{ "dbId" : 10101929, "stableId" : "R-MMU-9837999", "displayName" : "Mitochondrial protein degradation", "nodes" : [ { "id" : 86027, "reactomeId" : 9995908, "displayName" : "Tfam", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 395, "y" : 69 }, "minX" : 347, "maxX" : 433, "minY" : 51, "maxY" : 96, "prop" : { "x" : 364, "y" : 57, "width" : 63, "height" : 25 }, "textPosition" : { "x" : 376, "y" : 59 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 427, "y" : 57 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 427, "y" : 57 } } }, "connectors" : [ { "edgeId" : 86026, "type" : "INPUT", "segments" : [ { "from" : { "x" : 372, "y" : 85 }, "to" : { "x" : 347, "y" : 96 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 86029, "reactomeId" : 113581, "displayName" : "ADP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 294, "y" : 171 }, "minX" : 273, "maxX" : 350, "minY" : 137, "maxY" : 187, "prop" : { "x" : 273, "y" : 156, "width" : 42, "height" : 31 }, "textPosition" : { "x" : 277, "y" : 161 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 310, "y" : 161 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 310, "y" : 161 } } }, "connectors" : [ { "edgeId" : 86026, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 318, "y" : 158 }, "to" : { "x" : 350, "y" : 137 } } ], "stoichiometry" : { "value" : 4, "shape" : { "a" : { "x" : 328, "y" : 141 }, "b" : { "x" : 340, "y" : 153 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 334, "y" : 147 } } }, "endShape" : { "a" : { "x" : 322, "y" : 151 }, "b" : { "x" : 318, "y" : 158 }, "c" : { "x" : 326, "y" : 158 }, "type" : "ARROW", "centre" : { "x" : 326, "y" : 158 } } } ] }, { "id" : 86028, "reactomeId" : 113593, "displayName" : "ATP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 279, "y" : 77 }, "minX" : 253, "maxX" : 347, "minY" : 59, "maxY" : 96, "prop" : { "x" : 253, "y" : 60, "width" : 53, "height" : 35 }, "textPosition" : { "x" : 264, "y" : 67 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 301, "y" : 65 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 301, "y" : 65 } } }, "connectors" : [ { "edgeId" : 86026, "type" : "INPUT", "segments" : [ { "from" : { "x" : 309, "y" : 84 }, "to" : { "x" : 347, "y" : 96 } } ], "stoichiometry" : { "value" : 4, "shape" : { "a" : { "x" : 322, "y" : 84 }, "b" : { "x" : 334, "y" : 96 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 328, "y" : 90 } } } } ] }, { "id" : 86031, "reactomeId" : 10094320, "displayName" : "PRKACA", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 414, "y" : 111 }, "minX" : 357, "maxX" : 456, "minY" : 91, "maxY" : 126, "prop" : { "x" : 378, "y" : 97, "width" : 72, "height" : 29 }, "textPosition" : { "x" : 386, "y" : 101 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 450, "y" : 97 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 450, "y" : 97 } } }, "connectors" : [ { "edgeId" : 86026, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 375, "y" : 113 }, "to" : { "x" : 365, "y" : 114 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 361, "y" : 114 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 361, "y" : 114 } } } ] }, { "id" : 86030, "reactomeId" : 10094306, "displayName" : "phospho-Tfam", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 440, "y" : 175 }, "minX" : 350, "maxX" : 535, "minY" : 137, "maxY" : 192, "prop" : { "x" : 351, "y" : 159, "width" : 178, "height" : 33 }, "textPosition" : { "x" : 391, "y" : 165 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 529, "y" : 159 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 529, "y" : 159 } } }, "connectors" : [ { "edgeId" : 86026, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 400, "y" : 156 }, "to" : { "x" : 350, "y" : 137 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 392, "y" : 157 }, "b" : { "x" : 400, "y" : 156 }, "c" : { "x" : 395, "y" : 150 }, "type" : "ARROW", "centre" : { "x" : 395, "y" : 150 } } } ] }, { "id" : 86033, "reactomeId" : 10094237, "displayName" : "LONP1 hexamer", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 281, "y" : 296 }, "minX" : 164, "maxX" : 399, "minY" : 277, "maxY" : 522, "prop" : { "x" : 224, "y" : 283, "width" : 115, "height" : 27 }, "textPosition" : { "x" : 228, "y" : 289 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 339, "y" : 283 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 339, "y" : 283 } } }, "connectors" : [ { "edgeId" : 86032, "type" : "INPUT", "segments" : [ { "from" : { "x" : 342, "y" : 303 }, "to" : { "x" : 394, "y" : 311 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 86036, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 281, "y" : 313 }, "to" : { "x" : 290, "y" : 518 } }, { "from" : { "x" : 290, "y" : 518 }, "to" : { "x" : 399, "y" : 518 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 285, "y" : 320 }, "b" : { "x" : 281, "y" : 313 }, "c" : { "x" : 277, "y" : 320 }, "type" : "ARROW", "centre" : { "x" : 277, "y" : 320 } } }, { "edgeId" : 86041, "type" : "INPUT", "segments" : [ { "from" : { "x" : 221, "y" : 305 }, "to" : { "x" : 164, "y" : 316 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 86044, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 281, "y" : 313 }, "to" : { "x" : 281, "y" : 521 } }, { "from" : { "x" : 281, "y" : 521 }, "to" : { "x" : 174, "y" : 522 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 285, "y" : 320 }, "b" : { "x" : 281, "y" : 313 }, "c" : { "x" : 277, "y" : 320 }, "type" : "ARROW", "centre" : { "x" : 277, "y" : 320 } } } ] }, { "id" : 86035, "reactomeId" : 10094310, "displayName" : "LONP1:substrate protein (mitochondrial matrix)", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 398, "y" : 394 }, "minX" : 312, "maxX" : 491, "minY" : 368, "maxY" : 474, "prop" : { "x" : 312, "y" : 374, "width" : 173, "height" : 41 }, "textPosition" : { "x" : 315, "y" : 380 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 485, "y" : 374 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 485, "y" : 374 } } }, "connectors" : [ { "edgeId" : 86032, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 86036, "type" : "INPUT", "segments" : [ { "from" : { "x" : 404, "y" : 418 }, "to" : { "x" : 418, "y" : 457 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 86036, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 398, "y" : 418 }, "to" : { "x" : 400, "y" : 466 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 400, "y" : 470 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 400, "y" : 470 } } } ] }, { "id" : 86034, "reactomeId" : 10094308, "displayName" : "Substrate of LONP1 (mitochondrial matrix)", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 432, "y" : 241 }, "minX" : 342, "maxX" : 522, "minY" : 221, "maxY" : 311, "prop" : { "x" : 342, "y" : 221, "width" : 180, "height" : 41 }, "textPosition" : { "x" : 359, "y" : 224 }, "connectors" : [ { "edgeId" : 86032, "type" : "INPUT", "segments" : [ { "from" : { "x" : 420, "y" : 268 }, "to" : { "x" : 394, "y" : 311 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 86037, "reactomeId" : 113593, "displayName" : "ATP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 474, "y" : 437 }, "minX" : 418, "maxX" : 496, "minY" : 421, "maxY" : 457, "prop" : { "x" : 454, "y" : 422, "width" : 41, "height" : 31 }, "textPosition" : { "x" : 459, "y" : 427 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 490, "y" : 427 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 490, "y" : 427 } } }, "connectors" : [ { "edgeId" : 86036, "type" : "INPUT", "segments" : [ { "from" : { "x" : 451, "y" : 444 }, "to" : { "x" : 418, "y" : 457 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 86039, "reactomeId" : 113581, "displayName" : "ADP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 448, "y" : 551 }, "minX" : 399, "maxX" : 471, "minY" : 518, "maxY" : 567, "prop" : { "x" : 427, "y" : 535, "width" : 43, "height" : 32 }, "textPosition" : { "x" : 432, "y" : 540 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 465, "y" : 540 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 465, "y" : 540 } } }, "connectors" : [ { "edgeId" : 86036, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 424, "y" : 536 }, "to" : { "x" : 399, "y" : 518 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 416, "y" : 535 }, "b" : { "x" : 424, "y" : 536 }, "c" : { "x" : 421, "y" : 529 }, "type" : "ARROW", "centre" : { "x" : 421, "y" : 529 } } } ] }, { "id" : 86038, "reactomeId" : 113521, "displayName" : "H2O", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 477, "y" : 480 }, "minX" : 418, "maxX" : 500, "minY" : 457, "maxY" : 496, "prop" : { "x" : 455, "y" : 465, "width" : 44, "height" : 31 }, "textPosition" : { "x" : 460, "y" : 470 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 494, "y" : 470 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 494, "y" : 470 } } }, "connectors" : [ { "edgeId" : 86036, "type" : "INPUT", "segments" : [ { "from" : { "x" : 452, "y" : 471 }, "to" : { "x" : 418, "y" : 457 } } ], "stoichiometry" : { "value" : 1 } } ], "trivial" : true }, { "id" : 86040, "reactomeId" : 113548, "displayName" : "Pi", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 398, "y" : 570 }, "minX" : 380, "maxX" : 417, "minY" : 518, "maxY" : 587, "prop" : { "x" : 380, "y" : 554, "width" : 36, "height" : 33 }, "textPosition" : { "x" : 388, "y" : 560 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 411, "y" : 559 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 411, "y" : 559 } } }, "connectors" : [ { "edgeId" : 86036, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 398, "y" : 551 }, "to" : { "x" : 399, "y" : 518 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 394, "y" : 544 }, "b" : { "x" : 398, "y" : 551 }, "c" : { "x" : 402, "y" : 544 }, "type" : "ARROW", "centre" : { "x" : 402, "y" : 544 } } } ] }, { "id" : 86043, "reactomeId" : 10094243, "displayName" : "LONP1:substrate protein (mitochondrial inner membrane)", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 167, "y" : 395 }, "minX" : 66, "maxX" : 274, "minY" : 367, "maxY" : 492, "prop" : { "x" : 66, "y" : 373, "width" : 202, "height" : 45 }, "textPosition" : { "x" : 84, "y" : 369 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 268, "y" : 373 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 268, "y" : 373 } } }, "connectors" : [ { "edgeId" : 86041, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 86044, "type" : "INPUT", "segments" : [ { "from" : { "x" : 165, "y" : 421 }, "to" : { "x" : 162, "y" : 474 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 86044, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 168, "y" : 421 }, "to" : { "x" : 172, "y" : 484 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 172, "y" : 488 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 172, "y" : 488 } } } ] }, { "id" : 86042, "reactomeId" : 10094241, "displayName" : "Substrate of LONP1 (mitochondrial inner membrane)", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 126, "y" : 239 }, "minX" : 26, "maxX" : 226, "minY" : 219, "maxY" : 316, "prop" : { "x" : 26, "y" : 219, "width" : 200, "height" : 41 }, "textPosition" : { "x" : 57, "y" : 215 }, "connectors" : [ { "edgeId" : 86041, "type" : "INPUT", "segments" : [ { "from" : { "x" : 136, "y" : 266 }, "to" : { "x" : 164, "y" : 316 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 86045, "reactomeId" : 113521, "displayName" : "H2O", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 111, "y" : 481 }, "minX" : 89, "maxX" : 162, "minY" : 465, "maxY" : 497, "prop" : { "x" : 89, "y" : 466, "width" : 44, "height" : 31 }, "textPosition" : { "x" : 94, "y" : 471 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 128, "y" : 471 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 128, "y" : 471 } } }, "connectors" : [ { "edgeId" : 86044, "type" : "INPUT", "segments" : [ { "from" : { "x" : 136, "y" : 477 }, "to" : { "x" : 162, "y" : 474 } } ], "stoichiometry" : { "value" : 1 } } ], "trivial" : true }, { "id" : 86047, "reactomeId" : 113581, "displayName" : "ADP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 120, "y" : 549 }, "minX" : 99, "maxX" : 174, "minY" : 522, "maxY" : 565, "prop" : { "x" : 99, "y" : 534, "width" : 42, "height" : 31 }, "textPosition" : { "x" : 103, "y" : 539 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 136, "y" : 539 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 136, "y" : 539 } } }, "connectors" : [ { "edgeId" : 86044, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 144, "y" : 538 }, "to" : { "x" : 174, "y" : 522 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 148, "y" : 531 }, "b" : { "x" : 144, "y" : 538 }, "c" : { "x" : 152, "y" : 538 }, "type" : "ARROW", "centre" : { "x" : 152, "y" : 538 } } } ] }, { "id" : 86046, "reactomeId" : 113593, "displayName" : "ATP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 113, "y" : 443 }, "minX" : 93, "maxX" : 162, "minY" : 427, "maxY" : 474, "prop" : { "x" : 93, "y" : 428, "width" : 41, "height" : 31 }, "textPosition" : { "x" : 98, "y" : 433 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 129, "y" : 433 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 129, "y" : 433 } } }, "connectors" : [ { "edgeId" : 86044, "type" : "INPUT", "segments" : [ { "from" : { "x" : 137, "y" : 455 }, "to" : { "x" : 162, "y" : 474 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 86048, "reactomeId" : 113548, "displayName" : "Pi", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 169, "y" : 571 }, "minX" : 151, "maxX" : 188, "minY" : 522, "maxY" : 588, "prop" : { "x" : 151, "y" : 555, "width" : 36, "height" : 33 }, "textPosition" : { "x" : 159, "y" : 561 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 182, "y" : 560 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 182, "y" : 560 } } }, "connectors" : [ { "edgeId" : 86044, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 170, "y" : 552 }, "to" : { "x" : 174, "y" : 522 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 167, "y" : 545 }, "b" : { "x" : 170, "y" : 552 }, "c" : { "x" : 175, "y" : 546 }, "type" : "ARROW", "centre" : { "x" : 175, "y" : 546 } } } ] }, { "id" : 86051, "reactomeId" : 10094258, "displayName" : "CLPXP", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 758, "y" : 653 }, "minX" : 658, "maxX" : 793, "minY" : 634, "maxY" : 850, "prop" : { "x" : 729, "y" : 640, "width" : 58, "height" : 27 }, "textPosition" : { "x" : 735, "y" : 646 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 787, "y" : 640 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 787, "y" : 640 } } }, "connectors" : [ { "edgeId" : 86049, "type" : "INPUT", "segments" : [ { "from" : { "x" : 726, "y" : 664 }, "to" : { "x" : 665, "y" : 690 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 86053, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 757, "y" : 670 }, "to" : { "x" : 755, "y" : 850 } }, { "from" : { "x" : 755, "y" : 850 }, "to" : { "x" : 658, "y" : 847 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 761, "y" : 677 }, "b" : { "x" : 757, "y" : 670 }, "c" : { "x" : 753, "y" : 677 }, "type" : "ARROW", "centre" : { "x" : 753, "y" : 677 } } } ] }, { "id" : 86050, "reactomeId" : 10094278, "displayName" : "Substrate of CLPXP (mitrochondrial matrix)", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 548, "y" : 655 }, "minX" : 461, "maxX" : 665, "minY" : 634, "maxY" : 690, "prop" : { "x" : 461, "y" : 634, "width" : 175, "height" : 43 }, "textPosition" : { "x" : 473, "y" : 638 }, "connectors" : [ { "edgeId" : 86049, "type" : "INPUT", "segments" : [ { "from" : { "x" : 619, "y" : 683 }, "to" : { "x" : 665, "y" : 690 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 86052, "reactomeId" : 10094280, "displayName" : "CLPXP:substrate protein (mitochondrial matrix)", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 663, "y" : 756 }, "minX" : 577, "maxX" : 756, "minY" : 731, "maxY" : 818, "prop" : { "x" : 577, "y" : 737, "width" : 173, "height" : 39 }, "textPosition" : { "x" : 582, "y" : 741 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 750, "y" : 737 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 750, "y" : 737 } } }, "connectors" : [ { "edgeId" : 86049, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 86053, "type" : "INPUT", "segments" : [ { "from" : { "x" : 656, "y" : 779 }, "to" : { "x" : 645, "y" : 808 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 86053, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 661, "y" : 779 }, "to" : { "x" : 659, "y" : 810 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 659, "y" : 814 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 659, "y" : 814 } } } ] }, { "id" : 86055, "reactomeId" : 113593, "displayName" : "ATP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 581, "y" : 799 }, "minX" : 561, "maxX" : 645, "minY" : 783, "maxY" : 815, "prop" : { "x" : 561, "y" : 784, "width" : 41, "height" : 31 }, "textPosition" : { "x" : 566, "y" : 789 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 597, "y" : 789 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 597, "y" : 789 } } }, "connectors" : [ { "edgeId" : 86053, "type" : "INPUT", "segments" : [ { "from" : { "x" : 605, "y" : 801 }, "to" : { "x" : 645, "y" : 808 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 86054, "reactomeId" : 113521, "displayName" : "H2O", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 580, "y" : 834 }, "minX" : 558, "maxX" : 645, "minY" : 808, "maxY" : 850, "prop" : { "x" : 558, "y" : 819, "width" : 44, "height" : 31 }, "textPosition" : { "x" : 563, "y" : 824 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 597, "y" : 824 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 597, "y" : 824 } } }, "connectors" : [ { "edgeId" : 86053, "type" : "INPUT", "segments" : [ { "from" : { "x" : 605, "y" : 825 }, "to" : { "x" : 645, "y" : 808 } } ], "stoichiometry" : { "value" : 1 } } ], "trivial" : true }, { "id" : 86057, "reactomeId" : 113548, "displayName" : "Pi", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 613, "y" : 889 }, "minX" : 595, "maxX" : 658, "minY" : 847, "maxY" : 906, "prop" : { "x" : 595, "y" : 873, "width" : 36, "height" : 33 }, "textPosition" : { "x" : 603, "y" : 879 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 626, "y" : 878 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 626, "y" : 878 } } }, "connectors" : [ { "edgeId" : 86053, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 630, "y" : 870 }, "to" : { "x" : 658, "y" : 847 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 633, "y" : 863 }, "b" : { "x" : 630, "y" : 870 }, "c" : { "x" : 638, "y" : 869 }, "type" : "ARROW", "centre" : { "x" : 638, "y" : 869 } } } ] }, { "id" : 86056, "reactomeId" : 113581, "displayName" : "ADP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 663, "y" : 891 }, "minX" : 642, "maxX" : 685, "minY" : 847, "maxY" : 907, "prop" : { "x" : 642, "y" : 876, "width" : 42, "height" : 31 }, "textPosition" : { "x" : 646, "y" : 881 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 679, "y" : 881 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 679, "y" : 881 } } }, "connectors" : [ { "edgeId" : 86053, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 661, "y" : 873 }, "to" : { "x" : 658, "y" : 847 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 656, "y" : 867 }, "b" : { "x" : 661, "y" : 873 }, "c" : { "x" : 664, "y" : 866 }, "type" : "ARROW", "centre" : { "x" : 664, "y" : 866 } } } ] }, { "id" : 86059, "reactomeId" : 10094325, "displayName" : "AFG3L2:Zn2+ hexamer", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 991, "y" : 156 }, "minX" : 790, "maxX" : 1078, "minY" : 138, "maxY" : 384, "prop" : { "x" : 910, "y" : 144, "width" : 162, "height" : 24 }, "textPosition" : { "x" : 915, "y" : 147 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1072, "y" : 144 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1072, "y" : 144 } } }, "connectors" : [ { "edgeId" : 86058, "type" : "INPUT", "segments" : [ { "from" : { "x" : 932, "y" : 171 }, "to" : { "x" : 824, "y" : 190 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 86062, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 958, "y" : 171 }, "to" : { "x" : 885, "y" : 195 } }, { "from" : { "x" : 885, "y" : 195 }, "to" : { "x" : 885, "y" : 362 } }, { "from" : { "x" : 885, "y" : 362 }, "to" : { "x" : 790, "y" : 366 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 953, "y" : 177 }, "b" : { "x" : 958, "y" : 171 }, "c" : { "x" : 950, "y" : 169 }, "type" : "ARROW", "centre" : { "x" : 950, "y" : 169 } } }, { "edgeId" : 86067, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1007, "y" : 171 }, "to" : { "x" : 1045, "y" : 195 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 86070, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 982, "y" : 171 }, "to" : { "x" : 921, "y" : 260 } }, { "from" : { "x" : 921, "y" : 260 }, "to" : { "x" : 925, "y" : 384 } }, { "from" : { "x" : 925, "y" : 384 }, "to" : { "x" : 1045, "y" : 381 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 981, "y" : 179 }, "b" : { "x" : 982, "y" : 171 }, "c" : { "x" : 975, "y" : 174 }, "type" : "ARROW", "centre" : { "x" : 975, "y" : 174 } } } ] }, { "id" : 86061, "reactomeId" : 10094363, "displayName" : "AFG3L2:substrate protein (mitochondrial matrix)", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 787, "y" : 278 }, "minX" : 700, "maxX" : 880, "minY" : 253, "maxY" : 335, "prop" : { "x" : 700, "y" : 259, "width" : 174, "height" : 38 }, "textPosition" : { "x" : 701, "y" : 262 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 874, "y" : 259 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 874, "y" : 259 } } }, "connectors" : [ { "edgeId" : 86058, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 86062, "type" : "INPUT", "segments" : [ { "from" : { "x" : 781, "y" : 300 }, "to" : { "x" : 790, "y" : 319 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 86062, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 788, "y" : 300 }, "to" : { "x" : 790, "y" : 327 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 790, "y" : 331 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 790, "y" : 331 } } } ] }, { "id" : 86060, "reactomeId" : 10094361, "displayName" : "Substrate of AFG3L2 (mitochondrial matrix)", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 714, "y" : 155 }, "minX" : 635, "maxX" : 824, "minY" : 137, "maxY" : 190, "prop" : { "x" : 635, "y" : 137, "width" : 158, "height" : 37 }, "textPosition" : { "x" : 641, "y" : 138 }, "connectors" : [ { "edgeId" : 86058, "type" : "INPUT", "segments" : [ { "from" : { "x" : 772, "y" : 180 }, "to" : { "x" : 824, "y" : 190 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 86063, "reactomeId" : 113521, "displayName" : "H2O", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 714, "y" : 357 }, "minX" : 693, "maxX" : 790, "minY" : 319, "maxY" : 373, "prop" : { "x" : 693, "y" : 342, "width" : 43, "height" : 31 }, "textPosition" : { "x" : 697, "y" : 347 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 731, "y" : 347 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 731, "y" : 347 } } }, "connectors" : [ { "edgeId" : 86062, "type" : "INPUT", "segments" : [ { "from" : { "x" : 739, "y" : 346 }, "to" : { "x" : 790, "y" : 319 } } ], "stoichiometry" : { "value" : 1 } } ], "trivial" : true }, { "id" : 86065, "reactomeId" : 113581, "displayName" : "ADP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 801, "y" : 410 }, "minX" : 780, "maxX" : 823, "minY" : 366, "maxY" : 426, "prop" : { "x" : 780, "y" : 395, "width" : 42, "height" : 31 }, "textPosition" : { "x" : 784, "y" : 400 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 817, "y" : 400 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 817, "y" : 400 } } }, "connectors" : [ { "edgeId" : 86062, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 797, "y" : 392 }, "to" : { "x" : 790, "y" : 366 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 791, "y" : 386 }, "b" : { "x" : 797, "y" : 392 }, "c" : { "x" : 799, "y" : 384 }, "type" : "ARROW", "centre" : { "x" : 799, "y" : 384 } } } ] }, { "id" : 86064, "reactomeId" : 113593, "displayName" : "ATP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 716, "y" : 320 }, "minX" : 697, "maxX" : 790, "minY" : 304, "maxY" : 336, "prop" : { "x" : 697, "y" : 305, "width" : 39, "height" : 31 }, "textPosition" : { "x" : 701, "y" : 310 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 731, "y" : 310 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 731, "y" : 310 } } }, "connectors" : [ { "edgeId" : 86062, "type" : "INPUT", "segments" : [ { "from" : { "x" : 739, "y" : 319 }, "to" : { "x" : 790, "y" : 319 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 86066, "reactomeId" : 113548, "displayName" : "Pi", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 752, "y" : 402 }, "minX" : 734, "maxX" : 790, "minY" : 366, "maxY" : 419, "prop" : { "x" : 734, "y" : 386, "width" : 36, "height" : 33 }, "textPosition" : { "x" : 742, "y" : 392 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 765, "y" : 391 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 765, "y" : 391 } } }, "connectors" : [ { "edgeId" : 86062, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 769, "y" : 383 }, "to" : { "x" : 790, "y" : 366 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 772, "y" : 376 }, "b" : { "x" : 769, "y" : 383 }, "c" : { "x" : 777, "y" : 382 }, "type" : "ARROW", "centre" : { "x" : 777, "y" : 382 } } } ] }, { "id" : 86069, "reactomeId" : 10094329, "displayName" : "AFG3L2:substrate protein (mitochondrial inner membrane)", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 1047, "y" : 269 }, "minX" : 943, "maxX" : 1158, "minY" : 241, "maxY" : 356, "prop" : { "x" : 943, "y" : 247, "width" : 209, "height" : 44 }, "textPosition" : { "x" : 961, "y" : 242 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1152, "y" : 247 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1152, "y" : 247 } } }, "connectors" : [ { "edgeId" : 86067, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 86070, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1044, "y" : 294 }, "to" : { "x" : 1040, "y" : 328 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 86070, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 1046, "y" : 294 }, "to" : { "x" : 1045, "y" : 348 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 1045, "y" : 352 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1045, "y" : 352 } } } ] }, { "id" : 86068, "reactomeId" : 10094327, "displayName" : "Substrate of AFG3L2 (mitochondrial inner membrane)", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 1078, "y" : 106 }, "minX" : 975, "maxX" : 1181, "minY" : 87, "maxY" : 195, "prop" : { "x" : 975, "y" : 87, "width" : 206, "height" : 38 }, "textPosition" : { "x" : 1008, "y" : 82 }, "connectors" : [ { "edgeId" : 86067, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1078, "y" : 131 }, "to" : { "x" : 1078, "y" : 180 } }, { "from" : { "x" : 1078, "y" : 180 }, "to" : { "x" : 1045, "y" : 195 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 86071, "reactomeId" : 113521, "displayName" : "H2O", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 967, "y" : 348 }, "minX" : 946, "maxX" : 1040, "minY" : 328, "maxY" : 364, "prop" : { "x" : 946, "y" : 333, "width" : 43, "height" : 31 }, "textPosition" : { "x" : 950, "y" : 338 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 984, "y" : 338 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 984, "y" : 338 } } }, "connectors" : [ { "edgeId" : 86070, "type" : "INPUT", "segments" : [ { "from" : { "x" : 992, "y" : 342 }, "to" : { "x" : 1040, "y" : 328 } } ], "stoichiometry" : { "value" : 1 } } ], "trivial" : true }, { "id" : 86073, "reactomeId" : 113581, "displayName" : "ADP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1003, "y" : 436 }, "minX" : 982, "maxX" : 1045, "minY" : 381, "maxY" : 452, "prop" : { "x" : 982, "y" : 421, "width" : 42, "height" : 31 }, "textPosition" : { "x" : 986, "y" : 426 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1019, "y" : 426 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1019, "y" : 426 } } }, "connectors" : [ { "edgeId" : 86070, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 1014, "y" : 418 }, "to" : { "x" : 1045, "y" : 381 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1015, "y" : 410 }, "b" : { "x" : 1014, "y" : 418 }, "c" : { "x" : 1022, "y" : 415 }, "type" : "ARROW", "centre" : { "x" : 1022, "y" : 415 } } } ] }, { "id" : 86072, "reactomeId" : 113593, "displayName" : "ATP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 966, "y" : 312 }, "minX" : 947, "maxX" : 1040, "minY" : 296, "maxY" : 328, "prop" : { "x" : 947, "y" : 297, "width" : 39, "height" : 31 }, "textPosition" : { "x" : 951, "y" : 302 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 981, "y" : 302 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 981, "y" : 302 } } }, "connectors" : [ { "edgeId" : 86070, "type" : "INPUT", "segments" : [ { "from" : { "x" : 989, "y" : 316 }, "to" : { "x" : 1040, "y" : 328 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 86074, "reactomeId" : 113548, "displayName" : "Pi", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 955, "y" : 429 }, "minX" : 937, "maxX" : 1045, "minY" : 381, "maxY" : 446, "prop" : { "x" : 937, "y" : 413, "width" : 36, "height" : 33 }, "textPosition" : { "x" : 945, "y" : 419 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 968, "y" : 418 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 968, "y" : 418 } } }, "connectors" : [ { "edgeId" : 86070, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 976, "y" : 419 }, "to" : { "x" : 1045, "y" : 381 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 980, "y" : 412 }, "b" : { "x" : 976, "y" : 419 }, "c" : { "x" : 984, "y" : 419 }, "type" : "ARROW", "centre" : { "x" : 984, "y" : 419 } } } ] }, { "id" : 86077, "reactomeId" : 10094335, "displayName" : "AFG3L2:Zn2+:SPG7:Zn2+ heterohexamer", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 101, "y" : 712 }, "minX" : 41, "maxX" : 190, "minY" : 678, "maxY" : 960, "prop" : { "x" : 41, "y" : 684, "width" : 120, "height" : 56 }, "textPosition" : { "x" : 49, "y" : 691 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 161, "y" : 684 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 161, "y" : 684 } } }, "connectors" : [ { "edgeId" : 86075, "type" : "INPUT", "segments" : [ { "from" : { "x" : 99, "y" : 743 }, "to" : { "x" : 99, "y" : 762 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 86079, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 144, "y" : 743 }, "to" : { "x" : 187, "y" : 767 } }, { "from" : { "x" : 187, "y" : 767 }, "to" : { "x" : 190, "y" : 960 } }, { "from" : { "x" : 190, "y" : 960 }, "to" : { "x" : 98, "y" : 960 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 152, "y" : 743 }, "b" : { "x" : 144, "y" : 743 }, "c" : { "x" : 148, "y" : 750 }, "type" : "ARROW", "centre" : { "x" : 148, "y" : 750 } } } ] }, { "id" : 86076, "reactomeId" : 10082370, "displayName" : "Smdt1", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 87, "y" : 639 }, "minX" : 20, "maxX" : 123, "minY" : 620, "maxY" : 762, "prop" : { "x" : 58, "y" : 626, "width" : 59, "height" : 27 }, "textPosition" : { "x" : 63, "y" : 629 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 117, "y" : 626 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 117, "y" : 626 } } }, "connectors" : [ { "edgeId" : 86075, "type" : "INPUT", "segments" : [ { "from" : { "x" : 64, "y" : 656 }, "to" : { "x" : 20, "y" : 679 } }, { "from" : { "x" : 20, "y" : 679 }, "to" : { "x" : 21, "y" : 756 } }, { "from" : { "x" : 21, "y" : 756 }, "to" : { "x" : 99, "y" : 762 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 86078, "reactomeId" : 10094337, "displayName" : "AFG3L2:SPG7:SMDT1", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 100, "y" : 829 }, "minX" : 44, "maxX" : 163, "minY" : 804, "maxY" : 926, "prop" : { "x" : 44, "y" : 810, "width" : 113, "height" : 38 }, "textPosition" : { "x" : 53, "y" : 813 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 157, "y" : 810 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 157, "y" : 810 } } }, "connectors" : [ { "edgeId" : 86075, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 86079, "type" : "INPUT", "segments" : [ { "from" : { "x" : 99, "y" : 851 }, "to" : { "x" : 97, "y" : 896 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 86079, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 100, "y" : 851 }, "to" : { "x" : 100, "y" : 918 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 100, "y" : 922 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 100, "y" : 922 } } } ] }, { "id" : 86081, "reactomeId" : 113593, "displayName" : "ATP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 152, "y" : 875 }, "minX" : 97, "maxX" : 173, "minY" : 859, "maxY" : 896, "prop" : { "x" : 133, "y" : 860, "width" : 39, "height" : 31 }, "textPosition" : { "x" : 137, "y" : 865 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 167, "y" : 865 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 167, "y" : 865 } } }, "connectors" : [ { "edgeId" : 86079, "type" : "INPUT", "segments" : [ { "from" : { "x" : 130, "y" : 882 }, "to" : { "x" : 97, "y" : 896 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 86080, "reactomeId" : 113521, "displayName" : "H2O", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 157, "y" : 910 }, "minX" : 97, "maxX" : 180, "minY" : 894, "maxY" : 926, "prop" : { "x" : 136, "y" : 895, "width" : 43, "height" : 31 }, "textPosition" : { "x" : 140, "y" : 900 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 174, "y" : 900 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 174, "y" : 900 } } }, "connectors" : [ { "edgeId" : 86079, "type" : "INPUT", "segments" : [ { "from" : { "x" : 133, "y" : 904 }, "to" : { "x" : 97, "y" : 896 } } ], "stoichiometry" : { "value" : 1 } } ], "trivial" : true }, { "id" : 86083, "reactomeId" : 113548, "displayName" : "Pi", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 148, "y" : 995 }, "minX" : 98, "maxX" : 167, "minY" : 960, "maxY" : 1012, "prop" : { "x" : 130, "y" : 979, "width" : 36, "height" : 33 }, "textPosition" : { "x" : 138, "y" : 985 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 161, "y" : 984 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 161, "y" : 984 } } }, "connectors" : [ { "edgeId" : 86079, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 127, "y" : 982 }, "to" : { "x" : 98, "y" : 960 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 119, "y" : 981 }, "b" : { "x" : 127, "y" : 982 }, "c" : { "x" : 124, "y" : 975 }, "type" : "ARROW", "centre" : { "x" : 124, "y" : 975 } } } ] }, { "id" : 86082, "reactomeId" : 113581, "displayName" : "ADP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 124, "y" : 1029 }, "minX" : 98, "maxX" : 146, "minY" : 960, "maxY" : 1045, "prop" : { "x" : 103, "y" : 1014, "width" : 42, "height" : 31 }, "textPosition" : { "x" : 107, "y" : 1019 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 140, "y" : 1019 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 140, "y" : 1019 } } }, "connectors" : [ { "edgeId" : 86079, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 118, "y" : 1011 }, "to" : { "x" : 98, "y" : 960 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 112, "y" : 1006 }, "b" : { "x" : 118, "y" : 1011 }, "c" : { "x" : 119, "y" : 1003 }, "type" : "ARROW", "centre" : { "x" : 119, "y" : 1003 } } } ] }, { "id" : 86085, "reactomeId" : 10094352, "displayName" : "HTRA2 trimer", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 524, "y" : 1321 }, "minX" : 229, "maxX" : 756, "minY" : 1283, "maxY" : 1335, "prop" : { "x" : 468, "y" : 1307, "width" : 113, "height" : 28 }, "textPosition" : { "x" : 480, "y" : 1314 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 581, "y" : 1307 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 581, "y" : 1307 } } }, "connectors" : [ { "edgeId" : 86084, "type" : "INPUT", "segments" : [ { "from" : { "x" : 509, "y" : 1304 }, "to" : { "x" : 484, "y" : 1283 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 86088, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 465, "y" : 1322 }, "to" : { "x" : 229, "y" : 1327 } }, { "from" : { "x" : 229, "y" : 1327 }, "to" : { "x" : 229, "y" : 1284 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 458, "y" : 1326 }, "b" : { "x" : 465, "y" : 1322 }, "c" : { "x" : 458, "y" : 1318 }, "type" : "ARROW", "centre" : { "x" : 458, "y" : 1318 } } }, { "edgeId" : 86097, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 584, "y" : 1321 }, "to" : { "x" : 748, "y" : 1322 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 752, "y" : 1322 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 752, "y" : 1322 } } } ] }, { "id" : 86087, "reactomeId" : 10094357, "displayName" : "HTRA2:NDUFA13", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 372, "y" : 1286 }, "minX" : 264, "maxX" : 441, "minY" : 1266, "maxY" : 1301, "prop" : { "x" : 309, "y" : 1272, "width" : 126, "height" : 29 }, "textPosition" : { "x" : 317, "y" : 1280 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 435, "y" : 1272 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 435, "y" : 1272 } } }, "connectors" : [ { "edgeId" : 86084, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 86088, "type" : "INPUT", "segments" : [ { "from" : { "x" : 306, "y" : 1272 }, "to" : { "x" : 292, "y" : 1269 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 86088, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 306, "y" : 1284 }, "to" : { "x" : 272, "y" : 1283 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 268, "y" : 1283 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 268, "y" : 1283 } } } ] }, { "id" : 86086, "reactomeId" : 9995826, "displayName" : "Ndufa13", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 559, "y" : 1285 }, "minX" : 484, "maxX" : 603, "minY" : 1265, "maxY" : 1300, "prop" : { "x" : 522, "y" : 1271, "width" : 75, "height" : 29 }, "textPosition" : { "x" : 529, "y" : 1275 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 597, "y" : 1271 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 597, "y" : 1271 } } }, "connectors" : [ { "edgeId" : 86084, "type" : "INPUT", "segments" : [ { "from" : { "x" : 519, "y" : 1284 }, "to" : { "x" : 484, "y" : 1283 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 86089, "reactomeId" : 189422, "displayName" : "H2O", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 346, "y" : 1241 }, "minX" : 292, "maxX" : 370, "minY" : 1225, "maxY" : 1269, "prop" : { "x" : 323, "y" : 1226, "width" : 46, "height" : 31 }, "textPosition" : { "x" : 329, "y" : 1231 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 364, "y" : 1231 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 364, "y" : 1231 } } }, "connectors" : [ { "edgeId" : 86088, "type" : "INPUT", "segments" : [ { "from" : { "x" : 320, "y" : 1252 }, "to" : { "x" : 292, "y" : 1269 } } ], "stoichiometry" : { "value" : 1 } } ], "trivial" : true }, { "id" : 86091, "reactomeId" : 10094378, "displayName" : "Ndufa13", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 97, "y" : 1131 }, "minX" : 40, "maxX" : 229, "minY" : 1112, "maxY" : 1284, "prop" : { "x" : 40, "y" : 1118, "width" : 115, "height" : 27 }, "textPosition" : { "x" : 67, "y" : 1121 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 155, "y" : 1118 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 155, "y" : 1118 } } }, "connectors" : [ { "edgeId" : 86088, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 158, "y" : 1132 }, "to" : { "x" : 188, "y" : 1134 } }, { "from" : { "x" : 188, "y" : 1134 }, "to" : { "x" : 229, "y" : 1284 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 165, "y" : 1128 }, "b" : { "x" : 158, "y" : 1132 }, "c" : { "x" : 165, "y" : 1136 }, "type" : "ARROW", "centre" : { "x" : 165, "y" : 1136 } } } ] }, { "id" : 86090, "reactomeId" : 10094370, "displayName" : "Ndufa13", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 92, "y" : 1102 }, "minX" : 24, "maxX" : 229, "minY" : 1082, "maxY" : 1284, "prop" : { "x" : 24, "y" : 1088, "width" : 136, "height" : 28 }, "textPosition" : { "x" : 61, "y" : 1091 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 160, "y" : 1088 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 160, "y" : 1088 } } }, "connectors" : [ { "edgeId" : 86088, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 163, "y" : 1100 }, "to" : { "x" : 192, "y" : 1100 } }, { "from" : { "x" : 192, "y" : 1100 }, "to" : { "x" : 229, "y" : 1284 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 170, "y" : 1096 }, "b" : { "x" : 163, "y" : 1100 }, "c" : { "x" : 170, "y" : 1104 }, "type" : "ARROW", "centre" : { "x" : 170, "y" : 1104 } } } ] }, { "id" : 86093, "reactomeId" : 10094374, "displayName" : "Ndufa13", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 99, "y" : 1190 }, "minX" : 41, "maxX" : 229, "minY" : 1169, "maxY" : 1284, "prop" : { "x" : 41, "y" : 1175, "width" : 117, "height" : 30 }, "textPosition" : { "x" : 69, "y" : 1179 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 158, "y" : 1175 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 158, "y" : 1175 } } }, "connectors" : [ { "edgeId" : 86088, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 161, "y" : 1189 }, "to" : { "x" : 188, "y" : 1189 } }, { "from" : { "x" : 188, "y" : 1189 }, "to" : { "x" : 229, "y" : 1284 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 168, "y" : 1185 }, "b" : { "x" : 161, "y" : 1189 }, "c" : { "x" : 168, "y" : 1193 }, "type" : "ARROW", "centre" : { "x" : 168, "y" : 1193 } } } ] }, { "id" : 86092, "reactomeId" : 10094380, "displayName" : "Ndufa13", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 98, "y" : 1159 }, "minX" : 43, "maxX" : 229, "minY" : 1139, "maxY" : 1284, "prop" : { "x" : 43, "y" : 1145, "width" : 111, "height" : 29 }, "textPosition" : { "x" : 68, "y" : 1149 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 154, "y" : 1145 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 154, "y" : 1145 } } }, "connectors" : [ { "edgeId" : 86088, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 157, "y" : 1160 }, "to" : { "x" : 187, "y" : 1162 } }, { "from" : { "x" : 187, "y" : 1162 }, "to" : { "x" : 229, "y" : 1284 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 164, "y" : 1156 }, "b" : { "x" : 157, "y" : 1160 }, "c" : { "x" : 164, "y" : 1164 }, "type" : "ARROW", "centre" : { "x" : 164, "y" : 1164 } } } ] }, { "id" : 86095, "reactomeId" : 10094368, "displayName" : "Ndufa13", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 99, "y" : 1256 }, "minX" : 37, "maxX" : 229, "minY" : 1235, "maxY" : 1284, "prop" : { "x" : 37, "y" : 1241, "width" : 124, "height" : 30 }, "textPosition" : { "x" : 68, "y" : 1245 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 161, "y" : 1241 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 161, "y" : 1241 } } }, "connectors" : [ { "edgeId" : 86088, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 164, "y" : 1254 }, "to" : { "x" : 192, "y" : 1254 } }, { "from" : { "x" : 192, "y" : 1254 }, "to" : { "x" : 229, "y" : 1284 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 171, "y" : 1250 }, "b" : { "x" : 164, "y" : 1254 }, "c" : { "x" : 171, "y" : 1258 }, "type" : "ARROW", "centre" : { "x" : 171, "y" : 1258 } } } ] }, { "id" : 86094, "reactomeId" : 10094376, "displayName" : "Ndufa13", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 97, "y" : 1224 }, "minX" : 38, "maxX" : 229, "minY" : 1204, "maxY" : 1284, "prop" : { "x" : 38, "y" : 1210, "width" : 119, "height" : 28 }, "textPosition" : { "x" : 67, "y" : 1213 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 157, "y" : 1210 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 157, "y" : 1210 } } }, "connectors" : [ { "edgeId" : 86088, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 160, "y" : 1222 }, "to" : { "x" : 190, "y" : 1221 } }, { "from" : { "x" : 190, "y" : 1221 }, "to" : { "x" : 229, "y" : 1284 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 167, "y" : 1218 }, "b" : { "x" : 160, "y" : 1222 }, "c" : { "x" : 167, "y" : 1226 }, "type" : "ARROW", "centre" : { "x" : 167, "y" : 1226 } } } ] }, { "id" : 86096, "reactomeId" : 10094372, "displayName" : "Ndufa13", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 102, "y" : 1289 }, "minX" : 51, "maxX" : 229, "minY" : 1268, "maxY" : 1304, "prop" : { "x" : 51, "y" : 1274, "width" : 102, "height" : 30 }, "textPosition" : { "x" : 71, "y" : 1278 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 153, "y" : 1274 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 153, "y" : 1274 } } }, "connectors" : [ { "edgeId" : 86088, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 156, "y" : 1286 }, "to" : { "x" : 229, "y" : 1284 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 163, "y" : 1282 }, "b" : { "x" : 156, "y" : 1286 }, "c" : { "x" : 163, "y" : 1290 }, "type" : "ARROW", "centre" : { "x" : 163, "y" : 1290 } } } ] }, { "id" : 86099, "reactomeId" : 10094344, "displayName" : "APP", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 705, "y" : 1283 }, "minX" : 678, "maxX" : 764, "minY" : 1263, "maxY" : 1298, "prop" : { "x" : 678, "y" : 1269, "width" : 54, "height" : 28 }, "textPosition" : { "x" : 689, "y" : 1272 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 732, "y" : 1269 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 732, "y" : 1269 } } }, "connectors" : [ { "edgeId" : 86097, "type" : "INPUT", "segments" : [ { "from" : { "x" : 735, "y" : 1289 }, "to" : { "x" : 764, "y" : 1298 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 86098, "reactomeId" : 189422, "displayName" : "H2O", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 837, "y" : 1312 }, "minX" : 764, "maxX" : 861, "minY" : 1296, "maxY" : 1328, "prop" : { "x" : 815, "y" : 1297, "width" : 45, "height" : 31 }, "textPosition" : { "x" : 820, "y" : 1302 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 855, "y" : 1302 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 855, "y" : 1302 } } }, "connectors" : [ { "edgeId" : 86097, "type" : "INPUT", "segments" : [ { "from" : { "x" : 812, "y" : 1307 }, "to" : { "x" : 764, "y" : 1298 } } ], "stoichiometry" : { "value" : 1 } } ], "trivial" : true }, { "id" : 86100, "reactomeId" : 10094346, "displayName" : "APP (535-695)", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 763, "y" : 1394 }, "minX" : 715, "maxX" : 818, "minY" : 1370, "maxY" : 1412, "prop" : { "x" : 715, "y" : 1376, "width" : 97, "height" : 36 }, "textPosition" : { "x" : 729, "y" : 1376 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 812, "y" : 1376 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 812, "y" : 1376 } } }, "connectors" : [ { "edgeId" : 86097, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] } ], "edges" : [ { "id" : 86049, "reactomeId" : 10094282, "displayName" : "CLPXP binds mitochondrial matrix proteins", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 664, "y" : 711 }, "minX" : 658, "maxX" : 670, "minY" : 690, "maxY" : 734, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 665, "y" : 690 }, "to" : { "x" : 664, "y" : 711 } }, { "from" : { "x" : 664, "y" : 711 }, "to" : { "x" : 663, "y" : 734 } } ], "endShape" : { "a" : { "x" : 659, "y" : 727 }, "b" : { "x" : 663, "y" : 734 }, "c" : { "x" : 667, "y" : 727 }, "type" : "ARROW", "centre" : { "x" : 667, "y" : 727 } }, "reactionShape" : { "c" : { "x" : 664, "y" : 711 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 664, "y" : 711 } }, "inputs" : [ { "id" : 86050, "points" : [ { "x" : 619, "y" : 683 } ] }, { "id" : 86051, "points" : [ { "x" : 726, "y" : 664 } ] } ], "outputs" : [ { "id" : 86052 } ] }, { "id" : 86053, "reactomeId" : 10094318, "displayName" : "CLPXP degrades mitochondrial matrix proteins", "schemaClass" : "BlackBoxEvent", "renderableClass" : "Reaction", "position" : { "x" : 658, "y" : 826 }, "minX" : 645, "maxX" : 664, "minY" : 808, "maxY" : 847, "reactionType" : "omitted", "segments" : [ { "from" : { "x" : 645, "y" : 808 }, "to" : { "x" : 658, "y" : 826 } }, { "from" : { "x" : 658, "y" : 826 }, "to" : { "x" : 658, "y" : 847 } } ], "reactionShape" : { "a" : { "x" : 652, "y" : 820 }, "b" : { "x" : 664, "y" : 832 }, "s" : "\\\\", "type" : "BOX", "empty" : true, "centre" : { "x" : 658, "y" : 826 } }, "inputs" : [ { "id" : 86054, "points" : [ { "x" : 605, "y" : 825 } ] }, { "id" : 86055, "points" : [ { "x" : 605, "y" : 801 } ] }, { "id" : 86052, "points" : [ { "x" : 656, "y" : 779 } ] } ], "outputs" : [ { "id" : 86056, "points" : [ { "x" : 661, "y" : 873 } ] }, { "id" : 86051, "points" : [ { "x" : 757, "y" : 670 }, { "x" : 755, "y" : 850 } ] }, { "id" : 86057, "points" : [ { "x" : 630, "y" : 870 } ] } ], "catalysts" : [ { "id" : 86052, "points" : [ { "x" : 661, "y" : 779 } ] } ] }, { "id" : 86084, "reactomeId" : 10094359, "displayName" : "HTRA2 binds NDUFA13 (GRIM-19)", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 463, "y" : 1284 }, "minX" : 438, "maxX" : 484, "minY" : 1278, "maxY" : 1290, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 484, "y" : 1283 }, "to" : { "x" : 463, "y" : 1284 } }, { "from" : { "x" : 463, "y" : 1284 }, "to" : { "x" : 438, "y" : 1284 } } ], "endShape" : { "a" : { "x" : 445, "y" : 1280 }, "b" : { "x" : 438, "y" : 1284 }, "c" : { "x" : 445, "y" : 1288 }, "type" : "ARROW", "centre" : { "x" : 445, "y" : 1288 } }, "reactionShape" : { "c" : { "x" : 463, "y" : 1284 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 463, "y" : 1284 } }, "inputs" : [ { "id" : 86085, "points" : [ { "x" : 509, "y" : 1304 } ] }, { "id" : 86086, "points" : [ { "x" : 519, "y" : 1284 } ] } ], "outputs" : [ { "id" : 86087 } ] }, { "id" : 86088, "reactomeId" : 10094383, "displayName" : "HTRA2 degrades NDUFA13 (GRIM-19)", "schemaClass" : "BlackBoxEvent", "renderableClass" : "Reaction", "position" : { "x" : 256, "y" : 1283 }, "minX" : 229, "maxX" : 292, "minY" : 1269, "maxY" : 1289, "reactionType" : "omitted", "segments" : [ { "from" : { "x" : 292, "y" : 1269 }, "to" : { "x" : 256, "y" : 1283 } }, { "from" : { "x" : 256, "y" : 1283 }, "to" : { "x" : 229, "y" : 1284 } } ], "reactionShape" : { "a" : { "x" : 250, "y" : 1277 }, "b" : { "x" : 262, "y" : 1289 }, "s" : "\\\\", "type" : "BOX", "empty" : true, "centre" : { "x" : 256, "y" : 1283 } }, "inputs" : [ { "id" : 86087, "points" : [ { "x" : 306, "y" : 1272 } ] }, { "id" : 86089, "points" : [ { "x" : 320, "y" : 1252 } ] } ], "outputs" : [ { "id" : 86090, "points" : [ { "x" : 163, "y" : 1100 }, { "x" : 192, "y" : 1100 } ] }, { "id" : 86085, "points" : [ { "x" : 465, "y" : 1322 }, { "x" : 229, "y" : 1327 } ] }, { "id" : 86091, "points" : [ { "x" : 158, "y" : 1132 }, { "x" : 188, "y" : 1134 } ] }, { "id" : 86092, "points" : [ { "x" : 157, "y" : 1160 }, { "x" : 187, "y" : 1162 } ] }, { "id" : 86093, "points" : [ { "x" : 161, "y" : 1189 }, { "x" : 188, "y" : 1189 } ] }, { "id" : 86094, "points" : [ { "x" : 160, "y" : 1222 }, { "x" : 190, "y" : 1221 } ] }, { "id" : 86095, "points" : [ { "x" : 164, "y" : 1254 }, { "x" : 192, "y" : 1254 } ] }, { "id" : 86096, "points" : [ { "x" : 156, "y" : 1286 } ] } ], "catalysts" : [ { "id" : 86087, "points" : [ { "x" : 306, "y" : 1284 } ] } ] }, { "id" : 86026, "reactomeId" : 10094323, "displayName" : "PRKACA phosphorylates TFAM in the mitochondrial matrix", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 349, "y" : 115 }, "minX" : 343, "maxX" : 355, "minY" : 96, "maxY" : 137, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 347, "y" : 96 }, "to" : { "x" : 349, "y" : 115 } }, { "from" : { "x" : 349, "y" : 115 }, "to" : { "x" : 350, "y" : 137 } } ], "reactionShape" : { "a" : { "x" : 343, "y" : 109 }, "b" : { "x" : 355, "y" : 121 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 349, "y" : 115 } }, "inputs" : [ { "id" : 86027, "points" : [ { "x" : 372, "y" : 85 } ] }, { "id" : 86028, "points" : [ { "x" : 309, "y" : 84 } ], "stoichiometry" : 4 } ], "outputs" : [ { "id" : 86029, "points" : [ { "x" : 318, "y" : 158 } ], "stoichiometry" : 4 }, { "id" : 86030, "points" : [ { "x" : 400, "y" : 156 } ] } ], "catalysts" : [ { "id" : 86031, "points" : [ { "x" : 375, "y" : 113 } ] } ] }, { "id" : 86058, "reactomeId" : 10094388, "displayName" : "AFG3L2 binds mitochondrial matrix proteins", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 821, "y" : 229 }, "minX" : 800, "maxX" : 827, "minY" : 190, "maxY" : 256, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 824, "y" : 190 }, "to" : { "x" : 821, "y" : 229 } }, { "from" : { "x" : 821, "y" : 229 }, "to" : { "x" : 800, "y" : 256 } } ], "endShape" : { "a" : { "x" : 801, "y" : 248 }, "b" : { "x" : 800, "y" : 256 }, "c" : { "x" : 807, "y" : 253 }, "type" : "ARROW", "centre" : { "x" : 807, "y" : 253 } }, "reactionShape" : { "c" : { "x" : 821, "y" : 229 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 821, "y" : 229 } }, "inputs" : [ { "id" : 86059, "points" : [ { "x" : 932, "y" : 171 } ] }, { "id" : 86060, "points" : [ { "x" : 772, "y" : 180 } ] } ], "outputs" : [ { "id" : 86061 } ] }, { "id" : 86062, "reactomeId" : 10094366, "displayName" : "AFG3L2 degrades mitochondrial matrix proteins", "schemaClass" : "BlackBoxEvent", "renderableClass" : "Reaction", "position" : { "x" : 791, "y" : 343 }, "minX" : 785, "maxX" : 797, "minY" : 319, "maxY" : 366, "reactionType" : "omitted", "segments" : [ { "from" : { "x" : 790, "y" : 319 }, "to" : { "x" : 791, "y" : 343 } }, { "from" : { "x" : 791, "y" : 343 }, "to" : { "x" : 790, "y" : 366 } } ], "reactionShape" : { "a" : { "x" : 785, "y" : 337 }, "b" : { "x" : 797, "y" : 349 }, "s" : "\\\\", "type" : "BOX", "empty" : true, "centre" : { "x" : 791, "y" : 343 } }, "inputs" : [ { "id" : 86063, "points" : [ { "x" : 739, "y" : 346 } ] }, { "id" : 86064, "points" : [ { "x" : 739, "y" : 319 } ] }, { "id" : 86061, "points" : [ { "x" : 781, "y" : 300 } ] } ], "outputs" : [ { "id" : 86059, "points" : [ { "x" : 958, "y" : 171 }, { "x" : 885, "y" : 195 }, { "x" : 885, "y" : 362 } ] }, { "id" : 86065, "points" : [ { "x" : 797, "y" : 392 } ] }, { "id" : 86066, "points" : [ { "x" : 769, "y" : 383 } ] } ], "catalysts" : [ { "id" : 86061, "points" : [ { "x" : 788, "y" : 300 } ] } ] }, { "id" : 86097, "reactomeId" : 10094355, "displayName" : "HTRA2 degrades APP (Amyloid-beta precursor protein)", "schemaClass" : "BlackBoxEvent", "renderableClass" : "Reaction", "position" : { "x" : 764, "y" : 1322 }, "minX" : 758, "maxX" : 770, "minY" : 1298, "maxY" : 1373, "reactionType" : "omitted", "segments" : [ { "from" : { "x" : 764, "y" : 1298 }, "to" : { "x" : 764, "y" : 1322 } }, { "from" : { "x" : 764, "y" : 1322 }, "to" : { "x" : 763, "y" : 1373 } } ], "endShape" : { "a" : { "x" : 759, "y" : 1366 }, "b" : { "x" : 763, "y" : 1373 }, "c" : { "x" : 767, "y" : 1366 }, "type" : "ARROW", "centre" : { "x" : 767, "y" : 1366 } }, "reactionShape" : { "a" : { "x" : 758, "y" : 1316 }, "b" : { "x" : 770, "y" : 1328 }, "s" : "\\\\", "type" : "BOX", "empty" : true, "centre" : { "x" : 764, "y" : 1322 } }, "inputs" : [ { "id" : 86098, "points" : [ { "x" : 812, "y" : 1307 } ] }, { "id" : 86099, "points" : [ { "x" : 735, "y" : 1289 } ] } ], "outputs" : [ { "id" : 86100 } ], "catalysts" : [ { "id" : 86085, "points" : [ { "x" : 584, "y" : 1321 } ] } ] }, { "id" : 86032, "reactomeId" : 10094315, "displayName" : "LONP1 binds mitochondrial matrix proteins", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 396, "y" : 336 }, "minX" : 390, "maxX" : 402, "minY" : 311, "maxY" : 371, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 394, "y" : 311 }, "to" : { "x" : 396, "y" : 336 } }, { "from" : { "x" : 396, "y" : 336 }, "to" : { "x" : 397, "y" : 371 } } ], "endShape" : { "a" : { "x" : 393, "y" : 364 }, "b" : { "x" : 397, "y" : 371 }, "c" : { "x" : 401, "y" : 364 }, "type" : "ARROW", "centre" : { "x" : 401, "y" : 364 } }, "reactionShape" : { "c" : { "x" : 396, "y" : 336 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 396, "y" : 336 } }, "inputs" : [ { "id" : 86033, "points" : [ { "x" : 342, "y" : 303 } ] }, { "id" : 86034, "points" : [ { "x" : 420, "y" : 268 } ] } ], "outputs" : [ { "id" : 86035 } ] }, { "id" : 86067, "reactomeId" : 10094331, "displayName" : "AFG3L2 binds mitochondrial inner membrane proteins", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 1044, "y" : 219 }, "minX" : 1038, "maxX" : 1050, "minY" : 195, "maxY" : 244, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 1045, "y" : 195 }, "to" : { "x" : 1044, "y" : 219 } }, { "from" : { "x" : 1044, "y" : 219 }, "to" : { "x" : 1045, "y" : 244 } } ], "endShape" : { "a" : { "x" : 1041, "y" : 237 }, "b" : { "x" : 1045, "y" : 244 }, "c" : { "x" : 1049, "y" : 237 }, "type" : "ARROW", "centre" : { "x" : 1049, "y" : 237 } }, "reactionShape" : { "c" : { "x" : 1044, "y" : 219 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 1044, "y" : 219 } }, "inputs" : [ { "id" : 86068, "points" : [ { "x" : 1078, "y" : 131 }, { "x" : 1078, "y" : 180 } ] }, { "id" : 86059, "points" : [ { "x" : 1007, "y" : 171 } ] } ], "outputs" : [ { "id" : 86069 } ] }, { "id" : 86036, "reactomeId" : 10094313, "displayName" : "LONP1 degrades mitochondrial matrix proteins", "schemaClass" : "BlackBoxEvent", "renderableClass" : "Reaction", "position" : { "x" : 400, "y" : 482 }, "minX" : 394, "maxX" : 418, "minY" : 457, "maxY" : 518, "reactionType" : "omitted", "segments" : [ { "from" : { "x" : 418, "y" : 457 }, "to" : { "x" : 400, "y" : 482 } }, { "from" : { "x" : 400, "y" : 482 }, "to" : { "x" : 399, "y" : 518 } } ], "reactionShape" : { "a" : { "x" : 394, "y" : 476 }, "b" : { "x" : 406, "y" : 488 }, "s" : "\\\\", "type" : "BOX", "empty" : true, "centre" : { "x" : 400, "y" : 482 } }, "inputs" : [ { "id" : 86037, "points" : [ { "x" : 451, "y" : 444 } ] }, { "id" : 86035, "points" : [ { "x" : 404, "y" : 418 } ] }, { "id" : 86038, "points" : [ { "x" : 452, "y" : 471 } ] } ], "outputs" : [ { "id" : 86039, "points" : [ { "x" : 424, "y" : 536 } ] }, { "id" : 86040, "points" : [ { "x" : 398, "y" : 551 } ] }, { "id" : 86033, "points" : [ { "x" : 281, "y" : 313 }, { "x" : 290, "y" : 518 } ] } ], "catalysts" : [ { "id" : 86035, "points" : [ { "x" : 398, "y" : 418 } ] } ] }, { "id" : 86070, "reactomeId" : 10094386, "displayName" : "AFG3L2 degrades mitochondrial inner membrane proteins", "schemaClass" : "BlackBoxEvent", "renderableClass" : "Reaction", "position" : { "x" : 1045, "y" : 364 }, "minX" : 1039, "maxX" : 1051, "minY" : 328, "maxY" : 381, "reactionType" : "omitted", "segments" : [ { "from" : { "x" : 1040, "y" : 328 }, "to" : { "x" : 1045, "y" : 364 } }, { "from" : { "x" : 1045, "y" : 364 }, "to" : { "x" : 1045, "y" : 381 } } ], "reactionShape" : { "a" : { "x" : 1039, "y" : 358 }, "b" : { "x" : 1051, "y" : 370 }, "s" : "\\\\", "type" : "BOX", "empty" : true, "centre" : { "x" : 1045, "y" : 364 } }, "inputs" : [ { "id" : 86071, "points" : [ { "x" : 992, "y" : 342 } ] }, { "id" : 86069, "points" : [ { "x" : 1044, "y" : 294 } ] }, { "id" : 86072, "points" : [ { "x" : 989, "y" : 316 } ] } ], "outputs" : [ { "id" : 86059, "points" : [ { "x" : 982, "y" : 171 }, { "x" : 921, "y" : 260 }, { "x" : 925, "y" : 384 } ] }, { "id" : 86073, "points" : [ { "x" : 1014, "y" : 418 } ] }, { "id" : 86074, "points" : [ { "x" : 976, "y" : 419 } ] } ], "catalysts" : [ { "id" : 86069, "points" : [ { "x" : 1046, "y" : 294 } ] } ] }, { "id" : 86041, "reactomeId" : 10094245, "displayName" : "LONP1 binds mitochondrial inner membrane proteins", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 165, "y" : 343 }, "minX" : 159, "maxX" : 171, "minY" : 316, "maxY" : 370, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 164, "y" : 316 }, "to" : { "x" : 165, "y" : 343 } }, { "from" : { "x" : 165, "y" : 343 }, "to" : { "x" : 166, "y" : 370 } } ], "endShape" : { "a" : { "x" : 162, "y" : 363 }, "b" : { "x" : 166, "y" : 370 }, "c" : { "x" : 170, "y" : 363 }, "type" : "ARROW", "centre" : { "x" : 170, "y" : 363 } }, "reactionShape" : { "c" : { "x" : 165, "y" : 343 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 165, "y" : 343 } }, "inputs" : [ { "id" : 86042, "points" : [ { "x" : 136, "y" : 266 } ] }, { "id" : 86033, "points" : [ { "x" : 221, "y" : 305 } ] } ], "outputs" : [ { "id" : 86043 } ] }, { "id" : 86075, "reactomeId" : 10094339, "displayName" : "AFG3L2:SPG7 binds SMDT1 (EMRE)", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 102, "y" : 783 }, "minX" : 96, "maxX" : 108, "minY" : 762, "maxY" : 807, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 99, "y" : 762 }, "to" : { "x" : 102, "y" : 783 } }, { "from" : { "x" : 102, "y" : 783 }, "to" : { "x" : 100, "y" : 807 } } ], "endShape" : { "a" : { "x" : 97, "y" : 800 }, "b" : { "x" : 100, "y" : 807 }, "c" : { "x" : 105, "y" : 800 }, "type" : "ARROW", "centre" : { "x" : 105, "y" : 800 } }, "reactionShape" : { "c" : { "x" : 102, "y" : 783 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 102, "y" : 783 } }, "inputs" : [ { "id" : 86076, "points" : [ { "x" : 64, "y" : 656 }, { "x" : 20, "y" : 679 }, { "x" : 21, "y" : 756 } ] }, { "id" : 86077, "points" : [ { "x" : 99, "y" : 743 } ] } ], "outputs" : [ { "id" : 86078 } ] }, { "id" : 86044, "reactomeId" : 10094248, "displayName" : "LONP1 degrades mitochondrial inner membrane proteins", "schemaClass" : "BlackBoxEvent", "renderableClass" : "Reaction", "position" : { "x" : 173, "y" : 500 }, "minX" : 162, "maxX" : 179, "minY" : 474, "maxY" : 522, "reactionType" : "omitted", "segments" : [ { "from" : { "x" : 162, "y" : 474 }, "to" : { "x" : 173, "y" : 500 } }, { "from" : { "x" : 173, "y" : 500 }, "to" : { "x" : 174, "y" : 522 } } ], "reactionShape" : { "a" : { "x" : 167, "y" : 494 }, "b" : { "x" : 179, "y" : 506 }, "s" : "\\\\", "type" : "BOX", "empty" : true, "centre" : { "x" : 173, "y" : 500 } }, "inputs" : [ { "id" : 86045, "points" : [ { "x" : 136, "y" : 477 } ] }, { "id" : 86043, "points" : [ { "x" : 165, "y" : 421 } ] }, { "id" : 86046, "points" : [ { "x" : 137, "y" : 455 } ] } ], "outputs" : [ { "id" : 86047, "points" : [ { "x" : 144, "y" : 538 } ] }, { "id" : 86033, "points" : [ { "x" : 281, "y" : 313 }, { "x" : 281, "y" : 521 } ] }, { "id" : 86048, "points" : [ { "x" : 170, "y" : 552 } ] } ], "catalysts" : [ { "id" : 86043, "points" : [ { "x" : 168, "y" : 421 } ] } ] }, { "id" : 86079, "reactomeId" : 10094342, "displayName" : "AFG3L2:SPG7 degrades SMDT1 (EMRE)", "schemaClass" : "BlackBoxEvent", "renderableClass" : "Reaction", "position" : { "x" : 100, "y" : 934 }, "minX" : 94, "maxX" : 106, "minY" : 896, "maxY" : 960, "reactionType" : "omitted", "segments" : [ { "from" : { "x" : 97, "y" : 896 }, "to" : { "x" : 100, "y" : 934 } }, { "from" : { "x" : 100, "y" : 934 }, "to" : { "x" : 98, "y" : 960 } } ], "reactionShape" : { "a" : { "x" : 94, "y" : 928 }, "b" : { "x" : 106, "y" : 940 }, "s" : "\\\\", "type" : "BOX", "empty" : true, "centre" : { "x" : 100, "y" : 934 } }, "inputs" : [ { "id" : 86080, "points" : [ { "x" : 133, "y" : 904 } ] }, { "id" : 86081, "points" : [ { "x" : 130, "y" : 882 } ] }, { "id" : 86078, "points" : [ { "x" : 99, "y" : 851 } ] } ], "outputs" : [ { "id" : 86082, "points" : [ { "x" : 118, "y" : 1011 } ] }, { "id" : 86077, "points" : [ { "x" : 144, "y" : 743 }, { "x" : 187, "y" : 767 }, { "x" : 190, "y" : 960 } ] }, { "id" : 86083, "points" : [ { "x" : 127, "y" : 982 } ] } ], "catalysts" : [ { "id" : 86078, "points" : [ { "x" : 100, "y" : 851 } ] } ] } ], "compartments" : [ { "id" : 86101, "reactomeId" : 5460, "displayName" : "mitochondrial matrix", "schemaClass" : "Compartment", "renderableClass" : "Compartment", "position" : { "x" : 555, "y" : 662 }, "minX" : 71, "maxX" : 1039, "minY" : 35, "maxY" : 1289, "prop" : { "x" : 71, "y" : 35, "width" : 968, "height" : 1254 }, "textPosition" : { "x" : 369, "y" : 1056 }, "insets" : { "x" : 81, "y" : 45, "width" : 948, "height" : 1234 }, "bgColor" : { "r" : 250, "g" : 240, "b" : 240 }, "componentIds" : [ 86027, 86028, 86031, 86026, 86029, 86030, 86032, 86033, 86034, 86112, 86035, 86036, 86038, 86037, 86039, 86040, 86041, 86042, 86043, 86044, 86045, 86046, 86047, 86048, 86049, 86050, 86113, 86114, 86051, 86052, 86053, 86056, 86055, 86054, 86057, 86058, 86059, 86060, 86115, 86116, 86061, 86062, 86063, 86064, 86065, 86066, 86068, 86069, 86071, 86072, 86073, 86074, 86076, 86077, 86078, 86079, 86080, 86081, 86082, 86075, 86083, 86087, 86084, 86086, 86088, 86090, 86091, 86092, 86093, 86094, 86095, 86096, 86089, 86099 ] }, { "id" : 86102, "reactomeId" : 5462, "displayName" : "mitochondrion", "schemaClass" : "Compartment", "renderableClass" : "Compartment", "position" : { "x" : 639, "y" : 684 }, "minX" : 0, "maxX" : 1279, "minY" : 0, "maxY" : 1368, "prop" : { "x" : 0, "y" : 0, "width" : 1279, "height" : 1368 }, "textPosition" : { "x" : 20, "y" : 1306 }, "insets" : { "x" : 10, "y" : 10, "width" : 1259, "height" : 1348 }, "bgColor" : { "r" : 250, "g" : 240, "b" : 240 }, "componentIds" : [ 86101, 86070, 86085, 86067, 86098, 86097 ] } ], "notes" : [ ], "links" : [ { "id" : 86113, "renderableClass" : "EntitySetAndMemberLink", "position" : { "x" : 561, "y" : 84 }, "minX" : 430, "maxX" : 567, "minY" : 71, "maxY" : 628, "segments" : [ { "from" : { "x" : 430, "y" : 71 }, "to" : { "x" : 561, "y" : 84 } }, { "from" : { "x" : 561, "y" : 84 }, "to" : { "x" : 548, "y" : 628 } } ], "reactionShape" : { "a" : { "x" : 555, "y" : 78 }, "b" : { "x" : 567, "y" : 90 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 561, "y" : 84 } }, "inputs" : [ { "id" : 86027 } ], "outputs" : [ { "id" : 86050 } ] }, { "id" : 86112, "renderableClass" : "EntitySetAndMemberLink", "position" : { "x" : 435, "y" : 205 }, "minX" : 429, "maxX" : 441, "minY" : 195, "maxY" : 215, "segments" : [ { "from" : { "x" : 437, "y" : 195 }, "to" : { "x" : 434, "y" : 215 } } ], "reactionShape" : { "a" : { "x" : 429, "y" : 199 }, "b" : { "x" : 441, "y" : 211 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 435, "y" : 205 } }, "inputs" : [ { "id" : 86030 } ], "outputs" : [ { "id" : 86034 } ] }, { "id" : 86115, "renderableClass" : "EntitySetAndEntitySetLink", "position" : { "x" : 631, "y" : 404 }, "minX" : 555, "maxX" : 707, "minY" : 180, "maxY" : 628, "segments" : [ { "from" : { "x" : 707, "y" : 180 }, "to" : { "x" : 555, "y" : 628 } } ], "reactionShape" : { "a" : { "x" : 625, "y" : 398 }, "b" : { "x" : 637, "y" : 410 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 631, "y" : 404 } }, "inputs" : [ { "id" : 86060 } ], "outputs" : [ { "id" : 86050 } ] }, { "id" : 86114, "renderableClass" : "EntitySetAndEntitySetLink", "position" : { "x" : 546, "y" : 247 }, "minX" : 528, "maxX" : 552, "minY" : 241, "maxY" : 628, "segments" : [ { "from" : { "x" : 547, "y" : 628 }, "to" : { "x" : 546, "y" : 247 } }, { "from" : { "x" : 546, "y" : 247 }, "to" : { "x" : 528, "y" : 245 } } ], "reactionShape" : { "a" : { "x" : 540, "y" : 241 }, "b" : { "x" : 552, "y" : 253 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 546, "y" : 247 } }, "inputs" : [ { "id" : 86050 } ], "outputs" : [ { "id" : 86034 } ] }, { "id" : 86116, "renderableClass" : "EntitySetAndEntitySetLink", "position" : { "x" : 576, "y" : 197 }, "minX" : 504, "maxX" : 649, "minY" : 180, "maxY" : 215, "segments" : [ { "from" : { "x" : 649, "y" : 180 }, "to" : { "x" : 504, "y" : 215 } } ], "reactionShape" : { "a" : { "x" : 570, "y" : 191 }, "b" : { "x" : 582, "y" : 203 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 576, "y" : 197 } }, "inputs" : [ { "id" : 86060 } ], "outputs" : [ { "id" : 86034 } ] } ], "shadows" : [ ], "minX" : 0, "maxX" : 1279, "minY" : 0, "maxY" : 1412, "disease" : false }