{ "dbId" : 10098527, "stableId" : "R-MMU-112313", "displayName" : "Neurotransmitter uptake and metabolism In glial cells", "nodes" : [ { "id" : 25872, "reactomeId" : 113592, "displayName" : "ATP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 288, "y" : 178 }, "minX" : 243, "maxX" : 334, "minY" : 162, "maxY" : 254, "prop" : { "x" : 243, "y" : 163, "width" : 90, "height" : 30 }, "textPosition" : { "x" : 272, "y" : 167 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 328, "y" : 168 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 328, "y" : 168 } } }, "connectors" : [ { "edgeId" : 25871, "type" : "INPUT", "segments" : [ { "from" : { "x" : 281, "y" : 196 }, "to" : { "x" : 255, "y" : 254 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 25873, "reactomeId" : 31633, "displayName" : "NH4+", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 187, "y" : 214 }, "minX" : 136, "maxX" : 255, "minY" : 198, "maxY" : 254, "prop" : { "x" : 136, "y" : 199, "width" : 103, "height" : 30 }, "textPosition" : { "x" : 165, "y" : 203 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 234, "y" : 204 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 234, "y" : 204 } } }, "connectors" : [ { "edgeId" : 25871, "type" : "INPUT", "segments" : [ { "from" : { "x" : 212, "y" : 232 }, "to" : { "x" : 255, "y" : 254 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 25874, "reactomeId" : 29372, "displayName" : "Pi", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 259, "y" : 463 }, "minX" : 201, "maxX" : 317, "minY" : 371, "maxY" : 485, "prop" : { "x" : 203, "y" : 441, "width" : 113, "height" : 44 }, "textPosition" : { "x" : 250, "y" : 452 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 311, "y" : 446 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 311, "y" : 446 } } }, "connectors" : [ { "edgeId" : 25871, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 245, "y" : 438 }, "to" : { "x" : 201, "y" : 371 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 238, "y" : 434 }, "b" : { "x" : 245, "y" : 438 }, "c" : { "x" : 245, "y" : 430 }, "type" : "ARROW", "centre" : { "x" : 245, "y" : 430 } } } ] }, { "id" : 25875, "reactomeId" : 70106, "displayName" : "H+", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 142, "y" : 422 }, "minX" : 124, "maxX" : 201, "minY" : 371, "maxY" : 438, "prop" : { "x" : 124, "y" : 407, "width" : 36, "height" : 31 }, "textPosition" : { "x" : 128, "y" : 412 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 155, "y" : 412 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 155, "y" : 412 } } }, "connectors" : [ { "edgeId" : 25871, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 159, "y" : 404 }, "to" : { "x" : 201, "y" : 371 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 162, "y" : 397 }, "b" : { "x" : 159, "y" : 404 }, "c" : { "x" : 167, "y" : 403 }, "type" : "ARROW", "centre" : { "x" : 167, "y" : 403 } } } ], "trivial" : true }, { "id" : 25876, "reactomeId" : 29472, "displayName" : "L-Gln", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 403, "y" : 452 }, "minX" : 201, "maxX" : 473, "minY" : 371, "maxY" : 467, "prop" : { "x" : 334, "y" : 437, "width" : 138, "height" : 30 }, "textPosition" : { "x" : 384, "y" : 441 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 467, "y" : 442 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 467, "y" : 442 } } }, "connectors" : [ { "edgeId" : 25879, "type" : "INPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 25871, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 365, "y" : 434 }, "to" : { "x" : 201, "y" : 371 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 357, "y" : 435 }, "b" : { "x" : 365, "y" : 434 }, "c" : { "x" : 360, "y" : 428 }, "type" : "ARROW", "centre" : { "x" : 360, "y" : 428 } } } ] }, { "id" : 25877, "reactomeId" : 29370, "displayName" : "ADP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 81, "y" : 344 }, "minX" : 61, "maxX" : 201, "minY" : 328, "maxY" : 371, "prop" : { "x" : 61, "y" : 329, "width" : 41, "height" : 31 }, "textPosition" : { "x" : 65, "y" : 334 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 97, "y" : 334 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 97, "y" : 334 } } }, "connectors" : [ { "edgeId" : 25871, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 105, "y" : 348 }, "to" : { "x" : 201, "y" : 371 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 113, "y" : 346 }, "b" : { "x" : 105, "y" : 348 }, "c" : { "x" : 111, "y" : 354 }, "type" : "ARROW", "centre" : { "x" : 111, "y" : 354 } } } ] }, { "id" : 25878, "reactomeId" : 9986453, "displayName" : "GLUL decamer", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 164, "y" : 285 }, "minX" : 116, "maxX" : 250, "minY" : 261, "maxY" : 304, "prop" : { "x" : 116, "y" : 267, "width" : 96, "height" : 36 }, "textPosition" : { "x" : 132, "y" : 268 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 212, "y" : 267 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 212, "y" : 267 } } }, "connectors" : [ { "edgeId" : 25871, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 215, "y" : 293 }, "to" : { "x" : 242, "y" : 299 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 246, "y" : 300 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 246, "y" : 300 } } } ] }, { "id" : 25880, "reactomeId" : 212615, "displayName" : "L-Gln", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 757, "y" : 437 }, "minX" : 690, "maxX" : 826, "minY" : 414, "maxY" : 459, "prop" : { "x" : 690, "y" : 415, "width" : 135, "height" : 44 }, "textPosition" : { "x" : 738, "y" : 426 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 820, "y" : 420 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 820, "y" : 420 } } }, "connectors" : [ { "edgeId" : 25879, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 25881, "reactomeId" : 10007127, "displayName" : "Slc38a1", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 524, "y" : 340 }, "minX" : 462, "maxX" : 593, "minY" : 309, "maxY" : 439, "prop" : { "x" : 462, "y" : 315, "width" : 125, "height" : 50 }, "textPosition" : { "x" : 495, "y" : 329 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 587, "y" : 315 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 587, "y" : 315 } } }, "connectors" : [ { "edgeId" : 25879, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 523, "y" : 368 }, "to" : { "x" : 523, "y" : 431 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 523, "y" : 435 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 523, "y" : 435 } } } ] }, { "id" : 25868, "reactomeId" : 210382, "displayName" : "L-Glu", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 739, "y" : 233 }, "minX" : 672, "maxX" : 808, "minY" : 210, "maxY" : 255, "prop" : { "x" : 672, "y" : 211, "width" : 135, "height" : 44 }, "textPosition" : { "x" : 720, "y" : 222 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 802, "y" : 216 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 802, "y" : 216 } } }, "connectors" : [ { "edgeId" : 25867, "type" : "INPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 25869, "reactomeId" : 29404, "displayName" : "L-Glu", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 371, "y" : 235 }, "minX" : 255, "maxX" : 418, "minY" : 212, "maxY" : 257, "prop" : { "x" : 325, "y" : 213, "width" : 92, "height" : 44 }, "textPosition" : { "x" : 352, "y" : 224 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 412, "y" : 218 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 412, "y" : 218 } } }, "connectors" : [ { "edgeId" : 25867, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 25871, "type" : "INPUT", "segments" : [ { "from" : { "x" : 322, "y" : 242 }, "to" : { "x" : 255, "y" : 254 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 25870, "reactomeId" : 10006585, "displayName" : "Astrocytic EAATs", "schemaClass" : "CandidateSet", "renderableClass" : "EntitySet", "position" : { "x" : 519, "y" : 112 }, "minX" : 457, "maxX" : 582, "minY" : 94, "maxY" : 224, "prop" : { "x" : 457, "y" : 94, "width" : 125, "height" : 36 }, "textPosition" : { "x" : 464, "y" : 101 }, "connectors" : [ { "edgeId" : 25867, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 518, "y" : 136 }, "to" : { "x" : 516, "y" : 216 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 516, "y" : 220 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 516, "y" : 220 } } } ] } ], "edges" : [ { "id" : 25879, "reactomeId" : 10007130, "displayName" : "Glutamine transport from astrocytes", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 523, "y" : 447 }, "minX" : 475, "maxX" : 687, "minY" : 439, "maxY" : 453, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 475, "y" : 449 }, "to" : { "x" : 523, "y" : 447 } }, { "from" : { "x" : 523, "y" : 447 }, "to" : { "x" : 687, "y" : 439 } } ], "endShape" : { "a" : { "x" : 680, "y" : 443 }, "b" : { "x" : 687, "y" : 439 }, "c" : { "x" : 680, "y" : 435 }, "type" : "ARROW", "centre" : { "x" : 680, "y" : 435 } }, "reactionShape" : { "a" : { "x" : 517, "y" : 441 }, "b" : { "x" : 529, "y" : 453 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 523, "y" : 447 } }, "inputs" : [ { "id" : 25876 } ], "outputs" : [ { "id" : 25880 } ], "catalysts" : [ { "id" : 25881, "points" : [ { "x" : 523, "y" : 368 } ] } ] }, { "id" : 25867, "reactomeId" : 10006588, "displayName" : "glutamate uptake by astrocytes", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 516, "y" : 232 }, "minX" : 420, "maxX" : 669, "minY" : 226, "maxY" : 238, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 669, "y" : 232 }, "to" : { "x" : 516, "y" : 232 } }, { "from" : { "x" : 516, "y" : 232 }, "to" : { "x" : 420, "y" : 234 } } ], "endShape" : { "a" : { "x" : 427, "y" : 230 }, "b" : { "x" : 420, "y" : 234 }, "c" : { "x" : 427, "y" : 238 }, "type" : "ARROW", "centre" : { "x" : 427, "y" : 238 } }, "reactionShape" : { "a" : { "x" : 510, "y" : 226 }, "b" : { "x" : 522, "y" : 238 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 516, "y" : 232 } }, "inputs" : [ { "id" : 25868 } ], "outputs" : [ { "id" : 25869 } ], "catalysts" : [ { "id" : 25870, "points" : [ { "x" : 518, "y" : 136 } ] } ] }, { "id" : 25871, "reactomeId" : 9986456, "displayName" : "glutamate + NH4+ + ATP => glutamine + ADP + orthophosphate [GLUL]", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 258, "y" : 302 }, "minX" : 201, "maxX" : 264, "minY" : 254, "maxY" : 371, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 255, "y" : 254 }, "to" : { "x" : 258, "y" : 302 } }, { "from" : { "x" : 258, "y" : 302 }, "to" : { "x" : 201, "y" : 371 } } ], "reactionShape" : { "a" : { "x" : 252, "y" : 296 }, "b" : { "x" : 264, "y" : 308 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 258, "y" : 302 } }, "inputs" : [ { "id" : 25869, "points" : [ { "x" : 322, "y" : 242 } ] }, { "id" : 25872, "points" : [ { "x" : 281, "y" : 196 } ] }, { "id" : 25873, "points" : [ { "x" : 212, "y" : 232 } ] } ], "outputs" : [ { "id" : 25874, "points" : [ { "x" : 245, "y" : 438 } ] }, { "id" : 25875, "points" : [ { "x" : 159, "y" : 404 } ] }, { "id" : 25876, "points" : [ { "x" : 365, "y" : 434 } ] }, { "id" : 25877, "points" : [ { "x" : 105, "y" : 348 } ] } ], "catalysts" : [ { "id" : 25878, "points" : [ { "x" : 215, "y" : 293 } ] } ] } ], "compartments" : [ { "id" : 25882, "reactomeId" : 70101, "displayName" : "cytosol", "schemaClass" : "Compartment", "renderableClass" : "Compartment", "position" : { "x" : 254, "y" : 298 }, "minX" : 0, "maxX" : 508, "minY" : 0, "maxY" : 597, "prop" : { "x" : 0, "y" : 0, "width" : 508, "height" : 597 }, "textPosition" : { "x" : 71, "y" : 532 }, "insets" : { "x" : 10, "y" : 10, "width" : 488, "height" : 577 }, "bgColor" : { "r" : 250, "g" : 240, "b" : 240 }, "componentIds" : [ 25867, 25869, 25870, 25871, 25872, 25873, 25874, 25876, 25878, 25879, 25881, 25877, 25875 ] } ], "notes" : [ ], "links" : [ ], "shadows" : [ { "id" : 25883, "reactomeId" : 10098525, "displayName" : "Astrocytic Glutamate-Glutamine Uptake And Metabolism", "schemaClass" : "Pathway", "renderableClass" : "Shadow", "position" : { "x" : 443, "y" : 289 }, "minX" : 51, "maxX" : 835, "minY" : 84, "maxY" : 495, "prop" : { "x" : 51, "y" : 84, "width" : 784, "height" : 411 }, "points" : [ { "x" : 51, "y" : 84 }, { "x" : 835, "y" : 84 }, { "x" : 835, "y" : 495 }, { "x" : 51, "y" : 495 } ], "colour" : "#4684ee" } ], "minX" : 0, "maxX" : 826, "minY" : 0, "maxY" : 597, "disease" : false }