{
  "dbId" : 10099393,
  "stableId" : "R-MMU-1181150",
  "displayName" : "Signaling by NODAL",
  "nodes" : [ {
    "id" : 69904,
    "reactomeId" : 9997684,
    "displayName" : "p-T,Y MAPK dimers",
    "schemaClass" : "DefinedSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 238,
      "y" : 342
    },
    "minX" : 195,
    "maxX" : 281,
    "minY" : 328,
    "maxY" : 383,
    "prop" : {
      "x" : 195,
      "y" : 328,
      "width" : 86,
      "height" : 29
    },
    "textPosition" : {
      "x" : 198,
      "y" : 325
    },
    "connectors" : [ {
      "edgeId" : 69902,
      "type" : "INHIBITOR",
      "segments" : [ {
        "from" : {
          "x" : 243,
          "y" : 363
        },
        "to" : {
          "x" : 252,
          "y" : 381
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 248,
          "y" : 383
        },
        "b" : {
          "x" : 256,
          "y" : 379
        },
        "c" : {
          "x" : 252,
          "y" : 381
        },
        "type" : "STOP",
        "centre" : {
          "x" : 252,
          "y" : 381
        }
      }
    } ]
  }, {
    "id" : 69907,
    "reactomeId" : 10003085,
    "displayName" : "Foxo3",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 395,
      "y" : 534
    },
    "minX" : 360,
    "maxX" : 536,
    "minY" : 516,
    "maxY" : 557,
    "prop" : {
      "x" : 360,
      "y" : 522,
      "width" : 70,
      "height" : 24
    },
    "textPosition" : {
      "x" : 372,
      "y" : 523
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 430,
          "y" : 522
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 430,
          "y" : 522
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 69905,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 433,
          "y" : 539
        },
        "to" : {
          "x" : 536,
          "y" : 557
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 69906,
    "reactomeId" : 1535904,
    "displayName" : "FoxO3a-binding Element",
    "schemaClass" : "OtherEntity",
    "renderableClass" : "Entity",
    "position" : {
      "x" : 415,
      "y" : 579
    },
    "minX" : 330,
    "maxX" : 536,
    "minY" : 557,
    "maxY" : 592,
    "prop" : {
      "x" : 330,
      "y" : 566,
      "width" : 171,
      "height" : 26
    },
    "textPosition" : {
      "x" : 336,
      "y" : 568
    },
    "connectors" : [ {
      "edgeId" : 69905,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 486,
          "y" : 563
        },
        "to" : {
          "x" : 536,
          "y" : 557
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 69908,
    "reactomeId" : 10033731,
    "displayName" : "SMAD2,3:SMAD4:FOXO3:FoxO3a-binding Element",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 737,
      "y" : 598
    },
    "minX" : 575,
    "maxX" : 906,
    "minY" : 579,
    "maxY" : 612,
    "prop" : {
      "x" : 575,
      "y" : 585,
      "width" : 325,
      "height" : 27
    },
    "textPosition" : {
      "x" : 583,
      "y" : 591
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 900,
          "y" : 585
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 900,
          "y" : 585
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 69905,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 69899,
    "reactomeId" : 9997497,
    "displayName" : "SMAD4",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 192,
      "y" : 389
    },
    "minX" : 148,
    "maxX" : 231,
    "minY" : 372,
    "maxY" : 414,
    "prop" : {
      "x" : 159,
      "y" : 378,
      "width" : 66,
      "height" : 23
    },
    "textPosition" : {
      "x" : 166,
      "y" : 379
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 225,
          "y" : 378
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 225,
          "y" : 378
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 69898,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 170,
          "y" : 404
        },
        "to" : {
          "x" : 148,
          "y" : 412
        }
      } ],
      "stoichiometry" : {
        "value" : 3,
        "shape" : {
          "a" : {
            "x" : 153,
            "y" : 402
          },
          "b" : {
            "x" : 165,
            "y" : 414
          },
          "type" : "BOX",
          "empty" : true,
          "centre" : {
            "x" : 159,
            "y" : 408
          }
        }
      }
    } ]
  }, {
    "id" : 69901,
    "reactomeId" : 9997509,
    "displayName" : "p-2S-SMAD2,3:SMAD4",
    "schemaClass" : "DefinedSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 149,
      "y" : 564
    },
    "minX" : 70,
    "maxX" : 229,
    "minY" : 553,
    "maxY" : 575,
    "prop" : {
      "x" : 70,
      "y" : 553,
      "width" : 159,
      "height" : 22
    },
    "textPosition" : {
      "x" : 78,
      "y" : 553
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "connectors" : [ {
      "edgeId" : 69898,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 69902,
      "type" : "INPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 69900,
    "reactomeId" : 9997501,
    "displayName" : "p-2S-SMAD2,3",
    "schemaClass" : "DefinedSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 137,
      "y" : 318
    },
    "minX" : 88,
    "maxX" : 187,
    "minY" : 306,
    "maxY" : 412,
    "prop" : {
      "x" : 88,
      "y" : 306,
      "width" : 99,
      "height" : 25
    },
    "textPosition" : {
      "x" : 90,
      "y" : 308
    },
    "connectors" : [ {
      "edgeId" : 69898,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 138,
          "y" : 337
        },
        "to" : {
          "x" : 148,
          "y" : 412
        }
      } ],
      "stoichiometry" : {
        "value" : 3,
        "shape" : {
          "a" : {
            "x" : 137,
            "y" : 368
          },
          "b" : {
            "x" : 149,
            "y" : 380
          },
          "type" : "BOX",
          "empty" : true,
          "centre" : {
            "x" : 143,
            "y" : 374
          }
        }
      }
    } ]
  }, {
    "id" : 69903,
    "reactomeId" : 9997647,
    "displayName" : "p-2S-SMAD2,3:SMAD4",
    "schemaClass" : "DefinedSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 482,
      "y" : 368
    },
    "minX" : 350,
    "maxX" : 561,
    "minY" : 356,
    "maxY" : 557,
    "prop" : {
      "x" : 404,
      "y" : 356,
      "width" : 157,
      "height" : 24
    },
    "textPosition" : {
      "x" : 411,
      "y" : 357
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "connectors" : [ {
      "edgeId" : 69905,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 416,
          "y" : 386
        },
        "to" : {
          "x" : 351,
          "y" : 392
        }
      }, {
        "from" : {
          "x" : 351,
          "y" : 392
        },
        "to" : {
          "x" : 350,
          "y" : 474
        }
      }, {
        "from" : {
          "x" : 350,
          "y" : 474
        },
        "to" : {
          "x" : 536,
          "y" : 557
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 69902,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  } ],
  "edges" : [ {
    "id" : 69905,
    "reactomeId" : 10033733,
    "displayName" : "Phospho R-SMAD(SMAD2/3):CO-SMAD(SMAD4):FOXO3 binds FoxO3a-binding elements",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 567,
      "y" : 557
    },
    "minX" : 536,
    "maxX" : 681,
    "minY" : 551,
    "maxY" : 582,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 536,
        "y" : 557
      },
      "to" : {
        "x" : 567,
        "y" : 557
      }
    }, {
      "from" : {
        "x" : 567,
        "y" : 557
      },
      "to" : {
        "x" : 681,
        "y" : 582
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 673,
        "y" : 584
      },
      "b" : {
        "x" : 681,
        "y" : 582
      },
      "c" : {
        "x" : 675,
        "y" : 577
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 675,
        "y" : 577
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 567,
        "y" : 557
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 567,
        "y" : 557
      }
    },
    "inputs" : [ {
      "id" : 69906,
      "points" : [ {
        "x" : 486,
        "y" : 563
      } ]
    }, {
      "id" : 69903,
      "points" : [ {
        "x" : 416,
        "y" : 386
      }, {
        "x" : 351,
        "y" : 392
      }, {
        "x" : 350,
        "y" : 474
      } ]
    }, {
      "id" : 69907,
      "points" : [ {
        "x" : 433,
        "y" : 539
      } ]
    } ],
    "outputs" : [ {
      "id" : 69908
    } ]
  }, {
    "id" : 69898,
    "reactomeId" : 9997511,
    "displayName" : "Phosphorylated SMAD2 and SMAD3 form a complex with SMAD4",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 141,
      "y" : 430
    },
    "minX" : 135,
    "maxX" : 148,
    "minY" : 412,
    "maxY" : 547,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 148,
        "y" : 412
      },
      "to" : {
        "x" : 141,
        "y" : 430
      }
    }, {
      "from" : {
        "x" : 141,
        "y" : 430
      },
      "to" : {
        "x" : 148,
        "y" : 547
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 144,
        "y" : 540
      },
      "b" : {
        "x" : 148,
        "y" : 547
      },
      "c" : {
        "x" : 152,
        "y" : 540
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 152,
        "y" : 540
      }
    },
    "reactionShape" : {
      "a" : {
        "x" : 135,
        "y" : 424
      },
      "b" : {
        "x" : 147,
        "y" : 436
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 141,
        "y" : 430
      }
    },
    "inputs" : [ {
      "id" : 69899,
      "points" : [ {
        "x" : 170,
        "y" : 404
      } ],
      "stoichiometry" : 3
    }, {
      "id" : 69900,
      "points" : [ {
        "x" : 138,
        "y" : 337
      } ],
      "stoichiometry" : 3
    } ],
    "outputs" : [ {
      "id" : 69901
    } ]
  }, {
    "id" : 69902,
    "reactomeId" : 9997686,
    "displayName" : "The SMAD2/3:SMAD4 complex transfers to the nucleus",
    "schemaClass" : "BlackBoxEvent",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 256,
      "y" : 389
    },
    "minX" : 155,
    "maxX" : 398,
    "minY" : 375,
    "maxY" : 547,
    "reactionType" : "omitted",
    "segments" : [ {
      "from" : {
        "x" : 155,
        "y" : 547
      },
      "to" : {
        "x" : 256,
        "y" : 389
      }
    }, {
      "from" : {
        "x" : 256,
        "y" : 389
      },
      "to" : {
        "x" : 398,
        "y" : 375
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 391,
        "y" : 380
      },
      "b" : {
        "x" : 398,
        "y" : 375
      },
      "c" : {
        "x" : 391,
        "y" : 372
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 391,
        "y" : 372
      }
    },
    "reactionShape" : {
      "a" : {
        "x" : 250,
        "y" : 383
      },
      "b" : {
        "x" : 262,
        "y" : 395
      },
      "s" : "\\\\",
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 256,
        "y" : 389
      }
    },
    "inputs" : [ {
      "id" : 69901
    } ],
    "outputs" : [ {
      "id" : 69903
    } ],
    "inhibitors" : [ {
      "id" : 69904,
      "points" : [ {
        "x" : 243,
        "y" : 363
      } ]
    } ]
  } ],
  "compartments" : [ {
    "id" : 69909,
    "reactomeId" : 70101,
    "displayName" : "cytosol",
    "schemaClass" : "Compartment",
    "renderableClass" : "Compartment",
    "position" : {
      "x" : 467,
      "y" : 331
    },
    "minX" : 0,
    "maxX" : 935,
    "minY" : 0,
    "maxY" : 663,
    "prop" : {
      "x" : 0,
      "y" : 0,
      "width" : 935,
      "height" : 663
    },
    "textPosition" : {
      "x" : 21,
      "y" : 617
    },
    "insets" : {
      "x" : 10,
      "y" : 10,
      "width" : 915,
      "height" : 643
    },
    "bgColor" : {
      "r" : 250,
      "g" : 240,
      "b" : 240
    },
    "componentIds" : [ 69910, 69900, 69898, 69899, 69901, 69902, 69904 ]
  }, {
    "id" : 69910,
    "reactomeId" : 7660,
    "displayName" : "nucleoplasm",
    "schemaClass" : "Compartment",
    "renderableClass" : "Compartment",
    "position" : {
      "x" : 608,
      "y" : 483
    },
    "minX" : 300,
    "maxX" : 916,
    "minY" : 328,
    "maxY" : 638,
    "prop" : {
      "x" : 300,
      "y" : 328,
      "width" : 616,
      "height" : 310
    },
    "textPosition" : {
      "x" : 313,
      "y" : 590
    },
    "insets" : {
      "x" : 310,
      "y" : 338,
      "width" : 596,
      "height" : 290
    },
    "bgColor" : {
      "r" : 250,
      "g" : 240,
      "b" : 240
    },
    "componentIds" : [ 69903, 69906, 69908, 69907, 69905 ]
  } ],
  "notes" : [ ],
  "links" : [ ],
  "shadows" : [ ],
  "minX" : 0,
  "maxX" : 935,
  "minY" : 0,
  "maxY" : 663,
  "disease" : false
}