{
  "dbId" : 10099509,
  "stableId" : "R-MMU-5654736",
  "displayName" : "Signaling by FGFR1",
  "nodes" : [ {
    "id" : 38448,
    "reactomeId" : 10000593,
    "displayName" : "FGFR1b",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 379,
      "y" : 410
    },
    "minX" : 321,
    "maxX" : 444,
    "minY" : 385,
    "maxY" : 581,
    "prop" : {
      "x" : 321,
      "y" : 391,
      "width" : 117,
      "height" : 38
    },
    "textPosition" : {
      "x" : 352,
      "y" : 399
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 438,
          "y" : 391
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 438,
          "y" : 391
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 38447,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 381,
          "y" : 432
        },
        "to" : {
          "x" : 403,
          "y" : 581
        }
      } ],
      "stoichiometry" : {
        "value" : 2,
        "shape" : {
          "a" : {
            "x" : 386,
            "y" : 500
          },
          "b" : {
            "x" : 398,
            "y" : 512
          },
          "type" : "BOX",
          "empty" : true,
          "centre" : {
            "x" : 392,
            "y" : 506
          }
        }
      }
    } ]
  }, {
    "id" : 38449,
    "reactomeId" : 9991322,
    "displayName" : "FGFR1b-binding FGFs",
    "schemaClass" : "DefinedSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 47,
      "y" : 512
    },
    "minX" : 0,
    "maxX" : 403,
    "minY" : 497,
    "maxY" : 581,
    "prop" : {
      "x" : 0,
      "y" : 497,
      "width" : 94,
      "height" : 31
    },
    "textPosition" : {
      "x" : 3,
      "y" : 495
    },
    "connectors" : [ {
      "edgeId" : 38447,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 100,
          "y" : 521
        },
        "to" : {
          "x" : 403,
          "y" : 581
        }
      } ],
      "stoichiometry" : {
        "value" : 2,
        "shape" : {
          "a" : {
            "x" : 245,
            "y" : 545
          },
          "b" : {
            "x" : 257,
            "y" : 557
          },
          "type" : "BOX",
          "empty" : true,
          "centre" : {
            "x" : 251,
            "y" : 551
          }
        }
      }
    } ]
  }, {
    "id" : 38450,
    "reactomeId" : 190915,
    "displayName" : "HS",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 55,
      "y" : 587
    },
    "minX" : 5,
    "maxX" : 403,
    "minY" : 568,
    "maxY" : 648,
    "prop" : {
      "x" : 5,
      "y" : 569,
      "width" : 101,
      "height" : 36
    },
    "textPosition" : {
      "x" : 43,
      "y" : 576
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 101,
          "y" : 574
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 101,
          "y" : 574
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 38447,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 109,
          "y" : 586
        },
        "to" : {
          "x" : 403,
          "y" : 581
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 38447,
      "type" : "ACTIVATOR",
      "segments" : [ {
        "from" : {
          "x" : 109,
          "y" : 598
        },
        "to" : {
          "x" : 314,
          "y" : 648
        }
      }, {
        "from" : {
          "x" : 314,
          "y" : 648
        },
        "to" : {
          "x" : 395,
          "y" : 604
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 391,
          "y" : 611
        },
        "b" : {
          "x" : 395,
          "y" : 604
        },
        "c" : {
          "x" : 387,
          "y" : 604
        },
        "type" : "ARROW",
        "empty" : true,
        "centre" : {
          "x" : 387,
          "y" : 604
        }
      }
    } ]
  }, {
    "id" : 38451,
    "reactomeId" : 10000597,
    "displayName" : "FGFR1b homodimer bound to FGF",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 410,
      "y" : 667
    },
    "minX" : 345,
    "maxX" : 464,
    "minY" : 634,
    "maxY" : 754,
    "prop" : {
      "x" : 363,
      "y" : 640,
      "width" : 95,
      "height" : 54
    },
    "textPosition" : {
      "x" : 364,
      "y" : 645
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 458,
          "y" : 640
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 458,
          "y" : 640
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 38447,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 38453,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 410,
          "y" : 697
        },
        "to" : {
          "x" : 410,
          "y" : 727
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 38453,
      "type" : "CATALYST",
      "segments" : [ {
        "from" : {
          "x" : 385,
          "y" : 697
        },
        "to" : {
          "x" : 345,
          "y" : 739
        }
      }, {
        "from" : {
          "x" : 345,
          "y" : 739
        },
        "to" : {
          "x" : 391,
          "y" : 749
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 395,
          "y" : 750
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 395,
          "y" : 750
        }
      }
    } ]
  }, {
    "id" : 38452,
    "reactomeId" : 10000605,
    "displayName" : "FGF2:TGFBR3:GIPC1",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 726,
      "y" : 476
    },
    "minX" : 290,
    "maxX" : 796,
    "minY" : 459,
    "maxY" : 1092,
    "prop" : {
      "x" : 663,
      "y" : 465,
      "width" : 127,
      "height" : 23
    },
    "textPosition" : {
      "x" : 679,
      "y" : 453
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 790,
          "y" : 465
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 790,
          "y" : 465
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 38447,
      "type" : "ACTIVATOR",
      "segments" : [ {
        "from" : {
          "x" : 696,
          "y" : 491
        },
        "to" : {
          "x" : 411,
          "y" : 597
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 416,
          "y" : 591
        },
        "b" : {
          "x" : 411,
          "y" : 597
        },
        "c" : {
          "x" : 419,
          "y" : 598
        },
        "type" : "ARROW",
        "empty" : true,
        "centre" : {
          "x" : 419,
          "y" : 598
        }
      }
    }, {
      "edgeId" : 38457,
      "type" : "ACTIVATOR",
      "segments" : [ {
        "from" : {
          "x" : 717,
          "y" : 491
        },
        "to" : {
          "x" : 290,
          "y" : 1092
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 291,
          "y" : 1084
        },
        "b" : {
          "x" : 290,
          "y" : 1092
        },
        "c" : {
          "x" : 297,
          "y" : 1089
        },
        "type" : "ARROW",
        "empty" : true,
        "centre" : {
          "x" : 297,
          "y" : 1089
        }
      }
    } ]
  }, {
    "id" : 38454,
    "reactomeId" : 113592,
    "displayName" : "ATP",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 496,
      "y" : 712
    },
    "minX" : 410,
    "maxX" : 517,
    "minY" : 696,
    "maxY" : 727,
    "prop" : {
      "x" : 476,
      "y" : 697,
      "width" : 40,
      "height" : 30
    },
    "textPosition" : {
      "x" : 480,
      "y" : 701
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 511,
          "y" : 702
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 511,
          "y" : 702
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 38453,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 473,
          "y" : 715
        },
        "to" : {
          "x" : 410,
          "y" : 727
        }
      } ],
      "stoichiometry" : {
        "value" : 16,
        "shape" : {
          "a" : {
            "x" : 435,
            "y" : 715
          },
          "b" : {
            "x" : 447,
            "y" : 727
          },
          "type" : "BOX",
          "empty" : true,
          "centre" : {
            "x" : 441,
            "y" : 721
          }
        }
      }
    } ]
  }, {
    "id" : 38455,
    "reactomeId" : 9991337,
    "displayName" : "Activated FGFR1b homodimer",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 420,
      "y" : 832
    },
    "minX" : 361,
    "maxX" : 486,
    "minY" : 775,
    "maxY" : 853,
    "prop" : {
      "x" : 361,
      "y" : 812,
      "width" : 119,
      "height" : 41
    },
    "textPosition" : {
      "x" : 360,
      "y" : 818
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 480,
          "y" : 812
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 480,
          "y" : 812
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 38453,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 414,
          "y" : 809
        },
        "to" : {
          "x" : 406,
          "y" : 775
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 409,
          "y" : 803
        },
        "b" : {
          "x" : 414,
          "y" : 809
        },
        "c" : {
          "x" : 416,
          "y" : 801
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 416,
          "y" : 801
        }
      }
    } ]
  }, {
    "id" : 38456,
    "reactomeId" : 29370,
    "displayName" : "ADP",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 484,
      "y" : 792
    },
    "minX" : 406,
    "maxX" : 506,
    "minY" : 775,
    "maxY" : 807,
    "prop" : {
      "x" : 463,
      "y" : 777,
      "width" : 42,
      "height" : 30
    },
    "textPosition" : {
      "x" : 467,
      "y" : 781
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 500,
          "y" : 782
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 500,
          "y" : 782
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 38453,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 460,
          "y" : 787
        },
        "to" : {
          "x" : 406,
          "y" : 775
        }
      } ],
      "stoichiometry" : {
        "value" : 16,
        "shape" : {
          "a" : {
            "x" : 427,
            "y" : 775
          },
          "b" : {
            "x" : 439,
            "y" : 787
          },
          "type" : "BOX",
          "empty" : true,
          "centre" : {
            "x" : 433,
            "y" : 781
          }
        }
      },
      "endShape" : {
        "a" : {
          "x" : 452,
          "y" : 789
        },
        "b" : {
          "x" : 460,
          "y" : 787
        },
        "c" : {
          "x" : 454,
          "y" : 782
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 454,
          "y" : 782
        }
      }
    } ]
  }, {
    "id" : 38458,
    "reactomeId" : 9991366,
    "displayName" : "FGFR1c-binding FGFs",
    "schemaClass" : "DefinedSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 87,
      "y" : 943
    },
    "minX" : 33,
    "maxX" : 283,
    "minY" : 925,
    "maxY" : 1067,
    "prop" : {
      "x" : 33,
      "y" : 925,
      "width" : 109,
      "height" : 36
    },
    "textPosition" : {
      "x" : 33,
      "y" : 925
    },
    "connectors" : [ {
      "edgeId" : 38457,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 115,
          "y" : 967
        },
        "to" : {
          "x" : 283,
          "y" : 1067
        }
      } ],
      "stoichiometry" : {
        "value" : 2,
        "shape" : {
          "a" : {
            "x" : 193,
            "y" : 1011
          },
          "b" : {
            "x" : 205,
            "y" : 1023
          },
          "type" : "BOX",
          "empty" : true,
          "centre" : {
            "x" : 199,
            "y" : 1017
          }
        }
      }
    } ]
  }, {
    "id" : 38459,
    "reactomeId" : 420339,
    "displayName" : "Basic fibroblast growth factor receptor 1",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 257,
      "y" : 879
    },
    "minX" : 196,
    "maxX" : 432,
    "minY" : 854,
    "maxY" : 1587,
    "prop" : {
      "x" : 196,
      "y" : 860,
      "width" : 122,
      "height" : 39
    },
    "textPosition" : {
      "x" : 203,
      "y" : 855
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 318,
          "y" : 860
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 318,
          "y" : 860
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 38466,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 266,
          "y" : 902
        },
        "to" : {
          "x" : 428,
          "y" : 1246
        }
      }, {
        "from" : {
          "x" : 428,
          "y" : 1246
        },
        "to" : {
          "x" : 432,
          "y" : 1502
        }
      }, {
        "from" : {
          "x" : 432,
          "y" : 1502
        },
        "to" : {
          "x" : 282,
          "y" : 1587
        }
      } ],
      "stoichiometry" : {
        "value" : 2,
        "shape" : {
          "a" : {
            "x" : 341,
            "y" : 1068
          },
          "b" : {
            "x" : 353,
            "y" : 1080
          },
          "type" : "BOX",
          "empty" : true,
          "centre" : {
            "x" : 347,
            "y" : 1074
          }
        }
      }
    }, {
      "edgeId" : 38457,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 259,
          "y" : 902
        },
        "to" : {
          "x" : 283,
          "y" : 1067
        }
      } ],
      "stoichiometry" : {
        "value" : 2,
        "shape" : {
          "a" : {
            "x" : 265,
            "y" : 978
          },
          "b" : {
            "x" : 277,
            "y" : 990
          },
          "type" : "BOX",
          "empty" : true,
          "centre" : {
            "x" : 271,
            "y" : 984
          }
        }
      }
    } ]
  }, {
    "id" : 38460,
    "reactomeId" : 190915,
    "displayName" : "HS",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 120,
      "y" : 1051
    },
    "minX" : 64,
    "maxX" : 283,
    "minY" : 1032,
    "maxY" : 1098,
    "prop" : {
      "x" : 64,
      "y" : 1033,
      "width" : 113,
      "height" : 36
    },
    "textPosition" : {
      "x" : 108,
      "y" : 1040
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 172,
          "y" : 1038
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 172,
          "y" : 1038
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 38457,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 180,
          "y" : 1056
        },
        "to" : {
          "x" : 283,
          "y" : 1067
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 38457,
      "type" : "ACTIVATOR",
      "segments" : [ {
        "from" : {
          "x" : 180,
          "y" : 1066
        },
        "to" : {
          "x" : 219,
          "y" : 1079
        }
      }, {
        "from" : {
          "x" : 219,
          "y" : 1079
        },
        "to" : {
          "x" : 276,
          "y" : 1096
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 268,
          "y" : 1098
        },
        "b" : {
          "x" : 276,
          "y" : 1096
        },
        "c" : {
          "x" : 271,
          "y" : 1090
        },
        "type" : "ARROW",
        "empty" : true,
        "centre" : {
          "x" : 271,
          "y" : 1090
        }
      }
    } ]
  }, {
    "id" : 38461,
    "reactomeId" : 10000610,
    "displayName" : "FGFR1c homodimer bound to FGF",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 283,
      "y" : 1279
    },
    "minX" : 217,
    "maxX" : 356,
    "minY" : 1255,
    "maxY" : 1340,
    "prop" : {
      "x" : 217,
      "y" : 1261,
      "width" : 133,
      "height" : 36
    },
    "textPosition" : {
      "x" : 217,
      "y" : 1262
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 350,
          "y" : 1261
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 350,
          "y" : 1261
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 38457,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 38462,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 282,
          "y" : 1300
        },
        "to" : {
          "x" : 281,
          "y" : 1323
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 38462,
      "type" : "CATALYST",
      "segments" : [ {
        "from" : {
          "x" : 256,
          "y" : 1300
        },
        "to" : {
          "x" : 225,
          "y" : 1319
        }
      }, {
        "from" : {
          "x" : 225,
          "y" : 1319
        },
        "to" : {
          "x" : 267,
          "y" : 1334
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 271,
          "y" : 1336
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 271,
          "y" : 1336
        }
      }
    } ]
  }, {
    "id" : 38463,
    "reactomeId" : 113592,
    "displayName" : "ATP",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 359,
      "y" : 1319
    },
    "minX" : 281,
    "maxX" : 390,
    "minY" : 1305,
    "maxY" : 1332,
    "prop" : {
      "x" : 329,
      "y" : 1306,
      "width" : 60,
      "height" : 26
    },
    "textPosition" : {
      "x" : 343,
      "y" : 1308
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 384,
          "y" : 1311
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 384,
          "y" : 1311
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 38462,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 326,
          "y" : 1320
        },
        "to" : {
          "x" : 281,
          "y" : 1323
        }
      } ],
      "stoichiometry" : {
        "value" : 16,
        "shape" : {
          "a" : {
            "x" : 297,
            "y" : 1315
          },
          "b" : {
            "x" : 309,
            "y" : 1327
          },
          "type" : "BOX",
          "empty" : true,
          "centre" : {
            "x" : 303,
            "y" : 1321
          }
        }
      }
    } ]
  }, {
    "id" : 38464,
    "reactomeId" : 29370,
    "displayName" : "ADP",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 344,
      "y" : 1359
    },
    "minX" : 281,
    "maxX" : 372,
    "minY" : 1346,
    "maxY" : 1371,
    "prop" : {
      "x" : 317,
      "y" : 1347,
      "width" : 54,
      "height" : 24
    },
    "textPosition" : {
      "x" : 327,
      "y" : 1348
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 366,
          "y" : 1352
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 366,
          "y" : 1352
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 38462,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 314,
          "y" : 1357
        },
        "to" : {
          "x" : 281,
          "y" : 1355
        }
      } ],
      "stoichiometry" : {
        "value" : 16,
        "shape" : {
          "a" : {
            "x" : 291,
            "y" : 1350
          },
          "b" : {
            "x" : 303,
            "y" : 1362
          },
          "type" : "BOX",
          "empty" : true,
          "centre" : {
            "x" : 297,
            "y" : 1356
          }
        }
      },
      "endShape" : {
        "a" : {
          "x" : 307,
          "y" : 1361
        },
        "b" : {
          "x" : 314,
          "y" : 1357
        },
        "c" : {
          "x" : 307,
          "y" : 1353
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 307,
          "y" : 1353
        }
      }
    } ]
  }, {
    "id" : 38465,
    "reactomeId" : 9991370,
    "displayName" : "Activated FGFR1c homodimer",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 282,
      "y" : 1405
    },
    "minX" : 223,
    "maxX" : 348,
    "minY" : 1355,
    "maxY" : 1432,
    "prop" : {
      "x" : 223,
      "y" : 1379,
      "width" : 119,
      "height" : 53
    },
    "textPosition" : {
      "x" : 223,
      "y" : 1397
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 342,
          "y" : 1379
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 342,
          "y" : 1379
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 38462,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 281,
          "y" : 1376
        },
        "to" : {
          "x" : 281,
          "y" : 1355
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 277,
          "y" : 1369
        },
        "b" : {
          "x" : 281,
          "y" : 1376
        },
        "c" : {
          "x" : 285,
          "y" : 1369
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 285,
          "y" : 1369
        }
      }
    } ]
  }, {
    "id" : 38467,
    "reactomeId" : 9991388,
    "displayName" : "Klotho bound to FGF23",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 115,
      "y" : 1540
    },
    "minX" : 68,
    "maxX" : 282,
    "minY" : 1515,
    "maxY" : 1587,
    "prop" : {
      "x" : 68,
      "y" : 1521,
      "width" : 94,
      "height" : 38
    },
    "textPosition" : {
      "x" : 68,
      "y" : 1524
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 162,
          "y" : 1521
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 162,
          "y" : 1521
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 38466,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 165,
          "y" : 1553
        },
        "to" : {
          "x" : 282,
          "y" : 1587
        }
      } ],
      "stoichiometry" : {
        "value" : 2,
        "shape" : {
          "a" : {
            "x" : 217,
            "y" : 1564
          },
          "b" : {
            "x" : 229,
            "y" : 1576
          },
          "type" : "BOX",
          "empty" : true,
          "centre" : {
            "x" : 223,
            "y" : 1570
          }
        }
      }
    } ]
  }, {
    "id" : 38468,
    "reactomeId" : 190915,
    "displayName" : "HS",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 89,
      "y" : 1620
    },
    "minX" : 38,
    "maxX" : 282,
    "minY" : 1587,
    "maxY" : 1636,
    "prop" : {
      "x" : 38,
      "y" : 1604,
      "width" : 102,
      "height" : 32
    },
    "textPosition" : {
      "x" : 76,
      "y" : 1609
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 135,
          "y" : 1609
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 135,
          "y" : 1609
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 38466,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 143,
          "y" : 1611
        },
        "to" : {
          "x" : 282,
          "y" : 1587
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 38466,
      "type" : "ACTIVATOR",
      "segments" : [ {
        "from" : {
          "x" : 143,
          "y" : 1622
        },
        "to" : {
          "x" : 277,
          "y" : 1629
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 270,
          "y" : 1633
        },
        "b" : {
          "x" : 277,
          "y" : 1629
        },
        "c" : {
          "x" : 270,
          "y" : 1625
        },
        "type" : "ARROW",
        "empty" : true,
        "centre" : {
          "x" : 270,
          "y" : 1625
        }
      }
    } ]
  }, {
    "id" : 38469,
    "reactomeId" : 10000689,
    "displayName" : "FGF23 bound to Klotho and FGFR1c",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 287,
      "y" : 1687
    },
    "minX" : 233,
    "maxX" : 348,
    "minY" : 1655,
    "maxY" : 1756,
    "prop" : {
      "x" : 233,
      "y" : 1661,
      "width" : 109,
      "height" : 52
    },
    "textPosition" : {
      "x" : 232,
      "y" : 1664
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 342,
          "y" : 1661
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 342,
          "y" : 1661
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 38466,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 38470,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 288,
          "y" : 1716
        },
        "to" : {
          "x" : 290,
          "y" : 1736
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 38470,
      "type" : "CATALYST",
      "segments" : [ {
        "from" : {
          "x" : 271,
          "y" : 1716
        },
        "to" : {
          "x" : 253,
          "y" : 1745
        }
      }, {
        "from" : {
          "x" : 253,
          "y" : 1745
        },
        "to" : {
          "x" : 276,
          "y" : 1751
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 279,
          "y" : 1752
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 279,
          "y" : 1752
        }
      }
    } ]
  }, {
    "id" : 38471,
    "reactomeId" : 113592,
    "displayName" : "ATP",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 362,
      "y" : 1738
    },
    "minX" : 290,
    "maxX" : 391,
    "minY" : 1725,
    "maxY" : 1751,
    "prop" : {
      "x" : 334,
      "y" : 1726,
      "width" : 56,
      "height" : 25
    },
    "textPosition" : {
      "x" : 346,
      "y" : 1728
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 385,
          "y" : 1731
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 385,
          "y" : 1731
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 38470,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 331,
          "y" : 1737
        },
        "to" : {
          "x" : 290,
          "y" : 1736
        }
      } ],
      "stoichiometry" : {
        "value" : 16,
        "shape" : {
          "a" : {
            "x" : 304,
            "y" : 1730
          },
          "b" : {
            "x" : 316,
            "y" : 1742
          },
          "type" : "BOX",
          "empty" : true,
          "centre" : {
            "x" : 310,
            "y" : 1736
          }
        }
      }
    } ]
  }, {
    "id" : 38472,
    "reactomeId" : 29370,
    "displayName" : "ADP",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 363,
      "y" : 1779
    },
    "minX" : 293,
    "maxX" : 390,
    "minY" : 1766,
    "maxY" : 1791,
    "prop" : {
      "x" : 337,
      "y" : 1767,
      "width" : 52,
      "height" : 24
    },
    "textPosition" : {
      "x" : 346,
      "y" : 1768
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 384,
          "y" : 1772
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 384,
          "y" : 1772
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 38470,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 334,
          "y" : 1777
        },
        "to" : {
          "x" : 293,
          "y" : 1774
        }
      } ],
      "stoichiometry" : {
        "value" : 16,
        "shape" : {
          "a" : {
            "x" : 307,
            "y" : 1769
          },
          "b" : {
            "x" : 319,
            "y" : 1781
          },
          "type" : "BOX",
          "empty" : true,
          "centre" : {
            "x" : 313,
            "y" : 1775
          }
        }
      },
      "endShape" : {
        "a" : {
          "x" : 327,
          "y" : 1780
        },
        "b" : {
          "x" : 334,
          "y" : 1777
        },
        "c" : {
          "x" : 327,
          "y" : 1773
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 327,
          "y" : 1773
        }
      }
    } ]
  }, {
    "id" : 38473,
    "reactomeId" : 9991390,
    "displayName" : "Activated FGFR1c bound to FGF23:Klotho",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 300,
      "y" : 1822
    },
    "minX" : 246,
    "maxX" : 361,
    "minY" : 1774,
    "maxY" : 1849,
    "prop" : {
      "x" : 246,
      "y" : 1796,
      "width" : 109,
      "height" : 53
    },
    "textPosition" : {
      "x" : 247,
      "y" : 1800
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 355,
          "y" : 1796
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 355,
          "y" : 1796
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 38470,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 296,
          "y" : 1793
        },
        "to" : {
          "x" : 293,
          "y" : 1774
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 291,
          "y" : 1787
        },
        "b" : {
          "x" : 296,
          "y" : 1793
        },
        "c" : {
          "x" : 299,
          "y" : 1786
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 299,
          "y" : 1786
        }
      }
    } ]
  }, {
    "id" : 38475,
    "reactomeId" : 9999614,
    "displayName" : "GRB2:GAB1",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 3921,
      "y" : 748
    },
    "minX" : 3882,
    "maxX" : 3977,
    "minY" : 717,
    "maxY" : 759,
    "prop" : {
      "x" : 3882,
      "y" : 737,
      "width" : 79,
      "height" : 22
    },
    "textPosition" : {
      "x" : 3882,
      "y" : 738
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 3961,
          "y" : 737
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 3961,
          "y" : 737
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 38474,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 3940,
          "y" : 734
        },
        "to" : {
          "x" : 3977,
          "y" : 717
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 38476,
    "reactomeId" : 9989230,
    "displayName" : "Pik3r1",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 4054,
      "y" : 753
    },
    "minX" : 3977,
    "maxX" : 4108,
    "minY" : 717,
    "maxY" : 765,
    "prop" : {
      "x" : 4006,
      "y" : 742,
      "width" : 96,
      "height" : 23
    },
    "textPosition" : {
      "x" : 4030,
      "y" : 743
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 4102,
          "y" : 742
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 4102,
          "y" : 742
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 38474,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 4029,
          "y" : 739
        },
        "to" : {
          "x" : 3977,
          "y" : 717
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 38477,
    "reactomeId" : 9999752,
    "displayName" : "GRB2:GAB1:PIK3R1",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 3962,
      "y" : 626
    },
    "minX" : 3920,
    "maxX" : 4011,
    "minY" : 321,
    "maxY" : 645,
    "prop" : {
      "x" : 3920,
      "y" : 607,
      "width" : 85,
      "height" : 38
    },
    "textPosition" : {
      "x" : 3921,
      "y" : 610
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 4005,
          "y" : 607
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 4005,
          "y" : 607
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 38474,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 38563,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 3960,
          "y" : 604
        },
        "to" : {
          "x" : 3945,
          "y" : 321
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 38575,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 3964,
          "y" : 604
        },
        "to" : {
          "x" : 3980,
          "y" : 504
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 38479,
    "reactomeId" : 10029805,
    "displayName" : "PP2A(A:C):Y55/Y227-pSPRY2",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 6157,
      "y" : 1210
    },
    "minX" : 5975,
    "maxX" : 6239,
    "minY" : 1187,
    "maxY" : 1519,
    "prop" : {
      "x" : 6082,
      "y" : 1193,
      "width" : 151,
      "height" : 35
    },
    "textPosition" : {
      "x" : 6089,
      "y" : 1193
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 6233,
          "y" : 1193
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 6233,
          "y" : 1193
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 38478,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 6157,
          "y" : 1231
        },
        "to" : {
          "x" : 6157,
          "y" : 1265
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 38482,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 6192,
          "y" : 1231
        },
        "to" : {
          "x" : 6231,
          "y" : 1246
        }
      }, {
        "from" : {
          "x" : 6231,
          "y" : 1246
        },
        "to" : {
          "x" : 6228,
          "y" : 1456
        }
      }, {
        "from" : {
          "x" : 6228,
          "y" : 1456
        },
        "to" : {
          "x" : 6066,
          "y" : 1519
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 38491,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 6079,
          "y" : 1203
        },
        "to" : {
          "x" : 5995,
          "y" : 1195
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 6072,
          "y" : 1206
        },
        "b" : {
          "x" : 6079,
          "y" : 1203
        },
        "c" : {
          "x" : 6072,
          "y" : 1198
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 6072,
          "y" : 1198
        }
      }
    }, {
      "edgeId" : 38513,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 6098,
          "y" : 1231
        },
        "to" : {
          "x" : 5975,
          "y" : 1264
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 6092,
          "y" : 1237
        },
        "b" : {
          "x" : 6098,
          "y" : 1231
        },
        "c" : {
          "x" : 6090,
          "y" : 1229
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 6090,
          "y" : 1229
        }
      }
    } ]
  }, {
    "id" : 38480,
    "reactomeId" : 9989218,
    "displayName" : "Grb2",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 6055,
      "y" : 1327
    },
    "minX" : 5975,
    "maxX" : 6157,
    "minY" : 1264,
    "maxY" : 1348,
    "prop" : {
      "x" : 6026,
      "y" : 1306,
      "width" : 59,
      "height" : 42
    },
    "textPosition" : {
      "x" : 6036,
      "y" : 1316
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 6085,
          "y" : 1306
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 6085,
          "y" : 1306
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 38478,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 6088,
          "y" : 1309
        },
        "to" : {
          "x" : 6157,
          "y" : 1265
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 38513,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 6028,
          "y" : 1303
        },
        "to" : {
          "x" : 5975,
          "y" : 1264
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 6020,
          "y" : 1302
        },
        "b" : {
          "x" : 6028,
          "y" : 1303
        },
        "c" : {
          "x" : 6025,
          "y" : 1296
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 6025,
          "y" : 1296
        }
      }
    } ]
  }, {
    "id" : 38481,
    "reactomeId" : 10029810,
    "displayName" : "PPA2A (A:C):Y55/Y227 p-SPRY2:GRB2",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 6155,
      "y" : 1423
    },
    "minX" : 6091,
    "maxX" : 6225,
    "minY" : 1392,
    "maxY" : 1448,
    "prop" : {
      "x" : 6091,
      "y" : 1398,
      "width" : 128,
      "height" : 50
    },
    "textPosition" : {
      "x" : 6092,
      "y" : 1399
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 6219,
          "y" : 1398
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 6219,
          "y" : 1398
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 38478,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 38513,
      "type" : "INPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 38483,
    "reactomeId" : 9999882,
    "displayName" : "CBL",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 6056,
      "y" : 1475
    },
    "minX" : 5884,
    "maxX" : 6088,
    "minY" : 1458,
    "maxY" : 1949,
    "prop" : {
      "x" : 6030,
      "y" : 1464,
      "width" : 52,
      "height" : 23
    },
    "textPosition" : {
      "x" : 6041,
      "y" : 1465
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 6082,
          "y" : 1464
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 6082,
          "y" : 1464
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 38482,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 6058,
          "y" : 1490
        },
        "to" : {
          "x" : 6066,
          "y" : 1519
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 38489,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 6027,
          "y" : 1483
        },
        "to" : {
          "x" : 5884,
          "y" : 1529
        }
      }, {
        "from" : {
          "x" : 5884,
          "y" : 1529
        },
        "to" : {
          "x" : 5888,
          "y" : 1948
        }
      }, {
        "from" : {
          "x" : 5888,
          "y" : 1948
        },
        "to" : {
          "x" : 6067,
          "y" : 1949
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 6022,
          "y" : 1489
        },
        "b" : {
          "x" : 6027,
          "y" : 1483
        },
        "c" : {
          "x" : 6019,
          "y" : 1481
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 6019,
          "y" : 1481
        }
      }
    } ]
  }, {
    "id" : 38484,
    "reactomeId" : 10022681,
    "displayName" : "Y55/Y227-pSPRY2:CBL",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 6142,
      "y" : 1672
    },
    "minX" : 6063,
    "maxX" : 6234,
    "minY" : 1568,
    "maxY" : 1774,
    "prop" : {
      "x" : 6063,
      "y" : 1654,
      "width" : 158,
      "height" : 37
    },
    "textPosition" : {
      "x" : 6070,
      "y" : 1670
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 6221,
          "y" : 1654
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 6221,
          "y" : 1654
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 38482,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 6128,
          "y" : 1651
        },
        "to" : {
          "x" : 6067,
          "y" : 1568
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 6121,
          "y" : 1648
        },
        "b" : {
          "x" : 6128,
          "y" : 1651
        },
        "c" : {
          "x" : 6127,
          "y" : 1643
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 6127,
          "y" : 1643
        }
      }
    }, {
      "edgeId" : 38486,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 6141,
          "y" : 1694
        },
        "to" : {
          "x" : 6141,
          "y" : 1737
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 38486,
      "type" : "CATALYST",
      "segments" : [ {
        "from" : {
          "x" : 6167,
          "y" : 1694
        },
        "to" : {
          "x" : 6234,
          "y" : 1738
        }
      }, {
        "from" : {
          "x" : 6234,
          "y" : 1738
        },
        "to" : {
          "x" : 6162,
          "y" : 1769
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 6158,
          "y" : 1770
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 6158,
          "y" : 1770
        }
      }
    } ]
  }, {
    "id" : 38485,
    "reactomeId" : 10022657,
    "displayName" : "PP2A (A:C)",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 6004,
      "y" : 1625
    },
    "minX" : 5948,
    "maxX" : 6067,
    "minY" : 1568,
    "maxY" : 1638,
    "prop" : {
      "x" : 5948,
      "y" : 1612,
      "width" : 113,
      "height" : 26
    },
    "textPosition" : {
      "x" : 5967,
      "y" : 1617
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 6061,
          "y" : 1612
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 6061,
          "y" : 1612
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 38482,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 6018,
          "y" : 1609
        },
        "to" : {
          "x" : 6067,
          "y" : 1568
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 6021,
          "y" : 1601
        },
        "b" : {
          "x" : 6018,
          "y" : 1609
        },
        "c" : {
          "x" : 6026,
          "y" : 1608
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 6026,
          "y" : 1608
        }
      }
    } ]
  }, {
    "id" : 38487,
    "reactomeId" : 9985374,
    "displayName" : "Ub",
    "schemaClass" : "DefinedSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 6003,
      "y" : 1732
    },
    "minX" : 5974,
    "maxX" : 6141,
    "minY" : 1722,
    "maxY" : 1743,
    "prop" : {
      "x" : 5974,
      "y" : 1722,
      "width" : 58,
      "height" : 21
    },
    "textPosition" : {
      "x" : 5990,
      "y" : 1722
    },
    "connectors" : [ {
      "edgeId" : 38486,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 6038,
          "y" : 1733
        },
        "to" : {
          "x" : 6141,
          "y" : 1737
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 38488,
    "reactomeId" : 10022683,
    "displayName" : "Ub:Y55/Y227-pSPRY2:CBL",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 6150,
      "y" : 1863
    },
    "minX" : 6074,
    "maxX" : 6233,
    "minY" : 1835,
    "maxY" : 1885,
    "prop" : {
      "x" : 6074,
      "y" : 1841,
      "width" : 153,
      "height" : 44
    },
    "textPosition" : {
      "x" : 6079,
      "y" : 1850
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 6227,
          "y" : 1841
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 6227,
          "y" : 1841
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 38486,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 38489,
      "type" : "INPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 38490,
    "reactomeId" : 10029814,
    "displayName" : "Ub-(Y55/Y227)p-SPRY2",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 6022,
      "y" : 2041
    },
    "minX" : 5965,
    "maxX" : 6086,
    "minY" : 1949,
    "maxY" : 2059,
    "prop" : {
      "x" : 5965,
      "y" : 2023,
      "width" : 115,
      "height" : 36
    },
    "textPosition" : {
      "x" : 5968,
      "y" : 2024
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 6080,
          "y" : 2023
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 6080,
          "y" : 2023
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 38489,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 6030,
          "y" : 2020
        },
        "to" : {
          "x" : 6067,
          "y" : 1949
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 6030,
          "y" : 2012
        },
        "b" : {
          "x" : 6030,
          "y" : 2020
        },
        "c" : {
          "x" : 6037,
          "y" : 2016
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 6037,
          "y" : 2016
        }
      }
    } ]
  }, {
    "id" : 38492,
    "reactomeId" : 10022659,
    "displayName" : "PP2A(A:C):SPRY2",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 6148,
      "y" : 850
    },
    "minX" : 5834,
    "maxX" : 6204,
    "minY" : 825,
    "maxY" : 960,
    "prop" : {
      "x" : 6099,
      "y" : 831,
      "width" : 99,
      "height" : 39
    },
    "textPosition" : {
      "x" : 6111,
      "y" : 835
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 6198,
          "y" : 831
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 6198,
          "y" : 831
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 38491,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 6096,
          "y" : 864
        },
        "to" : {
          "x" : 5834,
          "y" : 941
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 38497,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 38502,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 6146,
          "y" : 873
        },
        "to" : {
          "x" : 6139,
          "y" : 960
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 38493,
    "reactomeId" : 113592,
    "displayName" : "ATP",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 5748,
      "y" : 917
    },
    "minX" : 5720,
    "maxX" : 5834,
    "minY" : 905,
    "maxY" : 941,
    "prop" : {
      "x" : 5720,
      "y" : 906,
      "width" : 56,
      "height" : 23
    },
    "textPosition" : {
      "x" : 5732,
      "y" : 907
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 5771,
          "y" : 911
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 5771,
          "y" : 911
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 38491,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 5779,
          "y" : 924
        },
        "to" : {
          "x" : 5834,
          "y" : 941
        }
      } ],
      "stoichiometry" : {
        "value" : 2,
        "shape" : {
          "a" : {
            "x" : 5800,
            "y" : 926
          },
          "b" : {
            "x" : 5812,
            "y" : 938
          },
          "type" : "BOX",
          "empty" : true,
          "centre" : {
            "x" : 5806,
            "y" : 932
          }
        }
      }
    } ]
  }, {
    "id" : 38494,
    "reactomeId" : 29370,
    "displayName" : "ADP",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 5922,
      "y" : 1220
    },
    "minX" : 5897,
    "maxX" : 5995,
    "minY" : 1195,
    "maxY" : 1231,
    "prop" : {
      "x" : 5897,
      "y" : 1210,
      "width" : 51,
      "height" : 21
    },
    "textPosition" : {
      "x" : 5906,
      "y" : 1210
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 5943,
          "y" : 1215
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 5943,
          "y" : 1215
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 38491,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 5951,
          "y" : 1211
        },
        "to" : {
          "x" : 5995,
          "y" : 1195
        }
      } ],
      "stoichiometry" : {
        "value" : 2,
        "shape" : {
          "a" : {
            "x" : 5967,
            "y" : 1197
          },
          "b" : {
            "x" : 5979,
            "y" : 1209
          },
          "type" : "BOX",
          "empty" : true,
          "centre" : {
            "x" : 5973,
            "y" : 1203
          }
        }
      },
      "endShape" : {
        "a" : {
          "x" : 5956,
          "y" : 1205
        },
        "b" : {
          "x" : 5951,
          "y" : 1211
        },
        "c" : {
          "x" : 5959,
          "y" : 1212
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 5959,
          "y" : 1212
        }
      }
    } ]
  }, {
    "id" : 38495,
    "reactomeId" : 9999799,
    "displayName" : "SRC-1",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 5781,
      "y" : 1062
    },
    "minX" : 5740,
    "maxX" : 5833,
    "minY" : 1042,
    "maxY" : 1135,
    "prop" : {
      "x" : 5740,
      "y" : 1048,
      "width" : 83,
      "height" : 29
    },
    "textPosition" : {
      "x" : 5759,
      "y" : 1052
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 5823,
          "y" : 1048
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 5823,
          "y" : 1048
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 38491,
      "type" : "CATALYST",
      "segments" : [ {
        "from" : {
          "x" : 5791,
          "y" : 1080
        },
        "to" : {
          "x" : 5827,
          "y" : 1128
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 5829,
          "y" : 1131
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 5829,
          "y" : 1131
        }
      }
    } ]
  }, {
    "id" : 38496,
    "reactomeId" : 10022665,
    "displayName" : "PP2A(A:C):S112/S121-pSPRY2",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 6150,
      "y" : 1131
    },
    "minX" : 5845,
    "maxX" : 6215,
    "minY" : 1035,
    "maxY" : 1156,
    "prop" : {
      "x" : 6092,
      "y" : 1107,
      "width" : 117,
      "height" : 49
    },
    "textPosition" : {
      "x" : 6110,
      "y" : 1107
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 6209,
          "y" : 1107
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 6209,
          "y" : 1107
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 38491,
      "type" : "INHIBITOR",
      "segments" : [ {
        "from" : {
          "x" : 6089,
          "y" : 1132
        },
        "to" : {
          "x" : 5845,
          "y" : 1141
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 5845,
          "y" : 1137
        },
        "b" : {
          "x" : 5845,
          "y" : 1145
        },
        "c" : {
          "x" : 5845,
          "y" : 1141
        },
        "type" : "STOP",
        "centre" : {
          "x" : 5845,
          "y" : 1141
        }
      }
    }, {
      "edgeId" : 38502,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 6147,
          "y" : 1104
        },
        "to" : {
          "x" : 6142,
          "y" : 1035
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 6143,
          "y" : 1097
        },
        "b" : {
          "x" : 6147,
          "y" : 1104
        },
        "c" : {
          "x" : 6150,
          "y" : 1097
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 6150,
          "y" : 1097
        }
      }
    } ]
  }, {
    "id" : 38498,
    "reactomeId" : 10029789,
    "displayName" : "PPA2A(A:C):SPRY2",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 5846,
      "y" : 876
    },
    "minX" : 5792,
    "maxX" : 5906,
    "minY" : 810,
    "maxY" : 894,
    "prop" : {
      "x" : 5792,
      "y" : 859,
      "width" : 108,
      "height" : 35
    },
    "textPosition" : {
      "x" : 5805,
      "y" : 859
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 5900,
          "y" : 859
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 5900,
          "y" : 859
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 38497,
      "type" : "INPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 38499,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 5832,
          "y" : 856
        },
        "to" : {
          "x" : 5795,
          "y" : 810
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 5825,
          "y" : 853
        },
        "b" : {
          "x" : 5832,
          "y" : 856
        },
        "c" : {
          "x" : 5831,
          "y" : 848
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 5831,
          "y" : 848
        }
      }
    } ]
  }, {
    "id" : 38500,
    "reactomeId" : 10029823,
    "displayName" : "PPA2A (A:C):S112/S115 p-SPRY2",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 5791,
      "y" : 684
    },
    "minX" : 5714,
    "maxX" : 5874,
    "minY" : 659,
    "maxY" : 771,
    "prop" : {
      "x" : 5714,
      "y" : 665,
      "width" : 154,
      "height" : 38
    },
    "textPosition" : {
      "x" : 5712,
      "y" : 668
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 5868,
          "y" : 665
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 5868,
          "y" : 665
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 38499,
      "type" : "INPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 38499,
      "type" : "CATALYST",
      "segments" : [ {
        "from" : {
          "x" : 5777,
          "y" : 706
        },
        "to" : {
          "x" : 5751,
          "y" : 741
        }
      }, {
        "from" : {
          "x" : 5751,
          "y" : 741
        },
        "to" : {
          "x" : 5780,
          "y" : 765
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 5783,
          "y" : 767
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 5783,
          "y" : 767
        }
      }
    } ]
  }, {
    "id" : 38501,
    "reactomeId" : 29372,
    "displayName" : "Pi",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 5866,
      "y" : 832
    },
    "minX" : 5795,
    "maxX" : 5890,
    "minY" : 810,
    "maxY" : 844,
    "prop" : {
      "x" : 5844,
      "y" : 820,
      "width" : 45,
      "height" : 24
    },
    "textPosition" : {
      "x" : 5857,
      "y" : 821
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 5884,
          "y" : 825
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 5884,
          "y" : 825
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 38499,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 5841,
          "y" : 825
        },
        "to" : {
          "x" : 5795,
          "y" : 810
        }
      } ],
      "stoichiometry" : {
        "value" : 2,
        "shape" : {
          "a" : {
            "x" : 5812,
            "y" : 811
          },
          "b" : {
            "x" : 5824,
            "y" : 823
          },
          "type" : "BOX",
          "empty" : true,
          "centre" : {
            "x" : 5818,
            "y" : 817
          }
        }
      },
      "endShape" : {
        "a" : {
          "x" : 5833,
          "y" : 827
        },
        "b" : {
          "x" : 5841,
          "y" : 825
        },
        "c" : {
          "x" : 5836,
          "y" : 819
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 5836,
          "y" : 819
        }
      }
    } ]
  }, {
    "id" : 38503,
    "reactomeId" : 113592,
    "displayName" : "ATP",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 6193,
      "y" : 910
    },
    "minX" : 6139,
    "maxX" : 6214,
    "minY" : 895,
    "maxY" : 960,
    "prop" : {
      "x" : 6174,
      "y" : 896,
      "width" : 39,
      "height" : 29
    },
    "textPosition" : {
      "x" : 6178,
      "y" : 900
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 6208,
          "y" : 901
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 6208,
          "y" : 901
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 38502,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 6177,
          "y" : 928
        },
        "to" : {
          "x" : 6139,
          "y" : 960
        }
      } ],
      "stoichiometry" : {
        "value" : 2,
        "shape" : {
          "a" : {
            "x" : 6152,
            "y" : 938
          },
          "b" : {
            "x" : 6164,
            "y" : 950
          },
          "type" : "BOX",
          "empty" : true,
          "centre" : {
            "x" : 6158,
            "y" : 944
          }
        }
      }
    } ]
  }, {
    "id" : 38504,
    "reactomeId" : 29370,
    "displayName" : "ADP",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 6207,
      "y" : 1045
    },
    "minX" : 6142,
    "maxX" : 6228,
    "minY" : 1030,
    "maxY" : 1060,
    "prop" : {
      "x" : 6187,
      "y" : 1031,
      "width" : 40,
      "height" : 29
    },
    "textPosition" : {
      "x" : 6190,
      "y" : 1035
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 6222,
          "y" : 1036
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 6222,
          "y" : 1036
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 38502,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 6184,
          "y" : 1041
        },
        "to" : {
          "x" : 6142,
          "y" : 1035
        }
      } ],
      "stoichiometry" : {
        "value" : 2,
        "shape" : {
          "a" : {
            "x" : 6157,
            "y" : 1032
          },
          "b" : {
            "x" : 6169,
            "y" : 1044
          },
          "type" : "BOX",
          "empty" : true,
          "centre" : {
            "x" : 6163,
            "y" : 1038
          }
        }
      },
      "endShape" : {
        "a" : {
          "x" : 6177,
          "y" : 1044
        },
        "b" : {
          "x" : 6184,
          "y" : 1041
        },
        "c" : {
          "x" : 6178,
          "y" : 1036
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 6178,
          "y" : 1036
        }
      }
    } ]
  }, {
    "id" : 38505,
    "reactomeId" : 10022673,
    "displayName" : "phospho-p-T250,T255,T385,S437-MKNK1",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 5917,
      "y" : 993
    },
    "minX" : 5866,
    "maxX" : 6128,
    "minY" : 956,
    "maxY" : 1024,
    "prop" : {
      "x" : 5866,
      "y" : 962,
      "width" : 103,
      "height" : 62
    },
    "textPosition" : {
      "x" : 5878,
      "y" : 962
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 5969,
          "y" : 962
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 5969,
          "y" : 962
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 38502,
      "type" : "CATALYST",
      "segments" : [ {
        "from" : {
          "x" : 5972,
          "y" : 993
        },
        "to" : {
          "x" : 6120,
          "y" : 996
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 6124,
          "y" : 996
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 6124,
          "y" : 996
        }
      }
    } ]
  }, {
    "id" : 38507,
    "reactomeId" : 10029801,
    "displayName" : "S110/S120 p-SPRY2:B-RAF",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 3601,
      "y" : 1128
    },
    "minX" : 3553,
    "maxX" : 3655,
    "minY" : 1104,
    "maxY" : 1146,
    "prop" : {
      "x" : 3553,
      "y" : 1110,
      "width" : 96,
      "height" : 36
    },
    "textPosition" : {
      "x" : 3555,
      "y" : 1111
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 3649,
          "y" : 1110
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 3649,
          "y" : 1110
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 38506,
      "type" : "INPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 38510,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 38508,
    "reactomeId" : 10029795,
    "displayName" : "phospho-Spry2",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 3763,
      "y" : 1176
    },
    "minX" : 3688,
    "maxX" : 3844,
    "minY" : 1123,
    "maxY" : 1190,
    "prop" : {
      "x" : 3688,
      "y" : 1162,
      "width" : 150,
      "height" : 28
    },
    "textPosition" : {
      "x" : 3712,
      "y" : 1165
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 3838,
          "y" : 1162
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 3838,
          "y" : 1162
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 38506,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 3749,
          "y" : 1159
        },
        "to" : {
          "x" : 3711,
          "y" : 1123
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 3741,
          "y" : 1157
        },
        "b" : {
          "x" : 3749,
          "y" : 1159
        },
        "c" : {
          "x" : 3747,
          "y" : 1151
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 3747,
          "y" : 1151
        }
      }
    } ]
  }, {
    "id" : 38509,
    "reactomeId" : 10029799,
    "displayName" : "BRAF",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 3782,
      "y" : 1123
    },
    "minX" : 3711,
    "maxX" : 3810,
    "minY" : 1106,
    "maxY" : 1134,
    "prop" : {
      "x" : 3760,
      "y" : 1112,
      "width" : 44,
      "height" : 22
    },
    "textPosition" : {
      "x" : 3762,
      "y" : 1112
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 3804,
          "y" : 1112
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 3804,
          "y" : 1112
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 38506,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 3757,
          "y" : 1123
        },
        "to" : {
          "x" : 3711,
          "y" : 1123
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 3750,
          "y" : 1127
        },
        "b" : {
          "x" : 3757,
          "y" : 1123
        },
        "c" : {
          "x" : 3750,
          "y" : 1119
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 3750,
          "y" : 1119
        }
      }
    } ]
  }, {
    "id" : 38511,
    "reactomeId" : 10029828,
    "displayName" : "SPRY2:B-RAF",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 3401,
      "y" : 1128
    },
    "minX" : 3353,
    "maxX" : 3456,
    "minY" : 1109,
    "maxY" : 1142,
    "prop" : {
      "x" : 3353,
      "y" : 1115,
      "width" : 97,
      "height" : 27
    },
    "textPosition" : {
      "x" : 3358,
      "y" : 1121
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 3450,
          "y" : 1115
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 3450,
          "y" : 1115
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 38510,
      "type" : "INPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 38512,
    "reactomeId" : 9997684,
    "displayName" : "p-T,Y MAPK dimers",
    "schemaClass" : "DefinedSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 3407,
      "y" : 1070
    },
    "minX" : 2680,
    "maxX" : 3518,
    "minY" : 551,
    "maxY" : 1121,
    "prop" : {
      "x" : 3344,
      "y" : 1056,
      "width" : 127,
      "height" : 28
    },
    "textPosition" : {
      "x" : 3347,
      "y" : 1059
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "connectors" : [ {
      "edgeId" : 38510,
      "type" : "ACTIVATOR",
      "segments" : [ {
        "from" : {
          "x" : 3477,
          "y" : 1078
        },
        "to" : {
          "x" : 3500,
          "y" : 1082
        }
      }, {
        "from" : {
          "x" : 3500,
          "y" : 1082
        },
        "to" : {
          "x" : 3517,
          "y" : 1121
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 3511,
          "y" : 1116
        },
        "b" : {
          "x" : 3517,
          "y" : 1121
        },
        "c" : {
          "x" : 3518,
          "y" : 1113
        },
        "type" : "ARROW",
        "empty" : true,
        "centre" : {
          "x" : 3518,
          "y" : 1113
        }
      }
    }, {
      "edgeId" : 38579,
      "type" : "CATALYST",
      "segments" : [ {
        "from" : {
          "x" : 3338,
          "y" : 1069
        },
        "to" : {
          "x" : 2680,
          "y" : 1066
        }
      }, {
        "from" : {
          "x" : 2680,
          "y" : 1066
        },
        "to" : {
          "x" : 2685,
          "y" : 559
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 2685,
          "y" : 555
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 2685,
          "y" : 555
        }
      }
    } ]
  }, {
    "id" : 38514,
    "reactomeId" : 9996589,
    "displayName" : "PTPN11",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 3353,
      "y" : 628
    },
    "minX" : 3316,
    "maxX" : 5977,
    "minY" : 389,
    "maxY" : 1375,
    "prop" : {
      "x" : 3316,
      "y" : 615,
      "width" : 75,
      "height" : 27
    },
    "textPosition" : {
      "x" : 3325,
      "y" : 618
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 3391,
          "y" : 615
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 3391,
          "y" : 615
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 38537,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 3351,
          "y" : 612
        },
        "to" : {
          "x" : 3325,
          "y" : 389
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 38513,
      "type" : "CATALYST",
      "segments" : [ {
        "from" : {
          "x" : 3387,
          "y" : 645
        },
        "to" : {
          "x" : 5282,
          "y" : 1375
        }
      }, {
        "from" : {
          "x" : 5282,
          "y" : 1375
        },
        "to" : {
          "x" : 5969,
          "y" : 1360
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 5973,
          "y" : 1360
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 5973,
          "y" : 1360
        }
      }
    } ]
  }, {
    "id" : 38516,
    "reactomeId" : 10057950,
    "displayName" : "Frs2",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 2235,
      "y" : 399
    },
    "minX" : 2190,
    "maxX" : 2286,
    "minY" : 341,
    "maxY" : 411,
    "prop" : {
      "x" : 2190,
      "y" : 387,
      "width" : 90,
      "height" : 24
    },
    "textPosition" : {
      "x" : 2217,
      "y" : 388
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 2280,
          "y" : 387
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 2280,
          "y" : 387
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 38515,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 2232,
          "y" : 384
        },
        "to" : {
          "x" : 2225,
          "y" : 341
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 38517,
    "reactomeId" : 10044112,
    "displayName" : "Activated FGFR1",
    "schemaClass" : "DefinedSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 2098,
      "y" : 414
    },
    "minX" : 1499,
    "maxX" : 2255,
    "minY" : 141,
    "maxY" : 543,
    "prop" : {
      "x" : 2043,
      "y" : 403,
      "width" : 110,
      "height" : 22
    },
    "textPosition" : {
      "x" : 2043,
      "y" : 403
    },
    "connectors" : [ {
      "edgeId" : 38597,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 2096,
          "y" : 431
        },
        "to" : {
          "x" : 2084,
          "y" : 543
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 38543,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 2077,
          "y" : 397
        },
        "to" : {
          "x" : 1966,
          "y" : 343
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 38551,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 2098,
          "y" : 397
        },
        "to" : {
          "x" : 2104,
          "y" : 149
        }
      }, {
        "from" : {
          "x" : 2104,
          "y" : 149
        },
        "to" : {
          "x" : 1499,
          "y" : 141
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 2094,
          "y" : 390
        },
        "b" : {
          "x" : 2098,
          "y" : 397
        },
        "c" : {
          "x" : 2102,
          "y" : 390
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 2102,
          "y" : 390
        }
      }
    }, {
      "edgeId" : 38553,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 2123,
          "y" : 431
        },
        "to" : {
          "x" : 2249,
          "y" : 478
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 38515,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 2117,
          "y" : 397
        },
        "to" : {
          "x" : 2225,
          "y" : 341
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 38519,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 2109,
          "y" : 397
        },
        "to" : {
          "x" : 2255,
          "y" : 258
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 38518,
    "reactomeId" : 10058071,
    "displayName" : "Activated FGFR1:FRS2",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 2388,
      "y" : 347
    },
    "minX" : 2335,
    "maxX" : 2642,
    "minY" : 323,
    "maxY" : 543,
    "prop" : {
      "x" : 2335,
      "y" : 329,
      "width" : 107,
      "height" : 36
    },
    "textPosition" : {
      "x" : 2347,
      "y" : 330
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 2442,
          "y" : 329
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 2442,
          "y" : 329
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 38579,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 2411,
          "y" : 368
        },
        "to" : {
          "x" : 2642,
          "y" : 543
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 38515,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 38522,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 2445,
          "y" : 351
        },
        "to" : {
          "x" : 2501,
          "y" : 356
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 38522,
      "type" : "CATALYST",
      "segments" : [ {
        "from" : {
          "x" : 2421,
          "y" : 368
        },
        "to" : {
          "x" : 2470,
          "y" : 391
        }
      }, {
        "from" : {
          "x" : 2470,
          "y" : 391
        },
        "to" : {
          "x" : 2514,
          "y" : 363
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 2517,
          "y" : 361
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 2517,
          "y" : 361
        }
      }
    } ]
  }, {
    "id" : 38520,
    "reactomeId" : 10058086,
    "displayName" : "Frs3",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 2202,
      "y" : 222
    },
    "minX" : 2158,
    "maxX" : 2255,
    "minY" : 203,
    "maxY" : 258,
    "prop" : {
      "x" : 2158,
      "y" : 209,
      "width" : 88,
      "height" : 27
    },
    "textPosition" : {
      "x" : 2184,
      "y" : 212
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 2246,
          "y" : 209
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 2246,
          "y" : 209
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 38519,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 2221,
          "y" : 239
        },
        "to" : {
          "x" : 2255,
          "y" : 258
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 38521,
    "reactomeId" : 10058088,
    "displayName" : "Activated FGFR1:FRS3",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 2386,
      "y" : 258
    },
    "minX" : 2332,
    "maxX" : 2527,
    "minY" : 165,
    "maxY" : 285,
    "prop" : {
      "x" : 2332,
      "y" : 232,
      "width" : 109,
      "height" : 53
    },
    "textPosition" : {
      "x" : 2345,
      "y" : 250
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 2441,
          "y" : 232
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 2441,
          "y" : 232
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 38519,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 38526,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 2444,
          "y" : 255
        },
        "to" : {
          "x" : 2507,
          "y" : 253
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 38526,
      "type" : "CATALYST",
      "segments" : [ {
        "from" : {
          "x" : 2402,
          "y" : 229
        },
        "to" : {
          "x" : 2444,
          "y" : 165
        }
      }, {
        "from" : {
          "x" : 2444,
          "y" : 165
        },
        "to" : {
          "x" : 2520,
          "y" : 242
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 2523,
          "y" : 244
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 2523,
          "y" : 244
        }
      }
    } ]
  }, {
    "id" : 38523,
    "reactomeId" : 113592,
    "displayName" : "ATP",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 2482,
      "y" : 317
    },
    "minX" : 2447,
    "maxX" : 2518,
    "minY" : 253,
    "maxY" : 356,
    "prop" : {
      "x" : 2447,
      "y" : 303,
      "width" : 70,
      "height" : 29
    },
    "textPosition" : {
      "x" : 2466,
      "y" : 307
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 2512,
          "y" : 308
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 2512,
          "y" : 308
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 38522,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 2489,
          "y" : 335
        },
        "to" : {
          "x" : 2501,
          "y" : 356
        }
      } ],
      "stoichiometry" : {
        "value" : 6,
        "shape" : {
          "a" : {
            "x" : 2489,
            "y" : 339
          },
          "b" : {
            "x" : 2501,
            "y" : 351
          },
          "type" : "BOX",
          "empty" : true,
          "centre" : {
            "x" : 2495,
            "y" : 345
          }
        }
      }
    }, {
      "edgeId" : 38526,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 2487,
          "y" : 300
        },
        "to" : {
          "x" : 2507,
          "y" : 253
        }
      } ],
      "stoichiometry" : {
        "value" : 5,
        "shape" : {
          "a" : {
            "x" : 2491,
            "y" : 270
          },
          "b" : {
            "x" : 2503,
            "y" : 282
          },
          "type" : "BOX",
          "empty" : true,
          "centre" : {
            "x" : 2497,
            "y" : 276
          }
        }
      }
    } ]
  }, {
    "id" : 38524,
    "reactomeId" : 29370,
    "displayName" : "ADP",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 2592,
      "y" : 320
    },
    "minX" : 2556,
    "maxX" : 2629,
    "minY" : 252,
    "maxY" : 355,
    "prop" : {
      "x" : 2556,
      "y" : 305,
      "width" : 72,
      "height" : 30
    },
    "textPosition" : {
      "x" : 2575,
      "y" : 309
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 2623,
          "y" : 310
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 2623,
          "y" : 310
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 38522,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 2577,
          "y" : 338
        },
        "to" : {
          "x" : 2557,
          "y" : 355
        }
      } ],
      "stoichiometry" : {
        "value" : 6,
        "shape" : {
          "a" : {
            "x" : 2561,
            "y" : 340
          },
          "b" : {
            "x" : 2573,
            "y" : 352
          },
          "type" : "BOX",
          "empty" : true,
          "centre" : {
            "x" : 2567,
            "y" : 346
          }
        }
      },
      "endShape" : {
        "a" : {
          "x" : 2574,
          "y" : 346
        },
        "b" : {
          "x" : 2577,
          "y" : 338
        },
        "c" : {
          "x" : 2569,
          "y" : 339
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 2569,
          "y" : 339
        }
      }
    }, {
      "edgeId" : 38526,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 2584,
          "y" : 302
        },
        "to" : {
          "x" : 2558,
          "y" : 252
        }
      } ],
      "stoichiometry" : {
        "value" : 5,
        "shape" : {
          "a" : {
            "x" : 2565,
            "y" : 271
          },
          "b" : {
            "x" : 2577,
            "y" : 283
          },
          "type" : "BOX",
          "empty" : true,
          "centre" : {
            "x" : 2571,
            "y" : 277
          }
        }
      },
      "endShape" : {
        "a" : {
          "x" : 2577,
          "y" : 298
        },
        "b" : {
          "x" : 2584,
          "y" : 302
        },
        "c" : {
          "x" : 2584,
          "y" : 294
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 2584,
          "y" : 294
        }
      }
    } ]
  }, {
    "id" : 38525,
    "reactomeId" : 10044114,
    "displayName" : "Activated FGFR1:p-FRS2",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 2702,
      "y" : 367
    },
    "minX" : 2557,
    "maxX" : 3945,
    "minY" : 317,
    "maxY" : 393,
    "prop" : {
      "x" : 2643,
      "y" : 342,
      "width" : 119,
      "height" : 51
    },
    "textPosition" : {
      "x" : 2646,
      "y" : 358
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 2762,
          "y" : 342
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 2762,
          "y" : 342
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 38563,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 2765,
          "y" : 351
        },
        "to" : {
          "x" : 2889,
          "y" : 317
        }
      }, {
        "from" : {
          "x" : 2889,
          "y" : 317
        },
        "to" : {
          "x" : 3945,
          "y" : 321
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 38522,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 2640,
          "y" : 362
        },
        "to" : {
          "x" : 2557,
          "y" : 355
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 2633,
          "y" : 365
        },
        "b" : {
          "x" : 2640,
          "y" : 362
        },
        "c" : {
          "x" : 2633,
          "y" : 357
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 2633,
          "y" : 357
        }
      }
    } ]
  }, {
    "id" : 38527,
    "reactomeId" : 10057941,
    "displayName" : "Activated FGFR1:p-FRS3",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 2708,
      "y" : 254
    },
    "minX" : 2558,
    "maxX" : 2772,
    "minY" : 223,
    "maxY" : 279,
    "prop" : {
      "x" : 2651,
      "y" : 229,
      "width" : 115,
      "height" : 50
    },
    "textPosition" : {
      "x" : 2652,
      "y" : 244
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 2766,
          "y" : 229
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 2766,
          "y" : 229
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 38526,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 2648,
          "y" : 253
        },
        "to" : {
          "x" : 2558,
          "y" : 252
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 2641,
          "y" : 257
        },
        "b" : {
          "x" : 2648,
          "y" : 253
        },
        "c" : {
          "x" : 2641,
          "y" : 249
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 2641,
          "y" : 249
        }
      }
    } ]
  }, {
    "id" : 38529,
    "reactomeId" : 9989223,
    "displayName" : "GRB2-1:SOS1",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 2944,
      "y" : 621
    },
    "minX" : 2898,
    "maxX" : 2996,
    "minY" : 496,
    "maxY" : 706,
    "prop" : {
      "x" : 2898,
      "y" : 607,
      "width" : 92,
      "height" : 28
    },
    "textPosition" : {
      "x" : 2899,
      "y" : 614
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 2990,
          "y" : 607
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 2990,
          "y" : 607
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 38528,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 2947,
          "y" : 604
        },
        "to" : {
          "x" : 2974,
          "y" : 496
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 38560,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 2951,
          "y" : 638
        },
        "to" : {
          "x" : 2989,
          "y" : 706
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 38530,
    "reactomeId" : 10057943,
    "displayName" : "Activated FGFR1:p-FRS",
    "schemaClass" : "DefinedSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 2884,
      "y" : 449
    },
    "minX" : 2822,
    "maxX" : 3325,
    "minY" : 382,
    "maxY" : 496,
    "prop" : {
      "x" : 2822,
      "y" : 426,
      "width" : 124,
      "height" : 46
    },
    "textPosition" : {
      "x" : 2827,
      "y" : 431
    },
    "connectors" : [ {
      "edgeId" : 38528,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 2928,
          "y" : 478
        },
        "to" : {
          "x" : 2974,
          "y" : 496
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 38537,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 2923,
          "y" : 420
        },
        "to" : {
          "x" : 2999,
          "y" : 382
        }
      }, {
        "from" : {
          "x" : 2999,
          "y" : 382
        },
        "to" : {
          "x" : 3325,
          "y" : 389
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 38531,
    "reactomeId" : 10057945,
    "displayName" : "Activated FGFR1:p-FRS2:GRB2:SOS1",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 3124,
      "y" : 488
    },
    "minX" : 3069,
    "maxX" : 3293,
    "minY" : 455,
    "maxY" : 808,
    "prop" : {
      "x" : 3069,
      "y" : 461,
      "width" : 110,
      "height" : 54
    },
    "textPosition" : {
      "x" : 3075,
      "y" : 466
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 3179,
          "y" : 461
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 3179,
          "y" : 461
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 38528,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 38532,
      "type" : "CATALYST",
      "segments" : [ {
        "from" : {
          "x" : 3182,
          "y" : 502
        },
        "to" : {
          "x" : 3293,
          "y" : 534
        }
      }, {
        "from" : {
          "x" : 3293,
          "y" : 534
        },
        "to" : {
          "x" : 3251,
          "y" : 800
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 3251,
          "y" : 804
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 3251,
          "y" : 804
        }
      }
    } ]
  }, {
    "id" : 38533,
    "reactomeId" : 9999804,
    "displayName" : "p21 RAS:GDP",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 3086,
      "y" : 786
    },
    "minX" : 3046,
    "maxX" : 3218,
    "minY" : 749,
    "maxY" : 815,
    "prop" : {
      "x" : 3046,
      "y" : 767,
      "width" : 80,
      "height" : 39
    },
    "textPosition" : {
      "x" : 3054,
      "y" : 771
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 3126,
          "y" : 767
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 3126,
          "y" : 767
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 38532,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 3129,
          "y" : 794
        },
        "to" : {
          "x" : 3218,
          "y" : 815
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 38600,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 3129,
          "y" : 773
        },
        "to" : {
          "x" : 3201,
          "y" : 749
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 38562,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 3129,
          "y" : 784
        },
        "to" : {
          "x" : 3211,
          "y" : 781
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 38534,
    "reactomeId" : 29438,
    "displayName" : "GTP",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 3101,
      "y" : 887
    },
    "minX" : 3069,
    "maxX" : 3218,
    "minY" : 749,
    "maxY" : 902,
    "prop" : {
      "x" : 3069,
      "y" : 873,
      "width" : 64,
      "height" : 29
    },
    "textPosition" : {
      "x" : 3085,
      "y" : 877
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 3128,
          "y" : 878
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 3128,
          "y" : 878
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 38532,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 3124,
          "y" : 870
        },
        "to" : {
          "x" : 3218,
          "y" : 815
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 38600,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 3111,
          "y" : 870
        },
        "to" : {
          "x" : 3201,
          "y" : 749
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 38562,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 3116,
          "y" : 870
        },
        "to" : {
          "x" : 3211,
          "y" : 781
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 38535,
    "reactomeId" : 29420,
    "displayName" : "GDP",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 3353,
      "y" : 866
    },
    "minX" : 3294,
    "maxX" : 3386,
    "minY" : 749,
    "maxY" : 881,
    "prop" : {
      "x" : 3321,
      "y" : 852,
      "width" : 64,
      "height" : 29
    },
    "textPosition" : {
      "x" : 3336,
      "y" : 856
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 3380,
          "y" : 857
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 3380,
          "y" : 857
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 38532,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 3335,
          "y" : 849
        },
        "to" : {
          "x" : 3294,
          "y" : 817
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 3327,
          "y" : 848
        },
        "b" : {
          "x" : 3335,
          "y" : 849
        },
        "c" : {
          "x" : 3332,
          "y" : 842
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 3332,
          "y" : 842
        }
      }
    }, {
      "edgeId" : 38600,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 3352,
          "y" : 849
        },
        "to" : {
          "x" : 3349,
          "y" : 749
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 3348,
          "y" : 842
        },
        "b" : {
          "x" : 3352,
          "y" : 849
        },
        "c" : {
          "x" : 3356,
          "y" : 842
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 3356,
          "y" : 842
        }
      }
    }, {
      "edgeId" : 38562,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 3345,
          "y" : 849
        },
        "to" : {
          "x" : 3311,
          "y" : 781
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 3338,
          "y" : 845
        },
        "b" : {
          "x" : 3345,
          "y" : 849
        },
        "c" : {
          "x" : 3345,
          "y" : 841
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 3345,
          "y" : 841
        }
      }
    } ]
  }, {
    "id" : 38536,
    "reactomeId" : 9997580,
    "displayName" : "p21 RAS:GTP",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 3445,
      "y" : 783
    },
    "minX" : 3294,
    "maxX" : 3492,
    "minY" : 749,
    "maxY" : 817,
    "prop" : {
      "x" : 3405,
      "y" : 763,
      "width" : 81,
      "height" : 41
    },
    "textPosition" : {
      "x" : 3413,
      "y" : 769
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 3486,
          "y" : 763
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 3486,
          "y" : 763
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 38532,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 3402,
          "y" : 792
        },
        "to" : {
          "x" : 3294,
          "y" : 817
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 3396,
          "y" : 797
        },
        "b" : {
          "x" : 3402,
          "y" : 792
        },
        "c" : {
          "x" : 3394,
          "y" : 790
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 3394,
          "y" : 790
        }
      }
    }, {
      "edgeId" : 38600,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 3402,
          "y" : 768
        },
        "to" : {
          "x" : 3349,
          "y" : 749
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 3394,
          "y" : 769
        },
        "b" : {
          "x" : 3402,
          "y" : 768
        },
        "c" : {
          "x" : 3397,
          "y" : 762
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 3397,
          "y" : 762
        }
      }
    }, {
      "edgeId" : 38562,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 3402,
          "y" : 782
        },
        "to" : {
          "x" : 3311,
          "y" : 781
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 3395,
          "y" : 786
        },
        "b" : {
          "x" : 3402,
          "y" : 782
        },
        "c" : {
          "x" : 3395,
          "y" : 778
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 3395,
          "y" : 778
        }
      }
    } ]
  }, {
    "id" : 38538,
    "reactomeId" : 10058107,
    "displayName" : "Activated FGFR1:p-FRS:PTPN11",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 3469,
      "y" : 399
    },
    "minX" : 3406,
    "maxX" : 3584,
    "minY" : 334,
    "maxY" : 424,
    "prop" : {
      "x" : 3406,
      "y" : 374,
      "width" : 127,
      "height" : 50
    },
    "textPosition" : {
      "x" : 3407,
      "y" : 389
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 3533,
          "y" : 374
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 3533,
          "y" : 374
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 38537,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 38539,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 3536,
          "y" : 396
        },
        "to" : {
          "x" : 3560,
          "y" : 395
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 38539,
      "type" : "CATALYST",
      "segments" : [ {
        "from" : {
          "x" : 3502,
          "y" : 371
        },
        "to" : {
          "x" : 3555,
          "y" : 334
        }
      }, {
        "from" : {
          "x" : 3555,
          "y" : 334
        },
        "to" : {
          "x" : 3578,
          "y" : 382
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 3580,
          "y" : 385
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 3580,
          "y" : 385
        }
      }
    } ]
  }, {
    "id" : 38540,
    "reactomeId" : 113592,
    "displayName" : "ATP",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 3546,
      "y" : 470
    },
    "minX" : 3526,
    "maxX" : 3567,
    "minY" : 395,
    "maxY" : 485,
    "prop" : {
      "x" : 3526,
      "y" : 455,
      "width" : 40,
      "height" : 30
    },
    "textPosition" : {
      "x" : 3530,
      "y" : 459
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 3561,
          "y" : 460
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 3561,
          "y" : 460
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 38539,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 3548,
          "y" : 452
        },
        "to" : {
          "x" : 3560,
          "y" : 395
        }
      } ],
      "stoichiometry" : {
        "value" : 2,
        "shape" : {
          "a" : {
            "x" : 3548,
            "y" : 417
          },
          "b" : {
            "x" : 3560,
            "y" : 429
          },
          "type" : "BOX",
          "empty" : true,
          "centre" : {
            "x" : 3554,
            "y" : 423
          }
        }
      }
    } ]
  }, {
    "id" : 38541,
    "reactomeId" : 29370,
    "displayName" : "ADP",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 3643,
      "y" : 445
    },
    "minX" : 3613,
    "maxX" : 3665,
    "minY" : 396,
    "maxY" : 460,
    "prop" : {
      "x" : 3623,
      "y" : 430,
      "width" : 41,
      "height" : 30
    },
    "textPosition" : {
      "x" : 3627,
      "y" : 434
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 3659,
          "y" : 435
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 3659,
          "y" : 435
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 38539,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 3633,
          "y" : 427
        },
        "to" : {
          "x" : 3613,
          "y" : 396
        }
      } ],
      "stoichiometry" : {
        "value" : 2,
        "shape" : {
          "a" : {
            "x" : 3617,
            "y" : 405
          },
          "b" : {
            "x" : 3629,
            "y" : 417
          },
          "type" : "BOX",
          "empty" : true,
          "centre" : {
            "x" : 3623,
            "y" : 411
          }
        }
      },
      "endShape" : {
        "a" : {
          "x" : 3626,
          "y" : 423
        },
        "b" : {
          "x" : 3633,
          "y" : 427
        },
        "c" : {
          "x" : 3633,
          "y" : 419
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 3633,
          "y" : 419
        }
      }
    } ]
  }, {
    "id" : 38542,
    "reactomeId" : 10058113,
    "displayName" : "Activated FGFR1:p-FRS:p-PTPN11",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 3738,
      "y" : 397
    },
    "minX" : 3307,
    "maxX" : 3803,
    "minY" : 373,
    "maxY" : 743,
    "prop" : {
      "x" : 3680,
      "y" : 379,
      "width" : 117,
      "height" : 37
    },
    "textPosition" : {
      "x" : 3682,
      "y" : 381
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 3797,
          "y" : 379
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 3797,
          "y" : 379
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 38600,
      "type" : "ACTIVATOR",
      "segments" : [ {
        "from" : {
          "x" : 3714,
          "y" : 419
        },
        "to" : {
          "x" : 3307,
          "y" : 743
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 3310,
          "y" : 736
        },
        "b" : {
          "x" : 3307,
          "y" : 743
        },
        "c" : {
          "x" : 3315,
          "y" : 742
        },
        "type" : "ARROW",
        "empty" : true,
        "centre" : {
          "x" : 3315,
          "y" : 742
        }
      }
    }, {
      "edgeId" : 38539,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 3677,
          "y" : 396
        },
        "to" : {
          "x" : 3613,
          "y" : 396
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 3670,
          "y" : 400
        },
        "b" : {
          "x" : 3677,
          "y" : 396
        },
        "c" : {
          "x" : 3670,
          "y" : 392
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 3670,
          "y" : 392
        }
      }
    } ]
  }, {
    "id" : 38544,
    "reactomeId" : 10000138,
    "displayName" : "PLCG1",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 1861,
      "y" : 370
    },
    "minX" : 1811,
    "maxX" : 1966,
    "minY" : 343,
    "maxY" : 389,
    "prop" : {
      "x" : 1811,
      "y" : 351,
      "width" : 100,
      "height" : 38
    },
    "textPosition" : {
      "x" : 1837,
      "y" : 359
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1911,
          "y" : 351
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1911,
          "y" : 351
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 38543,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1914,
          "y" : 357
        },
        "to" : {
          "x" : 1966,
          "y" : 343
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 38545,
    "reactomeId" : 179838,
    "displayName" : "PI(3,4,5)P3",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 2026,
      "y" : 315
    },
    "minX" : 1966,
    "maxX" : 2066,
    "minY" : 292,
    "maxY" : 343,
    "prop" : {
      "x" : 1988,
      "y" : 293,
      "width" : 77,
      "height" : 44
    },
    "textPosition" : {
      "x" : 1988,
      "y" : 304
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 2060,
          "y" : 298
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 2060,
          "y" : 298
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 38543,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1985,
          "y" : 332
        },
        "to" : {
          "x" : 1966,
          "y" : 343
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 38546,
    "reactomeId" : 10057899,
    "displayName" : "activated FGFR1:PLCG1",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 1905,
      "y" : 240
    },
    "minX" : 1773,
    "maxX" : 1974,
    "minY" : 210,
    "maxY" : 279,
    "prop" : {
      "x" : 1842,
      "y" : 216,
      "width" : 126,
      "height" : 49
    },
    "textPosition" : {
      "x" : 1848,
      "y" : 230
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1968,
          "y" : 216
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1968,
          "y" : 216
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 38543,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 38547,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1839,
          "y" : 241
        },
        "to" : {
          "x" : 1793,
          "y" : 243
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 38547,
      "type" : "CATALYST",
      "segments" : [ {
        "from" : {
          "x" : 1844,
          "y" : 268
        },
        "to" : {
          "x" : 1809,
          "y" : 279
        }
      }, {
        "from" : {
          "x" : 1809,
          "y" : 279
        },
        "to" : {
          "x" : 1780,
          "y" : 254
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 1777,
          "y" : 251
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1777,
          "y" : 251
        }
      }
    } ]
  }, {
    "id" : 38548,
    "reactomeId" : 113592,
    "displayName" : "ATP",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 1822,
      "y" : 201
    },
    "minX" : 1793,
    "maxX" : 1850,
    "minY" : 186,
    "maxY" : 243,
    "prop" : {
      "x" : 1796,
      "y" : 187,
      "width" : 53,
      "height" : 29
    },
    "textPosition" : {
      "x" : 1807,
      "y" : 191
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1844,
          "y" : 192
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1844,
          "y" : 192
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 38547,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1811,
          "y" : 219
        },
        "to" : {
          "x" : 1793,
          "y" : 243
        }
      } ],
      "stoichiometry" : {
        "value" : 4,
        "shape" : {
          "a" : {
            "x" : 1796,
            "y" : 225
          },
          "b" : {
            "x" : 1808,
            "y" : 237
          },
          "type" : "BOX",
          "empty" : true,
          "centre" : {
            "x" : 1802,
            "y" : 231
          }
        }
      }
    } ]
  }, {
    "id" : 38549,
    "reactomeId" : 10057901,
    "displayName" : "activated FGFR1:p-4Y-PLCG1",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 1637,
      "y" : 249
    },
    "minX" : 1581,
    "maxX" : 1730,
    "minY" : 214,
    "maxY" : 278,
    "prop" : {
      "x" : 1581,
      "y" : 220,
      "width" : 112,
      "height" : 58
    },
    "textPosition" : {
      "x" : 1596,
      "y" : 229
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1693,
          "y" : 220
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1693,
          "y" : 220
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 38547,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 1696,
          "y" : 246
        },
        "to" : {
          "x" : 1730,
          "y" : 245
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 1703,
          "y" : 242
        },
        "b" : {
          "x" : 1696,
          "y" : 246
        },
        "c" : {
          "x" : 1703,
          "y" : 250
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 1703,
          "y" : 250
        }
      }
    }, {
      "edgeId" : 38551,
      "type" : "INPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 38550,
    "reactomeId" : 29370,
    "displayName" : "ADP",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 1712,
      "y" : 196
    },
    "minX" : 1681,
    "maxX" : 1744,
    "minY" : 183,
    "maxY" : 245,
    "prop" : {
      "x" : 1681,
      "y" : 184,
      "width" : 62,
      "height" : 25
    },
    "textPosition" : {
      "x" : 1695,
      "y" : 186
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1738,
          "y" : 189
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1738,
          "y" : 189
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 38547,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 1716,
          "y" : 212
        },
        "to" : {
          "x" : 1730,
          "y" : 245
        }
      } ],
      "stoichiometry" : {
        "value" : 4,
        "shape" : {
          "a" : {
            "x" : 1717,
            "y" : 222
          },
          "b" : {
            "x" : 1729,
            "y" : 234
          },
          "type" : "BOX",
          "empty" : true,
          "centre" : {
            "x" : 1723,
            "y" : 228
          }
        }
      },
      "endShape" : {
        "a" : {
          "x" : 1722,
          "y" : 217
        },
        "b" : {
          "x" : 1716,
          "y" : 212
        },
        "c" : {
          "x" : 1715,
          "y" : 220
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 1715,
          "y" : 220
        }
      }
    } ]
  }, {
    "id" : 38552,
    "reactomeId" : 10004456,
    "displayName" : "phospho-p-4Y-PLCG1",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 1399,
      "y" : 189
    },
    "minX" : 1349,
    "maxX" : 1499,
    "minY" : 141,
    "maxY" : 216,
    "prop" : {
      "x" : 1349,
      "y" : 163,
      "width" : 100,
      "height" : 53
    },
    "textPosition" : {
      "x" : 1350,
      "y" : 172
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1449,
          "y" : 163
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1449,
          "y" : 163
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 38551,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 1452,
          "y" : 165
        },
        "to" : {
          "x" : 1499,
          "y" : 141
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 1456,
          "y" : 158
        },
        "b" : {
          "x" : 1452,
          "y" : 165
        },
        "c" : {
          "x" : 1460,
          "y" : 165
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 1460,
          "y" : 165
        }
      }
    } ]
  }, {
    "id" : 38554,
    "reactomeId" : 10057983,
    "displayName" : "Shc1",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 2249,
      "y" : 660
    },
    "minX" : 2213,
    "maxX" : 2292,
    "minY" : 478,
    "maxY" : 683,
    "prop" : {
      "x" : 2213,
      "y" : 638,
      "width" : 73,
      "height" : 45
    },
    "textPosition" : {
      "x" : 2230,
      "y" : 650
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 2286,
          "y" : 638
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 2286,
          "y" : 638
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 38553,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 2249,
          "y" : 632
        },
        "to" : {
          "x" : 2249,
          "y" : 478
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 38555,
    "reactomeId" : 10058092,
    "displayName" : "Activated FGFR1:SHC1",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 2314,
      "y" : 557
    },
    "minX" : 2261,
    "maxX" : 2415,
    "minY" : 522,
    "maxY" : 581,
    "prop" : {
      "x" : 2261,
      "y" : 533,
      "width" : 107,
      "height" : 48
    },
    "textPosition" : {
      "x" : 2272,
      "y" : 546
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 2368,
          "y" : 533
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 2368,
          "y" : 533
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 38553,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 38556,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 2371,
          "y" : 557
        },
        "to" : {
          "x" : 2392,
          "y" : 558
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 38556,
      "type" : "CATALYST",
      "segments" : [ {
        "from" : {
          "x" : 2371,
          "y" : 534
        },
        "to" : {
          "x" : 2396,
          "y" : 522
        }
      }, {
        "from" : {
          "x" : 2396,
          "y" : 522
        },
        "to" : {
          "x" : 2409,
          "y" : 544
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 2411,
          "y" : 548
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 2411,
          "y" : 548
        }
      }
    } ]
  }, {
    "id" : 38557,
    "reactomeId" : 113592,
    "displayName" : "ATP",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 2367,
      "y" : 627
    },
    "minX" : 2338,
    "maxX" : 2398,
    "minY" : 558,
    "maxY" : 641,
    "prop" : {
      "x" : 2338,
      "y" : 613,
      "width" : 59,
      "height" : 28
    },
    "textPosition" : {
      "x" : 2352,
      "y" : 616
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 2392,
          "y" : 618
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 2392,
          "y" : 618
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 38556,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 2372,
          "y" : 610
        },
        "to" : {
          "x" : 2392,
          "y" : 558
        }
      } ],
      "stoichiometry" : {
        "value" : 3,
        "shape" : {
          "a" : {
            "x" : 2376,
            "y" : 578
          },
          "b" : {
            "x" : 2388,
            "y" : 590
          },
          "type" : "BOX",
          "empty" : true,
          "centre" : {
            "x" : 2382,
            "y" : 584
          }
        }
      }
    } ]
  }, {
    "id" : 38558,
    "reactomeId" : 10058102,
    "displayName" : "Activated FGFR1:p-SHC1",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 2531,
      "y" : 555
    },
    "minX" : 2440,
    "maxX" : 2989,
    "minY" : 521,
    "maxY" : 706,
    "prop" : {
      "x" : 2471,
      "y" : 527,
      "width" : 120,
      "height" : 56
    },
    "textPosition" : {
      "x" : 2474,
      "y" : 548
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 2591,
          "y" : 527
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 2591,
          "y" : 527
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 38556,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 2468,
          "y" : 556
        },
        "to" : {
          "x" : 2440,
          "y" : 558
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 2461,
          "y" : 560
        },
        "b" : {
          "x" : 2468,
          "y" : 556
        },
        "c" : {
          "x" : 2461,
          "y" : 553
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 2461,
          "y" : 553
        }
      }
    }, {
      "edgeId" : 38560,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 2547,
          "y" : 586
        },
        "to" : {
          "x" : 2613,
          "y" : 698
        }
      }, {
        "from" : {
          "x" : 2613,
          "y" : 698
        },
        "to" : {
          "x" : 2989,
          "y" : 706
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 38559,
    "reactomeId" : 29370,
    "displayName" : "ADP",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 2475,
      "y" : 624
    },
    "minX" : 2440,
    "maxX" : 2506,
    "minY" : 558,
    "maxY" : 637,
    "prop" : {
      "x" : 2446,
      "y" : 611,
      "width" : 59,
      "height" : 26
    },
    "textPosition" : {
      "x" : 2459,
      "y" : 613
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 2500,
          "y" : 616
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 2500,
          "y" : 616
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 38556,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 2468,
          "y" : 608
        },
        "to" : {
          "x" : 2440,
          "y" : 558
        }
      } ],
      "stoichiometry" : {
        "value" : 3,
        "shape" : {
          "a" : {
            "x" : 2448,
            "y" : 577
          },
          "b" : {
            "x" : 2460,
            "y" : 589
          },
          "type" : "BOX",
          "empty" : true,
          "centre" : {
            "x" : 2454,
            "y" : 583
          }
        }
      },
      "endShape" : {
        "a" : {
          "x" : 2461,
          "y" : 604
        },
        "b" : {
          "x" : 2468,
          "y" : 608
        },
        "c" : {
          "x" : 2468,
          "y" : 600
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 2468,
          "y" : 600
        }
      }
    } ]
  }, {
    "id" : 38561,
    "reactomeId" : 10058126,
    "displayName" : "Activated FGFR1:p-SHC1:GRB2:SOS1",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 3130,
      "y" : 554
    },
    "minX" : 3071,
    "maxX" : 3230,
    "minY" : 523,
    "maxY" : 773,
    "prop" : {
      "x" : 3071,
      "y" : 529,
      "width" : 119,
      "height" : 50
    },
    "textPosition" : {
      "x" : 3074,
      "y" : 530
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 3190,
          "y" : 529
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 3190,
          "y" : 529
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 38560,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 38562,
      "type" : "CATALYST",
      "segments" : [ {
        "from" : {
          "x" : 3141,
          "y" : 582
        },
        "to" : {
          "x" : 3224,
          "y" : 765
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 3226,
          "y" : 769
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 3226,
          "y" : 769
        }
      }
    } ]
  }, {
    "id" : 38564,
    "reactomeId" : 10044116,
    "displayName" : "Activated FGFR1:p-FRS2:GRB2:GAB1:PIK3R1",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 4119,
      "y" : 406
    },
    "minX" : 4052,
    "maxX" : 4254,
    "minY" : 368,
    "maxY" : 439,
    "prop" : {
      "x" : 4052,
      "y" : 374,
      "width" : 134,
      "height" : 65
    },
    "textPosition" : {
      "x" : 4056,
      "y" : 390
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 4186,
          "y" : 374
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 4186,
          "y" : 374
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 38563,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 38565,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 4189,
          "y" : 406
        },
        "to" : {
          "x" : 4254,
          "y" : 408
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 38566,
    "reactomeId" : 9027214,
    "displayName" : "Pik3ca",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 4255,
      "y" : 643
    },
    "minX" : 4200,
    "maxX" : 4316,
    "minY" : 408,
    "maxY" : 661,
    "prop" : {
      "x" : 4200,
      "y" : 626,
      "width" : 110,
      "height" : 35
    },
    "textPosition" : {
      "x" : 4230,
      "y" : 633
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 4310,
          "y" : 626
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 4310,
          "y" : 626
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 38565,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 4254,
          "y" : 623
        },
        "to" : {
          "x" : 4254,
          "y" : 408
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 38578,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 4258,
          "y" : 623
        },
        "to" : {
          "x" : 4278,
          "y" : 516
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 38567,
    "reactomeId" : 10044118,
    "displayName" : "Activated FGFR1:p-FRS2:GRB2:GAB1:PI3K",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 4392,
      "y" : 407
    },
    "minX" : 4337,
    "maxX" : 4656,
    "minY" : 363,
    "maxY" : 460,
    "prop" : {
      "x" : 4337,
      "y" : 369,
      "width" : 110,
      "height" : 76
    },
    "textPosition" : {
      "x" : 4338,
      "y" : 396
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 4447,
          "y" : 369
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 4447,
          "y" : 369
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 38565,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 38568,
      "type" : "CATALYST",
      "segments" : [ {
        "from" : {
          "x" : 4450,
          "y" : 400
        },
        "to" : {
          "x" : 4635,
          "y" : 378
        }
      }, {
        "from" : {
          "x" : 4635,
          "y" : 378
        },
        "to" : {
          "x" : 4651,
          "y" : 452
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 4652,
          "y" : 456
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 4652,
          "y" : 456
        }
      }
    } ]
  }, {
    "id" : 38569,
    "reactomeId" : 179856,
    "displayName" : "PI(4,5)P2",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 4500,
      "y" : 506
    },
    "minX" : 4464,
    "maxX" : 4639,
    "minY" : 468,
    "maxY" : 521,
    "prop" : {
      "x" : 4464,
      "y" : 492,
      "width" : 72,
      "height" : 29
    },
    "textPosition" : {
      "x" : 4467,
      "y" : 496
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 4531,
          "y" : 497
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 4531,
          "y" : 497
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 38568,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 4539,
          "y" : 495
        },
        "to" : {
          "x" : 4628,
          "y" : 468
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 38573,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 4539,
          "y" : 508
        },
        "to" : {
          "x" : 4639,
          "y" : 517
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 38570,
    "reactomeId" : 113592,
    "displayName" : "ATP",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 4462,
      "y" : 607
    },
    "minX" : 4433,
    "maxX" : 4639,
    "minY" : 468,
    "maxY" : 618,
    "prop" : {
      "x" : 4433,
      "y" : 596,
      "width" : 58,
      "height" : 22
    },
    "textPosition" : {
      "x" : 4446,
      "y" : 596
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 4486,
          "y" : 601
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 4486,
          "y" : 601
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 38568,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 4475,
          "y" : 593
        },
        "to" : {
          "x" : 4628,
          "y" : 468
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 38573,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 4483,
          "y" : 593
        },
        "to" : {
          "x" : 4639,
          "y" : 517
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 38571,
    "reactomeId" : 29370,
    "displayName" : "ADP",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 4775,
      "y" : 613
    },
    "minX" : 4682,
    "maxX" : 4807,
    "minY" : 467,
    "maxY" : 628,
    "prop" : {
      "x" : 4745,
      "y" : 598,
      "width" : 61,
      "height" : 30
    },
    "textPosition" : {
      "x" : 4759,
      "y" : 602
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 4801,
          "y" : 603
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 4801,
          "y" : 603
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 38568,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 4765,
          "y" : 595
        },
        "to" : {
          "x" : 4682,
          "y" : 467
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 4758,
          "y" : 591
        },
        "b" : {
          "x" : 4765,
          "y" : 595
        },
        "c" : {
          "x" : 4765,
          "y" : 587
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 4765,
          "y" : 587
        }
      }
    }, {
      "edgeId" : 38573,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 4761,
          "y" : 595
        },
        "to" : {
          "x" : 4688,
          "y" : 517
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 4753,
          "y" : 593
        },
        "b" : {
          "x" : 4761,
          "y" : 595
        },
        "c" : {
          "x" : 4759,
          "y" : 587
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 4759,
          "y" : 587
        }
      }
    } ]
  }, {
    "id" : 38572,
    "reactomeId" : 179838,
    "displayName" : "PI(3,4,5)P3",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 4787,
      "y" : 512
    },
    "minX" : 4682,
    "maxX" : 4825,
    "minY" : 467,
    "maxY" : 527,
    "prop" : {
      "x" : 4750,
      "y" : 498,
      "width" : 74,
      "height" : 29
    },
    "textPosition" : {
      "x" : 4756,
      "y" : 495
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 4819,
          "y" : 503
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 4819,
          "y" : 503
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 38568,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 4753,
          "y" : 495
        },
        "to" : {
          "x" : 4682,
          "y" : 467
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 4745,
          "y" : 496
        },
        "b" : {
          "x" : 4753,
          "y" : 495
        },
        "c" : {
          "x" : 4748,
          "y" : 489
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 4748,
          "y" : 489
        }
      }
    }, {
      "edgeId" : 38573,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 4747,
          "y" : 513
        },
        "to" : {
          "x" : 4688,
          "y" : 517
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 4740,
          "y" : 517
        },
        "b" : {
          "x" : 4747,
          "y" : 513
        },
        "c" : {
          "x" : 4740,
          "y" : 509
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 4740,
          "y" : 509
        }
      }
    } ]
  }, {
    "id" : 38574,
    "reactomeId" : 10044148,
    "displayName" : "Activated FGFR1:p-FRS2:p-PTPN11:GRB2:GAB1:PI3K",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 4396,
      "y" : 519
    },
    "minX" : 4335,
    "maxX" : 4653,
    "minY" : 432,
    "maxY" : 554,
    "prop" : {
      "x" : 4335,
      "y" : 485,
      "width" : 122,
      "height" : 69
    },
    "textPosition" : {
      "x" : 4336,
      "y" : 505
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 4457,
          "y" : 485
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 4457,
          "y" : 485
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 38573,
      "type" : "CATALYST",
      "segments" : [ {
        "from" : {
          "x" : 4454,
          "y" : 482
        },
        "to" : {
          "x" : 4543,
          "y" : 432
        }
      }, {
        "from" : {
          "x" : 4543,
          "y" : 432
        },
        "to" : {
          "x" : 4646,
          "y" : 509
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 4649,
          "y" : 512
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 4649,
          "y" : 512
        }
      }
    }, {
      "edgeId" : 38578,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 38576,
    "reactomeId" : 10044144,
    "displayName" : "Activated FGFR1:p-FRS2:p-PTPN11",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 3831,
      "y" : 493
    },
    "minX" : 3763,
    "maxX" : 5032,
    "minY" : 294,
    "maxY" : 526,
    "prop" : {
      "x" : 3763,
      "y" : 460,
      "width" : 136,
      "height" : 66
    },
    "textPosition" : {
      "x" : 3768,
      "y" : 491
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 3899,
          "y" : 460
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 3899,
          "y" : 460
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 38575,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 3902,
          "y" : 498
        },
        "to" : {
          "x" : 3980,
          "y" : 504
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 38583,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 3846,
          "y" : 457
        },
        "to" : {
          "x" : 3927,
          "y" : 294
        }
      }, {
        "from" : {
          "x" : 3927,
          "y" : 294
        },
        "to" : {
          "x" : 4890,
          "y" : 297
        }
      }, {
        "from" : {
          "x" : 4890,
          "y" : 297
        },
        "to" : {
          "x" : 5032,
          "y" : 518
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 38577,
    "reactomeId" : 10044146,
    "displayName" : "Activated FGFR:p-FRS2:p-PTPN11:GRB2:GAB1:PIK3R1",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 4123,
      "y" : 517
    },
    "minX" : 4065,
    "maxX" : 4278,
    "minY" : 478,
    "maxY" : 550,
    "prop" : {
      "x" : 4065,
      "y" : 484,
      "width" : 116,
      "height" : 66
    },
    "textPosition" : {
      "x" : 4070,
      "y" : 487
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 4181,
          "y" : 484
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 4181,
          "y" : 484
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 38575,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 38578,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 4184,
          "y" : 516
        },
        "to" : {
          "x" : 4278,
          "y" : 516
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 38580,
    "reactomeId" : 113592,
    "displayName" : "ATP",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 2614,
      "y" : 624
    },
    "minX" : 2585,
    "maxX" : 2644,
    "minY" : 543,
    "maxY" : 638,
    "prop" : {
      "x" : 2585,
      "y" : 611,
      "width" : 58,
      "height" : 27
    },
    "textPosition" : {
      "x" : 2598,
      "y" : 614
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 2638,
          "y" : 616
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 2638,
          "y" : 616
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 38579,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 2618,
          "y" : 608
        },
        "to" : {
          "x" : 2642,
          "y" : 543
        }
      } ],
      "stoichiometry" : {
        "value" : 8,
        "shape" : {
          "a" : {
            "x" : 2624,
            "y" : 569
          },
          "b" : {
            "x" : 2636,
            "y" : 581
          },
          "type" : "BOX",
          "empty" : true,
          "centre" : {
            "x" : 2630,
            "y" : 575
          }
        }
      }
    } ]
  }, {
    "id" : 38581,
    "reactomeId" : 10058073,
    "displayName" : "Activated FGFR1:p-8T-FRS2",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 2813,
      "y" : 568
    },
    "minX" : 2719,
    "maxX" : 2878,
    "minY" : 535,
    "maxY" : 595,
    "prop" : {
      "x" : 2755,
      "y" : 541,
      "width" : 117,
      "height" : 54
    },
    "textPosition" : {
      "x" : 2757,
      "y" : 560
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 2872,
          "y" : 541
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 2872,
          "y" : 541
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 38579,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 2752,
          "y" : 552
        },
        "to" : {
          "x" : 2719,
          "y" : 543
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 2744,
          "y" : 554
        },
        "b" : {
          "x" : 2752,
          "y" : 552
        },
        "c" : {
          "x" : 2746,
          "y" : 546
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 2746,
          "y" : 546
        }
      }
    } ]
  }, {
    "id" : 38582,
    "reactomeId" : 29370,
    "displayName" : "ADP",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 2749,
      "y" : 637
    },
    "minX" : 2716,
    "maxX" : 2784,
    "minY" : 543,
    "maxY" : 650,
    "prop" : {
      "x" : 2716,
      "y" : 624,
      "width" : 67,
      "height" : 26
    },
    "textPosition" : {
      "x" : 2733,
      "y" : 626
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 2778,
          "y" : 629
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 2778,
          "y" : 629
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 38579,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 2744,
          "y" : 621
        },
        "to" : {
          "x" : 2719,
          "y" : 543
        }
      } ],
      "stoichiometry" : {
        "value" : 8,
        "shape" : {
          "a" : {
            "x" : 2725,
            "y" : 576
          },
          "b" : {
            "x" : 2737,
            "y" : 588
          },
          "type" : "BOX",
          "empty" : true,
          "centre" : {
            "x" : 2731,
            "y" : 582
          }
        }
      },
      "endShape" : {
        "a" : {
          "x" : 2738,
          "y" : 616
        },
        "b" : {
          "x" : 2744,
          "y" : 621
        },
        "c" : {
          "x" : 2746,
          "y" : 613
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 2746,
          "y" : 613
        }
      }
    } ]
  }, {
    "id" : 38584,
    "reactomeId" : 10000013,
    "displayName" : "p-Y371-CBL:GRB2",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 4907,
      "y" : 627
    },
    "minX" : 4852,
    "maxX" : 5032,
    "minY" : 518,
    "maxY" : 646,
    "prop" : {
      "x" : 4852,
      "y" : 608,
      "width" : 111,
      "height" : 38
    },
    "textPosition" : {
      "x" : 4867,
      "y" : 611
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 4963,
          "y" : 608
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 4963,
          "y" : 608
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 38583,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 4928,
          "y" : 605
        },
        "to" : {
          "x" : 5032,
          "y" : 518
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 38585,
    "reactomeId" : 10058249,
    "displayName" : "Activated FGFR1:p-FRS2:p-PTPN11:p-CBL:GRB2",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 5181,
      "y" : 504
    },
    "minX" : 5098,
    "maxX" : 5334,
    "minY" : 468,
    "maxY" : 533,
    "prop" : {
      "x" : 5098,
      "y" : 475,
      "width" : 166,
      "height" : 58
    },
    "textPosition" : {
      "x" : 5101,
      "y" : 498
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 5264,
          "y" : 475
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 5264,
          "y" : 475
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 38583,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 38586,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 5267,
          "y" : 507
        },
        "to" : {
          "x" : 5304,
          "y" : 509
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 38586,
      "type" : "CATALYST",
      "segments" : [ {
        "from" : {
          "x" : 5267,
          "y" : 480
        },
        "to" : {
          "x" : 5307,
          "y" : 468
        }
      }, {
        "from" : {
          "x" : 5307,
          "y" : 468
        },
        "to" : {
          "x" : 5328,
          "y" : 497
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 5330,
          "y" : 500
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 5330,
          "y" : 500
        }
      }
    } ]
  }, {
    "id" : 38587,
    "reactomeId" : 9985374,
    "displayName" : "Ub",
    "schemaClass" : "DefinedSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 5280,
      "y" : 631
    },
    "minX" : 5251,
    "maxX" : 5309,
    "minY" : 509,
    "maxY" : 642,
    "prop" : {
      "x" : 5251,
      "y" : 621,
      "width" : 58,
      "height" : 21
    },
    "textPosition" : {
      "x" : 5267,
      "y" : 621
    },
    "connectors" : [ {
      "edgeId" : 38586,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 5282,
          "y" : 615
        },
        "to" : {
          "x" : 5304,
          "y" : 509
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 38588,
    "reactomeId" : 10058251,
    "displayName" : "Ub-Activated FGFR1 complex:Ub-p-FRS2",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 5445,
      "y" : 512
    },
    "minX" : 5381,
    "maxX" : 5515,
    "minY" : 475,
    "maxY" : 543,
    "prop" : {
      "x" : 5381,
      "y" : 481,
      "width" : 128,
      "height" : 62
    },
    "textPosition" : {
      "x" : 5381,
      "y" : 494
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 5509,
          "y" : 481
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 5509,
          "y" : 481
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 38586,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 38590,
    "reactomeId" : 10058045,
    "displayName" : "FGFRL1 dimer",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 275,
      "y" : 1918
    },
    "minX" : 223,
    "maxX" : 714,
    "minY" : 1890,
    "maxY" : 1998,
    "prop" : {
      "x" : 223,
      "y" : 1896,
      "width" : 104,
      "height" : 44
    },
    "textPosition" : {
      "x" : 229,
      "y" : 1919
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 327,
          "y" : 1896
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 327,
          "y" : 1896
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 38594,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 330,
          "y" : 1924
        },
        "to" : {
          "x" : 714,
          "y" : 1969
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 38589,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 274,
          "y" : 1943
        },
        "to" : {
          "x" : 274,
          "y" : 1998
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 38591,
    "reactomeId" : 10058065,
    "displayName" : "FGFRL1-binding FGFs",
    "schemaClass" : "CandidateSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 93,
      "y" : 1877
    },
    "minX" : 40,
    "maxX" : 274,
    "minY" : 1859,
    "maxY" : 1998,
    "prop" : {
      "x" : 40,
      "y" : 1859,
      "width" : 107,
      "height" : 36
    },
    "textPosition" : {
      "x" : 40,
      "y" : 1859
    },
    "connectors" : [ {
      "edgeId" : 38589,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 119,
          "y" : 1901
        },
        "to" : {
          "x" : 274,
          "y" : 1998
        }
      } ],
      "stoichiometry" : {
        "value" : 2,
        "shape" : {
          "a" : {
            "x" : 190,
            "y" : 1943
          },
          "b" : {
            "x" : 202,
            "y" : 1955
          },
          "type" : "BOX",
          "empty" : true,
          "centre" : {
            "x" : 196,
            "y" : 1949
          }
        }
      }
    } ]
  }, {
    "id" : 38592,
    "reactomeId" : 190915,
    "displayName" : "HS",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 95,
      "y" : 1990
    },
    "minX" : 45,
    "maxX" : 274,
    "minY" : 1971,
    "maxY" : 2008,
    "prop" : {
      "x" : 45,
      "y" : 1972,
      "width" : 101,
      "height" : 36
    },
    "textPosition" : {
      "x" : 83,
      "y" : 1979
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 141,
          "y" : 1977
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 141,
          "y" : 1977
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 38589,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 149,
          "y" : 1992
        },
        "to" : {
          "x" : 274,
          "y" : 1998
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 38593,
    "reactomeId" : 10058067,
    "displayName" : "FGFRL1-binding FGFs:FGFRL1 dimer",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 276,
      "y" : 2127
    },
    "minX" : 213,
    "maxX" : 346,
    "minY" : 2097,
    "maxY" : 2152,
    "prop" : {
      "x" : 213,
      "y" : 2103,
      "width" : 127,
      "height" : 49
    },
    "textPosition" : {
      "x" : 213,
      "y" : 2117
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 340,
          "y" : 2103
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 340,
          "y" : 2103
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 38589,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 38595,
    "reactomeId" : 10058059,
    "displayName" : "SPRED1/2 dimer",
    "schemaClass" : "DefinedSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 1257,
      "y" : 2039
    },
    "minX" : 714,
    "maxX" : 1319,
    "minY" : 1969,
    "maxY" : 2063,
    "prop" : {
      "x" : 1196,
      "y" : 2016,
      "width" : 123,
      "height" : 47
    },
    "textPosition" : {
      "x" : 1203,
      "y" : 2029
    },
    "connectors" : [ {
      "edgeId" : 38594,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1190,
          "y" : 2031
        },
        "to" : {
          "x" : 714,
          "y" : 1969
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 38596,
    "reactomeId" : 10058061,
    "displayName" : "FGFRL1 dimer:SPRED1/2 dimer",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 941,
      "y" : 2089
    },
    "minX" : 886,
    "maxX" : 1002,
    "minY" : 2062,
    "maxY" : 2111,
    "prop" : {
      "x" : 886,
      "y" : 2068,
      "width" : 110,
      "height" : 43
    },
    "textPosition" : {
      "x" : 887,
      "y" : 2076
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 996,
          "y" : 2068
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 996,
          "y" : 2068
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 38594,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 38598,
    "reactomeId" : 10058422,
    "displayName" : "FLRT1,2,3",
    "schemaClass" : "DefinedSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 2019,
      "y" : 591
    },
    "minX" : 1976,
    "maxX" : 2084,
    "minY" : 543,
    "maxY" : 609,
    "prop" : {
      "x" : 1976,
      "y" : 574,
      "width" : 86,
      "height" : 35
    },
    "textPosition" : {
      "x" : 1985,
      "y" : 581
    },
    "connectors" : [ {
      "edgeId" : 38597,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 2042,
          "y" : 568
        },
        "to" : {
          "x" : 2084,
          "y" : 543
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 38599,
    "reactomeId" : 10058424,
    "displayName" : "Activated FGFR1:FLRT",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 2179,
      "y" : 582
    },
    "minX" : 2126,
    "maxX" : 2239,
    "minY" : 558,
    "maxY" : 600,
    "prop" : {
      "x" : 2126,
      "y" : 564,
      "width" : 107,
      "height" : 36
    },
    "textPosition" : {
      "x" : 2140,
      "y" : 565
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 2233,
          "y" : 564
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 2233,
          "y" : 564
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 38597,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 38602,
    "reactomeId" : 10099027,
    "displayName" : "PIP3 activates AKT signaling",
    "schemaClass" : "Pathway",
    "renderableClass" : "EncapsulatedNode",
    "position" : {
      "x" : 4822,
      "y" : 424
    },
    "minX" : 4753,
    "maxX" : 4891,
    "minY" : 394,
    "maxY" : 455,
    "prop" : {
      "x" : 4753,
      "y" : 394,
      "width" : 138,
      "height" : 61
    },
    "textPosition" : {
      "x" : 4755,
      "y" : 403
    },
    "connectors" : [ ]
  }, {
    "id" : 38603,
    "reactomeId" : 10098953,
    "displayName" : "DAG and IP3 signaling",
    "schemaClass" : "Pathway",
    "renderableClass" : "EncapsulatedNode",
    "position" : {
      "x" : 1397,
      "y" : 83
    },
    "minX" : 1334,
    "maxX" : 1460,
    "minY" : 55,
    "maxY" : 112,
    "prop" : {
      "x" : 1334,
      "y" : 55,
      "width" : 126,
      "height" : 57
    },
    "textPosition" : {
      "x" : 1348,
      "y" : 62
    },
    "connectors" : [ ]
  }, {
    "id" : 38611,
    "reactomeId" : 10101263,
    "displayName" : "RAF/MAP kinase cascade",
    "schemaClass" : "Pathway",
    "renderableClass" : "EncapsulatedNode",
    "position" : {
      "x" : 3403,
      "y" : 935
    },
    "minX" : 3334,
    "maxX" : 3473,
    "minY" : 900,
    "maxY" : 970,
    "prop" : {
      "x" : 3334,
      "y" : 900,
      "width" : 139,
      "height" : 70
    },
    "textPosition" : {
      "x" : 3344,
      "y" : 913
    },
    "connectors" : [ ]
  } ],
  "edges" : [ {
    "id" : 38528,
    "reactomeId" : 10058111,
    "displayName" : "Activated FGFR1:p-FRS binds GRB2:SOS1",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 3017,
      "y" : 493
    },
    "minX" : 2974,
    "maxX" : 3066,
    "minY" : 487,
    "maxY" : 499,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 2974,
        "y" : 496
      },
      "to" : {
        "x" : 3017,
        "y" : 493
      }
    }, {
      "from" : {
        "x" : 3017,
        "y" : 493
      },
      "to" : {
        "x" : 3066,
        "y" : 490
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 3059,
        "y" : 494
      },
      "b" : {
        "x" : 3066,
        "y" : 490
      },
      "c" : {
        "x" : 3059,
        "y" : 486
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 3059,
        "y" : 486
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 3017,
        "y" : 493
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 3017,
        "y" : 493
      }
    },
    "inputs" : [ {
      "id" : 38529,
      "points" : [ {
        "x" : 2947,
        "y" : 604
      } ]
    }, {
      "id" : 38530,
      "points" : [ {
        "x" : 2928,
        "y" : 478
      } ]
    } ],
    "outputs" : [ {
      "id" : 38531
    } ]
  }, {
    "id" : 38594,
    "reactomeId" : 10058063,
    "displayName" : "FGFRL1 binds SPRED1/2",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 761,
      "y" : 2068
    },
    "minX" : 714,
    "maxX" : 883,
    "minY" : 1969,
    "maxY" : 2082,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 714,
        "y" : 1969
      },
      "to" : {
        "x" : 761,
        "y" : 2068
      }
    }, {
      "from" : {
        "x" : 761,
        "y" : 2068
      },
      "to" : {
        "x" : 883,
        "y" : 2082
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 876,
        "y" : 2085
      },
      "b" : {
        "x" : 883,
        "y" : 2082
      },
      "c" : {
        "x" : 877,
        "y" : 2077
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 877,
        "y" : 2077
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 761,
        "y" : 2068
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 761,
        "y" : 2068
      }
    },
    "inputs" : [ {
      "id" : 38590,
      "points" : [ {
        "x" : 330,
        "y" : 1924
      } ]
    }, {
      "id" : 38595,
      "points" : [ {
        "x" : 1190,
        "y" : 2031
      } ]
    } ],
    "outputs" : [ {
      "id" : 38596
    } ]
  }, {
    "id" : 38466,
    "reactomeId" : 10000691,
    "displayName" : "FGFR1c binds to Klotho-bound FGF23",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 286,
      "y" : 1629
    },
    "minX" : 280,
    "maxX" : 292,
    "minY" : 1587,
    "maxY" : 1658,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 282,
        "y" : 1587
      },
      "to" : {
        "x" : 286,
        "y" : 1629
      }
    }, {
      "from" : {
        "x" : 286,
        "y" : 1629
      },
      "to" : {
        "x" : 286,
        "y" : 1658
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 282,
        "y" : 1651
      },
      "b" : {
        "x" : 286,
        "y" : 1658
      },
      "c" : {
        "x" : 290,
        "y" : 1651
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 290,
        "y" : 1651
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 286,
        "y" : 1629
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 286,
        "y" : 1629
      }
    },
    "inputs" : [ {
      "id" : 38467,
      "points" : [ {
        "x" : 165,
        "y" : 1553
      } ],
      "stoichiometry" : 2
    }, {
      "id" : 38459,
      "points" : [ {
        "x" : 266,
        "y" : 902
      }, {
        "x" : 428,
        "y" : 1246
      }, {
        "x" : 432,
        "y" : 1502
      } ],
      "stoichiometry" : 2
    }, {
      "id" : 38468,
      "points" : [ {
        "x" : 143,
        "y" : 1611
      } ]
    } ],
    "outputs" : [ {
      "id" : 38469
    } ],
    "activators" : [ {
      "id" : 38468,
      "points" : [ {
        "x" : 143,
        "y" : 1622
      } ]
    } ]
  }, {
    "id" : 38532,
    "reactomeId" : 10057948,
    "displayName" : "Activated FGFR1:p-FRS:GRB2:SOS1 activates RAS nucleotide exchange",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 3249,
      "y" : 816
    },
    "minX" : 3218,
    "maxX" : 3294,
    "minY" : 810,
    "maxY" : 822,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 3218,
        "y" : 815
      },
      "to" : {
        "x" : 3249,
        "y" : 816
      }
    }, {
      "from" : {
        "x" : 3249,
        "y" : 816
      },
      "to" : {
        "x" : 3294,
        "y" : 817
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 3243,
        "y" : 810
      },
      "b" : {
        "x" : 3255,
        "y" : 822
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 3249,
        "y" : 816
      }
    },
    "inputs" : [ {
      "id" : 38533,
      "points" : [ {
        "x" : 3129,
        "y" : 794
      } ]
    }, {
      "id" : 38534,
      "points" : [ {
        "x" : 3124,
        "y" : 870
      } ]
    } ],
    "outputs" : [ {
      "id" : 38535,
      "points" : [ {
        "x" : 3335,
        "y" : 849
      } ]
    }, {
      "id" : 38536,
      "points" : [ {
        "x" : 3402,
        "y" : 792
      } ]
    } ],
    "catalysts" : [ {
      "id" : 38531,
      "points" : [ {
        "x" : 3182,
        "y" : 502
      }, {
        "x" : 3293,
        "y" : 534
      } ]
    } ]
  }, {
    "id" : 38597,
    "reactomeId" : 10058426,
    "displayName" : "Activated FGFR1 binds FLRT1,2,3",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 2100,
      "y" : 549
    },
    "minX" : 2084,
    "maxX" : 2135,
    "minY" : 543,
    "maxY" : 561,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 2084,
        "y" : 543
      },
      "to" : {
        "x" : 2100,
        "y" : 549
      }
    }, {
      "from" : {
        "x" : 2100,
        "y" : 549
      },
      "to" : {
        "x" : 2135,
        "y" : 561
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 2127,
        "y" : 563
      },
      "b" : {
        "x" : 2135,
        "y" : 561
      },
      "c" : {
        "x" : 2130,
        "y" : 555
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 2130,
        "y" : 555
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 2100,
        "y" : 549
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 2100,
        "y" : 549
      }
    },
    "inputs" : [ {
      "id" : 38517,
      "points" : [ {
        "x" : 2096,
        "y" : 431
      } ]
    }, {
      "id" : 38598,
      "points" : [ {
        "x" : 2042,
        "y" : 568
      } ]
    } ],
    "outputs" : [ {
      "id" : 38599
    } ]
  }, {
    "id" : 38470,
    "reactomeId" : 10000927,
    "displayName" : "Autocatalytic phosphorylation of Klotho-bound FGFR1c",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 291,
      "y" : 1755
    },
    "minX" : 285,
    "maxX" : 297,
    "minY" : 1736,
    "maxY" : 1774,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 290,
        "y" : 1736
      },
      "to" : {
        "x" : 291,
        "y" : 1755
      }
    }, {
      "from" : {
        "x" : 291,
        "y" : 1755
      },
      "to" : {
        "x" : 293,
        "y" : 1774
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 285,
        "y" : 1749
      },
      "b" : {
        "x" : 297,
        "y" : 1761
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 291,
        "y" : 1755
      }
    },
    "inputs" : [ {
      "id" : 38471,
      "points" : [ {
        "x" : 331,
        "y" : 1737
      } ],
      "stoichiometry" : 16
    }, {
      "id" : 38469,
      "points" : [ {
        "x" : 288,
        "y" : 1716
      } ]
    } ],
    "outputs" : [ {
      "id" : 38472,
      "points" : [ {
        "x" : 334,
        "y" : 1777
      } ],
      "stoichiometry" : 16
    }, {
      "id" : 38473,
      "points" : [ {
        "x" : 296,
        "y" : 1793
      } ]
    } ],
    "catalysts" : [ {
      "id" : 38469,
      "points" : [ {
        "x" : 271,
        "y" : 1716
      }, {
        "x" : 253,
        "y" : 1745
      } ]
    } ]
  }, {
    "id" : 38600,
    "reactomeId" : 10081822,
    "displayName" : "Activated FGFR1:p-FRS:p-PTPN11 activates RAS nucleotide exchange",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 3300,
      "y" : 749
    },
    "minX" : 3201,
    "maxX" : 3349,
    "minY" : 743,
    "maxY" : 755,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 3201,
        "y" : 749
      },
      "to" : {
        "x" : 3300,
        "y" : 749
      }
    }, {
      "from" : {
        "x" : 3300,
        "y" : 749
      },
      "to" : {
        "x" : 3349,
        "y" : 749
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 3294,
        "y" : 743
      },
      "b" : {
        "x" : 3306,
        "y" : 755
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 3300,
        "y" : 749
      }
    },
    "inputs" : [ {
      "id" : 38534,
      "points" : [ {
        "x" : 3111,
        "y" : 870
      } ]
    }, {
      "id" : 38533,
      "points" : [ {
        "x" : 3129,
        "y" : 773
      } ]
    } ],
    "outputs" : [ {
      "id" : 38535,
      "points" : [ {
        "x" : 3352,
        "y" : 849
      } ]
    }, {
      "id" : 38536,
      "points" : [ {
        "x" : 3402,
        "y" : 768
      } ]
    } ],
    "activators" : [ {
      "id" : 38542,
      "points" : [ {
        "x" : 3714,
        "y" : 419
      } ]
    } ]
  }, {
    "id" : 38537,
    "reactomeId" : 10058109,
    "displayName" : "Activated FGFR1:p-FRS bind to PPTN11",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 3349,
      "y" : 390
    },
    "minX" : 3325,
    "maxX" : 3403,
    "minY" : 384,
    "maxY" : 396,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 3325,
        "y" : 389
      },
      "to" : {
        "x" : 3349,
        "y" : 390
      }
    }, {
      "from" : {
        "x" : 3349,
        "y" : 390
      },
      "to" : {
        "x" : 3403,
        "y" : 394
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 3396,
        "y" : 397
      },
      "b" : {
        "x" : 3403,
        "y" : 394
      },
      "c" : {
        "x" : 3396,
        "y" : 389
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 3396,
        "y" : 389
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 3349,
        "y" : 390
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 3349,
        "y" : 390
      }
    },
    "inputs" : [ {
      "id" : 38514,
      "points" : [ {
        "x" : 3351,
        "y" : 612
      } ]
    }, {
      "id" : 38530,
      "points" : [ {
        "x" : 2923,
        "y" : 420
      }, {
        "x" : 2999,
        "y" : 382
      } ]
    } ],
    "outputs" : [ {
      "id" : 38538
    } ]
  }, {
    "id" : 38474,
    "reactomeId" : 9999754,
    "displayName" : "Binding of PIK3 regulatory alpha subunit to GRB2:GAB1",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 3970,
      "y" : 684
    },
    "minX" : 3964,
    "maxX" : 3977,
    "minY" : 648,
    "maxY" : 717,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 3977,
        "y" : 717
      },
      "to" : {
        "x" : 3970,
        "y" : 684
      }
    }, {
      "from" : {
        "x" : 3970,
        "y" : 684
      },
      "to" : {
        "x" : 3964,
        "y" : 648
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 3969,
        "y" : 654
      },
      "b" : {
        "x" : 3964,
        "y" : 648
      },
      "c" : {
        "x" : 3961,
        "y" : 655
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 3961,
        "y" : 655
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 3970,
        "y" : 684
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 3970,
        "y" : 684
      }
    },
    "inputs" : [ {
      "id" : 38475,
      "points" : [ {
        "x" : 3940,
        "y" : 734
      } ]
    }, {
      "id" : 38476,
      "points" : [ {
        "x" : 4029,
        "y" : 739
      } ]
    } ],
    "outputs" : [ {
      "id" : 38477
    } ]
  }, {
    "id" : 38539,
    "reactomeId" : 10058116,
    "displayName" : "Activated FGFR1:p-FRS phosphorylates PPTN11",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 3585,
      "y" : 396
    },
    "minX" : 3560,
    "maxX" : 3613,
    "minY" : 390,
    "maxY" : 402,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 3560,
        "y" : 395
      },
      "to" : {
        "x" : 3585,
        "y" : 396
      }
    }, {
      "from" : {
        "x" : 3585,
        "y" : 396
      },
      "to" : {
        "x" : 3613,
        "y" : 396
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 3579,
        "y" : 390
      },
      "b" : {
        "x" : 3591,
        "y" : 402
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 3585,
        "y" : 396
      }
    },
    "inputs" : [ {
      "id" : 38540,
      "points" : [ {
        "x" : 3548,
        "y" : 452
      } ],
      "stoichiometry" : 2
    }, {
      "id" : 38538,
      "points" : [ {
        "x" : 3536,
        "y" : 396
      } ]
    } ],
    "outputs" : [ {
      "id" : 38541,
      "points" : [ {
        "x" : 3633,
        "y" : 427
      } ],
      "stoichiometry" : 2
    }, {
      "id" : 38542,
      "points" : [ {
        "x" : 3677,
        "y" : 396
      } ]
    } ],
    "catalysts" : [ {
      "id" : 38538,
      "points" : [ {
        "x" : 3502,
        "y" : 371
      }, {
        "x" : 3555,
        "y" : 334
      } ]
    } ]
  }, {
    "id" : 38478,
    "reactomeId" : 10029812,
    "displayName" : "SPRY2 binds GRB2",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 6157,
      "y" : 1292
    },
    "minX" : 6151,
    "maxX" : 6163,
    "minY" : 1265,
    "maxY" : 1395,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 6157,
        "y" : 1265
      },
      "to" : {
        "x" : 6157,
        "y" : 1292
      }
    }, {
      "from" : {
        "x" : 6157,
        "y" : 1292
      },
      "to" : {
        "x" : 6155,
        "y" : 1395
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 6151,
        "y" : 1388
      },
      "b" : {
        "x" : 6155,
        "y" : 1395
      },
      "c" : {
        "x" : 6159,
        "y" : 1388
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 6159,
        "y" : 1388
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 6157,
        "y" : 1292
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 6157,
        "y" : 1292
      }
    },
    "inputs" : [ {
      "id" : 38479,
      "points" : [ {
        "x" : 6157,
        "y" : 1231
      } ]
    }, {
      "id" : 38480,
      "points" : [ {
        "x" : 6088,
        "y" : 1309
      } ]
    } ],
    "outputs" : [ {
      "id" : 38481
    } ]
  }, {
    "id" : 38543,
    "reactomeId" : 10057921,
    "displayName" : "Activated FGFR1 binds PLCG1",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 1943,
      "y" : 305
    },
    "minX" : 1919,
    "maxX" : 1966,
    "minY" : 268,
    "maxY" : 343,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 1966,
        "y" : 343
      },
      "to" : {
        "x" : 1943,
        "y" : 305
      }
    }, {
      "from" : {
        "x" : 1943,
        "y" : 305
      },
      "to" : {
        "x" : 1919,
        "y" : 268
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 1926,
        "y" : 272
      },
      "b" : {
        "x" : 1919,
        "y" : 268
      },
      "c" : {
        "x" : 1919,
        "y" : 276
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 1919,
        "y" : 276
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 1943,
        "y" : 305
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 1943,
        "y" : 305
      }
    },
    "inputs" : [ {
      "id" : 38544,
      "points" : [ {
        "x" : 1914,
        "y" : 357
      } ]
    }, {
      "id" : 38517,
      "points" : [ {
        "x" : 2077,
        "y" : 397
      } ]
    }, {
      "id" : 38545,
      "points" : [ {
        "x" : 1985,
        "y" : 332
      } ]
    } ],
    "outputs" : [ {
      "id" : 38546
    } ]
  }, {
    "id" : 38482,
    "reactomeId" : 10029818,
    "displayName" : "SPRY2 binds CBL",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 6067,
      "y" : 1545
    },
    "minX" : 6061,
    "maxX" : 6073,
    "minY" : 1519,
    "maxY" : 1568,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 6066,
        "y" : 1519
      },
      "to" : {
        "x" : 6067,
        "y" : 1545
      }
    }, {
      "from" : {
        "x" : 6067,
        "y" : 1545
      },
      "to" : {
        "x" : 6067,
        "y" : 1568
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 6061,
        "y" : 1539
      },
      "b" : {
        "x" : 6073,
        "y" : 1551
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 6067,
        "y" : 1545
      }
    },
    "inputs" : [ {
      "id" : 38483,
      "points" : [ {
        "x" : 6058,
        "y" : 1490
      } ]
    }, {
      "id" : 38479,
      "points" : [ {
        "x" : 6192,
        "y" : 1231
      }, {
        "x" : 6231,
        "y" : 1246
      }, {
        "x" : 6228,
        "y" : 1456
      } ]
    } ],
    "outputs" : [ {
      "id" : 38484,
      "points" : [ {
        "x" : 6128,
        "y" : 1651
      } ]
    }, {
      "id" : 38485,
      "points" : [ {
        "x" : 6018,
        "y" : 1609
      } ]
    } ]
  }, {
    "id" : 38547,
    "reactomeId" : 10057904,
    "displayName" : "Activated FGFR1 phosphorylates PLCG1",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 1768,
      "y" : 243
    },
    "minX" : 1730,
    "maxX" : 1793,
    "minY" : 237,
    "maxY" : 249,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 1793,
        "y" : 243
      },
      "to" : {
        "x" : 1768,
        "y" : 243
      }
    }, {
      "from" : {
        "x" : 1768,
        "y" : 243
      },
      "to" : {
        "x" : 1730,
        "y" : 245
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 1762,
        "y" : 237
      },
      "b" : {
        "x" : 1774,
        "y" : 249
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 1768,
        "y" : 243
      }
    },
    "inputs" : [ {
      "id" : 38546,
      "points" : [ {
        "x" : 1839,
        "y" : 241
      } ]
    }, {
      "id" : 38548,
      "points" : [ {
        "x" : 1811,
        "y" : 219
      } ],
      "stoichiometry" : 4
    } ],
    "outputs" : [ {
      "id" : 38549,
      "points" : [ {
        "x" : 1696,
        "y" : 246
      } ]
    }, {
      "id" : 38550,
      "points" : [ {
        "x" : 1716,
        "y" : 212
      } ],
      "stoichiometry" : 4
    } ],
    "catalysts" : [ {
      "id" : 38546,
      "points" : [ {
        "x" : 1844,
        "y" : 268
      }, {
        "x" : 1809,
        "y" : 279
      } ]
    } ]
  }, {
    "id" : 38486,
    "reactomeId" : 10022686,
    "displayName" : "Phosphorylated SPRY2 is ubiquitinated by CBL",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 6147,
      "y" : 1775
    },
    "minX" : 6141,
    "maxX" : 6153,
    "minY" : 1737,
    "maxY" : 1838,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 6141,
        "y" : 1737
      },
      "to" : {
        "x" : 6147,
        "y" : 1775
      }
    }, {
      "from" : {
        "x" : 6147,
        "y" : 1775
      },
      "to" : {
        "x" : 6149,
        "y" : 1838
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 6145,
        "y" : 1831
      },
      "b" : {
        "x" : 6149,
        "y" : 1838
      },
      "c" : {
        "x" : 6153,
        "y" : 1831
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 6153,
        "y" : 1831
      }
    },
    "reactionShape" : {
      "a" : {
        "x" : 6141,
        "y" : 1769
      },
      "b" : {
        "x" : 6153,
        "y" : 1781
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 6147,
        "y" : 1775
      }
    },
    "inputs" : [ {
      "id" : 38484,
      "points" : [ {
        "x" : 6141,
        "y" : 1694
      } ]
    }, {
      "id" : 38487,
      "points" : [ {
        "x" : 6038,
        "y" : 1733
      } ]
    } ],
    "outputs" : [ {
      "id" : 38488
    } ],
    "catalysts" : [ {
      "id" : 38484,
      "points" : [ {
        "x" : 6167,
        "y" : 1694
      }, {
        "x" : 6234,
        "y" : 1738
      } ]
    } ]
  }, {
    "id" : 38551,
    "reactomeId" : 10057919,
    "displayName" : "p-4Y-PLCG1 dissociates from activated FGFR1",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 1497,
      "y" : 243
    },
    "minX" : 1491,
    "maxX" : 1578,
    "minY" : 141,
    "maxY" : 249,
    "reactionType" : "dissociation",
    "segments" : [ {
      "from" : {
        "x" : 1578,
        "y" : 246
      },
      "to" : {
        "x" : 1497,
        "y" : 243
      }
    }, {
      "from" : {
        "x" : 1497,
        "y" : 243
      },
      "to" : {
        "x" : 1499,
        "y" : 141
      }
    } ],
    "reactionShape" : {
      "c" : {
        "x" : 1497,
        "y" : 243
      },
      "r" : 5,
      "r1" : 3,
      "type" : "DOUBLE_CIRCLE",
      "empty" : true,
      "centre" : {
        "x" : 1497,
        "y" : 243
      }
    },
    "inputs" : [ {
      "id" : 38549
    } ],
    "outputs" : [ {
      "id" : 38517,
      "points" : [ {
        "x" : 2098,
        "y" : 397
      }, {
        "x" : 2104,
        "y" : 149
      } ]
    }, {
      "id" : 38552,
      "points" : [ {
        "x" : 1452,
        "y" : 165
      } ]
    } ]
  }, {
    "id" : 38489,
    "reactomeId" : 10029816,
    "displayName" : "CBL dissociates from ubiquitinated p-SPRY2",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 6083,
      "y" : 1934
    },
    "minX" : 6067,
    "maxX" : 6129,
    "minY" : 1888,
    "maxY" : 1949,
    "reactionType" : "dissociation",
    "segments" : [ {
      "from" : {
        "x" : 6129,
        "y" : 1888
      },
      "to" : {
        "x" : 6083,
        "y" : 1934
      }
    }, {
      "from" : {
        "x" : 6083,
        "y" : 1934
      },
      "to" : {
        "x" : 6067,
        "y" : 1949
      }
    } ],
    "reactionShape" : {
      "c" : {
        "x" : 6083,
        "y" : 1934
      },
      "r" : 5,
      "r1" : 3,
      "type" : "DOUBLE_CIRCLE",
      "empty" : true,
      "centre" : {
        "x" : 6083,
        "y" : 1934
      }
    },
    "inputs" : [ {
      "id" : 38488
    } ],
    "outputs" : [ {
      "id" : 38483,
      "points" : [ {
        "x" : 6027,
        "y" : 1483
      }, {
        "x" : 5884,
        "y" : 1529
      }, {
        "x" : 5888,
        "y" : 1948
      } ]
    }, {
      "id" : 38490,
      "points" : [ {
        "x" : 6030,
        "y" : 2020
      } ]
    } ]
  }, {
    "id" : 38553,
    "reactomeId" : 10058094,
    "displayName" : "Activated FGFR1 binds SHC1",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 2283,
      "y" : 491
    },
    "minX" : 2249,
    "maxX" : 2302,
    "minY" : 478,
    "maxY" : 530,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 2249,
        "y" : 478
      },
      "to" : {
        "x" : 2283,
        "y" : 491
      }
    }, {
      "from" : {
        "x" : 2283,
        "y" : 491
      },
      "to" : {
        "x" : 2302,
        "y" : 530
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 2295,
        "y" : 526
      },
      "b" : {
        "x" : 2302,
        "y" : 530
      },
      "c" : {
        "x" : 2303,
        "y" : 522
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 2303,
        "y" : 522
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 2283,
        "y" : 491
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 2283,
        "y" : 491
      }
    },
    "inputs" : [ {
      "id" : 38554,
      "points" : [ {
        "x" : 2249,
        "y" : 632
      } ]
    }, {
      "id" : 38517,
      "points" : [ {
        "x" : 2123,
        "y" : 431
      } ]
    } ],
    "outputs" : [ {
      "id" : 38555
    } ]
  }, {
    "id" : 38491,
    "reactomeId" : 10029807,
    "displayName" : "SRC phosphorylates SPRY2 on Y55 and Y227",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 5836,
      "y" : 1141
    },
    "minX" : 5830,
    "maxX" : 5995,
    "minY" : 941,
    "maxY" : 1195,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 5834,
        "y" : 941
      },
      "to" : {
        "x" : 5836,
        "y" : 1141
      }
    }, {
      "from" : {
        "x" : 5836,
        "y" : 1141
      },
      "to" : {
        "x" : 5995,
        "y" : 1195
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 5830,
        "y" : 1135
      },
      "b" : {
        "x" : 5842,
        "y" : 1147
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 5836,
        "y" : 1141
      }
    },
    "inputs" : [ {
      "id" : 38492,
      "points" : [ {
        "x" : 6096,
        "y" : 864
      } ]
    }, {
      "id" : 38493,
      "points" : [ {
        "x" : 5779,
        "y" : 924
      } ],
      "stoichiometry" : 2
    } ],
    "outputs" : [ {
      "id" : 38494,
      "points" : [ {
        "x" : 5951,
        "y" : 1211
      } ],
      "stoichiometry" : 2
    }, {
      "id" : 38479,
      "points" : [ {
        "x" : 6079,
        "y" : 1203
      } ]
    } ],
    "catalysts" : [ {
      "id" : 38495,
      "points" : [ {
        "x" : 5791,
        "y" : 1080
      } ]
    } ],
    "inhibitors" : [ {
      "id" : 38496,
      "points" : [ {
        "x" : 6089,
        "y" : 1132
      } ]
    } ]
  }, {
    "id" : 38556,
    "reactomeId" : 10058105,
    "displayName" : "Activated FGFR1 phosphorylates SHC1",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 2417,
      "y" : 558
    },
    "minX" : 2392,
    "maxX" : 2440,
    "minY" : 552,
    "maxY" : 564,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 2392,
        "y" : 558
      },
      "to" : {
        "x" : 2417,
        "y" : 558
      }
    }, {
      "from" : {
        "x" : 2417,
        "y" : 558
      },
      "to" : {
        "x" : 2440,
        "y" : 558
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 2411,
        "y" : 552
      },
      "b" : {
        "x" : 2423,
        "y" : 564
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 2417,
        "y" : 558
      }
    },
    "inputs" : [ {
      "id" : 38555,
      "points" : [ {
        "x" : 2371,
        "y" : 557
      } ]
    }, {
      "id" : 38557,
      "points" : [ {
        "x" : 2372,
        "y" : 610
      } ],
      "stoichiometry" : 3
    } ],
    "outputs" : [ {
      "id" : 38558,
      "points" : [ {
        "x" : 2468,
        "y" : 556
      } ]
    }, {
      "id" : 38559,
      "points" : [ {
        "x" : 2468,
        "y" : 608
      } ],
      "stoichiometry" : 3
    } ],
    "catalysts" : [ {
      "id" : 38555,
      "points" : [ {
        "x" : 2371,
        "y" : 534
      }, {
        "x" : 2396,
        "y" : 522
      } ]
    } ]
  }, {
    "id" : 38560,
    "reactomeId" : 10058128,
    "displayName" : "Activated FGFR1:p-SHC1 binds GRB2:SOS1",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 3045,
      "y" : 705
    },
    "minX" : 2989,
    "maxX" : 3115,
    "minY" : 582,
    "maxY" : 711,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 2989,
        "y" : 706
      },
      "to" : {
        "x" : 3045,
        "y" : 705
      }
    }, {
      "from" : {
        "x" : 3045,
        "y" : 705
      },
      "to" : {
        "x" : 3115,
        "y" : 582
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 3115,
        "y" : 590
      },
      "b" : {
        "x" : 3115,
        "y" : 582
      },
      "c" : {
        "x" : 3108,
        "y" : 586
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 3108,
        "y" : 586
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 3045,
        "y" : 705
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 3045,
        "y" : 705
      }
    },
    "inputs" : [ {
      "id" : 38558,
      "points" : [ {
        "x" : 2547,
        "y" : 586
      }, {
        "x" : 2613,
        "y" : 698
      } ]
    }, {
      "id" : 38529,
      "points" : [ {
        "x" : 2951,
        "y" : 638
      } ]
    } ],
    "outputs" : [ {
      "id" : 38561
    } ]
  }, {
    "id" : 38497,
    "reactomeId" : 10029791,
    "displayName" : "SPRY2 translocates to the plasma membrane",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 5932,
      "y" : 876
    },
    "minX" : 5903,
    "maxX" : 6096,
    "minY" : 855,
    "maxY" : 882,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 5903,
        "y" : 876
      },
      "to" : {
        "x" : 5932,
        "y" : 876
      }
    }, {
      "from" : {
        "x" : 5932,
        "y" : 876
      },
      "to" : {
        "x" : 6096,
        "y" : 855
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 6090,
        "y" : 860
      },
      "b" : {
        "x" : 6096,
        "y" : 855
      },
      "c" : {
        "x" : 6089,
        "y" : 852
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 6089,
        "y" : 852
      }
    },
    "reactionShape" : {
      "a" : {
        "x" : 5926,
        "y" : 870
      },
      "b" : {
        "x" : 5938,
        "y" : 882
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 5932,
        "y" : 876
      }
    },
    "inputs" : [ {
      "id" : 38498
    } ],
    "outputs" : [ {
      "id" : 38492
    } ]
  }, {
    "id" : 38562,
    "reactomeId" : 10058131,
    "displayName" : "Activated FGFR1:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 3231,
      "y" : 780
    },
    "minX" : 3211,
    "maxX" : 3311,
    "minY" : 774,
    "maxY" : 786,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 3211,
        "y" : 781
      },
      "to" : {
        "x" : 3231,
        "y" : 780
      }
    }, {
      "from" : {
        "x" : 3231,
        "y" : 780
      },
      "to" : {
        "x" : 3311,
        "y" : 781
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 3225,
        "y" : 774
      },
      "b" : {
        "x" : 3237,
        "y" : 786
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 3231,
        "y" : 780
      }
    },
    "inputs" : [ {
      "id" : 38533,
      "points" : [ {
        "x" : 3129,
        "y" : 784
      } ]
    }, {
      "id" : 38534,
      "points" : [ {
        "x" : 3116,
        "y" : 870
      } ]
    } ],
    "outputs" : [ {
      "id" : 38536,
      "points" : [ {
        "x" : 3402,
        "y" : 782
      } ]
    }, {
      "id" : 38535,
      "points" : [ {
        "x" : 3345,
        "y" : 849
      } ]
    } ],
    "catalysts" : [ {
      "id" : 38561,
      "points" : [ {
        "x" : 3141,
        "y" : 582
      } ]
    } ]
  }, {
    "id" : 38563,
    "reactomeId" : 10058120,
    "displayName" : "Activated FGFR1:p-FRS2 binds GRB2:GAB1:PIK3R1",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 4012,
      "y" : 385
    },
    "minX" : 3945,
    "maxX" : 4049,
    "minY" : 321,
    "maxY" : 392,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 3945,
        "y" : 321
      },
      "to" : {
        "x" : 4012,
        "y" : 385
      }
    }, {
      "from" : {
        "x" : 4012,
        "y" : 385
      },
      "to" : {
        "x" : 4049,
        "y" : 392
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 4041,
        "y" : 395
      },
      "b" : {
        "x" : 4049,
        "y" : 392
      },
      "c" : {
        "x" : 4043,
        "y" : 387
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 4043,
        "y" : 387
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 4012,
        "y" : 385
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 4012,
        "y" : 385
      }
    },
    "inputs" : [ {
      "id" : 38477,
      "points" : [ {
        "x" : 3960,
        "y" : 604
      } ]
    }, {
      "id" : 38525,
      "points" : [ {
        "x" : 2765,
        "y" : 351
      }, {
        "x" : 2889,
        "y" : 317
      } ]
    } ],
    "outputs" : [ {
      "id" : 38564
    } ]
  }, {
    "id" : 38499,
    "reactomeId" : 10029826,
    "displayName" : "PPA2A dephosphorylates SPRY2",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 5792,
      "y" : 775
    },
    "minX" : 5786,
    "maxX" : 5798,
    "minY" : 706,
    "maxY" : 810,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 5791,
        "y" : 706
      },
      "to" : {
        "x" : 5792,
        "y" : 775
      }
    }, {
      "from" : {
        "x" : 5792,
        "y" : 775
      },
      "to" : {
        "x" : 5795,
        "y" : 810
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 5786,
        "y" : 769
      },
      "b" : {
        "x" : 5798,
        "y" : 781
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 5792,
        "y" : 775
      }
    },
    "inputs" : [ {
      "id" : 38500
    } ],
    "outputs" : [ {
      "id" : 38501,
      "points" : [ {
        "x" : 5841,
        "y" : 825
      } ],
      "stoichiometry" : 2
    }, {
      "id" : 38498,
      "points" : [ {
        "x" : 5832,
        "y" : 856
      } ]
    } ],
    "catalysts" : [ {
      "id" : 38500,
      "points" : [ {
        "x" : 5777,
        "y" : 706
      }, {
        "x" : 5751,
        "y" : 741
      } ]
    } ]
  }, {
    "id" : 38565,
    "reactomeId" : 10058118,
    "displayName" : "Activated FGFR1:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 4298,
      "y" : 410
    },
    "minX" : 4254,
    "maxX" : 4334,
    "minY" : 404,
    "maxY" : 416,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 4254,
        "y" : 408
      },
      "to" : {
        "x" : 4298,
        "y" : 410
      }
    }, {
      "from" : {
        "x" : 4298,
        "y" : 410
      },
      "to" : {
        "x" : 4334,
        "y" : 408
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 4327,
        "y" : 412
      },
      "b" : {
        "x" : 4334,
        "y" : 408
      },
      "c" : {
        "x" : 4327,
        "y" : 404
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 4327,
        "y" : 404
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 4298,
        "y" : 410
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 4298,
        "y" : 410
      }
    },
    "inputs" : [ {
      "id" : 38564,
      "points" : [ {
        "x" : 4189,
        "y" : 406
      } ]
    }, {
      "id" : 38566,
      "points" : [ {
        "x" : 4254,
        "y" : 623
      } ]
    } ],
    "outputs" : [ {
      "id" : 38567
    } ]
  }, {
    "id" : 38502,
    "reactomeId" : 10022676,
    "displayName" : "SPRY2 is phosphorylated by phosphorylated MNK1",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 6136,
      "y" : 996
    },
    "minX" : 6130,
    "maxX" : 6142,
    "minY" : 960,
    "maxY" : 1035,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 6139,
        "y" : 960
      },
      "to" : {
        "x" : 6136,
        "y" : 996
      }
    }, {
      "from" : {
        "x" : 6136,
        "y" : 996
      },
      "to" : {
        "x" : 6142,
        "y" : 1035
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 6130,
        "y" : 990
      },
      "b" : {
        "x" : 6142,
        "y" : 1002
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 6136,
        "y" : 996
      }
    },
    "inputs" : [ {
      "id" : 38503,
      "points" : [ {
        "x" : 6177,
        "y" : 928
      } ],
      "stoichiometry" : 2
    }, {
      "id" : 38492,
      "points" : [ {
        "x" : 6146,
        "y" : 873
      } ]
    } ],
    "outputs" : [ {
      "id" : 38504,
      "points" : [ {
        "x" : 6184,
        "y" : 1041
      } ],
      "stoichiometry" : 2
    }, {
      "id" : 38496,
      "points" : [ {
        "x" : 6147,
        "y" : 1104
      } ]
    } ],
    "catalysts" : [ {
      "id" : 38505,
      "points" : [ {
        "x" : 5972,
        "y" : 993
      } ]
    } ]
  }, {
    "id" : 38568,
    "reactomeId" : 10058280,
    "displayName" : "FGFR1-associated PI3K phosphorylates PIP2 to PIP3",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 4654,
      "y" : 468
    },
    "minX" : 4628,
    "maxX" : 4682,
    "minY" : 462,
    "maxY" : 474,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 4628,
        "y" : 468
      },
      "to" : {
        "x" : 4654,
        "y" : 468
      }
    }, {
      "from" : {
        "x" : 4654,
        "y" : 468
      },
      "to" : {
        "x" : 4682,
        "y" : 467
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 4648,
        "y" : 462
      },
      "b" : {
        "x" : 4660,
        "y" : 474
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 4654,
        "y" : 468
      }
    },
    "inputs" : [ {
      "id" : 38569,
      "points" : [ {
        "x" : 4539,
        "y" : 495
      } ]
    }, {
      "id" : 38570,
      "points" : [ {
        "x" : 4475,
        "y" : 593
      } ]
    } ],
    "outputs" : [ {
      "id" : 38571,
      "points" : [ {
        "x" : 4765,
        "y" : 595
      } ]
    }, {
      "id" : 38572,
      "points" : [ {
        "x" : 4753,
        "y" : 495
      } ]
    } ],
    "catalysts" : [ {
      "id" : 38567,
      "points" : [ {
        "x" : 4450,
        "y" : 400
      }, {
        "x" : 4635,
        "y" : 378
      } ]
    } ]
  }, {
    "id" : 38506,
    "reactomeId" : 10029803,
    "displayName" : "B-RAF dissociates from S110/S120 p-SPRY2",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 3676,
      "y" : 1124
    },
    "minX" : 3652,
    "maxX" : 3711,
    "minY" : 1118,
    "maxY" : 1130,
    "reactionType" : "dissociation",
    "segments" : [ {
      "from" : {
        "x" : 3652,
        "y" : 1125
      },
      "to" : {
        "x" : 3676,
        "y" : 1124
      }
    }, {
      "from" : {
        "x" : 3676,
        "y" : 1124
      },
      "to" : {
        "x" : 3711,
        "y" : 1123
      }
    } ],
    "reactionShape" : {
      "c" : {
        "x" : 3676,
        "y" : 1124
      },
      "r" : 5,
      "r1" : 3,
      "type" : "DOUBLE_CIRCLE",
      "empty" : true,
      "centre" : {
        "x" : 3676,
        "y" : 1124
      }
    },
    "inputs" : [ {
      "id" : 38507
    } ],
    "outputs" : [ {
      "id" : 38508,
      "points" : [ {
        "x" : 3749,
        "y" : 1159
      } ]
    }, {
      "id" : 38509,
      "points" : [ {
        "x" : 3757,
        "y" : 1123
      } ]
    } ]
  }, {
    "id" : 38573,
    "reactomeId" : 10058283,
    "displayName" : "FGFR1- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 4659,
      "y" : 519
    },
    "minX" : 4639,
    "maxX" : 4688,
    "minY" : 513,
    "maxY" : 525,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 4639,
        "y" : 517
      },
      "to" : {
        "x" : 4659,
        "y" : 519
      }
    }, {
      "from" : {
        "x" : 4659,
        "y" : 519
      },
      "to" : {
        "x" : 4688,
        "y" : 517
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 4653,
        "y" : 513
      },
      "b" : {
        "x" : 4665,
        "y" : 525
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 4659,
        "y" : 519
      }
    },
    "inputs" : [ {
      "id" : 38569,
      "points" : [ {
        "x" : 4539,
        "y" : 508
      } ]
    }, {
      "id" : 38570,
      "points" : [ {
        "x" : 4483,
        "y" : 593
      } ]
    } ],
    "outputs" : [ {
      "id" : 38572,
      "points" : [ {
        "x" : 4747,
        "y" : 513
      } ]
    }, {
      "id" : 38571,
      "points" : [ {
        "x" : 4761,
        "y" : 595
      } ]
    } ],
    "catalysts" : [ {
      "id" : 38574,
      "points" : [ {
        "x" : 4454,
        "y" : 482
      }, {
        "x" : 4543,
        "y" : 432
      } ]
    } ]
  }, {
    "id" : 38510,
    "reactomeId" : 10029830,
    "displayName" : "SPRY2 is serine phosphorylated in response to MAPK activation",
    "schemaClass" : "BlackBoxEvent",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 3521,
      "y" : 1129
    },
    "minX" : 3453,
    "maxX" : 3550,
    "minY" : 1123,
    "maxY" : 1135,
    "reactionType" : "omitted",
    "segments" : [ {
      "from" : {
        "x" : 3453,
        "y" : 1128
      },
      "to" : {
        "x" : 3521,
        "y" : 1129
      }
    }, {
      "from" : {
        "x" : 3521,
        "y" : 1129
      },
      "to" : {
        "x" : 3550,
        "y" : 1128
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 3543,
        "y" : 1132
      },
      "b" : {
        "x" : 3550,
        "y" : 1128
      },
      "c" : {
        "x" : 3543,
        "y" : 1124
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 3543,
        "y" : 1124
      }
    },
    "reactionShape" : {
      "a" : {
        "x" : 3515,
        "y" : 1123
      },
      "b" : {
        "x" : 3527,
        "y" : 1135
      },
      "s" : "\\\\",
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 3521,
        "y" : 1129
      }
    },
    "inputs" : [ {
      "id" : 38511
    } ],
    "outputs" : [ {
      "id" : 38507
    } ],
    "activators" : [ {
      "id" : 38512,
      "points" : [ {
        "x" : 3477,
        "y" : 1078
      }, {
        "x" : 3500,
        "y" : 1082
      } ]
    } ]
  }, {
    "id" : 38447,
    "reactomeId" : 10000607,
    "displayName" : "FGFR1b binds to FGF",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 403,
      "y" : 600
    },
    "minX" : 397,
    "maxX" : 409,
    "minY" : 581,
    "maxY" : 637,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 403,
        "y" : 581
      },
      "to" : {
        "x" : 403,
        "y" : 600
      }
    }, {
      "from" : {
        "x" : 403,
        "y" : 600
      },
      "to" : {
        "x" : 407,
        "y" : 637
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 402,
        "y" : 631
      },
      "b" : {
        "x" : 407,
        "y" : 637
      },
      "c" : {
        "x" : 410,
        "y" : 630
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 410,
        "y" : 630
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 403,
        "y" : 600
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 403,
        "y" : 600
      }
    },
    "inputs" : [ {
      "id" : 38448,
      "points" : [ {
        "x" : 381,
        "y" : 432
      } ],
      "stoichiometry" : 2
    }, {
      "id" : 38449,
      "points" : [ {
        "x" : 100,
        "y" : 521
      } ],
      "stoichiometry" : 2
    }, {
      "id" : 38450,
      "points" : [ {
        "x" : 109,
        "y" : 586
      } ]
    } ],
    "outputs" : [ {
      "id" : 38451
    } ],
    "activators" : [ {
      "id" : 38450,
      "points" : [ {
        "x" : 109,
        "y" : 598
      }, {
        "x" : 314,
        "y" : 648
      } ]
    }, {
      "id" : 38452,
      "points" : [ {
        "x" : 696,
        "y" : 491
      } ]
    } ]
  }, {
    "id" : 38575,
    "reactomeId" : 10058122,
    "displayName" : "Activated FGFR1:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 4025,
      "y" : 504
    },
    "minX" : 3980,
    "maxX" : 4062,
    "minY" : 498,
    "maxY" : 510,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 3980,
        "y" : 504
      },
      "to" : {
        "x" : 4025,
        "y" : 504
      }
    }, {
      "from" : {
        "x" : 4025,
        "y" : 504
      },
      "to" : {
        "x" : 4062,
        "y" : 509
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 4055,
        "y" : 512
      },
      "b" : {
        "x" : 4062,
        "y" : 509
      },
      "c" : {
        "x" : 4056,
        "y" : 504
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 4056,
        "y" : 504
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 4025,
        "y" : 504
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 4025,
        "y" : 504
      }
    },
    "inputs" : [ {
      "id" : 38477,
      "points" : [ {
        "x" : 3964,
        "y" : 604
      } ]
    }, {
      "id" : 38576,
      "points" : [ {
        "x" : 3902,
        "y" : 498
      } ]
    } ],
    "outputs" : [ {
      "id" : 38577
    } ]
  }, {
    "id" : 38513,
    "reactomeId" : 10033754,
    "displayName" : "PPTN11 dephosphorylates SPRY2",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 5985,
      "y" : 1360
    },
    "minX" : 5975,
    "maxX" : 6088,
    "minY" : 1264,
    "maxY" : 1399,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 6088,
        "y" : 1399
      },
      "to" : {
        "x" : 5985,
        "y" : 1360
      }
    }, {
      "from" : {
        "x" : 5985,
        "y" : 1360
      },
      "to" : {
        "x" : 5975,
        "y" : 1264
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 5979,
        "y" : 1354
      },
      "b" : {
        "x" : 5991,
        "y" : 1366
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 5985,
        "y" : 1360
      }
    },
    "inputs" : [ {
      "id" : 38481
    } ],
    "outputs" : [ {
      "id" : 38480,
      "points" : [ {
        "x" : 6028,
        "y" : 1303
      } ]
    }, {
      "id" : 38479,
      "points" : [ {
        "x" : 6098,
        "y" : 1231
      } ]
    } ],
    "catalysts" : [ {
      "id" : 38514,
      "points" : [ {
        "x" : 3387,
        "y" : 645
      }, {
        "x" : 5282,
        "y" : 1375
      } ]
    } ]
  }, {
    "id" : 38578,
    "reactomeId" : 10058124,
    "displayName" : "Activated FGFR1:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 4309,
      "y" : 516
    },
    "minX" : 4278,
    "maxX" : 4332,
    "minY" : 510,
    "maxY" : 522,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 4278,
        "y" : 516
      },
      "to" : {
        "x" : 4309,
        "y" : 516
      }
    }, {
      "from" : {
        "x" : 4309,
        "y" : 516
      },
      "to" : {
        "x" : 4332,
        "y" : 516
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 4325,
        "y" : 520
      },
      "b" : {
        "x" : 4332,
        "y" : 516
      },
      "c" : {
        "x" : 4325,
        "y" : 512
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 4325,
        "y" : 512
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 4309,
        "y" : 516
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 4309,
        "y" : 516
      }
    },
    "inputs" : [ {
      "id" : 38577,
      "points" : [ {
        "x" : 4184,
        "y" : 516
      } ]
    }, {
      "id" : 38566,
      "points" : [ {
        "x" : 4258,
        "y" : 623
      } ]
    } ],
    "outputs" : [ {
      "id" : 38574
    } ]
  }, {
    "id" : 38579,
    "reactomeId" : 10058076,
    "displayName" : "Activated ERK1/2 threonine-phosphorylates FGFR1-associated FRS2",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 2685,
      "y" : 543
    },
    "minX" : 2642,
    "maxX" : 2719,
    "minY" : 537,
    "maxY" : 549,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 2642,
        "y" : 543
      },
      "to" : {
        "x" : 2685,
        "y" : 543
      }
    }, {
      "from" : {
        "x" : 2685,
        "y" : 543
      },
      "to" : {
        "x" : 2719,
        "y" : 543
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 2679,
        "y" : 537
      },
      "b" : {
        "x" : 2691,
        "y" : 549
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 2685,
        "y" : 543
      }
    },
    "inputs" : [ {
      "id" : 38518,
      "points" : [ {
        "x" : 2411,
        "y" : 368
      } ]
    }, {
      "id" : 38580,
      "points" : [ {
        "x" : 2618,
        "y" : 608
      } ],
      "stoichiometry" : 8
    } ],
    "outputs" : [ {
      "id" : 38581,
      "points" : [ {
        "x" : 2752,
        "y" : 552
      } ]
    }, {
      "id" : 38582,
      "points" : [ {
        "x" : 2744,
        "y" : 621
      } ],
      "stoichiometry" : 8
    } ],
    "catalysts" : [ {
      "id" : 38512,
      "points" : [ {
        "x" : 3338,
        "y" : 1069
      }, {
        "x" : 2680,
        "y" : 1066
      } ]
    } ]
  }, {
    "id" : 38515,
    "reactomeId" : 10058084,
    "displayName" : "Activated FGFR1 binds FRS2",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 2272,
      "y" : 343
    },
    "minX" : 2225,
    "maxX" : 2332,
    "minY" : 337,
    "maxY" : 349,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 2225,
        "y" : 341
      },
      "to" : {
        "x" : 2272,
        "y" : 343
      }
    }, {
      "from" : {
        "x" : 2272,
        "y" : 343
      },
      "to" : {
        "x" : 2332,
        "y" : 345
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 2325,
        "y" : 349
      },
      "b" : {
        "x" : 2332,
        "y" : 345
      },
      "c" : {
        "x" : 2325,
        "y" : 341
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 2325,
        "y" : 341
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 2272,
        "y" : 343
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 2272,
        "y" : 343
      }
    },
    "inputs" : [ {
      "id" : 38516,
      "points" : [ {
        "x" : 2232,
        "y" : 384
      } ]
    }, {
      "id" : 38517,
      "points" : [ {
        "x" : 2117,
        "y" : 397
      } ]
    } ],
    "outputs" : [ {
      "id" : 38518
    } ]
  }, {
    "id" : 38453,
    "reactomeId" : 10000709,
    "displayName" : "Autocatalytic phosphorylation of FGFR1b",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 407,
      "y" : 752
    },
    "minX" : 401,
    "maxX" : 413,
    "minY" : 727,
    "maxY" : 775,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 410,
        "y" : 727
      },
      "to" : {
        "x" : 407,
        "y" : 752
      }
    }, {
      "from" : {
        "x" : 407,
        "y" : 752
      },
      "to" : {
        "x" : 406,
        "y" : 775
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 401,
        "y" : 746
      },
      "b" : {
        "x" : 413,
        "y" : 758
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 407,
        "y" : 752
      }
    },
    "inputs" : [ {
      "id" : 38451,
      "points" : [ {
        "x" : 410,
        "y" : 697
      } ]
    }, {
      "id" : 38454,
      "points" : [ {
        "x" : 473,
        "y" : 715
      } ],
      "stoichiometry" : 16
    } ],
    "outputs" : [ {
      "id" : 38455,
      "points" : [ {
        "x" : 414,
        "y" : 809
      } ]
    }, {
      "id" : 38456,
      "points" : [ {
        "x" : 460,
        "y" : 787
      } ],
      "stoichiometry" : 16
    } ],
    "catalysts" : [ {
      "id" : 38451,
      "points" : [ {
        "x" : 385,
        "y" : 697
      }, {
        "x" : 345,
        "y" : 739
      } ]
    } ]
  }, {
    "id" : 38583,
    "reactomeId" : 10058256,
    "displayName" : "p-CBL:GRB2 binds p-FRS2:activated FGFR1",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 5067,
      "y" : 518
    },
    "minX" : 5032,
    "maxX" : 5095,
    "minY" : 512,
    "maxY" : 524,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 5032,
        "y" : 518
      },
      "to" : {
        "x" : 5067,
        "y" : 518
      }
    }, {
      "from" : {
        "x" : 5067,
        "y" : 518
      },
      "to" : {
        "x" : 5095,
        "y" : 514
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 5089,
        "y" : 519
      },
      "b" : {
        "x" : 5095,
        "y" : 514
      },
      "c" : {
        "x" : 5088,
        "y" : 511
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 5088,
        "y" : 511
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 5067,
        "y" : 518
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 5067,
        "y" : 518
      }
    },
    "inputs" : [ {
      "id" : 38584,
      "points" : [ {
        "x" : 4928,
        "y" : 605
      } ]
    }, {
      "id" : 38576,
      "points" : [ {
        "x" : 3846,
        "y" : 457
      }, {
        "x" : 3927,
        "y" : 294
      }, {
        "x" : 4890,
        "y" : 297
      } ]
    } ],
    "outputs" : [ {
      "id" : 38585
    } ]
  }, {
    "id" : 38519,
    "reactomeId" : 10058090,
    "displayName" : "Activated FGFR1 binds FRS3",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 2288,
      "y" : 260
    },
    "minX" : 2255,
    "maxX" : 2329,
    "minY" : 254,
    "maxY" : 266,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 2255,
        "y" : 258
      },
      "to" : {
        "x" : 2288,
        "y" : 260
      }
    }, {
      "from" : {
        "x" : 2288,
        "y" : 260
      },
      "to" : {
        "x" : 2329,
        "y" : 259
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 2322,
        "y" : 263
      },
      "b" : {
        "x" : 2329,
        "y" : 259
      },
      "c" : {
        "x" : 2322,
        "y" : 255
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 2322,
        "y" : 255
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 2288,
        "y" : 260
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 2288,
        "y" : 260
      }
    },
    "inputs" : [ {
      "id" : 38520,
      "points" : [ {
        "x" : 2221,
        "y" : 239
      } ]
    }, {
      "id" : 38517,
      "points" : [ {
        "x" : 2109,
        "y" : 397
      } ]
    } ],
    "outputs" : [ {
      "id" : 38521
    } ]
  }, {
    "id" : 38457,
    "reactomeId" : 10000612,
    "displayName" : "FGFR1c binds to FGF",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 285,
      "y" : 1099
    },
    "minX" : 279,
    "maxX" : 291,
    "minY" : 1067,
    "maxY" : 1258,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 283,
        "y" : 1067
      },
      "to" : {
        "x" : 285,
        "y" : 1099
      }
    }, {
      "from" : {
        "x" : 285,
        "y" : 1099
      },
      "to" : {
        "x" : 283,
        "y" : 1258
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 279,
        "y" : 1251
      },
      "b" : {
        "x" : 283,
        "y" : 1258
      },
      "c" : {
        "x" : 287,
        "y" : 1251
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 287,
        "y" : 1251
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 285,
        "y" : 1099
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 285,
        "y" : 1099
      }
    },
    "inputs" : [ {
      "id" : 38458,
      "points" : [ {
        "x" : 115,
        "y" : 967
      } ],
      "stoichiometry" : 2
    }, {
      "id" : 38459,
      "points" : [ {
        "x" : 259,
        "y" : 902
      } ],
      "stoichiometry" : 2
    }, {
      "id" : 38460,
      "points" : [ {
        "x" : 180,
        "y" : 1056
      } ]
    } ],
    "outputs" : [ {
      "id" : 38461
    } ],
    "activators" : [ {
      "id" : 38460,
      "points" : [ {
        "x" : 180,
        "y" : 1066
      }, {
        "x" : 219,
        "y" : 1079
      } ]
    }, {
      "id" : 38452,
      "points" : [ {
        "x" : 717,
        "y" : 491
      } ]
    } ]
  }, {
    "id" : 38586,
    "reactomeId" : 10058254,
    "displayName" : "CBL ubiquitinates FRS2 and FGFR1",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 5337,
      "y" : 510
    },
    "minX" : 5304,
    "maxX" : 5378,
    "minY" : 504,
    "maxY" : 516,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 5304,
        "y" : 509
      },
      "to" : {
        "x" : 5337,
        "y" : 510
      }
    }, {
      "from" : {
        "x" : 5337,
        "y" : 510
      },
      "to" : {
        "x" : 5378,
        "y" : 510
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 5371,
        "y" : 514
      },
      "b" : {
        "x" : 5378,
        "y" : 510
      },
      "c" : {
        "x" : 5371,
        "y" : 506
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 5371,
        "y" : 506
      }
    },
    "reactionShape" : {
      "a" : {
        "x" : 5331,
        "y" : 504
      },
      "b" : {
        "x" : 5343,
        "y" : 516
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 5337,
        "y" : 510
      }
    },
    "inputs" : [ {
      "id" : 38585,
      "points" : [ {
        "x" : 5267,
        "y" : 507
      } ]
    }, {
      "id" : 38587,
      "points" : [ {
        "x" : 5282,
        "y" : 615
      } ]
    } ],
    "outputs" : [ {
      "id" : 38588
    } ],
    "catalysts" : [ {
      "id" : 38585,
      "points" : [ {
        "x" : 5267,
        "y" : 480
      }, {
        "x" : 5307,
        "y" : 468
      } ]
    } ]
  }, {
    "id" : 38522,
    "reactomeId" : 10058097,
    "displayName" : "Activated FGFR1 phosphorylates FRS2",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 2527,
      "y" : 354
    },
    "minX" : 2501,
    "maxX" : 2557,
    "minY" : 348,
    "maxY" : 360,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 2501,
        "y" : 356
      },
      "to" : {
        "x" : 2527,
        "y" : 354
      }
    }, {
      "from" : {
        "x" : 2527,
        "y" : 354
      },
      "to" : {
        "x" : 2557,
        "y" : 355
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 2521,
        "y" : 348
      },
      "b" : {
        "x" : 2533,
        "y" : 360
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 2527,
        "y" : 354
      }
    },
    "inputs" : [ {
      "id" : 38518,
      "points" : [ {
        "x" : 2445,
        "y" : 351
      } ]
    }, {
      "id" : 38523,
      "points" : [ {
        "x" : 2489,
        "y" : 335
      } ],
      "stoichiometry" : 6
    } ],
    "outputs" : [ {
      "id" : 38524,
      "points" : [ {
        "x" : 2577,
        "y" : 338
      } ],
      "stoichiometry" : 6
    }, {
      "id" : 38525,
      "points" : [ {
        "x" : 2640,
        "y" : 362
      } ]
    } ],
    "catalysts" : [ {
      "id" : 38518,
      "points" : [ {
        "x" : 2421,
        "y" : 368
      }, {
        "x" : 2470,
        "y" : 391
      } ]
    } ]
  }, {
    "id" : 38589,
    "reactomeId" : 10058069,
    "displayName" : "FGFRL1 dimer binds FGFs",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 276,
      "y" : 2048
    },
    "minX" : 270,
    "maxX" : 282,
    "minY" : 1998,
    "maxY" : 2100,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 274,
        "y" : 1998
      },
      "to" : {
        "x" : 276,
        "y" : 2048
      }
    }, {
      "from" : {
        "x" : 276,
        "y" : 2048
      },
      "to" : {
        "x" : 276,
        "y" : 2100
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 272,
        "y" : 2093
      },
      "b" : {
        "x" : 276,
        "y" : 2100
      },
      "c" : {
        "x" : 280,
        "y" : 2093
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 280,
        "y" : 2093
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 276,
        "y" : 2048
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 276,
        "y" : 2048
      }
    },
    "inputs" : [ {
      "id" : 38590,
      "points" : [ {
        "x" : 274,
        "y" : 1943
      } ]
    }, {
      "id" : 38591,
      "points" : [ {
        "x" : 119,
        "y" : 1901
      } ],
      "stoichiometry" : 2
    }, {
      "id" : 38592,
      "points" : [ {
        "x" : 149,
        "y" : 1992
      } ]
    } ],
    "outputs" : [ {
      "id" : 38593
    } ]
  }, {
    "id" : 38462,
    "reactomeId" : 10000712,
    "displayName" : "Autocatalytic phosphorylation of FGFR1c",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 282,
      "y" : 1340
    },
    "minX" : 276,
    "maxX" : 288,
    "minY" : 1323,
    "maxY" : 1355,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 281,
        "y" : 1323
      },
      "to" : {
        "x" : 282,
        "y" : 1340
      }
    }, {
      "from" : {
        "x" : 282,
        "y" : 1340
      },
      "to" : {
        "x" : 281,
        "y" : 1355
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 276,
        "y" : 1334
      },
      "b" : {
        "x" : 288,
        "y" : 1346
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 282,
        "y" : 1340
      }
    },
    "inputs" : [ {
      "id" : 38463,
      "points" : [ {
        "x" : 326,
        "y" : 1320
      } ],
      "stoichiometry" : 16
    }, {
      "id" : 38461,
      "points" : [ {
        "x" : 282,
        "y" : 1300
      } ]
    } ],
    "outputs" : [ {
      "id" : 38464,
      "points" : [ {
        "x" : 314,
        "y" : 1357
      } ],
      "stoichiometry" : 16
    }, {
      "id" : 38465,
      "points" : [ {
        "x" : 281,
        "y" : 1376
      } ]
    } ],
    "catalysts" : [ {
      "id" : 38461,
      "points" : [ {
        "x" : 256,
        "y" : 1300
      }, {
        "x" : 225,
        "y" : 1319
      } ]
    } ]
  }, {
    "id" : 38526,
    "reactomeId" : 10058100,
    "displayName" : "Activated FGFR1 phosphorylates FRS3",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 2531,
      "y" : 253
    },
    "minX" : 2507,
    "maxX" : 2558,
    "minY" : 247,
    "maxY" : 259,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 2507,
        "y" : 253
      },
      "to" : {
        "x" : 2531,
        "y" : 253
      }
    }, {
      "from" : {
        "x" : 2531,
        "y" : 253
      },
      "to" : {
        "x" : 2558,
        "y" : 252
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 2525,
        "y" : 247
      },
      "b" : {
        "x" : 2537,
        "y" : 259
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 2531,
        "y" : 253
      }
    },
    "inputs" : [ {
      "id" : 38521,
      "points" : [ {
        "x" : 2444,
        "y" : 255
      } ]
    }, {
      "id" : 38523,
      "points" : [ {
        "x" : 2487,
        "y" : 300
      } ],
      "stoichiometry" : 5
    } ],
    "outputs" : [ {
      "id" : 38527,
      "points" : [ {
        "x" : 2648,
        "y" : 253
      } ]
    }, {
      "id" : 38524,
      "points" : [ {
        "x" : 2584,
        "y" : 302
      } ],
      "stoichiometry" : 5
    } ],
    "catalysts" : [ {
      "id" : 38521,
      "points" : [ {
        "x" : 2402,
        "y" : 229
      }, {
        "x" : 2444,
        "y" : 165
      } ]
    } ]
  } ],
  "compartments" : [ {
    "id" : 38601,
    "reactomeId" : 70101,
    "displayName" : "cytosol",
    "schemaClass" : "Compartment",
    "renderableClass" : "Compartment",
    "position" : {
      "x" : 3185,
      "y" : 1082
    },
    "minX" : 164,
    "maxX" : 6206,
    "minY" : 0,
    "maxY" : 2164,
    "prop" : {
      "x" : 164,
      "y" : 0,
      "width" : 6042,
      "height" : 2164
    },
    "textPosition" : {
      "x" : 1542,
      "y" : 781
    },
    "insets" : {
      "x" : 174,
      "y" : 10,
      "width" : 6022,
      "height" : 2144
    },
    "bgColor" : {
      "r" : 250,
      "g" : 240,
      "b" : 240
    },
    "componentIds" : [ 38529, 38475, 38474, 38476, 38544, 38535, 38554, 38514, 38477, 38536, 38533, 38534, 38587, 38584, 38566, 38512, 38552, 38516, 38520, 38572, 38569, 38602, 38634, 38498, 38493, 38494, 38511, 38507, 38508, 38509, 38506, 38510, 38603, 38635, 38545, 38495, 38487, 38485, 38500, 38505, 38491, 38499, 38513, 38480, 38484, 38483, 38488, 38479, 38501, 38503, 38504, 38497, 38492, 38481, 38496, 38490, 38482, 38486, 38489, 38502, 38478, 38451, 38455, 38461, 38465, 38469, 38473, 38448, 38459, 38463, 38464, 38471, 38472, 38447, 38453, 38457, 38462, 38466, 38470, 38636, 38637, 38609, 38639, 38610, 38640, 38638, 38460, 38641, 38642, 38643, 38515, 38517, 38518, 38519, 38521, 38522, 38523, 38524, 38525, 38526, 38527, 38528, 38530, 38644, 38645, 38531, 38532, 38537, 38538, 38539, 38541, 38542, 38543, 38546, 38547, 38548, 38549, 38550, 38551, 38553, 38555, 38556, 38557, 38558, 38559, 38560, 38561, 38562, 38563, 38564, 38565, 38567, 38568, 38570, 38571, 38573, 38574, 38575, 38576, 38577, 38578, 38579, 38580, 38581, 38582, 38583, 38585, 38586, 38588, 38593, 38590, 38589, 38594, 38596, 38595, 38598, 38599, 38454, 38456, 38597, 38611, 38646, 38647, 38540, 38648, 38600, 38649, 38650, 38651, 38652, 38653, 38452 ]
  } ],
  "notes" : [ ],
  "links" : [ {
    "id" : 38641,
    "renderableClass" : "EntitySetAndMemberLink",
    "position" : {
      "x" : 1216,
      "y" : 1506
    },
    "minX" : 345,
    "maxX" : 2089,
    "minY" : 431,
    "maxY" : 1512,
    "segments" : [ {
      "from" : {
        "x" : 345,
        "y" : 1411
      },
      "to" : {
        "x" : 1216,
        "y" : 1506
      }
    }, {
      "from" : {
        "x" : 1216,
        "y" : 1506
      },
      "to" : {
        "x" : 2089,
        "y" : 431
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 1210,
        "y" : 1500
      },
      "b" : {
        "x" : 1222,
        "y" : 1512
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 1216,
        "y" : 1506
      }
    },
    "inputs" : [ {
      "id" : 38465
    } ],
    "outputs" : [ {
      "id" : 38517
    } ]
  }, {
    "id" : 38642,
    "renderableClass" : "EntitySetAndMemberLink",
    "position" : {
      "x" : 1325,
      "y" : 778
    },
    "minX" : 483,
    "maxX" : 2084,
    "minY" : 431,
    "maxY" : 868,
    "segments" : [ {
      "from" : {
        "x" : 483,
        "y" : 836
      },
      "to" : {
        "x" : 899,
        "y" : 868
      }
    }, {
      "from" : {
        "x" : 899,
        "y" : 868
      },
      "to" : {
        "x" : 1752,
        "y" : 689
      }
    }, {
      "from" : {
        "x" : 1752,
        "y" : 689
      },
      "to" : {
        "x" : 2084,
        "y" : 431
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 1319,
        "y" : 772
      },
      "b" : {
        "x" : 1331,
        "y" : 784
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 1325,
        "y" : 778
      }
    },
    "inputs" : [ {
      "id" : 38455
    } ],
    "outputs" : [ {
      "id" : 38517
    } ]
  }, {
    "id" : 38643,
    "renderableClass" : "EntitySetAndMemberLink",
    "position" : {
      "x" : 1218,
      "y" : 1559
    },
    "minX" : 358,
    "maxX" : 2089,
    "minY" : 431,
    "maxY" : 1806,
    "segments" : [ {
      "from" : {
        "x" : 358,
        "y" : 1806
      },
      "to" : {
        "x" : 1218,
        "y" : 1559
      }
    }, {
      "from" : {
        "x" : 1218,
        "y" : 1559
      },
      "to" : {
        "x" : 2089,
        "y" : 431
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 1212,
        "y" : 1553
      },
      "b" : {
        "x" : 1224,
        "y" : 1565
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 1218,
        "y" : 1559
      }
    },
    "inputs" : [ {
      "id" : 38473
    } ],
    "outputs" : [ {
      "id" : 38517
    } ]
  }, {
    "id" : 38644,
    "renderableClass" : "EntitySetAndMemberLink",
    "position" : {
      "x" : 2796,
      "y" : 351
    },
    "minX" : 2731,
    "maxX" : 2862,
    "minY" : 282,
    "maxY" : 420,
    "segments" : [ {
      "from" : {
        "x" : 2731,
        "y" : 282
      },
      "to" : {
        "x" : 2862,
        "y" : 420
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 2790,
        "y" : 345
      },
      "b" : {
        "x" : 2802,
        "y" : 357
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 2796,
        "y" : 351
      }
    },
    "inputs" : [ {
      "id" : 38527
    } ],
    "outputs" : [ {
      "id" : 38530
    } ]
  }, {
    "id" : 38645,
    "renderableClass" : "EntitySetAndMemberLink",
    "position" : {
      "x" : 2801,
      "y" : 405
    },
    "minX" : 2765,
    "maxX" : 2837,
    "minY" : 390,
    "maxY" : 420,
    "segments" : [ {
      "from" : {
        "x" : 2765,
        "y" : 390
      },
      "to" : {
        "x" : 2837,
        "y" : 420
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 2795,
        "y" : 399
      },
      "b" : {
        "x" : 2807,
        "y" : 411
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 2801,
        "y" : 405
      }
    },
    "inputs" : [ {
      "id" : 38525
    } ],
    "outputs" : [ {
      "id" : 38530
    } ]
  }, {
    "id" : 38646,
    "renderableClass" : "Interaction",
    "position" : {
      "x" : 3425,
      "y" : 852
    },
    "minX" : 3412,
    "maxX" : 3439,
    "minY" : 807,
    "maxY" : 897,
    "interactionType" : "Activate",
    "segments" : [ {
      "from" : {
        "x" : 3439,
        "y" : 807
      },
      "to" : {
        "x" : 3412,
        "y" : 897
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 3410,
        "y" : 889
      },
      "b" : {
        "x" : 3412,
        "y" : 897
      },
      "c" : {
        "x" : 3418,
        "y" : 892
      },
      "type" : "ARROW",
      "empty" : true,
      "centre" : {
        "x" : 3418,
        "y" : 892
      }
    },
    "reactionShape" : {
      "a" : {
        "x" : 3419,
        "y" : 846
      },
      "b" : {
        "x" : 3431,
        "y" : 858
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 3425,
        "y" : 852
      }
    },
    "inputs" : [ {
      "id" : 38536
    } ],
    "outputs" : [ {
      "id" : 38611
    } ]
  }, {
    "id" : 38647,
    "renderableClass" : "Interaction",
    "position" : {
      "x" : 3682,
      "y" : 1031
    },
    "minX" : 3476,
    "maxX" : 3770,
    "minY" : 958,
    "maxY" : 1109,
    "interactionType" : "Activate",
    "segments" : [ {
      "from" : {
        "x" : 3476,
        "y" : 958
      },
      "to" : {
        "x" : 3682,
        "y" : 1031
      }
    }, {
      "from" : {
        "x" : 3682,
        "y" : 1031
      },
      "to" : {
        "x" : 3770,
        "y" : 1109
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 3762,
        "y" : 1107
      },
      "b" : {
        "x" : 3770,
        "y" : 1109
      },
      "c" : {
        "x" : 3767,
        "y" : 1101
      },
      "type" : "ARROW",
      "empty" : true,
      "centre" : {
        "x" : 3767,
        "y" : 1101
      }
    },
    "reactionShape" : {
      "a" : {
        "x" : 3676,
        "y" : 1025
      },
      "b" : {
        "x" : 3688,
        "y" : 1037
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 3682,
        "y" : 1031
      }
    },
    "inputs" : [ {
      "id" : 38611
    } ],
    "outputs" : [ {
      "id" : 38509
    } ]
  }, {
    "id" : 38648,
    "renderableClass" : "Interaction",
    "position" : {
      "x" : 3404,
      "y" : 1011
    },
    "minX" : 3398,
    "maxX" : 3410,
    "minY" : 973,
    "maxY" : 1050,
    "interactionType" : "Activate",
    "segments" : [ {
      "from" : {
        "x" : 3403,
        "y" : 973
      },
      "to" : {
        "x" : 3406,
        "y" : 1050
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 3402,
        "y" : 1043
      },
      "b" : {
        "x" : 3406,
        "y" : 1050
      },
      "c" : {
        "x" : 3410,
        "y" : 1043
      },
      "type" : "ARROW",
      "empty" : true,
      "centre" : {
        "x" : 3410,
        "y" : 1043
      }
    },
    "reactionShape" : {
      "a" : {
        "x" : 3398,
        "y" : 1005
      },
      "b" : {
        "x" : 3410,
        "y" : 1017
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 3404,
        "y" : 1011
      }
    },
    "inputs" : [ {
      "id" : 38611
    } ],
    "outputs" : [ {
      "id" : 38512
    } ]
  }, {
    "id" : 38634,
    "renderableClass" : "Interaction",
    "position" : {
      "x" : 4800,
      "y" : 476
    },
    "minX" : 4792,
    "maxX" : 4809,
    "minY" : 458,
    "maxY" : 495,
    "interactionType" : "Activate",
    "segments" : [ {
      "from" : {
        "x" : 4792,
        "y" : 495
      },
      "to" : {
        "x" : 4809,
        "y" : 458
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 4810,
        "y" : 466
      },
      "b" : {
        "x" : 4809,
        "y" : 458
      },
      "c" : {
        "x" : 4802,
        "y" : 463
      },
      "type" : "ARROW",
      "empty" : true,
      "centre" : {
        "x" : 4802,
        "y" : 463
      }
    },
    "reactionShape" : {
      "a" : {
        "x" : 4794,
        "y" : 470
      },
      "b" : {
        "x" : 4806,
        "y" : 482
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 4800,
        "y" : 476
      }
    },
    "inputs" : [ {
      "id" : 38572
    } ],
    "outputs" : [ {
      "id" : 38602
    } ]
  }, {
    "id" : 38635,
    "renderableClass" : "Interaction",
    "position" : {
      "x" : 1397,
      "y" : 137
    },
    "minX" : 1391,
    "maxX" : 1403,
    "minY" : 115,
    "maxY" : 160,
    "interactionType" : "Activate",
    "segments" : [ {
      "from" : {
        "x" : 1398,
        "y" : 160
      },
      "to" : {
        "x" : 1397,
        "y" : 115
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 1401,
        "y" : 122
      },
      "b" : {
        "x" : 1397,
        "y" : 115
      },
      "c" : {
        "x" : 1393,
        "y" : 122
      },
      "type" : "ARROW",
      "empty" : true,
      "centre" : {
        "x" : 1393,
        "y" : 122
      }
    },
    "reactionShape" : {
      "a" : {
        "x" : 1391,
        "y" : 131
      },
      "b" : {
        "x" : 1403,
        "y" : 143
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 1397,
        "y" : 137
      }
    },
    "inputs" : [ {
      "id" : 38552
    } ],
    "outputs" : [ {
      "id" : 38603
    } ]
  } ],
  "shadows" : [ {
    "id" : 38649,
    "reactomeId" : 10099507,
    "displayName" : "Downstream signaling of activated FGFR1",
    "schemaClass" : "Pathway",
    "renderableClass" : "Shadow",
    "position" : {
      "x" : 3086,
      "y" : 521
    },
    "minX" : 1339,
    "maxX" : 4834,
    "minY" : 131,
    "maxY" : 912,
    "prop" : {
      "x" : 1339,
      "y" : 131,
      "width" : 3495,
      "height" : 188
    },
    "points" : [ {
      "x" : 1339,
      "y" : 131
    }, {
      "x" : 4834,
      "y" : 131
    }, {
      "x" : 4834,
      "y" : 912
    }, {
      "x" : 1339,
      "y" : 912
    } ],
    "colour" : "#4684ee"
  }, {
    "id" : 38650,
    "reactomeId" : 10099569,
    "displayName" : "FGFR1 ligand binding and activation",
    "schemaClass" : "Pathway",
    "renderableClass" : "Shadow",
    "position" : {
      "x" : 395,
      "y" : 1120
    },
    "minX" : -10,
    "maxX" : 800,
    "minY" : 381,
    "maxY" : 1859,
    "prop" : {
      "x" : -10,
      "y" : 381,
      "width" : 810,
      "height" : 1468
    },
    "points" : [ {
      "x" : -10,
      "y" : 381
    }, {
      "x" : 800,
      "y" : 381
    }, {
      "x" : 800,
      "y" : 1859
    }, {
      "x" : -10,
      "y" : 1859
    } ],
    "colour" : "#dc3912"
  }, {
    "id" : 38651,
    "reactomeId" : 10100521,
    "displayName" : "Negative regulation of FGFR1 signaling",
    "schemaClass" : "Pathway",
    "renderableClass" : "Shadow",
    "position" : {
      "x" : 4284,
      "y" : 1194
    },
    "minX" : 2325,
    "maxX" : 6243,
    "minY" : 319,
    "maxY" : 2069,
    "prop" : {
      "x" : 2325,
      "y" : 912,
      "width" : 3918,
      "height" : 1157
    },
    "points" : [ {
      "x" : 2325,
      "y" : 319
    }, {
      "x" : 6243,
      "y" : 319
    }, {
      "x" : 6243,
      "y" : 2069
    }, {
      "x" : 2325,
      "y" : 2069
    } ],
    "colour" : "#008000"
  }, {
    "id" : 38652,
    "reactomeId" : 10101251,
    "displayName" : "FGFRL1 modulation of FGFR1 signaling",
    "schemaClass" : "Pathway",
    "renderableClass" : "Shadow",
    "position" : {
      "x" : 679,
      "y" : 2005
    },
    "minX" : 30,
    "maxX" : 1329,
    "minY" : 1849,
    "maxY" : 2162,
    "prop" : {
      "x" : 30,
      "y" : 1859,
      "width" : 1299,
      "height" : 303
    },
    "points" : [ {
      "x" : 30,
      "y" : 1849
    }, {
      "x" : 1329,
      "y" : 1849
    }, {
      "x" : 1329,
      "y" : 2162
    }, {
      "x" : 30,
      "y" : 2162
    } ],
    "colour" : "#666666"
  } ],
  "minX" : 0,
  "maxX" : 6239,
  "minY" : 0,
  "maxY" : 2164,
  "disease" : false
}