{ "dbId" : 10099291, "stableId" : "R-MMU-166058", "displayName" : "MyD88:MAL(TIRAP) cascade initiated on plasma membrane", "nodes" : [ { "id" : 113227, "reactomeId" : 10099345, "displayName" : "TAK1-dependent IKK and NF-kappa-B activation", "schemaClass" : "Pathway", "renderableClass" : "ProcessNode", "position" : { "x" : 1233, "y" : 340 }, "minX" : 1171, "maxX" : 1296, "minY" : 297, "maxY" : 383, "prop" : { "x" : 1171, "y" : 297, "width" : 125, "height" : 86 }, "textPosition" : { "x" : 1172, "y" : 304 }, "connectors" : [ ] }, { "id" : 113226, "reactomeId" : 10099317, "displayName" : "MAP kinase activation", "schemaClass" : "Pathway", "renderableClass" : "ProcessNode", "position" : { "x" : 1093, "y" : 353 }, "minX" : 1032, "maxX" : 1155, "minY" : 324, "maxY" : 382, "prop" : { "x" : 1032, "y" : 324, "width" : 123, "height" : 58 }, "textPosition" : { "x" : 1048, "y" : 331 }, "connectors" : [ ] }, { "id" : 113237, "reactomeId" : 10101141, "displayName" : "Regulation of TLR by endogenous ligand", "schemaClass" : "Pathway", "renderableClass" : "EncapsulatedNode", "position" : { "x" : 89, "y" : 27 }, "minX" : 0, "maxX" : 178, "minY" : 0, "maxY" : 55, "prop" : { "x" : 0, "y" : 0, "width" : 178, "height" : 55 }, "textPosition" : { "x" : 16, "y" : 6 }, "connectors" : [ ] }, { "id" : 113177, "reactomeId" : 9996710, "displayName" : "MAP3K1", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 1090, "y" : 751 }, "minX" : 1062, "maxX" : 1164, "minY" : 734, "maxY" : 789, "prop" : { "x" : 1062, "y" : 740, "width" : 57, "height" : 22 }, "textPosition" : { "x" : 1062, "y" : 740 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1119, "y" : 740 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1119, "y" : 740 } } }, "connectors" : [ { "edgeId" : 113175, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1111, "y" : 765 }, "to" : { "x" : 1164, "y" : 789 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 113176, "reactomeId" : 9996713, "displayName" : "Traf6", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 1107, "y" : 841 }, "minX" : 1084, "maxX" : 1164, "minY" : 789, "maxY" : 852, "prop" : { "x" : 1084, "y" : 830, "width" : 46, "height" : 22 }, "textPosition" : { "x" : 1087, "y" : 830 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1130, "y" : 830 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1130, "y" : 830 } } }, "connectors" : [ { "edgeId" : 113175, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1119, "y" : 827 }, "to" : { "x" : 1164, "y" : 789 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 113179, "reactomeId" : 9996719, "displayName" : "Ecsit", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 1195, "y" : 741 }, "minX" : 1173, "maxX" : 1224, "minY" : 724, "maxY" : 780, "prop" : { "x" : 1173, "y" : 730, "width" : 45, "height" : 22 }, "textPosition" : { "x" : 1176, "y" : 730 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1218, "y" : 730 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1218, "y" : 730 } } }, "connectors" : [ { "edgeId" : 113175, "type" : "ACTIVATOR", "segments" : [ { "from" : { "x" : 1194, "y" : 755 }, "to" : { "x" : 1194, "y" : 780 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1190, "y" : 773 }, "b" : { "x" : 1194, "y" : 780 }, "c" : { "x" : 1198, "y" : 773 }, "type" : "ARROW", "empty" : true, "centre" : { "x" : 1198, "y" : 773 } } } ] }, { "id" : 113178, "reactomeId" : 9996715, "displayName" : "MEKK1:activated TRAF6", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 1289, "y" : 791 }, "minX" : 1232, "maxX" : 1353, "minY" : 767, "maxY" : 809, "prop" : { "x" : 1232, "y" : 773, "width" : 115, "height" : 36 }, "textPosition" : { "x" : 1232, "y" : 774 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1347, "y" : 773 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1347, "y" : 773 } } }, "connectors" : [ { "edgeId" : 113175, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 113181, "reactomeId" : 10022811, "displayName" : "TRAF6:p-IRAK2", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 428, "y" : 104 }, "minX" : 378, "maxX" : 485, "minY" : 87, "maxY" : 133, "prop" : { "x" : 378, "y" : 93, "width" : 101, "height" : 22 }, "textPosition" : { "x" : 380, "y" : 94 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 479, "y" : 93 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 479, "y" : 93 } } }, "connectors" : [ { "edgeId" : 113180, "type" : "INPUT", "segments" : [ { "from" : { "x" : 444, "y" : 118 }, "to" : { "x" : 472, "y" : 133 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 113183, "reactomeId" : 10022813, "displayName" : "p-IRAK2:oligo-TRAF6", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 546, "y" : 96 }, "minX" : 499, "maxX" : 659, "minY" : 72, "maxY" : 124, "prop" : { "x" : 499, "y" : 78, "width" : 94, "height" : 36 }, "textPosition" : { "x" : 500, "y" : 79 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 593, "y" : 78 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 593, "y" : 78 } } }, "connectors" : [ { "edgeId" : 113180, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 113196, "type" : "INPUT", "segments" : [ { "from" : { "x" : 596, "y" : 113 }, "to" : { "x" : 623, "y" : 124 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 113196, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 596, "y" : 96 }, "to" : { "x" : 652, "y" : 97 } }, { "from" : { "x" : 652, "y" : 97 }, "to" : { "x" : 654, "y" : 108 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 655, "y" : 112 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 655, "y" : 112 } } } ] }, { "id" : 113182, "reactomeId" : 9996713, "displayName" : "Traf6", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 461, "y" : 183 }, "minX" : 438, "maxX" : 490, "minY" : 133, "maxY" : 194, "prop" : { "x" : 438, "y" : 172, "width" : 46, "height" : 22 }, "textPosition" : { "x" : 441, "y" : 172 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 484, "y" : 172 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 484, "y" : 172 } } }, "connectors" : [ { "edgeId" : 113180, "type" : "INPUT", "segments" : [ { "from" : { "x" : 463, "y" : 169 }, "to" : { "x" : 472, "y" : 133 } } ], "stoichiometry" : { "value" : 2, "shape" : { "a" : { "x" : 461, "y" : 145 }, "b" : { "x" : 473, "y" : 157 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 467, "y" : 151 } } } } ] }, { "id" : 113185, "reactomeId" : 10022864, "displayName" : "TRAF6:hp-IRAK1", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 1513, "y" : 670 }, "minX" : 1459, "maxX" : 1573, "minY" : 609, "maxY" : 681, "prop" : { "x" : 1459, "y" : 659, "width" : 108, "height" : 22 }, "textPosition" : { "x" : 1461, "y" : 660 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "fgColor" : { "r" : 0, "g" : 0, "b" : 0 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1567, "y" : 659 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1567, "y" : 659 } } }, "connectors" : [ { "edgeId" : 113184, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1508, "y" : 656 }, "to" : { "x" : 1490, "y" : 609 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 113187, "reactomeId" : 10022866, "displayName" : "TRAF6:hp-IRAK1:Pellino", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 1521, "y" : 516 }, "minX" : 1466, "maxX" : 1582, "minY" : 446, "maxY" : 534, "prop" : { "x" : 1466, "y" : 498, "width" : 110, "height" : 36 }, "textPosition" : { "x" : 1467, "y" : 499 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1576, "y" : 498 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1576, "y" : 498 } } }, "connectors" : [ { "edgeId" : 113184, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 113188, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1508, "y" : 495 }, "to" : { "x" : 1495, "y" : 478 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 113188, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 1519, "y" : 495 }, "to" : { "x" : 1517, "y" : 452 } }, { "from" : { "x" : 1517, "y" : 452 }, "to" : { "x" : 1510, "y" : 451 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 1506, "y" : 450 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1506, "y" : 450 } } } ] }, { "id" : 113186, "reactomeId" : 10018968, "displayName" : "p-Pellino-1,2,(3)", "schemaClass" : "CandidateSet", "renderableClass" : "EntitySet", "position" : { "x" : 1403, "y" : 634 }, "minX" : 1325, "maxX" : 1490, "minY" : 243, "maxY" : 645, "prop" : { "x" : 1350, "y" : 623, "width" : 107, "height" : 22 }, "textPosition" : { "x" : 1350, "y" : 623 }, "connectors" : [ { "edgeId" : 113184, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1441, "y" : 617 }, "to" : { "x" : 1490, "y" : 609 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 113191, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 1376, "y" : 617 }, "to" : { "x" : 1325, "y" : 602 } }, { "from" : { "x" : 1325, "y" : 602 }, "to" : { "x" : 1326, "y" : 244 } }, { "from" : { "x" : 1326, "y" : 244 }, "to" : { "x" : 1484, "y" : 243 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1368, "y" : 619 }, "b" : { "x" : 1376, "y" : 617 }, "c" : { "x" : 1370, "y" : 611 }, "type" : "ARROW", "centre" : { "x" : 1370, "y" : 611 } } } ] }, { "id" : 113189, "reactomeId" : 113592, "displayName" : "ATP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1437, "y" : 483 }, "minX" : 1417, "maxX" : 1495, "minY" : 467, "maxY" : 498, "prop" : { "x" : 1417, "y" : 468, "width" : 40, "height" : 30 }, "textPosition" : { "x" : 1421, "y" : 472 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1452, "y" : 473 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1452, "y" : 473 } } }, "connectors" : [ { "edgeId" : 113188, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1460, "y" : 481 }, "to" : { "x" : 1495, "y" : 478 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 113190, "reactomeId" : 29370, "displayName" : "ADP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1435, "y" : 422 }, "minX" : 1415, "maxX" : 1457, "minY" : 406, "maxY" : 437, "prop" : { "x" : 1415, "y" : 407, "width" : 41, "height" : 30 }, "textPosition" : { "x" : 1419, "y" : 411 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1451, "y" : 412 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1451, "y" : 412 } } }, "connectors" : [ { "edgeId" : 113188, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 113193, "reactomeId" : 9997047, "displayName" : "UBE2N:UBE2V1", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 1395, "y" : 281 }, "minX" : 1343, "maxX" : 1484, "minY" : 243, "maxY" : 305, "prop" : { "x" : 1343, "y" : 270, "width" : 104, "height" : 22 }, "textPosition" : { "x" : 1343, "y" : 271 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1447, "y" : 270 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1447, "y" : 270 } } }, "connectors" : [ { "edgeId" : 113191, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1435, "y" : 295 }, "to" : { "x" : 1484, "y" : 305 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 113191, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 1420, "y" : 267 }, "to" : { "x" : 1484, "y" : 243 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1425, "y" : 261 }, "b" : { "x" : 1420, "y" : 267 }, "c" : { "x" : 1428, "y" : 268 }, "type" : "ARROW", "centre" : { "x" : 1428, "y" : 268 } } } ] }, { "id" : 113192, "reactomeId" : 9997017, "displayName" : "K63polyUb", "schemaClass" : "Polymer", "renderableClass" : "Entity", "position" : { "x" : 1403, "y" : 344 }, "minX" : 1366, "maxX" : 1484, "minY" : 305, "maxY" : 355, "prop" : { "x" : 1366, "y" : 333, "width" : 74, "height" : 22 }, "textPosition" : { "x" : 1366, "y" : 333 }, "connectors" : [ { "edgeId" : 113191, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1425, "y" : 330 }, "to" : { "x" : 1484, "y" : 305 } } ], "stoichiometry" : { "value" : 2, "shape" : { "a" : { "x" : 1448, "y" : 311 }, "b" : { "x" : 1460, "y" : 323 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1454, "y" : 317 } } } } ] }, { "id" : 113195, "reactomeId" : 10022856, "displayName" : "K63-linked polyUb p-IRAK1:TRAF6", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 1514, "y" : 192 }, "minX" : 1411, "maxX" : 1582, "minY" : 168, "maxY" : 243, "prop" : { "x" : 1452, "y" : 174, "width" : 124, "height" : 36 }, "textPosition" : { "x" : 1453, "y" : 175 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1576, "y" : 174 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1576, "y" : 174 } } }, "connectors" : [ { "edgeId" : 113191, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 1503, "y" : 213 }, "to" : { "x" : 1484, "y" : 243 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1503, "y" : 221 }, "b" : { "x" : 1503, "y" : 213 }, "c" : { "x" : 1496, "y" : 217 }, "type" : "ARROW", "centre" : { "x" : 1496, "y" : 217 } } }, { "edgeId" : 113206, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1449, "y" : 184 }, "to" : { "x" : 1411, "y" : 179 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 113194, "reactomeId" : 10022866, "displayName" : "TRAF6:hp-IRAK1:Pellino", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 1533, "y" : 383 }, "minX" : 1471, "maxX" : 1602, "minY" : 266, "maxY" : 401, "prop" : { "x" : 1471, "y" : 365, "width" : 125, "height" : 36 }, "textPosition" : { "x" : 1479, "y" : 366 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1596, "y" : 365 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1596, "y" : 365 } } }, "connectors" : [ { "edgeId" : 113191, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1521, "y" : 362 }, "to" : { "x" : 1484, "y" : 305 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 113191, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 1528, "y" : 362 }, "to" : { "x" : 1503, "y" : 271 } }, { "from" : { "x" : 1503, "y" : 271 }, "to" : { "x" : 1500, "y" : 271 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 1496, "y" : 270 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1496, "y" : 270 } } } ] }, { "id" : 113197, "reactomeId" : 9985374, "displayName" : "Ub", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 595, "y" : 159 }, "minX" : 583, "maxX" : 623, "minY" : 124, "maxY" : 170, "prop" : { "x" : 583, "y" : 148, "width" : 25, "height" : 22 }, "textPosition" : { "x" : 583, "y" : 148 }, "connectors" : [ { "edgeId" : 113196, "type" : "INPUT", "segments" : [ { "from" : { "x" : 603, "y" : 142 }, "to" : { "x" : 623, "y" : 124 } } ], "stoichiometry" : { "value" : 9, "shape" : { "a" : { "x" : 607, "y" : 127 }, "b" : { "x" : 619, "y" : 139 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 613, "y" : 133 } } } }, { "edgeId" : 113199, "type" : "INPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 113198, "reactomeId" : 10022818, "displayName" : "p-IRAK2:K63-linked pUb oligo-TRAF6", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 753, "y" : 96 }, "minX" : 668, "maxX" : 865, "minY" : 72, "maxY" : 156, "prop" : { "x" : 689, "y" : 78, "width" : 129, "height" : 36 }, "textPosition" : { "x" : 690, "y" : 79 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "fgColor" : { "r" : 0, "g" : 0, "b" : 0 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 818, "y" : 78 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 818, "y" : 78 } } }, "connectors" : [ { "edgeId" : 113209, "type" : "INPUT", "segments" : [ { "from" : { "x" : 814, "y" : 117 }, "to" : { "x" : 865, "y" : 129 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 113196, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 113199, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 727, "y" : 117 }, "to" : { "x" : 675, "y" : 150 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 672, "y" : 152 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 672, "y" : 152 } } } ] }, { "id" : 113200, "reactomeId" : 9997017, "displayName" : "K63polyUb", "schemaClass" : "Polymer", "renderableClass" : "Entity", "position" : { "x" : 772, "y" : 160 }, "minX" : 735, "maxX" : 865, "minY" : 129, "maxY" : 171, "prop" : { "x" : 735, "y" : 149, "width" : 74, "height" : 22 }, "textPosition" : { "x" : 735, "y" : 149 }, "connectors" : [ { "edgeId" : 113209, "type" : "INPUT", "segments" : [ { "from" : { "x" : 805, "y" : 146 }, "to" : { "x" : 865, "y" : 129 } } ], "stoichiometry" : { "value" : 3, "shape" : { "a" : { "x" : 829, "y" : 131 }, "b" : { "x" : 841, "y" : 143 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 835, "y" : 137 } } } }, { "edgeId" : 113199, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 113203, "reactomeId" : 10022836, "displayName" : "p-IRAK2:K63-linked pUb oligo-TRAF6:free K63 pUb:TAK1 complex", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 995, "y" : 112 }, "minX" : 930, "maxX" : 1134, "minY" : 74, "maxY" : 144, "prop" : { "x" : 930, "y" : 80, "width" : 131, "height" : 64 }, "textPosition" : { "x" : 932, "y" : 81 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1061, "y" : 80 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1061, "y" : 80 } } }, "connectors" : [ { "edgeId" : 113201, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1064, "y" : 123 }, "to" : { "x" : 1100, "y" : 131 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 113201, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 1064, "y" : 112 }, "to" : { "x" : 1124, "y" : 112 } }, { "from" : { "x" : 1124, "y" : 112 }, "to" : { "x" : 1128, "y" : 117 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 1130, "y" : 120 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1130, "y" : 120 } } }, { "edgeId" : 113209, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 113202, "reactomeId" : 113592, "displayName" : "ATP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1069, "y" : 172 }, "minX" : 1049, "maxX" : 1100, "minY" : 131, "maxY" : 187, "prop" : { "x" : 1049, "y" : 157, "width" : 40, "height" : 30 }, "textPosition" : { "x" : 1053, "y" : 161 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1084, "y" : 162 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1084, "y" : 162 } } }, "connectors" : [ { "edgeId" : 113201, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1080, "y" : 154 }, "to" : { "x" : 1100, "y" : 131 } } ], "stoichiometry" : { "value" : 6, "shape" : { "a" : { "x" : 1084, "y" : 136 }, "b" : { "x" : 1096, "y" : 148 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1090, "y" : 142 } } } } ] }, { "id" : 113205, "reactomeId" : 29370, "displayName" : "ADP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1187, "y" : 179 }, "minX" : 1167, "maxX" : 1209, "minY" : 130, "maxY" : 194, "prop" : { "x" : 1167, "y" : 164, "width" : 41, "height" : 30 }, "textPosition" : { "x" : 1171, "y" : 168 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1203, "y" : 169 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1203, "y" : 169 } } }, "connectors" : [ { "edgeId" : 113201, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 1183, "y" : 161 }, "to" : { "x" : 1174, "y" : 130 } } ], "stoichiometry" : { "value" : 6, "shape" : { "a" : { "x" : 1172, "y" : 139 }, "b" : { "x" : 1184, "y" : 151 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1178, "y" : 145 } } }, "endShape" : { "a" : { "x" : 1177, "y" : 155 }, "b" : { "x" : 1183, "y" : 161 }, "c" : { "x" : 1185, "y" : 153 }, "type" : "ARROW", "centre" : { "x" : 1185, "y" : 153 } } } ] }, { "id" : 113204, "reactomeId" : 10022847, "displayName" : "p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 1264, "y" : 114 }, "minX" : 1174, "maxX" : 1335, "minY" : 69, "maxY" : 153, "prop" : { "x" : 1200, "y" : 75, "width" : 129, "height" : 78 }, "textPosition" : { "x" : 1201, "y" : 76 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1329, "y" : 75 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1329, "y" : 75 } } }, "connectors" : [ { "edgeId" : 113201, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 1197, "y" : 125 }, "to" : { "x" : 1174, "y" : 130 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1191, "y" : 130 }, "b" : { "x" : 1197, "y" : 125 }, "c" : { "x" : 1189, "y" : 123 }, "type" : "ARROW", "centre" : { "x" : 1189, "y" : 123 } } } ] }, { "id" : 113207, "reactomeId" : 10004534, "displayName" : "CHUK:IKBKB:IKBKG", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 1375, "y" : 215 }, "minX" : 1312, "maxX" : 1444, "minY" : 179, "maxY" : 226, "prop" : { "x" : 1312, "y" : 204, "width" : 126, "height" : 22 }, "textPosition" : { "x" : 1317, "y" : 205 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1438, "y" : 204 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1438, "y" : 204 } } }, "connectors" : [ { "edgeId" : 113206, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1386, "y" : 201 }, "to" : { "x" : 1411, "y" : 179 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 113208, "reactomeId" : 10022858, "displayName" : "TRAF6:K63-linked polyUb p-IRAK1:IKK complex", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 1435, "y" : 108 }, "minX" : 1370, "maxX" : 1506, "minY" : 77, "maxY" : 133, "prop" : { "x" : 1370, "y" : 83, "width" : 130, "height" : 50 }, "textPosition" : { "x" : 1372, "y" : 84 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1500, "y" : 83 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1500, "y" : 83 } } }, "connectors" : [ { "edgeId" : 113206, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 113210, "reactomeId" : 10018010, "displayName" : "TAK1 complex", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 853, "y" : 211 }, "minX" : 805, "maxX" : 907, "minY" : 129, "maxY" : 222, "prop" : { "x" : 805, "y" : 200, "width" : 96, "height" : 22 }, "textPosition" : { "x" : 806, "y" : 201 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 901, "y" : 200 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 901, "y" : 200 } } }, "connectors" : [ { "edgeId" : 113209, "type" : "INPUT", "segments" : [ { "from" : { "x" : 854, "y" : 197 }, "to" : { "x" : 865, "y" : 129 } } ], "stoichiometry" : { "value" : 3, "shape" : { "a" : { "x" : 853, "y" : 157 }, "b" : { "x" : 865, "y" : 169 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 859, "y" : 163 } } } } ] }, { "id" : 113213, "reactomeId" : 179856, "displayName" : "PI(4,5)P2", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 313, "y" : 108 }, "minX" : 277, "maxX" : 350, "minY" : 92, "maxY" : 140, "prop" : { "x" : 277, "y" : 93, "width" : 72, "height" : 30 }, "textPosition" : { "x" : 280, "y" : 97 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 344, "y" : 98 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 344, "y" : 98 } } }, "connectors" : [ { "edgeId" : 113211, "type" : "INPUT", "segments" : [ { "from" : { "x" : 302, "y" : 126 }, "to" : { "x" : 290, "y" : 140 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 113212, "reactomeId" : 10045761, "displayName" : "Tirap", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 310, "y" : 174 }, "minX" : 289, "maxX" : 338, "minY" : 140, "maxY" : 185, "prop" : { "x" : 289, "y" : 163, "width" : 43, "height" : 22 }, "textPosition" : { "x" : 291, "y" : 163 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 332, "y" : 163 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 332, "y" : 163 } } }, "connectors" : [ { "edgeId" : 113211, "type" : "INPUT", "segments" : [ { "from" : { "x" : 303, "y" : 160 }, "to" : { "x" : 290, "y" : 140 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 113214, "reactomeId" : 10045763, "displayName" : "TIRAP:PI(4,5)P2", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 212, "y" : 106 }, "minX" : 162, "maxX" : 268, "minY" : 89, "maxY" : 117, "prop" : { "x" : 162, "y" : 95, "width" : 100, "height" : 22 }, "textPosition" : { "x" : 168, "y" : 82 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 262, "y" : 95 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 262, "y" : 95 } } }, "connectors" : [ { "edgeId" : 113211, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] } ], "edges" : [ { "id" : 113201, "reactomeId" : 10022850, "displayName" : "Auto phosphorylation of TAK1 bound to p-IRAK2:pUb oligo-TRAF6: free K63 pUb:TAB1:TAB2/TAB3", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 1137, "y" : 130 }, "minX" : 1100, "maxX" : 1174, "minY" : 124, "maxY" : 136, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 1100, "y" : 131 }, "to" : { "x" : 1137, "y" : 130 } }, { "from" : { "x" : 1137, "y" : 130 }, "to" : { "x" : 1174, "y" : 130 } } ], "reactionShape" : { "a" : { "x" : 1131, "y" : 124 }, "b" : { "x" : 1143, "y" : 136 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1137, "y" : 130 } }, "inputs" : [ { "id" : 113202, "points" : [ { "x" : 1080, "y" : 154 } ], "stoichiometry" : 6 }, { "id" : 113203, "points" : [ { "x" : 1064, "y" : 123 } ] } ], "outputs" : [ { "id" : 113204, "points" : [ { "x" : 1197, "y" : 125 } ] }, { "id" : 113205, "points" : [ { "x" : 1183, "y" : 161 } ], "stoichiometry" : 6 } ], "catalysts" : [ { "id" : 113203, "points" : [ { "x" : 1064, "y" : 112 }, { "x" : 1124, "y" : 112 } ] } ] }, { "id" : 113184, "reactomeId" : 10022871, "displayName" : "Pellino binds hp-IRAK1:TRAF6", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 1490, "y" : 565 }, "minX" : 1484, "maxX" : 1509, "minY" : 537, "maxY" : 609, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 1490, "y" : 609 }, "to" : { "x" : 1490, "y" : 565 } }, { "from" : { "x" : 1490, "y" : 565 }, "to" : { "x" : 1509, "y" : 537 } } ], "endShape" : { "a" : { "x" : 1508, "y" : 545 }, "b" : { "x" : 1509, "y" : 537 }, "c" : { "x" : 1502, "y" : 540 }, "type" : "ARROW", "centre" : { "x" : 1502, "y" : 540 } }, "reactionShape" : { "c" : { "x" : 1490, "y" : 565 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 1490, "y" : 565 } }, "inputs" : [ { "id" : 113185, "points" : [ { "x" : 1508, "y" : 656 } ] }, { "id" : 113186, "points" : [ { "x" : 1441, "y" : 617 } ] } ], "outputs" : [ { "id" : 113187 } ] }, { "id" : 113188, "reactomeId" : 10022869, "displayName" : "IRAK1 phosphorylates Pellino", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 1494, "y" : 448 }, "minX" : 1459, "maxX" : 1500, "minY" : 431, "maxY" : 478, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 1495, "y" : 478 }, "to" : { "x" : 1494, "y" : 448 } }, { "from" : { "x" : 1494, "y" : 448 }, "to" : { "x" : 1459, "y" : 431 } } ], "endShape" : { "a" : { "x" : 1467, "y" : 430 }, "b" : { "x" : 1459, "y" : 431 }, "c" : { "x" : 1463, "y" : 438 }, "type" : "ARROW", "centre" : { "x" : 1463, "y" : 438 } }, "reactionShape" : { "a" : { "x" : 1488, "y" : 442 }, "b" : { "x" : 1500, "y" : 454 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1494, "y" : 448 } }, "inputs" : [ { "id" : 113189, "points" : [ { "x" : 1460, "y" : 481 } ] }, { "id" : 113187, "points" : [ { "x" : 1508, "y" : 495 } ] } ], "outputs" : [ { "id" : 113190 } ], "catalysts" : [ { "id" : 113187, "points" : [ { "x" : 1519, "y" : 495 }, { "x" : 1517, "y" : 452 } ] } ] }, { "id" : 113191, "reactomeId" : 10022874, "displayName" : "Pellino ubiquitinates hp-IRAK1", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 1484, "y" : 269 }, "minX" : 1478, "maxX" : 1490, "minY" : 243, "maxY" : 305, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 1484, "y" : 305 }, "to" : { "x" : 1484, "y" : 269 } }, { "from" : { "x" : 1484, "y" : 269 }, "to" : { "x" : 1484, "y" : 243 } } ], "reactionShape" : { "a" : { "x" : 1478, "y" : 263 }, "b" : { "x" : 1490, "y" : 275 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1484, "y" : 269 } }, "inputs" : [ { "id" : 113192, "points" : [ { "x" : 1425, "y" : 330 } ], "stoichiometry" : 2 }, { "id" : 113193, "points" : [ { "x" : 1435, "y" : 295 } ] }, { "id" : 113194, "points" : [ { "x" : 1521, "y" : 362 } ] } ], "outputs" : [ { "id" : 113186, "points" : [ { "x" : 1376, "y" : 617 }, { "x" : 1325, "y" : 602 }, { "x" : 1326, "y" : 244 } ] }, { "id" : 113195, "points" : [ { "x" : 1503, "y" : 213 } ] }, { "id" : 113193, "points" : [ { "x" : 1420, "y" : 267 } ] } ], "catalysts" : [ { "id" : 113194, "points" : [ { "x" : 1528, "y" : 362 }, { "x" : 1503, "y" : 271 } ] } ] }, { "id" : 113175, "reactomeId" : 9996721, "displayName" : "TRAF6 binds MEKK1", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 1194, "y" : 789 }, "minX" : 1164, "maxX" : 1229, "minY" : 783, "maxY" : 795, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 1164, "y" : 789 }, "to" : { "x" : 1194, "y" : 789 } }, { "from" : { "x" : 1194, "y" : 789 }, "to" : { "x" : 1229, "y" : 789 } } ], "endShape" : { "a" : { "x" : 1222, "y" : 793 }, "b" : { "x" : 1229, "y" : 789 }, "c" : { "x" : 1222, "y" : 785 }, "type" : "ARROW", "centre" : { "x" : 1222, "y" : 785 } }, "reactionShape" : { "c" : { "x" : 1194, "y" : 789 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 1194, "y" : 789 } }, "inputs" : [ { "id" : 113176, "points" : [ { "x" : 1119, "y" : 827 } ] }, { "id" : 113177, "points" : [ { "x" : 1111, "y" : 765 } ] } ], "outputs" : [ { "id" : 113178 } ], "activators" : [ { "id" : 113179, "points" : [ { "x" : 1194, "y" : 755 } ] } ] }, { "id" : 113206, "reactomeId" : 10022860, "displayName" : "NEMO subunit of IKK complex binds to activated IRAK1", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 1409, "y" : 155 }, "minX" : 1403, "maxX" : 1421, "minY" : 136, "maxY" : 179, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 1411, "y" : 179 }, "to" : { "x" : 1409, "y" : 155 } }, { "from" : { "x" : 1409, "y" : 155 }, "to" : { "x" : 1421, "y" : 136 } } ], "endShape" : { "a" : { "x" : 1421, "y" : 144 }, "b" : { "x" : 1421, "y" : 136 }, "c" : { "x" : 1414, "y" : 140 }, "type" : "ARROW", "centre" : { "x" : 1414, "y" : 140 } }, "reactionShape" : { "c" : { "x" : 1409, "y" : 155 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 1409, "y" : 155 } }, "inputs" : [ { "id" : 113195, "points" : [ { "x" : 1449, "y" : 184 } ] }, { "id" : 113207, "points" : [ { "x" : 1386, "y" : 201 } ] } ], "outputs" : [ { "id" : 113208 } ] }, { "id" : 113209, "reactomeId" : 10022838, "displayName" : "Activated TRAF6:p-IRAK2 interacts with TAK1 complex", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 893, "y" : 109 }, "minX" : 865, "maxX" : 927, "minY" : 103, "maxY" : 129, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 865, "y" : 129 }, "to" : { "x" : 893, "y" : 109 } }, { "from" : { "x" : 893, "y" : 109 }, "to" : { "x" : 927, "y" : 110 } } ], "endShape" : { "a" : { "x" : 920, "y" : 114 }, "b" : { "x" : 927, "y" : 110 }, "c" : { "x" : 920, "y" : 106 }, "type" : "ARROW", "centre" : { "x" : 920, "y" : 106 } }, "reactionShape" : { "c" : { "x" : 893, "y" : 109 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 893, "y" : 109 } }, "inputs" : [ { "id" : 113210, "points" : [ { "x" : 854, "y" : 197 } ], "stoichiometry" : 3 }, { "id" : 113198, "points" : [ { "x" : 814, "y" : 117 } ] }, { "id" : 113200, "points" : [ { "x" : 805, "y" : 146 } ], "stoichiometry" : 3 } ], "outputs" : [ { "id" : 113203 } ] }, { "id" : 113211, "reactomeId" : 10045765, "displayName" : "TIRAP binds PIP2-rich regions in the plasma membrane", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 251, "y" : 140 }, "minX" : 224, "maxX" : 290, "minY" : 120, "maxY" : 146, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 290, "y" : 140 }, "to" : { "x" : 251, "y" : 140 } }, { "from" : { "x" : 251, "y" : 140 }, "to" : { "x" : 224, "y" : 120 } } ], "endShape" : { "a" : { "x" : 232, "y" : 121 }, "b" : { "x" : 224, "y" : 120 }, "c" : { "x" : 227, "y" : 127 }, "type" : "ARROW", "centre" : { "x" : 227, "y" : 127 } }, "reactionShape" : { "c" : { "x" : 251, "y" : 140 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 251, "y" : 140 } }, "inputs" : [ { "id" : 113212, "points" : [ { "x" : 303, "y" : 160 } ] }, { "id" : 113213, "points" : [ { "x" : 302, "y" : 126 } ] } ], "outputs" : [ { "id" : 113214 } ] }, { "id" : 113180, "reactomeId" : 10022840, "displayName" : "IRAK2 induces TRAF6 oligomerization", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 492, "y" : 131 }, "minX" : 472, "maxX" : 518, "minY" : 117, "maxY" : 137, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 472, "y" : 133 }, "to" : { "x" : 492, "y" : 131 } }, { "from" : { "x" : 492, "y" : 131 }, "to" : { "x" : 518, "y" : 117 } } ], "endShape" : { "a" : { "x" : 514, "y" : 124 }, "b" : { "x" : 518, "y" : 117 }, "c" : { "x" : 510, "y" : 117 }, "type" : "ARROW", "centre" : { "x" : 510, "y" : 117 } }, "reactionShape" : { "c" : { "x" : 492, "y" : 131 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 492, "y" : 131 } }, "inputs" : [ { "id" : 113181, "points" : [ { "x" : 444, "y" : 118 } ] }, { "id" : 113182, "points" : [ { "x" : 463, "y" : 169 } ], "stoichiometry" : 2 } ], "outputs" : [ { "id" : 113183 } ] }, { "id" : 113196, "reactomeId" : 10022821, "displayName" : "Auto ubiquitination of oligo-TRAF6 bound to p-IRAK2", "schemaClass" : "BlackBoxEvent", "renderableClass" : "Reaction", "position" : { "x" : 657, "y" : 124 }, "minX" : 623, "maxX" : 691, "minY" : 117, "maxY" : 130, "reactionType" : "omitted", "segments" : [ { "from" : { "x" : 623, "y" : 124 }, "to" : { "x" : 657, "y" : 124 } }, { "from" : { "x" : 657, "y" : 124 }, "to" : { "x" : 691, "y" : 117 } } ], "endShape" : { "a" : { "x" : 685, "y" : 122 }, "b" : { "x" : 691, "y" : 117 }, "c" : { "x" : 683, "y" : 114 }, "type" : "ARROW", "centre" : { "x" : 683, "y" : 114 } }, "reactionShape" : { "a" : { "x" : 651, "y" : 118 }, "b" : { "x" : 663, "y" : 130 }, "s" : "\\\\", "type" : "BOX", "empty" : true, "centre" : { "x" : 657, "y" : 124 } }, "inputs" : [ { "id" : 113183, "points" : [ { "x" : 596, "y" : 113 } ] }, { "id" : 113197, "points" : [ { "x" : 603, "y" : 142 } ], "stoichiometry" : 9 } ], "outputs" : [ { "id" : 113198 } ], "catalysts" : [ { "id" : 113183, "points" : [ { "x" : 596, "y" : 96 }, { "x" : 652, "y" : 97 } ] } ] }, { "id" : 113199, "reactomeId" : 10022845, "displayName" : "Activated TRAF6 synthesizes unanchored polyubiquitin chains", "schemaClass" : "Polymerisation", "renderableClass" : "Reaction", "position" : { "x" : 662, "y" : 159 }, "minX" : 614, "maxX" : 732, "minY" : 153, "maxY" : 165, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 614, "y" : 159 }, "to" : { "x" : 662, "y" : 159 } }, { "from" : { "x" : 662, "y" : 159 }, "to" : { "x" : 732, "y" : 159 } } ], "endShape" : { "a" : { "x" : 725, "y" : 163 }, "b" : { "x" : 732, "y" : 159 }, "c" : { "x" : 725, "y" : 155 }, "type" : "ARROW", "centre" : { "x" : 725, "y" : 155 } }, "reactionShape" : { "c" : { "x" : 662, "y" : 159 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 662, "y" : 159 } }, "inputs" : [ { "id" : 113197 } ], "outputs" : [ { "id" : 113200 } ], "catalysts" : [ { "id" : 113198, "points" : [ { "x" : 727, "y" : 117 } ] } ] } ], "compartments" : [ { "id" : 113215, "reactomeId" : 70101, "displayName" : "cytosol", "schemaClass" : "Compartment", "renderableClass" : "Compartment", "position" : { "x" : 802, "y" : 545 }, "minX" : 93, "maxX" : 1511, "minY" : 104, "maxY" : 986, "prop" : { "x" : 93, "y" : 104, "width" : 1418, "height" : 882 }, "textPosition" : { "x" : 552, "y" : 553 }, "insets" : { "x" : 103, "y" : 114, "width" : 1398, "height" : 862 }, "bgColor" : { "r" : 250, "g" : 240, "b" : 240 }, "componentIds" : [ 113176, 113226, 113227, 113175, 113177, 113178, 113179, 113181, 113183, 113180, 113182, 113184, 113185, 113186, 113187, 113188, 113189, 113190, 113194, 113193, 113195, 113192, 113191, 113196, 113197, 113198, 113199, 113210, 113203, 113200, 113202, 113204, 113205, 113201, 113238, 113239, 113207, 113208, 113206, 113240, 113214, 113209, 113211, 113212, 113213 ] } ], "notes" : [ ], "links" : [ { "id" : 113239, "renderableClass" : "Interaction", "position" : { "x" : 1232, "y" : 281 }, "minX" : 1226, "maxX" : 1256, "minY" : 156, "maxY" : 294, "interactionType" : "Activate", "segments" : [ { "from" : { "x" : 1256, "y" : 156 }, "to" : { "x" : 1232, "y" : 281 } }, { "from" : { "x" : 1232, "y" : 281 }, "to" : { "x" : 1232, "y" : 294 } } ], "endShape" : { "a" : { "x" : 1228, "y" : 287 }, "b" : { "x" : 1232, "y" : 294 }, "c" : { "x" : 1236, "y" : 287 }, "type" : "ARROW", "empty" : true, "centre" : { "x" : 1236, "y" : 287 } }, "reactionShape" : { "a" : { "x" : 1226, "y" : 275 }, "b" : { "x" : 1238, "y" : 287 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1232, "y" : 281 } }, "inputs" : [ { "id" : 113204 } ], "outputs" : [ { "id" : 113227 } ] }, { "id" : 113238, "renderableClass" : "Interaction", "position" : { "x" : 1126, "y" : 311 }, "minX" : 1115, "maxX" : 1236, "minY" : 156, "maxY" : 321, "interactionType" : "Activate", "segments" : [ { "from" : { "x" : 1236, "y" : 156 }, "to" : { "x" : 1126, "y" : 311 } }, { "from" : { "x" : 1126, "y" : 311 }, "to" : { "x" : 1115, "y" : 321 } } ], "endShape" : { "a" : { "x" : 1117, "y" : 313 }, "b" : { "x" : 1115, "y" : 321 }, "c" : { "x" : 1123, "y" : 319 }, "type" : "ARROW", "empty" : true, "centre" : { "x" : 1123, "y" : 319 } }, "reactionShape" : { "a" : { "x" : 1120, "y" : 305 }, "b" : { "x" : 1132, "y" : 317 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1126, "y" : 311 } }, "inputs" : [ { "id" : 113204 } ], "outputs" : [ { "id" : 113226 } ] }, { "id" : 113240, "renderableClass" : "Interaction", "position" : { "x" : 1301, "y" : 200 }, "minX" : 1243, "maxX" : 1367, "minY" : 118, "maxY" : 294, "interactionType" : "Activate", "segments" : [ { "from" : { "x" : 1367, "y" : 118 }, "to" : { "x" : 1355, "y" : 121 } }, { "from" : { "x" : 1355, "y" : 121 }, "to" : { "x" : 1248, "y" : 280 } }, { "from" : { "x" : 1248, "y" : 280 }, "to" : { "x" : 1243, "y" : 294 } } ], "endShape" : { "a" : { "x" : 1242, "y" : 286 }, "b" : { "x" : 1243, "y" : 294 }, "c" : { "x" : 1249, "y" : 289 }, "type" : "ARROW", "empty" : true, "centre" : { "x" : 1249, "y" : 289 } }, "reactionShape" : { "a" : { "x" : 1295, "y" : 194 }, "b" : { "x" : 1307, "y" : 206 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1301, "y" : 200 } }, "inputs" : [ { "id" : 113208 } ], "outputs" : [ { "id" : 113227 } ] } ], "shadows" : [ { "id" : 113241, "reactomeId" : 10100525, "displayName" : "IRAK2 mediated activation of TAK1 complex", "schemaClass" : "Pathway", "renderableClass" : "Shadow", "position" : { "x" : 853, "y" : 148 }, "minX" : 368, "maxX" : 1339, "minY" : 65, "maxY" : 232, "prop" : { "x" : 368, "y" : 73, "width" : 934, "height" : 159 }, "points" : [ { "x" : 368, "y" : 65 }, { "x" : 1339, "y" : 65 }, { "x" : 1339, "y" : 232 }, { "x" : 368, "y" : 232 } ], "colour" : "#4684ee" }, { "id" : 113242, "reactomeId" : 10100527, "displayName" : "IRAK1 recruits IKK complex", "schemaClass" : "Pathway", "renderableClass" : "Shadow", "position" : { "x" : 1454, "y" : 382 }, "minX" : 1302, "maxX" : 1606, "minY" : 73, "maxY" : 691, "prop" : { "x" : 1302, "y" : 232, "width" : 304, "height" : 459 }, "points" : [ { "x" : 1302, "y" : 73 }, { "x" : 1606, "y" : 73 }, { "x" : 1606, "y" : 691 }, { "x" : 1302, "y" : 691 } ], "colour" : "#dc3912" } ], "minX" : 0, "maxX" : 1602, "minY" : 0, "maxY" : 986, "disease" : false }