{
  "dbId" : 10101319,
  "stableId" : "R-MMU-8951664",
  "displayName" : "Neddylation",
  "nodes" : [ {
    "id" : 79488,
    "reactomeId" : 10083662,
    "displayName" : "NEDD8-CRL2 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 2193,
      "y" : 824
    },
    "minX" : 2084,
    "maxX" : 2263,
    "minY" : 786,
    "maxY" : 856,
    "prop" : {
      "x" : 2130,
      "y" : 792,
      "width" : 127,
      "height" : 64
    },
    "textPosition" : {
      "x" : 2134,
      "y" : 793
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 2257,
          "y" : 792
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 2257,
          "y" : 792
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 79487,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 2127,
          "y" : 824
        },
        "to" : {
          "x" : 2084,
          "y" : 825
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 2120,
          "y" : 828
        },
        "b" : {
          "x" : 2127,
          "y" : 824
        },
        "c" : {
          "x" : 2120,
          "y" : 820
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 2120,
          "y" : 820
        }
      }
    } ]
  }, {
    "id" : 79491,
    "reactomeId" : 10083669,
    "displayName" : "NEDD8-AcM-UBE2M:CRL3 E3 ubiquitin ligase :DCUN1D1,2,4,5",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 1834,
      "y" : 998
    },
    "minX" : 1756,
    "maxX" : 2047,
    "minY" : 960,
    "maxY" : 1031,
    "prop" : {
      "x" : 1756,
      "y" : 966,
      "width" : 156,
      "height" : 65
    },
    "textPosition" : {
      "x" : 1759,
      "y" : 982
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1912,
          "y" : 966
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1912,
          "y" : 966
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 79489,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 79492,
      "type" : "INPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 79492,
      "type" : "CATALYST",
      "segments" : [ {
        "from" : {
          "x" : 1915,
          "y" : 987
        },
        "to" : {
          "x" : 2029,
          "y" : 972
        }
      }, {
        "from" : {
          "x" : 2029,
          "y" : 972
        },
        "to" : {
          "x" : 2041,
          "y" : 995
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 2043,
          "y" : 998
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 2043,
          "y" : 998
        }
      }
    } ]
  }, {
    "id" : 79490,
    "reactomeId" : 10083667,
    "displayName" : "CRL3 E3 ubiquitin ligase:COMMDs:CCDC22",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 1386,
      "y" : 1052
    },
    "minX" : 1319,
    "maxX" : 1693,
    "minY" : 998,
    "maxY" : 1078,
    "prop" : {
      "x" : 1319,
      "y" : 1026,
      "width" : 134,
      "height" : 52
    },
    "textPosition" : {
      "x" : 1326,
      "y" : 1029
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1453,
          "y" : 1026
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1453,
          "y" : 1026
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 79489,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1456,
          "y" : 1040
        },
        "to" : {
          "x" : 1693,
          "y" : 998
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 79493,
    "reactomeId" : 10083678,
    "displayName" : "NEDD8-CRL3 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 2157,
      "y" : 1003
    },
    "minX" : 2081,
    "maxX" : 2223,
    "minY" : 959,
    "maxY" : 1042,
    "prop" : {
      "x" : 2097,
      "y" : 965,
      "width" : 120,
      "height" : 77
    },
    "textPosition" : {
      "x" : 2098,
      "y" : 979
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 2217,
          "y" : 965
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 2217,
          "y" : 965
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 79492,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 2094,
          "y" : 1007
        },
        "to" : {
          "x" : 2081,
          "y" : 1009
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 2088,
          "y" : 1012
        },
        "b" : {
          "x" : 2094,
          "y" : 1007
        },
        "c" : {
          "x" : 2087,
          "y" : 1004
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 2087,
          "y" : 1004
        }
      }
    } ]
  }, {
    "id" : 79495,
    "reactomeId" : 10083769,
    "displayName" : "DCUN1D1,2,4,5",
    "schemaClass" : "CandidateSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 1214,
      "y" : 1570
    },
    "minX" : 1138,
    "maxX" : 1290,
    "minY" : 1469,
    "maxY" : 1591,
    "prop" : {
      "x" : 1138,
      "y" : 1549,
      "width" : 152,
      "height" : 42
    },
    "textPosition" : {
      "x" : 1162,
      "y" : 1559
    },
    "connectors" : [ {
      "edgeId" : 79494,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1219,
          "y" : 1543
        },
        "to" : {
          "x" : 1242,
          "y" : 1469
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 79497,
    "reactomeId" : 10083759,
    "displayName" : "CRL4 E3 ubiquitin ligase:COMMDs:CCDC22",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 1151,
      "y" : 1459
    },
    "minX" : 1037,
    "maxX" : 1242,
    "minY" : 1428,
    "maxY" : 1485,
    "prop" : {
      "x" : 1089,
      "y" : 1434,
      "width" : 125,
      "height" : 51
    },
    "textPosition" : {
      "x" : 1091,
      "y" : 1436
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1214,
          "y" : 1434
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1214,
          "y" : 1434
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 79494,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1217,
          "y" : 1465
        },
        "to" : {
          "x" : 1242,
          "y" : 1469
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 79513,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 1086,
          "y" : 1461
        },
        "to" : {
          "x" : 1037,
          "y" : 1463
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 1079,
          "y" : 1465
        },
        "b" : {
          "x" : 1086,
          "y" : 1461
        },
        "c" : {
          "x" : 1079,
          "y" : 1457
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 1079,
          "y" : 1457
        }
      }
    } ]
  }, {
    "id" : 79496,
    "reactomeId" : 10083687,
    "displayName" : "NEDD8-AcM-UBE2M",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 1364,
      "y" : 1560
    },
    "minX" : 1242,
    "maxX" : 1417,
    "minY" : 1469,
    "maxY" : 1578,
    "prop" : {
      "x" : 1318,
      "y" : 1542,
      "width" : 93,
      "height" : 36
    },
    "textPosition" : {
      "x" : 1322,
      "y" : 1543
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1411,
          "y" : 1542
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1411,
          "y" : 1542
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 79494,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1339,
          "y" : 1539
        },
        "to" : {
          "x" : 1242,
          "y" : 1469
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 79498,
    "reactomeId" : 10083771,
    "displayName" : "NEDD8-AcM-UBE2M:CRL4 E3 ubiquitin ligase:COMMDs:CCDC22:DCUND1,2,4,5",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 1418,
      "y" : 1469
    },
    "minX" : 1352,
    "maxX" : 1550,
    "minY" : 1419,
    "maxY" : 1513,
    "prop" : {
      "x" : 1352,
      "y" : 1425,
      "width" : 133,
      "height" : 88
    },
    "textPosition" : {
      "x" : 1353,
      "y" : 1436
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1485,
          "y" : 1425
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1485,
          "y" : 1425
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 79494,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 79499,
      "type" : "INPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 79499,
      "type" : "CATALYST",
      "segments" : [ {
        "from" : {
          "x" : 1488,
          "y" : 1447
        },
        "to" : {
          "x" : 1521,
          "y" : 1436
        }
      }, {
        "from" : {
          "x" : 1521,
          "y" : 1436
        },
        "to" : {
          "x" : 1543,
          "y" : 1461
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 1546,
          "y" : 1464
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1546,
          "y" : 1464
        }
      }
    } ]
  }, {
    "id" : 79501,
    "reactomeId" : 10083773,
    "displayName" : "Ube2m",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 1645,
      "y" : 1533
    },
    "minX" : 1586,
    "maxX" : 1701,
    "minY" : 1472,
    "maxY" : 1551,
    "prop" : {
      "x" : 1596,
      "y" : 1515,
      "width" : 99,
      "height" : 36
    },
    "textPosition" : {
      "x" : 1619,
      "y" : 1522
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1695,
          "y" : 1515
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1695,
          "y" : 1515
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 79499,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 1627,
          "y" : 1512
        },
        "to" : {
          "x" : 1586,
          "y" : 1472
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 1619,
          "y" : 1510
        },
        "b" : {
          "x" : 1627,
          "y" : 1512
        },
        "c" : {
          "x" : 1625,
          "y" : 1504
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 1625,
          "y" : 1504
        }
      }
    } ]
  }, {
    "id" : 79500,
    "reactomeId" : 10083785,
    "displayName" : "NEDD8-CRL4 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 1732,
      "y" : 1470
    },
    "minX" : 1586,
    "maxX" : 1813,
    "minY" : 1431,
    "maxY" : 1503,
    "prop" : {
      "x" : 1658,
      "y" : 1437,
      "width" : 149,
      "height" : 66
    },
    "textPosition" : {
      "x" : 1673,
      "y" : 1440
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1807,
          "y" : 1437
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1807,
          "y" : 1437
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 79499,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 1655,
          "y" : 1471
        },
        "to" : {
          "x" : 1586,
          "y" : 1472
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 1648,
          "y" : 1475
        },
        "b" : {
          "x" : 1655,
          "y" : 1471
        },
        "c" : {
          "x" : 1648,
          "y" : 1467
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 1648,
          "y" : 1467
        }
      }
    }, {
      "edgeId" : 79519,
      "type" : "INPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 79503,
    "reactomeId" : 10084041,
    "displayName" : "CRL E3 ubiquitin ligases",
    "schemaClass" : "DefinedSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 438,
      "y" : 1206
    },
    "minX" : 383,
    "maxX" : 607,
    "minY" : 1170,
    "maxY" : 1224,
    "prop" : {
      "x" : 383,
      "y" : 1188,
      "width" : 110,
      "height" : 36
    },
    "textPosition" : {
      "x" : 382,
      "y" : 1188
    },
    "connectors" : [ {
      "edgeId" : 79502,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 499,
          "y" : 1194
        },
        "to" : {
          "x" : 607,
          "y" : 1170
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 79505,
    "reactomeId" : 10084043,
    "displayName" : "CRL E3 ubiquitin ligase:CAND1",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 748,
      "y" : 1179
    },
    "minX" : 698,
    "maxX" : 889,
    "minY" : 1148,
    "maxY" : 1204,
    "prop" : {
      "x" : 698,
      "y" : 1154,
      "width" : 101,
      "height" : 50
    },
    "textPosition" : {
      "x" : 703,
      "y" : 1155
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 799,
          "y" : 1154
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 799,
          "y" : 1154
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 79502,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 79506,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 802,
          "y" : 1177
        },
        "to" : {
          "x" : 889,
          "y" : 1175
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 79504,
    "reactomeId" : 10062907,
    "displayName" : "Cand1",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 525,
      "y" : 1131
    },
    "minX" : 500,
    "maxX" : 1028,
    "minY" : 1114,
    "maxY" : 1172,
    "prop" : {
      "x" : 500,
      "y" : 1120,
      "width" : 51,
      "height" : 22
    },
    "textPosition" : {
      "x" : 501,
      "y" : 1120
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 551,
          "y" : 1120
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 551,
          "y" : 1120
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 79502,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 548,
          "y" : 1145
        },
        "to" : {
          "x" : 607,
          "y" : 1170
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 79506,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 554,
          "y" : 1130
        },
        "to" : {
          "x" : 967,
          "y" : 1121
        }
      }, {
        "from" : {
          "x" : 967,
          "y" : 1121
        },
        "to" : {
          "x" : 1028,
          "y" : 1172
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 561,
          "y" : 1126
        },
        "b" : {
          "x" : 554,
          "y" : 1130
        },
        "c" : {
          "x" : 561,
          "y" : 1134
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 561,
          "y" : 1134
        }
      }
    } ]
  }, {
    "id" : 79507,
    "reactomeId" : 10082860,
    "displayName" : "COMMDs:CCDC22",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 703,
      "y" : 1260
    },
    "minX" : 655,
    "maxX" : 889,
    "minY" : 1175,
    "maxY" : 1278,
    "prop" : {
      "x" : 655,
      "y" : 1242,
      "width" : 96,
      "height" : 36
    },
    "textPosition" : {
      "x" : 670,
      "y" : 1243
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 751,
          "y" : 1242
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 751,
          "y" : 1242
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 79506,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 742,
          "y" : 1239
        },
        "to" : {
          "x" : 889,
          "y" : 1175
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 79508,
    "reactomeId" : 10084055,
    "displayName" : "CRL E3 ubiquitin ligase:COMMDs:CCDC22",
    "schemaClass" : "DefinedSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 1144,
      "y" : 1183
    },
    "minX" : 1028,
    "maxX" : 1210,
    "minY" : 1161,
    "maxY" : 1206,
    "prop" : {
      "x" : 1078,
      "y" : 1161,
      "width" : 132,
      "height" : 45
    },
    "textPosition" : {
      "x" : 1088,
      "y" : 1159
    },
    "connectors" : [ {
      "edgeId" : 79506,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 1072,
          "y" : 1176
        },
        "to" : {
          "x" : 1028,
          "y" : 1172
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 1065,
          "y" : 1179
        },
        "b" : {
          "x" : 1072,
          "y" : 1176
        },
        "c" : {
          "x" : 1065,
          "y" : 1171
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 1065,
          "y" : 1171
        }
      }
    } ]
  }, {
    "id" : 79511,
    "reactomeId" : 10084047,
    "displayName" : "Cand1",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 689,
      "y" : 1538
    },
    "minX" : 661,
    "maxX" : 1069,
    "minY" : 1463,
    "maxY" : 1555,
    "prop" : {
      "x" : 661,
      "y" : 1527,
      "width" : 56,
      "height" : 22
    },
    "textPosition" : {
      "x" : 665,
      "y" : 1527
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 717,
          "y" : 1527
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 717,
          "y" : 1527
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 79509,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 697,
          "y" : 1524
        },
        "to" : {
          "x" : 743,
          "y" : 1470
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 79513,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 720,
          "y" : 1539
        },
        "to" : {
          "x" : 1069,
          "y" : 1555
        }
      }, {
        "from" : {
          "x" : 1069,
          "y" : 1555
        },
        "to" : {
          "x" : 1037,
          "y" : 1463
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 727,
          "y" : 1535
        },
        "b" : {
          "x" : 720,
          "y" : 1539
        },
        "c" : {
          "x" : 727,
          "y" : 1543
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 727,
          "y" : 1543
        }
      }
    } ]
  }, {
    "id" : 79510,
    "reactomeId" : 10083731,
    "displayName" : "RBX1:CUL4:DDB1:DCAFs",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 639,
      "y" : 1461
    },
    "minX" : 578,
    "maxX" : 743,
    "minY" : 1437,
    "maxY" : 1479,
    "prop" : {
      "x" : 578,
      "y" : 1443,
      "width" : 123,
      "height" : 36
    },
    "textPosition" : {
      "x" : 581,
      "y" : 1444
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 701,
          "y" : 1443
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 701,
          "y" : 1443
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 79509,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 704,
          "y" : 1466
        },
        "to" : {
          "x" : 743,
          "y" : 1470
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 79512,
    "reactomeId" : 10084049,
    "displayName" : "CRL4 E3 ubiquitin ligase:CAND1",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 865,
      "y" : 1472
    },
    "minX" : 797,
    "maxX" : 963,
    "minY" : 1448,
    "maxY" : 1490,
    "prop" : {
      "x" : 797,
      "y" : 1454,
      "width" : 137,
      "height" : 36
    },
    "textPosition" : {
      "x" : 805,
      "y" : 1455
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 934,
          "y" : 1454
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 934,
          "y" : 1454
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 79509,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 79513,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 937,
          "y" : 1468
        },
        "to" : {
          "x" : 963,
          "y" : 1467
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 79514,
    "reactomeId" : 10083757,
    "displayName" : "COMMDs:CCDC22",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 939,
      "y" : 1519
    },
    "minX" : 887,
    "maxX" : 998,
    "minY" : 1467,
    "maxY" : 1537,
    "prop" : {
      "x" : 887,
      "y" : 1501,
      "width" : 105,
      "height" : 36
    },
    "textPosition" : {
      "x" : 907,
      "y" : 1502
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 992,
          "y" : 1501
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 992,
          "y" : 1501
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 79513,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 947,
          "y" : 1498
        },
        "to" : {
          "x" : 963,
          "y" : 1467
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 79517,
    "reactomeId" : 10084105,
    "displayName" : "CRL E3 ubiquitin ligase complex:COMMDs:CCDC22:DCUN1Ds",
    "schemaClass" : "DefinedSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 3090,
      "y" : 669
    },
    "minX" : 2951,
    "maxX" : 3167,
    "minY" : 638,
    "maxY" : 700,
    "prop" : {
      "x" : 3013,
      "y" : 638,
      "width" : 154,
      "height" : 62
    },
    "textPosition" : {
      "x" : 3013,
      "y" : 644
    },
    "connectors" : [ {
      "edgeId" : 79515,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 3007,
          "y" : 667
        },
        "to" : {
          "x" : 2951,
          "y" : 667
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 3000,
          "y" : 671
        },
        "b" : {
          "x" : 3007,
          "y" : 667
        },
        "c" : {
          "x" : 3000,
          "y" : 663
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 3000,
          "y" : 663
        }
      }
    } ]
  }, {
    "id" : 79516,
    "reactomeId" : 10084095,
    "displayName" : "NEDD8 CRL E3 ubiquitin ligases:COMMDs:CCDC22:DCUN1Ds",
    "schemaClass" : "DefinedSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 2745,
      "y" : 674
    },
    "minX" : 2667,
    "maxX" : 2823,
    "minY" : 636,
    "maxY" : 712,
    "prop" : {
      "x" : 2667,
      "y" : 636,
      "width" : 156,
      "height" : 76
    },
    "textPosition" : {
      "x" : 2666,
      "y" : 649
    },
    "connectors" : [ {
      "edgeId" : 79515,
      "type" : "INPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 79518,
    "reactomeId" : 10077411,
    "displayName" : "COP9",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 2866,
      "y" : 612
    },
    "minX" : 2836,
    "maxX" : 2904,
    "minY" : 592,
    "maxY" : 663,
    "prop" : {
      "x" : 2836,
      "y" : 598,
      "width" : 60,
      "height" : 28
    },
    "textPosition" : {
      "x" : 2845,
      "y" : 605
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 2896,
          "y" : 598
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 2896,
          "y" : 598
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 79515,
      "type" : "CATALYST",
      "segments" : [ {
        "from" : {
          "x" : 2876,
          "y" : 629
        },
        "to" : {
          "x" : 2897,
          "y" : 655
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 2900,
          "y" : 659
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 2900,
          "y" : 659
        }
      }
    } ]
  }, {
    "id" : 79521,
    "reactomeId" : 10084110,
    "displayName" : "Nedd8",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 2017,
      "y" : 1565
    },
    "minX" : 1959,
    "maxX" : 2061,
    "minY" : 1476,
    "maxY" : 1580,
    "prop" : {
      "x" : 1979,
      "y" : 1551,
      "width" : 76,
      "height" : 29
    },
    "textPosition" : {
      "x" : 1992,
      "y" : 1555
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 2055,
          "y" : 1551
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 2055,
          "y" : 1551
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 79519,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 2007,
          "y" : 1548
        },
        "to" : {
          "x" : 1959,
          "y" : 1476
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 2000,
          "y" : 1544
        },
        "b" : {
          "x" : 2007,
          "y" : 1548
        },
        "c" : {
          "x" : 2006,
          "y" : 1540
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 2006,
          "y" : 1540
        }
      }
    } ]
  }, {
    "id" : 79520,
    "reactomeId" : 10084112,
    "displayName" : "CRL4 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 2074,
      "y" : 1476
    },
    "minX" : 1959,
    "maxX" : 2147,
    "minY" : 1435,
    "maxY" : 1511,
    "prop" : {
      "x" : 2007,
      "y" : 1441,
      "width" : 134,
      "height" : 70
    },
    "textPosition" : {
      "x" : 2011,
      "y" : 1448
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 2141,
          "y" : 1441
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 2141,
          "y" : 1441
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 79519,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 2004,
          "y" : 1476
        },
        "to" : {
          "x" : 1959,
          "y" : 1476
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 1997,
          "y" : 1480
        },
        "b" : {
          "x" : 2004,
          "y" : 1476
        },
        "c" : {
          "x" : 1997,
          "y" : 1472
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 1997,
          "y" : 1472
        }
      }
    } ]
  }, {
    "id" : 79522,
    "reactomeId" : 10062877,
    "displayName" : "COP9 signalosome",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 1885,
      "y" : 1536
    },
    "minX" : 1830,
    "maxX" : 1947,
    "minY" : 1481,
    "maxY" : 1554,
    "prop" : {
      "x" : 1830,
      "y" : 1518,
      "width" : 111,
      "height" : 36
    },
    "textPosition" : {
      "x" : 1842,
      "y" : 1519
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1941,
          "y" : 1518
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1941,
          "y" : 1518
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 79519,
      "type" : "CATALYST",
      "segments" : [ {
        "from" : {
          "x" : 1883,
          "y" : 1515
        },
        "to" : {
          "x" : 1882,
          "y" : 1489
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 1882,
          "y" : 1485
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1882,
          "y" : 1485
        }
      }
    } ]
  }, {
    "id" : 79525,
    "reactomeId" : 10028888,
    "displayName" : "hydroxyPro-HIF-alpha",
    "schemaClass" : "DefinedSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 2800,
      "y" : 824
    },
    "minX" : 2747,
    "maxX" : 2853,
    "minY" : 806,
    "maxY" : 877,
    "prop" : {
      "x" : 2747,
      "y" : 806,
      "width" : 106,
      "height" : 36
    },
    "textPosition" : {
      "x" : 2748,
      "y" : 806
    },
    "connectors" : [ {
      "edgeId" : 79523,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 2813,
          "y" : 848
        },
        "to" : {
          "x" : 2841,
          "y" : 877
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 79524,
    "reactomeId" : 10084117,
    "displayName" : "RBX1:NEDD8-CUL2:EloB,C:VHL:COMMDs:CCDC22:DCUN1D1,2,4,5",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 2677,
      "y" : 896
    },
    "minX" : 2593,
    "maxX" : 3663,
    "minY" : 755,
    "maxY" : 959,
    "prop" : {
      "x" : 2593,
      "y" : 865,
      "width" : 168,
      "height" : 62
    },
    "textPosition" : {
      "x" : 2593,
      "y" : 878
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 2761,
          "y" : 865
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 2761,
          "y" : 865
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 79560,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 2746,
          "y" : 930
        },
        "to" : {
          "x" : 2818,
          "y" : 959
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 79523,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 2764,
          "y" : 886
        },
        "to" : {
          "x" : 2841,
          "y" : 877
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 79547,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 2694,
          "y" : 862
        },
        "to" : {
          "x" : 2752,
          "y" : 766
        }
      }, {
        "from" : {
          "x" : 2752,
          "y" : 766
        },
        "to" : {
          "x" : 3663,
          "y" : 755
        }
      }, {
        "from" : {
          "x" : 3663,
          "y" : 755
        },
        "to" : {
          "x" : 3627,
          "y" : 873
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 2694,
          "y" : 854
        },
        "b" : {
          "x" : 2694,
          "y" : 862
        },
        "c" : {
          "x" : 2701,
          "y" : 858
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 2701,
          "y" : 858
        }
      }
    } ]
  }, {
    "id" : 79526,
    "reactomeId" : 10084130,
    "displayName" : "RBX1:NEDD8-CUL2:EloB,C:VHL:COMMDs:CCDC22:DCUN1D1,2,4,5:hydroxyPro-HIF-alpha",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 3025,
      "y" : 862
    },
    "minX" : 2918,
    "maxX" : 3259,
    "minY" : 776,
    "maxY" : 891,
    "prop" : {
      "x" : 2918,
      "y" : 834,
      "width" : 215,
      "height" : 57
    },
    "textPosition" : {
      "x" : 2928,
      "y" : 842
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 3133,
          "y" : 834
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 3133,
          "y" : 834
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 79523,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 79527,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 3136,
          "y" : 858
        },
        "to" : {
          "x" : 3216,
          "y" : 855
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 79527,
      "type" : "CATALYST",
      "segments" : [ {
        "from" : {
          "x" : 3093,
          "y" : 831
        },
        "to" : {
          "x" : 3233,
          "y" : 776
        }
      }, {
        "from" : {
          "x" : 3233,
          "y" : 776
        },
        "to" : {
          "x" : 3254,
          "y" : 842
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 3255,
          "y" : 846
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 3255,
          "y" : 846
        }
      }
    } ]
  }, {
    "id" : 79529,
    "reactomeId" : 9997033,
    "displayName" : "UBE2D1,2,3",
    "schemaClass" : "DefinedSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 3329,
      "y" : 780
    },
    "minX" : 3278,
    "maxX" : 3381,
    "minY" : 768,
    "maxY" : 855,
    "prop" : {
      "x" : 3278,
      "y" : 768,
      "width" : 103,
      "height" : 24
    },
    "textPosition" : {
      "x" : 3288,
      "y" : 769
    },
    "connectors" : [ {
      "edgeId" : 79527,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 3323,
          "y" : 798
        },
        "to" : {
          "x" : 3294,
          "y" : 855
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 3323,
          "y" : 806
        },
        "b" : {
          "x" : 3323,
          "y" : 798
        },
        "c" : {
          "x" : 3316,
          "y" : 802
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 3316,
          "y" : 802
        }
      }
    } ]
  }, {
    "id" : 79528,
    "reactomeId" : 9997035,
    "displayName" : "UBE2D1,2,3:Ubiquitin",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 3130,
      "y" : 923
    },
    "minX" : 3088,
    "maxX" : 3216,
    "minY" : 855,
    "maxY" : 941,
    "prop" : {
      "x" : 3088,
      "y" : 905,
      "width" : 84,
      "height" : 36
    },
    "textPosition" : {
      "x" : 3098,
      "y" : 892
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 3172,
          "y" : 905
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 3172,
          "y" : 905
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 79527,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 3152,
          "y" : 902
        },
        "to" : {
          "x" : 3216,
          "y" : 855
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 79531,
    "reactomeId" : 10084123,
    "displayName" : "RBX1:NEDD8-CUL2:EloB,C:VHL:COMMDs:CCDC22:DCUN1D1,2,4,5:UBXN7",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 3249,
      "y" : 979
    },
    "minX" : 3166,
    "maxX" : 3339,
    "minY" : 866,
    "maxY" : 1008,
    "prop" : {
      "x" : 3166,
      "y" : 951,
      "width" : 167,
      "height" : 57
    },
    "textPosition" : {
      "x" : 3171,
      "y" : 959
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 3333,
          "y" : 951
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 3333,
          "y" : 951
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 79560,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 79527,
      "type" : "INHIBITOR",
      "segments" : [ {
        "from" : {
          "x" : 3251,
          "y" : 948
        },
        "to" : {
          "x" : 3258,
          "y" : 866
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 3254,
          "y" : 866
        },
        "b" : {
          "x" : 3262,
          "y" : 866
        },
        "c" : {
          "x" : 3258,
          "y" : 866
        },
        "type" : "STOP",
        "centre" : {
          "x" : 3258,
          "y" : 866
        }
      }
    } ]
  }, {
    "id" : 79530,
    "reactomeId" : 10084134,
    "displayName" : "ub-hydroxyPro-HIF-alpha:VHL:EloB:EloC:NEDD8-CUL2:RBX1:COMMDs:CCDC22:DCUN1D1,2,4,5",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 3441,
      "y" : 863
    },
    "minX" : 3294,
    "maxX" : 3545,
    "minY" : 822,
    "maxY" : 899,
    "prop" : {
      "x" : 3343,
      "y" : 828,
      "width" : 196,
      "height" : 71
    },
    "textPosition" : {
      "x" : 3346,
      "y" : 836
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 3539,
          "y" : 828
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 3539,
          "y" : 828
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 79527,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 3340,
          "y" : 857
        },
        "to" : {
          "x" : 3294,
          "y" : 855
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 3333,
          "y" : 861
        },
        "b" : {
          "x" : 3340,
          "y" : 857
        },
        "c" : {
          "x" : 3333,
          "y" : 853
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 3333,
          "y" : 853
        }
      }
    }, {
      "edgeId" : 79547,
      "type" : "INPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 79533,
    "reactomeId" : 10084148,
    "displayName" : "NEDD8,UBD",
    "schemaClass" : "DefinedSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 361,
      "y" : 242
    },
    "minX" : 322,
    "maxX" : 475,
    "minY" : 203,
    "maxY" : 253,
    "prop" : {
      "x" : 322,
      "y" : 231,
      "width" : 79,
      "height" : 22
    },
    "textPosition" : {
      "x" : 334,
      "y" : 225
    },
    "connectors" : [ {
      "edgeId" : 79532,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 393,
          "y" : 225
        },
        "to" : {
          "x" : 475,
          "y" : 203
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 79535,
    "reactomeId" : 9985422,
    "displayName" : "26S proteasome",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 393,
      "y" : 120
    },
    "minX" : 342,
    "maxX" : 761,
    "minY" : 76,
    "maxY" : 203,
    "prop" : {
      "x" : 342,
      "y" : 109,
      "width" : 103,
      "height" : 22
    },
    "textPosition" : {
      "x" : 351,
      "y" : 96
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 445,
          "y" : 109
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 445,
          "y" : 109
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 79532,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 403,
          "y" : 134
        },
        "to" : {
          "x" : 475,
          "y" : 203
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 79537,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 448,
          "y" : 111
        },
        "to" : {
          "x" : 667,
          "y" : 76
        }
      }, {
        "from" : {
          "x" : 667,
          "y" : 76
        },
        "to" : {
          "x" : 761,
          "y" : 195
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 454,
          "y" : 106
        },
        "b" : {
          "x" : 448,
          "y" : 111
        },
        "c" : {
          "x" : 455,
          "y" : 114
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 455,
          "y" : 114
        }
      }
    } ]
  }, {
    "id" : 79534,
    "reactomeId" : 10084142,
    "displayName" : "Nub1",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 366,
      "y" : 171
    },
    "minX" : 334,
    "maxX" : 761,
    "minY" : 126,
    "maxY" : 203,
    "prop" : {
      "x" : 334,
      "y" : 157,
      "width" : 64,
      "height" : 29
    },
    "textPosition" : {
      "x" : 345,
      "y" : 161
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 398,
          "y" : 157
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 398,
          "y" : 157
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 79532,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 404,
          "y" : 180
        },
        "to" : {
          "x" : 475,
          "y" : 203
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 79537,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 404,
          "y" : 165
        },
        "to" : {
          "x" : 644,
          "y" : 126
        }
      }, {
        "from" : {
          "x" : 644,
          "y" : 126
        },
        "to" : {
          "x" : 761,
          "y" : 195
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 410,
          "y" : 160
        },
        "b" : {
          "x" : 404,
          "y" : 165
        },
        "c" : {
          "x" : 411,
          "y" : 168
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 411,
          "y" : 168
        }
      }
    } ]
  }, {
    "id" : 79536,
    "reactomeId" : 10084150,
    "displayName" : "NEDD8,UBD:NUB1:26S proteasome",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 613,
      "y" : 200
    },
    "minX" : 547,
    "maxX" : 686,
    "minY" : 173,
    "maxY" : 221,
    "prop" : {
      "x" : 547,
      "y" : 179,
      "width" : 133,
      "height" : 42
    },
    "textPosition" : {
      "x" : 552,
      "y" : 186
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 680,
          "y" : 179
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 680,
          "y" : 179
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 79532,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 79537,
      "type" : "INPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 79539,
    "reactomeId" : 10083624,
    "displayName" : "Dcun1d3",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 2040,
      "y" : 32
    },
    "minX" : 1972,
    "maxX" : 2177,
    "minY" : 7,
    "maxY" : 52,
    "prop" : {
      "x" : 1972,
      "y" : 13,
      "width" : 136,
      "height" : 39
    },
    "textPosition" : {
      "x" : 2008,
      "y" : 22
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 2108,
          "y" : 13
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 2108,
          "y" : 13
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 79538,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 2111,
          "y" : 34
        },
        "to" : {
          "x" : 2177,
          "y" : 37
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 79541,
    "reactomeId" : 10084121,
    "displayName" : "Ubxn7",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 2732,
      "y" : 983
    },
    "minX" : 2701,
    "maxX" : 2836,
    "minY" : 959,
    "maxY" : 1332,
    "prop" : {
      "x" : 2701,
      "y" : 971,
      "width" : 63,
      "height" : 24
    },
    "textPosition" : {
      "x" : 2709,
      "y" : 972
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 2764,
          "y" : 971
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 2764,
          "y" : 971
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 79555,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 2733,
          "y" : 998
        },
        "to" : {
          "x" : 2763,
          "y" : 1332
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 79560,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 2767,
          "y" : 974
        },
        "to" : {
          "x" : 2818,
          "y" : 959
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 79540,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 2745,
          "y" : 998
        },
        "to" : {
          "x" : 2836,
          "y" : 1079
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 79543,
    "reactomeId" : 10092022,
    "displayName" : "Ubxn7",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 3022,
      "y" : 1075
    },
    "minX" : 2977,
    "maxX" : 3074,
    "minY" : 1050,
    "maxY" : 1095,
    "prop" : {
      "x" : 2977,
      "y" : 1056,
      "width" : 91,
      "height" : 39
    },
    "textPosition" : {
      "x" : 2999,
      "y" : 1065
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 3068,
          "y" : 1056
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 3068,
          "y" : 1056
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 79540,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 79545,
      "type" : "INPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 79542,
    "reactomeId" : 9985374,
    "displayName" : "Ub",
    "schemaClass" : "DefinedSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 2828,
      "y" : 1015
    },
    "minX" : 2816,
    "maxX" : 2841,
    "minY" : 1004,
    "maxY" : 1079,
    "prop" : {
      "x" : 2816,
      "y" : 1004,
      "width" : 25,
      "height" : 22
    },
    "textPosition" : {
      "x" : 2816,
      "y" : 1004
    },
    "connectors" : [ {
      "edgeId" : 79540,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 2829,
          "y" : 1032
        },
        "to" : {
          "x" : 2836,
          "y" : 1079
        }
      } ],
      "stoichiometry" : {
        "value" : 3,
        "shape" : {
          "a" : {
            "x" : 2826,
            "y" : 1049
          },
          "b" : {
            "x" : 2838,
            "y" : 1061
          },
          "type" : "BOX",
          "empty" : true,
          "centre" : {
            "x" : 2832,
            "y" : 1055
          }
        }
      }
    }, {
      "edgeId" : 79545,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 79544,
    "reactomeId" : 10084125,
    "displayName" : "MUL1 dimer",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 2867,
      "y" : 1134
    },
    "minX" : 2825,
    "maxX" : 2988,
    "minY" : 964,
    "maxY" : 1150,
    "prop" : {
      "x" : 2825,
      "y" : 1119,
      "width" : 84,
      "height" : 31
    },
    "textPosition" : {
      "x" : 2827,
      "y" : 1129
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 2909,
          "y" : 1119
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 2909,
          "y" : 1119
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 79560,
      "type" : "INHIBITOR",
      "segments" : [ {
        "from" : {
          "x" : 2877,
          "y" : 1116
        },
        "to" : {
          "x" : 2985,
          "y" : 966
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 2982,
          "y" : 964
        },
        "b" : {
          "x" : 2988,
          "y" : 968
        },
        "c" : {
          "x" : 2985,
          "y" : 966
        },
        "type" : "STOP",
        "centre" : {
          "x" : 2985,
          "y" : 966
        }
      }
    }, {
      "edgeId" : 79540,
      "type" : "CATALYST",
      "segments" : [ {
        "from" : {
          "x" : 2867,
          "y" : 1116
        },
        "to" : {
          "x" : 2869,
          "y" : 1096
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 2869,
          "y" : 1092
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 2869,
          "y" : 1092
        }
      }
    } ]
  }, {
    "id" : 79546,
    "reactomeId" : 9985422,
    "displayName" : "26S proteasome",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 3254,
      "y" : 1106
    },
    "minX" : 3111,
    "maxX" : 3584,
    "minY" : 879,
    "maxY" : 1224,
    "prop" : {
      "x" : 3203,
      "y" : 1095,
      "width" : 103,
      "height" : 22
    },
    "textPosition" : {
      "x" : 3212,
      "y" : 1082
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 3306,
          "y" : 1095
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 3306,
          "y" : 1095
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 79564,
      "type" : "CATALYST",
      "segments" : [ {
        "from" : {
          "x" : 3255,
          "y" : 1120
        },
        "to" : {
          "x" : 3265,
          "y" : 1216
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 3266,
          "y" : 1220
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 3266,
          "y" : 1220
        }
      }
    }, {
      "edgeId" : 79545,
      "type" : "CATALYST",
      "segments" : [ {
        "from" : {
          "x" : 3233,
          "y" : 1092
        },
        "to" : {
          "x" : 3118,
          "y" : 1032
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 3115,
          "y" : 1031
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 3115,
          "y" : 1031
        }
      }
    }, {
      "edgeId" : 79547,
      "type" : "CATALYST",
      "segments" : [ {
        "from" : {
          "x" : 3270,
          "y" : 1092
        },
        "to" : {
          "x" : 3577,
          "y" : 885
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 3580,
          "y" : 883
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 3580,
          "y" : 883
        }
      }
    } ]
  }, {
    "id" : 79548,
    "reactomeId" : 9985374,
    "displayName" : "Ub",
    "schemaClass" : "DefinedSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 3681,
      "y" : 917
    },
    "minX" : 3627,
    "maxX" : 3694,
    "minY" : 873,
    "maxY" : 928,
    "prop" : {
      "x" : 3669,
      "y" : 906,
      "width" : 25,
      "height" : 22
    },
    "textPosition" : {
      "x" : 3669,
      "y" : 906
    },
    "connectors" : [ {
      "edgeId" : 79547,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 3663,
          "y" : 906
        },
        "to" : {
          "x" : 3627,
          "y" : 873
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 3655,
          "y" : 904
        },
        "b" : {
          "x" : 3663,
          "y" : 906
        },
        "c" : {
          "x" : 3661,
          "y" : 898
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 3661,
          "y" : 898
        }
      }
    } ]
  }, {
    "id" : 79551,
    "reactomeId" : 9985374,
    "displayName" : "Ub",
    "schemaClass" : "DefinedSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 2993,
      "y" : 1295
    },
    "minX" : 2981,
    "maxX" : 3019,
    "minY" : 1284,
    "maxY" : 1415,
    "prop" : {
      "x" : 2981,
      "y" : 1284,
      "width" : 25,
      "height" : 22
    },
    "textPosition" : {
      "x" : 2981,
      "y" : 1284
    },
    "connectors" : [ {
      "edgeId" : 79564,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 79549,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 2995,
          "y" : 1312
        },
        "to" : {
          "x" : 3019,
          "y" : 1415
        }
      } ],
      "stoichiometry" : {
        "value" : 3,
        "shape" : {
          "a" : {
            "x" : 3001,
            "y" : 1357
          },
          "b" : {
            "x" : 3013,
            "y" : 1369
          },
          "type" : "BOX",
          "empty" : true,
          "centre" : {
            "x" : 3007,
            "y" : 1363
          }
        }
      }
    } ]
  }, {
    "id" : 79550,
    "reactomeId" : 10091352,
    "displayName" : "KEAP1:NEDD8-CUL3:RBX1:NFE2L2",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 2909,
      "y" : 1408
    },
    "minX" : 2848,
    "maxX" : 3058,
    "minY" : 1380,
    "maxY" : 1459,
    "prop" : {
      "x" : 2848,
      "y" : 1386,
      "width" : 123,
      "height" : 44
    },
    "textPosition" : {
      "x" : 2860,
      "y" : 1381
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 2971,
          "y" : 1386
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 2971,
          "y" : 1386
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 79549,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 2974,
          "y" : 1411
        },
        "to" : {
          "x" : 3019,
          "y" : 1415
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 79549,
      "type" : "CATALYST",
      "segments" : [ {
        "from" : {
          "x" : 2954,
          "y" : 1433
        },
        "to" : {
          "x" : 3015,
          "y" : 1459
        }
      }, {
        "from" : {
          "x" : 3015,
          "y" : 1459
        },
        "to" : {
          "x" : 3051,
          "y" : 1428
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 3054,
          "y" : 1425
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 3054,
          "y" : 1425
        }
      }
    } ]
  }, {
    "id" : 79553,
    "reactomeId" : 1250243,
    "displayName" : "ROS",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 3056,
      "y" : 1361
    },
    "minX" : 3036,
    "maxX" : 3077,
    "minY" : 1345,
    "maxY" : 1409,
    "prop" : {
      "x" : 3036,
      "y" : 1346,
      "width" : 40,
      "height" : 31
    },
    "textPosition" : {
      "x" : 3039,
      "y" : 1351
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 3071,
          "y" : 1351
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 3071,
          "y" : 1351
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 79549,
      "type" : "INHIBITOR",
      "segments" : [ {
        "from" : {
          "x" : 3057,
          "y" : 1380
        },
        "to" : {
          "x" : 3062,
          "y" : 1408
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 3058,
          "y" : 1409
        },
        "b" : {
          "x" : 3066,
          "y" : 1407
        },
        "c" : {
          "x" : 3062,
          "y" : 1408
        },
        "type" : "STOP",
        "centre" : {
          "x" : 3062,
          "y" : 1408
        }
      }
    } ]
  }, {
    "id" : 79552,
    "reactomeId" : 10092029,
    "displayName" : "ub-NFE2L2:KEAP1:NEDD8-CUL3:RBX1",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 3284,
      "y" : 1415
    },
    "minX" : 3223,
    "maxX" : 3352,
    "minY" : 1329,
    "maxY" : 1434,
    "prop" : {
      "x" : 3223,
      "y" : 1397,
      "width" : 123,
      "height" : 37
    },
    "textPosition" : {
      "x" : 3224,
      "y" : 1399
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 3346,
          "y" : 1397
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 3346,
          "y" : 1397
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 79558,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 3277,
          "y" : 1394
        },
        "to" : {
          "x" : 3252,
          "y" : 1329
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 79549,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 79554,
    "reactomeId" : 10091354,
    "displayName" : "NFE2L2 inducers:KEAP1:CUL3:RBX1:NFE2L2",
    "schemaClass" : "Complex",
    "renderableClass" : "ComplexDrug",
    "position" : {
      "x" : 3160,
      "y" : 1483
    },
    "minX" : 3069,
    "maxX" : 3226,
    "minY" : 1419,
    "maxY" : 1509,
    "prop" : {
      "x" : 3100,
      "y" : 1458,
      "width" : 120,
      "height" : 51
    },
    "textPosition" : {
      "x" : 3102,
      "y" : 1460
    },
    "bgColor" : {
      "r" : 184,
      "g" : 154,
      "b" : 230
    },
    "fgColor" : {
      "r" : 161,
      "g" : 1,
      "b" : 2
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 3220,
          "y" : 1458
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 3220,
          "y" : 1458
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 79549,
      "type" : "INHIBITOR",
      "segments" : [ {
        "from" : {
          "x" : 3122,
          "y" : 1455
        },
        "to" : {
          "x" : 3071,
          "y" : 1422
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 3069,
          "y" : 1425
        },
        "b" : {
          "x" : 3073,
          "y" : 1419
        },
        "c" : {
          "x" : 3071,
          "y" : 1422
        },
        "type" : "STOP",
        "centre" : {
          "x" : 3071,
          "y" : 1422
        }
      }
    } ]
  }, {
    "id" : 79557,
    "reactomeId" : 10092041,
    "displayName" : "UBXN7:NPLOC4:UBF1:VCP hexamer",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 3140,
      "y" : 1328
    },
    "minX" : 3080,
    "maxX" : 3582,
    "minY" : 1277,
    "maxY" : 1354,
    "prop" : {
      "x" : 3080,
      "y" : 1310,
      "width" : 120,
      "height" : 37
    },
    "textPosition" : {
      "x" : 3087,
      "y" : 1298
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 3200,
          "y" : 1310
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 3200,
          "y" : 1310
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 79555,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 79558,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 3203,
          "y" : 1328
        },
        "to" : {
          "x" : 3252,
          "y" : 1329
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 79561,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 3188,
          "y" : 1307
        },
        "to" : {
          "x" : 3273,
          "y" : 1277
        }
      }, {
        "from" : {
          "x" : 3273,
          "y" : 1277
        },
        "to" : {
          "x" : 3474,
          "y" : 1280
        }
      }, {
        "from" : {
          "x" : 3474,
          "y" : 1280
        },
        "to" : {
          "x" : 3582,
          "y" : 1354
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 3193,
          "y" : 1301
        },
        "b" : {
          "x" : 3188,
          "y" : 1307
        },
        "c" : {
          "x" : 3196,
          "y" : 1308
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 3196,
          "y" : 1308
        }
      }
    } ]
  }, {
    "id" : 79556,
    "reactomeId" : 10092135,
    "displayName" : "NPLOC4:UFD1:VCP hexamer",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 2619,
      "y" : 1334
    },
    "minX" : 2559,
    "maxX" : 2763,
    "minY" : 1310,
    "maxY" : 1353,
    "prop" : {
      "x" : 2559,
      "y" : 1316,
      "width" : 120,
      "height" : 37
    },
    "textPosition" : {
      "x" : 2570,
      "y" : 1318
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 2679,
          "y" : 1316
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 2679,
          "y" : 1316
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 79555,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 2682,
          "y" : 1333
        },
        "to" : {
          "x" : 2763,
          "y" : 1332
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 79559,
    "reactomeId" : 10092043,
    "displayName" : "ub-NFE2L2:KEAP1:NEDD8-CUL3:RBX1:UBXN7:UBF1:NPLOC4:VCP hexamer",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 3427,
      "y" : 1332
    },
    "minX" : 3364,
    "maxX" : 3497,
    "minY" : 1287,
    "maxY" : 1372,
    "prop" : {
      "x" : 3364,
      "y" : 1293,
      "width" : 127,
      "height" : 79
    },
    "textPosition" : {
      "x" : 3365,
      "y" : 1295
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 3491,
          "y" : 1293
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 3491,
          "y" : 1293
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 79558,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 79561,
      "type" : "INPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 79563,
    "reactomeId" : 10091350,
    "displayName" : "KEAP1:NEDD8-CUL3:RBX1",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 2697,
      "y" : 1562
    },
    "minX" : 2630,
    "maxX" : 3585,
    "minY" : 1354,
    "maxY" : 1580,
    "prop" : {
      "x" : 2630,
      "y" : 1544,
      "width" : 135,
      "height" : 36
    },
    "textPosition" : {
      "x" : 2631,
      "y" : 1545
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 2765,
          "y" : 1544
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 2765,
          "y" : 1544
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 79561,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 2768,
          "y" : 1561
        },
        "to" : {
          "x" : 3585,
          "y" : 1553
        }
      }, {
        "from" : {
          "x" : 3585,
          "y" : 1553
        },
        "to" : {
          "x" : 3582,
          "y" : 1354
        }
      } ],
      "stoichiometry" : {
        "value" : 2,
        "shape" : {
          "a" : {
            "x" : 3170,
            "y" : 1551
          },
          "b" : {
            "x" : 3182,
            "y" : 1563
          },
          "type" : "BOX",
          "empty" : true,
          "centre" : {
            "x" : 3176,
            "y" : 1557
          }
        }
      },
      "endShape" : {
        "a" : {
          "x" : 2775,
          "y" : 1557
        },
        "b" : {
          "x" : 2768,
          "y" : 1561
        },
        "c" : {
          "x" : 2775,
          "y" : 1565
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 2775,
          "y" : 1565
        }
      }
    } ]
  }, {
    "id" : 79562,
    "reactomeId" : 10080488,
    "displayName" : "Nfe2l2",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 3679,
      "y" : 1339
    },
    "minX" : 3582,
    "maxX" : 3723,
    "minY" : 1322,
    "maxY" : 1354,
    "prop" : {
      "x" : 3642,
      "y" : 1328,
      "width" : 75,
      "height" : 23
    },
    "textPosition" : {
      "x" : 3655,
      "y" : 1329
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 3717,
          "y" : 1328
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 3717,
          "y" : 1328
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 79561,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 3639,
          "y" : 1344
        },
        "to" : {
          "x" : 3582,
          "y" : 1354
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 3633,
          "y" : 1349
        },
        "b" : {
          "x" : 3639,
          "y" : 1344
        },
        "c" : {
          "x" : 3631,
          "y" : 1341
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 3631,
          "y" : 1341
        }
      }
    }, {
      "edgeId" : 79564,
      "type" : "INPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 79580,
    "reactomeId" : 10091348,
    "displayName" : "Nfe2l2",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 2684,
      "y" : 1429
    },
    "minX" : 2646,
    "maxX" : 2729,
    "minY" : 1410,
    "maxY" : 1442,
    "prop" : {
      "x" : 2646,
      "y" : 1416,
      "width" : 77,
      "height" : 26
    },
    "textPosition" : {
      "x" : 2660,
      "y" : 1418
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 2723,
          "y" : 1416
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 2723,
          "y" : 1416
        }
      }
    },
    "connectors" : [ ]
  }, {
    "id" : 79582,
    "reactomeId" : 10101215,
    "displayName" : "KEAP1-NFE2L2 pathway",
    "schemaClass" : "Pathway",
    "renderableClass" : "EncapsulatedNode",
    "position" : {
      "x" : 2600,
      "y" : 1489
    },
    "minX" : 2533,
    "maxX" : 2667,
    "minY" : 1460,
    "maxY" : 1518,
    "prop" : {
      "x" : 2533,
      "y" : 1460,
      "width" : 134,
      "height" : 58
    },
    "textPosition" : {
      "x" : 2545,
      "y" : 1467
    },
    "connectors" : [ ]
  }, {
    "id" : 79461,
    "reactomeId" : 10062713,
    "displayName" : "UCHL3,SENP8:NEDD8(1-88)",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 117,
      "y" : 472
    },
    "minX" : 67,
    "maxX" : 218,
    "minY" : 434,
    "maxY" : 497,
    "prop" : {
      "x" : 67,
      "y" : 447,
      "width" : 101,
      "height" : 50
    },
    "textPosition" : {
      "x" : 69,
      "y" : 462
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 168,
          "y" : 447
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 168,
          "y" : 447
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 79459,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 171,
          "y" : 477
        },
        "to" : {
          "x" : 196,
          "y" : 480
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 79459,
      "type" : "CATALYST",
      "segments" : [ {
        "from" : {
          "x" : 156,
          "y" : 444
        },
        "to" : {
          "x" : 177,
          "y" : 434
        }
      }, {
        "from" : {
          "x" : 177,
          "y" : 434
        },
        "to" : {
          "x" : 211,
          "y" : 467
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 214,
          "y" : 470
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 214,
          "y" : 470
        }
      }
    } ]
  }, {
    "id" : 79460,
    "reactomeId" : 29356,
    "displayName" : "H2O",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 131,
      "y" : 531
    },
    "minX" : 105,
    "maxX" : 196,
    "minY" : 480,
    "maxY" : 549,
    "prop" : {
      "x" : 105,
      "y" : 514,
      "width" : 53,
      "height" : 35
    },
    "textPosition" : {
      "x" : 114,
      "y" : 521
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 153,
          "y" : 519
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 153,
          "y" : 519
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 79459,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 153,
          "y" : 511
        },
        "to" : {
          "x" : 196,
          "y" : 480
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ],
    "trivial" : true
  }, {
    "id" : 79463,
    "reactomeId" : 10062719,
    "displayName" : "Nedd8",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 289,
      "y" : 527
    },
    "minX" : 237,
    "maxX" : 348,
    "minY" : 478,
    "maxY" : 545,
    "prop" : {
      "x" : 237,
      "y" : 509,
      "width" : 105,
      "height" : 36
    },
    "textPosition" : {
      "x" : 265,
      "y" : 516
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 342,
          "y" : 509
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 342,
          "y" : 509
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 79459,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 273,
          "y" : 506
        },
        "to" : {
          "x" : 247,
          "y" : 478
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 265,
          "y" : 504
        },
        "b" : {
          "x" : 273,
          "y" : 506
        },
        "c" : {
          "x" : 271,
          "y" : 498
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 271,
          "y" : 498
        }
      }
    } ]
  }, {
    "id" : 79462,
    "reactomeId" : 10062717,
    "displayName" : "UCHL3,SENP8:NEDD8",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 356,
      "y" : 478
    },
    "minX" : 247,
    "maxX" : 419,
    "minY" : 454,
    "maxY" : 496,
    "prop" : {
      "x" : 300,
      "y" : 460,
      "width" : 113,
      "height" : 36
    },
    "textPosition" : {
      "x" : 308,
      "y" : 461
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 413,
          "y" : 460
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 413,
          "y" : 460
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 79459,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 297,
          "y" : 478
        },
        "to" : {
          "x" : 247,
          "y" : 478
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 290,
          "y" : 482
        },
        "b" : {
          "x" : 297,
          "y" : 478
        },
        "c" : {
          "x" : 290,
          "y" : 474
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 290,
          "y" : 474
        }
      }
    }, {
      "edgeId" : 79464,
      "type" : "INPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 79465,
    "reactomeId" : 10062709,
    "displayName" : "UCHL3,SENP8",
    "schemaClass" : "DefinedSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 491,
      "y" : 517
    },
    "minX" : 435,
    "maxX" : 548,
    "minY" : 485,
    "maxY" : 530,
    "prop" : {
      "x" : 435,
      "y" : 504,
      "width" : 113,
      "height" : 26
    },
    "textPosition" : {
      "x" : 445,
      "y" : 506
    },
    "connectors" : [ {
      "edgeId" : 79464,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 478,
          "y" : 498
        },
        "to" : {
          "x" : 461,
          "y" : 485
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 470,
          "y" : 497
        },
        "b" : {
          "x" : 478,
          "y" : 498
        },
        "c" : {
          "x" : 475,
          "y" : 491
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 475,
          "y" : 491
        }
      }
    } ]
  }, {
    "id" : 79466,
    "reactomeId" : 10062715,
    "displayName" : "Nedd8",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 513,
      "y" : 410
    },
    "minX" : 461,
    "maxX" : 2951,
    "minY" : 164,
    "maxY" : 667,
    "prop" : {
      "x" : 488,
      "y" : 399,
      "width" : 50,
      "height" : 22
    },
    "textPosition" : {
      "x" : 488,
      "y" : 399
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 538,
          "y" : 399
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 538,
          "y" : 399
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 79515,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 536,
          "y" : 396
        },
        "to" : {
          "x" : 1008,
          "y" : 174
        }
      }, {
        "from" : {
          "x" : 1008,
          "y" : 174
        },
        "to" : {
          "x" : 2787,
          "y" : 164
        }
      }, {
        "from" : {
          "x" : 2787,
          "y" : 164
        },
        "to" : {
          "x" : 2951,
          "y" : 667
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 541,
          "y" : 389
        },
        "b" : {
          "x" : 536,
          "y" : 396
        },
        "c" : {
          "x" : 544,
          "y" : 397
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 544,
          "y" : 397
        }
      }
    }, {
      "edgeId" : 79464,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 505,
          "y" : 424
        },
        "to" : {
          "x" : 461,
          "y" : 485
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 504,
          "y" : 432
        },
        "b" : {
          "x" : 505,
          "y" : 424
        },
        "c" : {
          "x" : 498,
          "y" : 427
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 498,
          "y" : 427
        }
      }
    } ]
  }, {
    "id" : 79469,
    "reactomeId" : 10082785,
    "displayName" : "NEDD8-AcM-UBE2F",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 1440,
      "y" : 405
    },
    "minX" : 1399,
    "maxX" : 1526,
    "minY" : 378,
    "maxY" : 426,
    "prop" : {
      "x" : 1399,
      "y" : 384,
      "width" : 82,
      "height" : 42
    },
    "textPosition" : {
      "x" : 1401,
      "y" : 391
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1481,
          "y" : 384
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1481,
          "y" : 384
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 79467,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1484,
          "y" : 405
        },
        "to" : {
          "x" : 1526,
          "y" : 407
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 79468,
    "reactomeId" : 10082884,
    "displayName" : "DCUN1Ds",
    "schemaClass" : "CandidateSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 1438,
      "y" : 536
    },
    "minX" : 1389,
    "maxX" : 1615,
    "minY" : 407,
    "maxY" : 669,
    "prop" : {
      "x" : 1389,
      "y" : 525,
      "width" : 99,
      "height" : 23
    },
    "textPosition" : {
      "x" : 1405,
      "y" : 526
    },
    "connectors" : [ {
      "edgeId" : 79467,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1445,
          "y" : 519
        },
        "to" : {
          "x" : 1526,
          "y" : 407
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 79475,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1453,
          "y" : 554
        },
        "to" : {
          "x" : 1615,
          "y" : 669
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 79471,
    "reactomeId" : 10082886,
    "displayName" : "NEDD8-AcM-UBE2F:CRL5 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 1682,
      "y" : 408
    },
    "minX" : 1608,
    "maxX" : 1796,
    "minY" : 341,
    "maxY" : 441,
    "prop" : {
      "x" : 1608,
      "y" : 375,
      "width" : 148,
      "height" : 66
    },
    "textPosition" : {
      "x" : 1618,
      "y" : 378
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1756,
          "y" : 375
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1756,
          "y" : 375
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 79467,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 79472,
      "type" : "INPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 79472,
      "type" : "CATALYST",
      "segments" : [ {
        "from" : {
          "x" : 1717,
          "y" : 372
        },
        "to" : {
          "x" : 1754,
          "y" : 341
        }
      }, {
        "from" : {
          "x" : 1754,
          "y" : 341
        },
        "to" : {
          "x" : 1790,
          "y" : 397
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 1792,
          "y" : 400
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1792,
          "y" : 400
        }
      }
    } ]
  }, {
    "id" : 79470,
    "reactomeId" : 10082862,
    "displayName" : "CRL5 E3 ubiquitin ligase:COMMDs:CCDC22",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 1342,
      "y" : 259
    },
    "minX" : 1270,
    "maxX" : 1526,
    "minY" : 228,
    "maxY" : 407,
    "prop" : {
      "x" : 1270,
      "y" : 234,
      "width" : 145,
      "height" : 50
    },
    "textPosition" : {
      "x" : 1282,
      "y" : 235
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1415,
          "y" : 234
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1415,
          "y" : 234
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 79467,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1373,
          "y" : 287
        },
        "to" : {
          "x" : 1526,
          "y" : 407
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 79473,
    "reactomeId" : 10082895,
    "displayName" : "NEDD8-CRL5 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 1946,
      "y" : 400
    },
    "minX" : 1834,
    "maxX" : 2031,
    "minY" : 370,
    "maxY" : 425,
    "prop" : {
      "x" : 1868,
      "y" : 376,
      "width" : 157,
      "height" : 49
    },
    "textPosition" : {
      "x" : 1887,
      "y" : 362
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 2025,
          "y" : 376
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 2025,
          "y" : 376
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 79472,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 1865,
          "y" : 407
        },
        "to" : {
          "x" : 1834,
          "y" : 410
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 1858,
          "y" : 412
        },
        "b" : {
          "x" : 1865,
          "y" : 407
        },
        "c" : {
          "x" : 1858,
          "y" : 404
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 1858,
          "y" : 404
        }
      }
    } ]
  }, {
    "id" : 79474,
    "reactomeId" : 10082750,
    "displayName" : "Ube2f",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 1047,
      "y" : 334
    },
    "minX" : 1009,
    "maxX" : 1854,
    "minY" : 221,
    "maxY" : 410,
    "prop" : {
      "x" : 1009,
      "y" : 321,
      "width" : 77,
      "height" : 27
    },
    "textPosition" : {
      "x" : 1025,
      "y" : 324
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1086,
          "y" : 321
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1086,
          "y" : 321
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 79472,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 1059,
          "y" : 318
        },
        "to" : {
          "x" : 1143,
          "y" : 227
        }
      }, {
        "from" : {
          "x" : 1143,
          "y" : 227
        },
        "to" : {
          "x" : 1854,
          "y" : 221
        }
      }, {
        "from" : {
          "x" : 1854,
          "y" : 221
        },
        "to" : {
          "x" : 1834,
          "y" : 410
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 1061,
          "y" : 310
        },
        "b" : {
          "x" : 1059,
          "y" : 318
        },
        "c" : {
          "x" : 1067,
          "y" : 316
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 1067,
          "y" : 316
        }
      }
    } ]
  }, {
    "id" : 79477,
    "reactomeId" : 10083611,
    "displayName" : "CRL1 E3 ubiquitin ligase:COMMDs:CCDC22",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 1599,
      "y" : 558
    },
    "minX" : 1522,
    "maxX" : 2177,
    "minY" : 37,
    "maxY" : 669,
    "prop" : {
      "x" : 1522,
      "y" : 531,
      "width" : 154,
      "height" : 55
    },
    "textPosition" : {
      "x" : 1539,
      "y" : 537
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1676,
          "y" : 531
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1676,
          "y" : 531
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 79475,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1602,
          "y" : 589
        },
        "to" : {
          "x" : 1615,
          "y" : 669
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 79538,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1679,
          "y" : 545
        },
        "to" : {
          "x" : 2074,
          "y" : 479
        }
      }, {
        "from" : {
          "x" : 2074,
          "y" : 479
        },
        "to" : {
          "x" : 2177,
          "y" : 37
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 79476,
    "reactomeId" : 10050634,
    "displayName" : "NEDD8-AcM-UBE2M",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 1457,
      "y" : 666
    },
    "minX" : 1415,
    "maxX" : 1739,
    "minY" : 638,
    "maxY" : 998,
    "prop" : {
      "x" : 1415,
      "y" : 644,
      "width" : 85,
      "height" : 45
    },
    "textPosition" : {
      "x" : 1415,
      "y" : 654
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1500,
          "y" : 644
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1500,
          "y" : 644
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 79489,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1472,
          "y" : 692
        },
        "to" : {
          "x" : 1693,
          "y" : 998
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 79475,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1503,
          "y" : 666
        },
        "to" : {
          "x" : 1615,
          "y" : 669
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 79483,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1494,
          "y" : 692
        },
        "to" : {
          "x" : 1739,
          "y" : 835
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 79478,
    "reactomeId" : 10083613,
    "displayName" : "NEDD8-AcM-UBE2M:CRL1 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 1761,
      "y" : 665
    },
    "minX" : 1694,
    "maxX" : 1891,
    "minY" : 622,
    "maxY" : 698,
    "prop" : {
      "x" : 1694,
      "y" : 633,
      "width" : 135,
      "height" : 65
    },
    "textPosition" : {
      "x" : 1696,
      "y" : 635
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1829,
          "y" : 633
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1829,
          "y" : 633
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 79475,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 79479,
      "type" : "INPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 79479,
      "type" : "CATALYST",
      "segments" : [ {
        "from" : {
          "x" : 1817,
          "y" : 630
        },
        "to" : {
          "x" : 1836,
          "y" : 622
        }
      }, {
        "from" : {
          "x" : 1836,
          "y" : 622
        },
        "to" : {
          "x" : 1884,
          "y" : 671
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 1887,
          "y" : 674
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1887,
          "y" : 674
        }
      }
    } ]
  }, {
    "id" : 79481,
    "reactomeId" : 10083620,
    "displayName" : "NEDD8-CRL1 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 2037,
      "y" : 666
    },
    "minX" : 1937,
    "maxX" : 2102,
    "minY" : 626,
    "maxY" : 701,
    "prop" : {
      "x" : 1979,
      "y" : 632,
      "width" : 117,
      "height" : 69
    },
    "textPosition" : {
      "x" : 1983,
      "y" : 624
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 2096,
          "y" : 632
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 2096,
          "y" : 632
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 79479,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 1976,
          "y" : 678
        },
        "to" : {
          "x" : 1937,
          "y" : 688
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 1970,
          "y" : 684
        },
        "b" : {
          "x" : 1976,
          "y" : 678
        },
        "c" : {
          "x" : 1968,
          "y" : 676
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 1968,
          "y" : 676
        }
      }
    } ]
  }, {
    "id" : 79480,
    "reactomeId" : 10050636,
    "displayName" : "Ube2m",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 885,
      "y" : 710
    },
    "minX" : 845,
    "maxX" : 2093,
    "minY" : 688,
    "maxY" : 1105,
    "prop" : {
      "x" : 845,
      "y" : 696,
      "width" : 81,
      "height" : 28
    },
    "textPosition" : {
      "x" : 859,
      "y" : 699
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 926,
          "y" : 696
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 926,
          "y" : 696
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 79492,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 896,
          "y" : 727
        },
        "to" : {
          "x" : 1210,
          "y" : 1105
        }
      }, {
        "from" : {
          "x" : 1210,
          "y" : 1105
        },
        "to" : {
          "x" : 2093,
          "y" : 1095
        }
      }, {
        "from" : {
          "x" : 2093,
          "y" : 1095
        },
        "to" : {
          "x" : 2081,
          "y" : 1009
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 904,
          "y" : 730
        },
        "b" : {
          "x" : 896,
          "y" : 727
        },
        "c" : {
          "x" : 897,
          "y" : 735
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 897,
          "y" : 735
        }
      }
    }, {
      "edgeId" : 79479,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 929,
          "y" : 713
        },
        "to" : {
          "x" : 1427,
          "y" : 758
        }
      }, {
        "from" : {
          "x" : 1427,
          "y" : 758
        },
        "to" : {
          "x" : 1881,
          "y" : 744
        }
      }, {
        "from" : {
          "x" : 1881,
          "y" : 744
        },
        "to" : {
          "x" : 1937,
          "y" : 688
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 936,
          "y" : 710
        },
        "b" : {
          "x" : 929,
          "y" : 713
        },
        "c" : {
          "x" : 936,
          "y" : 718
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 936,
          "y" : 718
        }
      }
    }, {
      "edgeId" : 79487,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 929,
          "y" : 722
        },
        "to" : {
          "x" : 1453,
          "y" : 886
        }
      }, {
        "from" : {
          "x" : 1453,
          "y" : 886
        },
        "to" : {
          "x" : 2084,
          "y" : 878
        }
      }, {
        "from" : {
          "x" : 2084,
          "y" : 878
        },
        "to" : {
          "x" : 2084,
          "y" : 825
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 937,
          "y" : 720
        },
        "b" : {
          "x" : 929,
          "y" : 722
        },
        "c" : {
          "x" : 934,
          "y" : 728
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 934,
          "y" : 728
        }
      }
    } ]
  }, {
    "id" : 79482,
    "reactomeId" : 10083626,
    "displayName" : "CRL1 E3 ubiquitin ligase complex:MyrG-DCUN1D3",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 2392,
      "y" : 36
    },
    "minX" : 1900,
    "maxX" : 2483,
    "minY" : 0,
    "maxY" : 680,
    "prop" : {
      "x" : 2307,
      "y" : 6,
      "width" : 170,
      "height" : 61
    },
    "textPosition" : {
      "x" : 2311,
      "y" : 32
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 2477,
          "y" : 6
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 2477,
          "y" : 6
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 79538,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 79479,
      "type" : "INHIBITOR",
      "segments" : [ {
        "from" : {
          "x" : 2374,
          "y" : 70
        },
        "to" : {
          "x" : 2140,
          "y" : 488
        }
      }, {
        "from" : {
          "x" : 2140,
          "y" : 488
        },
        "to" : {
          "x" : 1902,
          "y" : 677
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 1900,
          "y" : 674
        },
        "b" : {
          "x" : 1904,
          "y" : 680
        },
        "c" : {
          "x" : 1902,
          "y" : 677
        },
        "type" : "STOP",
        "centre" : {
          "x" : 1902,
          "y" : 677
        }
      }
    } ]
  }, {
    "id" : 79485,
    "reactomeId" : 10083649,
    "displayName" : "CRL2 E3 ubiquitin ligase:COMMDs:CCDC22",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 1469,
      "y" : 845
    },
    "minX" : 1411,
    "maxX" : 1739,
    "minY" : 815,
    "maxY" : 870,
    "prop" : {
      "x" : 1411,
      "y" : 821,
      "width" : 117,
      "height" : 49
    },
    "textPosition" : {
      "x" : 1410,
      "y" : 821
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1528,
          "y" : 821
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1528,
          "y" : 821
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 79483,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1531,
          "y" : 842
        },
        "to" : {
          "x" : 1739,
          "y" : 835
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 79484,
    "reactomeId" : 10083651,
    "displayName" : "DCUN1D1,2,4,5",
    "schemaClass" : "CandidateSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 1499,
      "y" : 979
    },
    "minX" : 1432,
    "maxX" : 1739,
    "minY" : 835,
    "maxY" : 998,
    "prop" : {
      "x" : 1432,
      "y" : 968,
      "width" : 135,
      "height" : 22
    },
    "textPosition" : {
      "x" : 1447,
      "y" : 968
    },
    "connectors" : [ {
      "edgeId" : 79489,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1573,
          "y" : 985
        },
        "to" : {
          "x" : 1693,
          "y" : 998
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 79483,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1517,
          "y" : 962
        },
        "to" : {
          "x" : 1739,
          "y" : 835
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 79486,
    "reactomeId" : 10083653,
    "displayName" : "NEDD8-AcM-UBE2M:CRL2 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 1883,
      "y" : 830
    },
    "minX" : 1804,
    "maxX" : 2045,
    "minY" : 781,
    "maxY" : 862,
    "prop" : {
      "x" : 1804,
      "y" : 798,
      "width" : 159,
      "height" : 64
    },
    "textPosition" : {
      "x" : 1804,
      "y" : 799
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1963,
          "y" : 798
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1963,
          "y" : 798
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 79483,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 79487,
      "type" : "INPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 79487,
      "type" : "CATALYST",
      "segments" : [ {
        "from" : {
          "x" : 1966,
          "y" : 798
        },
        "to" : {
          "x" : 2006,
          "y" : 781
        }
      }, {
        "from" : {
          "x" : 2006,
          "y" : 781
        },
        "to" : {
          "x" : 2038,
          "y" : 814
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 2041,
          "y" : 816
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 2041,
          "y" : 816
        }
      }
    } ]
  } ],
  "edges" : [ {
    "id" : 79489,
    "reactomeId" : 10083671,
    "displayName" : "NEDD8:AcM-UBE2M binds CRL3 E3 ubiquitin ligase complex",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 1727,
      "y" : 997
    },
    "minX" : 1693,
    "maxX" : 1753,
    "minY" : 991,
    "maxY" : 1003,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 1693,
        "y" : 998
      },
      "to" : {
        "x" : 1727,
        "y" : 997
      }
    }, {
      "from" : {
        "x" : 1727,
        "y" : 997
      },
      "to" : {
        "x" : 1753,
        "y" : 997
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 1746,
        "y" : 1001
      },
      "b" : {
        "x" : 1753,
        "y" : 997
      },
      "c" : {
        "x" : 1746,
        "y" : 993
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 1746,
        "y" : 993
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 1727,
        "y" : 997
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 1727,
        "y" : 997
      }
    },
    "inputs" : [ {
      "id" : 79476,
      "points" : [ {
        "x" : 1472,
        "y" : 692
      } ]
    }, {
      "id" : 79484,
      "points" : [ {
        "x" : 1573,
        "y" : 985
      } ]
    }, {
      "id" : 79490,
      "points" : [ {
        "x" : 1456,
        "y" : 1040
      } ]
    } ],
    "outputs" : [ {
      "id" : 79491
    } ]
  }, {
    "id" : 79555,
    "reactomeId" : 10092137,
    "displayName" : "UBXN7 binds VCP hexamer:UBF1:NPLOC4",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 2930,
      "y" : 1333
    },
    "minX" : 2763,
    "maxX" : 3077,
    "minY" : 1327,
    "maxY" : 1339,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 2763,
        "y" : 1332
      },
      "to" : {
        "x" : 2930,
        "y" : 1333
      }
    }, {
      "from" : {
        "x" : 2930,
        "y" : 1333
      },
      "to" : {
        "x" : 3077,
        "y" : 1329
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 3070,
        "y" : 1333
      },
      "b" : {
        "x" : 3077,
        "y" : 1329
      },
      "c" : {
        "x" : 3070,
        "y" : 1325
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 3070,
        "y" : 1325
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 2930,
        "y" : 1333
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 2930,
        "y" : 1333
      }
    },
    "inputs" : [ {
      "id" : 79556,
      "points" : [ {
        "x" : 2682,
        "y" : 1333
      } ]
    }, {
      "id" : 79541,
      "points" : [ {
        "x" : 2733,
        "y" : 998
      } ]
    } ],
    "outputs" : [ {
      "id" : 79557
    } ]
  }, {
    "id" : 79492,
    "reactomeId" : 10083681,
    "displayName" : "AcM-UBE2M transfers NEDD8 to CRL3 E3 ubiquitin ligase complex",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 2048,
      "y" : 1009
    },
    "minX" : 1915,
    "maxX" : 2081,
    "minY" : 1002,
    "maxY" : 1015,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 1915,
        "y" : 1002
      },
      "to" : {
        "x" : 2048,
        "y" : 1009
      }
    }, {
      "from" : {
        "x" : 2048,
        "y" : 1009
      },
      "to" : {
        "x" : 2081,
        "y" : 1009
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 2042,
        "y" : 1003
      },
      "b" : {
        "x" : 2054,
        "y" : 1015
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 2048,
        "y" : 1009
      }
    },
    "inputs" : [ {
      "id" : 79491
    } ],
    "outputs" : [ {
      "id" : 79480,
      "points" : [ {
        "x" : 896,
        "y" : 727
      }, {
        "x" : 1210,
        "y" : 1105
      }, {
        "x" : 2093,
        "y" : 1095
      } ]
    }, {
      "id" : 79493,
      "points" : [ {
        "x" : 2094,
        "y" : 1007
      } ]
    } ],
    "catalysts" : [ {
      "id" : 79491,
      "points" : [ {
        "x" : 1915,
        "y" : 987
      }, {
        "x" : 2029,
        "y" : 972
      } ]
    } ]
  }, {
    "id" : 79558,
    "reactomeId" : 10092045,
    "displayName" : "UBXN7:UBF1:NPLOC4:VCP hexamer binds NFE2L2:CRL3 complex",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 3317,
      "y" : 1335
    },
    "minX" : 3252,
    "maxX" : 3361,
    "minY" : 1329,
    "maxY" : 1341,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 3252,
        "y" : 1329
      },
      "to" : {
        "x" : 3317,
        "y" : 1335
      }
    }, {
      "from" : {
        "x" : 3317,
        "y" : 1335
      },
      "to" : {
        "x" : 3361,
        "y" : 1333
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 3354,
        "y" : 1337
      },
      "b" : {
        "x" : 3361,
        "y" : 1333
      },
      "c" : {
        "x" : 3354,
        "y" : 1329
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 3354,
        "y" : 1329
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 3317,
        "y" : 1335
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 3317,
        "y" : 1335
      }
    },
    "inputs" : [ {
      "id" : 79557,
      "points" : [ {
        "x" : 3203,
        "y" : 1328
      } ]
    }, {
      "id" : 79552,
      "points" : [ {
        "x" : 3277,
        "y" : 1394
      } ]
    } ],
    "outputs" : [ {
      "id" : 79559
    } ]
  }, {
    "id" : 79494,
    "reactomeId" : 10083790,
    "displayName" : "NEDD8:AcM-UBE2M binds CRL4 E3 ubiquitin ligase complex",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 1274,
      "y" : 1472
    },
    "minX" : 1242,
    "maxX" : 1349,
    "minY" : 1466,
    "maxY" : 1478,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 1242,
        "y" : 1469
      },
      "to" : {
        "x" : 1274,
        "y" : 1472
      }
    }, {
      "from" : {
        "x" : 1274,
        "y" : 1472
      },
      "to" : {
        "x" : 1349,
        "y" : 1470
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 1342,
        "y" : 1474
      },
      "b" : {
        "x" : 1349,
        "y" : 1470
      },
      "c" : {
        "x" : 1342,
        "y" : 1466
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 1342,
        "y" : 1466
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 1274,
        "y" : 1472
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 1274,
        "y" : 1472
      }
    },
    "inputs" : [ {
      "id" : 79495,
      "points" : [ {
        "x" : 1219,
        "y" : 1543
      } ]
    }, {
      "id" : 79496,
      "points" : [ {
        "x" : 1339,
        "y" : 1539
      } ]
    }, {
      "id" : 79497,
      "points" : [ {
        "x" : 1217,
        "y" : 1465
      } ]
    } ],
    "outputs" : [ {
      "id" : 79498
    } ]
  }, {
    "id" : 79561,
    "reactomeId" : 10092139,
    "displayName" : "Ubiquitinated NFE2L2 is extracted from CRL3 complex for degradation",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 3523,
      "y" : 1347
    },
    "minX" : 3494,
    "maxX" : 3582,
    "minY" : 1341,
    "maxY" : 1354,
    "reactionType" : "dissociation",
    "segments" : [ {
      "from" : {
        "x" : 3494,
        "y" : 1341
      },
      "to" : {
        "x" : 3523,
        "y" : 1347
      }
    }, {
      "from" : {
        "x" : 3523,
        "y" : 1347
      },
      "to" : {
        "x" : 3582,
        "y" : 1354
      }
    } ],
    "reactionShape" : {
      "c" : {
        "x" : 3523,
        "y" : 1347
      },
      "r" : 5,
      "r1" : 3,
      "type" : "DOUBLE_CIRCLE",
      "empty" : true,
      "centre" : {
        "x" : 3523,
        "y" : 1347
      }
    },
    "inputs" : [ {
      "id" : 79559
    } ],
    "outputs" : [ {
      "id" : 79557,
      "points" : [ {
        "x" : 3188,
        "y" : 1307
      }, {
        "x" : 3273,
        "y" : 1277
      }, {
        "x" : 3474,
        "y" : 1280
      } ]
    }, {
      "id" : 79562,
      "points" : [ {
        "x" : 3639,
        "y" : 1344
      } ]
    }, {
      "id" : 79563,
      "points" : [ {
        "x" : 2768,
        "y" : 1561
      }, {
        "x" : 3585,
        "y" : 1553
      } ],
      "stoichiometry" : 2
    } ]
  }, {
    "id" : 79560,
    "reactomeId" : 10084127,
    "displayName" : "VHL:EloB,C:NEDD8-CUL2:RBX1 complex binds UBXN7",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 2990,
      "y" : 959
    },
    "minX" : 2818,
    "maxX" : 3163,
    "minY" : 953,
    "maxY" : 972,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 2818,
        "y" : 959
      },
      "to" : {
        "x" : 2990,
        "y" : 959
      }
    }, {
      "from" : {
        "x" : 2990,
        "y" : 959
      },
      "to" : {
        "x" : 3163,
        "y" : 972
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 3156,
        "y" : 975
      },
      "b" : {
        "x" : 3163,
        "y" : 972
      },
      "c" : {
        "x" : 3156,
        "y" : 967
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 3156,
        "y" : 967
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 2990,
        "y" : 959
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 2990,
        "y" : 959
      }
    },
    "inputs" : [ {
      "id" : 79541,
      "points" : [ {
        "x" : 2767,
        "y" : 974
      } ]
    }, {
      "id" : 79524,
      "points" : [ {
        "x" : 2746,
        "y" : 930
      } ]
    } ],
    "outputs" : [ {
      "id" : 79531
    } ],
    "inhibitors" : [ {
      "id" : 79544,
      "points" : [ {
        "x" : 2877,
        "y" : 1116
      } ]
    } ]
  }, {
    "id" : 79499,
    "reactomeId" : 10083788,
    "displayName" : "AcM-UBE2M transfers NEDD8 to CRL4 E3 ubiquitin ligase complex",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 1554,
      "y" : 1473
    },
    "minX" : 1488,
    "maxX" : 1586,
    "minY" : 1467,
    "maxY" : 1479,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 1488,
        "y" : 1470
      },
      "to" : {
        "x" : 1554,
        "y" : 1473
      }
    }, {
      "from" : {
        "x" : 1554,
        "y" : 1473
      },
      "to" : {
        "x" : 1586,
        "y" : 1472
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 1548,
        "y" : 1467
      },
      "b" : {
        "x" : 1560,
        "y" : 1479
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 1554,
        "y" : 1473
      }
    },
    "inputs" : [ {
      "id" : 79498
    } ],
    "outputs" : [ {
      "id" : 79500,
      "points" : [ {
        "x" : 1655,
        "y" : 1471
      } ]
    }, {
      "id" : 79501,
      "points" : [ {
        "x" : 1627,
        "y" : 1512
      } ]
    } ],
    "catalysts" : [ {
      "id" : 79498,
      "points" : [ {
        "x" : 1488,
        "y" : 1447
      }, {
        "x" : 1521,
        "y" : 1436
      } ]
    } ]
  }, {
    "id" : 79564,
    "reactomeId" : 10080490,
    "displayName" : "26S proteasome degrades Ub-NFE2L2",
    "schemaClass" : "BlackBoxEvent",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 3267,
      "y" : 1232
    },
    "minX" : 3012,
    "maxX" : 3664,
    "minY" : 1226,
    "maxY" : 1325,
    "reactionType" : "omitted",
    "segments" : [ {
      "from" : {
        "x" : 3664,
        "y" : 1325
      },
      "to" : {
        "x" : 3561,
        "y" : 1245
      }
    }, {
      "from" : {
        "x" : 3561,
        "y" : 1245
      },
      "to" : {
        "x" : 3267,
        "y" : 1232
      }
    }, {
      "from" : {
        "x" : 3267,
        "y" : 1232
      },
      "to" : {
        "x" : 3012,
        "y" : 1292
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 3018,
        "y" : 1287
      },
      "b" : {
        "x" : 3012,
        "y" : 1292
      },
      "c" : {
        "x" : 3020,
        "y" : 1294
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 3020,
        "y" : 1294
      }
    },
    "reactionShape" : {
      "a" : {
        "x" : 3261,
        "y" : 1226
      },
      "b" : {
        "x" : 3273,
        "y" : 1238
      },
      "s" : "\\\\",
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 3267,
        "y" : 1232
      }
    },
    "inputs" : [ {
      "id" : 79562
    } ],
    "outputs" : [ {
      "id" : 79551
    } ],
    "catalysts" : [ {
      "id" : 79546,
      "points" : [ {
        "x" : 3255,
        "y" : 1120
      } ]
    } ]
  }, {
    "id" : 79502,
    "reactomeId" : 10084045,
    "displayName" : "CAND1 binds cytosolic CRL E3 ubiquitin ligases",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 652,
      "y" : 1171
    },
    "minX" : 607,
    "maxX" : 695,
    "minY" : 1165,
    "maxY" : 1177,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 607,
        "y" : 1170
      },
      "to" : {
        "x" : 652,
        "y" : 1171
      }
    }, {
      "from" : {
        "x" : 652,
        "y" : 1171
      },
      "to" : {
        "x" : 695,
        "y" : 1174
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 688,
        "y" : 1178
      },
      "b" : {
        "x" : 695,
        "y" : 1174
      },
      "c" : {
        "x" : 688,
        "y" : 1170
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 688,
        "y" : 1170
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 652,
        "y" : 1171
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 652,
        "y" : 1171
      }
    },
    "inputs" : [ {
      "id" : 79503,
      "points" : [ {
        "x" : 499,
        "y" : 1194
      } ]
    }, {
      "id" : 79504,
      "points" : [ {
        "x" : 548,
        "y" : 1145
      } ]
    } ],
    "outputs" : [ {
      "id" : 79505
    } ]
  }, {
    "id" : 79506,
    "reactomeId" : 10084057,
    "displayName" : "COMMDs displace CAND1 from cytosolic CRL E3 ubiquitin ligase complexes",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 976,
      "y" : 1174
    },
    "minX" : 889,
    "maxX" : 1028,
    "minY" : 1168,
    "maxY" : 1180,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 889,
        "y" : 1175
      },
      "to" : {
        "x" : 976,
        "y" : 1174
      }
    }, {
      "from" : {
        "x" : 976,
        "y" : 1174
      },
      "to" : {
        "x" : 1028,
        "y" : 1172
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 970,
        "y" : 1168
      },
      "b" : {
        "x" : 982,
        "y" : 1180
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 976,
        "y" : 1174
      }
    },
    "inputs" : [ {
      "id" : 79505,
      "points" : [ {
        "x" : 802,
        "y" : 1177
      } ]
    }, {
      "id" : 79507,
      "points" : [ {
        "x" : 742,
        "y" : 1239
      } ]
    } ],
    "outputs" : [ {
      "id" : 79504,
      "points" : [ {
        "x" : 554,
        "y" : 1130
      }, {
        "x" : 967,
        "y" : 1121
      } ]
    }, {
      "id" : 79508,
      "points" : [ {
        "x" : 1072,
        "y" : 1176
      } ]
    } ]
  }, {
    "id" : 79509,
    "reactomeId" : 10084051,
    "displayName" : "CAND1 binds CRL4 E3 ubiquitin ligase in the nucleus",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 763,
      "y" : 1470
    },
    "minX" : 743,
    "maxX" : 794,
    "minY" : 1464,
    "maxY" : 1476,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 743,
        "y" : 1470
      },
      "to" : {
        "x" : 763,
        "y" : 1470
      }
    }, {
      "from" : {
        "x" : 763,
        "y" : 1470
      },
      "to" : {
        "x" : 794,
        "y" : 1470
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 787,
        "y" : 1474
      },
      "b" : {
        "x" : 794,
        "y" : 1470
      },
      "c" : {
        "x" : 787,
        "y" : 1466
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 787,
        "y" : 1466
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 763,
        "y" : 1470
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 763,
        "y" : 1470
      }
    },
    "inputs" : [ {
      "id" : 79510,
      "points" : [ {
        "x" : 704,
        "y" : 1466
      } ]
    }, {
      "id" : 79511,
      "points" : [ {
        "x" : 697,
        "y" : 1524
      } ]
    } ],
    "outputs" : [ {
      "id" : 79512
    } ]
  }, {
    "id" : 79513,
    "reactomeId" : 10084053,
    "displayName" : "COMMDs displace CAND1 from CRL4 E3 ubiquitin ligase complex",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 990,
      "y" : 1466
    },
    "minX" : 963,
    "maxX" : 1037,
    "minY" : 1460,
    "maxY" : 1472,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 963,
        "y" : 1467
      },
      "to" : {
        "x" : 990,
        "y" : 1466
      }
    }, {
      "from" : {
        "x" : 990,
        "y" : 1466
      },
      "to" : {
        "x" : 1037,
        "y" : 1463
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 984,
        "y" : 1460
      },
      "b" : {
        "x" : 996,
        "y" : 1472
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 990,
        "y" : 1466
      }
    },
    "inputs" : [ {
      "id" : 79514,
      "points" : [ {
        "x" : 947,
        "y" : 1498
      } ]
    }, {
      "id" : 79512,
      "points" : [ {
        "x" : 937,
        "y" : 1468
      } ]
    } ],
    "outputs" : [ {
      "id" : 79511,
      "points" : [ {
        "x" : 720,
        "y" : 1539
      }, {
        "x" : 1069,
        "y" : 1555
      } ]
    }, {
      "id" : 79497,
      "points" : [ {
        "x" : 1086,
        "y" : 1461
      } ]
    } ]
  }, {
    "id" : 79515,
    "reactomeId" : 10084108,
    "displayName" : "COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 2907,
      "y" : 668
    },
    "minX" : 2829,
    "maxX" : 2951,
    "minY" : 662,
    "maxY" : 674,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 2829,
        "y" : 671
      },
      "to" : {
        "x" : 2907,
        "y" : 668
      }
    }, {
      "from" : {
        "x" : 2907,
        "y" : 668
      },
      "to" : {
        "x" : 2951,
        "y" : 667
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 2901,
        "y" : 662
      },
      "b" : {
        "x" : 2913,
        "y" : 674
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 2907,
        "y" : 668
      }
    },
    "inputs" : [ {
      "id" : 79516
    } ],
    "outputs" : [ {
      "id" : 79466,
      "points" : [ {
        "x" : 536,
        "y" : 396
      }, {
        "x" : 1008,
        "y" : 174
      }, {
        "x" : 2787,
        "y" : 164
      } ]
    }, {
      "id" : 79517,
      "points" : [ {
        "x" : 3007,
        "y" : 667
      } ]
    } ],
    "catalysts" : [ {
      "id" : 79518,
      "points" : [ {
        "x" : 2876,
        "y" : 629
      } ]
    } ]
  }, {
    "id" : 79519,
    "reactomeId" : 10084115,
    "displayName" : "COP9 signalosome deneddylates nuclear CRL4 E3 ubiquitin ligase complex",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 1881,
      "y" : 1473
    },
    "minX" : 1810,
    "maxX" : 1959,
    "minY" : 1467,
    "maxY" : 1479,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 1810,
        "y" : 1471
      },
      "to" : {
        "x" : 1881,
        "y" : 1473
      }
    }, {
      "from" : {
        "x" : 1881,
        "y" : 1473
      },
      "to" : {
        "x" : 1959,
        "y" : 1476
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 1875,
        "y" : 1467
      },
      "b" : {
        "x" : 1887,
        "y" : 1479
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 1881,
        "y" : 1473
      }
    },
    "inputs" : [ {
      "id" : 79500
    } ],
    "outputs" : [ {
      "id" : 79520,
      "points" : [ {
        "x" : 2004,
        "y" : 1476
      } ]
    }, {
      "id" : 79521,
      "points" : [ {
        "x" : 2007,
        "y" : 1548
      } ]
    } ],
    "catalysts" : [ {
      "id" : 79522,
      "points" : [ {
        "x" : 1883,
        "y" : 1515
      } ]
    } ]
  }, {
    "id" : 79459,
    "reactomeId" : 10062722,
    "displayName" : "UCHL3, SENP8 cleave NEDD8",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 223,
      "y" : 478
    },
    "minX" : 196,
    "maxX" : 247,
    "minY" : 472,
    "maxY" : 484,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 196,
        "y" : 480
      },
      "to" : {
        "x" : 223,
        "y" : 478
      }
    }, {
      "from" : {
        "x" : 223,
        "y" : 478
      },
      "to" : {
        "x" : 247,
        "y" : 478
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 217,
        "y" : 472
      },
      "b" : {
        "x" : 229,
        "y" : 484
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 223,
        "y" : 478
      }
    },
    "inputs" : [ {
      "id" : 79460,
      "points" : [ {
        "x" : 153,
        "y" : 511
      } ]
    }, {
      "id" : 79461,
      "points" : [ {
        "x" : 171,
        "y" : 477
      } ]
    } ],
    "outputs" : [ {
      "id" : 79462,
      "points" : [ {
        "x" : 297,
        "y" : 478
      } ]
    }, {
      "id" : 79463,
      "points" : [ {
        "x" : 273,
        "y" : 506
      } ]
    } ],
    "catalysts" : [ {
      "id" : 79461,
      "points" : [ {
        "x" : 156,
        "y" : 444
      }, {
        "x" : 177,
        "y" : 434
      } ]
    } ]
  }, {
    "id" : 79523,
    "reactomeId" : 10084132,
    "displayName" : "VHL:EloB,C:NEDD8-CUL2:RBX1 complex binds hydroxyprolyl-HIF-alpha",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 2883,
      "y" : 874
    },
    "minX" : 2841,
    "maxX" : 2915,
    "minY" : 868,
    "maxY" : 880,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 2841,
        "y" : 877
      },
      "to" : {
        "x" : 2883,
        "y" : 874
      }
    }, {
      "from" : {
        "x" : 2883,
        "y" : 874
      },
      "to" : {
        "x" : 2915,
        "y" : 871
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 2908,
        "y" : 876
      },
      "b" : {
        "x" : 2915,
        "y" : 871
      },
      "c" : {
        "x" : 2908,
        "y" : 868
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 2908,
        "y" : 868
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 2883,
        "y" : 874
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 2883,
        "y" : 874
      }
    },
    "inputs" : [ {
      "id" : 79524,
      "points" : [ {
        "x" : 2764,
        "y" : 886
      } ]
    }, {
      "id" : 79525,
      "points" : [ {
        "x" : 2813,
        "y" : 848
      } ]
    } ],
    "outputs" : [ {
      "id" : 79526
    } ]
  }, {
    "id" : 79527,
    "reactomeId" : 10084137,
    "displayName" : "VHL:EloB,C:NEDD8-CUL2:RBX1 complex ubiquitinylates HIF-alpha",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 3259,
      "y" : 857
    },
    "minX" : 3216,
    "maxX" : 3294,
    "minY" : 851,
    "maxY" : 863,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 3216,
        "y" : 855
      },
      "to" : {
        "x" : 3259,
        "y" : 857
      }
    }, {
      "from" : {
        "x" : 3259,
        "y" : 857
      },
      "to" : {
        "x" : 3294,
        "y" : 855
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 3253,
        "y" : 851
      },
      "b" : {
        "x" : 3265,
        "y" : 863
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 3259,
        "y" : 857
      }
    },
    "inputs" : [ {
      "id" : 79528,
      "points" : [ {
        "x" : 3152,
        "y" : 902
      } ]
    }, {
      "id" : 79526,
      "points" : [ {
        "x" : 3136,
        "y" : 858
      } ]
    } ],
    "outputs" : [ {
      "id" : 79529,
      "points" : [ {
        "x" : 3323,
        "y" : 798
      } ]
    }, {
      "id" : 79530,
      "points" : [ {
        "x" : 3340,
        "y" : 857
      } ]
    } ],
    "catalysts" : [ {
      "id" : 79526,
      "points" : [ {
        "x" : 3093,
        "y" : 831
      }, {
        "x" : 3233,
        "y" : 776
      } ]
    } ],
    "inhibitors" : [ {
      "id" : 79531,
      "points" : [ {
        "x" : 3251,
        "y" : 948
      } ]
    } ]
  }, {
    "id" : 79464,
    "reactomeId" : 10082717,
    "displayName" : "Release of mature NEDD8",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 437,
      "y" : 472
    },
    "minX" : 416,
    "maxX" : 461,
    "minY" : 466,
    "maxY" : 485,
    "reactionType" : "dissociation",
    "segments" : [ {
      "from" : {
        "x" : 416,
        "y" : 473
      },
      "to" : {
        "x" : 437,
        "y" : 472
      }
    }, {
      "from" : {
        "x" : 437,
        "y" : 472
      },
      "to" : {
        "x" : 461,
        "y" : 485
      }
    } ],
    "reactionShape" : {
      "c" : {
        "x" : 437,
        "y" : 472
      },
      "r" : 5,
      "r1" : 3,
      "type" : "DOUBLE_CIRCLE",
      "empty" : true,
      "centre" : {
        "x" : 437,
        "y" : 472
      }
    },
    "inputs" : [ {
      "id" : 79462
    } ],
    "outputs" : [ {
      "id" : 79465,
      "points" : [ {
        "x" : 478,
        "y" : 498
      } ]
    }, {
      "id" : 79466,
      "points" : [ {
        "x" : 505,
        "y" : 424
      } ]
    } ]
  }, {
    "id" : 79467,
    "reactomeId" : 10082888,
    "displayName" : "NEDD8:AcM-UBE2F binds CRL5 E3 ubiquitin ligase complex",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 1569,
      "y" : 405
    },
    "minX" : 1526,
    "maxX" : 1605,
    "minY" : 399,
    "maxY" : 411,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 1526,
        "y" : 407
      },
      "to" : {
        "x" : 1569,
        "y" : 405
      }
    }, {
      "from" : {
        "x" : 1569,
        "y" : 405
      },
      "to" : {
        "x" : 1605,
        "y" : 406
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 1598,
        "y" : 410
      },
      "b" : {
        "x" : 1605,
        "y" : 406
      },
      "c" : {
        "x" : 1598,
        "y" : 402
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 1598,
        "y" : 402
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 1569,
        "y" : 405
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 1569,
        "y" : 405
      }
    },
    "inputs" : [ {
      "id" : 79468,
      "points" : [ {
        "x" : 1445,
        "y" : 519
      } ]
    }, {
      "id" : 79469,
      "points" : [ {
        "x" : 1484,
        "y" : 405
      } ]
    }, {
      "id" : 79470,
      "points" : [ {
        "x" : 1373,
        "y" : 287
      } ]
    } ],
    "outputs" : [ {
      "id" : 79471
    } ]
  }, {
    "id" : 79532,
    "reactomeId" : 10084152,
    "displayName" : "NEDD8 and UBD bind NUB1 and the 26S proteasome",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 505,
      "y" : 200
    },
    "minX" : 475,
    "maxX" : 544,
    "minY" : 194,
    "maxY" : 206,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 475,
        "y" : 203
      },
      "to" : {
        "x" : 505,
        "y" : 200
      }
    }, {
      "from" : {
        "x" : 505,
        "y" : 200
      },
      "to" : {
        "x" : 544,
        "y" : 200
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 537,
        "y" : 204
      },
      "b" : {
        "x" : 544,
        "y" : 200
      },
      "c" : {
        "x" : 537,
        "y" : 196
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 537,
        "y" : 196
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 505,
        "y" : 200
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 505,
        "y" : 200
      }
    },
    "inputs" : [ {
      "id" : 79533,
      "points" : [ {
        "x" : 393,
        "y" : 225
      } ]
    }, {
      "id" : 79534,
      "points" : [ {
        "x" : 404,
        "y" : 180
      } ]
    }, {
      "id" : 79535,
      "points" : [ {
        "x" : 403,
        "y" : 134
      } ]
    } ],
    "outputs" : [ {
      "id" : 79536
    } ]
  }, {
    "id" : 79537,
    "reactomeId" : 10084154,
    "displayName" : "26S- and NUB1-mediated degradation of NEDD8, UBD and their conjugates",
    "schemaClass" : "BlackBoxEvent",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 706,
      "y" : 195
    },
    "minX" : 683,
    "maxX" : 761,
    "minY" : 189,
    "maxY" : 201,
    "reactionType" : "omitted",
    "segments" : [ {
      "from" : {
        "x" : 683,
        "y" : 196
      },
      "to" : {
        "x" : 706,
        "y" : 195
      }
    }, {
      "from" : {
        "x" : 706,
        "y" : 195
      },
      "to" : {
        "x" : 761,
        "y" : 195
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 700,
        "y" : 189
      },
      "b" : {
        "x" : 712,
        "y" : 201
      },
      "s" : "\\\\",
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 706,
        "y" : 195
      }
    },
    "inputs" : [ {
      "id" : 79536
    } ],
    "outputs" : [ {
      "id" : 79534,
      "points" : [ {
        "x" : 404,
        "y" : 165
      }, {
        "x" : 644,
        "y" : 126
      } ]
    }, {
      "id" : 79535,
      "points" : [ {
        "x" : 448,
        "y" : 111
      }, {
        "x" : 667,
        "y" : 76
      } ]
    } ]
  }, {
    "id" : 79472,
    "reactomeId" : 10082898,
    "displayName" : "AcM-UBE2F transfers NEDD8 to CRL5 E3 ubiquitin ligase complex",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 1799,
      "y" : 410
    },
    "minX" : 1759,
    "maxX" : 1834,
    "minY" : 404,
    "maxY" : 416,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 1759,
        "y" : 409
      },
      "to" : {
        "x" : 1799,
        "y" : 410
      }
    }, {
      "from" : {
        "x" : 1799,
        "y" : 410
      },
      "to" : {
        "x" : 1834,
        "y" : 410
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 1793,
        "y" : 404
      },
      "b" : {
        "x" : 1805,
        "y" : 416
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 1799,
        "y" : 410
      }
    },
    "inputs" : [ {
      "id" : 79471
    } ],
    "outputs" : [ {
      "id" : 79473,
      "points" : [ {
        "x" : 1865,
        "y" : 407
      } ]
    }, {
      "id" : 79474,
      "points" : [ {
        "x" : 1059,
        "y" : 318
      }, {
        "x" : 1143,
        "y" : 227
      }, {
        "x" : 1854,
        "y" : 221
      } ]
    } ],
    "catalysts" : [ {
      "id" : 79471,
      "points" : [ {
        "x" : 1717,
        "y" : 372
      }, {
        "x" : 1754,
        "y" : 341
      } ]
    } ]
  }, {
    "id" : 79475,
    "reactomeId" : 10083631,
    "displayName" : "NEDD8:AcM-UBE2M binds CRL1 E3 ubiquitin ligase complex",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 1655,
      "y" : 672
    },
    "minX" : 1615,
    "maxX" : 1691,
    "minY" : 666,
    "maxY" : 678,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 1615,
        "y" : 669
      },
      "to" : {
        "x" : 1655,
        "y" : 672
      }
    }, {
      "from" : {
        "x" : 1655,
        "y" : 672
      },
      "to" : {
        "x" : 1691,
        "y" : 669
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 1684,
        "y" : 674
      },
      "b" : {
        "x" : 1691,
        "y" : 669
      },
      "c" : {
        "x" : 1684,
        "y" : 666
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 1684,
        "y" : 666
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 1655,
        "y" : 672
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 1655,
        "y" : 672
      }
    },
    "inputs" : [ {
      "id" : 79476,
      "points" : [ {
        "x" : 1503,
        "y" : 666
      } ]
    }, {
      "id" : 79468,
      "points" : [ {
        "x" : 1453,
        "y" : 554
      } ]
    }, {
      "id" : 79477,
      "points" : [ {
        "x" : 1602,
        "y" : 589
      } ]
    } ],
    "outputs" : [ {
      "id" : 79478
    } ]
  }, {
    "id" : 79538,
    "reactomeId" : 10084156,
    "displayName" : "MyrG-DCUN1D3 binds CRL1 E3 ubiquitin ligase complex",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 2244,
      "y" : 40
    },
    "minX" : 2177,
    "maxX" : 2304,
    "minY" : 34,
    "maxY" : 46,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 2177,
        "y" : 37
      },
      "to" : {
        "x" : 2244,
        "y" : 40
      }
    }, {
      "from" : {
        "x" : 2244,
        "y" : 40
      },
      "to" : {
        "x" : 2304,
        "y" : 38
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 2297,
        "y" : 42
      },
      "b" : {
        "x" : 2304,
        "y" : 38
      },
      "c" : {
        "x" : 2297,
        "y" : 34
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 2297,
        "y" : 34
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 2244,
        "y" : 40
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 2244,
        "y" : 40
      }
    },
    "inputs" : [ {
      "id" : 79477,
      "points" : [ {
        "x" : 1679,
        "y" : 545
      }, {
        "x" : 2074,
        "y" : 479
      } ]
    }, {
      "id" : 79539,
      "points" : [ {
        "x" : 2111,
        "y" : 34
      } ]
    } ],
    "outputs" : [ {
      "id" : 79482
    } ]
  }, {
    "id" : 79540,
    "reactomeId" : 10092025,
    "displayName" : "MUL1 ubiquitinates UBXN7",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 2870,
      "y" : 1080
    },
    "minX" : 2836,
    "maxX" : 2974,
    "minY" : 1074,
    "maxY" : 1086,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 2836,
        "y" : 1079
      },
      "to" : {
        "x" : 2870,
        "y" : 1080
      }
    }, {
      "from" : {
        "x" : 2870,
        "y" : 1080
      },
      "to" : {
        "x" : 2974,
        "y" : 1076
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 2967,
        "y" : 1080
      },
      "b" : {
        "x" : 2974,
        "y" : 1076
      },
      "c" : {
        "x" : 2967,
        "y" : 1072
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 2967,
        "y" : 1072
      }
    },
    "reactionShape" : {
      "a" : {
        "x" : 2864,
        "y" : 1074
      },
      "b" : {
        "x" : 2876,
        "y" : 1086
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 2870,
        "y" : 1080
      }
    },
    "inputs" : [ {
      "id" : 79541,
      "points" : [ {
        "x" : 2745,
        "y" : 998
      } ]
    }, {
      "id" : 79542,
      "points" : [ {
        "x" : 2829,
        "y" : 1032
      } ],
      "stoichiometry" : 3
    } ],
    "outputs" : [ {
      "id" : 79543
    } ],
    "catalysts" : [ {
      "id" : 79544,
      "points" : [ {
        "x" : 2867,
        "y" : 1116
      } ]
    } ]
  }, {
    "id" : 79479,
    "reactomeId" : 10083628,
    "displayName" : "AcM-UBE2M transfers NEDD8 to CRL1 E3 ubiquitin ligase complex",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 1895,
      "y" : 683
    },
    "minX" : 1832,
    "maxX" : 1937,
    "minY" : 674,
    "maxY" : 689,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 1832,
        "y" : 674
      },
      "to" : {
        "x" : 1895,
        "y" : 683
      }
    }, {
      "from" : {
        "x" : 1895,
        "y" : 683
      },
      "to" : {
        "x" : 1937,
        "y" : 688
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 1889,
        "y" : 677
      },
      "b" : {
        "x" : 1901,
        "y" : 689
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 1895,
        "y" : 683
      }
    },
    "inputs" : [ {
      "id" : 79478
    } ],
    "outputs" : [ {
      "id" : 79480,
      "points" : [ {
        "x" : 929,
        "y" : 713
      }, {
        "x" : 1427,
        "y" : 758
      }, {
        "x" : 1881,
        "y" : 744
      } ]
    }, {
      "id" : 79481,
      "points" : [ {
        "x" : 1976,
        "y" : 678
      } ]
    } ],
    "catalysts" : [ {
      "id" : 79478,
      "points" : [ {
        "x" : 1817,
        "y" : 630
      }, {
        "x" : 1836,
        "y" : 622
      } ]
    } ],
    "inhibitors" : [ {
      "id" : 79482,
      "points" : [ {
        "x" : 2374,
        "y" : 70
      }, {
        "x" : 2140,
        "y" : 488
      } ]
    } ]
  }, {
    "id" : 79545,
    "reactomeId" : 10092027,
    "displayName" : "ub UBXN7 is degraded by the 26S proteasome",
    "schemaClass" : "BlackBoxEvent",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 3104,
      "y" : 1025
    },
    "minX" : 2847,
    "maxX" : 3110,
    "minY" : 1008,
    "maxY" : 1053,
    "reactionType" : "omitted",
    "segments" : [ {
      "from" : {
        "x" : 3053,
        "y" : 1053
      },
      "to" : {
        "x" : 3104,
        "y" : 1025
      }
    }, {
      "from" : {
        "x" : 3104,
        "y" : 1025
      },
      "to" : {
        "x" : 3000,
        "y" : 1008
      }
    }, {
      "from" : {
        "x" : 3000,
        "y" : 1008
      },
      "to" : {
        "x" : 2847,
        "y" : 1014
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 2854,
        "y" : 1010
      },
      "b" : {
        "x" : 2847,
        "y" : 1014
      },
      "c" : {
        "x" : 2854,
        "y" : 1018
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 2854,
        "y" : 1018
      }
    },
    "reactionShape" : {
      "a" : {
        "x" : 3098,
        "y" : 1019
      },
      "b" : {
        "x" : 3110,
        "y" : 1031
      },
      "s" : "\\\\",
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 3104,
        "y" : 1025
      }
    },
    "inputs" : [ {
      "id" : 79543
    } ],
    "outputs" : [ {
      "id" : 79542
    } ],
    "catalysts" : [ {
      "id" : 79546,
      "points" : [ {
        "x" : 3233,
        "y" : 1092
      } ]
    } ]
  }, {
    "id" : 79483,
    "reactomeId" : 10083655,
    "displayName" : "NEDD8:AcM-UBE2M binds CRL2 E3 ubiquitin ligase complex",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 1782,
      "y" : 840
    },
    "minX" : 1739,
    "maxX" : 1801,
    "minY" : 834,
    "maxY" : 846,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 1739,
        "y" : 835
      },
      "to" : {
        "x" : 1782,
        "y" : 840
      }
    }, {
      "from" : {
        "x" : 1782,
        "y" : 840
      },
      "to" : {
        "x" : 1801,
        "y" : 837
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 1795,
        "y" : 842
      },
      "b" : {
        "x" : 1801,
        "y" : 837
      },
      "c" : {
        "x" : 1794,
        "y" : 834
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 1794,
        "y" : 834
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 1782,
        "y" : 840
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 1782,
        "y" : 840
      }
    },
    "inputs" : [ {
      "id" : 79476,
      "points" : [ {
        "x" : 1494,
        "y" : 692
      } ]
    }, {
      "id" : 79484,
      "points" : [ {
        "x" : 1517,
        "y" : 962
      } ]
    }, {
      "id" : 79485,
      "points" : [ {
        "x" : 1531,
        "y" : 842
      } ]
    } ],
    "outputs" : [ {
      "id" : 79486
    } ]
  }, {
    "id" : 79547,
    "reactomeId" : 10092018,
    "displayName" : "26S proteasome degrades HIFalpha",
    "schemaClass" : "BlackBoxEvent",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 3590,
      "y" : 876
    },
    "minX" : 3542,
    "maxX" : 3627,
    "minY" : 870,
    "maxY" : 882,
    "reactionType" : "omitted",
    "segments" : [ {
      "from" : {
        "x" : 3542,
        "y" : 871
      },
      "to" : {
        "x" : 3590,
        "y" : 876
      }
    }, {
      "from" : {
        "x" : 3590,
        "y" : 876
      },
      "to" : {
        "x" : 3627,
        "y" : 873
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 3584,
        "y" : 870
      },
      "b" : {
        "x" : 3596,
        "y" : 882
      },
      "s" : "\\\\",
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 3590,
        "y" : 876
      }
    },
    "inputs" : [ {
      "id" : 79530
    } ],
    "outputs" : [ {
      "id" : 79524,
      "points" : [ {
        "x" : 2694,
        "y" : 862
      }, {
        "x" : 2752,
        "y" : 766
      }, {
        "x" : 3663,
        "y" : 755
      } ]
    }, {
      "id" : 79548,
      "points" : [ {
        "x" : 3663,
        "y" : 906
      } ]
    } ],
    "catalysts" : [ {
      "id" : 79546,
      "points" : [ {
        "x" : 3270,
        "y" : 1092
      } ]
    } ]
  }, {
    "id" : 79549,
    "reactomeId" : 10092032,
    "displayName" : "KEAP1:NEDD8-CUL3:RBX1 complex ubiquitinates NFE2L2",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 3063,
      "y" : 1417
    },
    "minX" : 3019,
    "maxX" : 3220,
    "minY" : 1411,
    "maxY" : 1423,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 3019,
        "y" : 1415
      },
      "to" : {
        "x" : 3063,
        "y" : 1417
      }
    }, {
      "from" : {
        "x" : 3063,
        "y" : 1417
      },
      "to" : {
        "x" : 3220,
        "y" : 1415
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 3213,
        "y" : 1419
      },
      "b" : {
        "x" : 3220,
        "y" : 1415
      },
      "c" : {
        "x" : 3213,
        "y" : 1411
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 3213,
        "y" : 1411
      }
    },
    "reactionShape" : {
      "a" : {
        "x" : 3057,
        "y" : 1411
      },
      "b" : {
        "x" : 3069,
        "y" : 1423
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 3063,
        "y" : 1417
      }
    },
    "inputs" : [ {
      "id" : 79550,
      "points" : [ {
        "x" : 2974,
        "y" : 1411
      } ]
    }, {
      "id" : 79551,
      "points" : [ {
        "x" : 2995,
        "y" : 1312
      } ],
      "stoichiometry" : 3
    } ],
    "outputs" : [ {
      "id" : 79552
    } ],
    "catalysts" : [ {
      "id" : 79550,
      "points" : [ {
        "x" : 2954,
        "y" : 1433
      }, {
        "x" : 3015,
        "y" : 1459
      } ]
    } ],
    "inhibitors" : [ {
      "id" : 79553,
      "points" : [ {
        "x" : 3057,
        "y" : 1380
      } ]
    }, {
      "id" : 79554,
      "points" : [ {
        "x" : 3122,
        "y" : 1455
      } ]
    } ]
  }, {
    "id" : 79487,
    "reactomeId" : 10083665,
    "displayName" : "AcM-UBE2M transfers NEDD8 to CRL2 E3 ubiquitin ligase complex",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 2049,
      "y" : 825
    },
    "minX" : 1966,
    "maxX" : 2084,
    "minY" : 819,
    "maxY" : 831,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 1966,
        "y" : 827
      },
      "to" : {
        "x" : 2049,
        "y" : 825
      }
    }, {
      "from" : {
        "x" : 2049,
        "y" : 825
      },
      "to" : {
        "x" : 2084,
        "y" : 825
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 2043,
        "y" : 819
      },
      "b" : {
        "x" : 2055,
        "y" : 831
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 2049,
        "y" : 825
      }
    },
    "inputs" : [ {
      "id" : 79486
    } ],
    "outputs" : [ {
      "id" : 79480,
      "points" : [ {
        "x" : 929,
        "y" : 722
      }, {
        "x" : 1453,
        "y" : 886
      }, {
        "x" : 2084,
        "y" : 878
      } ]
    }, {
      "id" : 79488,
      "points" : [ {
        "x" : 2127,
        "y" : 824
      } ]
    } ],
    "catalysts" : [ {
      "id" : 79486,
      "points" : [ {
        "x" : 1966,
        "y" : 798
      }, {
        "x" : 2006,
        "y" : 781
      } ]
    } ]
  } ],
  "compartments" : [ {
    "id" : 79574,
    "reactomeId" : 7660,
    "displayName" : "nucleoplasm",
    "schemaClass" : "Compartment",
    "renderableClass" : "Compartment",
    "position" : {
      "x" : 1443,
      "y" : 1599
    },
    "minX" : 375,
    "maxX" : 2512,
    "minY" : 1404,
    "maxY" : 1794,
    "prop" : {
      "x" : 375,
      "y" : 1404,
      "width" : 2137,
      "height" : 390
    },
    "textPosition" : {
      "x" : 1221,
      "y" : 1623
    },
    "insets" : {
      "x" : 385,
      "y" : 1414,
      "width" : 2117,
      "height" : 370
    },
    "bgColor" : {
      "r" : 250,
      "g" : 240,
      "b" : 240
    },
    "componentIds" : [ 79498, 79496, 79494, 79499, 79501, 79500, 79495, 79510, 79509, 79512, 79511, 79513, 79497, 79514, 79519, 79522, 79521, 79520 ]
  }, {
    "id" : 79579,
    "reactomeId" : 17927,
    "displayName" : "mitochondrial intermembrane space",
    "schemaClass" : "Compartment",
    "renderableClass" : "Compartment",
    "position" : {
      "x" : 2913,
      "y" : 1195
    },
    "minX" : 2779,
    "maxX" : 3047,
    "minY" : 1137,
    "maxY" : 1253,
    "prop" : {
      "x" : 2779,
      "y" : 1137,
      "width" : 268,
      "height" : 116
    },
    "textPosition" : {
      "x" : 2794,
      "y" : 1156
    },
    "insets" : {
      "x" : 2789,
      "y" : 1147,
      "width" : 248,
      "height" : 96
    },
    "bgColor" : {
      "r" : 250,
      "g" : 240,
      "b" : 240
    },
    "componentIds" : [ 79544 ]
  }, {
    "id" : 79565,
    "reactomeId" : 70101,
    "displayName" : "cytosol",
    "schemaClass" : "Compartment",
    "renderableClass" : "Compartment",
    "position" : {
      "x" : 2092,
      "y" : 1222
    },
    "minX" : 0,
    "maxX" : 4184,
    "minY" : 22,
    "maxY" : 2422,
    "prop" : {
      "x" : 0,
      "y" : 22,
      "width" : 4184,
      "height" : 2400
    },
    "textPosition" : {
      "x" : 728,
      "y" : 861
    },
    "insets" : {
      "x" : 10,
      "y" : 32,
      "width" : 4164,
      "height" : 2380
    },
    "bgColor" : {
      "r" : 250,
      "g" : 240,
      "b" : 240
    },
    "componentIds" : [ 79459, 79460, 79461, 79462, 79463, 79464, 79465, 79466, 79480, 79474, 79467, 79471, 79472, 79475, 79478, 79483, 79487, 79489, 79491, 79492, 79476, 79473, 79574, 79469, 79502, 79504, 79505, 79506, 79468, 79503, 79484, 79508, 79470, 79586, 79490, 79587, 79485, 79588, 79477, 79589, 79507, 79515, 79518, 79516, 79590, 79591, 79592, 79593, 79523, 79529, 79530, 79531, 79541, 79532, 79533, 79594, 79534, 79535, 79536, 79525, 79537, 79538, 79539, 79482, 79540, 79543, 79545, 79546, 79479, 79481, 79488, 79486, 79524, 79579, 79493, 79526, 79527, 79528, 79517, 79547, 79548, 79580, 79563, 79550, 79549, 79552, 79553, 79555, 79556, 79557, 79558, 79559, 79551, 79554, 79542, 79560, 79582, 79595, 79596, 79561, 79562, 79564 ]
  } ],
  "notes" : [ ],
  "links" : [ {
    "id" : 79587,
    "renderableClass" : "EntitySetAndMemberLink",
    "position" : {
      "x" : 1260,
      "y" : 1118
    },
    "minX" : 1186,
    "maxX" : 1335,
    "minY" : 1081,
    "maxY" : 1155,
    "segments" : [ {
      "from" : {
        "x" : 1335,
        "y" : 1081
      },
      "to" : {
        "x" : 1186,
        "y" : 1155
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 1254,
        "y" : 1112
      },
      "b" : {
        "x" : 1266,
        "y" : 1124
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 1260,
        "y" : 1118
      }
    },
    "inputs" : [ {
      "id" : 79490
    } ],
    "outputs" : [ {
      "id" : 79508
    } ]
  }, {
    "id" : 79586,
    "renderableClass" : "EntitySetAndMemberLink",
    "position" : {
      "x" : 1242,
      "y" : 721
    },
    "minX" : 1148,
    "maxX" : 1336,
    "minY" : 287,
    "maxY" : 1155,
    "segments" : [ {
      "from" : {
        "x" : 1336,
        "y" : 287
      },
      "to" : {
        "x" : 1148,
        "y" : 1155
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 1236,
        "y" : 715
      },
      "b" : {
        "x" : 1248,
        "y" : 727
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 1242,
        "y" : 721
      }
    },
    "inputs" : [ {
      "id" : 79470
    } ],
    "outputs" : [ {
      "id" : 79508
    } ]
  }, {
    "id" : 79589,
    "renderableClass" : "EntitySetAndMemberLink",
    "position" : {
      "x" : 1369,
      "y" : 872
    },
    "minX" : 1160,
    "maxX" : 1578,
    "minY" : 589,
    "maxY" : 1155,
    "segments" : [ {
      "from" : {
        "x" : 1578,
        "y" : 589
      },
      "to" : {
        "x" : 1160,
        "y" : 1155
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 1363,
        "y" : 866
      },
      "b" : {
        "x" : 1375,
        "y" : 878
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 1369,
        "y" : 872
      }
    },
    "inputs" : [ {
      "id" : 79477
    } ],
    "outputs" : [ {
      "id" : 79508
    } ]
  }, {
    "id" : 79588,
    "renderableClass" : "EntitySetAndMemberLink",
    "position" : {
      "x" : 1304,
      "y" : 1014
    },
    "minX" : 1165,
    "maxX" : 1444,
    "minY" : 873,
    "maxY" : 1155,
    "segments" : [ {
      "from" : {
        "x" : 1444,
        "y" : 873
      },
      "to" : {
        "x" : 1165,
        "y" : 1155
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 1298,
        "y" : 1008
      },
      "b" : {
        "x" : 1310,
        "y" : 1020
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 1304,
        "y" : 1014
      }
    },
    "inputs" : [ {
      "id" : 79485
    } ],
    "outputs" : [ {
      "id" : 79508
    } ]
  }, {
    "id" : 79591,
    "renderableClass" : "EntitySetAndMemberLink",
    "position" : {
      "x" : 2338,
      "y" : 537
    },
    "minX" : 2016,
    "maxX" : 2661,
    "minY" : 428,
    "maxY" : 647,
    "segments" : [ {
      "from" : {
        "x" : 2016,
        "y" : 428
      },
      "to" : {
        "x" : 2661,
        "y" : 647
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 2332,
        "y" : 531
      },
      "b" : {
        "x" : 2344,
        "y" : 543
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 2338,
        "y" : 537
      }
    },
    "inputs" : [ {
      "id" : 79473
    } ],
    "outputs" : [ {
      "id" : 79516
    } ]
  }, {
    "id" : 79590,
    "renderableClass" : "EntitySetAndMemberLink",
    "position" : {
      "x" : 2460,
      "y" : 750
    },
    "minX" : 2260,
    "maxX" : 2661,
    "minY" : 695,
    "maxY" : 806,
    "segments" : [ {
      "from" : {
        "x" : 2260,
        "y" : 806
      },
      "to" : {
        "x" : 2661,
        "y" : 695
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 2454,
        "y" : 744
      },
      "b" : {
        "x" : 2466,
        "y" : 756
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 2460,
        "y" : 750
      }
    },
    "inputs" : [ {
      "id" : 79488
    } ],
    "outputs" : [ {
      "id" : 79516
    } ]
  }, {
    "id" : 79593,
    "renderableClass" : "EntitySetAndMemberLink",
    "position" : {
      "x" : 2380,
      "y" : 669
    },
    "minX" : 2099,
    "maxX" : 2661,
    "minY" : 663,
    "maxY" : 675,
    "segments" : [ {
      "from" : {
        "x" : 2099,
        "y" : 666
      },
      "to" : {
        "x" : 2661,
        "y" : 673
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 2374,
        "y" : 663
      },
      "b" : {
        "x" : 2386,
        "y" : 675
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 2380,
        "y" : 669
      }
    },
    "inputs" : [ {
      "id" : 79481
    } ],
    "outputs" : [ {
      "id" : 79516
    } ]
  }, {
    "id" : 79592,
    "renderableClass" : "EntitySetAndMemberLink",
    "position" : {
      "x" : 2448,
      "y" : 844
    },
    "minX" : 2220,
    "maxX" : 2677,
    "minY" : 718,
    "maxY" : 970,
    "segments" : [ {
      "from" : {
        "x" : 2220,
        "y" : 970
      },
      "to" : {
        "x" : 2677,
        "y" : 718
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 2442,
        "y" : 838
      },
      "b" : {
        "x" : 2454,
        "y" : 850
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 2448,
        "y" : 844
      }
    },
    "inputs" : [ {
      "id" : 79493
    } ],
    "outputs" : [ {
      "id" : 79516
    } ]
  }, {
    "id" : 79595,
    "renderableClass" : "Interaction",
    "position" : {
      "x" : 2653,
      "y" : 1451
    },
    "minX" : 2642,
    "maxX" : 2664,
    "minY" : 1445,
    "maxY" : 1457,
    "interactionType" : "Activate",
    "segments" : [ {
      "from" : {
        "x" : 2642,
        "y" : 1457
      },
      "to" : {
        "x" : 2664,
        "y" : 1445
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 2660,
        "y" : 1452
      },
      "b" : {
        "x" : 2664,
        "y" : 1445
      },
      "c" : {
        "x" : 2656,
        "y" : 1445
      },
      "type" : "ARROW",
      "empty" : true,
      "centre" : {
        "x" : 2656,
        "y" : 1445
      }
    },
    "reactionShape" : {
      "a" : {
        "x" : 2647,
        "y" : 1445
      },
      "b" : {
        "x" : 2659,
        "y" : 1457
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 2653,
        "y" : 1451
      }
    },
    "inputs" : [ {
      "id" : 79582
    } ],
    "outputs" : [ {
      "id" : 79580
    } ]
  }, {
    "id" : 79594,
    "renderableClass" : "EntitySetAndMemberLink",
    "position" : {
      "x" : 436,
      "y" : 327
    },
    "minX" : 371,
    "maxX" : 502,
    "minY" : 259,
    "maxY" : 396,
    "segments" : [ {
      "from" : {
        "x" : 502,
        "y" : 396
      },
      "to" : {
        "x" : 371,
        "y" : 259
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 430,
        "y" : 321
      },
      "b" : {
        "x" : 442,
        "y" : 333
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 436,
        "y" : 327
      }
    },
    "inputs" : [ {
      "id" : 79466
    } ],
    "outputs" : [ {
      "id" : 79533
    } ]
  }, {
    "id" : 79596,
    "renderableClass" : "Interaction",
    "position" : {
      "x" : 2655,
      "y" : 1531
    },
    "minX" : 2639,
    "maxX" : 2671,
    "minY" : 1521,
    "maxY" : 1541,
    "interactionType" : "Activate",
    "segments" : [ {
      "from" : {
        "x" : 2639,
        "y" : 1521
      },
      "to" : {
        "x" : 2671,
        "y" : 1541
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 2663,
        "y" : 1541
      },
      "b" : {
        "x" : 2671,
        "y" : 1541
      },
      "c" : {
        "x" : 2667,
        "y" : 1534
      },
      "type" : "ARROW",
      "empty" : true,
      "centre" : {
        "x" : 2667,
        "y" : 1534
      }
    },
    "reactionShape" : {
      "a" : {
        "x" : 2649,
        "y" : 1525
      },
      "b" : {
        "x" : 2661,
        "y" : 1537
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 2655,
        "y" : 1531
      }
    },
    "inputs" : [ {
      "id" : 79582
    } ],
    "outputs" : [ {
      "id" : 79563
    } ]
  } ],
  "shadows" : [ ],
  "minX" : 0,
  "maxX" : 4184,
  "minY" : 0,
  "maxY" : 2422,
  "disease" : false
}