id" : 118583, "points" : [ { "x" : 519, "y" : 1628 } ] }, { "id" : 118553, "points" : [ { "x" : 1048, "y" : 953 } ] }, { "id" : 118584, "points" : [ { "x" : 561, "y" : 1701 } ] } ], "outputs" : [ { "id" : 118585 } ] }, { "id" : 118520, "reactomeId" : 10144978, "displayName" : "Interleukin-5 is a homodimer", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 821, "y" : 18 }, "minX" : 773, "maxX" : 854, "minY" : 12, "maxY" : 24, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 773, "y" : 18 }, "to" : { "x" : 821, "y" : 18 } }, { "from" : { "x" : 821, "y" : 18 }, "to" : { "x" : 854, "y" : 18 } } ], "endShape" : { "a" : { "x" : 847, "y" : 22 }, "b" : { "x" : 854, "y" : 18 }, "c" : { "x" : 847, "y" : 14 }, "type" : "ARROW", "centre" : { "x" : 847, "y" : 14 } }, "reactionShape" : { "c" : { "x" : 821, "y" : 18 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 821, "y" : 18 } }, "inputs" : [ { "id" : 118521, "stoichiometry" : 2 } ], "outputs" : [ { "id" : 118522 } ] }, { "id" : 118523, "reactomeId" : 10144420, "displayName" : "JAK2 is phosphorylated, activated", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 173, "y" : 902 }, "minX" : 167, "maxX" : 179, "minY" : 878, "maxY" : 930, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 174, "y" : 878 }, "to" : { "x" : 173, "y" : 902 } }, { "from" : { "x" : 173, "y" : 902 }, "to" : { "x" : 174, "y" : 930 } } ], "reactionShape" : { "a" : { "x" : 167, "y" : 896 }, "b" : { "x" : 179, "y" : 908 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 173, "y" : 902 } }, "inputs" : [ { "id" : 118524, "points" : [ { "x" : 200, "y" : 857 } ], "stoichiometry" : 6 }, { "id" : 118519, "points" : [ { "x" : 148, "y" : 865 } ] } ], "outputs" : [ { "id" : 118525, "points" : [ { "x" : 198, "y" : 944 } ], "stoichiometry" : 6 }, { "id" : 118526, "points" : [ { "x" : 150, "y" : 942 } ] } ], "catalysts" : [ { "id" : 118519, "points" : [ { "x" : 112, "y" : 865 }, { "x" : 130, "y" : 901 } ] } ] }, { "id" : 118586, "reactomeId" : 10144929, "displayName" : "CBL binds VAV", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 865, "y" : 1724 }, "minX" : 830, "maxX" : 900, "minY" : 1718, "maxY" : 1730, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 830, "y" : 1724 }, "to" : { "x" : 865, "y" : 1724 } }, { "from" : { "x" : 865, "y" : 1724 }, "to" : { "x" : 900, "y" : 1724 } } ], "endShape" : { "a" : { "x" : 893, "y" : 1728 }, "b" : { "x" : 900, "y" : 1724 }, "c" : { "x" : 893, "y" : 1720 }, "type" : "ARROW", "centre" : { "x" : 893, "y" : 1720 } }, "reactionShape" : { "c" : { "x" : 865, "y" : 1724 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 865, "y" : 1724 } }, "inputs" : [ { "id" : 118587, "points" : [ { "x" : 722, "y" : 1669 } ] }, { "id" : 118577, "points" : [ { "x" : 805, "y" : 1754 } ] } ], "outputs" : [ { "id" : 118588 } ] }, { "id" : 118589, "reactomeId" : 10144917, "displayName" : "CBL ubiquitinates PI3K", "schemaClass" : "BlackBoxEvent", "renderableClass" : "Reaction", "position" : { "x" : 682, "y" : 998 }, "minX" : 676, "maxX" : 688, "minY" : 951, "maxY" : 1036, "reactionType" : "omitted", "segments" : [ { "from" : { "x" : 683, "y" : 1036 }, "to" : { "x" : 682, "y" : 998 } }, { "from" : { "x" : 682, "y" : 998 }, "to" : { "x" : 681, "y" : 951 } } ], "endShape" : { "a" : { "x" : 685, "y" : 958 }, "b" : { "x" : 681, "y" : 951 }, "c" : { "x" : 677, "y" : 958 }, "type" : "ARROW", "centre" : { "x" : 677, "y" : 958 } }, "reactionShape" : { "a" : { "x" : 676, "y" : 992 }, "b" : { "x" : 688, "y" : 1004 }, "s" : "\\\\", "type" : "BOX", "empty" : true, "centre" : { "x" : 682, "y" : 998 } }, "inputs" : [ { "id" : 118590, "points" : [ { "x" : 717, "y" : 1053 } ] }, { "id" : 118591, "points" : [ { "x" : 641, "y" : 1056 } ] } ], "outputs" : [ { "id" : 118592 } ] }, { "id" : 118527, "reactomeId" : 10144446, "displayName" : "STAT5 is recruited by JAK2", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 169, "y" : 1063 }, "minX" : 149, "maxX" : 175, "minY" : 1040, "maxY" : 1075, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 168, "y" : 1040 }, "to" : { "x" : 169, "y" : 1063 } }, { "from" : { "x" : 169, "y" : 1063 }, "to" : { "x" : 149, "y" : 1075 } } ], "endShape" : { "a" : { "x" : 153, "y" : 1068 }, "b" : { "x" : 149, "y" : 1075 }, "c" : { "x" : 157, "y" : 1075 }, "type" : "ARROW", "centre" : { "x" : 157, "y" : 1075 } }, "reactionShape" : { "a" : { "x" : 163, "y" : 1057 }, "b" : { "x" : 175, "y" : 1069 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 169, "y" : 1063 } }, "inputs" : [ { "id" : 118526, "points" : [ { "x" : 154, "y" : 1037 } ] }, { "id" : 118528, "points" : [ { "x" : 204, "y" : 1027 } ], "stoichiometry" : 3 } ], "outputs" : [ { "id" : 118529 } ] } ], "compartments" : [ { "id" : 118599, "reactomeId" : 70101, "displayName" : "cytosol", "schemaClass" : "Compartment", "renderableClass" : "Compartment", "position" : { "x" : 830, "y" : 995 }, "minX" : 62, "maxX" : 1598, "minY" : 85, "maxY" : 1906, "prop" : { "x" : 62, "y" : 85, "width" : 1536, "height" : 1821 }, "textPosition" : { "x" : 1474, "y" : 1848 }, "insets" : { "x" : 72, "y" : 95, "width" : 1516, "height" : 1801 }, "bgColor" : { "r" : 250, "g" : 240, "b" : 240 }, "componentIds" : [ 118606, 118517, 118518, 118519, 118609, 118613, 118523, 118525, 118526, 118527, 118528, 118529, 118530, 118531, 118532, 118533, 118535, 118539, 118542, 118553, 118555, 118556, 118558, 118559, 118565, 118566, 118567, 118568, 118569, 118615, 118570, 118571, 118573, 118574, 118575, 118577, 118578, 118579, 118576, 118580, 118581, 118561, 118562, 118564, 118560, 118536, 118538, 118540, 118543, 118614, 118546, 118547, 118550, 118554, 118557, 118537, 118563, 118545, 118549, 118551, 118616, 118524, 118541, 118544, 118548, 118552, 118583, 118584, 118585, 118582, 118590, 118586, 118587, 118588, 118589, 118591, 118592, 118593, 118595, 118596, 118597, 118598, 118621, 118622, 118624, 118625, 118626, 118627, 118572, 118620, 118630, 118594, 118628, 118629 ] }, { "id" : 118616, "reactomeId" : 7660, "displayName" : "nucleoplasm", "schemaClass" : "Compartment", "renderableClass" : "Compartment", "position" : { "x" : 391, "y" : 1139 }, "minX" : 248, "maxX" : 535, "minY" : 1029, "maxY" : 1250, "prop" : { "x" : 248, "y" : 1029, "width" : 287, "height" : 221 }, "textPosition" : { "x" : 254, "y" : 1207 }, "insets" : { "x" : 258, "y" : 1039, "width" : 267, "height" : 201 }, "bgColor" : { "r" : 250, "g" : 240, "b" : 240 } } ], "notes" : [ ], "links" : [ { "id" : 118625, "renderableClass" : "EntitySetAndMemberLink", "position" : { "x" : 640, "y" : 366 }, "minX" : 167, "maxX" : 1114, "minY" : 110, "maxY" : 623, "segments" : [ { "from" : { "x" : 1114, "y" : 110 }, "to" : { "x" : 167, "y" : 623 } } ], "reactionShape" : { "a" : { "x" : 634, "y" : 360 }, "b" : { "x" : 646, "y" : 372 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 640, "y" : 366 } }, "inputs" : [ { "id" : 118613 } ], "outputs" : [ { "id" : 118518 } ] }, { "id" : 118624, "renderableClass" : "EntitySetAndMemberLink", "position" : { "x" : 1539, "y" : 120 }, "minX" : 1529, "maxX" : 1549, "minY" : 114, "maxY" : 126, "segments" : [ { "from" : { "x" : 1529, "y" : 115 }, "to" : { "x" : 1549, "y" : 125 } } ], "reactionShape" : { "a" : { "x" : 1533, "y" : 114 }, "b" : { "x" : 1545, "y" : 126 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1539, "y" : 120 } }, "inputs" : [ { "id" : 118609 } ], "outputs" : [ { "id" : 118540 } ] }, { "id" : 118627, "renderableClass" : "EntitySetAndMemberLink", "position" : { "x" : 800, "y" : 368 }, "minX" : 167, "maxX" : 1434, "minY" : 106, "maxY" : 631, "segments" : [ { "from" : { "x" : 1434, "y" : 106 }, "to" : { "x" : 167, "y" : 631 } } ], "reactionShape" : { "a" : { "x" : 794, "y" : 362 }, "b" : { "x" : 806, "y" : 374 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 800, "y" : 368 } }, "inputs" : [ { "id" : 118609 } ], "outputs" : [ { "id" : 118518 } ] }, { "id" : 118626, "renderableClass" : "EntitySetAndMemberLink", "position" : { "x" : 708, "y" : 372 }, "minX" : 167, "maxX" : 1250, "minY" : 116, "maxY" : 628, "segments" : [ { "from" : { "x" : 1250, "y" : 116 }, "to" : { "x" : 167, "y" : 628 } } ], "reactionShape" : { "a" : { "x" : 702, "y" : 366 }, "b" : { "x" : 714, "y" : 378 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 708, "y" : 372 } }, "inputs" : [ { "id" : 118606 } ], "outputs" : [ { "id" : 118518 } ] }, { "id" : 118629, "renderableClass" : "EntitySetAndEntitySetLink", "position" : { "x" : 842, "y" : 411 }, "minX" : 167, "maxX" : 1517, "minY" : 185, "maxY" : 637, "segments" : [ { "from" : { "x" : 1517, "y" : 185 }, "to" : { "x" : 167, "y" : 637 } } ], "reactionShape" : { "a" : { "x" : 836, "y" : 405 }, "b" : { "x" : 848, "y" : 417 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 842, "y" : 411 } }, "inputs" : [ { "id" : 118540 } ], "outputs" : [ { "id" : 118518 } ] }, { "id" : 118628, "renderableClass" : "EntitySetAndEntitySetLink", "position" : { "x" : 849, "y" : 577 }, "minX" : 167, "maxX" : 1531, "minY" : 201, "maxY" : 953, "segments" : [ { "from" : { "x" : 1531, "y" : 201 }, "to" : { "x" : 167, "y" : 953 } } ], "reactionShape" : { "a" : { "x" : 843, "y" : 571 }, "b" : { "x" : 855, "y" : 583 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 849, "y" : 577 } }, "inputs" : [ { "id" : 118540 } ], "outputs" : [ { "id" : 118526 } ] }, { "id" : 118631, "renderableClass" : "EntitySetAndMemberLink", "position" : { "x" : 1399, "y" : 6 }, "minX" : 1164, "maxX" : 1588, "minY" : 0, "maxY" : 125, "segments" : [ { "from" : { "x" : 1164, "y" : 66 }, "to" : { "x" : 1214, "y" : 7 } }, { "from" : { "x" : 1214, "y" : 7 }, "to" : { "x" : 1585, "y" : 5 } }, { "from" : { "x" : 1585, "y" : 5 }, "to" : { "x" : 1588, "y" : 125 } } ], "reactionShape" : { "a" : { "x" : 1393, "y" : 0 }, "b" : { "x" : 1405, "y" : 12 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1399, "y" : 6 } }, "inputs" : [ { "id" : 118613 } ], "outputs" : [ { "id" : 118540 } ] }, { "id" : 118630, "renderableClass" : "Interaction", "position" : { "x" : 1501, "y" : 1440 }, "minX" : 1461, "maxX" : 1541, "minY" : 1414, "maxY" : 1467, "interactionType" : "Activate", "segments" : [ { "from" : { "x" : 1541, "y" : 1414 }, "to" : { "x" : 1461, "y" : 1467 } } ], "endShape" : { "a" : { "x" : 1465, "y" : 1460 }, "b" : { "x" : 1461, "y" : 1467 }, "c" : { "x" : 1469, "y" : 1467 }, "type" : "ARROW", "empty" : true, "centre" : { "x" : 1469, "y" : 1467 } }, "reactionShape" : { "a" : { "x" : 1495, "y" : 1434 }, "b" : { "x" : 1507, "y" : 1446 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1501, "y" : 1440 } }, "inputs" : [ { "id" : 118557 } ], "outputs" : [ { "id" : 118620 } ] }, { "id" : 118621, "renderableClass" : "EntitySetAndMemberLink", "position" : { "x" : 395, "y" : 1531 }, "minX" : 389, "maxX" : 401, "minY" : 1517, "maxY" : 1545, "segments" : [ { "from" : { "x" : 394, "y" : 1545 }, "to" : { "x" : 396, "y" : 1517 } } ], "reactionShape" : { "a" : { "x" : 389, "y" : 1525 }, "b" : { "x" : 401, "y" : 1537 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 395, "y" : 1531 } }, "inputs" : [ { "id" : 118615 } ], "outputs" : [ { "id" : 118566 } ] }, { "id" : 118623, "renderableClass" : "EntitySetAndMemberLink", "position" : { "x" : 1553, "y" : 17 }, "minX" : 1371, "maxX" : 1581, "minY" : 11, "maxY" : 125, "segments" : [ { "from" : { "x" : 1371, "y" : 71 }, "to" : { "x" : 1553, "y" : 17 } }, { "from" : { "x" : 1553, "y" : 17 }, "to" : { "x" : 1581, "y" : 125 } } ], "reactionShape" : { "a" : { "x" : 1547, "y" : 11 }, "b" : { "x" : 1559, "y" : 23 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1553, "y" : 17 } }, "inputs" : [ { "id" : 118606 } ], "outputs" : [ { "id" : 118540 } ] }, { "id" : 118622, "renderableClass" : "EntitySetAndMemberLink", "position" : { "x" : 1596, "y" : 724 }, "minX" : 1590, "maxX" : 1602, "minY" : 718, "maxY" : 730, "segments" : [ { "from" : { "x" : 1596, "y" : 721 }, "to" : { "x" : 1597, "y" : 727 } } ], "reactionShape" : { "a" : { "x" : 1590, "y" : 718 }, "b" : { "x" : 1602, "y" : 730 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1596, "y" : 724 } }, "inputs" : [ { "id" : 118614 } ], "outputs" : [ { "id" : 118546 } ] } ], "shadows" : [ { "id" : 118633, "reactomeId" : 10224001, "displayName" : "Regulation of signaling by CBL", "schemaClass" : "Pathway", "renderableClass" : "Shadow", "position" : { "x" : 837, "y" : 1338 }, "minX" : 399, "maxX" : 1275, "minY" : 855, "maxY" : 1822, "prop" : { "x" : 399, "y" : 855, "width" : 876, "height" : 967 }, "points" : [ { "x" : 399, "y" : 855 }, { "x" : 1275, "y" : 855 }, { "x" : 1275, "y" : 1822 }, { "x" : 399, "y" : 1822 } ], "colour" : "#dc3912" }, { "id" : 118632, "reactomeId" : 10223939, "displayName" : "Interleukin receptor SHC signaling", "schemaClass" : "Pathway", "renderableClass" : "Shadow", "position" : { "x" : 1023, "y" : 1332 }, "minX" : 329, "maxX" : 1718, "minY" : 723, "maxY" : 1941, "prop" : { "x" : 1275, "y" : 855, "width" : 443, "height" : 967 }, "points" : [ { "x" : 329, "y" : 723 }, { "x" : 1718, "y" : 723 }, { "x" : 1718, "y" : 1941 }, { "x" : 329, "y" : 1941 } ], "colour" : "#4684ee" } ], "minX" : 0, "maxX" : 1708, "minY" : 0, "maxY" : 1931, "disease" : false }