{
  "dbId" : 10099887,
  "stableId" : "R-MMU-211000",
  "displayName" : "Gene Silencing by RNA",
  "nodes" : [ {
    "id" : 50817,
    "reactomeId" : 10015560,
    "displayName" : "AGO2:siRNA",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 112,
      "y" : 866
    },
    "minX" : 67,
    "maxX" : 163,
    "minY" : 849,
    "maxY" : 878,
    "prop" : {
      "x" : 67,
      "y" : 855,
      "width" : 90,
      "height" : 23
    },
    "textPosition" : {
      "x" : 71,
      "y" : 857
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 157,
          "y" : 855
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 157,
          "y" : 855
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 50816,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 50818,
    "reactomeId" : 10086944,
    "displayName" : "C3PO",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 50,
      "y" : 767
    },
    "minX" : 17,
    "maxX" : 102,
    "minY" : 750,
    "maxY" : 779,
    "prop" : {
      "x" : 17,
      "y" : 756,
      "width" : 66,
      "height" : 23
    },
    "textPosition" : {
      "x" : 29,
      "y" : 758
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 83,
          "y" : 756
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 83,
          "y" : 756
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 50816,
      "type" : "CATALYST",
      "segments" : [ {
        "from" : {
          "x" : 86,
          "y" : 767
        },
        "to" : {
          "x" : 94,
          "y" : 767
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 98,
          "y" : 768
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 98,
          "y" : 768
        }
      }
    } ]
  }, {
    "id" : 50776,
    "reactomeId" : 10006611,
    "displayName" : "TARBP2,PRKRA:DICER1:Pre-RISC (miRNA)",
    "schemaClass" : "DefinedSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 636,
      "y" : 756
    },
    "minX" : 574,
    "maxX" : 698,
    "minY" : 730,
    "maxY" : 783,
    "prop" : {
      "x" : 574,
      "y" : 730,
      "width" : 124,
      "height" : 53
    },
    "textPosition" : {
      "x" : 580,
      "y" : 732
    },
    "connectors" : [ {
      "edgeId" : 50794,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 50775,
      "type" : "INPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 50777,
    "reactomeId" : 10006629,
    "displayName" : "TARBP2,PRKRA:DICER1:RISC (miRNA)",
    "schemaClass" : "DefinedSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 638,
      "y" : 874
    },
    "minX" : 581,
    "maxX" : 696,
    "minY" : 848,
    "maxY" : 900,
    "prop" : {
      "x" : 581,
      "y" : 848,
      "width" : 115,
      "height" : 52
    },
    "textPosition" : {
      "x" : 587,
      "y" : 849
    },
    "connectors" : [ {
      "edgeId" : 50775,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 50779,
    "reactomeId" : 426463,
    "displayName" : "Double-stranded RNA",
    "schemaClass" : "OtherEntity",
    "renderableClass" : "Entity",
    "position" : {
      "x" : 97,
      "y" : 542
    },
    "minX" : 25,
    "maxX" : 221,
    "minY" : 528,
    "maxY" : 562,
    "prop" : {
      "x" : 25,
      "y" : 528,
      "width" : 144,
      "height" : 29
    },
    "textPosition" : {
      "x" : 26,
      "y" : 532
    },
    "connectors" : [ {
      "edgeId" : 50778,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 172,
          "y" : 553
        },
        "to" : {
          "x" : 221,
          "y" : 562
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 50780,
    "reactomeId" : 10004966,
    "displayName" : "TARBP2,PRKRA RLC",
    "schemaClass" : "DefinedSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 407,
      "y" : 543
    },
    "minX" : 221,
    "maxX" : 478,
    "minY" : 528,
    "maxY" : 578,
    "prop" : {
      "x" : 337,
      "y" : 528,
      "width" : 141,
      "height" : 30
    },
    "textPosition" : {
      "x" : 345,
      "y" : 532
    },
    "connectors" : [ {
      "edgeId" : 50778,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 331,
          "y" : 550
        },
        "to" : {
          "x" : 221,
          "y" : 562
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 50778,
      "type" : "CATALYST",
      "segments" : [ {
        "from" : {
          "x" : 331,
          "y" : 557
        },
        "to" : {
          "x" : 255,
          "y" : 574
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 251,
          "y" : 574
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 251,
          "y" : 574
        }
      }
    } ]
  }, {
    "id" : 50781,
    "reactomeId" : 10015555,
    "displayName" : "TARBP2,PRKRA RLC:duplex siRNA",
    "schemaClass" : "DefinedSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 243,
      "y" : 643
    },
    "minX" : 178,
    "maxX" : 309,
    "minY" : 623,
    "maxY" : 663,
    "prop" : {
      "x" : 178,
      "y" : 623,
      "width" : 131,
      "height" : 40
    },
    "textPosition" : {
      "x" : 179,
      "y" : 625
    },
    "connectors" : [ {
      "edgeId" : 50796,
      "type" : "INPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 50778,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 50783,
    "reactomeId" : 426523,
    "displayName" : "RNA (exact match)",
    "schemaClass" : "OtherEntity",
    "renderableClass" : "Entity",
    "position" : {
      "x" : 322,
      "y" : 1037
    },
    "minX" : 260,
    "maxX" : 525,
    "minY" : 1022,
    "maxY" : 1090,
    "prop" : {
      "x" : 260,
      "y" : 1022,
      "width" : 124,
      "height" : 31
    },
    "textPosition" : {
      "x" : 260,
      "y" : 1027
    },
    "connectors" : [ {
      "edgeId" : 50791,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 381,
          "y" : 1056
        },
        "to" : {
          "x" : 525,
          "y" : 1090
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 50782,
      "type" : "INPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 50784,
    "reactomeId" : 426511,
    "displayName" : "Cleaved RNA with 5' Phosphate and 3' Hydroxyl",
    "schemaClass" : "OtherEntity",
    "renderableClass" : "Entity",
    "position" : {
      "x" : 192,
      "y" : 1216
    },
    "minX" : 33,
    "maxX" : 352,
    "minY" : 1134,
    "maxY" : 1233,
    "prop" : {
      "x" : 33,
      "y" : 1200,
      "width" : 319,
      "height" : 33
    },
    "textPosition" : {
      "x" : 42,
      "y" : 1206
    },
    "connectors" : [ {
      "edgeId" : 50782,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 2,
        "shape" : {
          "a" : {
            "x" : 185,
            "y" : 1134
          },
          "b" : {
            "x" : 197,
            "y" : 1146
          },
          "type" : "BOX",
          "empty" : true,
          "centre" : {
            "x" : 191,
            "y" : 1140
          }
        }
      }
    } ]
  }, {
    "id" : 50785,
    "reactomeId" : 10015562,
    "displayName" : "Endonucleolytic RISC",
    "schemaClass" : "DefinedSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 188,
      "y" : 986
    },
    "minX" : 91,
    "maxX" : 286,
    "minY" : 973,
    "maxY" : 1075,
    "prop" : {
      "x" : 91,
      "y" : 973,
      "width" : 195,
      "height" : 27
    },
    "textPosition" : {
      "x" : 120,
      "y" : 976
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "connectors" : [ {
      "edgeId" : 50782,
      "type" : "CATALYST",
      "segments" : [ {
        "from" : {
          "x" : 188,
          "y" : 1006
        },
        "to" : {
          "x" : 190,
          "y" : 1067
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 191,
          "y" : 1071
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 191,
          "y" : 1071
        }
      }
    } ]
  }, {
    "id" : 50787,
    "reactomeId" : 10015583,
    "displayName" : "TNRC6 (GW182)",
    "schemaClass" : "DefinedSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 650,
      "y" : 1014
    },
    "minX" : 525,
    "maxX" : 807,
    "minY" : 998,
    "maxY" : 1090,
    "prop" : {
      "x" : 580,
      "y" : 998,
      "width" : 140,
      "height" : 33
    },
    "textPosition" : {
      "x" : 597,
      "y" : 1004
    },
    "connectors" : [ {
      "edgeId" : 50786,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 689,
          "y" : 1037
        },
        "to" : {
          "x" : 807,
          "y" : 1079
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 50791,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 622,
          "y" : 1037
        },
        "to" : {
          "x" : 525,
          "y" : 1090
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 50788,
    "reactomeId" : 10015572,
    "displayName" : "RISC",
    "schemaClass" : "DefinedSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 464,
      "y" : 922
    },
    "minX" : 403,
    "maxX" : 807,
    "minY" : 910,
    "maxY" : 1079,
    "prop" : {
      "x" : 403,
      "y" : 910,
      "width" : 122,
      "height" : 24
    },
    "textPosition" : {
      "x" : 446,
      "y" : 911
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "connectors" : [ {
      "edgeId" : 50786,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 531,
          "y" : 925
        },
        "to" : {
          "x" : 796,
          "y" : 943
        }
      }, {
        "from" : {
          "x" : 796,
          "y" : 943
        },
        "to" : {
          "x" : 807,
          "y" : 1079
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 50789,
    "reactomeId" : 426515,
    "displayName" : "RNA (inexact match)",
    "schemaClass" : "OtherEntity",
    "renderableClass" : "Entity",
    "position" : {
      "x" : 890,
      "y" : 1034
    },
    "minX" : 807,
    "maxX" : 961,
    "minY" : 1020,
    "maxY" : 1079,
    "prop" : {
      "x" : 820,
      "y" : 1020,
      "width" : 141,
      "height" : 28
    },
    "textPosition" : {
      "x" : 823,
      "y" : 1023
    },
    "connectors" : [ {
      "edgeId" : 50786,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 864,
          "y" : 1051
        },
        "to" : {
          "x" : 807,
          "y" : 1079
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 50790,
    "reactomeId" : 10015585,
    "displayName" : "TNRC6:RISC:Target RNA (inexact match)",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 808,
      "y" : 1215
    },
    "minX" : 712,
    "maxX" : 911,
    "minY" : 1191,
    "maxY" : 1233,
    "prop" : {
      "x" : 712,
      "y" : 1197,
      "width" : 193,
      "height" : 36
    },
    "textPosition" : {
      "x" : 730,
      "y" : 1198
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 905,
          "y" : 1197
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 905,
          "y" : 1197
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 50786,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 50792,
    "reactomeId" : 10015570,
    "displayName" : "Nonendonucleolytic RISC",
    "schemaClass" : "DefinedSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 473,
      "y" : 988
    },
    "minX" : 386,
    "maxX" : 560,
    "minY" : 975,
    "maxY" : 1090,
    "prop" : {
      "x" : 386,
      "y" : 975,
      "width" : 174,
      "height" : 26
    },
    "textPosition" : {
      "x" : 392,
      "y" : 977
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "connectors" : [ {
      "edgeId" : 50791,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 479,
          "y" : 1007
        },
        "to" : {
          "x" : 525,
          "y" : 1090
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 50793,
    "reactomeId" : 10015592,
    "displayName" : "TNRC6:Nonendonucleolytic RISC:Target RNA (exact match)",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 526,
      "y" : 1213
    },
    "minX" : 370,
    "maxX" : 689,
    "minY" : 1189,
    "maxY" : 1232,
    "prop" : {
      "x" : 370,
      "y" : 1195,
      "width" : 313,
      "height" : 37
    },
    "textPosition" : {
      "x" : 384,
      "y" : 1197
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 683,
          "y" : 1195
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 683,
          "y" : 1195
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 50791,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 50795,
    "reactomeId" : 10041868,
    "displayName" : "TARBP2,PRKRA RLC:duplex miRNA",
    "schemaClass" : "DefinedSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 630,
      "y" : 637
    },
    "minX" : 565,
    "maxX" : 696,
    "minY" : 617,
    "maxY" : 658,
    "prop" : {
      "x" : 565,
      "y" : 617,
      "width" : 131,
      "height" : 41
    },
    "textPosition" : {
      "x" : 566,
      "y" : 620
    },
    "connectors" : [ {
      "edgeId" : 50794,
      "type" : "INPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 50797,
    "reactomeId" : 10041886,
    "displayName" : "TARBP2,PRKRA:DICER1:Pre-RISC (siRNA)",
    "schemaClass" : "DefinedSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 246,
      "y" : 758
    },
    "minX" : 185,
    "maxX" : 307,
    "minY" : 733,
    "maxY" : 783,
    "prop" : {
      "x" : 185,
      "y" : 733,
      "width" : 122,
      "height" : 50
    },
    "textPosition" : {
      "x" : 190,
      "y" : 733
    },
    "connectors" : [ {
      "edgeId" : 50796,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 50798,
      "type" : "INPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 50799,
    "reactomeId" : 10041894,
    "displayName" : "TARBP2,PRKRA:DICER1:RISC (siRNA)",
    "schemaClass" : "DefinedSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 246,
      "y" : 870
    },
    "minX" : 189,
    "maxX" : 303,
    "minY" : 847,
    "maxY" : 894,
    "prop" : {
      "x" : 189,
      "y" : 847,
      "width" : 114,
      "height" : 47
    },
    "textPosition" : {
      "x" : 195,
      "y" : 846
    },
    "connectors" : [ {
      "edgeId" : 50798,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 50801,
    "reactomeId" : 10006615,
    "displayName" : "AGO2:miRNA",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 820,
      "y" : 888
    },
    "minX" : 790,
    "maxX" : 1022,
    "minY" : 718,
    "maxY" : 907,
    "prop" : {
      "x" : 790,
      "y" : 870,
      "width" : 60,
      "height" : 37
    },
    "textPosition" : {
      "x" : 796,
      "y" : 872
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 850,
          "y" : 870
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 850,
          "y" : 870
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 50800,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 821,
          "y" : 867
        },
        "to" : {
          "x" : 837,
          "y" : 718
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 50808,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 853,
          "y" : 882
        },
        "to" : {
          "x" : 1022,
          "y" : 852
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 50802,
    "reactomeId" : 10055207,
    "displayName" : "Ipo8",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 894,
      "y" : 785
    },
    "minX" : 837,
    "maxX" : 928,
    "minY" : 718,
    "maxY" : 798,
    "prop" : {
      "x" : 866,
      "y" : 772,
      "width" : 56,
      "height" : 26
    },
    "textPosition" : {
      "x" : 876,
      "y" : 774
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 922,
          "y" : 772
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 922,
          "y" : 772
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 50800,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 882,
          "y" : 769
        },
        "to" : {
          "x" : 837,
          "y" : 718
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 50803,
    "reactomeId" : 10055209,
    "displayName" : "IPO8:AGO2:miRNA",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 839,
      "y" : 466
    },
    "minX" : 767,
    "maxX" : 918,
    "minY" : 365,
    "maxY" : 478,
    "prop" : {
      "x" : 767,
      "y" : 454,
      "width" : 145,
      "height" : 24
    },
    "textPosition" : {
      "x" : 781,
      "y" : 457
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 912,
          "y" : 454
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 912,
          "y" : 454
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 50800,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 50804,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 838,
          "y" : 451
        },
        "to" : {
          "x" : 836,
          "y" : 365
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 50805,
    "reactomeId" : 10055213,
    "displayName" : "RAN:GTP",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 751,
      "y" : 386
    },
    "minX" : 716,
    "maxX" : 836,
    "minY" : 365,
    "maxY" : 398,
    "prop" : {
      "x" : 716,
      "y" : 374,
      "width" : 71,
      "height" : 24
    },
    "textPosition" : {
      "x" : 721,
      "y" : 377
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 787,
          "y" : 374
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 787,
          "y" : 374
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 50804,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 790,
          "y" : 377
        },
        "to" : {
          "x" : 836,
          "y" : 365
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 50806,
    "reactomeId" : 10055219,
    "displayName" : "AGO2:miRNA",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 875,
      "y" : 271
    },
    "minX" : 821,
    "maxX" : 936,
    "minY" : 253,
    "maxY" : 307,
    "prop" : {
      "x" : 821,
      "y" : 259,
      "width" : 109,
      "height" : 25
    },
    "textPosition" : {
      "x" : 833,
      "y" : 263
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 930,
          "y" : 259
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 930,
          "y" : 259
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 50804,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 860,
          "y" : 287
        },
        "to" : {
          "x" : 834,
          "y" : 307
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 857,
          "y" : 294
        },
        "b" : {
          "x" : 860,
          "y" : 287
        },
        "c" : {
          "x" : 852,
          "y" : 288
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 852,
          "y" : 288
        }
      }
    } ]
  }, {
    "id" : 50807,
    "reactomeId" : 10055223,
    "displayName" : "IPO8:RAN:GTP",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 736,
      "y" : 256
    },
    "minX" : 679,
    "maxX" : 834,
    "minY" : 238,
    "maxY" : 307,
    "prop" : {
      "x" : 679,
      "y" : 244,
      "width" : 115,
      "height" : 25
    },
    "textPosition" : {
      "x" : 690,
      "y" : 248
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 794,
          "y" : 244
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 794,
          "y" : 244
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 50804,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 760,
          "y" : 272
        },
        "to" : {
          "x" : 834,
          "y" : 307
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 768,
          "y" : 271
        },
        "b" : {
          "x" : 760,
          "y" : 272
        },
        "c" : {
          "x" : 765,
          "y" : 279
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 765,
          "y" : 279
        }
      }
    } ]
  }, {
    "id" : 50809,
    "reactomeId" : 10015575,
    "displayName" : "Tnrc6a",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 1022,
      "y" : 954
    },
    "minX" : 985,
    "maxX" : 1065,
    "minY" : 852,
    "maxY" : 965,
    "prop" : {
      "x" : 985,
      "y" : 943,
      "width" : 74,
      "height" : 22
    },
    "textPosition" : {
      "x" : 996,
      "y" : 943
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1059,
          "y" : 943
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1059,
          "y" : 943
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 50808,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1022,
          "y" : 940
        },
        "to" : {
          "x" : 1022,
          "y" : 852
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 50810,
    "reactomeId" : 10055290,
    "displayName" : "TNRC6A:AGO2:miRNA",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 1021,
      "y" : 698
    },
    "minX" : 943,
    "maxX" : 1106,
    "minY" : 678,
    "maxY" : 712,
    "prop" : {
      "x" : 943,
      "y" : 684,
      "width" : 157,
      "height" : 28
    },
    "textPosition" : {
      "x" : 953,
      "y" : 691
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1100,
          "y" : 684
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1100,
          "y" : 684
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 50808,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 50811,
      "type" : "INPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 50812,
    "reactomeId" : 10055296,
    "displayName" : "TNRC6A:AGO2:miRNA",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 1023,
      "y" : 279
    },
    "minX" : 944,
    "maxX" : 1108,
    "minY" : 258,
    "maxY" : 295,
    "prop" : {
      "x" : 944,
      "y" : 264,
      "width" : 158,
      "height" : 31
    },
    "textPosition" : {
      "x" : 954,
      "y" : 274
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1102,
          "y" : 264
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1102,
          "y" : 264
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 50811,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 50814,
    "reactomeId" : 10041872,
    "displayName" : "AGO2:duplex siRNA",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 110,
      "y" : 579
    },
    "minX" : 37,
    "maxX" : 190,
    "minY" : 561,
    "maxY" : 628,
    "prop" : {
      "x" : 37,
      "y" : 567,
      "width" : 147,
      "height" : 25
    },
    "textPosition" : {
      "x" : 47,
      "y" : 571
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 184,
          "y" : 567
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 184,
          "y" : 567
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 50813,
      "type" : "INPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 50813,
      "type" : "CATALYST",
      "segments" : [ {
        "from" : {
          "x" : 109,
          "y" : 595
        },
        "to" : {
          "x" : 108,
          "y" : 620
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 108,
          "y" : 624
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 108,
          "y" : 624
        }
      }
    } ]
  }, {
    "id" : 50815,
    "reactomeId" : 10086934,
    "displayName" : "AGO2:cleaved duplex siRNA",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 110,
      "y" : 692
    },
    "minX" : 14,
    "maxX" : 212,
    "minY" : 675,
    "maxY" : 703,
    "prop" : {
      "x" : 14,
      "y" : 681,
      "width" : 192,
      "height" : 22
    },
    "textPosition" : {
      "x" : 21,
      "y" : 682
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 206,
          "y" : 681
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 206,
          "y" : 681
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 50816,
      "type" : "INPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 50813,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  } ],
  "edges" : [ {
    "id" : 50816,
    "reactomeId" : 10086947,
    "displayName" : "C3PO hydrolyzes cleaved passenger strand",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 110,
      "y" : 768
    },
    "minX" : 104,
    "maxX" : 116,
    "minY" : 706,
    "maxY" : 852,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 110,
        "y" : 706
      },
      "to" : {
        "x" : 110,
        "y" : 768
      }
    }, {
      "from" : {
        "x" : 110,
        "y" : 768
      },
      "to" : {
        "x" : 111,
        "y" : 852
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 107,
        "y" : 845
      },
      "b" : {
        "x" : 111,
        "y" : 852
      },
      "c" : {
        "x" : 115,
        "y" : 845
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 115,
        "y" : 845
      }
    },
    "reactionShape" : {
      "a" : {
        "x" : 104,
        "y" : 762
      },
      "b" : {
        "x" : 116,
        "y" : 774
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 110,
        "y" : 768
      }
    },
    "inputs" : [ {
      "id" : 50815
    } ],
    "outputs" : [ {
      "id" : 50817
    } ],
    "catalysts" : [ {
      "id" : 50818,
      "points" : [ {
        "x" : 86,
        "y" : 767
      } ]
    } ]
  }, {
    "id" : 50786,
    "reactomeId" : 10015587,
    "displayName" : "RISC binds inexactly matching target RNAs",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 808,
      "y" : 1146
    },
    "minX" : 802,
    "maxX" : 814,
    "minY" : 1079,
    "maxY" : 1194,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 807,
        "y" : 1079
      },
      "to" : {
        "x" : 808,
        "y" : 1146
      }
    }, {
      "from" : {
        "x" : 808,
        "y" : 1146
      },
      "to" : {
        "x" : 808,
        "y" : 1194
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 804,
        "y" : 1187
      },
      "b" : {
        "x" : 808,
        "y" : 1194
      },
      "c" : {
        "x" : 812,
        "y" : 1187
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 812,
        "y" : 1187
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 808,
        "y" : 1146
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 808,
        "y" : 1146
      }
    },
    "inputs" : [ {
      "id" : 50787,
      "points" : [ {
        "x" : 689,
        "y" : 1037
      } ]
    }, {
      "id" : 50788,
      "points" : [ {
        "x" : 531,
        "y" : 925
      }, {
        "x" : 796,
        "y" : 943
      } ]
    }, {
      "id" : 50789,
      "points" : [ {
        "x" : 864,
        "y" : 1051
      } ]
    } ],
    "outputs" : [ {
      "id" : 50790
    } ]
  }, {
    "id" : 50791,
    "reactomeId" : 10015594,
    "displayName" : "Nonendonucleolytic RISC binds exactly matching target RNAs",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 526,
      "y" : 1139
    },
    "minX" : 520,
    "maxX" : 532,
    "minY" : 1090,
    "maxY" : 1192,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 525,
        "y" : 1090
      },
      "to" : {
        "x" : 526,
        "y" : 1139
      }
    }, {
      "from" : {
        "x" : 526,
        "y" : 1139
      },
      "to" : {
        "x" : 526,
        "y" : 1192
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 522,
        "y" : 1185
      },
      "b" : {
        "x" : 526,
        "y" : 1192
      },
      "c" : {
        "x" : 530,
        "y" : 1185
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 530,
        "y" : 1185
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 526,
        "y" : 1139
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 526,
        "y" : 1139
      }
    },
    "inputs" : [ {
      "id" : 50792,
      "points" : [ {
        "x" : 479,
        "y" : 1007
      } ]
    }, {
      "id" : 50787,
      "points" : [ {
        "x" : 622,
        "y" : 1037
      } ]
    }, {
      "id" : 50783,
      "points" : [ {
        "x" : 381,
        "y" : 1056
      } ]
    } ],
    "outputs" : [ {
      "id" : 50793
    } ]
  }, {
    "id" : 50794,
    "reactomeId" : 10041870,
    "displayName" : "Duplex miRNA is loaded into Argonaute",
    "schemaClass" : "BlackBoxEvent",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 633,
      "y" : 695
    },
    "minX" : 627,
    "maxX" : 639,
    "minY" : 664,
    "maxY" : 724,
    "reactionType" : "omitted",
    "segments" : [ {
      "from" : {
        "x" : 631,
        "y" : 664
      },
      "to" : {
        "x" : 633,
        "y" : 695
      }
    }, {
      "from" : {
        "x" : 633,
        "y" : 695
      },
      "to" : {
        "x" : 634,
        "y" : 724
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 630,
        "y" : 717
      },
      "b" : {
        "x" : 634,
        "y" : 724
      },
      "c" : {
        "x" : 638,
        "y" : 717
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 638,
        "y" : 717
      }
    },
    "reactionShape" : {
      "a" : {
        "x" : 627,
        "y" : 689
      },
      "b" : {
        "x" : 639,
        "y" : 701
      },
      "s" : "\\\\",
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 633,
        "y" : 695
      }
    },
    "inputs" : [ {
      "id" : 50795
    } ],
    "outputs" : [ {
      "id" : 50776
    } ]
  }, {
    "id" : 50796,
    "reactomeId" : 10041898,
    "displayName" : "Duplex siRNA is loaded into Argonaute",
    "schemaClass" : "BlackBoxEvent",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 243,
      "y" : 700
    },
    "minX" : 237,
    "maxX" : 249,
    "minY" : 669,
    "maxY" : 727,
    "reactionType" : "omitted",
    "segments" : [ {
      "from" : {
        "x" : 243,
        "y" : 669
      },
      "to" : {
        "x" : 243,
        "y" : 700
      }
    }, {
      "from" : {
        "x" : 243,
        "y" : 700
      },
      "to" : {
        "x" : 244,
        "y" : 727
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 240,
        "y" : 720
      },
      "b" : {
        "x" : 244,
        "y" : 727
      },
      "c" : {
        "x" : 248,
        "y" : 720
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 248,
        "y" : 720
      }
    },
    "reactionShape" : {
      "a" : {
        "x" : 237,
        "y" : 694
      },
      "b" : {
        "x" : 249,
        "y" : 706
      },
      "s" : "\\\\",
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 243,
        "y" : 700
      }
    },
    "inputs" : [ {
      "id" : 50781
    } ],
    "outputs" : [ {
      "id" : 50797
    } ]
  }, {
    "id" : 50798,
    "reactomeId" : 10041896,
    "displayName" : "Removal of siRNA passenger strand",
    "schemaClass" : "BlackBoxEvent",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 245,
      "y" : 813
    },
    "minX" : 239,
    "maxX" : 251,
    "minY" : 789,
    "maxY" : 841,
    "reactionType" : "omitted",
    "segments" : [ {
      "from" : {
        "x" : 245,
        "y" : 789
      },
      "to" : {
        "x" : 245,
        "y" : 813
      }
    }, {
      "from" : {
        "x" : 245,
        "y" : 813
      },
      "to" : {
        "x" : 245,
        "y" : 841
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 241,
        "y" : 834
      },
      "b" : {
        "x" : 245,
        "y" : 841
      },
      "c" : {
        "x" : 249,
        "y" : 834
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 249,
        "y" : 834
      }
    },
    "reactionShape" : {
      "a" : {
        "x" : 239,
        "y" : 807
      },
      "b" : {
        "x" : 251,
        "y" : 819
      },
      "s" : "\\\\",
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 245,
        "y" : 813
      }
    },
    "inputs" : [ {
      "id" : 50797
    } ],
    "outputs" : [ {
      "id" : 50799
    } ]
  }, {
    "id" : 50800,
    "reactomeId" : 10055211,
    "displayName" : "Importin-8 binds AGO2:miRNA",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 837,
      "y" : 602
    },
    "minX" : 831,
    "maxX" : 843,
    "minY" : 481,
    "maxY" : 718,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 837,
        "y" : 718
      },
      "to" : {
        "x" : 837,
        "y" : 602
      }
    }, {
      "from" : {
        "x" : 837,
        "y" : 602
      },
      "to" : {
        "x" : 838,
        "y" : 481
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 842,
        "y" : 488
      },
      "b" : {
        "x" : 838,
        "y" : 481
      },
      "c" : {
        "x" : 834,
        "y" : 488
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 834,
        "y" : 488
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 837,
        "y" : 602
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 837,
        "y" : 602
      }
    },
    "inputs" : [ {
      "id" : 50801,
      "points" : [ {
        "x" : 821,
        "y" : 867
      } ]
    }, {
      "id" : 50802,
      "points" : [ {
        "x" : 882,
        "y" : 769
      } ]
    } ],
    "outputs" : [ {
      "id" : 50803
    } ]
  }, {
    "id" : 50804,
    "reactomeId" : 10055225,
    "displayName" : "Importin-8 imports AGO2:miRNA into the nucleus",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 837,
      "y" : 339
    },
    "minX" : 831,
    "maxX" : 843,
    "minY" : 307,
    "maxY" : 365,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 836,
        "y" : 365
      },
      "to" : {
        "x" : 837,
        "y" : 339
      }
    }, {
      "from" : {
        "x" : 837,
        "y" : 339
      },
      "to" : {
        "x" : 834,
        "y" : 307
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 831,
        "y" : 333
      },
      "b" : {
        "x" : 843,
        "y" : 345
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 837,
        "y" : 339
      }
    },
    "inputs" : [ {
      "id" : 50803,
      "points" : [ {
        "x" : 838,
        "y" : 451
      } ]
    }, {
      "id" : 50805,
      "points" : [ {
        "x" : 790,
        "y" : 377
      } ]
    } ],
    "outputs" : [ {
      "id" : 50806,
      "points" : [ {
        "x" : 860,
        "y" : 287
      } ]
    }, {
      "id" : 50807,
      "points" : [ {
        "x" : 760,
        "y" : 272
      } ]
    } ]
  }, {
    "id" : 50775,
    "reactomeId" : 10006631,
    "displayName" : "Removal of miRNA passenger strand",
    "schemaClass" : "BlackBoxEvent",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 638,
      "y" : 814
    },
    "minX" : 632,
    "maxX" : 644,
    "minY" : 789,
    "maxY" : 842,
    "reactionType" : "omitted",
    "segments" : [ {
      "from" : {
        "x" : 636,
        "y" : 789
      },
      "to" : {
        "x" : 638,
        "y" : 814
      }
    }, {
      "from" : {
        "x" : 638,
        "y" : 814
      },
      "to" : {
        "x" : 638,
        "y" : 842
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 634,
        "y" : 835
      },
      "b" : {
        "x" : 638,
        "y" : 842
      },
      "c" : {
        "x" : 642,
        "y" : 835
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 642,
        "y" : 835
      }
    },
    "reactionShape" : {
      "a" : {
        "x" : 632,
        "y" : 808
      },
      "b" : {
        "x" : 644,
        "y" : 820
      },
      "s" : "\\\\",
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 638,
        "y" : 814
      }
    },
    "inputs" : [ {
      "id" : 50776
    } ],
    "outputs" : [ {
      "id" : 50777
    } ]
  }, {
    "id" : 50808,
    "reactomeId" : 10055292,
    "displayName" : "TNRC6A binds AGO2:miRNA",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 1021,
      "y" : 784
    },
    "minX" : 1015,
    "maxX" : 1027,
    "minY" : 715,
    "maxY" : 852,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 1022,
        "y" : 852
      },
      "to" : {
        "x" : 1021,
        "y" : 784
      }
    }, {
      "from" : {
        "x" : 1021,
        "y" : 784
      },
      "to" : {
        "x" : 1021,
        "y" : 715
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 1025,
        "y" : 722
      },
      "b" : {
        "x" : 1021,
        "y" : 715
      },
      "c" : {
        "x" : 1017,
        "y" : 722
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 1017,
        "y" : 722
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 1021,
        "y" : 784
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 1021,
        "y" : 784
      }
    },
    "inputs" : [ {
      "id" : 50809,
      "points" : [ {
        "x" : 1022,
        "y" : 940
      } ]
    }, {
      "id" : 50801,
      "points" : [ {
        "x" : 853,
        "y" : 882
      } ]
    } ],
    "outputs" : [ {
      "id" : 50810
    } ]
  }, {
    "id" : 50778,
    "reactomeId" : 10015558,
    "displayName" : "Dicer cleaves double-stranded RNA to yield double-stranded siRNA",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 239,
      "y" : 577
    },
    "minX" : 221,
    "maxX" : 245,
    "minY" : 562,
    "maxY" : 617,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 221,
        "y" : 562
      },
      "to" : {
        "x" : 239,
        "y" : 577
      }
    }, {
      "from" : {
        "x" : 239,
        "y" : 577
      },
      "to" : {
        "x" : 241,
        "y" : 617
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 237,
        "y" : 610
      },
      "b" : {
        "x" : 241,
        "y" : 617
      },
      "c" : {
        "x" : 245,
        "y" : 610
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 245,
        "y" : 610
      }
    },
    "reactionShape" : {
      "a" : {
        "x" : 233,
        "y" : 571
      },
      "b" : {
        "x" : 245,
        "y" : 583
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 239,
        "y" : 577
      }
    },
    "inputs" : [ {
      "id" : 50779,
      "points" : [ {
        "x" : 172,
        "y" : 553
      } ]
    }, {
      "id" : 50780,
      "points" : [ {
        "x" : 331,
        "y" : 550
      } ]
    } ],
    "outputs" : [ {
      "id" : 50781
    } ],
    "catalysts" : [ {
      "id" : 50780,
      "points" : [ {
        "x" : 331,
        "y" : 557
      } ]
    } ]
  }, {
    "id" : 50811,
    "reactomeId" : 10055298,
    "displayName" : "TNRC6A:AGO2:miRNA is transported into the nucleus",
    "schemaClass" : "BlackBoxEvent",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 1018,
      "y" : 336
    },
    "minX" : 1012,
    "maxX" : 1024,
    "minY" : 298,
    "maxY" : 681,
    "reactionType" : "omitted",
    "segments" : [ {
      "from" : {
        "x" : 1020,
        "y" : 681
      },
      "to" : {
        "x" : 1018,
        "y" : 336
      }
    }, {
      "from" : {
        "x" : 1018,
        "y" : 336
      },
      "to" : {
        "x" : 1021,
        "y" : 298
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 1024,
        "y" : 305
      },
      "b" : {
        "x" : 1021,
        "y" : 298
      },
      "c" : {
        "x" : 1016,
        "y" : 305
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 1016,
        "y" : 305
      }
    },
    "reactionShape" : {
      "a" : {
        "x" : 1012,
        "y" : 330
      },
      "b" : {
        "x" : 1024,
        "y" : 342
      },
      "s" : "\\\\",
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 1018,
        "y" : 336
      }
    },
    "inputs" : [ {
      "id" : 50810
    } ],
    "outputs" : [ {
      "id" : 50812
    } ]
  }, {
    "id" : 50813,
    "reactomeId" : 10086950,
    "displayName" : "AGO2 cleaves passenger strand of duplex siRNA",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 108,
      "y" : 636
    },
    "minX" : 102,
    "maxX" : 114,
    "minY" : 595,
    "maxY" : 678,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 102,
        "y" : 595
      },
      "to" : {
        "x" : 108,
        "y" : 636
      }
    }, {
      "from" : {
        "x" : 108,
        "y" : 636
      },
      "to" : {
        "x" : 109,
        "y" : 678
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 105,
        "y" : 671
      },
      "b" : {
        "x" : 109,
        "y" : 678
      },
      "c" : {
        "x" : 113,
        "y" : 671
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 113,
        "y" : 671
      }
    },
    "reactionShape" : {
      "a" : {
        "x" : 102,
        "y" : 630
      },
      "b" : {
        "x" : 114,
        "y" : 642
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 108,
        "y" : 636
      }
    },
    "inputs" : [ {
      "id" : 50814
    } ],
    "outputs" : [ {
      "id" : 50815
    } ],
    "catalysts" : [ {
      "id" : 50814,
      "points" : [ {
        "x" : 109,
        "y" : 595
      } ]
    } ]
  }, {
    "id" : 50782,
    "reactomeId" : 10015590,
    "displayName" : "Endonucleolytic RISC hydrolyzes target RNAs",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 191,
      "y" : 1083
    },
    "minX" : 185,
    "maxX" : 277,
    "minY" : 1056,
    "maxY" : 1197,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 277,
        "y" : 1056
      },
      "to" : {
        "x" : 191,
        "y" : 1083
      }
    }, {
      "from" : {
        "x" : 191,
        "y" : 1083
      },
      "to" : {
        "x" : 191,
        "y" : 1197
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 187,
        "y" : 1190
      },
      "b" : {
        "x" : 191,
        "y" : 1197
      },
      "c" : {
        "x" : 195,
        "y" : 1190
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 195,
        "y" : 1190
      }
    },
    "reactionShape" : {
      "a" : {
        "x" : 185,
        "y" : 1077
      },
      "b" : {
        "x" : 197,
        "y" : 1089
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 191,
        "y" : 1083
      }
    },
    "inputs" : [ {
      "id" : 50783
    } ],
    "outputs" : [ {
      "id" : 50784,
      "stoichiometry" : 2
    } ],
    "catalysts" : [ {
      "id" : 50785,
      "points" : [ {
        "x" : 188,
        "y" : 1006
      } ]
    } ]
  } ],
  "compartments" : [ {
    "id" : 50819,
    "reactomeId" : 7660,
    "displayName" : "nucleoplasm",
    "schemaClass" : "Compartment",
    "renderableClass" : "Compartment",
    "position" : {
      "x" : 861,
      "y" : 180
    },
    "minX" : 25,
    "maxX" : 1697,
    "minY" : 16,
    "maxY" : 345,
    "prop" : {
      "x" : 25,
      "y" : 16,
      "width" : 1672,
      "height" : 329
    },
    "textPosition" : {
      "x" : 40,
      "y" : 285
    },
    "insets" : {
      "x" : 35,
      "y" : 26,
      "width" : 1652,
      "height" : 309
    },
    "bgColor" : {
      "r" : 250,
      "g" : 240,
      "b" : 240
    },
    "componentIds" : [ 50804, 50807, 50812, 50811, 50806, 50839 ]
  }, {
    "id" : 50823,
    "reactomeId" : 70101,
    "displayName" : "cytosol",
    "schemaClass" : "Compartment",
    "renderableClass" : "Compartment",
    "position" : {
      "x" : 1048,
      "y" : 639
    },
    "minX" : 0,
    "maxX" : 2096,
    "minY" : 0,
    "maxY" : 1278,
    "prop" : {
      "x" : 0,
      "y" : 0,
      "width" : 2096,
      "height" : 1278
    },
    "textPosition" : {
      "x" : 17,
      "y" : 1223
    },
    "insets" : {
      "x" : 10,
      "y" : 10,
      "width" : 2076,
      "height" : 1258
    },
    "bgColor" : {
      "r" : 250,
      "g" : 240,
      "b" : 240
    },
    "componentIds" : [ 50775, 50792, 50782, 50783, 50784, 50786, 50788, 50789, 50790, 50791, 50793, 50819, 50785, 50778, 50779, 50814, 50817, 50794, 50796, 50798, 50787, 50801, 50800, 50802, 50803, 50838, 50808, 50809, 50810, 50818, 50805, 50840, 50841, 50780, 50795, 50776, 50777, 50797, 50799, 50781, 50813, 50815, 50816, 50842 ]
  } ],
  "notes" : [ ],
  "links" : [ {
    "id" : 50838,
    "renderableClass" : "EntitySetAndMemberLink",
    "position" : {
      "x" : 854,
      "y" : 981
    },
    "minX" : 726,
    "maxX" : 982,
    "minY" : 960,
    "maxY" : 1002,
    "segments" : [ {
      "from" : {
        "x" : 982,
        "y" : 960
      },
      "to" : {
        "x" : 726,
        "y" : 1002
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 848,
        "y" : 975
      },
      "b" : {
        "x" : 860,
        "y" : 987
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 854,
        "y" : 981
      }
    },
    "inputs" : [ {
      "id" : 50809
    } ],
    "outputs" : [ {
      "id" : 50787
    } ]
  }, {
    "id" : 50840,
    "renderableClass" : "EntitySetAndMemberLink",
    "position" : {
      "x" : 329,
      "y" : 953
    },
    "minX" : 252,
    "maxX" : 407,
    "minY" : 940,
    "maxY" : 967,
    "segments" : [ {
      "from" : {
        "x" : 252,
        "y" : 967
      },
      "to" : {
        "x" : 407,
        "y" : 940
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 323,
        "y" : 947
      },
      "b" : {
        "x" : 335,
        "y" : 959
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 329,
        "y" : 953
      }
    },
    "inputs" : [ {
      "id" : 50785
    } ],
    "outputs" : [ {
      "id" : 50788
    } ]
  }, {
    "id" : 50841,
    "renderableClass" : "EntitySetAndMemberLink",
    "position" : {
      "x" : 467,
      "y" : 954
    },
    "minX" : 461,
    "maxX" : 473,
    "minY" : 940,
    "maxY" : 969,
    "segments" : [ {
      "from" : {
        "x" : 470,
        "y" : 969
      },
      "to" : {
        "x" : 465,
        "y" : 940
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 461,
        "y" : 948
      },
      "b" : {
        "x" : 473,
        "y" : 960
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 467,
        "y" : 954
      }
    },
    "inputs" : [ {
      "id" : 50792
    } ],
    "outputs" : [ {
      "id" : 50788
    } ]
  } ],
  "shadows" : [ {
    "id" : 50842,
    "reactomeId" : 10099885,
    "displayName" : "MicroRNA (miRNA) biogenesis",
    "schemaClass" : "Pathway",
    "renderableClass" : "Shadow",
    "position" : {
      "x" : 631,
      "y" : 758
    },
    "minX" : 555,
    "maxX" : 708,
    "minY" : 607,
    "maxY" : 910,
    "prop" : {
      "x" : 555,
      "y" : 607,
      "width" : 153,
      "height" : 303
    },
    "points" : [ {
      "x" : 555,
      "y" : 607
    }, {
      "x" : 708,
      "y" : 607
    }, {
      "x" : 708,
      "y" : 910
    }, {
      "x" : 555,
      "y" : 910
    } ],
    "colour" : "#4684ee"
  }, {
    "id" : 50843,
    "reactomeId" : 10100257,
    "displayName" : "Small interfering RNA (siRNA) biogenesis",
    "schemaClass" : "Pathway",
    "renderableClass" : "Shadow",
    "position" : {
      "x" : 246,
      "y" : 711
    },
    "minX" : 4,
    "maxX" : 488,
    "minY" : 518,
    "maxY" : 904,
    "prop" : {
      "x" : 4,
      "y" : 518,
      "width" : 484,
      "height" : 382
    },
    "points" : [ {
      "x" : 4,
      "y" : 518
    }, {
      "x" : 488,
      "y" : 518
    }, {
      "x" : 488,
      "y" : 904
    }, {
      "x" : 4,
      "y" : 904
    } ],
    "colour" : "#dc3912"
  }, {
    "id" : 50844,
    "reactomeId" : 10100259,
    "displayName" : "Post-transcriptional silencing by small RNAs",
    "schemaClass" : "Pathway",
    "renderableClass" : "Shadow",
    "position" : {
      "x" : 497,
      "y" : 1071
    },
    "minX" : 23,
    "maxX" : 971,
    "minY" : 900,
    "maxY" : 1243,
    "prop" : {
      "x" : 23,
      "y" : 975,
      "width" : 948,
      "height" : 268
    },
    "points" : [ {
      "x" : 23,
      "y" : 900
    }, {
      "x" : 971,
      "y" : 900
    }, {
      "x" : 971,
      "y" : 1243
    }, {
      "x" : 23,
      "y" : 1243
    } ],
    "colour" : "#008000"
  }, {
    "id" : 50845,
    "reactomeId" : 10101151,
    "displayName" : "Transcriptional regulation by small RNAs",
    "schemaClass" : "Pathway",
    "renderableClass" : "Shadow",
    "position" : {
      "x" : 890,
      "y" : 604
    },
    "minX" : 669,
    "maxX" : 1112,
    "minY" : 234,
    "maxY" : 975,
    "prop" : {
      "x" : 669,
      "y" : 234,
      "width" : 443,
      "height" : 373
    },
    "points" : [ {
      "x" : 669,
      "y" : 234
    }, {
      "x" : 1112,
      "y" : 234
    }, {
      "x" : 1112,
      "y" : 975
    }, {
      "x" : 669,
      "y" : 975
    } ],
    "colour" : "#666666"
  } ],
  "minX" : 0,
  "maxX" : 2096,
  "minY" : 0,
  "maxY" : 1278,
  "disease" : false
}