{
  "dbId" : 10100743,
  "stId" : "R-MMU-1592230",
  "speciesName" : "Mus musculus",
  "nodes" : [ {
    "dbId" : 10061592,
    "stId" : "R-MMU-5688311",
    "displayName" : "ACSS2 [mitochondrial matrix]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48892,
    "identifier" : "Q9QXG4",
    "standardIdentifier" : "uniprot:Q9QXG4",
    "referenceType" : "ReferenceGeneProduct",
    "parents" : [ 10061594 ],
    "children" : [ ]
  }, {
    "dbId" : 5688340,
    "stId" : "R-ALL-5688340",
    "displayName" : "2'-O-acetyl-ADP-ribose [mitochondrial intermembrane space]",
    "schemaClass" : "SimpleEntity",
    "speciesId" : 0,
    "diagramIds" : [ 26765 ],
    "identifier" : "76279",
    "standardIdentifier" : "chebi:76279",
    "referenceType" : "ReferenceMolecule",
    "parents" : [ ],
    "children" : [ ]
  }, {
    "dbId" : 10101593,
    "stId" : "R-MMU-8949613",
    "displayName" : "Cristae formation",
    "schemaClass" : "Pathway",
    "speciesId" : 48892,
    "diagramIds" : [ 26805 ]
  }, {
    "dbId" : 10061594,
    "stId" : "R-MMU-5688291",
    "displayName" : "ACCS2,GLUD,IDH2,SOD2 [mitochondrial matrix]",
    "schemaClass" : "DefinedSet",
    "speciesId" : 48892,
    "diagramIds" : [ 26758 ],
    "parents" : [ ],
    "children" : [ 9986423, 10048375, 10018990, 10061592 ]
  }, {
    "dbId" : 5688274,
    "stId" : "R-ALL-5688274",
    "displayName" : "NAM [mitochondrial matrix]",
    "schemaClass" : "SimpleEntity",
    "speciesId" : 0,
    "diagramIds" : [ 26752, 26759 ],
    "identifier" : "17154",
    "standardIdentifier" : "chebi:17154",
    "referenceType" : "ReferenceMolecule",
    "parents" : [ ],
    "children" : [ ]
  }, {
    "dbId" : 10061597,
    "stId" : "R-MMU-1605416",
    "displayName" : "SIRT3(?-399) [mitochondrial matrix]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48892,
    "identifier" : "Q8R104",
    "standardIdentifier" : "uniprot:Q8R104",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "Sirt3", "Sir2l3" ],
    "parents" : [ 10061599 ],
    "children" : [ ]
  }, {
    "dbId" : 10061599,
    "stId" : "R-MMU-5688322",
    "displayName" : "SIRT3(?-399):Zn2+ [mitochondrial matrix]",
    "schemaClass" : "Complex",
    "speciesId" : 48892,
    "diagramIds" : [ 26760 ],
    "parents" : [ ],
    "children" : [ 880067, 10061597 ]
  }, {
    "dbId" : 5688337,
    "stId" : "R-ALL-5688337",
    "displayName" : "2'-O-acetyl-ADP-ribose [mitochondrial matrix]",
    "schemaClass" : "SimpleEntity",
    "speciesId" : 0,
    "diagramIds" : [ 26757 ],
    "identifier" : "83767",
    "standardIdentifier" : "chebi:83767",
    "referenceType" : "ReferenceMolecule",
    "parents" : [ ],
    "children" : [ ]
  }, {
    "dbId" : 10061585,
    "stId" : "R-MMU-5688293",
    "displayName" : "Ack-GLUD1 [mitochondrial matrix]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48892,
    "identifier" : "P26443",
    "standardIdentifier" : "uniprot:P26443",
    "referenceType" : "ReferenceGeneProduct",
    "parents" : [ 10061590 ],
    "children" : [ ]
  }, {
    "dbId" : 5688282,
    "stId" : "R-ALL-5688282",
    "displayName" : "NAD+ [mitochondrial intermembrane space]",
    "schemaClass" : "SimpleEntity",
    "speciesId" : 0,
    "diagramIds" : [ 26763 ],
    "identifier" : "57540",
    "standardIdentifier" : "chebi:57540",
    "referenceType" : "ReferenceMolecule",
    "parents" : [ ],
    "children" : [ ]
  }, {
    "dbId" : 10061588,
    "stId" : "R-MMU-5688342",
    "displayName" : "AcK-SOD2 [mitochondrial matrix]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48892,
    "identifier" : "P09671",
    "standardIdentifier" : "uniprot:P09671",
    "referenceType" : "ReferenceGeneProduct",
    "parents" : [ 10061590 ],
    "children" : [ ]
  }, {
    "dbId" : 880067,
    "stId" : "R-ALL-880067",
    "displayName" : "Zn2+ [mitochondrial matrix]",
    "schemaClass" : "SimpleEntity",
    "speciesId" : 0,
    "identifier" : "29105",
    "standardIdentifier" : "chebi:29105",
    "referenceType" : "ReferenceMolecule",
    "parents" : [ 10061576, 10061599 ],
    "children" : [ ]
  }, {
    "dbId" : 5688281,
    "stId" : "R-ALL-5688281",
    "displayName" : "NAM [mitochondrial intermembrane space]",
    "schemaClass" : "SimpleEntity",
    "speciesId" : 0,
    "diagramIds" : [ 26764 ],
    "identifier" : "17154",
    "standardIdentifier" : "chebi:17154",
    "referenceType" : "ReferenceMolecule",
    "parents" : [ ],
    "children" : [ ]
  }, {
    "dbId" : 10061590,
    "stId" : "R-MMU-5688306",
    "displayName" : "Ack-ACCS2,AcK-GLUD,AcK-IDH2,Ack-SOD2 [mitochondrial matrix]",
    "schemaClass" : "DefinedSet",
    "speciesId" : 48892,
    "diagramIds" : [ 26755 ],
    "parents" : [ ],
    "children" : [ 10061588, 10018996, 10061585, 10061582 ]
  }, {
    "dbId" : 10061576,
    "stId" : "R-MMU-5688269",
    "displayName" : "SIRT4:Zn2+ [mitochondrial matrix]",
    "schemaClass" : "Complex",
    "speciesId" : 48892,
    "diagramIds" : [ 26753 ],
    "parents" : [ ],
    "children" : [ 10061574, 880067 ]
  }, {
    "dbId" : 10061582,
    "stId" : "R-MMU-5688284",
    "displayName" : "AcK-ACSS2 [mitochondrial matrix]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48892,
    "identifier" : "Q9QXG4",
    "standardIdentifier" : "uniprot:Q9QXG4",
    "referenceType" : "ReferenceGeneProduct",
    "parents" : [ 10061590 ],
    "children" : [ ]
  }, {
    "dbId" : 10034433,
    "stId" : "R-MMU-1592211",
    "displayName" : "Gabpb1 [nucleoplasm]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48892,
    "diagramIds" : [ 26743 ],
    "identifier" : "Q00420",
    "standardIdentifier" : "uniprot:Q00420",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "Gabpb1" ],
    "parents" : [ 10034435 ],
    "children" : [ ]
  }, {
    "dbId" : 10034435,
    "stId" : "R-MMU-1592226",
    "displayName" : "NRF2 [nucleoplasm]",
    "schemaClass" : "Complex",
    "speciesId" : 48892,
    "diagramIds" : [ 26747 ],
    "parents" : [ ],
    "children" : [ 10034423, 10034433, 10034431, 10034429, 10034427 ]
  }, {
    "dbId" : 10061570,
    "stId" : "R-MMU-5688244",
    "displayName" : "phospho-RibC-GLUD1 [mitochondrial matrix]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48892,
    "diagramIds" : [ 26751 ],
    "identifier" : "P26443",
    "standardIdentifier" : "uniprot:P26443",
    "referenceType" : "ReferenceGeneProduct",
    "parents" : [ ],
    "children" : [ ]
  }, {
    "dbId" : 10061574,
    "stId" : "R-MMU-5687775",
    "displayName" : "SIRT4 [mitochondrial matrix]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48892,
    "identifier" : "Q8R216",
    "standardIdentifier" : "uniprot:Q8R216",
    "referenceType" : "ReferenceGeneProduct",
    "parents" : [ 10061576 ],
    "children" : [ ]
  }, {
    "dbId" : 10101627,
    "stId" : "R-MMU-1268020",
    "displayName" : "Mitochondrial protein import",
    "schemaClass" : "Pathway",
    "speciesId" : 48892,
    "diagramIds" : [ 26800 ]
  }, {
    "dbId" : 10034427,
    "stId" : "R-MMU-1592201",
    "displayName" : "Gabpb1 [nucleoplasm]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48892,
    "diagramIds" : [ 26744 ],
    "identifier" : "Q00420",
    "standardIdentifier" : "uniprot:Q00420",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "Gabpb1" ],
    "parents" : [ 10034435 ],
    "children" : [ ]
  }, {
    "dbId" : 3777117,
    "stId" : "R-ALL-3777117",
    "displayName" : "Zn2+ [mitochondrial intermembrane space]",
    "schemaClass" : "SimpleEntity",
    "speciesId" : 0,
    "identifier" : "29105",
    "standardIdentifier" : "chebi:29105",
    "referenceType" : "ReferenceMolecule",
    "parents" : [ 10061608 ],
    "children" : [ ]
  }, {
    "dbId" : 10034429,
    "stId" : "R-MMU-1592200",
    "displayName" : "Gabpb1 [nucleoplasm]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48892,
    "diagramIds" : [ 26742 ],
    "identifier" : "Q00420",
    "standardIdentifier" : "uniprot:Q00420",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "Gabpb1" ],
    "parents" : [ 10034435 ],
    "children" : [ ]
  }, {
    "dbId" : 10034431,
    "stId" : "R-MMU-1592216",
    "displayName" : "Gabpb1 [nucleoplasm]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48892,
    "diagramIds" : [ 26745 ],
    "identifier" : "Q00420",
    "standardIdentifier" : "uniprot:Q00420",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "Gabpb1" ],
    "parents" : [ 10034435 ],
    "children" : [ ]
  }, {
    "dbId" : 9992882,
    "stId" : "R-MMU-114244",
    "displayName" : "CYCS [mitochondrial intermembrane space]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48892,
    "diagramIds" : [ 26766 ],
    "identifier" : "P62897",
    "standardIdentifier" : "uniprot:P62897",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "Cycs" ],
    "parents" : [ ],
    "children" : [ ]
  }, {
    "dbId" : 10018996,
    "stId" : "R-MMU-5688283",
    "displayName" : "AcK-IDH2 [mitochondrial matrix]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48892,
    "identifier" : "P54071",
    "standardIdentifier" : "uniprot:P54071",
    "referenceType" : "ReferenceGeneProduct",
    "parents" : [ 10061590 ],
    "children" : [ ]
  }, {
    "dbId" : 10048375,
    "stId" : "R-MMU-3299687",
    "displayName" : "SOD2 [mitochondrial matrix]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48892,
    "identifier" : "P09671",
    "standardIdentifier" : "uniprot:P09671",
    "referenceType" : "ReferenceGeneProduct",
    "parents" : [ 10061594 ],
    "children" : [ ]
  }, {
    "dbId" : 10034423,
    "stId" : "R-MMU-1592206",
    "displayName" : "Gabpa [nucleoplasm]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48892,
    "diagramIds" : [ 26746 ],
    "identifier" : "Q00422",
    "standardIdentifier" : "uniprot:Q00422",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "Gabpa" ],
    "parents" : [ 10034435 ],
    "children" : [ ]
  }, {
    "dbId" : 9986423,
    "stId" : "R-MMU-70582",
    "displayName" : "GLUD1 [mitochondrial matrix]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48892,
    "diagramIds" : [ 26750 ],
    "identifier" : "P26443",
    "standardIdentifier" : "uniprot:P26443",
    "referenceType" : "ReferenceGeneProduct",
    "parents" : [ 10061594 ],
    "children" : [ ]
  }, {
    "dbId" : 10061608,
    "stId" : "R-MMU-5688288",
    "displayName" : "SIRT5:Zn2+ [mitochondrial intermembrane space]",
    "schemaClass" : "Complex",
    "speciesId" : 48892,
    "diagramIds" : [ 26767 ],
    "parents" : [ ],
    "children" : [ 9955432, 3777117 ]
  }, {
    "dbId" : 10018990,
    "stId" : "R-MMU-450988",
    "displayName" : "IDH2 [mitochondrial matrix]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48892,
    "identifier" : "P54071",
    "standardIdentifier" : "uniprot:P54071",
    "referenceType" : "ReferenceGeneProduct",
    "parents" : [ 10061594 ],
    "children" : [ ]
  }, {
    "dbId" : 113526,
    "stId" : "R-ALL-113526",
    "displayName" : "NAD+ [mitochondrial matrix]",
    "schemaClass" : "SimpleEntity",
    "speciesId" : 0,
    "diagramIds" : [ 26756, 26749 ],
    "identifier" : "57540",
    "standardIdentifier" : "chebi:57540",
    "referenceType" : "ReferenceMolecule",
    "parents" : [ ],
    "children" : [ ]
  }, {
    "dbId" : 10061605,
    "stId" : "R-MMU-5688308",
    "displayName" : "AcK-CYCS [mitochondrial intermembrane space]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48892,
    "diagramIds" : [ 26762 ],
    "identifier" : "P62897",
    "standardIdentifier" : "uniprot:P62897",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "Cycs" ],
    "parents" : [ ],
    "children" : [ ]
  }, {
    "dbId" : 9955432,
    "stId" : "R-MMU-9955432",
    "displayName" : "Sirt5 [mitochondrial matrix]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48892,
    "identifier" : "Q8K2C6",
    "standardIdentifier" : "uniprot:Q8K2C6",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "Sirt5", "Sir2l5" ],
    "parents" : [ 10061608 ],
    "children" : [ ]
  } ],
  "edges" : [ {
    "dbId" : 10061579,
    "stId" : "R-MMU-5688276",
    "displayName" : "SIRT4 transfers ADPRib to GLUD",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "inputs" : [ 9986423, 113526 ],
    "outputs" : [ 10061570, 5688274 ],
    "catalysts" : [ 10061576 ],
    "efs" : [ ],
    "diagramIds" : [ 26748 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10061611,
    "stId" : "R-MMU-5688294",
    "displayName" : "SIRT5 deacetylates Cytochrome C",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "inputs" : [ 5688282, 10061605 ],
    "outputs" : [ 5688281, 9992882, 5688340 ],
    "catalysts" : [ 10061608 ],
    "efs" : [ ],
    "diagramIds" : [ 26761 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10061602,
    "stId" : "R-MMU-5688289",
    "displayName" : "SIRT3 deacetylates ACCS2, GLUD, IDH2, SOD2",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "inputs" : [ 10061590, 113526 ],
    "outputs" : [ 5688337, 5688274, 10061594 ],
    "catalysts" : [ 10061599 ],
    "efs" : [ ],
    "diagramIds" : [ 26754 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10034437,
    "stId" : "R-MMU-1592240",
    "displayName" : "Formation of NRF2",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "inputs" : [ 10034423, 10034433, 10034431, 10034429, 10034427 ],
    "outputs" : [ 10034435 ],
    "efs" : [ ],
    "diagramIds" : [ 26741 ],
    "entityFunctionalStatus" : [ ]
  } ],
  "subpathways" : [ {
    "dbId" : 10100741,
    "stId" : "R-MMU-2151201",
    "displayName" : "Transcriptional activation of mitochondrial biogenesis",
    "events" : [ 10061579, 10061611, 10061602, 10034437 ]
  } ]
}