{
  "dbId" : 10101943,
  "stId" : "R-MMU-9841251",
  "speciesName" : "Mus musculus",
  "nodes" : [ {
    "dbId" : 10061597,
    "stId" : "R-MMU-1605416",
    "displayName" : "SIRT3(?-399) [mitochondrial matrix]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48892,
    "diagramIds" : [ 77527 ],
    "identifier" : "Q8R104",
    "standardIdentifier" : "uniprot:Q8R104",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "Sirt3", "Sir2l3" ],
    "parents" : [ ],
    "children" : [ ]
  }, {
    "dbId" : 10095388,
    "stId" : "R-MMU-9857081",
    "displayName" : "HSF1:HSPA1A,B [cytosol]",
    "schemaClass" : "Complex",
    "speciesId" : 48892,
    "diagramIds" : [ 77535 ],
    "parents" : [ ],
    "children" : [ 10018897, 10048936 ]
  }, {
    "dbId" : 5688337,
    "stId" : "R-ALL-5688337",
    "displayName" : "2'-O-acetyl-ADP-ribose [mitochondrial matrix]",
    "schemaClass" : "SimpleEntity",
    "speciesId" : 0,
    "diagramIds" : [ 77526 ],
    "identifier" : "83767",
    "standardIdentifier" : "chebi:83767",
    "referenceType" : "ReferenceMolecule",
    "parents" : [ ],
    "children" : [ ]
  }, {
    "dbId" : 10051729,
    "stId" : "R-MMU-5082354",
    "displayName" : "p-S326-HSF1 trimer [nucleoplasm]",
    "schemaClass" : "Complex",
    "speciesId" : 48892,
    "diagramIds" : [ 77540 ],
    "parents" : [ ],
    "children" : [ 10051727 ]
  }, {
    "dbId" : 10018897,
    "stId" : "R-MMU-6792602-3",
    "displayName" : "Homologues of HSPA1A [cytosol]",
    "schemaClass" : "DefinedSet",
    "speciesId" : 48892,
    "parents" : [ 10095394, 10095388 ],
    "children" : [ 10018895, 10018891 ]
  }, {
    "dbId" : 10044180,
    "stId" : "R-MMU-9020968",
    "displayName" : "ESR1 [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48892,
    "identifier" : "P19785",
    "standardIdentifier" : "uniprot:P19785",
    "referenceType" : "ReferenceGeneProduct",
    "parents" : [ 10094520 ],
    "children" : [ ]
  }, {
    "dbId" : 1250243,
    "stId" : "R-ALL-1250243",
    "displayName" : "ROS [cytosol]",
    "schemaClass" : "SimpleEntity",
    "speciesId" : 0,
    "diagramIds" : [ 77532 ],
    "identifier" : "26523",
    "standardIdentifier" : "chebi:26523",
    "referenceType" : "ReferenceMolecule",
    "parents" : [ ],
    "children" : [ ]
  }, {
    "dbId" : 10094536,
    "stId" : "R-MMU-9841942",
    "displayName" : "p-S167-ESR1 dimer [nucleoplasm]",
    "schemaClass" : "Complex",
    "speciesId" : 48892,
    "diagramIds" : [ 77520 ],
    "parents" : [ ],
    "children" : [ 10094534 ]
  }, {
    "dbId" : 10018891,
    "stId" : "R-MMU-6792602",
    "displayName" : "HSPA1A [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48892,
    "identifier" : "P17879",
    "standardIdentifier" : "uniprot:P17879",
    "referenceType" : "ReferenceGeneProduct",
    "parents" : [ 10018897 ],
    "children" : [ ]
  }, {
    "dbId" : 10048909,
    "stId" : "R-MMU-3371544",
    "displayName" : "DNAJA1 [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48892,
    "diagramIds" : [ 77531 ],
    "identifier" : "P63037",
    "standardIdentifier" : "uniprot:P63037",
    "referenceType" : "ReferenceGeneProduct",
    "parents" : [ ],
    "children" : [ ]
  }, {
    "dbId" : 10003085,
    "stId" : "R-MMU-199305",
    "displayName" : "Foxo3 [nucleoplasm]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48892,
    "diagramIds" : [ 77529 ],
    "identifier" : "Q9WVH4",
    "standardIdentifier" : "uniprot:Q9WVH4",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "Foxo3", "Fkhr2", "Foxo3a" ],
    "parents" : [ ],
    "children" : [ ]
  }, {
    "dbId" : 10051727,
    "stId" : "R-MMU-5082355",
    "displayName" : "phospho-Hsf1 [nucleoplasm]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48892,
    "identifier" : "P38532",
    "standardIdentifier" : "uniprot:P38532",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "Hsf1" ],
    "parents" : [ 10051729 ],
    "children" : [ ]
  }, {
    "dbId" : 10094540,
    "stId" : "R-MMU-9841849",
    "displayName" : "Foxo3 [mitochondrial matrix]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48892,
    "diagramIds" : [ 77524 ],
    "identifier" : "Q9WVH4",
    "standardIdentifier" : "uniprot:Q9WVH4",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "Foxo3", "Fkhr2", "Foxo3a" ],
    "parents" : [ ],
    "children" : [ ]
  }, {
    "dbId" : 10018895,
    "stId" : "R-MMU-6792602-2",
    "displayName" : "HSPA1A [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48892,
    "identifier" : "Q61696",
    "standardIdentifier" : "uniprot:Q61696",
    "referenceType" : "ReferenceGeneProduct",
    "parents" : [ 10018897 ],
    "children" : [ ]
  }, {
    "dbId" : 10094530,
    "stId" : "R-MMU-9841824",
    "displayName" : "Foxo3 [mitochondrial matrix]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48892,
    "diagramIds" : [ 77525 ],
    "identifier" : "Q9WVH4",
    "standardIdentifier" : "uniprot:Q9WVH4",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "Foxo3", "Fkhr2", "Foxo3a" ],
    "parents" : [ ],
    "children" : [ ]
  }, {
    "dbId" : 10094534,
    "stId" : "R-MMU-9841867",
    "displayName" : "phospho-p-S167-ESR1 [nucleoplasm]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48892,
    "identifier" : "P19785",
    "standardIdentifier" : "uniprot:P19785",
    "referenceType" : "ReferenceGeneProduct",
    "parents" : [ 10094536 ],
    "children" : [ ]
  }, {
    "dbId" : 10094523,
    "stId" : "R-MMU-9841254",
    "displayName" : "phospho-p-S167-ESR1 [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48892,
    "identifier" : "P19785",
    "standardIdentifier" : "uniprot:P19785",
    "referenceType" : "ReferenceGeneProduct",
    "parents" : [ 10094525 ],
    "children" : [ ]
  }, {
    "dbId" : 10094520,
    "stId" : "R-MMU-9841939",
    "displayName" : "ESR1 dimer [cytosol]",
    "schemaClass" : "Complex",
    "speciesId" : 48892,
    "diagramIds" : [ 77515 ],
    "parents" : [ ],
    "children" : [ 10044180 ]
  }, {
    "dbId" : 10094525,
    "stId" : "R-MMU-9841941",
    "displayName" : "p-S167-ESR1 dimer [cytosol]",
    "schemaClass" : "Complex",
    "speciesId" : 48892,
    "diagramIds" : [ 77517 ],
    "parents" : [ ],
    "children" : [ 10094523 ]
  }, {
    "dbId" : 10094516,
    "stId" : "R-MMU-9841264",
    "displayName" : "phospho-p-S473-AKT1 [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48892,
    "diagramIds" : [ 77513 ],
    "identifier" : "P31750",
    "standardIdentifier" : "uniprot:P31750",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "Akt1", "Akt", "Rac" ],
    "parents" : [ ],
    "children" : [ ]
  }, {
    "dbId" : 113521,
    "stId" : "R-ALL-113521",
    "displayName" : "H2O [mitochondrial matrix]",
    "schemaClass" : "SimpleEntity",
    "speciesId" : 0,
    "diagramIds" : [ 77522 ],
    "identifier" : "15377",
    "standardIdentifier" : "chebi:15377",
    "referenceType" : "ReferenceMolecule",
    "parents" : [ ],
    "children" : [ ]
  }, {
    "dbId" : 10048936,
    "stId" : "R-MMU-3371452",
    "displayName" : "Hsf1 [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48892,
    "diagramIds" : [ 77536 ],
    "identifier" : "P38532",
    "standardIdentifier" : "uniprot:P38532",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "Hsf1" ],
    "parents" : [ 10095388 ],
    "children" : [ ]
  }, {
    "dbId" : 113526,
    "stId" : "R-ALL-113526",
    "displayName" : "NAD+ [mitochondrial matrix]",
    "schemaClass" : "SimpleEntity",
    "speciesId" : 0,
    "diagramIds" : [ 77523 ],
    "identifier" : "57540",
    "standardIdentifier" : "chebi:57540",
    "referenceType" : "ReferenceMolecule",
    "parents" : [ ],
    "children" : [ ]
  }, {
    "dbId" : 10095394,
    "stId" : "R-MMU-9857087",
    "displayName" : "HSPA1A,B:ox-C149,C150-DNAJA1 [cytosol]",
    "schemaClass" : "Complex",
    "speciesId" : 48892,
    "diagramIds" : [ 77537 ],
    "parents" : [ ],
    "children" : [ 10095392, 10018897 ]
  }, {
    "dbId" : 113592,
    "stId" : "R-ALL-113592",
    "displayName" : "ATP [cytosol]",
    "schemaClass" : "SimpleEntity",
    "speciesId" : 0,
    "diagramIds" : [ 77539, 77511, 77516 ],
    "identifier" : "30616",
    "standardIdentifier" : "chebi:30616",
    "referenceType" : "ReferenceMolecule",
    "parents" : [ ],
    "children" : [ ]
  }, {
    "dbId" : 29370,
    "stId" : "R-ALL-29370",
    "displayName" : "ADP [cytosol]",
    "schemaClass" : "SimpleEntity",
    "speciesId" : 0,
    "diagramIds" : [ 77541, 77512, 77518 ],
    "identifier" : "456216",
    "standardIdentifier" : "chebi:456216",
    "referenceType" : "ReferenceMolecule",
    "parents" : [ ],
    "children" : [ ]
  }, {
    "dbId" : 10095392,
    "stId" : "R-MMU-9857072",
    "displayName" : "SOH-C149,C150-DNAJA1 [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48892,
    "diagramIds" : [ 77533 ],
    "identifier" : "P63037",
    "standardIdentifier" : "uniprot:P63037",
    "referenceType" : "ReferenceGeneProduct",
    "parents" : [ 10095394 ],
    "children" : [ ]
  }, {
    "dbId" : 10013030,
    "stId" : "R-MMU-58252",
    "displayName" : "AKT1 [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48892,
    "diagramIds" : [ 77510 ],
    "identifier" : "P31750",
    "standardIdentifier" : "uniprot:P31750",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "Akt1", "Akt", "Rac" ],
    "parents" : [ ],
    "children" : [ ]
  } ],
  "edges" : [ {
    "dbId" : 10095402,
    "stId" : "R-MMU-9857091",
    "displayName" : "HSF1 is activated by phosphorylation, translocation to the nucleus, and trimerization",
    "schemaClass" : "BlackBoxEvent",
    "speciesId" : 0,
    "preceding" : [ 10095396 ],
    "inputs" : [ 113592, 10048936 ],
    "outputs" : [ 29370, 10051729 ],
    "efs" : [ ],
    "diagramIds" : [ 77538 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10094538,
    "stId" : "R-MMU-9841817",
    "displayName" : "p-S167-ESR1 translocates from the cytosol to the nucleus",
    "schemaClass" : "BlackBoxEvent",
    "speciesId" : 0,
    "preceding" : [ 10094528 ],
    "inputs" : [ 10094525 ],
    "outputs" : [ 10094536 ],
    "efs" : [ ],
    "diagramIds" : [ 77519 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10095400,
    "stId" : "R-MMU-9857090",
    "displayName" : "Reactive oxygen species oxidize DNAJA1",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "following" : [ 10095396 ],
    "inputs" : [ 10048909, 1250243 ],
    "outputs" : [ 10095392 ],
    "efs" : [ ],
    "diagramIds" : [ 77530 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10094543,
    "stId" : "R-MMU-9841847",
    "displayName" : "SIRT3 deacetylates Ac-K272,K290-FOXO3",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "following" : [ 10094532 ],
    "inputs" : [ 113526, 10094540, 113521 ],
    "outputs" : [ 10094530, 5688337 ],
    "catalysts" : [ 10061597 ],
    "efs" : [ ],
    "diagramIds" : [ 77521 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10094528,
    "stId" : "R-MMU-9841265",
    "displayName" : "p-S473-AKT1 phosphorylates ESR1 on serine-167",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "preceding" : [ 10094518 ],
    "following" : [ 10094538 ],
    "inputs" : [ 113592, 10094520 ],
    "outputs" : [ 29370, 10094525 ],
    "catalysts" : [ 10094516 ],
    "efs" : [ ],
    "diagramIds" : [ 77514 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10094518,
    "stId" : "R-MMU-9841244",
    "displayName" : "Phosphorylation of AKT1 on serine-473 in response to reactive oxygen species",
    "schemaClass" : "BlackBoxEvent",
    "speciesId" : 0,
    "following" : [ 10094528 ],
    "inputs" : [ 10013030, 113592 ],
    "outputs" : [ 10094516, 29370 ],
    "efs" : [ ],
    "diagramIds" : [ 77509 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10095396,
    "stId" : "R-MMU-9857076",
    "displayName" : "Oxidized DNAJA1 binds HSPA1A,B (HSP70) displacing HSF1",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "preceding" : [ 10095400 ],
    "following" : [ 10095402 ],
    "inputs" : [ 10095392, 10095388 ],
    "outputs" : [ 10095394, 10048936 ],
    "efs" : [ ],
    "diagramIds" : [ 77534 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10094532,
    "stId" : "R-MMU-9841812",
    "displayName" : "FOXO3 translocates from the mitochondrial matrix to the nucleus",
    "schemaClass" : "BlackBoxEvent",
    "speciesId" : 0,
    "preceding" : [ 10094543 ],
    "inputs" : [ 10094530 ],
    "outputs" : [ 10003085 ],
    "efs" : [ ],
    "diagramIds" : [ 77528 ],
    "entityFunctionalStatus" : [ ]
  } ]
}