{ "dbId" : 10100343, "stableId" : "R-MMU-5627123", "displayName" : "RHO GTPases activate PAKs", "nodes" : [ { "id" : 74305, "reactomeId" : 113592, "displayName" : "ATP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 588, "y" : 377 }, "minX" : 538, "maxX" : 611, "minY" : 363, "maxY" : 390, "prop" : { "x" : 567, "y" : 364, "width" : 43, "height" : 26 }, "textPosition" : { "x" : 573, "y" : 366 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 605, "y" : 369 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 605, "y" : 369 } } }, "connectors" : [ { "edgeId" : 74303, "type" : "INPUT", "segments" : [ { "from" : { "x" : 564, "y" : 381 }, "to" : { "x" : 538, "y" : 388 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 74304, "reactomeId" : 10013859, "displayName" : "LIMK1", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 539, "y" : 342 }, "minX" : 517, "maxX" : 567, "minY" : 325, "maxY" : 388, "prop" : { "x" : 517, "y" : 331, "width" : 44, "height" : 22 }, "textPosition" : { "x" : 518, "y" : 331 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 561, "y" : 331 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 561, "y" : 331 } } }, "connectors" : [ { "edgeId" : 74303, "type" : "INPUT", "segments" : [ { "from" : { "x" : 538, "y" : 356 }, "to" : { "x" : 538, "y" : 388 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 74307, "reactomeId" : 29370, "displayName" : "ADP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 592, "y" : 459 }, "minX" : 540, "maxX" : 615, "minY" : 445, "maxY" : 472, "prop" : { "x" : 570, "y" : 446, "width" : 44, "height" : 26 }, "textPosition" : { "x" : 575, "y" : 448 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 609, "y" : 451 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 609, "y" : 451 } } }, "connectors" : [ { "edgeId" : 74303, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 567, "y" : 455 }, "to" : { "x" : 540, "y" : 451 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 560, "y" : 458 }, "b" : { "x" : 567, "y" : 455 }, "c" : { "x" : 561, "y" : 450 }, "type" : "ARROW", "centre" : { "x" : 561, "y" : 450 } } } ] }, { "id" : 74306, "reactomeId" : 10013862, "displayName" : "phospho-p-T508-LIMK1", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 542, "y" : 506 }, "minX" : 493, "maxX" : 597, "minY" : 451, "maxY" : 517, "prop" : { "x" : 493, "y" : 495, "width" : 98, "height" : 22 }, "textPosition" : { "x" : 502, "y" : 489 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 591, "y" : 495 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 591, "y" : 495 } } }, "connectors" : [ { "edgeId" : 74303, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 541, "y" : 492 }, "to" : { "x" : 540, "y" : 451 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 537, "y" : 485 }, "b" : { "x" : 541, "y" : 492 }, "c" : { "x" : 545, "y" : 485 }, "type" : "ARROW", "centre" : { "x" : 545, "y" : 485 } } } ] }, { "id" : 74308, "reactomeId" : 10013727, "displayName" : "phospho-p-S144,T423-PAK1", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 638, "y" : 302 }, "minX" : 547, "maxX" : 867, "minY" : 281, "maxY" : 781, "prop" : { "x" : 573, "y" : 287, "width" : 130, "height" : 30 }, "textPosition" : { "x" : 580, "y" : 285 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 703, "y" : 287 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 703, "y" : 287 } } }, "connectors" : [ { "edgeId" : 74336, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 642, "y" : 320 }, "to" : { "x" : 762, "y" : 699 } }, { "from" : { "x" : 762, "y" : 699 }, "to" : { "x" : 648, "y" : 781 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 648, "y" : 325 }, "b" : { "x" : 642, "y" : 320 }, "c" : { "x" : 640, "y" : 328 }, "type" : "ARROW", "centre" : { "x" : 640, "y" : 328 } } }, { "edgeId" : 74315, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 706, "y" : 302 }, "to" : { "x" : 730, "y" : 303 } }, { "from" : { "x" : 730, "y" : 303 }, "to" : { "x" : 772, "y" : 620 } }, { "from" : { "x" : 772, "y" : 620 }, "to" : { "x" : 860, "y" : 667 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 863, "y" : 669 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 863, "y" : 669 } } }, { "edgeId" : 74333, "type" : "INPUT", "segments" : [ { "from" : { "x" : 637, "y" : 320 }, "to" : { "x" : 632, "y" : 555 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 74303, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 634, "y" : 320 }, "to" : { "x" : 612, "y" : 409 } }, { "from" : { "x" : 612, "y" : 409 }, "to" : { "x" : 555, "y" : 415 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 551, "y" : 416 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 551, "y" : 416 } } } ] }, { "id" : 74311, "reactomeId" : 113592, "displayName" : "ATP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 899, "y" : 323 }, "minX" : 877, "maxX" : 922, "minY" : 308, "maxY" : 370, "prop" : { "x" : 877, "y" : 309, "width" : 44, "height" : 29 }, "textPosition" : { "x" : 883, "y" : 313 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 916, "y" : 314 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 916, "y" : 314 } } }, "connectors" : [ { "edgeId" : 74309, "type" : "INPUT", "segments" : [ { "from" : { "x" : 903, "y" : 341 }, "to" : { "x" : 912, "y" : 370 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 74310, "reactomeId" : 10059135, "displayName" : "Smooth muscle/non-muscle myosin II", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 817, "y" : 374 }, "minX" : 751, "maxX" : 912, "minY" : 343, "maxY" : 399, "prop" : { "x" : 751, "y" : 349, "width" : 133, "height" : 50 }, "textPosition" : { "x" : 751, "y" : 350 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 884, "y" : 349 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 884, "y" : 349 } } }, "connectors" : [ { "edgeId" : 74309, "type" : "INPUT", "segments" : [ { "from" : { "x" : 887, "y" : 371 }, "to" : { "x" : 912, "y" : 370 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 74313, "reactomeId" : 10059144, "displayName" : "p-T19-MRLC-Smooth muscle/non-muscle myosin II", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 1083, "y" : 372 }, "minX" : 964, "maxX" : 1157, "minY" : 342, "maxY" : 397, "prop" : { "x" : 1015, "y" : 348, "width" : 136, "height" : 49 }, "textPosition" : { "x" : 1015, "y" : 348 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1151, "y" : 348 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1151, "y" : 348 } } }, "connectors" : [ { "edgeId" : 74309, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 1012, "y" : 370 }, "to" : { "x" : 964, "y" : 370 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1005, "y" : 374 }, "b" : { "x" : 1012, "y" : 370 }, "c" : { "x" : 1005, "y" : 366 }, "type" : "ARROW", "centre" : { "x" : 1005, "y" : 366 } } } ] }, { "id" : 74312, "reactomeId" : 29370, "displayName" : "ADP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 990, "y" : 324 }, "minX" : 964, "maxX" : 1012, "minY" : 308, "maxY" : 370, "prop" : { "x" : 970, "y" : 309, "width" : 41, "height" : 30 }, "textPosition" : { "x" : 974, "y" : 313 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1006, "y" : 314 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1006, "y" : 314 } } }, "connectors" : [ { "edgeId" : 74309, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 981, "y" : 342 }, "to" : { "x" : 964, "y" : 370 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 981, "y" : 350 }, "b" : { "x" : 981, "y" : 342 }, "c" : { "x" : 974, "y" : 346 }, "type" : "ARROW", "centre" : { "x" : 974, "y" : 346 } } } ] }, { "id" : 74314, "reactomeId" : 10013731, "displayName" : "phospho-p-S141,T402-PAK2", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 940, "y" : 272 }, "minX" : 873, "maxX" : 1013, "minY" : 252, "maxY" : 362, "prop" : { "x" : 873, "y" : 258, "width" : 134, "height" : 29 }, "textPosition" : { "x" : 882, "y" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1007, "y" : 258 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1007, "y" : 258 } } }, "connectors" : [ { "edgeId" : 74309, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 940, "y" : 290 }, "to" : { "x" : 942, "y" : 354 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 943, "y" : 358 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 943, "y" : 358 } } } ] }, { "id" : 74317, "reactomeId" : 113592, "displayName" : "ATP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 941, "y" : 652 }, "minX" : 874, "maxX" : 961, "minY" : 636, "maxY" : 667, "prop" : { "x" : 922, "y" : 637, "width" : 38, "height" : 30 }, "textPosition" : { "x" : 925, "y" : 641 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 955, "y" : 642 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 955, "y" : 642 } } }, "connectors" : [ { "edgeId" : 74315, "type" : "INPUT", "segments" : [ { "from" : { "x" : 919, "y" : 652 }, "to" : { "x" : 874, "y" : 652 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 74316, "reactomeId" : 10059153, "displayName" : "Myosin phosphatase", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 872, "y" : 609 }, "minX" : 825, "maxX" : 925, "minY" : 586, "maxY" : 652, "prop" : { "x" : 825, "y" : 592, "width" : 94, "height" : 35 }, "textPosition" : { "x" : 826, "y" : 592 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 919, "y" : 592 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 919, "y" : 592 } } }, "connectors" : [ { "edgeId" : 74315, "type" : "INPUT", "segments" : [ { "from" : { "x" : 872, "y" : 630 }, "to" : { "x" : 874, "y" : 652 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 74319, "reactomeId" : 10059158, "displayName" : "p-T696-PPP1R12A-Myosin phosphatase", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 876, "y" : 764 }, "minX" : 813, "maxX" : 945, "minY" : 701, "maxY" : 789, "prop" : { "x" : 813, "y" : 739, "width" : 126, "height" : 50 }, "textPosition" : { "x" : 814, "y" : 740 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 939, "y" : 739 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 939, "y" : 739 } } }, "connectors" : [ { "edgeId" : 74315, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 875, "y" : 736 }, "to" : { "x" : 875, "y" : 701 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 871, "y" : 729 }, "b" : { "x" : 875, "y" : 736 }, "c" : { "x" : 879, "y" : 729 }, "type" : "ARROW", "centre" : { "x" : 879, "y" : 729 } } } ] }, { "id" : 74318, "reactomeId" : 29370, "displayName" : "ADP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 937, "y" : 702 }, "minX" : 875, "maxX" : 960, "minY" : 687, "maxY" : 717, "prop" : { "x" : 915, "y" : 688, "width" : 44, "height" : 29 }, "textPosition" : { "x" : 920, "y" : 692 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 954, "y" : 693 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 954, "y" : 693 } } }, "connectors" : [ { "edgeId" : 74315, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 912, "y" : 701 }, "to" : { "x" : 875, "y" : 701 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 905, "y" : 705 }, "b" : { "x" : 912, "y" : 701 }, "c" : { "x" : 905, "y" : 697 }, "type" : "ARROW", "centre" : { "x" : 905, "y" : 697 } } } ] }, { "id" : 74321, "reactomeId" : 10017684, "displayName" : "MYLK(1-1914)", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 1118, "y" : 304 }, "minX" : 1069, "maxX" : 1209, "minY" : 274, "maxY" : 331, "prop" : { "x" : 1069, "y" : 293, "width" : 98, "height" : 22 }, "textPosition" : { "x" : 1072, "y" : 293 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1167, "y" : 293 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1167, "y" : 293 } } }, "connectors" : [ { "edgeId" : 74320, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1155, "y" : 318 }, "to" : { "x" : 1209, "y" : 331 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 74325, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1116, "y" : 290 }, "to" : { "x" : 1115, "y" : 274 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 74323, "reactomeId" : 10017686, "displayName" : "MYLK:Ca2+:CALM1", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 1214, "y" : 421 }, "minX" : 1167, "maxX" : 1268, "minY" : 396, "maxY" : 440, "prop" : { "x" : 1167, "y" : 402, "width" : 95, "height" : 38 }, "textPosition" : { "x" : 1174, "y" : 405 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1262, "y" : 402 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1262, "y" : 402 } } }, "connectors" : [ { "edgeId" : 74320, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 74322, "reactomeId" : 2025905, "displayName" : "Calmodulin:Calcium", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 1244, "y" : 289 }, "minX" : 1194, "maxX" : 1301, "minY" : 272, "maxY" : 331, "prop" : { "x" : 1194, "y" : 278, "width" : 101, "height" : 22 }, "textPosition" : { "x" : 1204, "y" : 265 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1295, "y" : 278 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1295, "y" : 278 } } }, "connectors" : [ { "edgeId" : 74320, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1234, "y" : 303 }, "to" : { "x" : 1209, "y" : 331 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 74324, "reactomeId" : 10017688, "displayName" : "p-S,T-PAK1,2", "schemaClass" : "CandidateSet", "renderableClass" : "EntitySet", "position" : { "x" : 857, "y" : 212 }, "minX" : 811, "maxX" : 1337, "minY" : 108, "maxY" : 362, "prop" : { "x" : 811, "y" : 201, "width" : 92, "height" : 22 }, "textPosition" : { "x" : 814, "y" : 201 }, "connectors" : [ { "edgeId" : 74320, "type" : "INHIBITOR", "segments" : [ { "from" : { "x" : 857, "y" : 195 }, "to" : { "x" : 858, "y" : 108 } }, { "from" : { "x" : 858, "y" : 108 }, "to" : { "x" : 1337, "y" : 111 } }, { "from" : { "x" : 1337, "y" : 111 }, "to" : { "x" : 1337, "y" : 353 } }, { "from" : { "x" : 1337, "y" : 353 }, "to" : { "x" : 1219, "y" : 358 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1219, "y" : 354 }, "b" : { "x" : 1219, "y" : 362 }, "c" : { "x" : 1219, "y" : 358 }, "type" : "STOP", "centre" : { "x" : 1219, "y" : 358 } } }, { "edgeId" : 74325, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 909, "y" : 218 }, "to" : { "x" : 1099, "y" : 248 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 1103, "y" : 248 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1103, "y" : 248 } } } ] }, { "id" : 74327, "reactomeId" : 10059164, "displayName" : "phospho-p-S1208,S1759-MYLK(1-1914)", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 1106, "y" : 171 }, "minX" : 1040, "maxX" : 1178, "minY" : 145, "maxY" : 219, "prop" : { "x" : 1040, "y" : 151, "width" : 132, "height" : 41 }, "textPosition" : { "x" : 1044, "y" : 147 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1172, "y" : 151 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1172, "y" : 151 } } }, "connectors" : [ { "edgeId" : 74325, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 1109, "y" : 195 }, "to" : { "x" : 1115, "y" : 219 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1115, "y" : 201 }, "b" : { "x" : 1109, "y" : 195 }, "c" : { "x" : 1107, "y" : 203 }, "type" : "ARROW", "centre" : { "x" : 1107, "y" : 203 } } } ] }, { "id" : 74326, "reactomeId" : 113592, "displayName" : "ATP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1164, "y" : 270 }, "minX" : 1115, "maxX" : 1186, "minY" : 257, "maxY" : 282, "prop" : { "x" : 1143, "y" : 258, "width" : 42, "height" : 24 }, "textPosition" : { "x" : 1148, "y" : 259 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1180, "y" : 263 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1180, "y" : 263 } } }, "connectors" : [ { "edgeId" : 74325, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1140, "y" : 271 }, "to" : { "x" : 1115, "y" : 274 } } ], "stoichiometry" : { "value" : 2, "shape" : { "a" : { "x" : 1121, "y" : 266 }, "b" : { "x" : 1133, "y" : 278 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1127, "y" : 272 } } } } ] }, { "id" : 74328, "reactomeId" : 29370, "displayName" : "ADP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1183, "y" : 219 }, "minX" : 1115, "maxX" : 1205, "minY" : 206, "maxY" : 232, "prop" : { "x" : 1162, "y" : 207, "width" : 42, "height" : 25 }, "textPosition" : { "x" : 1166, "y" : 209 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1199, "y" : 212 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1199, "y" : 212 } } }, "connectors" : [ { "edgeId" : 74325, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 1159, "y" : 219 }, "to" : { "x" : 1115, "y" : 219 } } ], "stoichiometry" : { "value" : 2, "shape" : { "a" : { "x" : 1131, "y" : 213 }, "b" : { "x" : 1143, "y" : 225 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1137, "y" : 219 } } }, "endShape" : { "a" : { "x" : 1152, "y" : 223 }, "b" : { "x" : 1159, "y" : 219 }, "c" : { "x" : 1152, "y" : 215 }, "type" : "ARROW", "centre" : { "x" : 1152, "y" : 215 } } } ] }, { "id" : 74331, "reactomeId" : 10040785, "displayName" : "Nf2", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 42, "y" : 252 }, "minX" : 0, "maxX" : 264, "minY" : 200, "maxY" : 388, "prop" : { "x" : 26, "y" : 241, "width" : 32, "height" : 22 }, "textPosition" : { "x" : 27, "y" : 241 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 58, "y" : 241 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 58, "y" : 241 } } }, "connectors" : [ { "edgeId" : 74340, "type" : "INHIBITOR", "segments" : [ { "from" : { "x" : 23, "y" : 251 }, "to" : { "x" : 1, "y" : 251 } }, { "from" : { "x" : 1, "y" : 251 }, "to" : { "x" : 0, "y" : 388 } }, { "from" : { "x" : 0, "y" : 388 }, "to" : { "x" : 238, "y" : 376 } }, { "from" : { "x" : 238, "y" : 376 }, "to" : { "x" : 260, "y" : 200 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 256, "y" : 200 }, "b" : { "x" : 264, "y" : 200 }, "c" : { "x" : 260, "y" : 200 }, "type" : "STOP", "centre" : { "x" : 260, "y" : 200 } } }, { "edgeId" : 74329, "type" : "INPUT", "segments" : [ { "from" : { "x" : 61, "y" : 258 }, "to" : { "x" : 108, "y" : 280 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 74330, "reactomeId" : 10012895, "displayName" : "PAK1 dimer", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 175, "y" : 280 }, "minX" : 108, "maxX" : 220, "minY" : 185, "maxY" : 291, "prop" : { "x" : 136, "y" : 269, "width" : 78, "height" : 22 }, "textPosition" : { "x" : 136, "y" : 270 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 214, "y" : 269 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 214, "y" : 269 } } }, "connectors" : [ { "edgeId" : 74340, "type" : "INPUT", "segments" : [ { "from" : { "x" : 179, "y" : 266 }, "to" : { "x" : 210, "y" : 185 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 74329, "type" : "INPUT", "segments" : [ { "from" : { "x" : 133, "y" : 280 }, "to" : { "x" : 108, "y" : 280 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 74332, "reactomeId" : 10059221, "displayName" : "PAK1:NF2", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 52, "y" : 338 }, "minX" : 18, "maxX" : 92, "minY" : 321, "maxY" : 349, "prop" : { "x" : 18, "y" : 327, "width" : 68, "height" : 22 }, "textPosition" : { "x" : 18, "y" : 328 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 86, "y" : 327 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 86, "y" : 327 } } }, "connectors" : [ { "edgeId" : 74329, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 74335, "reactomeId" : 10059227, "displayName" : "p-S144,T423-PAK1:FLNA", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 642, "y" : 679 }, "minX" : 594, "maxX" : 697, "minY" : 655, "maxY" : 753, "prop" : { "x" : 594, "y" : 661, "width" : 97, "height" : 36 }, "textPosition" : { "x" : 597, "y" : 662 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 691, "y" : 661 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 691, "y" : 661 } } }, "connectors" : [ { "edgeId" : 74336, "type" : "INPUT", "segments" : [ { "from" : { "x" : 644, "y" : 700 }, "to" : { "x" : 648, "y" : 731 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 74336, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 654, "y" : 700 }, "to" : { "x" : 681, "y" : 734 } }, { "from" : { "x" : 681, "y" : 734 }, "to" : { "x" : 662, "y" : 747 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 659, "y" : 749 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 659, "y" : 749 } } }, { "edgeId" : 74333, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 74334, "reactomeId" : 10059225, "displayName" : "FLNA", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 582, "y" : 549 }, "minX" : 563, "maxX" : 632, "minY" : 532, "maxY" : 560, "prop" : { "x" : 563, "y" : 538, "width" : 38, "height" : 22 }, "textPosition" : { "x" : 563, "y" : 539 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 601, "y" : 538 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 601, "y" : 538 } } }, "connectors" : [ { "edgeId" : 74333, "type" : "INPUT", "segments" : [ { "from" : { "x" : 604, "y" : 551 }, "to" : { "x" : 632, "y" : 555 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 74337, "reactomeId" : 113592, "displayName" : "ATP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 566, "y" : 724 }, "minX" : 544, "maxX" : 648, "minY" : 710, "maxY" : 737, "prop" : { "x" : 544, "y" : 711, "width" : 45, "height" : 26 }, "textPosition" : { "x" : 551, "y" : 713 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 584, "y" : 716 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 584, "y" : 716 } } }, "connectors" : [ { "edgeId" : 74336, "type" : "INPUT", "segments" : [ { "from" : { "x" : 592, "y" : 725 }, "to" : { "x" : 648, "y" : 731 } } ], "stoichiometry" : { "value" : 2, "shape" : { "a" : { "x" : 614, "y" : 722 }, "b" : { "x" : 626, "y" : 734 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 620, "y" : 728 } } } } ] }, { "id" : 74339, "reactomeId" : 10059234, "displayName" : "p-S2152-FLNA", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 649, "y" : 821 }, "minX" : 600, "maxX" : 704, "minY" : 781, "maxY" : 832, "prop" : { "x" : 600, "y" : 810, "width" : 98, "height" : 22 }, "textPosition" : { "x" : 602, "y" : 811 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 698, "y" : 810 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 698, "y" : 810 } } }, "connectors" : [ { "edgeId" : 74336, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 648, "y" : 807 }, "to" : { "x" : 648, "y" : 781 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 644, "y" : 800 }, "b" : { "x" : 648, "y" : 807 }, "c" : { "x" : 652, "y" : 800 }, "type" : "ARROW", "centre" : { "x" : 652, "y" : 800 } } } ] }, { "id" : 74338, "reactomeId" : 29370, "displayName" : "ADP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 557, "y" : 770 }, "minX" : 535, "maxX" : 648, "minY" : 758, "maxY" : 782, "prop" : { "x" : 535, "y" : 759, "width" : 44, "height" : 23 }, "textPosition" : { "x" : 540, "y" : 760 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 574, "y" : 764 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 574, "y" : 764 } } }, "connectors" : [ { "edgeId" : 74336, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 582, "y" : 772 }, "to" : { "x" : 648, "y" : 781 } } ], "stoichiometry" : { "value" : 2, "shape" : { "a" : { "x" : 609, "y" : 770 }, "b" : { "x" : 621, "y" : 782 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 615, "y" : 776 } } }, "endShape" : { "a" : { "x" : 589, "y" : 769 }, "b" : { "x" : 582, "y" : 772 }, "c" : { "x" : 588, "y" : 777 }, "type" : "ARROW", "centre" : { "x" : 588, "y" : 777 } } } ] }, { "id" : 74341, "reactomeId" : 10012893, "displayName" : "PAK1", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 336, "y" : 245 }, "minX" : 308, "maxX" : 362, "minY" : 188, "maxY" : 256, "prop" : { "x" : 316, "y" : 234, "width" : 40, "height" : 22 }, "textPosition" : { "x" : 316, "y" : 234 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 356, "y" : 234 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 356, "y" : 234 } } }, "connectors" : [ { "edgeId" : 74340, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 330, "y" : 231 }, "to" : { "x" : 308, "y" : 188 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 323, "y" : 227 }, "b" : { "x" : 330, "y" : 231 }, "c" : { "x" : 330, "y" : 223 }, "type" : "ARROW", "centre" : { "x" : 330, "y" : 223 } } } ] }, { "id" : 74342, "reactomeId" : 10040771, "displayName" : "RAC1:GTP,CDC42:GTP:PAK1", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 424, "y" : 126 }, "minX" : 308, "maxX" : 489, "minY" : 102, "maxY" : 188, "prop" : { "x" : 365, "y" : 108, "width" : 118, "height" : 36 }, "textPosition" : { "x" : 365, "y" : 109 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 483, "y" : 108 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 483, "y" : 108 } } }, "connectors" : [ { "edgeId" : 74340, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 362, "y" : 124 }, "to" : { "x" : 341, "y" : 124 } }, { "from" : { "x" : 341, "y" : 124 }, "to" : { "x" : 308, "y" : 188 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 355, "y" : 128 }, "b" : { "x" : 362, "y" : 124 }, "c" : { "x" : 355, "y" : 120 }, "type" : "ARROW", "centre" : { "x" : 355, "y" : 120 } } } ] }, { "id" : 74345, "reactomeId" : 10012899, "displayName" : "PAK2", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 375, "y" : 215 }, "minX" : 303, "maxX" : 402, "minY" : 163, "maxY" : 226, "prop" : { "x" : 354, "y" : 204, "width" : 42, "height" : 22 }, "textPosition" : { "x" : 355, "y" : 204 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 396, "y" : 204 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 396, "y" : 204 } } }, "connectors" : [ { "edgeId" : 74343, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 359, "y" : 201 }, "to" : { "x" : 303, "y" : 163 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 351, "y" : 200 }, "b" : { "x" : 359, "y" : 201 }, "c" : { "x" : 356, "y" : 194 }, "type" : "ARROW", "centre" : { "x" : 356, "y" : 194 } } } ] }, { "id" : 74344, "reactomeId" : 10012901, "displayName" : "PAK2 dimer", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 144, "y" : 238 }, "minX" : 106, "maxX" : 205, "minY" : 161, "maxY" : 250, "prop" : { "x" : 106, "y" : 227, "width" : 77, "height" : 23 }, "textPosition" : { "x" : 123, "y" : 215 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 183, "y" : 227 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 183, "y" : 227 } } }, "connectors" : [ { "edgeId" : 74343, "type" : "INPUT", "segments" : [ { "from" : { "x" : 153, "y" : 224 }, "to" : { "x" : 205, "y" : 161 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 74346, "reactomeId" : 10057122, "displayName" : "CDC42:GTP,RAC1:GTP:PAK2", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 420, "y" : 78 }, "minX" : 303, "maxX" : 485, "minY" : 54, "maxY" : 163, "prop" : { "x" : 361, "y" : 60, "width" : 118, "height" : 36 }, "textPosition" : { "x" : 361, "y" : 61 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 479, "y" : 60 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 479, "y" : 60 } } }, "connectors" : [ { "edgeId" : 74343, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 358, "y" : 85 }, "to" : { "x" : 336, "y" : 89 } }, { "from" : { "x" : 336, "y" : 89 }, "to" : { "x" : 303, "y" : 163 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 352, "y" : 90 }, "b" : { "x" : 358, "y" : 85 }, "c" : { "x" : 350, "y" : 82 }, "type" : "ARROW", "centre" : { "x" : 350, "y" : 82 } } } ] }, { "id" : 74349, "reactomeId" : 10057124, "displayName" : "CDC42:GTP,RAC1:GTP:PAK3", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 419, "y" : 36 }, "minX" : 291, "maxX" : 484, "minY" : 12, "maxY" : 134, "prop" : { "x" : 360, "y" : 18, "width" : 118, "height" : 36 }, "textPosition" : { "x" : 360, "y" : 19 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 478, "y" : 18 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 478, "y" : 18 } } }, "connectors" : [ { "edgeId" : 74347, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 357, "y" : 46 }, "to" : { "x" : 320, "y" : 53 } }, { "from" : { "x" : 320, "y" : 53 }, "to" : { "x" : 291, "y" : 134 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 351, "y" : 51 }, "b" : { "x" : 357, "y" : 46 }, "c" : { "x" : 349, "y" : 43 }, "type" : "ARROW", "centre" : { "x" : 349, "y" : 43 } } } ] }, { "id" : 74348, "reactomeId" : 10012904, "displayName" : "PAK3 dimer", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 116, "y" : 201 }, "minX" : 76, "maxX" : 220, "minY" : 137, "maxY" : 212, "prop" : { "x" : 76, "y" : 190, "width" : 81, "height" : 22 }, "textPosition" : { "x" : 77, "y" : 191 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 157, "y" : 190 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 157, "y" : 190 } } }, "connectors" : [ { "edgeId" : 74347, "type" : "INPUT", "segments" : [ { "from" : { "x" : 133, "y" : 187 }, "to" : { "x" : 220, "y" : 137 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 74350, "reactomeId" : 442833, "displayName" : "Pak3", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 405, "y" : 181 }, "minX" : 291, "maxX" : 431, "minY" : 134, "maxY" : 192, "prop" : { "x" : 385, "y" : 170, "width" : 40, "height" : 22 }, "textPosition" : { "x" : 385, "y" : 170 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 425, "y" : 170 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 425, "y" : 170 } } }, "connectors" : [ { "edgeId" : 74347, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 382, "y" : 172 }, "to" : { "x" : 291, "y" : 134 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 374, "y" : 173 }, "b" : { "x" : 382, "y" : 172 }, "c" : { "x" : 377, "y" : 166 }, "type" : "ARROW", "centre" : { "x" : 377, "y" : 166 } } } ] }, { "id" : 74353, "reactomeId" : 10099705, "displayName" : "Fcgamma receptor (FCGR) dependent phagocytosis", "schemaClass" : "Pathway", "renderableClass" : "EncapsulatedNode", "position" : { "x" : 344, "y" : 507 }, "minX" : 265, "maxX" : 424, "minY" : 473, "maxY" : 542, "prop" : { "x" : 265, "y" : 473, "width" : 159, "height" : 69 }, "textPosition" : { "x" : 275, "y" : 479 }, "connectors" : [ ] }, { "id" : 74352, "reactomeId" : 10100225, "displayName" : "RHO GTPases Activate ROCKs", "schemaClass" : "Pathway", "renderableClass" : "EncapsulatedNode", "position" : { "x" : 542, "y" : 611 }, "minX" : 481, "maxX" : 604, "minY" : 583, "maxY" : 640, "prop" : { "x" : 481, "y" : 583, "width" : 123, "height" : 57 }, "textPosition" : { "x" : 488, "y" : 590 }, "connectors" : [ ] }, { "id" : 74299, "reactomeId" : 10057126, "displayName" : "CDC42:GTP,RAC1:GTP:PAK1,PAK2,PAK3", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 629, "y" : 46 }, "minX" : 556, "maxX" : 703, "minY" : 19, "maxY" : 143, "prop" : { "x" : 556, "y" : 19, "width" : 147, "height" : 54 }, "textPosition" : { "x" : 557, "y" : 28 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "fgColor" : { "r" : 0, "g" : 0, "b" : 0 }, "connectors" : [ { "edgeId" : 74297, "type" : "INPUT", "segments" : [ { "from" : { "x" : 631, "y" : 79 }, "to" : { "x" : 634, "y" : 105 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 74297, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 646, "y" : 79 }, "to" : { "x" : 663, "y" : 99 } }, { "from" : { "x" : 663, "y" : 99 }, "to" : { "x" : 640, "y" : 135 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 638, "y" : 139 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 638, "y" : 139 } } } ] }, { "id" : 74298, "reactomeId" : 113592, "displayName" : "ATP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 575, "y" : 109 }, "minX" : 555, "maxX" : 634, "minY" : 93, "maxY" : 124, "prop" : { "x" : 555, "y" : 94, "width" : 40, "height" : 30 }, "textPosition" : { "x" : 559, "y" : 98 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 590, "y" : 99 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 590, "y" : 99 } } }, "connectors" : [ { "edgeId" : 74297, "type" : "INPUT", "segments" : [ { "from" : { "x" : 598, "y" : 107 }, "to" : { "x" : 634, "y" : 105 } } ], "stoichiometry" : { "value" : 2, "shape" : { "a" : { "x" : 610, "y" : 100 }, "b" : { "x" : 622, "y" : 112 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 616, "y" : 106 } } } } ] }, { "id" : 74301, "reactomeId" : 10013737, "displayName" : "p-S,T-PAK1,2,3", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 629, "y" : 225 }, "minX" : 575, "maxX" : 683, "minY" : 185, "maxY" : 236, "prop" : { "x" : 575, "y" : 214, "width" : 108, "height" : 22 }, "textPosition" : { "x" : 580, "y" : 214 }, "connectors" : [ { "edgeId" : 74297, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 628, "y" : 208 }, "to" : { "x" : 627, "y" : 185 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 624, "y" : 201 }, "b" : { "x" : 628, "y" : 208 }, "c" : { "x" : 632, "y" : 201 }, "type" : "ARROW", "centre" : { "x" : 632, "y" : 201 } } } ] }, { "id" : 74300, "reactomeId" : 29370, "displayName" : "ADP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 560, "y" : 154 }, "minX" : 540, "maxX" : 627, "minY" : 138, "maxY" : 185, "prop" : { "x" : 540, "y" : 139, "width" : 40, "height" : 30 }, "textPosition" : { "x" : 543, "y" : 143 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 575, "y" : 144 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 575, "y" : 144 } } }, "connectors" : [ { "edgeId" : 74297, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 583, "y" : 163 }, "to" : { "x" : 627, "y" : 185 } } ], "stoichiometry" : { "value" : 2, "shape" : { "a" : { "x" : 599, "y" : 168 }, "b" : { "x" : 611, "y" : 180 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 605, "y" : 174 } } }, "endShape" : { "a" : { "x" : 591, "y" : 163 }, "b" : { "x" : 583, "y" : 163 }, "c" : { "x" : 587, "y" : 170 }, "type" : "ARROW", "centre" : { "x" : 587, "y" : 170 } } } ] }, { "id" : 74302, "reactomeId" : 10012889, "displayName" : "CDC42:GTP, RAC1:GTP", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 106, "y" : 146 }, "minX" : 66, "maxX" : 716, "minY" : 0, "maxY" : 185, "prop" : { "x" : 66, "y" : 125, "width" : 81, "height" : 42 }, "textPosition" : { "x" : 64, "y" : 128 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "fgColor" : { "r" : 0, "g" : 0, "b" : 0 }, "connectors" : [ { "edgeId" : 74340, "type" : "INPUT", "segments" : [ { "from" : { "x" : 153, "y" : 161 }, "to" : { "x" : 210, "y" : 185 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 74343, "type" : "INPUT", "segments" : [ { "from" : { "x" : 153, "y" : 152 }, "to" : { "x" : 205, "y" : 161 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 74297, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 105, "y" : 119 }, "to" : { "x" : 103, "y" : 3 } }, { "from" : { "x" : 103, "y" : 3 }, "to" : { "x" : 716, "y" : 0 } }, { "from" : { "x" : 716, "y" : 0 }, "to" : { "x" : 712, "y" : 180 } }, { "from" : { "x" : 712, "y" : 180 }, "to" : { "x" : 627, "y" : 185 } } ], "stoichiometry" : { "value" : 3, "shape" : { "a" : { "x" : 98, "y" : 55 }, "b" : { "x" : 110, "y" : 67 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 104, "y" : 61 } } }, "endShape" : { "a" : { "x" : 101, "y" : 112 }, "b" : { "x" : 105, "y" : 119 }, "c" : { "x" : 109, "y" : 112 }, "type" : "ARROW", "centre" : { "x" : 109, "y" : 112 } } }, { "edgeId" : 74347, "type" : "INPUT", "segments" : [ { "from" : { "x" : 153, "y" : 142 }, "to" : { "x" : 220, "y" : 137 } } ], "stoichiometry" : { "value" : 1 } } ] } ], "edges" : [ { "id" : 74320, "reactomeId" : 10017690, "displayName" : "MYLK (MLCK) Active Calmodulin Binding", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 1210, "y" : 358 }, "minX" : 1204, "maxX" : 1216, "minY" : 331, "maxY" : 399, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 1209, "y" : 331 }, "to" : { "x" : 1210, "y" : 358 } }, { "from" : { "x" : 1210, "y" : 358 }, "to" : { "x" : 1212, "y" : 399 } } ], "endShape" : { "a" : { "x" : 1208, "y" : 392 }, "b" : { "x" : 1212, "y" : 399 }, "c" : { "x" : 1216, "y" : 392 }, "type" : "ARROW", "centre" : { "x" : 1216, "y" : 392 } }, "reactionShape" : { "c" : { "x" : 1210, "y" : 358 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 1210, "y" : 358 } }, "inputs" : [ { "id" : 74321, "points" : [ { "x" : 1155, "y" : 318 } ] }, { "id" : 74322, "points" : [ { "x" : 1234, "y" : 303 } ] } ], "outputs" : [ { "id" : 74323 } ], "inhibitors" : [ { "id" : 74324, "points" : [ { "x" : 857, "y" : 195 }, { "x" : 858, "y" : 108 }, { "x" : 1337, "y" : 111 }, { "x" : 1337, "y" : 353 } ] } ] }, { "id" : 74336, "reactomeId" : 10059237, "displayName" : "PAK1 phosphorylates FLNA", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 649, "y" : 756 }, "minX" : 643, "maxX" : 655, "minY" : 731, "maxY" : 781, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 648, "y" : 731 }, "to" : { "x" : 649, "y" : 756 } }, { "from" : { "x" : 649, "y" : 756 }, "to" : { "x" : 648, "y" : 781 } } ], "reactionShape" : { "a" : { "x" : 643, "y" : 750 }, "b" : { "x" : 655, "y" : 762 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 649, "y" : 756 } }, "inputs" : [ { "id" : 74337, "points" : [ { "x" : 592, "y" : 725 } ], "stoichiometry" : 2 }, { "id" : 74335, "points" : [ { "x" : 644, "y" : 700 } ] } ], "outputs" : [ { "id" : 74308, "points" : [ { "x" : 642, "y" : 320 }, { "x" : 762, "y" : 699 } ] }, { "id" : 74338, "points" : [ { "x" : 582, "y" : 772 } ], "stoichiometry" : 2 }, { "id" : 74339, "points" : [ { "x" : 648, "y" : 807 } ] } ], "catalysts" : [ { "id" : 74335, "points" : [ { "x" : 654, "y" : 700 }, { "x" : 681, "y" : 734 } ] } ] }, { "id" : 74309, "reactomeId" : 10059147, "displayName" : "PAK2 phosphorylates myosin regulatory light chain (MRLC)", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 943, "y" : 370 }, "minX" : 912, "maxX" : 964, "minY" : 364, "maxY" : 376, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 912, "y" : 370 }, "to" : { "x" : 943, "y" : 370 } }, { "from" : { "x" : 943, "y" : 370 }, "to" : { "x" : 964, "y" : 370 } } ], "reactionShape" : { "a" : { "x" : 937, "y" : 364 }, "b" : { "x" : 949, "y" : 376 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 943, "y" : 370 } }, "inputs" : [ { "id" : 74310, "points" : [ { "x" : 887, "y" : 371 } ] }, { "id" : 74311, "points" : [ { "x" : 903, "y" : 341 } ] } ], "outputs" : [ { "id" : 74312, "points" : [ { "x" : 981, "y" : 342 } ] }, { "id" : 74313, "points" : [ { "x" : 1012, "y" : 370 } ] } ], "catalysts" : [ { "id" : 74314, "points" : [ { "x" : 940, "y" : 290 } ] } ] }, { "id" : 74325, "reactomeId" : 10059167, "displayName" : "PAK1 or PAK2 phosphorylates MYLK", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 1115, "y" : 250 }, "minX" : 1109, "maxX" : 1121, "minY" : 219, "maxY" : 274, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 1115, "y" : 274 }, "to" : { "x" : 1115, "y" : 250 } }, { "from" : { "x" : 1115, "y" : 250 }, "to" : { "x" : 1115, "y" : 219 } } ], "reactionShape" : { "a" : { "x" : 1109, "y" : 244 }, "b" : { "x" : 1121, "y" : 256 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1115, "y" : 250 } }, "inputs" : [ { "id" : 74321, "points" : [ { "x" : 1116, "y" : 290 } ] }, { "id" : 74326, "points" : [ { "x" : 1140, "y" : 271 } ], "stoichiometry" : 2 } ], "outputs" : [ { "id" : 74327, "points" : [ { "x" : 1109, "y" : 195 } ] }, { "id" : 74328, "points" : [ { "x" : 1159, "y" : 219 } ], "stoichiometry" : 2 } ], "catalysts" : [ { "id" : 74324, "points" : [ { "x" : 909, "y" : 218 } ] } ] }, { "id" : 74340, "reactomeId" : 10040787, "displayName" : "RAC1 and CDC42 activate PAK1", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 261, "y" : 191 }, "minX" : 210, "maxX" : 308, "minY" : 185, "maxY" : 197, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 210, "y" : 185 }, "to" : { "x" : 261, "y" : 191 } }, { "from" : { "x" : 261, "y" : 191 }, "to" : { "x" : 308, "y" : 188 } } ], "reactionShape" : { "a" : { "x" : 255, "y" : 185 }, "b" : { "x" : 267, "y" : 197 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 261, "y" : 191 } }, "inputs" : [ { "id" : 74302, "points" : [ { "x" : 153, "y" : 161 } ] }, { "id" : 74330, "points" : [ { "x" : 179, "y" : 266 } ] } ], "outputs" : [ { "id" : 74341, "points" : [ { "x" : 330, "y" : 231 } ] }, { "id" : 74342, "points" : [ { "x" : 362, "y" : 124 }, { "x" : 341, "y" : 124 } ] } ], "inhibitors" : [ { "id" : 74331, "points" : [ { "x" : 23, "y" : 251 }, { "x" : 1, "y" : 251 }, { "x" : 0, "y" : 388 }, { "x" : 238, "y" : 376 } ] } ] }, { "id" : 74343, "reactomeId" : 10084650, "displayName" : "RAC1 and CDC42 activate PAK2", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 264, "y" : 160 }, "minX" : 205, "maxX" : 303, "minY" : 154, "maxY" : 166, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 205, "y" : 161 }, "to" : { "x" : 264, "y" : 160 } }, { "from" : { "x" : 264, "y" : 160 }, "to" : { "x" : 303, "y" : 163 } } ], "reactionShape" : { "a" : { "x" : 258, "y" : 154 }, "b" : { "x" : 270, "y" : 166 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 264, "y" : 160 } }, "inputs" : [ { "id" : 74302, "points" : [ { "x" : 153, "y" : 152 } ] }, { "id" : 74344, "points" : [ { "x" : 153, "y" : 224 } ] } ], "outputs" : [ { "id" : 74345, "points" : [ { "x" : 359, "y" : 201 } ] }, { "id" : 74346, "points" : [ { "x" : 358, "y" : 85 }, { "x" : 336, "y" : 89 } ] } ] }, { "id" : 74297, "reactomeId" : 10057129, "displayName" : "Autophosphorylation of PAK1,2,3", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 632, "y" : 149 }, "minX" : 626, "maxX" : 638, "minY" : 105, "maxY" : 185, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 634, "y" : 105 }, "to" : { "x" : 632, "y" : 149 } }, { "from" : { "x" : 632, "y" : 149 }, "to" : { "x" : 627, "y" : 185 } } ], "reactionShape" : { "a" : { "x" : 626, "y" : 143 }, "b" : { "x" : 638, "y" : 155 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 632, "y" : 149 } }, "inputs" : [ { "id" : 74298, "points" : [ { "x" : 598, "y" : 107 } ], "stoichiometry" : 2 }, { "id" : 74299, "points" : [ { "x" : 631, "y" : 79 } ] } ], "outputs" : [ { "id" : 74300, "points" : [ { "x" : 583, "y" : 163 } ], "stoichiometry" : 2 }, { "id" : 74301, "points" : [ { "x" : 628, "y" : 208 } ] }, { "id" : 74302, "points" : [ { "x" : 105, "y" : 119 }, { "x" : 103, "y" : 3 }, { "x" : 716, "y" : 0 }, { "x" : 712, "y" : 180 } ], "stoichiometry" : 3 } ], "catalysts" : [ { "id" : 74299, "points" : [ { "x" : 646, "y" : 79 }, { "x" : 663, "y" : 99 } ] } ] }, { "id" : 74329, "reactomeId" : 10059223, "displayName" : "NF2 binds PAK1", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 93, "y" : 297 }, "minX" : 63, "maxX" : 108, "minY" : 280, "maxY" : 324, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 108, "y" : 280 }, "to" : { "x" : 93, "y" : 297 } }, { "from" : { "x" : 93, "y" : 297 }, "to" : { "x" : 63, "y" : 324 } } ], "endShape" : { "a" : { "x" : 65, "y" : 316 }, "b" : { "x" : 63, "y" : 324 }, "c" : { "x" : 71, "y" : 322 }, "type" : "ARROW", "centre" : { "x" : 71, "y" : 322 } }, "reactionShape" : { "c" : { "x" : 93, "y" : 297 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 93, "y" : 297 } }, "inputs" : [ { "id" : 74330, "points" : [ { "x" : 133, "y" : 280 } ] }, { "id" : 74331, "points" : [ { "x" : 61, "y" : 258 } ] } ], "outputs" : [ { "id" : 74332 } ] }, { "id" : 74347, "reactomeId" : 10084648, "displayName" : "RAC1 and CDC42 activate PAK3", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 263, "y" : 137 }, "minX" : 220, "maxX" : 291, "minY" : 131, "maxY" : 143, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 220, "y" : 137 }, "to" : { "x" : 263, "y" : 137 } }, { "from" : { "x" : 263, "y" : 137 }, "to" : { "x" : 291, "y" : 134 } } ], "reactionShape" : { "a" : { "x" : 257, "y" : 131 }, "b" : { "x" : 269, "y" : 143 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 263, "y" : 137 } }, "inputs" : [ { "id" : 74302, "points" : [ { "x" : 153, "y" : 142 } ] }, { "id" : 74348, "points" : [ { "x" : 133, "y" : 187 } ] } ], "outputs" : [ { "id" : 74349, "points" : [ { "x" : 357, "y" : 46 }, { "x" : 320, "y" : 53 } ] }, { "id" : 74350, "points" : [ { "x" : 382, "y" : 172 } ] } ] }, { "id" : 74315, "reactomeId" : 10059160, "displayName" : "PAK1 phosphorylates myosin phosphatase", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 874, "y" : 675 }, "minX" : 868, "maxX" : 880, "minY" : 652, "maxY" : 701, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 874, "y" : 652 }, "to" : { "x" : 874, "y" : 675 } }, { "from" : { "x" : 874, "y" : 675 }, "to" : { "x" : 875, "y" : 701 } } ], "reactionShape" : { "a" : { "x" : 868, "y" : 669 }, "b" : { "x" : 880, "y" : 681 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 874, "y" : 675 } }, "inputs" : [ { "id" : 74316, "points" : [ { "x" : 872, "y" : 630 } ] }, { "id" : 74317, "points" : [ { "x" : 919, "y" : 652 } ] } ], "outputs" : [ { "id" : 74318, "points" : [ { "x" : 912, "y" : 701 } ] }, { "id" : 74319, "points" : [ { "x" : 875, "y" : 736 } ] } ], "catalysts" : [ { "id" : 74308, "points" : [ { "x" : 706, "y" : 302 }, { "x" : 730, "y" : 303 }, { "x" : 772, "y" : 620 } ] } ] }, { "id" : 74333, "reactomeId" : 10059229, "displayName" : "FLNA binds PAK1", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 635, "y" : 584 }, "minX" : 629, "maxX" : 641, "minY" : 555, "maxY" : 658, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 632, "y" : 555 }, "to" : { "x" : 635, "y" : 584 } }, { "from" : { "x" : 635, "y" : 584 }, "to" : { "x" : 640, "y" : 658 } } ], "endShape" : { "a" : { "x" : 636, "y" : 651 }, "b" : { "x" : 640, "y" : 658 }, "c" : { "x" : 644, "y" : 651 }, "type" : "ARROW", "centre" : { "x" : 644, "y" : 651 } }, "reactionShape" : { "c" : { "x" : 635, "y" : 584 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 635, "y" : 584 } }, "inputs" : [ { "id" : 74308, "points" : [ { "x" : 637, "y" : 320 } ] }, { "id" : 74334, "points" : [ { "x" : 604, "y" : 551 } ] } ], "outputs" : [ { "id" : 74335 } ] }, { "id" : 74303, "reactomeId" : 10040802, "displayName" : "PAK1 phosphorylates LIMK1", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 539, "y" : 417 }, "minX" : 533, "maxX" : 545, "minY" : 388, "maxY" : 451, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 538, "y" : 388 }, "to" : { "x" : 539, "y" : 417 } }, { "from" : { "x" : 539, "y" : 417 }, "to" : { "x" : 540, "y" : 451 } } ], "reactionShape" : { "a" : { "x" : 533, "y" : 411 }, "b" : { "x" : 545, "y" : 423 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 539, "y" : 417 } }, "inputs" : [ { "id" : 74304, "points" : [ { "x" : 538, "y" : 356 } ] }, { "id" : 74305, "points" : [ { "x" : 564, "y" : 381 } ] } ], "outputs" : [ { "id" : 74306, "points" : [ { "x" : 541, "y" : 492 } ] }, { "id" : 74307, "points" : [ { "x" : 567, "y" : 455 } ] } ], "catalysts" : [ { "id" : 74308, "points" : [ { "x" : 634, "y" : 320 }, { "x" : 612, "y" : 409 } ] } ] } ], "compartments" : [ { "id" : 74351, "reactomeId" : 70101, "displayName" : "cytosol", "schemaClass" : "Compartment", "renderableClass" : "Compartment", "position" : { "x" : 704, "y" : 451 }, "minX" : 33, "maxX" : 1376, "minY" : 32, "maxY" : 870, "prop" : { "x" : 33, "y" : 32, "width" : 1343, "height" : 838 }, "textPosition" : { "x" : 54, "y" : 620 }, "insets" : { "x" : 43, "y" : 42, "width" : 1323, "height" : 818 }, "bgColor" : { "r" : 250, "g" : 240, "b" : 240 }, "componentIds" : [ 74302, 74297, 74301, 74303, 74304, 74305, 74360, 74306, 74307, 74308, 74352, 74361, 74353, 74362, 74310, 74311, 74312, 74363, 74309, 74313, 74314, 74316, 74315, 74317, 74318, 74319, 74320, 74321, 74322, 74323, 74325, 74326, 74324, 74364, 74365, 74366, 74327, 74328, 74329, 74330, 74331, 74332, 74333, 74335, 74334, 74336, 74337, 74339, 74338, 74340, 74341, 74342, 74343, 74344, 74345, 74346, 74347, 74348, 74349, 74350, 74299, 74367, 74368, 74369, 74298, 74300 ] } ], "notes" : [ ], "links" : [ { "id" : 74369, "renderableClass" : "EntitySetAndMemberLink", "position" : { "x" : 515, "y" : 40 }, "minX" : 481, "maxX" : 550, "minY" : 34, "maxY" : 46, "segments" : [ { "from" : { "x" : 481, "y" : 38 }, "to" : { "x" : 550, "y" : 42 } } ], "reactionShape" : { "a" : { "x" : 509, "y" : 34 }, "b" : { "x" : 521, "y" : 46 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 515, "y" : 40 } }, "inputs" : [ { "id" : 74349 } ], "outputs" : [ { "id" : 74299 } ] }, { "id" : 74368, "renderableClass" : "EntitySetAndMemberLink", "position" : { "x" : 516, "y" : 62 }, "minX" : 482, "maxX" : 550, "minY" : 56, "maxY" : 68, "segments" : [ { "from" : { "x" : 482, "y" : 68 }, "to" : { "x" : 550, "y" : 57 } } ], "reactionShape" : { "a" : { "x" : 510, "y" : 56 }, "b" : { "x" : 522, "y" : 68 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 516, "y" : 62 } }, "inputs" : [ { "id" : 74346 } ], "outputs" : [ { "id" : 74299 } ] }, { "id" : 74361, "renderableClass" : "Interaction", "position" : { "x" : 541, "y" : 550 }, "minX" : 535, "maxX" : 547, "minY" : 520, "maxY" : 580, "interactionType" : "Activate", "segments" : [ { "from" : { "x" : 541, "y" : 580 }, "to" : { "x" : 541, "y" : 520 } } ], "endShape" : { "a" : { "x" : 545, "y" : 527 }, "b" : { "x" : 541, "y" : 520 }, "c" : { "x" : 537, "y" : 527 }, "type" : "ARROW", "empty" : true, "centre" : { "x" : 537, "y" : 527 } }, "reactionShape" : { "a" : { "x" : 535, "y" : 544 }, "b" : { "x" : 547, "y" : 556 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 541, "y" : 550 } }, "inputs" : [ { "id" : 74352 } ], "outputs" : [ { "id" : 74306 } ] }, { "id" : 74360, "renderableClass" : "EntitySetAndMemberLink", "position" : { "x" : 633, "y" : 263 }, "minX" : 627, "maxX" : 639, "minY" : 242, "maxY" : 284, "segments" : [ { "from" : { "x" : 636, "y" : 284 }, "to" : { "x" : 630, "y" : 242 } } ], "reactionShape" : { "a" : { "x" : 627, "y" : 257 }, "b" : { "x" : 639, "y" : 269 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 633, "y" : 263 } }, "inputs" : [ { "id" : 74308 } ], "outputs" : [ { "id" : 74301 } ] }, { "id" : 74363, "renderableClass" : "EntitySetAndMemberLink", "position" : { "x" : 779, "y" : 247 }, "minX" : 689, "maxX" : 870, "minY" : 233, "maxY" : 261, "segments" : [ { "from" : { "x" : 870, "y" : 261 }, "to" : { "x" : 689, "y" : 233 } } ], "reactionShape" : { "a" : { "x" : 773, "y" : 241 }, "b" : { "x" : 785, "y" : 253 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 779, "y" : 247 } }, "inputs" : [ { "id" : 74314 } ], "outputs" : [ { "id" : 74301 } ] }, { "id" : 74362, "renderableClass" : "Interaction", "position" : { "x" : 458, "y" : 506 }, "minX" : 427, "maxX" : 490, "minY" : 500, "maxY" : 512, "interactionType" : "Activate", "segments" : [ { "from" : { "x" : 490, "y" : 506 }, "to" : { "x" : 427, "y" : 506 } } ], "endShape" : { "a" : { "x" : 434, "y" : 502 }, "b" : { "x" : 427, "y" : 506 }, "c" : { "x" : 434, "y" : 510 }, "type" : "ARROW", "empty" : true, "centre" : { "x" : 434, "y" : 510 } }, "reactionShape" : { "a" : { "x" : 452, "y" : 500 }, "b" : { "x" : 464, "y" : 512 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 458, "y" : 506 } }, "inputs" : [ { "id" : 74306 } ], "outputs" : [ { "id" : 74353 } ] }, { "id" : 74365, "renderableClass" : "EntitySetAndMemberLink", "position" : { "x" : 894, "y" : 242 }, "minX" : 872, "maxX" : 917, "minY" : 229, "maxY" : 255, "segments" : [ { "from" : { "x" : 917, "y" : 255 }, "to" : { "x" : 872, "y" : 229 } } ], "reactionShape" : { "a" : { "x" : 888, "y" : 236 }, "b" : { "x" : 900, "y" : 248 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 894, "y" : 242 } }, "inputs" : [ { "id" : 74314 } ], "outputs" : [ { "id" : 74324 } ] }, { "id" : 74364, "renderableClass" : "EntitySetAndMemberLink", "position" : { "x" : 753, "y" : 256 }, "minX" : 677, "maxX" : 829, "minY" : 229, "maxY" : 284, "segments" : [ { "from" : { "x" : 677, "y" : 284 }, "to" : { "x" : 829, "y" : 229 } } ], "reactionShape" : { "a" : { "x" : 747, "y" : 250 }, "b" : { "x" : 759, "y" : 262 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 753, "y" : 256 } }, "inputs" : [ { "id" : 74308 } ], "outputs" : [ { "id" : 74324 } ] }, { "id" : 74367, "renderableClass" : "EntitySetAndMemberLink", "position" : { "x" : 508, "y" : 88 }, "minX" : 466, "maxX" : 550, "minY" : 72, "maxY" : 105, "segments" : [ { "from" : { "x" : 466, "y" : 105 }, "to" : { "x" : 550, "y" : 72 } } ], "reactionShape" : { "a" : { "x" : 502, "y" : 82 }, "b" : { "x" : 514, "y" : 94 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 508, "y" : 88 } }, "inputs" : [ { "id" : 74342 } ], "outputs" : [ { "id" : 74299 } ] }, { "id" : 74366, "renderableClass" : "EntitySetAndEntitySetLink", "position" : { "x" : 747, "y" : 217 }, "minX" : 689, "maxX" : 805, "minY" : 211, "maxY" : 223, "segments" : [ { "from" : { "x" : 805, "y" : 214 }, "to" : { "x" : 689, "y" : 221 } } ], "reactionShape" : { "a" : { "x" : 741, "y" : 211 }, "b" : { "x" : 753, "y" : 223 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 747, "y" : 217 } }, "inputs" : [ { "id" : 74324 } ], "outputs" : [ { "id" : 74301 } ] } ], "shadows" : [ ], "minX" : 0, "maxX" : 1376, "minY" : 0, "maxY" : 870, "disease" : false }