{
  "dbId" : 10099383,
  "stId" : "R-MMU-170834",
  "speciesName" : "Mus musculus",
  "nodes" : [ {
    "dbId" : 9997465,
    "stId" : "R-MMU-177108",
    "displayName" : "Tgfb1 [Golgi lumen]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48892,
    "identifier" : "P04202",
    "standardIdentifier" : "uniprot:P04202",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "Tgfb1" ],
    "parents" : [ 9997467 ],
    "children" : [ ]
  }, {
    "dbId" : 10044314,
    "stId" : "R-MMU-2161391",
    "displayName" : "Ltbp1 [extracellular region]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48892,
    "identifier" : "Q8CG19",
    "standardIdentifier" : "uniprot:Q8CG19",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "Ltbp1" ],
    "parents" : [ 10044362, 10044360, 10044366, 10044328 ],
    "children" : [ ]
  }, {
    "dbId" : 9997467,
    "stId" : "R-MMU-177102",
    "displayName" : "TGFB1 homodimer [Golgi lumen]",
    "schemaClass" : "Complex",
    "speciesId" : 48892,
    "parents" : [ 9997471 ],
    "children" : [ 9997465 ]
  }, {
    "dbId" : 9997469,
    "stId" : "R-MMU-9736812",
    "displayName" : "Tgfb1 [Golgi lumen]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48892,
    "identifier" : "P04202",
    "standardIdentifier" : "uniprot:P04202",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "Tgfb1" ],
    "parents" : [ 9997471 ],
    "children" : [ ]
  }, {
    "dbId" : 10044318,
    "stId" : "R-MMU-2161309",
    "displayName" : "Ltbp4 [extracellular region]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48892,
    "diagramIds" : [ 120181 ],
    "identifier" : "Q8K4G1",
    "standardIdentifier" : "uniprot:Q8K4G1",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "Ltbp4" ],
    "parents" : [ 10044328, 10044388 ],
    "children" : [ ]
  }, {
    "dbId" : 9997471,
    "stId" : "R-MMU-9736811",
    "displayName" : "TGF-beta-1:LAP1 [Golgi lumen]",
    "schemaClass" : "Complex",
    "speciesId" : 48892,
    "diagramIds" : [ 120087 ],
    "parents" : [ ],
    "children" : [ 9997469, 9997467 ]
  }, {
    "dbId" : 9997456,
    "stId" : "R-MMU-170840",
    "displayName" : "TGFB1:TGFBR2:TGFBR1 [plasma membrane]",
    "schemaClass" : "Complex",
    "speciesId" : 48892,
    "diagramIds" : [ 120099 ],
    "parents" : [ ],
    "children" : [ 9997415, 9997454, 9997420 ]
  }, {
    "dbId" : 10026386,
    "stId" : "R-MMU-975970",
    "displayName" : "Stub1 [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48892,
    "diagramIds" : [ 120152 ],
    "identifier" : "Q9WUD1",
    "standardIdentifier" : "uniprot:Q9WUD1",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "Stub1" ],
    "parents" : [ 10043567 ],
    "children" : [ ]
  }, {
    "dbId" : 9997461,
    "stId" : "R-MMU-114705",
    "displayName" : "Tgfb1 [Golgi lumen]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48892,
    "identifier" : "P04202",
    "standardIdentifier" : "uniprot:P04202",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "Tgfb1" ],
    "parents" : [ 9997463 ],
    "children" : [ ]
  }, {
    "dbId" : 9997463,
    "stId" : "R-MMU-171260",
    "displayName" : "Pre-TGFB1 complex [Golgi lumen]",
    "schemaClass" : "Complex",
    "speciesId" : 48892,
    "diagramIds" : [ 120086 ],
    "parents" : [ ],
    "children" : [ 9997461 ]
  }, {
    "dbId" : 9997448,
    "stId" : "R-MMU-171266",
    "displayName" : "TGFB1:p-TGFBR:ZFYVE9:SMAD2/3 [early endosome membrane]",
    "schemaClass" : "Complex",
    "speciesId" : 48892,
    "diagramIds" : [ 120108 ],
    "parents" : [ ],
    "children" : [ 9997415, 9997446, 9997438, 9997420, 9997432 ]
  }, {
    "dbId" : 10006411,
    "stId" : "R-MMU-210013",
    "displayName" : "ITGAV(31-1048) [plasma membrane]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48892,
    "identifier" : "P43406",
    "standardIdentifier" : "uniprot:P43406",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "Itgav" ],
    "parents" : [ 10007230, 10007236, 10006413, 10007309, 10007315 ],
    "children" : [ ]
  }, {
    "dbId" : 9997452,
    "stId" : "R-MMU-170839",
    "displayName" : "TGFBR1 [plasma membrane]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48892,
    "identifier" : "Q64729",
    "standardIdentifier" : "uniprot:Q64729",
    "referenceType" : "ReferenceGeneProduct",
    "parents" : [ 9997477, 9997454 ],
    "children" : [ ]
  }, {
    "dbId" : 10006413,
    "stId" : "R-MMU-210216",
    "displayName" : "Integrin alphaVbeta3 [plasma membrane]",
    "schemaClass" : "Complex",
    "speciesId" : 48892,
    "parents" : [ 10044358, 10044512 ],
    "children" : [ 10006411, 9993049 ]
  }, {
    "dbId" : 9997454,
    "stId" : "R-MMU-170864",
    "displayName" : "TGFBR1 homodimer [plasma membrane]",
    "schemaClass" : "Complex",
    "speciesId" : 48892,
    "parents" : [ 9997456 ],
    "children" : [ 9997452 ]
  }, {
    "dbId" : 9997696,
    "stId" : "R-MMU-2176443",
    "displayName" : "Ub-SMAD2 [cytosol]",
    "schemaClass" : "Complex",
    "speciesId" : 48892,
    "diagramIds" : [ 120141 ],
    "parents" : [ ],
    "children" : [ 9997441, 9985374 ]
  }, {
    "dbId" : 2161209,
    "stId" : "R-MMU-2161209",
    "displayName" : "Smad7 [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48892,
    "diagramIds" : [ 120125 ],
    "identifier" : "O35253",
    "standardIdentifier" : "uniprot:O35253",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "Smad7", "Madh7", "Madh8" ],
    "parents" : [ 9997676, 10041909, 9997689 ],
    "children" : [ ]
  }, {
    "dbId" : 9997441,
    "stId" : "R-MMU-3006353",
    "displayName" : "SMAD2 [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48892,
    "diagramIds" : [ 120137 ],
    "identifier" : "Q62432",
    "standardIdentifier" : "uniprot:Q62432",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "Smad2", "Madh2", "Madr2" ],
    "parents" : [ 9997696, 9997694, 9997446 ],
    "children" : [ ]
  }, {
    "dbId" : 9997444,
    "stId" : "R-MMU-170855",
    "displayName" : "SMAD3 [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48892,
    "diagramIds" : [ 120151 ],
    "identifier" : "Q8BUN5",
    "standardIdentifier" : "uniprot:Q8BUN5",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "Smad3", "Madh3" ],
    "parents" : [ 10043569, 10043567, 9997446 ],
    "children" : [ ]
  }, {
    "dbId" : 9999492,
    "stId" : "R-MMU-2395236",
    "displayName" : "TGFB1:LAP1 [extracellular region]",
    "schemaClass" : "Complex",
    "speciesId" : 48892,
    "diagramIds" : [ 120090 ],
    "parents" : [ 10044362, 10044360, 10044378, 10044376, 10044388 ],
    "children" : [ 9997420, 976205 ]
  }, {
    "dbId" : 9997446,
    "stId" : "R-MMU-171172",
    "displayName" : "SMAD2,3 [cytosol]",
    "schemaClass" : "DefinedSet",
    "speciesId" : 48892,
    "diagramIds" : [ 120107 ],
    "parents" : [ 10043563, 9997448 ],
    "children" : [ 9997444, 9997441 ]
  }, {
    "dbId" : 10042553,
    "stId" : "R-MMU-2134529",
    "displayName" : "Tight Junction Complex:p-PARD6A:RHOA [cell junction]",
    "schemaClass" : "Complex",
    "speciesId" : 48892,
    "parents" : [ 10042555 ],
    "children" : [ 10042551, 10042535, 10042541, 10042539, 10042537 ]
  }, {
    "dbId" : 9997497,
    "stId" : "R-MMU-170862",
    "displayName" : "SMAD4 [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48892,
    "diagramIds" : [ 120174 ],
    "identifier" : "P97471",
    "standardIdentifier" : "uniprot:P97471",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "Smad4", "Dpc4", "Madh4" ],
    "parents" : [ 9997505, 9997507, 9997503 ],
    "children" : [ ]
  }, {
    "dbId" : 10042555,
    "stId" : "R-MMU-2134534",
    "displayName" : "Tight Junction Complex:TGFB1:TGFBR2:p-TGFBR1:p-PARD6A:RHOA [cell junction]",
    "schemaClass" : "Complex",
    "speciesId" : 48892,
    "diagramIds" : [ 120117 ],
    "parents" : [ 10042557 ],
    "children" : [ 9997434, 10042553 ]
  }, {
    "dbId" : 10007226,
    "stId" : "R-MMU-215943",
    "displayName" : "ITGA8(39-1063) [plasma membrane]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48892,
    "identifier" : "A2ARA8",
    "standardIdentifier" : "uniprot:A2ARA8",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "Itga8" ],
    "parents" : [ 10007228 ],
    "children" : [ ]
  }, {
    "dbId" : 9997499,
    "stId" : "R-MMU-3009186",
    "displayName" : "phospho-p-S465,S467-SMAD2 [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48892,
    "identifier" : "Q62432",
    "standardIdentifier" : "uniprot:Q62432",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "Smad2", "Madh2", "Madr2" ],
    "parents" : [ 9997501, 9997505, 9997503 ],
    "children" : [ ]
  }, {
    "dbId" : 10042557,
    "stId" : "R-MMU-2160929",
    "displayName" : "Tight Junction Complex:TGFB1:TGFBR2:p-TGFBR1:p-PARD6A:RHOA:SMURF1 [plasma membrane]",
    "schemaClass" : "Complex",
    "speciesId" : 48892,
    "diagramIds" : [ 120119 ],
    "parents" : [ 10042559 ],
    "children" : [ 10003659, 10042555 ]
  }, {
    "dbId" : 10007228,
    "stId" : "R-MMU-216012",
    "displayName" : "Integrin alpha8beta1 [plasma membrane]",
    "schemaClass" : "Complex",
    "speciesId" : 48892,
    "parents" : [ 10044358 ],
    "children" : [ 434908, 10007226 ]
  }, {
    "dbId" : 9997501,
    "stId" : "R-MMU-171182",
    "displayName" : "p-2S-SMAD2,3 [cytosol]",
    "schemaClass" : "DefinedSet",
    "speciesId" : 48892,
    "diagramIds" : [ 120114 ],
    "parents" : [ 10043557, 10043584, 9997513 ],
    "children" : [ 9605416, 9997499 ]
  }, {
    "dbId" : 10042559,
    "stId" : "R-MMU-2160934",
    "displayName" : "Tight Junction Complex:TGFB1:TGFBR2:p-TGFBR1:p-PARD6A:Ub-RHOA:SMURF1 [cell junction]",
    "schemaClass" : "Complex",
    "speciesId" : 48892,
    "diagramIds" : [ 120122 ],
    "parents" : [ ],
    "children" : [ 9985374, 10042557 ]
  }, {
    "dbId" : 10007230,
    "stId" : "R-MMU-216015",
    "displayName" : "Integrin alphaVbeta1 [plasma membrane]",
    "schemaClass" : "Complex",
    "speciesId" : 48892,
    "parents" : [ 10044358, 10044512 ],
    "children" : [ 434908, 10006411 ]
  }, {
    "dbId" : 10099389,
    "stId" : "R-MMU-2173793",
    "displayName" : "Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer",
    "schemaClass" : "Pathway",
    "speciesId" : 48892,
    "diagramIds" : [ 120200 ]
  }, {
    "dbId" : 10043582,
    "stId" : "R-MMU-2187404",
    "displayName" : "MTMR4 [early endosome membrane]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48892,
    "diagramIds" : [ 120158 ],
    "identifier" : "Q91XS1",
    "standardIdentifier" : "uniprot:Q91XS1",
    "referenceType" : "ReferenceGeneProduct",
    "parents" : [ 10043584 ],
    "children" : [ ]
  }, {
    "dbId" : 9997503,
    "stId" : "R-MMU-206866",
    "displayName" : "p-2S-SMAD2:p-2S-SMAD2:SMAD4 [cytosol]",
    "schemaClass" : "Complex",
    "speciesId" : 48892,
    "parents" : [ 9997509 ],
    "children" : [ 9997499, 9997497 ]
  }, {
    "dbId" : 10043569,
    "stId" : "R-MMU-2187371",
    "displayName" : "Ub-SMAD3 [cytosol]",
    "schemaClass" : "Complex",
    "speciesId" : 48892,
    "diagramIds" : [ 120155 ],
    "parents" : [ ],
    "children" : [ 9997444, 9985374 ]
  }, {
    "dbId" : 9997489,
    "stId" : "R-MMU-9839342",
    "displayName" : "TGFB1,TGFB2:TGFBR3 [plasma membrane]",
    "schemaClass" : "Complex",
    "speciesId" : 48892,
    "parents" : [ 9997491 ],
    "children" : [ 9997487, 9997481 ]
  }, {
    "dbId" : 10042547,
    "stId" : "R-MMU-2134483",
    "displayName" : "PRKCZ [cell junction]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48892,
    "identifier" : "Q02956",
    "standardIdentifier" : "uniprot:Q02956",
    "referenceType" : "ReferenceGeneProduct",
    "parents" : [ 10042551 ],
    "children" : [ ]
  }, {
    "dbId" : 9997491,
    "stId" : "R-MMU-9839341",
    "displayName" : "TGFB1,TGFB2:TGFBR3:TGFBR2 [plasma membrane]",
    "schemaClass" : "Complex",
    "speciesId" : 48892,
    "diagramIds" : [ 120095 ],
    "parents" : [ ],
    "children" : [ 9997413, 9997489 ]
  }, {
    "dbId" : 10042549,
    "stId" : "R-MMU-2134533",
    "displayName" : "phospho-Pard6a [plasma membrane]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48892,
    "identifier" : "Q9Z101",
    "standardIdentifier" : "uniprot:Q9Z101",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "Pard6a", "Par6a" ],
    "parents" : [ 10042551 ],
    "children" : [ ]
  }, {
    "dbId" : 10042551,
    "stId" : "R-MMU-2134528",
    "displayName" : "PARD3:p-PARD6A:PRKCZ [cell junction]",
    "schemaClass" : "Complex",
    "speciesId" : 48892,
    "parents" : [ 10042553 ],
    "children" : [ 10042549, 10042547, 10042543 ]
  }, {
    "dbId" : 10042537,
    "stId" : "R-MMU-2134498",
    "displayName" : "F11r [cell junction]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48892,
    "identifier" : "O88792",
    "standardIdentifier" : "uniprot:O88792",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "F11r" ],
    "parents" : [ 10042553 ],
    "children" : [ ]
  }, {
    "dbId" : 10043561,
    "stId" : "R-MMU-2186792",
    "displayName" : "Pmepa1 [plasma membrane]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48892,
    "diagramIds" : [ 120148 ],
    "identifier" : "Q9D7R2",
    "standardIdentifier" : "uniprot:Q9D7R2",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "Pmepa1" ],
    "parents" : [ 10043563 ],
    "children" : [ ]
  }, {
    "dbId" : 9997481,
    "stId" : "R-MMU-9839336",
    "displayName" : "Tgfbr3 [plasma membrane]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48892,
    "identifier" : "O88393",
    "standardIdentifier" : "uniprot:O88393",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "Tgfbr3" ],
    "parents" : [ 9997489 ],
    "children" : [ ]
  }, {
    "dbId" : 10044328,
    "stId" : "R-MMU-2396175",
    "displayName" : "LTBPs [extracellular region]",
    "schemaClass" : "CandidateSet",
    "speciesId" : 48892,
    "diagramIds" : [ 120193 ],
    "parents" : [ 10044330 ],
    "children" : [ 10044318, 10044314, 10044326, 10044322 ]
  }, {
    "dbId" : 10042539,
    "stId" : "R-MMU-2134503",
    "displayName" : "RHOA [cell junction]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48892,
    "identifier" : "Q9QUI0",
    "standardIdentifier" : "uniprot:Q9QUI0",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "Rhoa", "Arha", "Arha2" ],
    "parents" : [ 10042553 ],
    "children" : [ ]
  }, {
    "dbId" : 10043563,
    "stId" : "R-MMU-2187341",
    "displayName" : "SMAD2/3:PMEPA1 [plasma membrane]",
    "schemaClass" : "Complex",
    "speciesId" : 48892,
    "diagramIds" : [ 120149 ],
    "parents" : [ ],
    "children" : [ 9997446, 10043561 ]
  }, {
    "dbId" : 10044330,
    "stId" : "R-MMU-2396177",
    "displayName" : "LTBPs:Fibrillin-1 [extracellular region]",
    "schemaClass" : "Complex",
    "speciesId" : 48892,
    "diagramIds" : [ 120194 ],
    "parents" : [ ],
    "children" : [ 10034558, 10044328 ]
  }, {
    "dbId" : 10042541,
    "stId" : "R-MMU-2134486",
    "displayName" : "Arhgef18 [cell junction]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48892,
    "identifier" : "Q6P9R4",
    "standardIdentifier" : "uniprot:Q6P9R4",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "Arhgef18" ],
    "parents" : [ 10042553 ],
    "children" : [ ]
  }, {
    "dbId" : 10043309,
    "stId" : "R-MMU-2169047",
    "displayName" : "TGFB1:TGFBR2:Ub-p-TGFBR1:Ub-SMAD7 [plasma membrane]",
    "schemaClass" : "Complex",
    "speciesId" : 48892,
    "diagramIds" : [ 120135 ],
    "parents" : [ ],
    "children" : [ 9985374, 9997689 ]
  }, {
    "dbId" : 9997485,
    "stId" : "R-MMU-114706",
    "displayName" : "Tgfb2 [extracellular region]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48892,
    "identifier" : "P27090",
    "standardIdentifier" : "uniprot:P27090",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "Tgfb2" ],
    "parents" : [ 10044370, 9997487 ],
    "children" : [ ]
  }, {
    "dbId" : 10042543,
    "stId" : "R-MMU-2134481",
    "displayName" : "Pard3 [cell junction]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48892,
    "identifier" : "Q99NH2",
    "standardIdentifier" : "uniprot:Q99NH2",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "Pard3" ],
    "parents" : [ 10042551 ],
    "children" : [ ]
  }, {
    "dbId" : 10043567,
    "stId" : "R-MMU-2187365",
    "displayName" : "SMAD3:STUB1 [cytosol]",
    "schemaClass" : "Complex",
    "speciesId" : 48892,
    "diagramIds" : [ 120153 ],
    "parents" : [ ],
    "children" : [ 9997444, 10026386 ]
  }, {
    "dbId" : 9997487,
    "stId" : "R-MMU-9839339",
    "displayName" : "TGFB1,TGFB2 [extracellular region]",
    "schemaClass" : "DefinedSet",
    "speciesId" : 48892,
    "parents" : [ 9997521, 9997489 ],
    "children" : [ 9997485, 9997418 ]
  }, {
    "dbId" : 10043555,
    "stId" : "R-MMU-2187347",
    "displayName" : "Pmepa1 [early endosome membrane]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48892,
    "diagramIds" : [ 120145 ],
    "identifier" : "Q9D7R2",
    "standardIdentifier" : "uniprot:Q9D7R2",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "Pmepa1" ],
    "parents" : [ 10043557 ],
    "children" : [ ]
  }, {
    "dbId" : 9997475,
    "stId" : "R-MMU-170865",
    "displayName" : "Dimeric TGFB1:TGFBR2 homodimer [plasma membrane]",
    "schemaClass" : "Complex",
    "speciesId" : 48892,
    "diagramIds" : [ 120094 ],
    "parents" : [ ],
    "children" : [ 9997415, 9997420 ]
  }, {
    "dbId" : 10044322,
    "stId" : "R-MMU-2161340",
    "displayName" : "LTBP2 [extracellular region]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48892,
    "identifier" : "O08999",
    "standardIdentifier" : "uniprot:O08999",
    "referenceType" : "ReferenceGeneProduct",
    "parents" : [ 10044328 ],
    "children" : [ ]
  }, {
    "dbId" : 10043557,
    "stId" : "R-MMU-2187343",
    "displayName" : "p-2S-SMAD2/3:PMEPA1 [early endosome membrane]",
    "schemaClass" : "Complex",
    "speciesId" : 48892,
    "diagramIds" : [ 120146 ],
    "parents" : [ ],
    "children" : [ 10043555, 9997501 ]
  }, {
    "dbId" : 9997477,
    "stId" : "R-MMU-2187279",
    "displayName" : "TGFBR1:FKBP1A [plasma membrane]",
    "schemaClass" : "Complex",
    "speciesId" : 48892,
    "diagramIds" : [ 120098 ],
    "parents" : [ ],
    "children" : [ 9996339, 9997452 ]
  }, {
    "dbId" : 10042535,
    "stId" : "R-MMU-2134478",
    "displayName" : "Cgn [cell junction]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48892,
    "identifier" : "P59242",
    "standardIdentifier" : "uniprot:P59242",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "Cgn" ],
    "parents" : [ 10042553 ],
    "children" : [ ]
  }, {
    "dbId" : 10044326,
    "stId" : "R-MMU-2161253",
    "displayName" : "Ltbp3 [extracellular region]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48892,
    "identifier" : "Q61810",
    "standardIdentifier" : "uniprot:Q61810",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "Ltbp3" ],
    "parents" : [ 10044366, 10044328 ],
    "children" : [ ]
  }, {
    "dbId" : 9999832,
    "stId" : "R-MMU-2167870",
    "displayName" : "SMAD7:SMURF2 [nucleoplasm]",
    "schemaClass" : "Complex",
    "speciesId" : 48892,
    "diagramIds" : [ 120133 ],
    "parents" : [ ],
    "children" : [ 9999830, 2167887 ]
  }, {
    "dbId" : 10044376,
    "stId" : "R-MMU-2395330",
    "displayName" : "TGFB:LAP [extracellular region]",
    "schemaClass" : "DefinedSet",
    "speciesId" : 48892,
    "diagramIds" : [ 120177 ],
    "parents" : [ ],
    "children" : [ 10044374, 9999492, 10044370 ]
  }, {
    "dbId" : 940364,
    "stId" : "R-MMU-940364",
    "displayName" : "Ubiquitin (Ubb 1) [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48892,
    "identifier" : "P0CG49",
    "standardIdentifier" : "uniprot:P0CG49",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "Ubb" ],
    "parents" : [ 9985374 ],
    "children" : [ ]
  }, {
    "dbId" : 940365,
    "stId" : "R-MMU-940365",
    "displayName" : "Ubiquitin (Uba52) [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48892,
    "identifier" : "P62984",
    "standardIdentifier" : "uniprot:P62984",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "Uba52", "Ubcep2" ],
    "parents" : [ 9985374 ],
    "children" : [ ]
  }, {
    "dbId" : 976205,
    "stId" : "R-MMU-976205",
    "displayName" : "Tgfb1 [extracellular region]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48892,
    "identifier" : "P04202",
    "standardIdentifier" : "uniprot:P04202",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "Tgfb1" ],
    "parents" : [ 9999492 ],
    "children" : [ ]
  }, {
    "dbId" : 10044378,
    "stId" : "R-MMU-9736824",
    "displayName" : "LTBP1,LTBP3:TGFB1:LAP1 [extracellular region]",
    "schemaClass" : "Complex",
    "speciesId" : 48892,
    "parents" : [ 10044384 ],
    "children" : [ 9999492, 10044366 ]
  }, {
    "dbId" : 940362,
    "stId" : "R-MMU-940362",
    "displayName" : "Ubiquitin (Ubc 3) [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48892,
    "identifier" : "P0CG50",
    "standardIdentifier" : "uniprot:P0CG50",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "Ubc" ],
    "parents" : [ 9985374 ],
    "children" : [ ]
  }, {
    "dbId" : 10044380,
    "stId" : "R-MMU-9736823",
    "displayName" : "LTBP1,LTBP3:TGFB2:LAP2 [extracellular region]",
    "schemaClass" : "Complex",
    "speciesId" : 48892,
    "parents" : [ 10044384 ],
    "children" : [ 10044370, 10044366 ]
  }, {
    "dbId" : 940360,
    "stId" : "R-MMU-940360",
    "displayName" : "Ubiquitin (Ubc 5) [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48892,
    "identifier" : "P0CG50",
    "standardIdentifier" : "uniprot:P0CG50",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "Ubc" ],
    "parents" : [ 9985374 ],
    "children" : [ ]
  }, {
    "dbId" : 10044382,
    "stId" : "R-MMU-9736822",
    "displayName" : "LTBP1,LTBP3:TGFB3:LAP3 [extracellular region]",
    "schemaClass" : "Complex",
    "speciesId" : 48892,
    "parents" : [ 10044384 ],
    "children" : [ 10044374, 10044366 ]
  }, {
    "dbId" : 940359,
    "stId" : "R-MMU-940359",
    "displayName" : "Ubiquitin (Ubc 4) [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48892,
    "identifier" : "P0CG50",
    "standardIdentifier" : "uniprot:P0CG50",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "Ubc" ],
    "parents" : [ 9985374 ],
    "children" : [ ]
  }, {
    "dbId" : 9997521,
    "stId" : "R-MMU-9839334",
    "displayName" : "TGFBR3(1-783):TGFB1,TGFB2 [extracellular region]",
    "schemaClass" : "Complex",
    "speciesId" : 48892,
    "diagramIds" : [ 120096 ],
    "parents" : [ ],
    "children" : [ 9997487, 9997519 ]
  }, {
    "dbId" : 10044368,
    "stId" : "R-MMU-2395269",
    "displayName" : "Tgfb2 [extracellular region]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48892,
    "identifier" : "P27090",
    "standardIdentifier" : "uniprot:P27090",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "Tgfb2" ],
    "parents" : [ 10044370 ],
    "children" : [ ]
  }, {
    "dbId" : 10044370,
    "stId" : "R-MMU-2395253",
    "displayName" : "TGFB2:LAP2 [extracellular region]",
    "schemaClass" : "Complex",
    "speciesId" : 48892,
    "parents" : [ 10044380, 10044376 ],
    "children" : [ 10044368, 9997485 ]
  }, {
    "dbId" : 10044372,
    "stId" : "R-MMU-2395290",
    "displayName" : "Tgfb3 [extracellular region]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48892,
    "identifier" : "P17125",
    "standardIdentifier" : "uniprot:P17125",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "Tgfb3" ],
    "parents" : [ 10044374 ],
    "children" : [ ]
  }, {
    "dbId" : 9999830,
    "stId" : "R-MMU-178202",
    "displayName" : "Smurf2 [nucleoplasm]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48892,
    "diagramIds" : [ 120132 ],
    "identifier" : "A2A5Z6",
    "standardIdentifier" : "uniprot:A2A5Z6",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "Smurf2" ],
    "parents" : [ 9999832 ],
    "children" : [ ]
  }, {
    "dbId" : 10044374,
    "stId" : "R-MMU-2395241",
    "displayName" : "TGFB3:LAP3 [extracellular region]",
    "schemaClass" : "Complex",
    "speciesId" : 48892,
    "diagramIds" : [ 120189 ],
    "parents" : [ 10044514, 10044382, 10044376 ],
    "children" : [ 10044372, 10019583 ]
  }, {
    "dbId" : 940382,
    "stId" : "R-MMU-940382",
    "displayName" : "Ubiquitin (Ubc 1) [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48892,
    "identifier" : "P0CG50",
    "standardIdentifier" : "uniprot:P0CG50",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "Ubc" ],
    "parents" : [ 9985374 ],
    "children" : [ ]
  }, {
    "dbId" : 9997513,
    "stId" : "R-MMU-171180",
    "displayName" : "TGFB1:p-TGFBR:ZFYVE9:p-2S-SMAD2,3 [early endosome membrane]",
    "schemaClass" : "Complex",
    "speciesId" : 48892,
    "diagramIds" : [ 120111 ],
    "parents" : [ ],
    "children" : [ 9997415, 9997438, 9997501, 9997420, 9997432 ]
  }, {
    "dbId" : 10044360,
    "stId" : "R-MMU-9737594",
    "displayName" : "LTBP1:TGFB1:LAP1 [extracellular region]",
    "schemaClass" : "Complex",
    "speciesId" : 48892,
    "diagramIds" : [ 120185 ],
    "parents" : [ ],
    "children" : [ 9999492, 10044314 ]
  }, {
    "dbId" : 10003659,
    "stId" : "R-MMU-975972",
    "displayName" : "Smurf1 [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48892,
    "diagramIds" : [ 120118 ],
    "identifier" : "Q9CUN6",
    "standardIdentifier" : "uniprot:Q9CUN6",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "Smurf1" ],
    "parents" : [ 10042557 ],
    "children" : [ ]
  }, {
    "dbId" : 10044362,
    "stId" : "R-MMU-2396201",
    "displayName" : "LTBP1:TGFB1:LAP1:LAP1-binding integrins [plasma membrane]",
    "schemaClass" : "Complex",
    "speciesId" : 48892,
    "diagramIds" : [ 120186 ],
    "parents" : [ ],
    "children" : [ 10044358, 9999492, 10044314 ]
  }, {
    "dbId" : 9997515,
    "stId" : "R-MMU-171173",
    "displayName" : "TGFB1:p-TGFBR:ZFYVE9 [early endosome membrane]",
    "schemaClass" : "Complex",
    "speciesId" : 48892,
    "diagramIds" : [ 120115 ],
    "parents" : [ ],
    "children" : [ 9997415, 9997438, 9997420, 9997432 ]
  }, {
    "dbId" : 940379,
    "stId" : "R-MMU-940379",
    "displayName" : "Ubiquitin (Ubc 8) [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48892,
    "identifier" : "P0CG50",
    "standardIdentifier" : "uniprot:P0CG50",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "Ubc" ],
    "parents" : [ 9985374 ],
    "children" : [ ]
  }, {
    "dbId" : 9997519,
    "stId" : "R-MMU-9839335",
    "displayName" : "Tgfbr3 [extracellular region]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48892,
    "identifier" : "O88393",
    "standardIdentifier" : "uniprot:O88393",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "Tgfbr3" ],
    "parents" : [ 9997521 ],
    "children" : [ ]
  }, {
    "dbId" : 10044366,
    "stId" : "R-MMU-2395372",
    "displayName" : "LTBP1, LTBP3 [extracellular region]",
    "schemaClass" : "DefinedSet",
    "speciesId" : 48892,
    "diagramIds" : [ 120178 ],
    "parents" : [ 10044378, 10044380, 10044382 ],
    "children" : [ 10044326, 10044314 ]
  }, {
    "dbId" : 10043584,
    "stId" : "R-MMU-2187399",
    "displayName" : "p-2S-SMAD2/3:MTMR4 [early endosome membrane]",
    "schemaClass" : "Complex",
    "speciesId" : 48892,
    "diagramIds" : [ 120159 ],
    "parents" : [ ],
    "children" : [ 10043582, 9997501 ]
  }, {
    "dbId" : 9997505,
    "stId" : "R-MMU-9736926",
    "displayName" : "p-2S-SMAD2:p-2S-SMAD3:SMAD4 [cytosol]",
    "schemaClass" : "Complex",
    "speciesId" : 48892,
    "parents" : [ 9997509 ],
    "children" : [ 9605416, 9997499, 9997497 ]
  }, {
    "dbId" : 10007234,
    "stId" : "R-MMU-215951",
    "displayName" : "ITGB6 [plasma membrane]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48892,
    "identifier" : "Q9Z0T9",
    "standardIdentifier" : "uniprot:Q9Z0T9",
    "referenceType" : "ReferenceGeneProduct",
    "parents" : [ 10007236 ],
    "children" : [ ]
  }, {
    "dbId" : 9997507,
    "stId" : "R-MMU-9736931",
    "displayName" : "p-2S-SMAD3:p-2S-SMAD3:SMAD4 [cytosol]",
    "schemaClass" : "Complex",
    "speciesId" : 48892,
    "parents" : [ 9997509 ],
    "children" : [ 9605416, 9997497 ]
  }, {
    "dbId" : 940370,
    "stId" : "R-MMU-940370",
    "displayName" : "Ubiquitin (Pps27a) [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48892,
    "identifier" : "P62983",
    "standardIdentifier" : "uniprot:P62983",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "Rps27a", "Uba80", "Ubcep1" ],
    "parents" : [ 9985374 ],
    "children" : [ ]
  }, {
    "dbId" : 10007236,
    "stId" : "R-MMU-216024",
    "displayName" : "Integrin alphaVbeta6 [plasma membrane]",
    "schemaClass" : "Complex",
    "speciesId" : 48892,
    "parents" : [ 10044358, 10044512 ],
    "children" : [ 10007234, 10006411 ]
  }, {
    "dbId" : 940371,
    "stId" : "R-MMU-940371",
    "displayName" : "Ubiquitin (Ubc 7) [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48892,
    "identifier" : "P0CG50",
    "standardIdentifier" : "uniprot:P0CG50",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "Ubc" ],
    "parents" : [ 9985374 ],
    "children" : [ ]
  }, {
    "dbId" : 9997509,
    "stId" : "R-MMU-171175",
    "displayName" : "p-2S-SMAD2,3:SMAD4 [cytosol]",
    "schemaClass" : "DefinedSet",
    "speciesId" : 48892,
    "diagramIds" : [ 120175 ],
    "parents" : [ ],
    "children" : [ 9997507, 9997505, 9997503 ]
  }, {
    "dbId" : 10044358,
    "stId" : "R-MMU-2396176",
    "displayName" : "LAP1 binding-integrins [plasma membrane]",
    "schemaClass" : "DefinedSet",
    "speciesId" : 48892,
    "diagramIds" : [ 120184 ],
    "parents" : [ 10044362 ],
    "children" : [ 10007236, 10007315, 10007230, 10007309, 10006413, 10007228 ]
  }, {
    "dbId" : 10019583,
    "stId" : "R-MMU-114707",
    "displayName" : "Tgfb3 [extracellular region]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48892,
    "identifier" : "P17125",
    "standardIdentifier" : "uniprot:P17125",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "Tgfb3" ],
    "parents" : [ 10044374 ],
    "children" : [ ]
  }, {
    "dbId" : 940388,
    "stId" : "R-MMU-940388",
    "displayName" : "Ubiquitin (Ubc 2) [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48892,
    "identifier" : "P0CG50",
    "standardIdentifier" : "uniprot:P0CG50",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "Ubc" ],
    "parents" : [ 9985374 ],
    "children" : [ ]
  }, {
    "dbId" : 940386,
    "stId" : "R-MMU-940386",
    "displayName" : "Ubiquitin related 1 (Ubc r1) [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48892,
    "identifier" : "P0CG50",
    "standardIdentifier" : "uniprot:P0CG50",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "Ubc" ],
    "parents" : [ 9985374 ],
    "children" : [ ]
  }, {
    "dbId" : 940384,
    "stId" : "R-MMU-940384",
    "displayName" : "Ubiquitin (Ubc 6) [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48892,
    "identifier" : "P0CG50",
    "standardIdentifier" : "uniprot:P0CG50",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "Ubc" ],
    "parents" : [ 9985374 ],
    "children" : [ ]
  }, {
    "dbId" : 2167887,
    "stId" : "R-MMU-2167887",
    "displayName" : "Smad7 [nucleoplasm]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48892,
    "diagramIds" : [ 120131 ],
    "identifier" : "O35253",
    "standardIdentifier" : "uniprot:O35253",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "Smad7", "Madh7", "Madh8" ],
    "parents" : [ 9999832 ],
    "children" : [ ]
  }, {
    "dbId" : 2128980,
    "stId" : "R-MMU-2128980",
    "displayName" : "Strap [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48892,
    "identifier" : "Q9Z1Z2",
    "standardIdentifier" : "uniprot:Q9Z1Z2",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "Strap", "Unrip" ],
    "parents" : [ 10041907 ],
    "children" : [ ]
  }, {
    "dbId" : 10044384,
    "stId" : "R-MMU-2395250",
    "displayName" : "LTBP1,LTBP3:TGFB:LAP [extracellular region]",
    "schemaClass" : "DefinedSet",
    "speciesId" : 48892,
    "diagramIds" : [ 120179 ],
    "parents" : [ ],
    "children" : [ 10044382, 10044380, 10044378 ]
  }, {
    "dbId" : 10044388,
    "stId" : "R-MMU-2395326",
    "displayName" : "LTBP4:TGFB1:LAP1 [extracellular region]",
    "schemaClass" : "Complex",
    "speciesId" : 48892,
    "diagramIds" : [ 120182 ],
    "parents" : [ ],
    "children" : [ 9999492, 10044318 ]
  }, {
    "dbId" : 5632468,
    "stId" : "R-MMU-5632468",
    "displayName" : "Smurf2 [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48892,
    "diagramIds" : [ 120138 ],
    "identifier" : "A2A5Z6",
    "standardIdentifier" : "uniprot:A2A5Z6",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "Smurf2" ],
    "parents" : [ 9997694 ],
    "children" : [ ]
  }, {
    "dbId" : 10007313,
    "stId" : "R-MMU-216318",
    "displayName" : "ITGB8 [plasma membrane]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48892,
    "identifier" : "Q0VBD0",
    "standardIdentifier" : "uniprot:Q0VBD0",
    "referenceType" : "ReferenceGeneProduct",
    "parents" : [ 10007315 ],
    "children" : [ ]
  }, {
    "dbId" : 10007315,
    "stId" : "R-MMU-216307",
    "displayName" : "Integrin alphaVbeta8 [plasma membrane]",
    "schemaClass" : "Complex",
    "speciesId" : 48892,
    "parents" : [ 10044358, 10044512 ],
    "children" : [ 10007313, 10006411 ]
  }, {
    "dbId" : 9999882,
    "stId" : "R-MMU-112199",
    "displayName" : "CBL [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48892,
    "diagramIds" : [ 120167 ],
    "identifier" : "P22682",
    "standardIdentifier" : "uniprot:P22682",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "Cbl" ],
    "parents" : [ 10050621 ],
    "children" : [ ]
  }, {
    "dbId" : 10007307,
    "stId" : "R-MMU-215948",
    "displayName" : "ITGB5 [plasma membrane]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48892,
    "identifier" : "O70309",
    "standardIdentifier" : "uniprot:O70309",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "Itgb5" ],
    "parents" : [ 10007309 ],
    "children" : [ ]
  }, {
    "dbId" : 10007309,
    "stId" : "R-MMU-1299497",
    "displayName" : "Integrin alphaVbeta5 [plasma membrane]",
    "schemaClass" : "Complex",
    "speciesId" : 48892,
    "parents" : [ 10044358, 10044512 ],
    "children" : [ 10007307, 10006411 ]
  }, {
    "dbId" : 10050621,
    "stId" : "R-MMU-4332229",
    "displayName" : "TGFBR2:CBL [plasma membrane]",
    "schemaClass" : "Complex",
    "speciesId" : 48892,
    "diagramIds" : [ 120168 ],
    "parents" : [ ],
    "children" : [ 9997413, 9999882 ]
  }, {
    "dbId" : 10041907,
    "stId" : "R-MMU-2127564",
    "displayName" : "TGFB1:p-TGFBR:STRAP [plasma membrane]",
    "schemaClass" : "Complex",
    "speciesId" : 48892,
    "diagramIds" : [ 120128 ],
    "parents" : [ 10041909 ],
    "children" : [ 2128980, 9997434 ]
  }, {
    "dbId" : 9996339,
    "stId" : "R-MMU-2026007",
    "displayName" : "Fkbp1a [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48892,
    "diagramIds" : [ 120100 ],
    "identifier" : "P26883",
    "standardIdentifier" : "uniprot:P26883",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "Fkbp1a" ],
    "parents" : [ 9997477 ],
    "children" : [ ]
  }, {
    "dbId" : 10041909,
    "stId" : "R-MMU-2128993",
    "displayName" : "TGFB1: p-TGFBR: STRAP: SMAD7 [plasma membrane]",
    "schemaClass" : "Complex",
    "speciesId" : 48892,
    "diagramIds" : [ 120129 ],
    "parents" : [ ],
    "children" : [ 10041907, 2161209 ]
  }, {
    "dbId" : 29356,
    "stId" : "R-ALL-29356",
    "displayName" : "H2O [cytosol]",
    "schemaClass" : "SimpleEntity",
    "speciesId" : 0,
    "diagramIds" : [ 120161 ],
    "identifier" : "15377",
    "standardIdentifier" : "chebi:15377",
    "referenceType" : "ReferenceMolecule",
    "parents" : [ ],
    "children" : [ ]
  }, {
    "dbId" : 113592,
    "stId" : "R-ALL-113592",
    "displayName" : "ATP [cytosol]",
    "schemaClass" : "SimpleEntity",
    "speciesId" : 0,
    "diagramIds" : [ 120102, 120110 ],
    "identifier" : "30616",
    "standardIdentifier" : "chebi:30616",
    "referenceType" : "ReferenceMolecule",
    "parents" : [ ],
    "children" : [ ]
  }, {
    "dbId" : 29370,
    "stId" : "R-ALL-29370",
    "displayName" : "ADP [cytosol]",
    "schemaClass" : "SimpleEntity",
    "speciesId" : 0,
    "diagramIds" : [ 120112, 120104 ],
    "identifier" : "456216",
    "standardIdentifier" : "chebi:456216",
    "referenceType" : "ReferenceMolecule",
    "parents" : [ ],
    "children" : [ ]
  }, {
    "dbId" : 9605416,
    "stId" : "R-MMU-9605416",
    "displayName" : "p-S423,425-Smad3 [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48892,
    "identifier" : "Q8BUN5",
    "standardIdentifier" : "uniprot:Q8BUN5",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "Smad3", "Madh3" ],
    "parents" : [ 9997501, 9997505, 9997507 ],
    "children" : [ ]
  }, {
    "dbId" : 29372,
    "stId" : "R-ALL-29372",
    "displayName" : "Pi [cytosol]",
    "schemaClass" : "SimpleEntity",
    "speciesId" : 0,
    "diagramIds" : [ 120162 ],
    "identifier" : "43474",
    "standardIdentifier" : "chebi:43474",
    "referenceType" : "ReferenceMolecule",
    "parents" : [ ],
    "children" : [ ]
  }, {
    "dbId" : 9993049,
    "stId" : "R-MMU-57600",
    "displayName" : "ITGB3 [plasma membrane]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48892,
    "identifier" : "O54890",
    "standardIdentifier" : "uniprot:O54890",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "Itgb3" ],
    "parents" : [ 10006413 ],
    "children" : [ ]
  }, {
    "dbId" : 9985370,
    "stId" : "R-MMU-939213",
    "displayName" : "Rps27a [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48892,
    "identifier" : "P62983",
    "standardIdentifier" : "uniprot:P62983",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "Rps27a", "Uba80", "Ubcep1" ],
    "parents" : [ 9985374 ],
    "children" : [ ]
  }, {
    "dbId" : 9985374,
    "stId" : "R-MMU-113595",
    "displayName" : "Ub [cytosol]",
    "schemaClass" : "DefinedSet",
    "speciesId" : 48892,
    "diagramIds" : [ 120121, 120143 ],
    "parents" : [ 10042559, 10043309, 9997696, 10043569 ],
    "children" : [ 940364, 9985370, 940365, 940362, 940360, 940359, 940388, 940386, 940384, 940382, 940379, 940370, 940371 ]
  }, {
    "dbId" : 10050640,
    "stId" : "R-MMU-4332222",
    "displayName" : "NEDD8-K556,K567-TGFBR2 [plasma membrane]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48892,
    "diagramIds" : [ 120172 ],
    "identifier" : "Q62312",
    "standardIdentifier" : "uniprot:Q62312",
    "referenceType" : "ReferenceGeneProduct",
    "parents" : [ ],
    "children" : [ ]
  }, {
    "dbId" : 10050632,
    "stId" : "R-MMU-4419894",
    "displayName" : "Ube2m [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48892,
    "identifier" : "P61082",
    "standardIdentifier" : "uniprot:P61082",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "Ube2m" ],
    "parents" : [ 10050634 ],
    "children" : [ ]
  }, {
    "dbId" : 10050634,
    "stId" : "R-MMU-4419896",
    "displayName" : "NEDD8-AcM-UBE2M [cytosol]",
    "schemaClass" : "Complex",
    "speciesId" : 48892,
    "diagramIds" : [ 120170 ],
    "parents" : [ ],
    "children" : [ 10050628, 10050632 ]
  }, {
    "dbId" : 10050636,
    "stId" : "R-MMU-8951627",
    "displayName" : "Ube2m [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48892,
    "diagramIds" : [ 120171 ],
    "identifier" : "P61082",
    "standardIdentifier" : "uniprot:P61082",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "Ube2m" ],
    "parents" : [ ],
    "children" : [ ]
  }, {
    "dbId" : 434908,
    "stId" : "R-MMU-434908",
    "displayName" : "Itgb1 [plasma membrane]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48892,
    "identifier" : "P09055",
    "standardIdentifier" : "uniprot:P09055",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "Itgb1" ],
    "parents" : [ 10007228, 10007230 ],
    "children" : [ ]
  }, {
    "dbId" : 10050628,
    "stId" : "R-MMU-4419895",
    "displayName" : "Nedd8 [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48892,
    "identifier" : "P29595",
    "standardIdentifier" : "uniprot:P29595",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "Nedd8" ],
    "parents" : [ 10050634 ],
    "children" : [ ]
  }, {
    "dbId" : 9997432,
    "stId" : "R-MMU-170863",
    "displayName" : "p-TGFBR1 [plasma membrane]",
    "schemaClass" : "Complex",
    "speciesId" : 48892,
    "parents" : [ 9997434, 9997448, 9997515, 9997513 ],
    "children" : [ 9997430 ]
  }, {
    "dbId" : 9997689,
    "stId" : "R-MMU-173476",
    "displayName" : "TGFB1: p-TGFBR: I-SMAD7 [plasma membrane]",
    "schemaClass" : "Complex",
    "speciesId" : 48892,
    "diagramIds" : [ 120126 ],
    "parents" : [ 10043309 ],
    "children" : [ 2161209, 9997434 ]
  }, {
    "dbId" : 9997434,
    "stId" : "R-MMU-170841",
    "displayName" : "TGFB1:TGFBR2:p-TGFBR1 [plasma membrane]",
    "schemaClass" : "Complex",
    "speciesId" : 48892,
    "diagramIds" : [ 120103 ],
    "parents" : [ 10042555, 9997676, 10041907, 9997689 ],
    "children" : [ 9997415, 9997420, 9997432 ]
  }, {
    "dbId" : 10034556,
    "stId" : "R-MMU-2159853",
    "displayName" : "Fbn1 [extracellular region]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48892,
    "identifier" : "Q61554",
    "standardIdentifier" : "uniprot:Q61554",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "Fbn1" ],
    "parents" : [ 10034558 ],
    "children" : [ ]
  }, {
    "dbId" : 9995133,
    "stId" : "R-MMU-157049",
    "displayName" : "FURIN [Golgi membrane]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48892,
    "diagramIds" : [ 120088 ],
    "identifier" : "P23188",
    "standardIdentifier" : "uniprot:P23188",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "Furin", "Fur", "Pcsk3" ],
    "parents" : [ ],
    "children" : [ ]
  }, {
    "dbId" : 9997694,
    "stId" : "R-MMU-2176457",
    "displayName" : "SMAD2:SMURF2 [cytosol]",
    "schemaClass" : "Complex",
    "speciesId" : 48892,
    "diagramIds" : [ 120139 ],
    "parents" : [ ],
    "children" : [ 9997441, 5632468 ]
  }, {
    "dbId" : 9997438,
    "stId" : "R-MMU-206180",
    "displayName" : "Zfyve9 [early endosome membrane]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48892,
    "diagramIds" : [ 120106 ],
    "identifier" : "A2A8R0",
    "standardIdentifier" : "uniprot:A2A8R0",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "Zfyve9" ],
    "parents" : [ 9997448, 9997515, 9997513 ],
    "children" : [ ]
  }, {
    "dbId" : 10034558,
    "stId" : "R-MMU-2159874",
    "displayName" : "Fibrillin-1 [extracellular region]",
    "schemaClass" : "Polymer",
    "speciesId" : 48892,
    "diagramIds" : [ 120192 ],
    "parents" : [ 10044330 ],
    "children" : [ 10034556 ]
  }, {
    "dbId" : 9997430,
    "stId" : "R-MMU-170849",
    "displayName" : "phospho-p-4S,T185,T186-TGFBR1 [plasma membrane]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48892,
    "identifier" : "Q64729",
    "standardIdentifier" : "uniprot:Q64729",
    "referenceType" : "ReferenceGeneProduct",
    "parents" : [ 9997432 ],
    "children" : [ ]
  }, {
    "dbId" : 9997673,
    "stId" : "R-MMU-173484",
    "displayName" : "Bambi [plasma membrane]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48892,
    "diagramIds" : [ 120164 ],
    "identifier" : "Q9D0L6",
    "standardIdentifier" : "uniprot:Q9D0L6",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "Bambi" ],
    "parents" : [ 9997676 ],
    "children" : [ ]
  }, {
    "dbId" : 9997418,
    "stId" : "R-MMU-170838",
    "displayName" : "Tgfb1 [extracellular region]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48892,
    "identifier" : "P04202",
    "standardIdentifier" : "uniprot:P04202",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "Tgfb1" ],
    "parents" : [ 9997487, 9997420 ],
    "children" : [ ]
  }, {
    "dbId" : 9997420,
    "stId" : "R-MMU-170852",
    "displayName" : "Dimeric TGFB1 [extracellular region]",
    "schemaClass" : "Complex",
    "speciesId" : 48892,
    "diagramIds" : [ 120093 ],
    "parents" : [ 9999492, 9997475, 9997456, 9997434, 9997448, 9997515, 9997513 ],
    "children" : [ 9997418 ]
  }, {
    "dbId" : 9997676,
    "stId" : "R-MMU-173509",
    "displayName" : "TGFB1: TGFBR2: p-TGFBR1: BAMBI: SMAD7 [plasma membrane]",
    "schemaClass" : "Complex",
    "speciesId" : 48892,
    "diagramIds" : [ 120165 ],
    "parents" : [ ],
    "children" : [ 2161209, 9997434, 9997673 ]
  }, {
    "dbId" : 10044512,
    "stId" : "R-MMU-2396408",
    "displayName" : "LAP3-binding integrins [plasma membrane]",
    "schemaClass" : "DefinedSet",
    "speciesId" : 48892,
    "diagramIds" : [ 120188 ],
    "parents" : [ 10044514 ],
    "children" : [ 10007236, 10007315, 10007230, 10007309, 10006413 ]
  }, {
    "dbId" : 10044514,
    "stId" : "R-MMU-2396121",
    "displayName" : "TGF-beta-3:LAP3:LAP3-binding integrins [plasma membrane]",
    "schemaClass" : "Complex",
    "speciesId" : 48892,
    "diagramIds" : [ 120190 ],
    "parents" : [ ],
    "children" : [ 10044374, 10044512 ]
  }, {
    "dbId" : 9997413,
    "stId" : "R-MMU-170842",
    "displayName" : "TGFBR2 [plasma membrane]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48892,
    "diagramIds" : [ 120092 ],
    "identifier" : "Q62312",
    "standardIdentifier" : "uniprot:Q62312",
    "referenceType" : "ReferenceGeneProduct",
    "parents" : [ 10050621, 9997491, 9997415 ],
    "children" : [ ]
  }, {
    "dbId" : 9997415,
    "stId" : "R-MMU-170866",
    "displayName" : "TGFBR2 homodimer [plasma membrane]",
    "schemaClass" : "Complex",
    "speciesId" : 48892,
    "parents" : [ 9997475, 9997456, 9997434, 9997448, 9997515, 9997513 ],
    "children" : [ 9997413 ]
  } ],
  "edges" : [ {
    "dbId" : 9999834,
    "stId" : "R-MMU-178208",
    "displayName" : "SMAD7 binds to SMURF2",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "inputs" : [ 9999830, 2167887 ],
    "outputs" : [ 9999832 ],
    "efs" : [ ],
    "diagramIds" : [ 120130 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10043359,
    "stId" : "R-MMU-2176445",
    "displayName" : "SMURF2 binds SMAD2",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "following" : [ 9997699 ],
    "inputs" : [ 9997441, 5632468 ],
    "outputs" : [ 9997694 ],
    "efs" : [ ],
    "diagramIds" : [ 120136 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10050643,
    "stId" : "R-MMU-4332236",
    "displayName" : "CBL neddylates TGFBR2",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "preceding" : [ 10050623 ],
    "inputs" : [ 10050621, 10050634 ],
    "outputs" : [ 10050640, 10050636, 9999882 ],
    "catalysts" : [ 10050621 ],
    "efs" : [ ],
    "diagramIds" : [ 120169 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 9997523,
    "stId" : "R-MMU-170861",
    "displayName" : "Dimeric TGF-beta-1 binds to the receptor",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "following" : [ 9997493 ],
    "inputs" : [ 9997413, 9997420 ],
    "outputs" : [ 9997475 ],
    "efs" : [ ],
    "inhibitors" : [ 9997521 ],
    "activators" : [ 9997491 ],
    "diagramIds" : [ 120091 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 9997459,
    "stId" : "R-MMU-170843",
    "displayName" : "TGFBR2 phosphorylates TGFBR1",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "preceding" : [ 9997493 ],
    "following" : [ 9997450 ],
    "inputs" : [ 113592, 9997456 ],
    "outputs" : [ 29370, 9997434 ],
    "catalysts" : [ 9997456 ],
    "efs" : [ ],
    "diagramIds" : [ 120101 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 9997527,
    "stId" : "R-MMU-170868",
    "displayName" : "Activated type I receptor phosphorylates SMAD2/3 directly",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "preceding" : [ 9997450 ],
    "following" : [ 9997517 ],
    "inputs" : [ 113592, 9997448 ],
    "outputs" : [ 29370, 9997513 ],
    "catalysts" : [ 9997448 ],
    "efs" : [ ],
    "diagramIds" : [ 120109 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 9997450,
    "stId" : "R-MMU-170835",
    "displayName" : "An anchoring protein, ZFYVE9 (SARA), recruits SMAD2/3",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "preceding" : [ 9997459 ],
    "following" : [ 9997527 ],
    "inputs" : [ 9997446, 9997438, 9997434 ],
    "outputs" : [ 9997448 ],
    "efs" : [ ],
    "diagramIds" : [ 120105 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10044364,
    "stId" : "R-MMU-2395320",
    "displayName" : "Latent TGF-beta-1 binds integrins",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "preceding" : [ 10044386 ],
    "inputs" : [ 10044358, 10044360 ],
    "outputs" : [ 10044362 ],
    "efs" : [ ],
    "diagramIds" : [ 120183 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 9997517,
    "stId" : "R-MMU-170850",
    "displayName" : "Phosphorylated SMAD2/3 dissociates from TGFBR",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "preceding" : [ 9997527 ],
    "following" : [ 10043559, 10043589, 9997511 ],
    "inputs" : [ 9997513 ],
    "outputs" : [ 9997501, 9997515 ],
    "efs" : [ ],
    "diagramIds" : [ 120113 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10042561,
    "stId" : "R-MMU-2160931",
    "displayName" : "Disassembly of tight junctions",
    "schemaClass" : "BlackBoxEvent",
    "speciesId" : 0,
    "preceding" : [ 10042565 ],
    "inputs" : [ 10042559 ],
    "efs" : [ ],
    "diagramIds" : [ 120123 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10042563,
    "stId" : "R-MMU-2160932",
    "displayName" : "SMURF1 binds phosphorylated PARD6A",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "following" : [ 10042565 ],
    "inputs" : [ 10003659, 10042555 ],
    "outputs" : [ 10042557 ],
    "efs" : [ ],
    "diagramIds" : [ 120116 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10043587,
    "stId" : "R-MMU-2187401",
    "displayName" : "MTMR4 dephosphorylates SMAD2/3",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "preceding" : [ 10043589 ],
    "inputs" : [ 29356, 10043584 ],
    "outputs" : [ 9997446, 29372, 10043582 ],
    "catalysts" : [ 10043584 ],
    "efs" : [ ],
    "diagramIds" : [ 120160 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 9997699,
    "stId" : "R-MMU-173542",
    "displayName" : "SMURF2 ubiquitinates SMAD2",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "preceding" : [ 10043359 ],
    "following" : [ 10043361 ],
    "inputs" : [ 9997694, 9985374 ],
    "outputs" : [ 9997696, 5632468 ],
    "catalysts" : [ 9997694 ],
    "efs" : [ ],
    "diagramIds" : [ 120142 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10042565,
    "stId" : "R-MMU-2160935",
    "displayName" : "SMURF1 ubiquitinates RHOA",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "preceding" : [ 10042563 ],
    "following" : [ 10042561 ],
    "inputs" : [ 9985374, 10042557 ],
    "outputs" : [ 10042559 ],
    "efs" : [ ],
    "diagramIds" : [ 120120 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10043589,
    "stId" : "R-MMU-2187405",
    "displayName" : "MTMR4 binds phosphorylated SMAD2/3",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "preceding" : [ 9997517 ],
    "following" : [ 10043587 ],
    "inputs" : [ 10043582, 9997501 ],
    "outputs" : [ 10043584 ],
    "efs" : [ ],
    "diagramIds" : [ 120157 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 9999494,
    "stId" : "R-MMU-177107",
    "displayName" : "Secretion and activation of the latent large complex of TGF-beta-1",
    "schemaClass" : "BlackBoxEvent",
    "speciesId" : 0,
    "preceding" : [ 9997473 ],
    "inputs" : [ 9997471 ],
    "outputs" : [ 9999492 ],
    "efs" : [ ],
    "diagramIds" : [ 120089 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 9997511,
    "stId" : "R-MMU-170847",
    "displayName" : "Phosphorylated SMAD2 and SMAD3 form a complex with SMAD4",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "preceding" : [ 9997517 ],
    "inputs" : [ 9997501, 9997497 ],
    "outputs" : [ 9997509 ],
    "efs" : [ ],
    "diagramIds" : [ 120173 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10043576,
    "stId" : "R-MMU-2187382",
    "displayName" : "Degradation of ubiquitinated SMAD3",
    "schemaClass" : "BlackBoxEvent",
    "speciesId" : 0,
    "preceding" : [ 10043572 ],
    "inputs" : [ 10043569 ],
    "efs" : [ ],
    "diagramIds" : [ 120156 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 9997691,
    "stId" : "R-MMU-173512",
    "displayName" : "I-SMAD competes with SMAD2/3 for type I receptor (TGFBR1)",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "inputs" : [ 2161209, 9997434 ],
    "outputs" : [ 9997689 ],
    "efs" : [ ],
    "diagramIds" : [ 120124 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10050623,
    "stId" : "R-MMU-4332235",
    "displayName" : "CBL binds TGFBR2",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "following" : [ 10050643 ],
    "inputs" : [ 9997413, 9999882 ],
    "outputs" : [ 10050621 ],
    "efs" : [ ],
    "diagramIds" : [ 120166 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10043572,
    "stId" : "R-MMU-2187368",
    "displayName" : "STUB1 (CHIP) ubiquitinates SMAD3",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "preceding" : [ 10043574 ],
    "following" : [ 10043576 ],
    "inputs" : [ 9985374, 10043567 ],
    "outputs" : [ 10026386, 10043569 ],
    "catalysts" : [ 10043567 ],
    "efs" : [ ],
    "diagramIds" : [ 120154 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 9997493,
    "stId" : "R-MMU-170846",
    "displayName" : "TGFBR2 recruits TGFBR1",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "preceding" : [ 9997523 ],
    "following" : [ 9997459 ],
    "inputs" : [ 9997477, 9997475 ],
    "outputs" : [ 9996339, 9997456 ],
    "efs" : [ ],
    "activators" : [ 9997491 ],
    "diagramIds" : [ 120097 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10041911,
    "stId" : "R-MMU-2128994",
    "displayName" : "STRAP stabilizes interaction of activated TGF-beta receptor complex with SMAD7",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "inputs" : [ 10041907, 2161209 ],
    "outputs" : [ 10041909 ],
    "efs" : [ ],
    "diagramIds" : [ 120127 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10043574,
    "stId" : "R-MMU-2187375",
    "displayName" : "SMAD3 binds STUB1 (CHIP)",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "following" : [ 10043572 ],
    "inputs" : [ 9997444, 10026386 ],
    "outputs" : [ 10043567 ],
    "efs" : [ ],
    "diagramIds" : [ 120150 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10043565,
    "stId" : "R-MMU-2187358",
    "displayName" : "PMEPA1 sequesters unphosphorylated SMAD2/3",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "inputs" : [ 9997446, 10043561 ],
    "outputs" : [ 10043563 ],
    "efs" : [ ],
    "diagramIds" : [ 120147 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10044332,
    "stId" : "R-MMU-2328033",
    "displayName" : "Fibrillin-1 binds latent TGF-beta",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "inputs" : [ 10034558, 10044328 ],
    "outputs" : [ 10044330 ],
    "efs" : [ ],
    "diagramIds" : [ 120191 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 9997678,
    "stId" : "R-MMU-173483",
    "displayName" : "BAMBI interferes with the interaction of type I receptor with type II receptor",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "inputs" : [ 2161209, 9997434, 9997673 ],
    "outputs" : [ 9997676 ],
    "efs" : [ ],
    "diagramIds" : [ 120163 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10043311,
    "stId" : "R-MMU-2169046",
    "displayName" : "Degradation of TGF-beta receptor complex",
    "schemaClass" : "BlackBoxEvent",
    "speciesId" : 0,
    "inputs" : [ 10043309 ],
    "efs" : [ ],
    "diagramIds" : [ 120134 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10043361,
    "stId" : "R-MMU-2176452",
    "displayName" : "Degradation of ubiquitinated SMAD2",
    "schemaClass" : "BlackBoxEvent",
    "speciesId" : 0,
    "preceding" : [ 9997699 ],
    "inputs" : [ 9997696 ],
    "efs" : [ ],
    "diagramIds" : [ 120140 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 9997473,
    "stId" : "R-MMU-170844",
    "displayName" : "Latent TGF-beta-1 is cleaved by FURIN",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "following" : [ 9999494 ],
    "inputs" : [ 9997463 ],
    "outputs" : [ 9997471 ],
    "catalysts" : [ 9995133 ],
    "efs" : [ ],
    "diagramIds" : [ 120085 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10044386,
    "stId" : "R-MMU-2395328",
    "displayName" : "LTBP1, LTBP3 bind TGF-Beta",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "following" : [ 10044364 ],
    "inputs" : [ 10044366, 10044376 ],
    "outputs" : [ 10044384 ],
    "efs" : [ ],
    "diagramIds" : [ 120176 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10044516,
    "stId" : "R-MMU-2396029",
    "displayName" : "Latent TGF-beta-3 binds integrins",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "inputs" : [ 10044374, 10044512 ],
    "outputs" : [ 10044514 ],
    "efs" : [ ],
    "diagramIds" : [ 120187 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10043559,
    "stId" : "R-MMU-2187355",
    "displayName" : "PMEPA1 sequesters phosphorylated SMAD2/3",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "preceding" : [ 9997517 ],
    "inputs" : [ 10043555, 9997501 ],
    "outputs" : [ 10043557 ],
    "efs" : [ ],
    "diagramIds" : [ 120144 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10044390,
    "stId" : "R-MMU-2395364",
    "displayName" : "LTBP4 binds TGF-Beta-1",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "inputs" : [ 9999492, 10044318 ],
    "outputs" : [ 10044388 ],
    "efs" : [ ],
    "diagramIds" : [ 120180 ],
    "entityFunctionalStatus" : [ ]
  } ],
  "subpathways" : [ {
    "dbId" : 10100873,
    "stId" : "R-MMU-2173791",
    "displayName" : "TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)",
    "events" : [ 10042561, 10042563, 10042565 ]
  }, {
    "dbId" : 10099409,
    "stId" : "R-MMU-2173788",
    "displayName" : "Downregulation of TGF-beta receptor signaling",
    "events" : [ 10043576, 9999834, 9997691, 10043359, 10043572, 10041911, 10043574, 10043565, 9997678, 10043311, 10043361, 10043587, 9997699, 10043589, 10043559 ]
  }, {
    "dbId" : 10099381,
    "stId" : "R-MMU-2173789",
    "displayName" : "TGF-beta receptor signaling activates SMADs",
    "events" : [ 10050623, 10050643, 9997523, 9997459, 10043576, 9999834, 9997691, 10043359, 10043572, 10041911, 10043574, 10043565, 9997678, 10043311, 10043361, 10043587, 9997699, 10043589, 10043559, 9997493, 9997527, 9997450, 10044332, 10044364, 9997517, 9997473, 10044386, 10044516, 9999494, 10044390, 9997511 ]
  } ]
}