{
  "dbId" : 10222241,
  "stableId" : "R-RNO-5625740",
  "displayName" : "RHO GTPases activate PKNs",
  "nodes" : [ {
    "id" : 86923,
    "reactomeId" : 10179109,
    "displayName" : "PKN1-3",
    "schemaClass" : "DefinedSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 231,
      "y" : 146
    },
    "minX" : 196,
    "maxX" : 267,
    "minY" : 91,
    "maxY" : 161,
    "prop" : {
      "x" : 196,
      "y" : 131,
      "width" : 71,
      "height" : 30
    },
    "textPosition" : {
      "x" : 205,
      "y" : 135
    },
    "connectors" : [ {
      "edgeId" : 86922,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 231,
          "y" : 125
        },
        "to" : {
          "x" : 232,
          "y" : 91
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 86925,
    "reactomeId" : 10179115,
    "displayName" : "RHOA,RHOB,RHOC,RAC1:GTP:PKN1-3",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 370,
      "y" : 26
    },
    "minX" : 276,
    "maxX" : 471,
    "minY" : 0,
    "maxY" : 59,
    "prop" : {
      "x" : 276,
      "y" : 6,
      "width" : 189,
      "height" : 40
    },
    "textPosition" : {
      "x" : 277,
      "y" : 11
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 465,
          "y" : 6
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 465,
          "y" : 6
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 86922,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 86926,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 426,
          "y" : 49
        },
        "to" : {
          "x" : 463,
          "y" : 59
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 86924,
    "reactomeId" : 10179113,
    "displayName" : "RHOA,RHOB,RHOC,RAC1:GTP",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 135,
      "y" : 28
    },
    "minX" : 42,
    "maxX" : 662,
    "minY" : 8,
    "maxY" : 191,
    "prop" : {
      "x" : 42,
      "y" : 14,
      "width" : 187,
      "height" : 28
    },
    "textPosition" : {
      "x" : 44,
      "y" : 21
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 229,
          "y" : 14
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 229,
          "y" : 14
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 86929,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 138,
          "y" : 45
        },
        "to" : {
          "x" : 171,
          "y" : 191
        }
      }, {
        "from" : {
          "x" : 171,
          "y" : 191
        },
        "to" : {
          "x" : 580,
          "y" : 186
        }
      }, {
        "from" : {
          "x" : 580,
          "y" : 186
        },
        "to" : {
          "x" : 662,
          "y" : 99
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 143,
          "y" : 51
        },
        "b" : {
          "x" : 138,
          "y" : 45
        },
        "c" : {
          "x" : 136,
          "y" : 53
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 136,
          "y" : 53
        }
      }
    }, {
      "edgeId" : 86922,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 156,
          "y" : 45
        },
        "to" : {
          "x" : 232,
          "y" : 91
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 86927,
    "reactomeId" : 10111304,
    "displayName" : "PDPK1:PIP3",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 521,
      "y" : 23
    },
    "minX" : 463,
    "maxX" : 662,
    "minY" : 6,
    "maxY" : 99,
    "prop" : {
      "x" : 481,
      "y" : 12,
      "width" : 80,
      "height" : 22
    },
    "textPosition" : {
      "x" : 481,
      "y" : 13
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 561,
          "y" : 12
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 561,
          "y" : 12
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 86929,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 541,
          "y" : 37
        },
        "to" : {
          "x" : 662,
          "y" : 99
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 549,
          "y" : 37
        },
        "b" : {
          "x" : 541,
          "y" : 37
        },
        "c" : {
          "x" : 545,
          "y" : 44
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 545,
          "y" : 44
        }
      }
    }, {
      "edgeId" : 86926,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 503,
          "y" : 37
        },
        "to" : {
          "x" : 463,
          "y" : 59
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 86928,
    "reactomeId" : 10179119,
    "displayName" : "RHOA,RHOB,RHOC,RAC1:GTP:PKN1-3:PDPK1:PIP3",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 462,
      "y" : 109
    },
    "minX" : 363,
    "maxX" : 602,
    "minY" : 74,
    "maxY" : 129,
    "prop" : {
      "x" : 363,
      "y" : 90,
      "width" : 198,
      "height" : 39
    },
    "textPosition" : {
      "x" : 369,
      "y" : 94
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 561,
          "y" : 90
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 561,
          "y" : 90
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 86929,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 564,
          "y" : 103
        },
        "to" : {
          "x" : 586,
          "y" : 102
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 86929,
      "type" : "CATALYST",
      "segments" : [ {
        "from" : {
          "x" : 515,
          "y" : 87
        },
        "to" : {
          "x" : 558,
          "y" : 74
        }
      }, {
        "from" : {
          "x" : 558,
          "y" : 74
        },
        "to" : {
          "x" : 594,
          "y" : 95
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 598,
          "y" : 97
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 598,
          "y" : 97
        }
      }
    }, {
      "edgeId" : 86926,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 86931,
    "reactomeId" : 10179136,
    "displayName" : "p-T774-PKN1,p-T816-PKN2,p-T718-PKN3",
    "schemaClass" : "DefinedSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 655,
      "y" : 219
    },
    "minX" : 603,
    "maxX" : 707,
    "minY" : 99,
    "maxY" : 247,
    "prop" : {
      "x" : 603,
      "y" : 191,
      "width" : 104,
      "height" : 56
    },
    "textPosition" : {
      "x" : 603,
      "y" : 194
    },
    "connectors" : [ {
      "edgeId" : 86929,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 656,
          "y" : 185
        },
        "to" : {
          "x" : 662,
          "y" : 99
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 652,
          "y" : 178
        },
        "b" : {
          "x" : 656,
          "y" : 185
        },
        "c" : {
          "x" : 660,
          "y" : 178
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 660,
          "y" : 178
        }
      }
    } ]
  }, {
    "id" : 86930,
    "reactomeId" : 113592,
    "displayName" : "ATP",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 572,
      "y" : 141
    },
    "minX" : 550,
    "maxX" : 596,
    "minY" : 102,
    "maxY" : 153,
    "prop" : {
      "x" : 550,
      "y" : 130,
      "width" : 45,
      "height" : 23
    },
    "textPosition" : {
      "x" : 557,
      "y" : 131
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 590,
          "y" : 135
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 590,
          "y" : 135
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 86929,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 576,
          "y" : 127
        },
        "to" : {
          "x" : 586,
          "y" : 102
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 86932,
    "reactomeId" : 29370,
    "displayName" : "ADP",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 703,
      "y" : 148
    },
    "minX" : 662,
    "maxX" : 725,
    "minY" : 99,
    "maxY" : 159,
    "prop" : {
      "x" : 683,
      "y" : 137,
      "width" : 41,
      "height" : 22
    },
    "textPosition" : {
      "x" : 687,
      "y" : 137
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 719,
          "y" : 142
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 719,
          "y" : 142
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 86929,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 693,
          "y" : 134
        },
        "to" : {
          "x" : 662,
          "y" : 99
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 685,
          "y" : 131
        },
        "b" : {
          "x" : 693,
          "y" : 134
        },
        "c" : {
          "x" : 691,
          "y" : 126
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 691,
          "y" : 126
        }
      }
    } ]
  }, {
    "id" : 86935,
    "reactomeId" : 10179131,
    "displayName" : "phospho-p-T774-PKN1",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 657,
      "y" : 290
    },
    "minX" : 372,
    "maxX" : 870,
    "minY" : 273,
    "maxY" : 389,
    "prop" : {
      "x" : 610,
      "y" : 279,
      "width" : 95,
      "height" : 22
    },
    "textPosition" : {
      "x" : 618,
      "y" : 273
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 705,
          "y" : 279
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 705,
          "y" : 279
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 86944,
      "type" : "CATALYST",
      "segments" : [ {
        "from" : {
          "x" : 708,
          "y" : 291
        },
        "to" : {
          "x" : 862,
          "y" : 298
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 866,
          "y" : 298
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 866,
          "y" : 298
        }
      }
    }, {
      "edgeId" : 86933,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 607,
          "y" : 290
        },
        "to" : {
          "x" : 496,
          "y" : 292
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 86937,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 637,
          "y" : 304
        },
        "to" : {
          "x" : 526,
          "y" : 363
        }
      }, {
        "from" : {
          "x" : 526,
          "y" : 363
        },
        "to" : {
          "x" : 372,
          "y" : 389
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 633,
          "y" : 311
        },
        "b" : {
          "x" : 637,
          "y" : 304
        },
        "c" : {
          "x" : 629,
          "y" : 304
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 629,
          "y" : 304
        }
      }
    } ]
  }, {
    "id" : 86934,
    "reactomeId" : 10114574,
    "displayName" : "Cdc25c",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 461,
      "y" : 249
    },
    "minX" : 431,
    "maxX" : 497,
    "minY" : 232,
    "maxY" : 292,
    "prop" : {
      "x" : 431,
      "y" : 238,
      "width" : 60,
      "height" : 23
    },
    "textPosition" : {
      "x" : 434,
      "y" : 239
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 491,
          "y" : 238
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 491,
          "y" : 238
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 86933,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 470,
          "y" : 264
        },
        "to" : {
          "x" : 496,
          "y" : 292
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 86936,
    "reactomeId" : 10182091,
    "displayName" : "p-T774-PKN1:CDC25C",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 375,
      "y" : 296
    },
    "minX" : 325,
    "maxX" : 431,
    "minY" : 273,
    "maxY" : 363,
    "prop" : {
      "x" : 325,
      "y" : 279,
      "width" : 100,
      "height" : 34
    },
    "textPosition" : {
      "x" : 329,
      "y" : 278
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 425,
          "y" : 279
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 425,
          "y" : 279
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 86933,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 86937,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 373,
          "y" : 316
        },
        "to" : {
          "x" : 372,
          "y" : 342
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 86937,
      "type" : "CATALYST",
      "segments" : [ {
        "from" : {
          "x" : 360,
          "y" : 316
        },
        "to" : {
          "x" : 339,
          "y" : 338
        }
      }, {
        "from" : {
          "x" : 339,
          "y" : 338
        },
        "to" : {
          "x" : 360,
          "y" : 356
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 363,
          "y" : 359
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 363,
          "y" : 359
        }
      }
    } ]
  }, {
    "id" : 86939,
    "reactomeId" : 10108797,
    "displayName" : "phospho-Cdc25c",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 374,
      "y" : 437
    },
    "minX" : 253,
    "maxX" : 437,
    "minY" : 388,
    "maxY" : 450,
    "prop" : {
      "x" : 317,
      "y" : 425,
      "width" : 114,
      "height" : 25
    },
    "textPosition" : {
      "x" : 317,
      "y" : 427
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 431,
          "y" : 425
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 431,
          "y" : 425
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 86937,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 373,
          "y" : 422
        },
        "to" : {
          "x" : 372,
          "y" : 389
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 369,
          "y" : 415
        },
        "b" : {
          "x" : 373,
          "y" : 422
        },
        "c" : {
          "x" : 377,
          "y" : 415
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 377,
          "y" : 415
        }
      }
    }, {
      "edgeId" : 86941,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 343,
          "y" : 422
        },
        "to" : {
          "x" : 253,
          "y" : 388
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 86938,
    "reactomeId" : 113592,
    "displayName" : "ATP",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 432,
      "y" : 347
    },
    "minX" : 372,
    "maxX" : 454,
    "minY" : 334,
    "maxY" : 359,
    "prop" : {
      "x" : 412,
      "y" : 335,
      "width" : 41,
      "height" : 24
    },
    "textPosition" : {
      "x" : 417,
      "y" : 336
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 448,
          "y" : 340
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 448,
          "y" : 340
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 86937,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 409,
          "y" : 345
        },
        "to" : {
          "x" : 372,
          "y" : 342
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 86940,
    "reactomeId" : 29370,
    "displayName" : "ADP",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 430,
      "y" : 402
    },
    "minX" : 372,
    "maxX" : 454,
    "minY" : 389,
    "maxY" : 413,
    "prop" : {
      "x" : 408,
      "y" : 391,
      "width" : 45,
      "height" : 22
    },
    "textPosition" : {
      "x" : 414,
      "y" : 391
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 448,
          "y" : 396
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 448,
          "y" : 396
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 86937,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 405,
          "y" : 396
        },
        "to" : {
          "x" : 372,
          "y" : 389
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 397,
          "y" : 398
        },
        "b" : {
          "x" : 405,
          "y" : 396
        },
        "c" : {
          "x" : 399,
          "y" : 391
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 399,
          "y" : 391
        }
      }
    } ]
  }, {
    "id" : 86943,
    "reactomeId" : 10108857,
    "displayName" : "p-S216-CDC25C:14-3-3 protein complex",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 144,
      "y" : 445
    },
    "minX" : 86,
    "maxX" : 208,
    "minY" : 414,
    "maxY" : 471,
    "prop" : {
      "x" : 86,
      "y" : 420,
      "width" : 116,
      "height" : 51
    },
    "textPosition" : {
      "x" : 89,
      "y" : 422
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 202,
          "y" : 420
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 202,
          "y" : 420
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 86941,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 86942,
    "reactomeId" : 10108855,
    "displayName" : "14-3-3 dimer",
    "schemaClass" : "DefinedSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 254,
      "y" : 338
    },
    "minX" : 208,
    "maxX" : 301,
    "minY" : 327,
    "maxY" : 388,
    "prop" : {
      "x" : 208,
      "y" : 327,
      "width" : 93,
      "height" : 22
    },
    "textPosition" : {
      "x" : 211,
      "y" : 327
    },
    "connectors" : [ {
      "edgeId" : 86941,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 253,
          "y" : 355
        },
        "to" : {
          "x" : 253,
          "y" : 388
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 86945,
    "reactomeId" : 10182103,
    "displayName" : "Ppp1r14a",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 879,
      "y" : 223
    },
    "minX" : 843,
    "maxX" : 922,
    "minY" : 206,
    "maxY" : 270,
    "prop" : {
      "x" : 843,
      "y" : 212,
      "width" : 73,
      "height" : 22
    },
    "textPosition" : {
      "x" : 845,
      "y" : 212
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 916,
          "y" : 212
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 916,
          "y" : 212
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 86944,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 878,
          "y" : 237
        },
        "to" : {
          "x" : 878,
          "y" : 270
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 86947,
    "reactomeId" : 29370,
    "displayName" : "ADP",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 933,
      "y" : 333
    },
    "minX" : 877,
    "maxX" : 957,
    "minY" : 320,
    "maxY" : 346,
    "prop" : {
      "x" : 911,
      "y" : 321,
      "width" : 45,
      "height" : 25
    },
    "textPosition" : {
      "x" : 917,
      "y" : 323
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 951,
          "y" : 326
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 951,
          "y" : 326
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 86944,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 908,
          "y" : 332
        },
        "to" : {
          "x" : 877,
          "y" : 331
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 901,
          "y" : 336
        },
        "b" : {
          "x" : 908,
          "y" : 332
        },
        "c" : {
          "x" : 901,
          "y" : 328
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 901,
          "y" : 328
        }
      }
    } ]
  }, {
    "id" : 86946,
    "reactomeId" : 113592,
    "displayName" : "ATP",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 929,
      "y" : 273
    },
    "minX" : 878,
    "maxX" : 953,
    "minY" : 260,
    "maxY" : 285,
    "prop" : {
      "x" : 906,
      "y" : 261,
      "width" : 46,
      "height" : 24
    },
    "textPosition" : {
      "x" : 913,
      "y" : 262
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 947,
          "y" : 266
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 947,
          "y" : 266
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 86944,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 903,
          "y" : 271
        },
        "to" : {
          "x" : 878,
          "y" : 270
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 86948,
    "reactomeId" : 10182106,
    "displayName" : "phospho-Ppp1r14a",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 877,
      "y" : 385
    },
    "minX" : 818,
    "maxX" : 943,
    "minY" : 331,
    "maxY" : 514,
    "prop" : {
      "x" : 818,
      "y" : 373,
      "width" : 119,
      "height" : 24
    },
    "textPosition" : {
      "x" : 843,
      "y" : 368
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 937,
          "y" : 373
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 937,
          "y" : 373
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 86944,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 877,
          "y" : 370
        },
        "to" : {
          "x" : 877,
          "y" : 331
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 873,
          "y" : 363
        },
        "b" : {
          "x" : 877,
          "y" : 370
        },
        "c" : {
          "x" : 881,
          "y" : 363
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 881,
          "y" : 363
        }
      }
    }, {
      "edgeId" : 86949,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 876,
          "y" : 400
        },
        "to" : {
          "x" : 868,
          "y" : 514
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 86951,
    "reactomeId" : 10182111,
    "displayName" : "MLCP:p-T38-PPP1R14A",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 999,
      "y" : 510
    },
    "minX" : 921,
    "maxX" : 1083,
    "minY" : 492,
    "maxY" : 523,
    "prop" : {
      "x" : 921,
      "y" : 498,
      "width" : 156,
      "height" : 25
    },
    "textPosition" : {
      "x" : 925,
      "y" : 502
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1077,
          "y" : 498
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1077,
          "y" : 498
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 86949,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 86950,
    "reactomeId" : 10182000,
    "displayName" : "Myosin phosphatase",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 868,
      "y" : 594
    },
    "minX" : 822,
    "maxX" : 920,
    "minY" : 514,
    "maxY" : 612,
    "prop" : {
      "x" : 822,
      "y" : 576,
      "width" : 92,
      "height" : 36
    },
    "textPosition" : {
      "x" : 822,
      "y" : 577
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 914,
          "y" : 576
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 914,
          "y" : 576
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 86949,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 868,
          "y" : 573
        },
        "to" : {
          "x" : 868,
          "y" : 514
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 86955,
    "reactomeId" : 10222553,
    "displayName" : "PIP3 activates AKT signaling",
    "schemaClass" : "Pathway",
    "renderableClass" : "EncapsulatedNode",
    "position" : {
      "x" : 738,
      "y" : 55
    },
    "minX" : 669,
    "maxX" : 808,
    "minY" : 28,
    "maxY" : 83,
    "prop" : {
      "x" : 669,
      "y" : 28,
      "width" : 139,
      "height" : 55
    },
    "textPosition" : {
      "x" : 671,
      "y" : 34
    },
    "connectors" : [ ]
  }, {
    "id" : 86954,
    "reactomeId" : 10224809,
    "displayName" : "RHO GTPases activate CIT",
    "schemaClass" : "Pathway",
    "renderableClass" : "EncapsulatedNode",
    "position" : {
      "x" : 65,
      "y" : 236
    },
    "minX" : 0,
    "maxX" : 131,
    "minY" : 209,
    "maxY" : 263,
    "prop" : {
      "x" : 0,
      "y" : 209,
      "width" : 131,
      "height" : 54
    },
    "textPosition" : {
      "x" : 13,
      "y" : 214
    },
    "connectors" : [ ]
  }, {
    "id" : 86957,
    "reactomeId" : 10221977,
    "displayName" : "Cell Cycle Checkpoints",
    "schemaClass" : "Pathway",
    "renderableClass" : "EncapsulatedNode",
    "position" : {
      "x" : 375,
      "y" : 540
    },
    "minX" : 322,
    "maxX" : 428,
    "minY" : 512,
    "maxY" : 568,
    "prop" : {
      "x" : 322,
      "y" : 512,
      "width" : 106,
      "height" : 56
    },
    "textPosition" : {
      "x" : 328,
      "y" : 518
    },
    "connectors" : [ ]
  }, {
    "id" : 86956,
    "reactomeId" : 10222655,
    "displayName" : "Mitotic G2-G2/M phases",
    "schemaClass" : "Pathway",
    "renderableClass" : "EncapsulatedNode",
    "position" : {
      "x" : 326,
      "y" : 232
    },
    "minX" : 259,
    "maxX" : 394,
    "minY" : 206,
    "maxY" : 258,
    "prop" : {
      "x" : 259,
      "y" : 206,
      "width" : 135,
      "height" : 52
    },
    "textPosition" : {
      "x" : 268,
      "y" : 210
    },
    "connectors" : [ ]
  }, {
    "id" : 86961,
    "reactomeId" : 10224725,
    "displayName" : "Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3",
    "schemaClass" : "Pathway",
    "renderableClass" : "ProcessNode",
    "position" : {
      "x" : 675,
      "y" : 514
    },
    "minX" : 568,
    "maxX" : 782,
    "minY" : 460,
    "maxY" : 569,
    "prop" : {
      "x" : 568,
      "y" : 460,
      "width" : 214,
      "height" : 109
    },
    "textPosition" : {
      "x" : 572,
      "y" : 479
    },
    "connectors" : [ ]
  } ],
  "edges" : [ {
    "id" : 86929,
    "reactomeId" : 10179139,
    "displayName" : "PDPK1 phosphorylates PKN1,2,3",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 608,
      "y" : 103
    },
    "minX" : 586,
    "maxX" : 662,
    "minY" : 97,
    "maxY" : 109,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 586,
        "y" : 102
      },
      "to" : {
        "x" : 608,
        "y" : 103
      }
    }, {
      "from" : {
        "x" : 608,
        "y" : 103
      },
      "to" : {
        "x" : 662,
        "y" : 99
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 602,
        "y" : 97
      },
      "b" : {
        "x" : 614,
        "y" : 109
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 608,
        "y" : 103
      }
    },
    "inputs" : [ {
      "id" : 86930,
      "points" : [ {
        "x" : 576,
        "y" : 127
      } ]
    }, {
      "id" : 86928,
      "points" : [ {
        "x" : 564,
        "y" : 103
      } ]
    } ],
    "outputs" : [ {
      "id" : 86931,
      "points" : [ {
        "x" : 656,
        "y" : 185
      } ]
    }, {
      "id" : 86924,
      "points" : [ {
        "x" : 138,
        "y" : 45
      }, {
        "x" : 171,
        "y" : 191
      }, {
        "x" : 580,
        "y" : 186
      } ]
    }, {
      "id" : 86927,
      "points" : [ {
        "x" : 541,
        "y" : 37
      } ]
    }, {
      "id" : 86932,
      "points" : [ {
        "x" : 693,
        "y" : 134
      } ]
    } ],
    "catalysts" : [ {
      "id" : 86928,
      "points" : [ {
        "x" : 515,
        "y" : 87
      }, {
        "x" : 558,
        "y" : 74
      } ]
    } ]
  }, {
    "id" : 86944,
    "reactomeId" : 10182109,
    "displayName" : "p-T774-PKN1 phosphorylates PPP1R14A",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 878,
      "y" : 299
    },
    "minX" : 872,
    "maxX" : 884,
    "minY" : 270,
    "maxY" : 331,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 878,
        "y" : 270
      },
      "to" : {
        "x" : 878,
        "y" : 299
      }
    }, {
      "from" : {
        "x" : 878,
        "y" : 299
      },
      "to" : {
        "x" : 877,
        "y" : 331
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 872,
        "y" : 293
      },
      "b" : {
        "x" : 884,
        "y" : 305
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 878,
        "y" : 299
      }
    },
    "inputs" : [ {
      "id" : 86945,
      "points" : [ {
        "x" : 878,
        "y" : 237
      } ]
    }, {
      "id" : 86946,
      "points" : [ {
        "x" : 903,
        "y" : 271
      } ]
    } ],
    "outputs" : [ {
      "id" : 86947,
      "points" : [ {
        "x" : 908,
        "y" : 332
      } ]
    }, {
      "id" : 86948,
      "points" : [ {
        "x" : 877,
        "y" : 370
      } ]
    } ],
    "catalysts" : [ {
      "id" : 86935,
      "points" : [ {
        "x" : 708,
        "y" : 291
      } ]
    } ]
  }, {
    "id" : 86933,
    "reactomeId" : 10182093,
    "displayName" : "p-T774-PKN1 binds CDC25C",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 462,
      "y" : 293
    },
    "minX" : 428,
    "maxX" : 502,
    "minY" : 286,
    "maxY" : 298,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 496,
        "y" : 292
      },
      "to" : {
        "x" : 462,
        "y" : 293
      }
    }, {
      "from" : {
        "x" : 462,
        "y" : 293
      },
      "to" : {
        "x" : 428,
        "y" : 294
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 435,
        "y" : 290
      },
      "b" : {
        "x" : 428,
        "y" : 294
      },
      "c" : {
        "x" : 435,
        "y" : 298
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 435,
        "y" : 298
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 462,
        "y" : 293
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 462,
        "y" : 293
      }
    },
    "inputs" : [ {
      "id" : 86934,
      "points" : [ {
        "x" : 470,
        "y" : 264
      } ]
    }, {
      "id" : 86935,
      "points" : [ {
        "x" : 607,
        "y" : 290
      } ]
    } ],
    "outputs" : [ {
      "id" : 86936
    } ]
  }, {
    "id" : 86949,
    "reactomeId" : 10182113,
    "displayName" : "p-T38-PPP1R14A binds MLCP",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 868,
      "y" : 515
    },
    "minX" : 862,
    "maxX" : 918,
    "minY" : 509,
    "maxY" : 521,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 868,
        "y" : 514
      },
      "to" : {
        "x" : 868,
        "y" : 515
      }
    }, {
      "from" : {
        "x" : 868,
        "y" : 515
      },
      "to" : {
        "x" : 918,
        "y" : 512
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 911,
        "y" : 516
      },
      "b" : {
        "x" : 918,
        "y" : 512
      },
      "c" : {
        "x" : 911,
        "y" : 508
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 911,
        "y" : 508
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 868,
        "y" : 515
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 868,
        "y" : 515
      }
    },
    "inputs" : [ {
      "id" : 86950,
      "points" : [ {
        "x" : 868,
        "y" : 573
      } ]
    }, {
      "id" : 86948,
      "points" : [ {
        "x" : 876,
        "y" : 400
      } ]
    } ],
    "outputs" : [ {
      "id" : 86951
    } ]
  }, {
    "id" : 86937,
    "reactomeId" : 10182096,
    "displayName" : "p-T774-PKN1 phosphorylates CDC25C",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 372,
      "y" : 367
    },
    "minX" : 366,
    "maxX" : 378,
    "minY" : 342,
    "maxY" : 389,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 372,
        "y" : 342
      },
      "to" : {
        "x" : 372,
        "y" : 367
      }
    }, {
      "from" : {
        "x" : 372,
        "y" : 367
      },
      "to" : {
        "x" : 372,
        "y" : 389
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 366,
        "y" : 361
      },
      "b" : {
        "x" : 378,
        "y" : 373
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 372,
        "y" : 367
      }
    },
    "inputs" : [ {
      "id" : 86936,
      "points" : [ {
        "x" : 373,
        "y" : 316
      } ]
    }, {
      "id" : 86938,
      "points" : [ {
        "x" : 409,
        "y" : 345
      } ]
    } ],
    "outputs" : [ {
      "id" : 86939,
      "points" : [ {
        "x" : 373,
        "y" : 422
      } ]
    }, {
      "id" : 86935,
      "points" : [ {
        "x" : 637,
        "y" : 304
      }, {
        "x" : 526,
        "y" : 363
      } ]
    }, {
      "id" : 86940,
      "points" : [ {
        "x" : 405,
        "y" : 396
      } ]
    } ],
    "catalysts" : [ {
      "id" : 86936,
      "points" : [ {
        "x" : 360,
        "y" : 316
      }, {
        "x" : 339,
        "y" : 338
      } ]
    } ]
  }, {
    "id" : 86922,
    "reactomeId" : 10179117,
    "displayName" : "RHOA, RHOB, RHOC and RAC1 bind PKN1, PKN2 or PKN3",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 232,
      "y" : 90
    },
    "minX" : 226,
    "maxX" : 326,
    "minY" : 49,
    "maxY" : 96,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 232,
        "y" : 91
      },
      "to" : {
        "x" : 232,
        "y" : 90
      }
    }, {
      "from" : {
        "x" : 232,
        "y" : 90
      },
      "to" : {
        "x" : 326,
        "y" : 49
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 321,
        "y" : 55
      },
      "b" : {
        "x" : 326,
        "y" : 49
      },
      "c" : {
        "x" : 318,
        "y" : 48
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 318,
        "y" : 48
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 232,
        "y" : 90
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 232,
        "y" : 90
      }
    },
    "inputs" : [ {
      "id" : 86923,
      "points" : [ {
        "x" : 231,
        "y" : 125
      } ]
    }, {
      "id" : 86924,
      "points" : [ {
        "x" : 156,
        "y" : 45
      } ]
    } ],
    "outputs" : [ {
      "id" : 86925
    } ]
  }, {
    "id" : 86941,
    "reactomeId" : 10108859,
    "displayName" : "Association of p-S216-CDC25C with 14-3-3 proteins",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 255,
      "y" : 388
    },
    "minX" : 193,
    "maxX" : 261,
    "minY" : 382,
    "maxY" : 417,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 253,
        "y" : 388
      },
      "to" : {
        "x" : 255,
        "y" : 388
      }
    }, {
      "from" : {
        "x" : 255,
        "y" : 388
      },
      "to" : {
        "x" : 193,
        "y" : 417
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 198,
        "y" : 410
      },
      "b" : {
        "x" : 193,
        "y" : 417
      },
      "c" : {
        "x" : 201,
        "y" : 418
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 201,
        "y" : 418
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 255,
        "y" : 388
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 255,
        "y" : 388
      }
    },
    "inputs" : [ {
      "id" : 86939,
      "points" : [ {
        "x" : 343,
        "y" : 422
      } ]
    }, {
      "id" : 86942,
      "points" : [ {
        "x" : 253,
        "y" : 355
      } ]
    } ],
    "outputs" : [ {
      "id" : 86943
    } ]
  }, {
    "id" : 86926,
    "reactomeId" : 10179121,
    "displayName" : "RHOA,RHOB,RHOC,RAC1:GTP:PKN1,2,3 binds PDPK1:PIP3",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 463,
      "y" : 60
    },
    "minX" : 457,
    "maxX" : 469,
    "minY" : 54,
    "maxY" : 87,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 463,
        "y" : 59
      },
      "to" : {
        "x" : 463,
        "y" : 60
      }
    }, {
      "from" : {
        "x" : 463,
        "y" : 60
      },
      "to" : {
        "x" : 462,
        "y" : 87
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 458,
        "y" : 80
      },
      "b" : {
        "x" : 462,
        "y" : 87
      },
      "c" : {
        "x" : 466,
        "y" : 80
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 466,
        "y" : 80
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 463,
        "y" : 60
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 463,
        "y" : 60
      }
    },
    "inputs" : [ {
      "id" : 86925,
      "points" : [ {
        "x" : 426,
        "y" : 49
      } ]
    }, {
      "id" : 86927,
      "points" : [ {
        "x" : 503,
        "y" : 37
      } ]
    } ],
    "outputs" : [ {
      "id" : 86928
    } ]
  } ],
  "compartments" : [ {
    "id" : 86953,
    "reactomeId" : 7660,
    "displayName" : "nucleoplasm",
    "schemaClass" : "Compartment",
    "renderableClass" : "Compartment",
    "position" : {
      "x" : 634,
      "y" : 526
    },
    "minX" : 464,
    "maxX" : 804,
    "minY" : 435,
    "maxY" : 617,
    "prop" : {
      "x" : 464,
      "y" : 435,
      "width" : 340,
      "height" : 182
    },
    "textPosition" : {
      "x" : 477,
      "y" : 567
    },
    "insets" : {
      "x" : 474,
      "y" : 445,
      "width" : 320,
      "height" : 162
    },
    "bgColor" : {
      "r" : 250,
      "g" : 240,
      "b" : 240
    },
    "componentIds" : [ 86961 ]
  }, {
    "id" : 86952,
    "reactomeId" : 70101,
    "displayName" : "cytosol",
    "schemaClass" : "Compartment",
    "renderableClass" : "Compartment",
    "position" : {
      "x" : 564,
      "y" : 386
    },
    "minX" : 21,
    "maxX" : 1108,
    "minY" : 19,
    "maxY" : 754,
    "prop" : {
      "x" : 21,
      "y" : 19,
      "width" : 1087,
      "height" : 735
    },
    "textPosition" : {
      "x" : 42,
      "y" : 583
    },
    "insets" : {
      "x" : 31,
      "y" : 29,
      "width" : 1067,
      "height" : 715
    },
    "bgColor" : {
      "r" : 250,
      "g" : 240,
      "b" : 240
    },
    "componentIds" : [ 86922, 86923, 86924, 86925, 86926, 86927, 86928, 86929, 86930, 86931, 86932, 86935, 86962, 86953, 86954, 86963, 86955, 86964, 86933, 86934, 86936, 86937, 86938, 86939, 86940, 86941, 86943, 86942, 86956, 86965, 86957, 86966, 86946, 86947, 86944, 86948, 86945, 86949, 86950, 86951, 86967 ]
  } ],
  "notes" : [ ],
  "links" : [ {
    "id" : 86963,
    "renderableClass" : "Interaction",
    "position" : {
      "x" : 102,
      "y" : 125
    },
    "minX" : 74,
    "maxX" : 130,
    "minY" : 45,
    "maxY" : 206,
    "interactionType" : "Activate",
    "segments" : [ {
      "from" : {
        "x" : 130,
        "y" : 45
      },
      "to" : {
        "x" : 74,
        "y" : 206
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 72,
        "y" : 198
      },
      "b" : {
        "x" : 74,
        "y" : 206
      },
      "c" : {
        "x" : 80,
        "y" : 201
      },
      "type" : "ARROW",
      "empty" : true,
      "centre" : {
        "x" : 80,
        "y" : 201
      }
    },
    "reactionShape" : {
      "a" : {
        "x" : 96,
        "y" : 119
      },
      "b" : {
        "x" : 108,
        "y" : 131
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 102,
        "y" : 125
      }
    },
    "inputs" : [ {
      "id" : 86924
    } ],
    "outputs" : [ {
      "id" : 86954
    } ]
  }, {
    "id" : 86962,
    "renderableClass" : "EntitySetAndMemberLink",
    "position" : {
      "x" : 655,
      "y" : 264
    },
    "minX" : 649,
    "maxX" : 661,
    "minY" : 253,
    "maxY" : 276,
    "segments" : [ {
      "from" : {
        "x" : 656,
        "y" : 276
      },
      "to" : {
        "x" : 655,
        "y" : 253
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 649,
        "y" : 258
      },
      "b" : {
        "x" : 661,
        "y" : 270
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 655,
        "y" : 264
      }
    },
    "inputs" : [ {
      "id" : 86935
    } ],
    "outputs" : [ {
      "id" : 86931
    } ]
  }, {
    "id" : 86965,
    "renderableClass" : "Interaction",
    "position" : {
      "x" : 412,
      "y" : 241
    },
    "minX" : 397,
    "maxX" : 428,
    "minY" : 235,
    "maxY" : 247,
    "interactionType" : "Activate",
    "segments" : [ {
      "from" : {
        "x" : 428,
        "y" : 244
      },
      "to" : {
        "x" : 397,
        "y" : 239
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 404,
        "y" : 236
      },
      "b" : {
        "x" : 397,
        "y" : 239
      },
      "c" : {
        "x" : 403,
        "y" : 244
      },
      "type" : "ARROW",
      "empty" : true,
      "centre" : {
        "x" : 403,
        "y" : 244
      }
    },
    "reactionShape" : {
      "a" : {
        "x" : 406,
        "y" : 235
      },
      "b" : {
        "x" : 418,
        "y" : 247
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 412,
        "y" : 241
      }
    },
    "inputs" : [ {
      "id" : 86934
    } ],
    "outputs" : [ {
      "id" : 86956
    } ]
  }, {
    "id" : 86964,
    "renderableClass" : "Interaction",
    "position" : {
      "x" : 615,
      "y" : 36
    },
    "minX" : 564,
    "maxX" : 666,
    "minY" : 28,
    "maxY" : 44,
    "interactionType" : "Activate",
    "segments" : [ {
      "from" : {
        "x" : 666,
        "y" : 44
      },
      "to" : {
        "x" : 564,
        "y" : 28
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 571,
        "y" : 25
      },
      "b" : {
        "x" : 564,
        "y" : 28
      },
      "c" : {
        "x" : 570,
        "y" : 33
      },
      "type" : "ARROW",
      "empty" : true,
      "centre" : {
        "x" : 570,
        "y" : 33
      }
    },
    "reactionShape" : {
      "a" : {
        "x" : 609,
        "y" : 30
      },
      "b" : {
        "x" : 621,
        "y" : 42
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 615,
        "y" : 36
      }
    },
    "inputs" : [ {
      "id" : 86955
    } ],
    "outputs" : [ {
      "id" : 86927
    } ]
  }, {
    "id" : 86967,
    "renderableClass" : "Interaction",
    "position" : {
      "x" : 663,
      "y" : 380
    },
    "minX" : 657,
    "maxX" : 670,
    "minY" : 304,
    "maxY" : 457,
    "interactionType" : "Activate",
    "segments" : [ {
      "from" : {
        "x" : 657,
        "y" : 304
      },
      "to" : {
        "x" : 670,
        "y" : 457
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 665,
        "y" : 450
      },
      "b" : {
        "x" : 670,
        "y" : 457
      },
      "c" : {
        "x" : 673,
        "y" : 450
      },
      "type" : "ARROW",
      "empty" : true,
      "centre" : {
        "x" : 673,
        "y" : 450
      }
    },
    "reactionShape" : {
      "a" : {
        "x" : 657,
        "y" : 374
      },
      "b" : {
        "x" : 669,
        "y" : 386
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 663,
        "y" : 380
      }
    },
    "inputs" : [ {
      "id" : 86935
    } ],
    "outputs" : [ {
      "id" : 86961
    } ]
  }, {
    "id" : 86966,
    "renderableClass" : "Interaction",
    "position" : {
      "x" : 374,
      "y" : 481
    },
    "minX" : 368,
    "maxX" : 380,
    "minY" : 453,
    "maxY" : 509,
    "interactionType" : "Activate",
    "segments" : [ {
      "from" : {
        "x" : 374,
        "y" : 509
      },
      "to" : {
        "x" : 374,
        "y" : 453
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 378,
        "y" : 460
      },
      "b" : {
        "x" : 374,
        "y" : 453
      },
      "c" : {
        "x" : 370,
        "y" : 460
      },
      "type" : "ARROW",
      "empty" : true,
      "centre" : {
        "x" : 370,
        "y" : 460
      }
    },
    "reactionShape" : {
      "a" : {
        "x" : 368,
        "y" : 475
      },
      "b" : {
        "x" : 380,
        "y" : 487
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 374,
        "y" : 481
      }
    },
    "inputs" : [ {
      "id" : 86957
    } ],
    "outputs" : [ {
      "id" : 86939
    } ]
  } ],
  "shadows" : [ ],
  "minX" : 0,
  "maxX" : 1108,
  "minY" : 0,
  "maxY" : 754,
  "disease" : false
}