{
  "dbId" : 10099263,
  "stableId" : "R-MMU-166166",
  "displayName" : "MyD88-independent TLR4 cascade ",
  "nodes" : [ {
    "id" : 52869,
    "reactomeId" : 9996501,
    "displayName" : "TRAM:TLR4:LY96:LPS:CD14",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 481,
      "y" : 175
    },
    "minX" : 424,
    "maxX" : 556,
    "minY" : 144,
    "maxY" : 194,
    "prop" : {
      "x" : 424,
      "y" : 157,
      "width" : 114,
      "height" : 37
    },
    "textPosition" : {
      "x" : 425,
      "y" : 159
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "fgColor" : {
      "r" : 0,
      "g" : 0,
      "b" : 0
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 538,
          "y" : 157
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 538,
          "y" : 157
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 52868,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 525,
          "y" : 154
        },
        "to" : {
          "x" : 556,
          "y" : 144
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 52870,
    "reactomeId" : 9996507,
    "displayName" : "Ticam1",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 468,
      "y" : 127
    },
    "minX" : 441,
    "maxX" : 556,
    "minY" : 110,
    "maxY" : 144,
    "prop" : {
      "x" : 441,
      "y" : 116,
      "width" : 54,
      "height" : 23
    },
    "textPosition" : {
      "x" : 442,
      "y" : 117
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 495,
          "y" : 116
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 495,
          "y" : 116
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 52868,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 498,
          "y" : 132
        },
        "to" : {
          "x" : 556,
          "y" : 144
        }
      } ],
      "stoichiometry" : {
        "value" : 2,
        "shape" : {
          "a" : {
            "x" : 521,
            "y" : 132
          },
          "b" : {
            "x" : 533,
            "y" : 144
          },
          "type" : "BOX",
          "empty" : true,
          "centre" : {
            "x" : 527,
            "y" : 138
          }
        }
      }
    } ]
  }, {
    "id" : 52871,
    "reactomeId" : 9996509,
    "displayName" : "TICAM1:TRAM:TLR4:LY96:LPS:CD14",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 676,
      "y" : 183
    },
    "minX" : 70,
    "maxX" : 798,
    "minY" : 77,
    "maxY" : 1006,
    "prop" : {
      "x" : 611,
      "y" : 165,
      "width" : 130,
      "height" : 37
    },
    "textPosition" : {
      "x" : 613,
      "y" : 167
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "fgColor" : {
      "r" : 0,
      "g" : 0,
      "b" : 0
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 741,
          "y" : 165
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 741,
          "y" : 165
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 52868,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 52877,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 608,
          "y" : 193
        },
        "to" : {
          "x" : 121,
          "y" : 270
        }
      }, {
        "from" : {
          "x" : 121,
          "y" : 270
        },
        "to" : {
          "x" : 70,
          "y" : 337
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 52897,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 744,
          "y" : 165
        },
        "to" : {
          "x" : 798,
          "y" : 150
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 52911,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 668,
          "y" : 205
        },
        "to" : {
          "x" : 346,
          "y" : 1006
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 669,
          "y" : 213
        },
        "b" : {
          "x" : 668,
          "y" : 205
        },
        "c" : {
          "x" : 662,
          "y" : 210
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 662,
          "y" : 210
        }
      }
    }, {
      "edgeId" : 52913,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 697,
          "y" : 162
        },
        "to" : {
          "x" : 778,
          "y" : 97
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 52919,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 671,
          "y" : 162
        },
        "to" : {
          "x" : 648,
          "y" : 77
        }
      }, {
        "from" : {
          "x" : 648,
          "y" : 77
        },
        "to" : {
          "x" : 140,
          "y" : 77
        }
      }, {
        "from" : {
          "x" : 140,
          "y" : 77
        },
        "to" : {
          "x" : 100,
          "y" : 188
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 52873,
    "reactomeId" : 9996560,
    "displayName" : "activated TLR4:TRIF:K63polyUb-TRAF3:K63polyUb-TANK:p-TBK1/p-IKBKE",
    "schemaClass" : "DefinedSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 1460,
      "y" : 797
    },
    "minX" : 1396,
    "maxX" : 1725,
    "minY" : 750,
    "maxY" : 856,
    "prop" : {
      "x" : 1396,
      "y" : 765,
      "width" : 128,
      "height" : 65
    },
    "textPosition" : {
      "x" : 1400,
      "y" : 759
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "fgColor" : {
      "r" : 0,
      "g" : 0,
      "b" : 0
    },
    "connectors" : [ {
      "edgeId" : 52872,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1530,
          "y" : 819
        },
        "to" : {
          "x" : 1541,
          "y" : 825
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 52887,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 1530,
          "y" : 773
        },
        "to" : {
          "x" : 1585,
          "y" : 751
        }
      }, {
        "from" : {
          "x" : 1585,
          "y" : 751
        },
        "to" : {
          "x" : 1723,
          "y" : 750
        }
      }, {
        "from" : {
          "x" : 1723,
          "y" : 750
        },
        "to" : {
          "x" : 1725,
          "y" : 856
        }
      }, {
        "from" : {
          "x" : 1725,
          "y" : 856
        },
        "to" : {
          "x" : 1692,
          "y" : 856
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 1535,
          "y" : 767
        },
        "b" : {
          "x" : 1530,
          "y" : 773
        },
        "c" : {
          "x" : 1538,
          "y" : 774
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 1538,
          "y" : 774
        }
      }
    } ]
  }, {
    "id" : 52874,
    "reactomeId" : 9996569,
    "displayName" : "IRF3,IRF7",
    "schemaClass" : "DefinedSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 1576,
      "y" : 784
    },
    "minX" : 1541,
    "maxX" : 1608,
    "minY" : 773,
    "maxY" : 825,
    "prop" : {
      "x" : 1545,
      "y" : 773,
      "width" : 63,
      "height" : 23
    },
    "textPosition" : {
      "x" : 1557,
      "y" : 767
    },
    "connectors" : [ {
      "edgeId" : 52872,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1566,
          "y" : 802
        },
        "to" : {
          "x" : 1541,
          "y" : 825
        }
      } ],
      "stoichiometry" : {
        "value" : 2,
        "shape" : {
          "a" : {
            "x" : 1547,
            "y" : 807
          },
          "b" : {
            "x" : 1559,
            "y" : 819
          },
          "type" : "BOX",
          "empty" : true,
          "centre" : {
            "x" : 1553,
            "y" : 813
          }
        }
      }
    } ]
  }, {
    "id" : 52875,
    "reactomeId" : 9996571,
    "displayName" : "activated TLR4:TRIF:K63polyUb-TRAF3:K63polyUb-TANK:p-TBK1/p-IKBKE:IRF3/IRF7",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 1457,
      "y" : 878
    },
    "minX" : 1393,
    "maxX" : 1673,
    "minY" : 833,
    "maxY" : 918,
    "prop" : {
      "x" : 1393,
      "y" : 839,
      "width" : 128,
      "height" : 79
    },
    "textPosition" : {
      "x" : 1397,
      "y" : 841
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "fgColor" : {
      "r" : 0,
      "g" : 0,
      "b" : 0
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1521,
          "y" : 839
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1521,
          "y" : 839
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 52872,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 52887,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1524,
          "y" : 870
        },
        "to" : {
          "x" : 1644,
          "y" : 856
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 52887,
      "type" : "CATALYST",
      "segments" : [ {
        "from" : {
          "x" : 1524,
          "y" : 877
        },
        "to" : {
          "x" : 1669,
          "y" : 875
        }
      }, {
        "from" : {
          "x" : 1669,
          "y" : 875
        },
        "to" : {
          "x" : 1669,
          "y" : 872
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 1669,
          "y" : 868
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1669,
          "y" : 868
        }
      }
    } ]
  }, {
    "id" : 52876,
    "reactomeId" : 9996589,
    "displayName" : "PTPN11",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 1589,
      "y" : 838
    },
    "minX" : 1551,
    "maxX" : 1623,
    "minY" : 821,
    "maxY" : 850,
    "prop" : {
      "x" : 1561,
      "y" : 827,
      "width" : 56,
      "height" : 23
    },
    "textPosition" : {
      "x" : 1561,
      "y" : 828
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1617,
          "y" : 827
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1617,
          "y" : 827
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 52872,
      "type" : "INHIBITOR",
      "segments" : [ {
        "from" : {
          "x" : 1558,
          "y" : 840
        },
        "to" : {
          "x" : 1552,
          "y" : 841
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 1551,
          "y" : 837
        },
        "b" : {
          "x" : 1553,
          "y" : 845
        },
        "c" : {
          "x" : 1552,
          "y" : 841
        },
        "type" : "STOP",
        "centre" : {
          "x" : 1552,
          "y" : 841
        }
      }
    } ]
  }, {
    "id" : 52878,
    "reactomeId" : 9990970,
    "displayName" : "RIPK1",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 58,
      "y" : 278
    },
    "minX" : 37,
    "maxX" : 86,
    "minY" : 261,
    "maxY" : 337,
    "prop" : {
      "x" : 37,
      "y" : 267,
      "width" : 43,
      "height" : 23
    },
    "textPosition" : {
      "x" : 37,
      "y" : 268
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 80,
          "y" : 267
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 80,
          "y" : 267
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 52877,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 60,
          "y" : 293
        },
        "to" : {
          "x" : 70,
          "y" : 337
        }
      } ],
      "stoichiometry" : {
        "value" : 2,
        "shape" : {
          "a" : {
            "x" : 59,
            "y" : 309
          },
          "b" : {
            "x" : 71,
            "y" : 321
          },
          "type" : "BOX",
          "empty" : true,
          "centre" : {
            "x" : 65,
            "y" : 315
          }
        }
      }
    } ]
  }, {
    "id" : 52879,
    "reactomeId" : 9997019,
    "displayName" : "RIP1:TICAM1:TRAM:TLR4:LY96:LPS:CD14",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 164,
      "y" : 535
    },
    "minX" : 81,
    "maxX" : 233,
    "minY" : 504,
    "maxY" : 584,
    "prop" : {
      "x" : 101,
      "y" : 510,
      "width" : 126,
      "height" : 51
    },
    "textPosition" : {
      "x" : 102,
      "y" : 512
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "fgColor" : {
      "r" : 0,
      "g" : 0,
      "b" : 0
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 227,
          "y" : 510
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 227,
          "y" : 510
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 52877,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 52890,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 98,
          "y" : 544
        },
        "to" : {
          "x" : 81,
          "y" : 547
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 52921,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 156,
          "y" : 564
        },
        "to" : {
          "x" : 150,
          "y" : 584
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 52880,
    "reactomeId" : 9997064,
    "displayName" : "RIPK3",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 122,
      "y" : 330
    },
    "minX" : 76,
    "maxX" : 174,
    "minY" : 313,
    "maxY" : 357,
    "prop" : {
      "x" : 101,
      "y" : 319,
      "width" : 43,
      "height" : 23
    },
    "textPosition" : {
      "x" : 101,
      "y" : 320
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 144,
          "y" : 319
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 144,
          "y" : 319
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 52928,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 147,
          "y" : 341
        },
        "to" : {
          "x" : 174,
          "y" : 357
        }
      } ],
      "stoichiometry" : {
        "value" : 4,
        "shape" : {
          "a" : {
            "x" : 154,
            "y" : 343
          },
          "b" : {
            "x" : 166,
            "y" : 355
          },
          "type" : "BOX",
          "empty" : true,
          "centre" : {
            "x" : 160,
            "y" : 349
          }
        }
      }
    }, {
      "edgeId" : 52877,
      "type" : "INHIBITOR",
      "segments" : [ {
        "from" : {
          "x" : 98,
          "y" : 341
        },
        "to" : {
          "x" : 78,
          "y" : 354
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 76,
          "y" : 351
        },
        "b" : {
          "x" : 80,
          "y" : 357
        },
        "c" : {
          "x" : 78,
          "y" : 354
        },
        "type" : "STOP",
        "centre" : {
          "x" : 78,
          "y" : 354
        }
      }
    } ]
  }, {
    "id" : 52881,
    "reactomeId" : 9997060,
    "displayName" : "SARM:TICAM1:TRAM:TLR4:LY96:LPS:CD14",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 186,
      "y" : 207
    },
    "minX" : 27,
    "maxX" : 1043,
    "minY" : 39,
    "maxY" : 363,
    "prop" : {
      "x" : 129,
      "y" : 182,
      "width" : 114,
      "height" : 51
    },
    "textPosition" : {
      "x" : 130,
      "y" : 184
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 243,
          "y" : 182
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 243,
          "y" : 182
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 52877,
      "type" : "INHIBITOR",
      "segments" : [ {
        "from" : {
          "x" : 126,
          "y" : 217
        },
        "to" : {
          "x" : 27,
          "y" : 235
        }
      }, {
        "from" : {
          "x" : 27,
          "y" : 235
        },
        "to" : {
          "x" : 27,
          "y" : 358
        }
      }, {
        "from" : {
          "x" : 27,
          "y" : 358
        },
        "to" : {
          "x" : 61,
          "y" : 359
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 61,
          "y" : 363
        },
        "b" : {
          "x" : 61,
          "y" : 355
        },
        "c" : {
          "x" : 61,
          "y" : 359
        },
        "type" : "STOP",
        "centre" : {
          "x" : 61,
          "y" : 359
        }
      }
    }, {
      "edgeId" : 52897,
      "type" : "INHIBITOR",
      "segments" : [ {
        "from" : {
          "x" : 184,
          "y" : 179
        },
        "to" : {
          "x" : 174,
          "y" : 54
        }
      }, {
        "from" : {
          "x" : 174,
          "y" : 54
        },
        "to" : {
          "x" : 828,
          "y" : 55
        }
      }, {
        "from" : {
          "x" : 828,
          "y" : 55
        },
        "to" : {
          "x" : 828,
          "y" : 141
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 824,
          "y" : 141
        },
        "b" : {
          "x" : 832,
          "y" : 141
        },
        "c" : {
          "x" : 828,
          "y" : 141
        },
        "type" : "STOP",
        "centre" : {
          "x" : 828,
          "y" : 141
        }
      }
    }, {
      "edgeId" : 52913,
      "type" : "INHIBITOR",
      "segments" : [ {
        "from" : {
          "x" : 183,
          "y" : 179
        },
        "to" : {
          "x" : 171,
          "y" : 39
        }
      }, {
        "from" : {
          "x" : 171,
          "y" : 39
        },
        "to" : {
          "x" : 1038,
          "y" : 39
        }
      }, {
        "from" : {
          "x" : 1038,
          "y" : 39
        },
        "to" : {
          "x" : 1039,
          "y" : 88
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 1035,
          "y" : 88
        },
        "b" : {
          "x" : 1043,
          "y" : 88
        },
        "c" : {
          "x" : 1039,
          "y" : 88
        },
        "type" : "STOP",
        "centre" : {
          "x" : 1039,
          "y" : 88
        }
      }
    }, {
      "edgeId" : 52919,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 52883,
    "reactomeId" : 9996584,
    "displayName" : "p-4S,T404-IRF3,p-S477,S479-IRF7",
    "schemaClass" : "DefinedSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 1693,
      "y" : 929
    },
    "minX" : 1631,
    "maxX" : 1756,
    "minY" : 856,
    "maxY" : 979,
    "prop" : {
      "x" : 1631,
      "y" : 911,
      "width" : 125,
      "height" : 37
    },
    "textPosition" : {
      "x" : 1635,
      "y" : 912
    },
    "connectors" : [ {
      "edgeId" : 52882,
      "type" : "INPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 2,
        "shape" : {
          "a" : {
            "x" : 1687,
            "y" : 967
          },
          "b" : {
            "x" : 1699,
            "y" : 979
          },
          "type" : "BOX",
          "empty" : true,
          "centre" : {
            "x" : 1693,
            "y" : 973
          }
        }
      }
    }, {
      "edgeId" : 52887,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 1692,
          "y" : 905
        },
        "to" : {
          "x" : 1692,
          "y" : 856
        }
      } ],
      "stoichiometry" : {
        "value" : 2,
        "shape" : {
          "a" : {
            "x" : 1686,
            "y" : 874
          },
          "b" : {
            "x" : 1698,
            "y" : 886
          },
          "type" : "BOX",
          "empty" : true,
          "centre" : {
            "x" : 1692,
            "y" : 880
          }
        }
      },
      "endShape" : {
        "a" : {
          "x" : 1688,
          "y" : 898
        },
        "b" : {
          "x" : 1692,
          "y" : 905
        },
        "c" : {
          "x" : 1696,
          "y" : 898
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 1696,
          "y" : 898
        }
      }
    } ]
  }, {
    "id" : 52884,
    "reactomeId" : 9997074,
    "displayName" : "phosphorylated IRF3 and/or IRF7 dimer",
    "schemaClass" : "DefinedSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 1669,
      "y" : 1037
    },
    "minX" : 1603,
    "maxX" : 1735,
    "minY" : 1019,
    "maxY" : 1056,
    "prop" : {
      "x" : 1603,
      "y" : 1019,
      "width" : 132,
      "height" : 37
    },
    "textPosition" : {
      "x" : 1612,
      "y" : 1013
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "connectors" : [ {
      "edgeId" : 52882,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 52885,
      "type" : "INPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 52886,
    "reactomeId" : 9999608,
    "displayName" : "phosphorylated IRF3 and/or IRF7 dimer",
    "schemaClass" : "DefinedSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 1665,
      "y" : 1138
    },
    "minX" : 1599,
    "maxX" : 1731,
    "minY" : 1120,
    "maxY" : 1157,
    "prop" : {
      "x" : 1599,
      "y" : 1120,
      "width" : 132,
      "height" : 37
    },
    "textPosition" : {
      "x" : 1608,
      "y" : 1114
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "connectors" : [ {
      "edgeId" : 52885,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 52888,
    "reactomeId" : 113592,
    "displayName" : "ATP",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 1644,
      "y" : 803
    },
    "minX" : 1624,
    "maxX" : 1665,
    "minY" : 787,
    "maxY" : 856,
    "prop" : {
      "x" : 1624,
      "y" : 788,
      "width" : 40,
      "height" : 31
    },
    "textPosition" : {
      "x" : 1628,
      "y" : 793
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1659,
          "y" : 793
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1659,
          "y" : 793
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 52887,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1644,
          "y" : 822
        },
        "to" : {
          "x" : 1644,
          "y" : 856
        }
      } ],
      "stoichiometry" : {
        "value" : 6,
        "shape" : {
          "a" : {
            "x" : 1638,
            "y" : 833
          },
          "b" : {
            "x" : 1650,
            "y" : 845
          },
          "type" : "BOX",
          "empty" : true,
          "centre" : {
            "x" : 1644,
            "y" : 839
          }
        }
      }
    } ]
  }, {
    "id" : 52889,
    "reactomeId" : 29370,
    "displayName" : "ADP",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 1694,
      "y" : 803
    },
    "minX" : 1674,
    "maxX" : 1716,
    "minY" : 787,
    "maxY" : 856,
    "prop" : {
      "x" : 1674,
      "y" : 788,
      "width" : 41,
      "height" : 31
    },
    "textPosition" : {
      "x" : 1678,
      "y" : 793
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1710,
          "y" : 793
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1710,
          "y" : 793
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 52887,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 1693,
          "y" : 822
        },
        "to" : {
          "x" : 1692,
          "y" : 856
        }
      } ],
      "stoichiometry" : {
        "value" : 6,
        "shape" : {
          "a" : {
            "x" : 1686,
            "y" : 833
          },
          "b" : {
            "x" : 1698,
            "y" : 845
          },
          "type" : "BOX",
          "empty" : true,
          "centre" : {
            "x" : 1692,
            "y" : 839
          }
        }
      },
      "endShape" : {
        "a" : {
          "x" : 1697,
          "y" : 829
        },
        "b" : {
          "x" : 1693,
          "y" : 822
        },
        "c" : {
          "x" : 1689,
          "y" : 829
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 1689,
          "y" : 829
        }
      }
    } ]
  }, {
    "id" : 52891,
    "reactomeId" : 9997017,
    "displayName" : "K63polyUb",
    "schemaClass" : "Polymer",
    "renderableClass" : "Entity",
    "position" : {
      "x" : 59,
      "y" : 493
    },
    "minX" : 23,
    "maxX" : 96,
    "minY" : 482,
    "maxY" : 547,
    "prop" : {
      "x" : 23,
      "y" : 482,
      "width" : 73,
      "height" : 23
    },
    "textPosition" : {
      "x" : 23,
      "y" : 483
    },
    "connectors" : [ {
      "edgeId" : 52890,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 63,
          "y" : 508
        },
        "to" : {
          "x" : 81,
          "y" : 547
        }
      } ],
      "stoichiometry" : {
        "value" : 2,
        "shape" : {
          "a" : {
            "x" : 66,
            "y" : 521
          },
          "b" : {
            "x" : 78,
            "y" : 533
          },
          "type" : "BOX",
          "empty" : true,
          "centre" : {
            "x" : 72,
            "y" : 527
          }
        }
      }
    } ]
  }, {
    "id" : 52892,
    "reactomeId" : 9997023,
    "displayName" : "K63pUb-RIP1:TICAM1:TRAM:TLR4:LY96:LPS:CD14",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 190,
      "y" : 854
    },
    "minX" : 125,
    "maxX" : 305,
    "minY" : 599,
    "maxY" : 944,
    "prop" : {
      "x" : 125,
      "y" : 829,
      "width" : 130,
      "height" : 51
    },
    "textPosition" : {
      "x" : 127,
      "y" : 831
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "fgColor" : {
      "r" : 0,
      "g" : 0,
      "b" : 0
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 255,
          "y" : 829
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 255,
          "y" : 829
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 52890,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 52894,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 182,
          "y" : 883
        },
        "to" : {
          "x" : 162,
          "y" : 944
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 52921,
      "type" : "INHIBITOR",
      "segments" : [ {
        "from" : {
          "x" : 258,
          "y" : 853
        },
        "to" : {
          "x" : 305,
          "y" : 853
        }
      }, {
        "from" : {
          "x" : 305,
          "y" : 853
        },
        "to" : {
          "x" : 305,
          "y" : 602
        }
      }, {
        "from" : {
          "x" : 305,
          "y" : 602
        },
        "to" : {
          "x" : 159,
          "y" : 603
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 159,
          "y" : 599
        },
        "b" : {
          "x" : 159,
          "y" : 607
        },
        "c" : {
          "x" : 159,
          "y" : 603
        },
        "type" : "STOP",
        "centre" : {
          "x" : 159,
          "y" : 603
        }
      }
    } ]
  }, {
    "id" : 52893,
    "reactomeId" : 9997051,
    "displayName" : "RIP1 ubiqutin ligases",
    "schemaClass" : "CandidateSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 97,
      "y" : 910
    },
    "minX" : 33,
    "maxX" : 162,
    "minY" : 857,
    "maxY" : 922,
    "prop" : {
      "x" : 33,
      "y" : 899,
      "width" : 129,
      "height" : 23
    },
    "textPosition" : {
      "x" : 50,
      "y" : 893
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "connectors" : [ {
      "edgeId" : 52890,
      "type" : "CATALYST",
      "segments" : [ {
        "from" : {
          "x" : 84,
          "y" : 893
        },
        "to" : {
          "x" : 47,
          "y" : 864
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 43,
          "y" : 861
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 43,
          "y" : 861
        }
      }
    } ]
  }, {
    "id" : 52895,
    "reactomeId" : 10004534,
    "displayName" : "CHUK:IKBKB:IKBKG",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 88,
      "y" : 948
    },
    "minX" : 29,
    "maxX" : 162,
    "minY" : 931,
    "maxY" : 960,
    "prop" : {
      "x" : 29,
      "y" : 937,
      "width" : 118,
      "height" : 23
    },
    "textPosition" : {
      "x" : 30,
      "y" : 939
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 147,
          "y" : 937
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 147,
          "y" : 937
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 52894,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 150,
          "y" : 944
        },
        "to" : {
          "x" : 162,
          "y" : 944
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 52896,
    "reactomeId" : 10022852,
    "displayName" : "CHUK:IKBKB:IKBKG:K63pUb-RIP1:TICAM1:TRAM:TLR4:LY96:LPS:CD14",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 176,
      "y" : 1014
    },
    "minX" : 111,
    "maxX" : 247,
    "minY" : 976,
    "maxY" : 1047,
    "prop" : {
      "x" : 111,
      "y" : 982,
      "width" : 130,
      "height" : 65
    },
    "textPosition" : {
      "x" : 113,
      "y" : 984
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "fgColor" : {
      "r" : 0,
      "g" : 0,
      "b" : 0
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 241,
          "y" : 982
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 241,
          "y" : 982
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 52894,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 52898,
    "reactomeId" : 9996713,
    "displayName" : "Traf6",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 795,
      "y" : 120
    },
    "minX" : 772,
    "maxX" : 825,
    "minY" : 103,
    "maxY" : 150,
    "prop" : {
      "x" : 772,
      "y" : 109,
      "width" : 47,
      "height" : 23
    },
    "textPosition" : {
      "x" : 775,
      "y" : 110
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 819,
          "y" : 109
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 819,
          "y" : 109
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 52897,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 796,
          "y" : 135
        },
        "to" : {
          "x" : 798,
          "y" : 150
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 52899,
    "reactomeId" : 10022832,
    "displayName" : "TRAF6:TICAM1:TRAM:TLR4:LY96:LPS:CD14",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 888,
      "y" : 197
    },
    "minX" : 831,
    "maxX" : 965,
    "minY" : 156,
    "maxY" : 223,
    "prop" : {
      "x" : 831,
      "y" : 172,
      "width" : 114,
      "height" : 51
    },
    "textPosition" : {
      "x" : 832,
      "y" : 174
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "fgColor" : {
      "r" : 0,
      "g" : 0,
      "b" : 0
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 945,
          "y" : 172
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 945,
          "y" : 172
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 52897,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 52900,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 935,
          "y" : 169
        },
        "to" : {
          "x" : 965,
          "y" : 156
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 52901,
    "reactomeId" : 9985374,
    "displayName" : "Ub",
    "schemaClass" : "DefinedSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 919,
      "y" : 126
    },
    "minX" : 907,
    "maxX" : 965,
    "minY" : 115,
    "maxY" : 156,
    "prop" : {
      "x" : 907,
      "y" : 115,
      "width" : 25,
      "height" : 23
    },
    "textPosition" : {
      "x" : 907,
      "y" : 116
    },
    "connectors" : [ {
      "edgeId" : 52900,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 938,
          "y" : 134
        },
        "to" : {
          "x" : 965,
          "y" : 156
        }
      } ],
      "stoichiometry" : {
        "value" : 3,
        "shape" : {
          "a" : {
            "x" : 945,
            "y" : 139
          },
          "b" : {
            "x" : 957,
            "y" : 151
          },
          "type" : "BOX",
          "empty" : true,
          "centre" : {
            "x" : 951,
            "y" : 145
          }
        }
      }
    } ]
  }, {
    "id" : 52902,
    "reactomeId" : 10018716,
    "displayName" : "K63-pUb-TRAF6:TICAM1:TRAM:TLR4:LY96:LPS:CD14",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 809,
      "y" : 1056
    },
    "minX" : 737,
    "maxX" : 880,
    "minY" : 1025,
    "maxY" : 1102,
    "prop" : {
      "x" : 744,
      "y" : 1031,
      "width" : 130,
      "height" : 51
    },
    "textPosition" : {
      "x" : 746,
      "y" : 1033
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "fgColor" : {
      "r" : 0,
      "g" : 0,
      "b" : 0
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 874,
          "y" : 1031
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 874,
          "y" : 1031
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 52900,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 52903,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 769,
          "y" : 1085
        },
        "to" : {
          "x" : 737,
          "y" : 1102
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 52904,
    "reactomeId" : 10018010,
    "displayName" : "TAK1 complex",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 754,
      "y" : 1149
    },
    "minX" : 697,
    "maxX" : 817,
    "minY" : 1102,
    "maxY" : 1168,
    "prop" : {
      "x" : 697,
      "y" : 1131,
      "width" : 114,
      "height" : 37
    },
    "textPosition" : {
      "x" : 707,
      "y" : 1147
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 811,
          "y" : 1131
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 811,
          "y" : 1131
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 52903,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 747,
          "y" : 1128
        },
        "to" : {
          "x" : 737,
          "y" : 1102
        }
      } ],
      "stoichiometry" : {
        "value" : 2,
        "shape" : {
          "a" : {
            "x" : 736,
            "y" : 1109
          },
          "b" : {
            "x" : 748,
            "y" : 1121
          },
          "type" : "BOX",
          "empty" : true,
          "centre" : {
            "x" : 742,
            "y" : 1115
          }
        }
      }
    } ]
  }, {
    "id" : 52905,
    "reactomeId" : 9997017,
    "displayName" : "K63polyUb",
    "schemaClass" : "Polymer",
    "renderableClass" : "Entity",
    "position" : {
      "x" : 1514,
      "y" : 1111
    },
    "minX" : 737,
    "maxX" : 1551,
    "minY" : 1100,
    "maxY" : 1123,
    "prop" : {
      "x" : 1478,
      "y" : 1100,
      "width" : 73,
      "height" : 23
    },
    "textPosition" : {
      "x" : 1478,
      "y" : 1101
    },
    "connectors" : [ {
      "edgeId" : 52937,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 52903,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1475,
          "y" : 1110
        },
        "to" : {
          "x" : 800,
          "y" : 1109
        }
      }, {
        "from" : {
          "x" : 800,
          "y" : 1109
        },
        "to" : {
          "x" : 737,
          "y" : 1102
        }
      } ],
      "stoichiometry" : {
        "value" : 2,
        "shape" : {
          "a" : {
            "x" : 1131,
            "y" : 1103
          },
          "b" : {
            "x" : 1143,
            "y" : 1115
          },
          "type" : "BOX",
          "empty" : true,
          "centre" : {
            "x" : 1137,
            "y" : 1109
          }
        }
      }
    } ]
  }, {
    "id" : 52906,
    "reactomeId" : 10022823,
    "displayName" : "activated TLR4:TICAM1:K63pUb-TRAF6:free K63pUb:TAK1complex",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 655,
      "y" : 1058
    },
    "minX" : 565,
    "maxX" : 726,
    "minY" : 1020,
    "maxY" : 1113,
    "prop" : {
      "x" : 590,
      "y" : 1026,
      "width" : 130,
      "height" : 65
    },
    "textPosition" : {
      "x" : 601,
      "y" : 1014
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "fgColor" : {
      "r" : 0,
      "g" : 0,
      "b" : 0
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 720,
          "y" : 1026
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 720,
          "y" : 1026
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 52903,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 52907,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 615,
          "y" : 1094
        },
        "to" : {
          "x" : 588,
          "y" : 1113
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 52907,
      "type" : "CATALYST",
      "segments" : [ {
        "from" : {
          "x" : 587,
          "y" : 1083
        },
        "to" : {
          "x" : 569,
          "y" : 1092
        }
      }, {
        "from" : {
          "x" : 569,
          "y" : 1092
        },
        "to" : {
          "x" : 569,
          "y" : 1097
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 569,
          "y" : 1101
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 569,
          "y" : 1101
        }
      }
    } ]
  }, {
    "id" : 52908,
    "reactomeId" : 113592,
    "displayName" : "ATP",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 630,
      "y" : 1150
    },
    "minX" : 588,
    "maxX" : 651,
    "minY" : 1113,
    "maxY" : 1166,
    "prop" : {
      "x" : 610,
      "y" : 1135,
      "width" : 40,
      "height" : 31
    },
    "textPosition" : {
      "x" : 614,
      "y" : 1140
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "fgColor" : {
      "r" : 0,
      "g" : 0,
      "b" : 0
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 645,
          "y" : 1140
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 645,
          "y" : 1140
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 52907,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 612,
          "y" : 1132
        },
        "to" : {
          "x" : 588,
          "y" : 1113
        }
      } ],
      "stoichiometry" : {
        "value" : 4,
        "shape" : {
          "a" : {
            "x" : 594,
            "y" : 1116
          },
          "b" : {
            "x" : 606,
            "y" : 1128
          },
          "type" : "BOX",
          "empty" : true,
          "centre" : {
            "x" : 600,
            "y" : 1122
          }
        }
      }
    } ]
  }, {
    "id" : 52909,
    "reactomeId" : 10022827,
    "displayName" : "activated TLR4:TICAM1:K63pUb-TRAF6:free K63pUb:activated TAK1 complex",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 482,
      "y" : 1051
    },
    "minX" : 417,
    "maxX" : 553,
    "minY" : 1006,
    "maxY" : 1113,
    "prop" : {
      "x" : 417,
      "y" : 1012,
      "width" : 130,
      "height" : 79
    },
    "textPosition" : {
      "x" : 421,
      "y" : 1014
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "fgColor" : {
      "r" : 0,
      "g" : 0,
      "b" : 0
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 547,
          "y" : 1012
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 547,
          "y" : 1012
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 52907,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 524,
          "y" : 1094
        },
        "to" : {
          "x" : 548,
          "y" : 1113
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 532,
          "y" : 1095
        },
        "b" : {
          "x" : 524,
          "y" : 1094
        },
        "c" : {
          "x" : 527,
          "y" : 1101
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 527,
          "y" : 1101
        }
      }
    }, {
      "edgeId" : 52911,
      "type" : "INPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 52910,
    "reactomeId" : 29370,
    "displayName" : "ADP",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 496,
      "y" : 1149
    },
    "minX" : 476,
    "maxX" : 548,
    "minY" : 1113,
    "maxY" : 1165,
    "prop" : {
      "x" : 476,
      "y" : 1134,
      "width" : 41,
      "height" : 31
    },
    "textPosition" : {
      "x" : 480,
      "y" : 1139
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "fgColor" : {
      "r" : 0,
      "g" : 0,
      "b" : 0
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 512,
          "y" : 1139
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 512,
          "y" : 1139
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 52907,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 520,
          "y" : 1134
        },
        "to" : {
          "x" : 548,
          "y" : 1113
        }
      } ],
      "stoichiometry" : {
        "value" : 4,
        "shape" : {
          "a" : {
            "x" : 528,
            "y" : 1117
          },
          "b" : {
            "x" : 540,
            "y" : 1129
          },
          "type" : "BOX",
          "empty" : true,
          "centre" : {
            "x" : 534,
            "y" : 1123
          }
        }
      },
      "endShape" : {
        "a" : {
          "x" : 523,
          "y" : 1127
        },
        "b" : {
          "x" : 520,
          "y" : 1134
        },
        "c" : {
          "x" : 528,
          "y" : 1133
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 528,
          "y" : 1133
        }
      }
    } ]
  }, {
    "id" : 52912,
    "reactomeId" : 10018688,
    "displayName" : "K63pUb-TRAF6:TAB1:TAB2,TAB3:free pUb:p-T-TAK1",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 304,
      "y" : 1052
    },
    "minX" : 241,
    "maxX" : 373,
    "minY" : 1006,
    "maxY" : 1078,
    "prop" : {
      "x" : 241,
      "y" : 1027,
      "width" : 126,
      "height" : 51
    },
    "textPosition" : {
      "x" : 244,
      "y" : 1029
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 367,
          "y" : 1027
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 367,
          "y" : 1027
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 52911,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 327,
          "y" : 1024
        },
        "to" : {
          "x" : 346,
          "y" : 1006
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 329,
          "y" : 1016
        },
        "b" : {
          "x" : 327,
          "y" : 1024
        },
        "c" : {
          "x" : 335,
          "y" : 1022
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 335,
          "y" : 1022
        }
      }
    } ]
  }, {
    "id" : 52914,
    "reactomeId" : 10043628,
    "displayName" : "Traf3",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 714,
      "y" : 82
    },
    "minX" : 691,
    "maxX" : 778,
    "minY" : 65,
    "maxY" : 98,
    "prop" : {
      "x" : 691,
      "y" : 71,
      "width" : 47,
      "height" : 23
    },
    "textPosition" : {
      "x" : 694,
      "y" : 72
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 738,
          "y" : 71
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 738,
          "y" : 71
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 52913,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 741,
          "y" : 87
        },
        "to" : {
          "x" : 778,
          "y" : 97
        }
      } ],
      "stoichiometry" : {
        "value" : 2,
        "shape" : {
          "a" : {
            "x" : 753,
            "y" : 86
          },
          "b" : {
            "x" : 765,
            "y" : 98
          },
          "type" : "BOX",
          "empty" : true,
          "centre" : {
            "x" : 759,
            "y" : 92
          }
        }
      }
    } ]
  }, {
    "id" : 52915,
    "reactomeId" : 10043630,
    "displayName" : "TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 1040,
      "y" : 183
    },
    "minX" : 983,
    "maxX" : 1125,
    "minY" : 134,
    "maxY" : 209,
    "prop" : {
      "x" : 983,
      "y" : 158,
      "width" : 114,
      "height" : 51
    },
    "textPosition" : {
      "x" : 984,
      "y" : 160
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "fgColor" : {
      "r" : 0,
      "g" : 0,
      "b" : 0
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1097,
          "y" : 158
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1097,
          "y" : 158
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 52913,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 52916,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1063,
          "y" : 155
        },
        "to" : {
          "x" : 1085,
          "y" : 134
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 52916,
      "type" : "CATALYST",
      "segments" : [ {
        "from" : {
          "x" : 1100,
          "y" : 161
        },
        "to" : {
          "x" : 1116,
          "y" : 154
        }
      }, {
        "from" : {
          "x" : 1116,
          "y" : 154
        },
        "to" : {
          "x" : 1119,
          "y" : 148
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 1121,
          "y" : 145
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1121,
          "y" : 145
        }
      }
    } ]
  }, {
    "id" : 52917,
    "reactomeId" : 9985374,
    "displayName" : "Ub",
    "schemaClass" : "DefinedSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 1068,
      "y" : 99
    },
    "minX" : 1056,
    "maxX" : 1085,
    "minY" : 88,
    "maxY" : 134,
    "prop" : {
      "x" : 1056,
      "y" : 88,
      "width" : 25,
      "height" : 23
    },
    "textPosition" : {
      "x" : 1056,
      "y" : 89
    },
    "connectors" : [ {
      "edgeId" : 52916,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1073,
          "y" : 117
        },
        "to" : {
          "x" : 1085,
          "y" : 134
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 52918,
    "reactomeId" : 9996547,
    "displayName" : "K63polyUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 1190,
      "y" : 186
    },
    "minX" : 1125,
    "maxX" : 1261,
    "minY" : 137,
    "maxY" : 212,
    "prop" : {
      "x" : 1125,
      "y" : 161,
      "width" : 130,
      "height" : 51
    },
    "textPosition" : {
      "x" : 1127,
      "y" : 163
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "fgColor" : {
      "r" : 0,
      "g" : 0,
      "b" : 0
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1255,
          "y" : 161
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1255,
          "y" : 161
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 52931,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1205,
          "y" : 158
        },
        "to" : {
          "x" : 1220,
          "y" : 137
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 52916,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 52920,
    "reactomeId" : 9997058,
    "displayName" : "SARM-1",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 73,
      "y" : 150
    },
    "minX" : 45,
    "maxX" : 107,
    "minY" : 133,
    "maxY" : 188,
    "prop" : {
      "x" : 45,
      "y" : 139,
      "width" : 56,
      "height" : 23
    },
    "textPosition" : {
      "x" : 46,
      "y" : 140
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 101,
          "y" : 139
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 101,
          "y" : 139
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 52919,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 81,
          "y" : 165
        },
        "to" : {
          "x" : 100,
          "y" : 188
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 52922,
    "reactomeId" : 9988617,
    "displayName" : "Fadd",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 91,
      "y" : 585
    },
    "minX" : 71,
    "maxX" : 150,
    "minY" : 568,
    "maxY" : 597,
    "prop" : {
      "x" : 71,
      "y" : 574,
      "width" : 41,
      "height" : 23
    },
    "textPosition" : {
      "x" : 72,
      "y" : 575
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 112,
          "y" : 574
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 112,
          "y" : 574
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 52921,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 115,
          "y" : 584
        },
        "to" : {
          "x" : 150,
          "y" : 584
        }
      } ],
      "stoichiometry" : {
        "value" : 2,
        "shape" : {
          "a" : {
            "x" : 126,
            "y" : 578
          },
          "b" : {
            "x" : 138,
            "y" : 590
          },
          "type" : "BOX",
          "empty" : true,
          "centre" : {
            "x" : 132,
            "y" : 584
          }
        }
      }
    } ]
  }, {
    "id" : 52923,
    "reactomeId" : 9988623,
    "displayName" : "Casp8",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 100,
      "y" : 627
    },
    "minX" : 54,
    "maxX" : 153,
    "minY" : 584,
    "maxY" : 639,
    "prop" : {
      "x" : 54,
      "y" : 616,
      "width" : 93,
      "height" : 23
    },
    "textPosition" : {
      "x" : 77,
      "y" : 617
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 147,
          "y" : 616
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 147,
          "y" : 616
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 52921,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 113,
          "y" : 613
        },
        "to" : {
          "x" : 150,
          "y" : 584
        }
      } ],
      "stoichiometry" : {
        "value" : 2,
        "shape" : {
          "a" : {
            "x" : 125,
            "y" : 592
          },
          "b" : {
            "x" : 137,
            "y" : 604
          },
          "type" : "BOX",
          "empty" : true,
          "centre" : {
            "x" : 131,
            "y" : 598
          }
        }
      }
    } ]
  }, {
    "id" : 52924,
    "reactomeId" : 10045840,
    "displayName" : "activated TLR4:TRIF:RIP1:FADD:pro-caspase-8",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 225,
      "y" : 654
    },
    "minX" : 148,
    "maxX" : 295,
    "minY" : 623,
    "maxY" : 696,
    "prop" : {
      "x" : 161,
      "y" : 629,
      "width" : 128,
      "height" : 51
    },
    "textPosition" : {
      "x" : 172,
      "y" : 631
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "fgColor" : {
      "r" : 0,
      "g" : 0,
      "b" : 0
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 289,
          "y" : 629
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 289,
          "y" : 629
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 52921,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 52925,
      "type" : "INPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 52925,
      "type" : "CATALYST",
      "segments" : [ {
        "from" : {
          "x" : 158,
          "y" : 677
        },
        "to" : {
          "x" : 148,
          "y" : 682
        }
      }, {
        "from" : {
          "x" : 148,
          "y" : 682
        },
        "to" : {
          "x" : 156,
          "y" : 689
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 159,
          "y" : 692
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 159,
          "y" : 692
        }
      }
    } ]
  }, {
    "id" : 52926,
    "reactomeId" : 9993328,
    "displayName" : "active caspase-8",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 101,
      "y" : 748
    },
    "minX" : 47,
    "maxX" : 166,
    "minY" : 720,
    "maxY" : 760,
    "prop" : {
      "x" : 47,
      "y" : 737,
      "width" : 108,
      "height" : 23
    },
    "textPosition" : {
      "x" : 48,
      "y" : 725
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 155,
          "y" : 737
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 155,
          "y" : 737
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 52925,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 127,
          "y" : 734
        },
        "to" : {
          "x" : 166,
          "y" : 720
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 132,
          "y" : 728
        },
        "b" : {
          "x" : 127,
          "y" : 734
        },
        "c" : {
          "x" : 135,
          "y" : 735
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 135,
          "y" : 735
        }
      }
    } ]
  }, {
    "id" : 52927,
    "reactomeId" : 10045845,
    "displayName" : "activated TLR4:TRIF:RIP1:FADD",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 234,
      "y" : 752
    },
    "minX" : 166,
    "maxX" : 304,
    "minY" : 720,
    "maxY" : 771,
    "prop" : {
      "x" : 170,
      "y" : 734,
      "width" : 128,
      "height" : 37
    },
    "textPosition" : {
      "x" : 182,
      "y" : 736
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "fgColor" : {
      "r" : 0,
      "g" : 0,
      "b" : 0
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 298,
          "y" : 734
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 298,
          "y" : 734
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 52925,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 194,
          "y" : 731
        },
        "to" : {
          "x" : 166,
          "y" : 720
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 186,
          "y" : 732
        },
        "b" : {
          "x" : 194,
          "y" : 731
        },
        "c" : {
          "x" : 189,
          "y" : 725
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 189,
          "y" : 725
        }
      }
    } ]
  }, {
    "id" : 52929,
    "reactomeId" : 10045854,
    "displayName" : "TRIF:activated TLR4",
    "schemaClass" : "CandidateSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 197,
      "y" : 292
    },
    "minX" : 135,
    "maxX" : 259,
    "minY" : 281,
    "maxY" : 357,
    "prop" : {
      "x" : 135,
      "y" : 281,
      "width" : 124,
      "height" : 23
    },
    "textPosition" : {
      "x" : 147,
      "y" : 275
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "fgColor" : {
      "r" : 0,
      "g" : 0,
      "b" : 0
    },
    "connectors" : [ {
      "edgeId" : 52928,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 192,
          "y" : 310
        },
        "to" : {
          "x" : 174,
          "y" : 357
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 52930,
    "reactomeId" : 10045860,
    "displayName" : "RIP3:TICAM1:activated TLR4",
    "schemaClass" : "CandidateSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 190,
      "y" : 474
    },
    "minX" : 143,
    "maxX" : 238,
    "minY" : 456,
    "maxY" : 493,
    "prop" : {
      "x" : 143,
      "y" : 456,
      "width" : 95,
      "height" : 37
    },
    "textPosition" : {
      "x" : 147,
      "y" : 450
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "connectors" : [ {
      "edgeId" : 52928,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 52932,
    "reactomeId" : 10054443,
    "displayName" : "TANK",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 1201,
      "y" : 103
    },
    "minX" : 1180,
    "maxX" : 1228,
    "minY" : 86,
    "maxY" : 137,
    "prop" : {
      "x" : 1180,
      "y" : 92,
      "width" : 42,
      "height" : 23
    },
    "textPosition" : {
      "x" : 1181,
      "y" : 93
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1222,
          "y" : 92
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1222,
          "y" : 92
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 52931,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1207,
          "y" : 118
        },
        "to" : {
          "x" : 1220,
          "y" : 137
        }
      } ],
      "stoichiometry" : {
        "value" : 2,
        "shape" : {
          "a" : {
            "x" : 1207,
            "y" : 121
          },
          "b" : {
            "x" : 1219,
            "y" : 133
          },
          "type" : "BOX",
          "empty" : true,
          "centre" : {
            "x" : 1213,
            "y" : 127
          }
        }
      }
    } ]
  }, {
    "id" : 52933,
    "reactomeId" : 10054445,
    "displayName" : "TANK:K63-poly-Ub-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 1334,
      "y" : 182
    },
    "minX" : 1269,
    "maxX" : 1406,
    "minY" : 138,
    "maxY" : 215,
    "prop" : {
      "x" : 1269,
      "y" : 150,
      "width" : 131,
      "height" : 65
    },
    "textPosition" : {
      "x" : 1274,
      "y" : 152
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1400,
          "y" : 150
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1400,
          "y" : 150
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 52931,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 52934,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1379,
          "y" : 147
        },
        "to" : {
          "x" : 1396,
          "y" : 138
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 52935,
    "reactomeId" : 9985374,
    "displayName" : "Ub",
    "schemaClass" : "DefinedSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 1366,
      "y" : 119
    },
    "minX" : 1354,
    "maxX" : 1396,
    "minY" : 108,
    "maxY" : 138,
    "prop" : {
      "x" : 1354,
      "y" : 108,
      "width" : 25,
      "height" : 23
    },
    "textPosition" : {
      "x" : 1354,
      "y" : 109
    },
    "connectors" : [ {
      "edgeId" : 52934,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1385,
          "y" : 126
        },
        "to" : {
          "x" : 1396,
          "y" : 138
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 52936,
    "reactomeId" : 9996554,
    "displayName" : "K63pUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 1481,
      "y" : 188
    },
    "minX" : 1416,
    "maxX" : 1633,
    "minY" : 150,
    "maxY" : 295,
    "prop" : {
      "x" : 1416,
      "y" : 156,
      "width" : 130,
      "height" : 65
    },
    "textPosition" : {
      "x" : 1418,
      "y" : 158
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1546,
          "y" : 156
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1546,
          "y" : 156
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 52934,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 52940,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1518,
          "y" : 224
        },
        "to" : {
          "x" : 1556,
          "y" : 253
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 52943,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1527,
          "y" : 224
        },
        "to" : {
          "x" : 1633,
          "y" : 295
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 52938,
    "reactomeId" : 9985374,
    "displayName" : "Ub",
    "schemaClass" : "DefinedSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 1550,
      "y" : 924
    },
    "minX" : 1409,
    "maxX" : 1563,
    "minY" : 913,
    "maxY" : 966,
    "prop" : {
      "x" : 1538,
      "y" : 913,
      "width" : 25,
      "height" : 23
    },
    "textPosition" : {
      "x" : 1538,
      "y" : 914
    },
    "connectors" : [ {
      "edgeId" : 52937,
      "type" : "INPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 52957,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1532,
          "y" : 927
        },
        "to" : {
          "x" : 1409,
          "y" : 964
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 52959,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1532,
          "y" : 928
        },
        "to" : {
          "x" : 1443,
          "y" : 966
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 52939,
    "reactomeId" : 10018718,
    "displayName" : "K63-linked polyUb TRAF6 complexes",
    "schemaClass" : "DefinedSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 1453,
      "y" : 1047
    },
    "minX" : 1392,
    "maxX" : 1542,
    "minY" : 974,
    "maxY" : 1066,
    "prop" : {
      "x" : 1392,
      "y" : 1029,
      "width" : 123,
      "height" : 37
    },
    "textPosition" : {
      "x" : 1392,
      "y" : 1030
    },
    "connectors" : [ {
      "edgeId" : 52937,
      "type" : "CATALYST",
      "segments" : [ {
        "from" : {
          "x" : 1472,
          "y" : 1023
        },
        "to" : {
          "x" : 1526,
          "y" : 978
        }
      }, {
        "from" : {
          "x" : 1526,
          "y" : 978
        },
        "to" : {
          "x" : 1534,
          "y" : 978
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 1538,
          "y" : 978
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1538,
          "y" : 978
        }
      }
    } ]
  }, {
    "id" : 52941,
    "reactomeId" : 10022897,
    "displayName" : "IKBKE",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 1581,
      "y" : 204
    },
    "minX" : 1556,
    "maxX" : 1608,
    "minY" : 187,
    "maxY" : 253,
    "prop" : {
      "x" : 1560,
      "y" : 193,
      "width" : 42,
      "height" : 23
    },
    "textPosition" : {
      "x" : 1560,
      "y" : 194
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1602,
          "y" : 193
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1602,
          "y" : 193
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 52940,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1575,
          "y" : 219
        },
        "to" : {
          "x" : 1556,
          "y" : 253
        }
      } ],
      "stoichiometry" : {
        "value" : 2,
        "shape" : {
          "a" : {
            "x" : 1559,
            "y" : 230
          },
          "b" : {
            "x" : 1571,
            "y" : 242
          },
          "type" : "BOX",
          "empty" : true,
          "centre" : {
            "x" : 1565,
            "y" : 236
          }
        }
      }
    } ]
  }, {
    "id" : 52942,
    "reactomeId" : 10093612,
    "displayName" : "IKBKE:K63polyUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 1459,
      "y" : 291
    },
    "minX" : 1350,
    "maxX" : 1539,
    "minY" : 246,
    "maxY" : 964,
    "prop" : {
      "x" : 1401,
      "y" : 252,
      "width" : 117,
      "height" : 79
    },
    "textPosition" : {
      "x" : 1402,
      "y" : 254
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1518,
          "y" : 252
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1518,
          "y" : 252
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 52940,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 52946,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1521,
          "y" : 317
        },
        "to" : {
          "x" : 1539,
          "y" : 327
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 52957,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1398,
          "y" : 289
        },
        "to" : {
          "x" : 1350,
          "y" : 288
        }
      }, {
        "from" : {
          "x" : 1350,
          "y" : 288
        },
        "to" : {
          "x" : 1356,
          "y" : 918
        }
      }, {
        "from" : {
          "x" : 1356,
          "y" : 918
        },
        "to" : {
          "x" : 1409,
          "y" : 964
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 52944,
    "reactomeId" : 1810477,
    "displayName" : "Tbk1",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 1640,
      "y" : 219
    },
    "minX" : 1620,
    "maxX" : 1666,
    "minY" : 202,
    "maxY" : 295,
    "prop" : {
      "x" : 1620,
      "y" : 208,
      "width" : 40,
      "height" : 23
    },
    "textPosition" : {
      "x" : 1621,
      "y" : 209
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1660,
          "y" : 208
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1660,
          "y" : 208
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 52943,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1638,
          "y" : 234
        },
        "to" : {
          "x" : 1633,
          "y" : 295
        }
      } ],
      "stoichiometry" : {
        "value" : 2,
        "shape" : {
          "a" : {
            "x" : 1629,
            "y" : 258
          },
          "b" : {
            "x" : 1641,
            "y" : 270
          },
          "type" : "BOX",
          "empty" : true,
          "centre" : {
            "x" : 1635,
            "y" : 264
          }
        }
      }
    } ]
  }, {
    "id" : 52945,
    "reactomeId" : 10093591,
    "displayName" : "TBK1:K63polyUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 1469,
      "y" : 492
    },
    "minX" : 1370,
    "maxX" : 1646,
    "minY" : 447,
    "maxY" : 966,
    "prop" : {
      "x" : 1412,
      "y" : 453,
      "width" : 115,
      "height" : 79
    },
    "textPosition" : {
      "x" : 1414,
      "y" : 455
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1527,
          "y" : 453
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1527,
          "y" : 453
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 52943,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 52950,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1530,
          "y" : 514
        },
        "to" : {
          "x" : 1646,
          "y" : 562
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 52955,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1508,
          "y" : 535
        },
        "to" : {
          "x" : 1530,
          "y" : 553
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 52959,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1409,
          "y" : 526
        },
        "to" : {
          "x" : 1371,
          "y" : 550
        }
      }, {
        "from" : {
          "x" : 1371,
          "y" : 550
        },
        "to" : {
          "x" : 1370,
          "y" : 914
        }
      }, {
        "from" : {
          "x" : 1370,
          "y" : 914
        },
        "to" : {
          "x" : 1443,
          "y" : 966
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 52947,
    "reactomeId" : 113592,
    "displayName" : "ATP",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 1586,
      "y" : 308
    },
    "minX" : 1539,
    "maxX" : 1607,
    "minY" : 292,
    "maxY" : 327,
    "prop" : {
      "x" : 1566,
      "y" : 293,
      "width" : 40,
      "height" : 31
    },
    "textPosition" : {
      "x" : 1570,
      "y" : 298
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1601,
          "y" : 298
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1601,
          "y" : 298
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 52946,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1563,
          "y" : 316
        },
        "to" : {
          "x" : 1539,
          "y" : 327
        }
      } ],
      "stoichiometry" : {
        "value" : 2,
        "shape" : {
          "a" : {
            "x" : 1545,
            "y" : 315
          },
          "b" : {
            "x" : 1557,
            "y" : 327
          },
          "type" : "BOX",
          "empty" : true,
          "centre" : {
            "x" : 1551,
            "y" : 321
          }
        }
      }
    } ]
  }, {
    "id" : 52948,
    "reactomeId" : 29370,
    "displayName" : "ADP",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 1590,
      "y" : 375
    },
    "minX" : 1541,
    "maxX" : 1612,
    "minY" : 359,
    "maxY" : 391,
    "prop" : {
      "x" : 1570,
      "y" : 360,
      "width" : 41,
      "height" : 31
    },
    "textPosition" : {
      "x" : 1574,
      "y" : 365
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1606,
          "y" : 365
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1606,
          "y" : 365
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 52946,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 1567,
          "y" : 369
        },
        "to" : {
          "x" : 1541,
          "y" : 361
        }
      } ],
      "stoichiometry" : {
        "value" : 2,
        "shape" : {
          "a" : {
            "x" : 1548,
            "y" : 359
          },
          "b" : {
            "x" : 1560,
            "y" : 371
          },
          "type" : "BOX",
          "empty" : true,
          "centre" : {
            "x" : 1554,
            "y" : 365
          }
        }
      },
      "endShape" : {
        "a" : {
          "x" : 1559,
          "y" : 371
        },
        "b" : {
          "x" : 1567,
          "y" : 369
        },
        "c" : {
          "x" : 1562,
          "y" : 363
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 1562,
          "y" : 363
        }
      }
    } ]
  }, {
    "id" : 52949,
    "reactomeId" : 9996558,
    "displayName" : "p-S172-IKBKE:K63polyUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 1453,
      "y" : 396
    },
    "minX" : 1388,
    "maxX" : 1541,
    "minY" : 351,
    "maxY" : 436,
    "prop" : {
      "x" : 1388,
      "y" : 357,
      "width" : 130,
      "height" : 79
    },
    "textPosition" : {
      "x" : 1390,
      "y" : 359
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1518,
          "y" : 357
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1518,
          "y" : 357
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 52946,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 1521,
          "y" : 370
        },
        "to" : {
          "x" : 1541,
          "y" : 361
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 1526,
          "y" : 364
        },
        "b" : {
          "x" : 1521,
          "y" : 370
        },
        "c" : {
          "x" : 1529,
          "y" : 371
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 1529,
          "y" : 371
        }
      }
    } ]
  }, {
    "id" : 52951,
    "reactomeId" : 113592,
    "displayName" : "ATP",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 1643,
      "y" : 516
    },
    "minX" : 1623,
    "maxX" : 1664,
    "minY" : 500,
    "maxY" : 562,
    "prop" : {
      "x" : 1623,
      "y" : 501,
      "width" : 40,
      "height" : 31
    },
    "textPosition" : {
      "x" : 1627,
      "y" : 506
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1658,
          "y" : 506
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1658,
          "y" : 506
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 52950,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1644,
          "y" : 535
        },
        "to" : {
          "x" : 1646,
          "y" : 562
        }
      } ],
      "stoichiometry" : {
        "value" : 2,
        "shape" : {
          "a" : {
            "x" : 1639,
            "y" : 542
          },
          "b" : {
            "x" : 1651,
            "y" : 554
          },
          "type" : "BOX",
          "empty" : true,
          "centre" : {
            "x" : 1645,
            "y" : 548
          }
        }
      }
    } ]
  }, {
    "id" : 52952,
    "reactomeId" : 29370,
    "displayName" : "ADP",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 1650,
      "y" : 686
    },
    "minX" : 1630,
    "maxX" : 1672,
    "minY" : 633,
    "maxY" : 702,
    "prop" : {
      "x" : 1630,
      "y" : 671,
      "width" : 41,
      "height" : 31
    },
    "textPosition" : {
      "x" : 1634,
      "y" : 676
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1666,
          "y" : 676
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1666,
          "y" : 676
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 52950,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 1649,
          "y" : 668
        },
        "to" : {
          "x" : 1649,
          "y" : 633
        }
      } ],
      "stoichiometry" : {
        "value" : 2,
        "shape" : {
          "a" : {
            "x" : 1643,
            "y" : 644
          },
          "b" : {
            "x" : 1655,
            "y" : 656
          },
          "type" : "BOX",
          "empty" : true,
          "centre" : {
            "x" : 1649,
            "y" : 650
          }
        }
      },
      "endShape" : {
        "a" : {
          "x" : 1645,
          "y" : 661
        },
        "b" : {
          "x" : 1649,
          "y" : 668
        },
        "c" : {
          "x" : 1653,
          "y" : 661
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 1653,
          "y" : 661
        }
      }
    } ]
  }, {
    "id" : 52953,
    "reactomeId" : 9996556,
    "displayName" : "p-S172-TBK1:K63polyUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 1462,
      "y" : 699
    },
    "minX" : 1397,
    "maxX" : 1649,
    "minY" : 633,
    "maxY" : 739,
    "prop" : {
      "x" : 1397,
      "y" : 660,
      "width" : 130,
      "height" : 79
    },
    "textPosition" : {
      "x" : 1399,
      "y" : 662
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1527,
          "y" : 660
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1527,
          "y" : 660
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 52950,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 1530,
          "y" : 676
        },
        "to" : {
          "x" : 1649,
          "y" : 633
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 1535,
          "y" : 670
        },
        "b" : {
          "x" : 1530,
          "y" : 676
        },
        "c" : {
          "x" : 1538,
          "y" : 677
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 1538,
          "y" : 677
        }
      }
    } ]
  }, {
    "id" : 52954,
    "reactomeId" : 10093603,
    "displayName" : "OPTN:TBK1:K63polyUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 1447,
      "y" : 607
    },
    "minX" : 1382,
    "maxX" : 1638,
    "minY" : 562,
    "maxY" : 647,
    "prop" : {
      "x" : 1382,
      "y" : 568,
      "width" : 130,
      "height" : 79
    },
    "textPosition" : {
      "x" : 1384,
      "y" : 570
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1512,
          "y" : 568
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1512,
          "y" : 568
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 52950,
      "type" : "ACTIVATOR",
      "segments" : [ {
        "from" : {
          "x" : 1515,
          "y" : 606
        },
        "to" : {
          "x" : 1638,
          "y" : 605
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 1631,
          "y" : 609
        },
        "b" : {
          "x" : 1638,
          "y" : 605
        },
        "c" : {
          "x" : 1631,
          "y" : 601
        },
        "type" : "ARROW",
        "empty" : true,
        "centre" : {
          "x" : 1631,
          "y" : 601
        }
      }
    }, {
      "edgeId" : 52955,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 52956,
    "reactomeId" : 10054127,
    "displayName" : "OPTN",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 1568,
      "y" : 554
    },
    "minX" : 1530,
    "maxX" : 1595,
    "minY" : 537,
    "maxY" : 566,
    "prop" : {
      "x" : 1547,
      "y" : 543,
      "width" : 42,
      "height" : 23
    },
    "textPosition" : {
      "x" : 1547,
      "y" : 544
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1589,
          "y" : 543
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1589,
          "y" : 543
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 52955,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1544,
          "y" : 553
        },
        "to" : {
          "x" : 1530,
          "y" : 553
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 52958,
    "reactomeId" : 10093624,
    "displayName" : "K63polyUb-IKBKE:K63polyUb-TANK:K63polyUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 1151,
      "y" : 1030
    },
    "minX" : 1086,
    "maxX" : 1222,
    "minY" : 985,
    "maxY" : 1070,
    "prop" : {
      "x" : 1086,
      "y" : 991,
      "width" : 130,
      "height" : 79
    },
    "textPosition" : {
      "x" : 1088,
      "y" : 993
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1216,
          "y" : 991
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1216,
          "y" : 991
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 52957,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 52960,
    "reactomeId" : 10093599,
    "displayName" : "K63polyUb-TBK1:K63polyUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 1311,
      "y" : 1042
    },
    "minX" : 1246,
    "maxX" : 1382,
    "minY" : 997,
    "maxY" : 1082,
    "prop" : {
      "x" : 1246,
      "y" : 1003,
      "width" : 130,
      "height" : 79
    },
    "textPosition" : {
      "x" : 1248,
      "y" : 1005
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1376,
          "y" : 1003
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1376,
          "y" : 1003
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 52959,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 52963,
    "reactomeId" : 10099317,
    "displayName" : "MAP kinase activation",
    "schemaClass" : "Pathway",
    "renderableClass" : "ProcessNode",
    "position" : {
      "x" : 395,
      "y" : 1144
    },
    "minX" : 352,
    "maxX" : 439,
    "minY" : 1122,
    "maxY" : 1167,
    "prop" : {
      "x" : 352,
      "y" : 1122,
      "width" : 87,
      "height" : 45
    },
    "textPosition" : {
      "x" : 350,
      "y" : 1123
    },
    "connectors" : [ ]
  }, {
    "id" : 52964,
    "reactomeId" : 10099345,
    "displayName" : "TAK1-dependent IKK and NF-kappa-B activation",
    "schemaClass" : "Pathway",
    "renderableClass" : "ProcessNode",
    "position" : {
      "x" : 232,
      "y" : 1154
    },
    "minX" : 165,
    "maxX" : 299,
    "minY" : 1125,
    "maxY" : 1184,
    "prop" : {
      "x" : 165,
      "y" : 1125,
      "width" : 134,
      "height" : 59
    },
    "textPosition" : {
      "x" : 168,
      "y" : 1126
    },
    "connectors" : [ ]
  }, {
    "id" : 52966,
    "reactomeId" : 10098665,
    "displayName" : "Apoptosis",
    "schemaClass" : "Pathway",
    "renderableClass" : "EncapsulatedNode",
    "position" : {
      "x" : 100,
      "y" : 799
    },
    "minX" : 54,
    "maxX" : 147,
    "minY" : 781,
    "maxY" : 818,
    "prop" : {
      "x" : 54,
      "y" : 781,
      "width" : 93,
      "height" : 37
    },
    "textPosition" : {
      "x" : 61,
      "y" : 785
    },
    "connectors" : [ ]
  }, {
    "id" : 52967,
    "reactomeId" : 10099017,
    "displayName" : "Regulated Necrosis",
    "schemaClass" : "Pathway",
    "renderableClass" : "EncapsulatedNode",
    "position" : {
      "x" : 123,
      "y" : 401
    },
    "minX" : 79,
    "maxX" : 167,
    "minY" : 379,
    "maxY" : 424,
    "prop" : {
      "x" : 79,
      "y" : 379,
      "width" : 88,
      "height" : 45
    },
    "textPosition" : {
      "x" : 81,
      "y" : 380
    },
    "connectors" : [ ]
  } ],
  "edges" : [ {
    "id" : 52928,
    "reactomeId" : 10045862,
    "displayName" : "RIP3 binds TRIF to mediate necroptosis",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 175,
      "y" : 371
    },
    "minX" : 169,
    "maxX" : 187,
    "minY" : 357,
    "maxY" : 450,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 174,
        "y" : 357
      },
      "to" : {
        "x" : 175,
        "y" : 371
      }
    }, {
      "from" : {
        "x" : 175,
        "y" : 371
      },
      "to" : {
        "x" : 187,
        "y" : 450
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 182,
        "y" : 444
      },
      "b" : {
        "x" : 187,
        "y" : 450
      },
      "c" : {
        "x" : 190,
        "y" : 443
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 190,
        "y" : 443
      }
    },
    "reactionShape" : {
      "a" : {
        "x" : 169,
        "y" : 365
      },
      "b" : {
        "x" : 181,
        "y" : 377
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 175,
        "y" : 371
      }
    },
    "inputs" : [ {
      "id" : 52880,
      "points" : [ {
        "x" : 147,
        "y" : 341
      } ],
      "stoichiometry" : 4
    }, {
      "id" : 52929,
      "points" : [ {
        "x" : 192,
        "y" : 310
      } ]
    } ],
    "outputs" : [ {
      "id" : 52930
    } ]
  }, {
    "id" : 52931,
    "reactomeId" : 10054447,
    "displayName" : "TANK binds K63-poly-Ub-TRAF3:TICAM1:activated TLR4",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 1243,
      "y" : 138
    },
    "minX" : 1220,
    "maxX" : 1266,
    "minY" : 132,
    "maxY" : 150,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 1220,
        "y" : 137
      },
      "to" : {
        "x" : 1243,
        "y" : 138
      }
    }, {
      "from" : {
        "x" : 1243,
        "y" : 138
      },
      "to" : {
        "x" : 1266,
        "y" : 150
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 1258,
        "y" : 150
      },
      "b" : {
        "x" : 1266,
        "y" : 150
      },
      "c" : {
        "x" : 1262,
        "y" : 143
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 1262,
        "y" : 143
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 1243,
        "y" : 138
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 1243,
        "y" : 138
      }
    },
    "inputs" : [ {
      "id" : 52932,
      "points" : [ {
        "x" : 1207,
        "y" : 118
      } ],
      "stoichiometry" : 2
    }, {
      "id" : 52918,
      "points" : [ {
        "x" : 1205,
        "y" : 158
      } ]
    } ],
    "outputs" : [ {
      "id" : 52933
    } ]
  }, {
    "id" : 52868,
    "reactomeId" : 9996511,
    "displayName" : "TRAM:TLR4:LY96:LPS:CD14 recruits TRIF (TICAM1)",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 596,
      "y" : 145
    },
    "minX" : 556,
    "maxX" : 637,
    "minY" : 139,
    "maxY" : 162,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 556,
        "y" : 144
      },
      "to" : {
        "x" : 596,
        "y" : 145
      }
    }, {
      "from" : {
        "x" : 596,
        "y" : 145
      },
      "to" : {
        "x" : 637,
        "y" : 162
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 629,
        "y" : 163
      },
      "b" : {
        "x" : 637,
        "y" : 162
      },
      "c" : {
        "x" : 632,
        "y" : 156
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 632,
        "y" : 156
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 596,
        "y" : 145
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 596,
        "y" : 145
      }
    },
    "inputs" : [ {
      "id" : 52869,
      "points" : [ {
        "x" : 525,
        "y" : 154
      } ]
    }, {
      "id" : 52870,
      "points" : [ {
        "x" : 498,
        "y" : 132
      } ],
      "stoichiometry" : 2
    } ],
    "outputs" : [ {
      "id" : 52871
    } ]
  }, {
    "id" : 52934,
    "reactomeId" : 10054449,
    "displayName" : "TANK is ubiquitinated within TANK:K63polyUb-TRAF3:TRIF:activated TLR4",
    "schemaClass" : "BlackBoxEvent",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 1416,
      "y" : 138
    },
    "minX" : 1396,
    "maxX" : 1438,
    "minY" : 132,
    "maxY" : 153,
    "reactionType" : "omitted",
    "segments" : [ {
      "from" : {
        "x" : 1396,
        "y" : 138
      },
      "to" : {
        "x" : 1416,
        "y" : 138
      }
    }, {
      "from" : {
        "x" : 1416,
        "y" : 138
      },
      "to" : {
        "x" : 1438,
        "y" : 153
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 1430,
        "y" : 152
      },
      "b" : {
        "x" : 1438,
        "y" : 153
      },
      "c" : {
        "x" : 1435,
        "y" : 146
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 1435,
        "y" : 146
      }
    },
    "reactionShape" : {
      "a" : {
        "x" : 1410,
        "y" : 132
      },
      "b" : {
        "x" : 1422,
        "y" : 144
      },
      "s" : "\\\\",
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 1416,
        "y" : 138
      }
    },
    "inputs" : [ {
      "id" : 52933,
      "points" : [ {
        "x" : 1379,
        "y" : 147
      } ]
    }, {
      "id" : 52935,
      "points" : [ {
        "x" : 1385,
        "y" : 126
      } ]
    } ],
    "outputs" : [ {
      "id" : 52936
    } ]
  }, {
    "id" : 52872,
    "reactomeId" : 9996591,
    "displayName" : "IRF3/IRF7 recruitment to p-TBK1/p-IKK epsilon bound to the activated TLR4",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 1543,
      "y" : 842
    },
    "minX" : 1524,
    "maxX" : 1549,
    "minY" : 825,
    "maxY" : 851,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 1541,
        "y" : 825
      },
      "to" : {
        "x" : 1543,
        "y" : 842
      }
    }, {
      "from" : {
        "x" : 1543,
        "y" : 842
      },
      "to" : {
        "x" : 1524,
        "y" : 851
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 1529,
        "y" : 844
      },
      "b" : {
        "x" : 1524,
        "y" : 851
      },
      "c" : {
        "x" : 1532,
        "y" : 852
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 1532,
        "y" : 852
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 1543,
        "y" : 842
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 1543,
        "y" : 842
      }
    },
    "inputs" : [ {
      "id" : 52873,
      "points" : [ {
        "x" : 1530,
        "y" : 819
      } ]
    }, {
      "id" : 52874,
      "points" : [ {
        "x" : 1566,
        "y" : 802
      } ],
      "stoichiometry" : 2
    } ],
    "outputs" : [ {
      "id" : 52875
    } ],
    "inhibitors" : [ {
      "id" : 52876,
      "points" : [ {
        "x" : 1558,
        "y" : 840
      } ]
    } ]
  }, {
    "id" : 52937,
    "reactomeId" : 10018723,
    "displayName" : "Activated TRAF6 synthesizes unanchored polyubiquitin chains upon TLR stimulation",
    "schemaClass" : "Polymerisation",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 1550,
      "y" : 978
    },
    "minX" : 1517,
    "maxX" : 1556,
    "minY" : 942,
    "maxY" : 1097,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 1550,
        "y" : 942
      },
      "to" : {
        "x" : 1550,
        "y" : 978
      }
    }, {
      "from" : {
        "x" : 1550,
        "y" : 978
      },
      "to" : {
        "x" : 1517,
        "y" : 1097
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 1515,
        "y" : 1089
      },
      "b" : {
        "x" : 1517,
        "y" : 1097
      },
      "c" : {
        "x" : 1523,
        "y" : 1091
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 1523,
        "y" : 1091
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 1550,
        "y" : 978
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 1550,
        "y" : 978
      }
    },
    "inputs" : [ {
      "id" : 52938
    } ],
    "outputs" : [ {
      "id" : 52905
    } ],
    "catalysts" : [ {
      "id" : 52939,
      "points" : [ {
        "x" : 1472,
        "y" : 1023
      }, {
        "x" : 1526,
        "y" : 978
      } ]
    } ]
  }, {
    "id" : 52940,
    "reactomeId" : 10093614,
    "displayName" : "Recruitment of IKKε (IKBKE) to K63polyUb-TANK:K63polyUb-TRAF3:TRIF:activated TLR4",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 1555,
      "y" : 271
    },
    "minX" : 1521,
    "maxX" : 1561,
    "minY" : 253,
    "maxY" : 278,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 1556,
        "y" : 253
      },
      "to" : {
        "x" : 1555,
        "y" : 271
      }
    }, {
      "from" : {
        "x" : 1555,
        "y" : 271
      },
      "to" : {
        "x" : 1521,
        "y" : 278
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 1527,
        "y" : 273
      },
      "b" : {
        "x" : 1521,
        "y" : 278
      },
      "c" : {
        "x" : 1529,
        "y" : 281
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 1529,
        "y" : 281
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 1555,
        "y" : 271
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 1555,
        "y" : 271
      }
    },
    "inputs" : [ {
      "id" : 52941,
      "points" : [ {
        "x" : 1575,
        "y" : 219
      } ],
      "stoichiometry" : 2
    }, {
      "id" : 52936,
      "points" : [ {
        "x" : 1518,
        "y" : 224
      } ]
    } ],
    "outputs" : [ {
      "id" : 52942
    } ]
  }, {
    "id" : 52877,
    "reactomeId" : 9997066,
    "displayName" : "TRIF:activated TLR3/TLR4 complex recruits RIP1",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 70,
      "y" : 359
    },
    "minX" : 64,
    "maxX" : 139,
    "minY" : 337,
    "maxY" : 507,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 70,
        "y" : 337
      },
      "to" : {
        "x" : 70,
        "y" : 359
      }
    }, {
      "from" : {
        "x" : 70,
        "y" : 359
      },
      "to" : {
        "x" : 70,
        "y" : 437
      }
    }, {
      "from" : {
        "x" : 70,
        "y" : 437
      },
      "to" : {
        "x" : 139,
        "y" : 507
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 131,
        "y" : 505
      },
      "b" : {
        "x" : 139,
        "y" : 507
      },
      "c" : {
        "x" : 137,
        "y" : 499
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 137,
        "y" : 499
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 70,
        "y" : 359
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 70,
        "y" : 359
      }
    },
    "inputs" : [ {
      "id" : 52878,
      "points" : [ {
        "x" : 60,
        "y" : 293
      } ],
      "stoichiometry" : 2
    }, {
      "id" : 52871,
      "points" : [ {
        "x" : 608,
        "y" : 193
      }, {
        "x" : 121,
        "y" : 270
      } ]
    } ],
    "outputs" : [ {
      "id" : 52879
    } ],
    "inhibitors" : [ {
      "id" : 52880,
      "points" : [ {
        "x" : 98,
        "y" : 341
      } ]
    }, {
      "id" : 52881,
      "points" : [ {
        "x" : 126,
        "y" : 217
      }, {
        "x" : 27,
        "y" : 235
      }, {
        "x" : 27,
        "y" : 358
      } ]
    } ]
  }, {
    "id" : 52943,
    "reactomeId" : 10093608,
    "displayName" : "Recruitment of TBK1 to K63polyUb-TANK:K63polyUb-TRAF3:TRIF:activated TLR4",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 1633,
      "y" : 318
    },
    "minX" : 1530,
    "maxX" : 1639,
    "minY" : 295,
    "maxY" : 492,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 1633,
        "y" : 295
      },
      "to" : {
        "x" : 1633,
        "y" : 318
      }
    }, {
      "from" : {
        "x" : 1633,
        "y" : 318
      },
      "to" : {
        "x" : 1634,
        "y" : 492
      }
    }, {
      "from" : {
        "x" : 1634,
        "y" : 492
      },
      "to" : {
        "x" : 1530,
        "y" : 492
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 1537,
        "y" : 488
      },
      "b" : {
        "x" : 1530,
        "y" : 492
      },
      "c" : {
        "x" : 1537,
        "y" : 496
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 1537,
        "y" : 496
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 1633,
        "y" : 318
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 1633,
        "y" : 318
      }
    },
    "inputs" : [ {
      "id" : 52944,
      "points" : [ {
        "x" : 1638,
        "y" : 234
      } ],
      "stoichiometry" : 2
    }, {
      "id" : 52936,
      "points" : [ {
        "x" : 1527,
        "y" : 224
      } ]
    } ],
    "outputs" : [ {
      "id" : 52945
    } ]
  }, {
    "id" : 52882,
    "reactomeId" : 9997076,
    "displayName" : "Dimerization of phosphorylated IRF3/IRF7",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 1693,
      "y" : 992
    },
    "minX" : 1678,
    "maxX" : 1699,
    "minY" : 954,
    "maxY" : 1013,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 1693,
        "y" : 954
      },
      "to" : {
        "x" : 1693,
        "y" : 992
      }
    }, {
      "from" : {
        "x" : 1693,
        "y" : 992
      },
      "to" : {
        "x" : 1678,
        "y" : 1013
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 1679,
        "y" : 1005
      },
      "b" : {
        "x" : 1678,
        "y" : 1013
      },
      "c" : {
        "x" : 1685,
        "y" : 1010
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 1685,
        "y" : 1010
      }
    },
    "reactionShape" : {
      "a" : {
        "x" : 1687,
        "y" : 986
      },
      "b" : {
        "x" : 1699,
        "y" : 998
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 1693,
        "y" : 992
      }
    },
    "inputs" : [ {
      "id" : 52883,
      "stoichiometry" : 2
    } ],
    "outputs" : [ {
      "id" : 52884
    } ]
  }, {
    "id" : 52946,
    "reactomeId" : 10093645,
    "displayName" : "IKKε (IKBKE) is phosphorylated within the activated TLR4 complex",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 1540,
      "y" : 345
    },
    "minX" : 1534,
    "maxX" : 1546,
    "minY" : 327,
    "maxY" : 361,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 1539,
        "y" : 327
      },
      "to" : {
        "x" : 1540,
        "y" : 345
      }
    }, {
      "from" : {
        "x" : 1540,
        "y" : 345
      },
      "to" : {
        "x" : 1541,
        "y" : 361
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 1534,
        "y" : 339
      },
      "b" : {
        "x" : 1546,
        "y" : 351
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 1540,
        "y" : 345
      }
    },
    "inputs" : [ {
      "id" : 52942,
      "points" : [ {
        "x" : 1521,
        "y" : 317
      } ]
    }, {
      "id" : 52947,
      "points" : [ {
        "x" : 1563,
        "y" : 316
      } ],
      "stoichiometry" : 2
    } ],
    "outputs" : [ {
      "id" : 52948,
      "points" : [ {
        "x" : 1567,
        "y" : 369
      } ],
      "stoichiometry" : 2
    }, {
      "id" : 52949,
      "points" : [ {
        "x" : 1521,
        "y" : 370
      } ]
    } ]
  }, {
    "id" : 52885,
    "reactomeId" : 9999610,
    "displayName" : "Dimerized phospho-IRF3/IRF7 is transported to the nucleus",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 1668,
      "y" : 1075
    },
    "minX" : 1662,
    "maxX" : 1674,
    "minY" : 1062,
    "maxY" : 1114,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 1668,
        "y" : 1062
      },
      "to" : {
        "x" : 1668,
        "y" : 1075
      }
    }, {
      "from" : {
        "x" : 1668,
        "y" : 1075
      },
      "to" : {
        "x" : 1665,
        "y" : 1114
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 1662,
        "y" : 1107
      },
      "b" : {
        "x" : 1665,
        "y" : 1114
      },
      "c" : {
        "x" : 1670,
        "y" : 1107
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 1670,
        "y" : 1107
      }
    },
    "reactionShape" : {
      "a" : {
        "x" : 1662,
        "y" : 1069
      },
      "b" : {
        "x" : 1674,
        "y" : 1081
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 1668,
        "y" : 1075
      }
    },
    "inputs" : [ {
      "id" : 52884
    } ],
    "outputs" : [ {
      "id" : 52886
    } ]
  }, {
    "id" : 52950,
    "reactomeId" : 10093605,
    "displayName" : "TBK1 is phosphorylated within the activated TLR4 complex",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 1647,
      "y" : 605
    },
    "minX" : 1641,
    "maxX" : 1653,
    "minY" : 562,
    "maxY" : 633,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 1646,
        "y" : 562
      },
      "to" : {
        "x" : 1647,
        "y" : 605
      }
    }, {
      "from" : {
        "x" : 1647,
        "y" : 605
      },
      "to" : {
        "x" : 1649,
        "y" : 633
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 1641,
        "y" : 599
      },
      "b" : {
        "x" : 1653,
        "y" : 611
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 1647,
        "y" : 605
      }
    },
    "inputs" : [ {
      "id" : 52951,
      "points" : [ {
        "x" : 1644,
        "y" : 535
      } ],
      "stoichiometry" : 2
    }, {
      "id" : 52945,
      "points" : [ {
        "x" : 1530,
        "y" : 514
      } ]
    } ],
    "outputs" : [ {
      "id" : 52952,
      "points" : [ {
        "x" : 1649,
        "y" : 668
      } ],
      "stoichiometry" : 2
    }, {
      "id" : 52953,
      "points" : [ {
        "x" : 1530,
        "y" : 676
      } ]
    } ],
    "activators" : [ {
      "id" : 52954,
      "points" : [ {
        "x" : 1515,
        "y" : 606
      } ]
    } ]
  }, {
    "id" : 52887,
    "reactomeId" : 9996587,
    "displayName" : "Phosphorylation of IRF-3/IRF7 and their release from the activated TLR complex",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 1670,
      "y" : 856
    },
    "minX" : 1644,
    "maxX" : 1692,
    "minY" : 850,
    "maxY" : 862,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 1644,
        "y" : 856
      },
      "to" : {
        "x" : 1670,
        "y" : 856
      }
    }, {
      "from" : {
        "x" : 1670,
        "y" : 856
      },
      "to" : {
        "x" : 1692,
        "y" : 856
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 1664,
        "y" : 850
      },
      "b" : {
        "x" : 1676,
        "y" : 862
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 1670,
        "y" : 856
      }
    },
    "inputs" : [ {
      "id" : 52888,
      "points" : [ {
        "x" : 1644,
        "y" : 822
      } ],
      "stoichiometry" : 6
    }, {
      "id" : 52875,
      "points" : [ {
        "x" : 1524,
        "y" : 870
      } ]
    } ],
    "outputs" : [ {
      "id" : 52889,
      "points" : [ {
        "x" : 1693,
        "y" : 822
      } ],
      "stoichiometry" : 6
    }, {
      "id" : 52883,
      "points" : [ {
        "x" : 1692,
        "y" : 905
      } ],
      "stoichiometry" : 2
    }, {
      "id" : 52873,
      "points" : [ {
        "x" : 1530,
        "y" : 773
      }, {
        "x" : 1585,
        "y" : 751
      }, {
        "x" : 1723,
        "y" : 750
      }, {
        "x" : 1725,
        "y" : 856
      } ]
    } ],
    "catalysts" : [ {
      "id" : 52875,
      "points" : [ {
        "x" : 1524,
        "y" : 877
      }, {
        "x" : 1669,
        "y" : 875
      } ]
    } ]
  }, {
    "id" : 52890,
    "reactomeId" : 9997054,
    "displayName" : "K63-linked ubiquitination of RIP1 bound to the activated TLR complex",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 34,
      "y" : 854
    },
    "minX" : 28,
    "maxX" : 122,
    "minY" : 547,
    "maxY" : 860,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 81,
        "y" : 547
      },
      "to" : {
        "x" : 33,
        "y" : 562
      }
    }, {
      "from" : {
        "x" : 33,
        "y" : 562
      },
      "to" : {
        "x" : 34,
        "y" : 854
      }
    }, {
      "from" : {
        "x" : 34,
        "y" : 854
      },
      "to" : {
        "x" : 122,
        "y" : 854
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 115,
        "y" : 858
      },
      "b" : {
        "x" : 122,
        "y" : 854
      },
      "c" : {
        "x" : 115,
        "y" : 850
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 115,
        "y" : 850
      }
    },
    "reactionShape" : {
      "a" : {
        "x" : 28,
        "y" : 848
      },
      "b" : {
        "x" : 40,
        "y" : 860
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 34,
        "y" : 854
      }
    },
    "inputs" : [ {
      "id" : 52891,
      "points" : [ {
        "x" : 63,
        "y" : 508
      } ],
      "stoichiometry" : 2
    }, {
      "id" : 52879,
      "points" : [ {
        "x" : 98,
        "y" : 544
      } ]
    } ],
    "outputs" : [ {
      "id" : 52892
    } ],
    "catalysts" : [ {
      "id" : 52893,
      "points" : [ {
        "x" : 84,
        "y" : 893
      } ]
    } ]
  }, {
    "id" : 52955,
    "reactomeId" : 10093616,
    "displayName" : "OPTN binds TBK1 within the activated TLR4 complex",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 1529,
      "y" : 571
    },
    "minX" : 1515,
    "maxX" : 1535,
    "minY" : 553,
    "maxY" : 578,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 1530,
        "y" : 553
      },
      "to" : {
        "x" : 1529,
        "y" : 571
      }
    }, {
      "from" : {
        "x" : 1529,
        "y" : 571
      },
      "to" : {
        "x" : 1515,
        "y" : 578
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 1519,
        "y" : 571
      },
      "b" : {
        "x" : 1515,
        "y" : 578
      },
      "c" : {
        "x" : 1523,
        "y" : 578
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 1523,
        "y" : 578
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 1529,
        "y" : 571
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 1529,
        "y" : 571
      }
    },
    "inputs" : [ {
      "id" : 52956,
      "points" : [ {
        "x" : 1544,
        "y" : 553
      } ]
    }, {
      "id" : 52945,
      "points" : [ {
        "x" : 1508,
        "y" : 535
      } ]
    } ],
    "outputs" : [ {
      "id" : 52954
    } ]
  }, {
    "id" : 52957,
    "reactomeId" : 10093626,
    "displayName" : "IKKε (IKBKE) is ubiquitinated within the activated TLR4",
    "schemaClass" : "BlackBoxEvent",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 1410,
      "y" : 985
    },
    "minX" : 1219,
    "maxX" : 1416,
    "minY" : 964,
    "maxY" : 992,
    "reactionType" : "omitted",
    "segments" : [ {
      "from" : {
        "x" : 1409,
        "y" : 964
      },
      "to" : {
        "x" : 1410,
        "y" : 985
      }
    }, {
      "from" : {
        "x" : 1410,
        "y" : 985
      },
      "to" : {
        "x" : 1229,
        "y" : 985
      }
    }, {
      "from" : {
        "x" : 1229,
        "y" : 985
      },
      "to" : {
        "x" : 1219,
        "y" : 992
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 1222,
        "y" : 985
      },
      "b" : {
        "x" : 1219,
        "y" : 992
      },
      "c" : {
        "x" : 1227,
        "y" : 991
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 1227,
        "y" : 991
      }
    },
    "reactionShape" : {
      "a" : {
        "x" : 1404,
        "y" : 979
      },
      "b" : {
        "x" : 1416,
        "y" : 991
      },
      "s" : "\\\\",
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 1410,
        "y" : 985
      }
    },
    "inputs" : [ {
      "id" : 52942,
      "points" : [ {
        "x" : 1398,
        "y" : 289
      }, {
        "x" : 1350,
        "y" : 288
      }, {
        "x" : 1356,
        "y" : 918
      } ]
    }, {
      "id" : 52938,
      "points" : [ {
        "x" : 1532,
        "y" : 927
      } ]
    } ],
    "outputs" : [ {
      "id" : 52958
    } ]
  }, {
    "id" : 52894,
    "reactomeId" : 10022854,
    "displayName" : "IKBKG subunit of IKK complex binds polyubiquinated RIP1",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 162,
      "y" : 960
    },
    "minX" : 156,
    "maxX" : 168,
    "minY" : 944,
    "maxY" : 979,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 162,
        "y" : 944
      },
      "to" : {
        "x" : 162,
        "y" : 960
      }
    }, {
      "from" : {
        "x" : 162,
        "y" : 960
      },
      "to" : {
        "x" : 167,
        "y" : 979
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 161,
        "y" : 973
      },
      "b" : {
        "x" : 167,
        "y" : 979
      },
      "c" : {
        "x" : 169,
        "y" : 971
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 169,
        "y" : 971
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 162,
        "y" : 960
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 162,
        "y" : 960
      }
    },
    "inputs" : [ {
      "id" : 52895,
      "points" : [ {
        "x" : 150,
        "y" : 944
      } ]
    }, {
      "id" : 52892,
      "points" : [ {
        "x" : 182,
        "y" : 883
      } ]
    } ],
    "outputs" : [ {
      "id" : 52896
    } ]
  }, {
    "id" : 52959,
    "reactomeId" : 10093601,
    "displayName" : "TBK1 is ubiquitinated within TBK1:K63polyUb-TANK:K63polyUb-TRAF3:TRIF:activated TLR4",
    "schemaClass" : "BlackBoxEvent",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 1444,
      "y" : 987
    },
    "minX" : 1379,
    "maxX" : 1450,
    "minY" : 966,
    "maxY" : 1015,
    "reactionType" : "omitted",
    "segments" : [ {
      "from" : {
        "x" : 1443,
        "y" : 966
      },
      "to" : {
        "x" : 1444,
        "y" : 987
      }
    }, {
      "from" : {
        "x" : 1444,
        "y" : 987
      },
      "to" : {
        "x" : 1379,
        "y" : 1015
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 1384,
        "y" : 1009
      },
      "b" : {
        "x" : 1379,
        "y" : 1015
      },
      "c" : {
        "x" : 1387,
        "y" : 1016
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 1387,
        "y" : 1016
      }
    },
    "reactionShape" : {
      "a" : {
        "x" : 1438,
        "y" : 981
      },
      "b" : {
        "x" : 1450,
        "y" : 993
      },
      "s" : "\\\\",
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 1444,
        "y" : 987
      }
    },
    "inputs" : [ {
      "id" : 52945,
      "points" : [ {
        "x" : 1409,
        "y" : 526
      }, {
        "x" : 1371,
        "y" : 550
      }, {
        "x" : 1370,
        "y" : 914
      } ]
    }, {
      "id" : 52938,
      "points" : [ {
        "x" : 1532,
        "y" : 928
      } ]
    } ],
    "outputs" : [ {
      "id" : 52960
    } ]
  }, {
    "id" : 52897,
    "reactomeId" : 10022842,
    "displayName" : "Activated TLR4:TICAM1 recruits TRAF6",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 828,
      "y" : 150
    },
    "minX" : 798,
    "maxX" : 855,
    "minY" : 144,
    "maxY" : 169,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 798,
        "y" : 150
      },
      "to" : {
        "x" : 828,
        "y" : 150
      }
    }, {
      "from" : {
        "x" : 828,
        "y" : 150
      },
      "to" : {
        "x" : 855,
        "y" : 169
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 847,
        "y" : 168
      },
      "b" : {
        "x" : 855,
        "y" : 169
      },
      "c" : {
        "x" : 852,
        "y" : 162
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 852,
        "y" : 162
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 828,
        "y" : 150
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 828,
        "y" : 150
      }
    },
    "inputs" : [ {
      "id" : 52898,
      "points" : [ {
        "x" : 796,
        "y" : 135
      } ]
    }, {
      "id" : 52871,
      "points" : [ {
        "x" : 744,
        "y" : 165
      } ]
    } ],
    "outputs" : [ {
      "id" : 52899
    } ],
    "inhibitors" : [ {
      "id" : 52881,
      "points" : [ {
        "x" : 184,
        "y" : 179
      }, {
        "x" : 174,
        "y" : 54
      }, {
        "x" : 828,
        "y" : 55
      } ]
    } ]
  }, {
    "id" : 52900,
    "reactomeId" : 10022834,
    "displayName" : "Auto ubiquitination of TRAF6 bound to the activated TLR4 complex",
    "schemaClass" : "BlackBoxEvent",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 956,
      "y" : 1013
    },
    "minX" : 877,
    "maxX" : 965,
    "minY" : 156,
    "maxY" : 1036,
    "reactionType" : "omitted",
    "segments" : [ {
      "from" : {
        "x" : 965,
        "y" : 156
      },
      "to" : {
        "x" : 956,
        "y" : 1013
      }
    }, {
      "from" : {
        "x" : 956,
        "y" : 1013
      },
      "to" : {
        "x" : 877,
        "y" : 1036
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 883,
        "y" : 1030
      },
      "b" : {
        "x" : 877,
        "y" : 1036
      },
      "c" : {
        "x" : 885,
        "y" : 1038
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 885,
        "y" : 1038
      }
    },
    "reactionShape" : {
      "a" : {
        "x" : 950,
        "y" : 1007
      },
      "b" : {
        "x" : 962,
        "y" : 1019
      },
      "s" : "\\\\",
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 956,
        "y" : 1013
      }
    },
    "inputs" : [ {
      "id" : 52899,
      "points" : [ {
        "x" : 935,
        "y" : 169
      } ]
    }, {
      "id" : 52901,
      "points" : [ {
        "x" : 938,
        "y" : 134
      } ],
      "stoichiometry" : 3
    } ],
    "outputs" : [ {
      "id" : 52902
    } ]
  }, {
    "id" : 52903,
    "reactomeId" : 10022825,
    "displayName" : "Activated TLR4:TICAM1:K63pUb-TRAF6 recruits TAK1complex",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 714,
      "y" : 1102
    },
    "minX" : 698,
    "maxX" : 737,
    "minY" : 1094,
    "maxY" : 1108,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 737,
        "y" : 1102
      },
      "to" : {
        "x" : 714,
        "y" : 1102
      }
    }, {
      "from" : {
        "x" : 714,
        "y" : 1102
      },
      "to" : {
        "x" : 698,
        "y" : 1094
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 706,
        "y" : 1094
      },
      "b" : {
        "x" : 698,
        "y" : 1094
      },
      "c" : {
        "x" : 702,
        "y" : 1101
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 702,
        "y" : 1101
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 714,
        "y" : 1102
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 714,
        "y" : 1102
      }
    },
    "inputs" : [ {
      "id" : 52904,
      "points" : [ {
        "x" : 747,
        "y" : 1128
      } ],
      "stoichiometry" : 2
    }, {
      "id" : 52902,
      "points" : [ {
        "x" : 769,
        "y" : 1085
      } ]
    }, {
      "id" : 52905,
      "points" : [ {
        "x" : 1475,
        "y" : 1110
      }, {
        "x" : 800,
        "y" : 1109
      } ],
      "stoichiometry" : 2
    } ],
    "outputs" : [ {
      "id" : 52906
    } ]
  }, {
    "id" : 52907,
    "reactomeId" : 10022830,
    "displayName" : "Activation of TAK1 complex bound to activated TLR4 complex",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 568,
      "y" : 1113
    },
    "minX" : 548,
    "maxX" : 588,
    "minY" : 1107,
    "maxY" : 1119,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 588,
        "y" : 1113
      },
      "to" : {
        "x" : 568,
        "y" : 1113
      }
    }, {
      "from" : {
        "x" : 568,
        "y" : 1113
      },
      "to" : {
        "x" : 548,
        "y" : 1113
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 562,
        "y" : 1107
      },
      "b" : {
        "x" : 574,
        "y" : 1119
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 568,
        "y" : 1113
      }
    },
    "inputs" : [ {
      "id" : 52906,
      "points" : [ {
        "x" : 615,
        "y" : 1094
      } ]
    }, {
      "id" : 52908,
      "points" : [ {
        "x" : 612,
        "y" : 1132
      } ],
      "stoichiometry" : 4
    } ],
    "outputs" : [ {
      "id" : 52909,
      "points" : [ {
        "x" : 524,
        "y" : 1094
      } ]
    }, {
      "id" : 52910,
      "points" : [ {
        "x" : 520,
        "y" : 1134
      } ],
      "stoichiometry" : 4
    } ],
    "catalysts" : [ {
      "id" : 52906,
      "points" : [ {
        "x" : 587,
        "y" : 1083
      }, {
        "x" : 569,
        "y" : 1092
      } ]
    } ]
  }, {
    "id" : 52911,
    "reactomeId" : 10022876,
    "displayName" : "Phosphorylated TAK1 leaves activated TLR receptor complex",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 391,
      "y" : 1007
    },
    "minX" : 346,
    "maxX" : 414,
    "minY" : 1001,
    "maxY" : 1019,
    "reactionType" : "dissociation",
    "segments" : [ {
      "from" : {
        "x" : 414,
        "y" : 1019
      },
      "to" : {
        "x" : 391,
        "y" : 1007
      }
    }, {
      "from" : {
        "x" : 391,
        "y" : 1007
      },
      "to" : {
        "x" : 346,
        "y" : 1006
      }
    } ],
    "reactionShape" : {
      "c" : {
        "x" : 391,
        "y" : 1007
      },
      "r" : 5,
      "r1" : 3,
      "type" : "DOUBLE_CIRCLE",
      "empty" : true,
      "centre" : {
        "x" : 391,
        "y" : 1007
      }
    },
    "inputs" : [ {
      "id" : 52909
    } ],
    "outputs" : [ {
      "id" : 52912,
      "points" : [ {
        "x" : 327,
        "y" : 1024
      } ]
    }, {
      "id" : 52871,
      "points" : [ {
        "x" : 668,
        "y" : 205
      } ]
    } ]
  }, {
    "id" : 52913,
    "reactomeId" : 10043632,
    "displayName" : "TRAF3 binds TICAM1:activated TLR4 complex",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 1039,
      "y" : 97
    },
    "minX" : 778,
    "maxX" : 1045,
    "minY" : 91,
    "maxY" : 155,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 778,
        "y" : 97
      },
      "to" : {
        "x" : 1039,
        "y" : 97
      }
    }, {
      "from" : {
        "x" : 1039,
        "y" : 97
      },
      "to" : {
        "x" : 1039,
        "y" : 155
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 1035,
        "y" : 148
      },
      "b" : {
        "x" : 1039,
        "y" : 155
      },
      "c" : {
        "x" : 1043,
        "y" : 148
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 1043,
        "y" : 148
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 1039,
        "y" : 97
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 1039,
        "y" : 97
      }
    },
    "inputs" : [ {
      "id" : 52914,
      "points" : [ {
        "x" : 741,
        "y" : 87
      } ],
      "stoichiometry" : 2
    }, {
      "id" : 52871,
      "points" : [ {
        "x" : 697,
        "y" : 162
      } ]
    } ],
    "outputs" : [ {
      "id" : 52915
    } ],
    "inhibitors" : [ {
      "id" : 52881,
      "points" : [ {
        "x" : 183,
        "y" : 179
      }, {
        "x" : 171,
        "y" : 39
      }, {
        "x" : 1038,
        "y" : 39
      } ]
    } ]
  }, {
    "id" : 52916,
    "reactomeId" : 10043687,
    "displayName" : "Auto-ubiquitination of TRAF3",
    "schemaClass" : "BlackBoxEvent",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 1127,
      "y" : 134
    },
    "minX" : 1085,
    "maxX" : 1159,
    "minY" : 128,
    "maxY" : 158,
    "reactionType" : "omitted",
    "segments" : [ {
      "from" : {
        "x" : 1085,
        "y" : 134
      },
      "to" : {
        "x" : 1127,
        "y" : 134
      }
    }, {
      "from" : {
        "x" : 1127,
        "y" : 134
      },
      "to" : {
        "x" : 1159,
        "y" : 158
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 1151,
        "y" : 157
      },
      "b" : {
        "x" : 1159,
        "y" : 158
      },
      "c" : {
        "x" : 1156,
        "y" : 151
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 1156,
        "y" : 151
      }
    },
    "reactionShape" : {
      "a" : {
        "x" : 1121,
        "y" : 128
      },
      "b" : {
        "x" : 1133,
        "y" : 140
      },
      "s" : "\\\\",
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 1127,
        "y" : 134
      }
    },
    "inputs" : [ {
      "id" : 52915,
      "points" : [ {
        "x" : 1063,
        "y" : 155
      } ]
    }, {
      "id" : 52917,
      "points" : [ {
        "x" : 1073,
        "y" : 117
      } ]
    } ],
    "outputs" : [ {
      "id" : 52918
    } ],
    "catalysts" : [ {
      "id" : 52915,
      "points" : [ {
        "x" : 1100,
        "y" : 161
      }, {
        "x" : 1116,
        "y" : 154
      } ]
    } ]
  }, {
    "id" : 52919,
    "reactomeId" : 10045767,
    "displayName" : "SARM binds TICAM1:TRAM:TLR4:LY96:LPS:CD14",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 100,
      "y" : 207
    },
    "minX" : 94,
    "maxX" : 126,
    "minY" : 188,
    "maxY" : 213,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 100,
        "y" : 188
      },
      "to" : {
        "x" : 100,
        "y" : 207
      }
    }, {
      "from" : {
        "x" : 100,
        "y" : 207
      },
      "to" : {
        "x" : 126,
        "y" : 207
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 119,
        "y" : 211
      },
      "b" : {
        "x" : 126,
        "y" : 207
      },
      "c" : {
        "x" : 119,
        "y" : 203
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 119,
        "y" : 203
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 100,
        "y" : 207
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 100,
        "y" : 207
      }
    },
    "inputs" : [ {
      "id" : 52920,
      "points" : [ {
        "x" : 81,
        "y" : 165
      } ]
    }, {
      "id" : 52871,
      "points" : [ {
        "x" : 671,
        "y" : 162
      }, {
        "x" : 648,
        "y" : 77
      }, {
        "x" : 140,
        "y" : 77
      } ]
    } ],
    "outputs" : [ {
      "id" : 52881
    } ]
  }, {
    "id" : 52921,
    "reactomeId" : 10045842,
    "displayName" : "TLR4-induced ripoptosome assembly",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 150,
      "y" : 603
    },
    "minX" : 144,
    "maxX" : 187,
    "minY" : 584,
    "maxY" : 626,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 150,
        "y" : 584
      },
      "to" : {
        "x" : 150,
        "y" : 603
      }
    }, {
      "from" : {
        "x" : 150,
        "y" : 603
      },
      "to" : {
        "x" : 187,
        "y" : 626
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 179,
        "y" : 626
      },
      "b" : {
        "x" : 187,
        "y" : 626
      },
      "c" : {
        "x" : 183,
        "y" : 619
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 183,
        "y" : 619
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 150,
        "y" : 603
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 150,
        "y" : 603
      }
    },
    "inputs" : [ {
      "id" : 52879,
      "points" : [ {
        "x" : 156,
        "y" : 564
      } ]
    }, {
      "id" : 52922,
      "points" : [ {
        "x" : 115,
        "y" : 584
      } ],
      "stoichiometry" : 2
    }, {
      "id" : 52923,
      "points" : [ {
        "x" : 113,
        "y" : 613
      } ],
      "stoichiometry" : 2
    } ],
    "outputs" : [ {
      "id" : 52924
    } ],
    "inhibitors" : [ {
      "id" : 52892,
      "points" : [ {
        "x" : 258,
        "y" : 853
      }, {
        "x" : 305,
        "y" : 853
      }, {
        "x" : 305,
        "y" : 602
      } ]
    } ]
  }, {
    "id" : 52925,
    "reactomeId" : 10045848,
    "displayName" : "Caspase-8 processing within TLR4 complex",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 168,
      "y" : 700
    },
    "minX" : 162,
    "maxX" : 193,
    "minY" : 683,
    "maxY" : 720,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 193,
        "y" : 683
      },
      "to" : {
        "x" : 168,
        "y" : 700
      }
    }, {
      "from" : {
        "x" : 168,
        "y" : 700
      },
      "to" : {
        "x" : 166,
        "y" : 720
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 162,
        "y" : 694
      },
      "b" : {
        "x" : 174,
        "y" : 706
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 168,
        "y" : 700
      }
    },
    "inputs" : [ {
      "id" : 52924
    } ],
    "outputs" : [ {
      "id" : 52926,
      "points" : [ {
        "x" : 127,
        "y" : 734
      } ]
    }, {
      "id" : 52927,
      "points" : [ {
        "x" : 194,
        "y" : 731
      } ]
    } ],
    "catalysts" : [ {
      "id" : 52924,
      "points" : [ {
        "x" : 158,
        "y" : 677
      }, {
        "x" : 148,
        "y" : 682
      } ]
    } ]
  } ],
  "compartments" : [ {
    "id" : 52961,
    "reactomeId" : 70101,
    "displayName" : "cytosol",
    "schemaClass" : "Compartment",
    "renderableClass" : "Compartment",
    "position" : {
      "x" : 893,
      "y" : 618
    },
    "minX" : 0,
    "maxX" : 1787,
    "minY" : 0,
    "maxY" : 1237,
    "prop" : {
      "x" : 0,
      "y" : 0,
      "width" : 1787,
      "height" : 1237
    },
    "textPosition" : {
      "x" : 24,
      "y" : 36
    },
    "insets" : {
      "x" : 10,
      "y" : 10,
      "width" : 1767,
      "height" : 1217
    },
    "bgColor" : {
      "r" : 250,
      "g" : 240,
      "b" : 240
    },
    "componentIds" : [ 52965, 52889, 52878, 52886, 52886, 52886, 52886, 52886, 52886, 52886, 52886, 52886, 52886, 52886, 52886, 52886, 52886, 52877, 52886, 52886, 52886, 52886, 52886, 52886, 52886, 52886, 52886, 52886, 52886, 52886, 52886, 52886, 52886, 52886, 52886, 52886, 52886, 52886, 52886, 52886, 52886, 52886, 52886, 52886, 52886, 52886, 52886, 52886, 52886, 52886, 52886, 52886, 52886, 52886, 52886, 52886, 52886, 52886, 52886, 52886, 52886, 52886, 52885, 52920, 52962, 52886, 52883, 52882, 52885, 52885, 52885, 52885, 52885, 52885, 52886, 52886, 52886, 52886, 52886, 52885, 52886, 52885, 52885, 52886, 52886, 52885, 52886, 52885, 52886, 52885, 52886, 52886, 52885, 52886, 52886, 52886, 52886, 52886, 52885, 52885, 52886, 52886, 52885, 52886, 52885, 52886, 52885, 52886, 52886, 52886, 52885, 52886, 52886, 52886, 52886, 52886, 52885, 52885, 52886, 52886, 52885, 52886, 52885, 52886, 52885, 52886, 52886, 52886, 52885, 52872, 52874, 52887, 52886, 52886, 52886, 52886, 52885, 52886, 52886, 52885, 52886, 52885, 52886, 52885, 52886, 52886, 52886, 52885, 52885, 52886, 52885, 52886, 52921, 52922, 52923, 52886, 52886, 52886, 52886, 52886, 52886, 52886, 52886, 52886, 52886, 52886, 52886, 52886, 52886, 52886, 52886, 52886, 52886, 52886, 52886, 52886, 52886, 52886, 52886, 52886, 52886, 52886, 52886, 52886, 52886, 52886, 52886, 52886, 52886, 52886, 52886, 52886, 52886, 52886, 52886, 52886, 52886, 52886, 52886, 52886, 52886, 52886, 52886, 52886, 52886, 52886, 52886, 52886, 52886, 52886, 52886, 52886, 52886, 52886, 52886, 52886, 52886, 52886, 52886, 52886, 52886, 52886, 52886, 52886, 52886, 52886, 52886, 52886, 52886, 52886, 52886, 52886, 52886, 52886, 52886, 52886, 52886, 52886, 52886, 52886, 52886, 52886, 52886, 52886, 52886, 52886, 52886, 52886, 52886, 52886, 52886, 52886, 52886, 52886, 52886, 52886, 52886, 52886, 52886, 52885, 52885, 52885, 52885, 52885, 52885, 52885, 52885, 52938, 52886, 52886, 52886, 52886, 52886, 52886, 52885, 52886, 52886, 52886, 52885, 52885, 52886, 52885, 52886, 52885, 52886, 52886, 52885, 52885, 52885, 52886, 52886, 52886, 52886, 52886, 52886, 52886, 52885, 52886, 52886, 52886, 52885, 52885, 52886, 52885, 52886, 52885, 52886, 52886, 52885, 52885, 52885, 52886, 52886, 52886, 52886, 52886, 52886, 52886, 52885, 52886, 52886, 52886, 52885, 52885, 52886, 52885, 52886, 52885, 52886, 52886, 52885, 52885, 52885, 52886, 52885, 52885, 52885, 52885, 52885, 52885, 52885, 52885, 52886, 52886, 52886, 52886, 52886, 52886, 52886, 52886, 52886, 52886, 52886, 52886, 52886, 52886, 52886, 52886, 52886, 52886, 52886, 52886, 52886, 52886, 52886, 52886, 52886, 52886, 52886, 52886, 52886, 52886, 52886, 52886, 52886, 52886, 52886, 52886, 52886, 52886, 52886, 52886, 52886, 52886, 52886, 52886, 52886, 52886, 52886, 52886, 52886, 52886, 52886, 52886, 52886, 52886, 52886, 52886, 52886, 52886, 52886, 52886, 52886, 52886, 52886, 52886, 52886, 52886, 52886, 52886, 52886, 52886, 52886, 52886, 52886, 52886, 52886, 52886, 52886, 52886, 52886, 52886, 52886, 52886, 52886, 52886, 52886, 52886, 52886, 52886, 52886, 52886, 52886, 52886, 52886, 52886, 52886, 52886, 52886, 52886, 52886, 52886, 52886, 52886, 52886, 52886, 52886, 52886, 52885, 52885, 52886, 52885, 52886, 52885, 52886, 52886, 52885, 52885, 52885, 52886, 52886, 52885, 52886, 52886, 52886, 52886, 52886, 52886, 52886, 52886, 52885, 52885, 52886, 52885, 52886, 52885, 52886, 52886, 52885, 52885, 52885, 52886, 52886, 52885, 52886, 52886, 52886, 52886, 52886, 52886, 52886, 52886, 52885, 52885, 52886, 52885, 52886, 52885, 52886, 52886, 52885, 52885, 52885, 52886, 52886, 52885, 52886, 52886, 52886, 52886, 52886, 52886, 52886, 52886, 52885, 52885, 52886, 52885, 52886, 52885, 52886, 52886, 52885, 52885, 52885, 52886, 52886, 52885, 52886, 52886, 52886, 52886, 52886, 52886, 52886, 52886, 52885, 52885, 52886, 52885, 52886, 52885, 52886, 52886, 52885, 52885, 52885, 52886, 52886, 52885, 52886, 52886, 52886, 52886, 52886, 52886, 52886, 52886, 52885, 52885, 52886, 52885, 52886, 52885, 52886, 52886, 52885, 52885, 52885, 52886, 52886, 52885, 52886, 52886, 52886, 52886, 52886, 52886, 52886, 52886, 52885, 52885, 52886, 52885, 52886, 52885, 52886, 52886, 52885, 52885, 52885, 52886, 52886, 52885, 52886, 52886, 52886, 52886, 52886, 52886, 52886, 52886, 52885, 52885, 52886, 52885, 52886, 52885, 52886, 52886, 52885, 52885, 52885, 52886, 52886, 52885, 52886, 52886, 52886, 52886, 52886, 52886, 52886, 52886, 52885, 52885, 52886, 52885, 52886, 52885, 52886, 52886, 52885, 52885, 52885, 52886, 52886, 52885, 52886, 52886, 52886, 52886, 52886, 52886, 52886, 52886, 52885, 52885, 52886, 52885, 52886, 52885, 52886, 52886, 52885, 52885, 52885, 52886, 52886, 52885, 52886, 52886, 52886, 52886, 52886, 52886, 52886, 52886, 52885, 52885, 52886, 52885, 52886, 52885, 52886, 52886, 52885, 52885, 52885, 52886, 52886, 52885, 52886, 52886, 52886, 52886, 52886, 52886, 52886, 52886, 52885, 52885, 52886, 52885, 52886, 52885, 52886, 52886, 52885, 52885, 52885, 52886, 52886, 52885, 52886, 52886, 52886, 52886, 52886, 52886, 52886, 52886, 52885, 52885, 52886, 52885, 52886, 52885, 52886, 52886, 52885, 52885, 52885, 52886, 52886, 52885, 52886, 52886, 52886, 52886, 52886, 52886, 52886, 52886, 52885, 52885, 52886, 52885, 52886, 52885, 52886, 52886, 52885, 52885, 52885, 52886, 52886, 52885, 52876, 52928, 52935, 52919, 52885, 52885, 52885, 52885, 52885, 52885, 52885, 52885, 52885, 52885, 52885, 52885, 52885, 52885, 52885, 52885, 52885, 52885, 52885, 52885, 52885, 52885, 52885, 52885, 52885, 52885, 52885, 52885, 52885, 52885, 52885, 52885, 52886, 52886, 52886, 52886, 52886, 52886, 52886, 52886, 52885, 52886, 52885, 52886, 52885, 52886, 52886, 52885, 52885, 52885, 52886, 52886, 52885, 52886, 52885, 52885, 52885, 52885, 52885, 52885, 52885, 52885, 52885, 52885, 52885, 52885, 52885, 52885, 52885, 52885, 52885, 52885, 52885, 52885, 52885, 52885, 52885, 52885, 52885, 52885, 52885, 52885, 52885, 52885, 52885, 52885, 52885, 52885, 52885, 52885, 52885, 52885, 52885, 52885, 52885, 52886, 52886, 52886, 52886, 52886, 52886, 52886, 52885, 52886, 52885, 52886, 52885, 52886, 52886, 52885, 52885, 52885, 52886, 52886, 52885, 52886, 52885, 52886, 52884, 52937, 52905, 52886, 52886, 52886, 52886, 52886, 52886, 52885, 52886, 52885, 52886, 52886, 52885, 52885, 52885, 52886, 52886, 52885, 52886, 52885, 52886, 52886, 52885, 52886, 52885, 52910, 52963, 52964, 52907, 52968, 52969, 52970, 52925, 52903, 52904, 52908, 52886, 52886, 52886, 52886, 52886, 52886, 52886, 52886, 52886, 52886, 52886, 52886, 52886, 52886, 52886, 52886, 52886, 52886, 52886, 52886, 52886, 52886, 52886, 52886, 52886, 52886, 52886, 52886, 52886, 52886, 52886, 52886, 52886, 52886, 52886, 52886, 52885, 52886, 52886, 52885, 52885, 52885, 52886, 52886, 52885, 52886, 52885, 52886, 52886, 52885, 52886, 52885, 52886, 52886, 52885, 52886, 52886, 52886, 52886, 52886, 52886, 52885, 52886, 52886, 52885, 52885, 52885, 52886, 52886, 52885, 52886, 52885, 52886, 52886, 52885, 52886, 52885, 52886, 52886, 52885, 52886, 52886, 52886, 52886, 52886, 52886, 52885, 52886, 52886, 52885, 52885, 52885, 52886, 52886, 52885, 52886, 52885, 52886, 52886, 52885, 52886, 52885, 52886, 52886, 52885, 52886, 52886, 52885, 52885, 52885, 52885, 52885, 52885, 52885, 52885, 52885, 52885, 52885, 52885, 52885, 52885, 52885, 52885, 52885, 52885, 52886, 52886, 52886, 52886, 52886, 52885, 52885, 52886, 52886, 52885, 52886, 52885, 52886, 52886, 52885, 52886, 52885, 52886, 52886, 52885, 52886, 52886, 52885, 52886, 52885, 52870, 52898, 52914, 52917, 52932, 52868, 52897, 52913, 52916, 52931, 52934, 52886, 52886, 52886, 52886, 52886, 52886, 52886, 52886, 52886, 52886, 52886, 52886, 52886, 52886, 52886, 52886, 52886, 52941, 52940, 52944, 52943, 52947, 52946, 52948, 52952, 52951, 52950, 52880, 52928, 52888, 52886, 52886, 52886, 52886, 52886, 52885, 52886, 52885, 52886, 52886, 52885, 52886, 52885, 52886, 52886, 52885, 52886, 52886, 52885, 52886, 52885, 52885, 52886, 52885, 52886, 52886, 52886, 52886, 52886, 52886, 52886, 52885, 52886, 52885, 52886, 52886, 52885, 52886, 52885, 52886, 52886, 52885, 52886, 52886, 52885, 52886, 52885, 52885, 52886, 52885, 52886, 52886, 52886, 52886, 52886, 52886, 52886, 52885, 52886, 52885, 52886, 52886, 52885, 52886, 52885, 52886, 52886, 52885, 52886, 52886, 52885, 52886, 52885, 52885, 52886, 52885, 52886, 52886, 52956, 52955, 52926, 52966, 52891, 52895, 52890, 52893, 52894, 52974, 52967, 52973, 52972, 52901 ]
  }, {
    "id" : 52962,
    "reactomeId" : 7660,
    "displayName" : "nucleoplasm",
    "schemaClass" : "Compartment",
    "renderableClass" : "Compartment",
    "position" : {
      "x" : 1665,
      "y" : 1140
    },
    "minX" : 1565,
    "maxX" : 1765,
    "minY" : 1070,
    "maxY" : 1211,
    "prop" : {
      "x" : 1565,
      "y" : 1070,
      "width" : 200,
      "height" : 141
    },
    "textPosition" : {
      "x" : 1577,
      "y" : 1080
    },
    "insets" : {
      "x" : 1575,
      "y" : 1080,
      "width" : 180,
      "height" : 121
    },
    "bgColor" : {
      "r" : 250,
      "g" : 240,
      "b" : 240
    },
    "componentIds" : [ 52886, 52886, 52886, 52886, 52886, 52886, 52885, 52886, 52886, 52885, 52886, 52885, 52886, 52886, 52885, 52886, 52886, 52885, 52886, 52885, 52885, 52886, 52885, 52886, 52886, 52886, 52885, 52885 ]
  }, {
    "id" : 52965,
    "reactomeId" : 171907,
    "displayName" : "endosome lumen",
    "schemaClass" : "Compartment",
    "renderableClass" : "Compartment",
    "position" : {
      "x" : 840,
      "y" : 614
    },
    "minX" : 185,
    "maxX" : 1496,
    "minY" : 178,
    "maxY" : 1050,
    "prop" : {
      "x" : 185,
      "y" : 178,
      "width" : 1311,
      "height" : 872
    },
    "textPosition" : {
      "x" : 320,
      "y" : 268
    },
    "insets" : {
      "x" : 195,
      "y" : 188,
      "width" : 1291,
      "height" : 852
    },
    "bgColor" : {
      "r" : 250,
      "g" : 240,
      "b" : 240
    },
    "componentIds" : [ 52902, 52906, 52909, 52899, 52892, 52879, 52869, 52871, 52915, 52912, 52881, 52875, 52873, 52918, 52927, 52929, 52971, 52930, 52924, 52911, 52936, 52939, 52900, 52933, 52942, 52945, 52949, 52953, 52954, 52896, 52957, 52958, 52959, 52960 ]
  } ],
  "notes" : [ ],
  "links" : [ {
    "id" : 52968,
    "renderableClass" : "Interaction",
    "position" : {
      "x" : 350,
      "y" : 1100
    },
    "minX" : 329,
    "maxX" : 371,
    "minY" : 1081,
    "maxY" : 1119,
    "interactionType" : "Activate",
    "segments" : [ {
      "from" : {
        "x" : 329,
        "y" : 1081
      },
      "to" : {
        "x" : 371,
        "y" : 1119
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 363,
        "y" : 1117
      },
      "b" : {
        "x" : 371,
        "y" : 1119
      },
      "c" : {
        "x" : 369,
        "y" : 1111
      },
      "type" : "ARROW",
      "empty" : true,
      "centre" : {
        "x" : 369,
        "y" : 1111
      }
    },
    "reactionShape" : {
      "a" : {
        "x" : 344,
        "y" : 1094
      },
      "b" : {
        "x" : 356,
        "y" : 1106
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 350,
        "y" : 1100
      }
    },
    "inputs" : [ {
      "id" : 52912
    } ],
    "outputs" : [ {
      "id" : 52963
    } ]
  }, {
    "id" : 52969,
    "renderableClass" : "Interaction",
    "position" : {
      "x" : 269,
      "y" : 1101
    },
    "minX" : 253,
    "maxX" : 285,
    "minY" : 1081,
    "maxY" : 1122,
    "interactionType" : "Activate",
    "segments" : [ {
      "from" : {
        "x" : 285,
        "y" : 1081
      },
      "to" : {
        "x" : 253,
        "y" : 1122
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 254,
        "y" : 1114
      },
      "b" : {
        "x" : 253,
        "y" : 1122
      },
      "c" : {
        "x" : 260,
        "y" : 1119
      },
      "type" : "ARROW",
      "empty" : true,
      "centre" : {
        "x" : 260,
        "y" : 1119
      }
    },
    "reactionShape" : {
      "a" : {
        "x" : 263,
        "y" : 1095
      },
      "b" : {
        "x" : 275,
        "y" : 1107
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 269,
        "y" : 1101
      }
    },
    "inputs" : [ {
      "id" : 52912
    } ],
    "outputs" : [ {
      "id" : 52964
    } ]
  }, {
    "id" : 52970,
    "renderableClass" : "Interaction",
    "position" : {
      "x" : 203,
      "y" : 1086
    },
    "minX" : 188,
    "maxX" : 219,
    "minY" : 1050,
    "maxY" : 1122,
    "interactionType" : "Activate",
    "segments" : [ {
      "from" : {
        "x" : 188,
        "y" : 1050
      },
      "to" : {
        "x" : 219,
        "y" : 1122
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 213,
        "y" : 1117
      },
      "b" : {
        "x" : 219,
        "y" : 1122
      },
      "c" : {
        "x" : 220,
        "y" : 1114
      },
      "type" : "ARROW",
      "empty" : true,
      "centre" : {
        "x" : 220,
        "y" : 1114
      }
    },
    "reactionShape" : {
      "a" : {
        "x" : 197,
        "y" : 1080
      },
      "b" : {
        "x" : 209,
        "y" : 1092
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 203,
        "y" : 1086
      }
    },
    "inputs" : [ {
      "id" : 52896
    } ],
    "outputs" : [ {
      "id" : 52964
    } ]
  }, {
    "id" : 52971,
    "renderableClass" : "EntitySetAndMemberLink",
    "position" : {
      "x" : 275,
      "y" : 412
    },
    "minX" : 230,
    "maxX" : 281,
    "minY" : 289,
    "maxY" : 535,
    "segments" : [ {
      "from" : {
        "x" : 230,
        "y" : 535
      },
      "to" : {
        "x" : 277,
        "y" : 535
      }
    }, {
      "from" : {
        "x" : 277,
        "y" : 535
      },
      "to" : {
        "x" : 274,
        "y" : 289
      }
    }, {
      "from" : {
        "x" : 274,
        "y" : 289
      },
      "to" : {
        "x" : 265,
        "y" : 289
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 269,
        "y" : 406
      },
      "b" : {
        "x" : 281,
        "y" : 418
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 275,
        "y" : 412
      }
    },
    "inputs" : [ {
      "id" : 52879
    } ],
    "outputs" : [ {
      "id" : 52929
    } ]
  }, {
    "id" : 52972,
    "renderableClass" : "EntitySetAndMemberLink",
    "position" : {
      "x" : 1147,
      "y" : 1092
    },
    "minX" : 844,
    "maxX" : 1444,
    "minY" : 1072,
    "maxY" : 1098,
    "segments" : [ {
      "from" : {
        "x" : 844,
        "y" : 1085
      },
      "to" : {
        "x" : 862,
        "y" : 1094
      }
    }, {
      "from" : {
        "x" : 862,
        "y" : 1094
      },
      "to" : {
        "x" : 1432,
        "y" : 1091
      }
    }, {
      "from" : {
        "x" : 1432,
        "y" : 1091
      },
      "to" : {
        "x" : 1444,
        "y" : 1072
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 1141,
        "y" : 1086
      },
      "b" : {
        "x" : 1153,
        "y" : 1098
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 1147,
        "y" : 1092
      }
    },
    "inputs" : [ {
      "id" : 52902
    } ],
    "outputs" : [ {
      "id" : 52939
    } ]
  }, {
    "id" : 52973,
    "renderableClass" : "Interaction",
    "position" : {
      "x" : 152,
      "y" : 443
    },
    "minX" : 138,
    "maxX" : 167,
    "minY" : 427,
    "maxY" : 450,
    "interactionType" : "Activate",
    "segments" : [ {
      "from" : {
        "x" : 167,
        "y" : 450
      },
      "to" : {
        "x" : 152,
        "y" : 443
      }
    }, {
      "from" : {
        "x" : 152,
        "y" : 443
      },
      "to" : {
        "x" : 138,
        "y" : 427
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 146,
        "y" : 430
      },
      "b" : {
        "x" : 138,
        "y" : 427
      },
      "c" : {
        "x" : 140,
        "y" : 435
      },
      "type" : "ARROW",
      "empty" : true,
      "centre" : {
        "x" : 140,
        "y" : 435
      }
    },
    "reactionShape" : {
      "a" : {
        "x" : 146,
        "y" : 437
      },
      "b" : {
        "x" : 158,
        "y" : 449
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 152,
        "y" : 443
      }
    },
    "inputs" : [ {
      "id" : 52930
    } ],
    "outputs" : [ {
      "id" : 52967
    } ]
  }, {
    "id" : 52974,
    "renderableClass" : "Interaction",
    "position" : {
      "x" : 100,
      "y" : 770
    },
    "minX" : 94,
    "maxX" : 106,
    "minY" : 763,
    "maxY" : 778,
    "interactionType" : "Activate",
    "segments" : [ {
      "from" : {
        "x" : 100,
        "y" : 763
      },
      "to" : {
        "x" : 100,
        "y" : 778
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 96,
        "y" : 771
      },
      "b" : {
        "x" : 100,
        "y" : 778
      },
      "c" : {
        "x" : 104,
        "y" : 771
      },
      "type" : "ARROW",
      "empty" : true,
      "centre" : {
        "x" : 104,
        "y" : 771
      }
    },
    "reactionShape" : {
      "a" : {
        "x" : 94,
        "y" : 764
      },
      "b" : {
        "x" : 106,
        "y" : 776
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 100,
        "y" : 770
      }
    },
    "inputs" : [ {
      "id" : 52926
    } ],
    "outputs" : [ {
      "id" : 52966
    } ]
  } ],
  "shadows" : [ {
    "id" : 52975,
    "reactomeId" : 10099271,
    "displayName" : "TRIF (TICAM1)-mediated TLR4 signaling ",
    "schemaClass" : "Pathway",
    "renderableClass" : "Shadow",
    "position" : {
      "x" : 889,
      "y" : 619
    },
    "minX" : 13,
    "maxX" : 1766,
    "minY" : 61,
    "maxY" : 1178,
    "prop" : {
      "x" : 13,
      "y" : 61,
      "width" : 1753,
      "height" : 1117
    },
    "points" : [ {
      "x" : 13,
      "y" : 61
    }, {
      "x" : 1766,
      "y" : 61
    }, {
      "x" : 1766,
      "y" : 1178
    }, {
      "x" : 13,
      "y" : 1178
    } ],
    "colour" : "#4684ee"
  } ],
  "minX" : 0,
  "maxX" : 1787,
  "minY" : 0,
  "maxY" : 1237,
  "disease" : false
}