DDB_G0267374 R-DDI-6809003 https://reactome.org/PathwayBrowser/#/R-DDI-6809003 ERGIC-to-Golgi vesicles bind dynein:dynactin IEA Dictyostelium discoideum DDB_G0267374 R-DDI-879459 https://reactome.org/PathwayBrowser/#/R-DDI-879459 F-actin capping protein is a heterodimer IEA Dictyostelium discoideum DDB_G0267374 R-DDI-994148 https://reactome.org/PathwayBrowser/#/R-DDI-994148 LRRC16A binds F-actin capping protein IEA Dictyostelium discoideum DDB_G0267378 R-DDI-1237042 https://reactome.org/PathwayBrowser/#/R-DDI-1237042 AQP1 tetramer transports CO2 from extracellular region to cytosol IEA Dictyostelium discoideum DDB_G0267378 R-DDI-1247649 https://reactome.org/PathwayBrowser/#/R-DDI-1247649 AQP1 tetramer transports CO2 from cytosol to extracellular region IEA Dictyostelium discoideum DDB_G0267378 R-DDI-432010 https://reactome.org/PathwayBrowser/#/R-DDI-432010 Aquaporin-1 passively transports water into cell IEA Dictyostelium discoideum DDB_G0267378 R-DDI-432054 https://reactome.org/PathwayBrowser/#/R-DDI-432054 Aquaporin-1 passively transports water out of cell IEA Dictyostelium discoideum DDB_G0267378 R-DDI-432065 https://reactome.org/PathwayBrowser/#/R-DDI-432065 p-S256-Aquaporin-2 passively transports water into cell IEA Dictyostelium discoideum DDB_G0267378 R-DDI-432067 https://reactome.org/PathwayBrowser/#/R-DDI-432067 Aquaporin-4 passively transports water out of cell IEA Dictyostelium discoideum DDB_G0267378 R-DDI-507868 https://reactome.org/PathwayBrowser/#/R-DDI-507868 Aquaporins passively transport water into cells IEA Dictyostelium discoideum DDB_G0267378 R-DDI-507870 https://reactome.org/PathwayBrowser/#/R-DDI-507870 Aquaporins passively transport water out of cells IEA Dictyostelium discoideum DDB_G0267384 R-DDI-1363328 https://reactome.org/PathwayBrowser/#/R-DDI-1363328 Phosphorylated p130 (RBL2) binds SCF(Skp2):Cks1 complex IEA Dictyostelium discoideum DDB_G0267384 R-DDI-1363331 https://reactome.org/PathwayBrowser/#/R-DDI-1363331 Ubiquitination of p130 (RBL2) by SCF (Skp2) IEA Dictyostelium discoideum DDB_G0267384 R-DDI-5691108 https://reactome.org/PathwayBrowser/#/R-DDI-5691108 SKP1:FBXL5:CUL1:NEDD8 ubiquitinylates IREB2 IEA Dictyostelium discoideum DDB_G0267384 R-DDI-5691131 https://reactome.org/PathwayBrowser/#/R-DDI-5691131 CANDI binds CUL1 IEA Dictyostelium discoideum DDB_G0267384 R-DDI-68946 https://reactome.org/PathwayBrowser/#/R-DDI-68946 Phosphorylated Orc1 is ubiquitinated while still associated with chromatin IEA Dictyostelium discoideum DDB_G0267384 R-DDI-8853496 https://reactome.org/PathwayBrowser/#/R-DDI-8853496 SCF:FBXL7 binds AURKA IEA Dictyostelium discoideum DDB_G0267384 R-DDI-8854041 https://reactome.org/PathwayBrowser/#/R-DDI-8854041 SCF-FBXL7 ubiquitinates AURKA IEA Dictyostelium discoideum DDB_G0267384 R-DDI-8854044 https://reactome.org/PathwayBrowser/#/R-DDI-8854044 Proteasome degrades AURKA ubiquitinated by SCF-FBXL7 IEA Dictyostelium discoideum DDB_G0267384 R-DDI-8952039 https://reactome.org/PathwayBrowser/#/R-DDI-8952039 NEDD8:AcM-UBE2F binds CRL5 E3 ubiquitin ligase complex IEA Dictyostelium discoideum DDB_G0267384 R-DDI-8952044 https://reactome.org/PathwayBrowser/#/R-DDI-8952044 AcM-UBE2F transfers NEDD8 to CRL5 E3 ubiquitin ligase complex IEA Dictyostelium discoideum DDB_G0267384 R-DDI-8952618 https://reactome.org/PathwayBrowser/#/R-DDI-8952618 AcM-UBE2M transfers NEDD8 to CRL1 E3 ubiquitin ligase complex IEA Dictyostelium discoideum DDB_G0267384 R-DDI-8952620 https://reactome.org/PathwayBrowser/#/R-DDI-8952620 NEDD8:AcM-UBE2M binds CRL1 E3 ubiquitin ligase complex IEA Dictyostelium discoideum DDB_G0267384 R-DDI-8952626 https://reactome.org/PathwayBrowser/#/R-DDI-8952626 AcM-UBE2M transfers NEDD8 to CRL2 E3 ubiquitin ligase complex IEA Dictyostelium discoideum DDB_G0267384 R-DDI-8955241 https://reactome.org/PathwayBrowser/#/R-DDI-8955241 CAND1 binds cytosolic CRL E3 ubiquitin ligases IEA Dictyostelium discoideum DDB_G0267384 R-DDI-8955289 https://reactome.org/PathwayBrowser/#/R-DDI-8955289 COMMDs displace CAND1 from cytosolic CRL E3 ubiquitin ligase complexes IEA Dictyostelium discoideum DDB_G0267384 R-DDI-8956040 https://reactome.org/PathwayBrowser/#/R-DDI-8956040 COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes IEA Dictyostelium discoideum DDB_G0267384 R-DDI-8956099 https://reactome.org/PathwayBrowser/#/R-DDI-8956099 VHL:EloB,C:NEDD8-CUL2:RBX1 complex binds UBXN7 IEA Dictyostelium discoideum DDB_G0267384 R-DDI-8956200 https://reactome.org/PathwayBrowser/#/R-DDI-8956200 MyrG-DCUN1D3 binds CRL1 E3 ubiquitin ligase complex IEA Dictyostelium discoideum DDB_G0267384 R-DDI-983140 https://reactome.org/PathwayBrowser/#/R-DDI-983140 Transfer of Ub from E2 to substrate and release of E2 IEA Dictyostelium discoideum DDB_G0267384 R-DDI-983147 https://reactome.org/PathwayBrowser/#/R-DDI-983147 Release of E3 from polyubiquitinated substrate IEA Dictyostelium discoideum DDB_G0267384 R-DDI-983156 https://reactome.org/PathwayBrowser/#/R-DDI-983156 Polyubiquitination of substrate IEA Dictyostelium discoideum DDB_G0267384 R-DDI-983157 https://reactome.org/PathwayBrowser/#/R-DDI-983157 Interaction of E3 with substrate and E2-Ub complex IEA Dictyostelium discoideum DDB_G0267386 R-DDI-1614524 https://reactome.org/PathwayBrowser/#/R-DDI-1614524 PXLP-CBS tetramers condenses HCYS and L-Ser to form L-Cystathionine IEA Dictyostelium discoideum DDB_G0267390 R-DDI-1236970 https://reactome.org/PathwayBrowser/#/R-DDI-1236970 Proteasomal clevage of exogenous antigen (26S proteasome catalyst) IEA Dictyostelium discoideum DDB_G0267390 R-DDI-1504193 https://reactome.org/PathwayBrowser/#/R-DDI-1504193 Ubiquitinated DVL is degraded by the proteasome IEA Dictyostelium discoideum DDB_G0267390 R-DDI-174058 https://reactome.org/PathwayBrowser/#/R-DDI-174058 Degradation of multiubiquitinated Cdh1 IEA Dictyostelium discoideum DDB_G0267390 R-DDI-174105 https://reactome.org/PathwayBrowser/#/R-DDI-174105 Degradation of multiubiquitinated cell cycle proteins IEA Dictyostelium discoideum DDB_G0267390 R-DDI-174202 https://reactome.org/PathwayBrowser/#/R-DDI-174202 Degradation of multiubiquitinated Securin IEA Dictyostelium discoideum DDB_G0267390 R-DDI-188191 https://reactome.org/PathwayBrowser/#/R-DDI-188191 APC/C:Cdh1-mediated degradation of Skp2 IEA Dictyostelium discoideum DDB_G0267390 R-DDI-264458 https://reactome.org/PathwayBrowser/#/R-DDI-264458 Proteasome mediated degradation of COP1 IEA Dictyostelium discoideum DDB_G0267390 R-DDI-450466 https://reactome.org/PathwayBrowser/#/R-DDI-450466 AUF1:mRNA complex is destroyed IEA Dictyostelium discoideum DDB_G0267390 R-DDI-5635854 https://reactome.org/PathwayBrowser/#/R-DDI-5635854 GLI2,3 are degraded by the proteasome IEA Dictyostelium discoideum DDB_G0267390 R-DDI-5658430 https://reactome.org/PathwayBrowser/#/R-DDI-5658430 NF1 is degraded by the proteasome IEA Dictyostelium discoideum DDB_G0267390 R-DDI-5665854 https://reactome.org/PathwayBrowser/#/R-DDI-5665854 ADRM1:26S proteaseome binds UCHL5 IEA Dictyostelium discoideum DDB_G0267390 R-DDI-5665871 https://reactome.org/PathwayBrowser/#/R-DDI-5665871 ADRM1 binds 26S proteasome IEA Dictyostelium discoideum DDB_G0267390 R-DDI-5687112 https://reactome.org/PathwayBrowser/#/R-DDI-5687112 MAPK6 is degraded by the 26S proteasome IEA Dictyostelium discoideum DDB_G0267390 R-DDI-5689539 https://reactome.org/PathwayBrowser/#/R-DDI-5689539 ADRM1:26S proteaseome binds USP14 IEA Dictyostelium discoideum DDB_G0267390 R-DDI-68948 https://reactome.org/PathwayBrowser/#/R-DDI-68948 Ubiquitinated Orc1 is degraded by the proteasome IEA Dictyostelium discoideum DDB_G0267390 R-DDI-69016 https://reactome.org/PathwayBrowser/#/R-DDI-69016 Ubiquitinated Cdc6 is degraded by the proteasome IEA Dictyostelium discoideum DDB_G0267390 R-DDI-69600 https://reactome.org/PathwayBrowser/#/R-DDI-69600 Proteolytic degradation of ubiquitinated-Cdc25A IEA Dictyostelium discoideum DDB_G0267390 R-DDI-8850992 https://reactome.org/PathwayBrowser/#/R-DDI-8850992 Proteasome degrades polyubiquitinated PTEN IEA Dictyostelium discoideum DDB_G0267390 R-DDI-8854044 https://reactome.org/PathwayBrowser/#/R-DDI-8854044 Proteasome degrades AURKA ubiquitinated by SCF-FBXL7 IEA Dictyostelium discoideum DDB_G0267390 R-DDI-8866553 https://reactome.org/PathwayBrowser/#/R-DDI-8866553 misfolded CFTR is degraded by the 26S proteasome IEA Dictyostelium discoideum DDB_G0267390 R-DDI-9755306 https://reactome.org/PathwayBrowser/#/R-DDI-9755306 ub UBXN7 is degraded by the 26S proteasome IEA Dictyostelium discoideum DDB_G0267390 R-DDI-983150 https://reactome.org/PathwayBrowser/#/R-DDI-983150 Proteasomal cleavage of substrate IEA Dictyostelium discoideum DDB_G0267390 R-DDI-9907919 https://reactome.org/PathwayBrowser/#/R-DDI-9907919 Formation of the preholoproteasome IEA Dictyostelium discoideum DDB_G0267390 R-DDI-9907925 https://reactome.org/PathwayBrowser/#/R-DDI-9907925 Formation of the inner ring of the 20S immunoproteasome core particle IEA Dictyostelium discoideum DDB_G0267390 R-DDI-9907928 https://reactome.org/PathwayBrowser/#/R-DDI-9907928 Formation of the inner ring of the 20S thymoproteasome core particle IEA Dictyostelium discoideum DDB_G0267390 R-DDI-9907940 https://reactome.org/PathwayBrowser/#/R-DDI-9907940 Formation of the preholothymoproteasome IEA Dictyostelium discoideum DDB_G0267390 R-DDI-9907941 https://reactome.org/PathwayBrowser/#/R-DDI-9907941 Fromation of the preholoimmunoproteasome IEA Dictyostelium discoideum DDB_G0267390 R-DDI-9908178 https://reactome.org/PathwayBrowser/#/R-DDI-9908178 Formation of the 26S proteasome IEA Dictyostelium discoideum DDB_G0267390 R-DDI-9908709 https://reactome.org/PathwayBrowser/#/R-DDI-9908709 Formation of the PA28-alpha-beta-20S proteasome IEA Dictyostelium discoideum DDB_G0267390 R-DDI-9908721 https://reactome.org/PathwayBrowser/#/R-DDI-9908721 Formation of the PA28gamma-20S proteasome IEA Dictyostelium discoideum DDB_G0267400 R-DDI-1497784 https://reactome.org/PathwayBrowser/#/R-DDI-1497784 The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle IEA Dictyostelium discoideum DDB_G0267400 R-DDI-1497796 https://reactome.org/PathwayBrowser/#/R-DDI-1497796 BH2 binding can lead to eNOS uncoupling IEA Dictyostelium discoideum DDB_G0267400 R-DDI-1497810 https://reactome.org/PathwayBrowser/#/R-DDI-1497810 Uncoupled eNOS favours the formation of superoxide IEA Dictyostelium discoideum DDB_G0267400 R-DDI-202111 https://reactome.org/PathwayBrowser/#/R-DDI-202111 AKT1 phosphorylates eNOS IEA Dictyostelium discoideum DDB_G0267400 R-DDI-202127 https://reactome.org/PathwayBrowser/#/R-DDI-202127 eNOS synthesizes NO IEA Dictyostelium discoideum DDB_G0267400 R-DDI-202137 https://reactome.org/PathwayBrowser/#/R-DDI-202137 AKT1 binds eNOS complex via HSP90 IEA Dictyostelium discoideum DDB_G0267400 R-DDI-3371503 https://reactome.org/PathwayBrowser/#/R-DDI-3371503 STIP1(HOP) binds HSP90 and HSP70:HSP40:nascent protein IEA Dictyostelium discoideum DDB_G0267400 R-DDI-3371586 https://reactome.org/PathwayBrowser/#/R-DDI-3371586 Dissociation of cytosolic HSF1:HSP90 complex IEA Dictyostelium discoideum DDB_G0267400 R-DDI-419644 https://reactome.org/PathwayBrowser/#/R-DDI-419644 Transphosphorylation of pLIMK1 IEA Dictyostelium discoideum DDB_G0267400 R-DDI-419645 https://reactome.org/PathwayBrowser/#/R-DDI-419645 Dimerization of LIMK1 by Hsp90 IEA Dictyostelium discoideum DDB_G0267400 R-DDI-5082356 https://reactome.org/PathwayBrowser/#/R-DDI-5082356 HSF1-mediated gene expression IEA Dictyostelium discoideum DDB_G0267400 R-DDI-5082409 https://reactome.org/PathwayBrowser/#/R-DDI-5082409 Dissociation of HSF1:HSP90 complex in the nucleus IEA Dictyostelium discoideum DDB_G0267400 R-DDI-5324632 https://reactome.org/PathwayBrowser/#/R-DDI-5324632 Dissociation of cytosolic HSF1:HSP90:HDAC6:PTGES3 upon sensing protein aggregates IEA Dictyostelium discoideum DDB_G0267400 R-DDI-5618107 https://reactome.org/PathwayBrowser/#/R-DDI-5618107 ATP binding to HSP90 triggers conformation change IEA Dictyostelium discoideum DDB_G0267400 R-DDI-6798748 https://reactome.org/PathwayBrowser/#/R-DDI-6798748 Exocytosis of secretory granule lumen proteins IEA Dictyostelium discoideum DDB_G0267400 R-DDI-6800434 https://reactome.org/PathwayBrowser/#/R-DDI-6800434 Exocytosis of ficolin-rich granule lumen proteins IEA Dictyostelium discoideum DDB_G0267400 R-DDI-874087 https://reactome.org/PathwayBrowser/#/R-DDI-874087 SGT1 binds HSP90 IEA Dictyostelium discoideum DDB_G0267400 R-DDI-8936849 https://reactome.org/PathwayBrowser/#/R-DDI-8936849 AHR:2xHSP90:AIP:PTGES3 binds TCDD IEA Dictyostelium discoideum DDB_G0267400 R-DDI-8937169 https://reactome.org/PathwayBrowser/#/R-DDI-8937169 AHR:TCDD:2xHSP90AB1:AIP:PTGES3 translocates from cytosol to nucleoplasm IEA Dictyostelium discoideum DDB_G0267402 R-DDI-2172678 https://reactome.org/PathwayBrowser/#/R-DDI-2172678 PHF8 demethylates histone H4K20me1 IEA Dictyostelium discoideum DDB_G0267402 R-DDI-2288097 https://reactome.org/PathwayBrowser/#/R-DDI-2288097 Condensin II complex binds H4K20me1-containing nucleosomes IEA Dictyostelium discoideum DDB_G0267402 R-DDI-2294580 https://reactome.org/PathwayBrowser/#/R-DDI-2294580 PLK1 hyperphosphorylates Condensin II complex IEA Dictyostelium discoideum DDB_G0267402 R-DDI-2294590 https://reactome.org/PathwayBrowser/#/R-DDI-2294590 PLK1 binds phosphorylated condensin II complex IEA Dictyostelium discoideum DDB_G0267402 R-DDI-3222593 https://reactome.org/PathwayBrowser/#/R-DDI-3222593 KDM6B demethylates H3K27me3 on p16INK4A promoter IEA Dictyostelium discoideum DDB_G0267402 R-DDI-3318413 https://reactome.org/PathwayBrowser/#/R-DDI-3318413 KAT7-containing ING4/5 complexes acetylate Me3K-histone H3 IEA Dictyostelium discoideum DDB_G0267402 R-DDI-3318486 https://reactome.org/PathwayBrowser/#/R-DDI-3318486 KAT6A, KAT6B-containing ING5 complexes acetylate replicative histone H3 IEA Dictyostelium discoideum DDB_G0267402 R-DDI-3769447 https://reactome.org/PathwayBrowser/#/R-DDI-3769447 HDAC1:2-containing complex deacetylate histones IEA Dictyostelium discoideum DDB_G0267402 R-DDI-3782637 https://reactome.org/PathwayBrowser/#/R-DDI-3782637 HDAC8 deacetylates histones IEA Dictyostelium discoideum DDB_G0267402 R-DDI-3782655 https://reactome.org/PathwayBrowser/#/R-DDI-3782655 HDAC10 deacetylates histone IEA Dictyostelium discoideum DDB_G0267402 R-DDI-427514 https://reactome.org/PathwayBrowser/#/R-DDI-427514 eNoSC deacetylates histone H3 IEA Dictyostelium discoideum DDB_G0267402 R-DDI-427527 https://reactome.org/PathwayBrowser/#/R-DDI-427527 eNoSC dimethylates histone H3 at lysine-9 IEA Dictyostelium discoideum DDB_G0267402 R-DDI-4754181 https://reactome.org/PathwayBrowser/#/R-DDI-4754181 KDM5A-D demethylate Me2K5-histone H3 IEA Dictyostelium discoideum DDB_G0267402 R-DDI-4754187 https://reactome.org/PathwayBrowser/#/R-DDI-4754187 KDM6A, KDM6B, KDM7A demethylate Me2K28-histone H3 IEA Dictyostelium discoideum DDB_G0267402 R-DDI-4827382 https://reactome.org/PathwayBrowser/#/R-DDI-4827382 SUV39H1 (KMT1A), SUV39H2 (KTM1B), SETDB1 (KMT1E), SETDB2 (KMT1F) methylate dimethyl-lysine-10 of histone H3 (H3K9) IEA Dictyostelium discoideum DDB_G0267402 R-DDI-4827383 https://reactome.org/PathwayBrowser/#/R-DDI-4827383 WHSC1 (KMT3G), NSD1 (KMT3B), SMYD2 (KMT3C) methylate lysine-37 of histone H3 (H3K36) IEA Dictyostelium discoideum DDB_G0267402 R-DDI-5159245 https://reactome.org/PathwayBrowser/#/R-DDI-5159245 SETD3, SETD7 (KMT7), WHSC1L1 (KMT3F), Core MLL complex methylate lysine-5 of histone H3 (H3K4) IEA Dictyostelium discoideum DDB_G0267402 R-DDI-5205799 https://reactome.org/PathwayBrowser/#/R-DDI-5205799 CCND1:CDK4:PRMT5:pT5-WDR77 methylates arginine-9 of histone H3 (H3R8) IEA Dictyostelium discoideum DDB_G0267402 R-DDI-5218952 https://reactome.org/PathwayBrowser/#/R-DDI-5218952 PRMT5:WDR77, PRMT7 methylate arginine-3 of histone H3 (H3R2) IEA Dictyostelium discoideum DDB_G0267402 R-DDI-5225602 https://reactome.org/PathwayBrowser/#/R-DDI-5225602 WDR5 binds Me2sR3-replicative histone H3 IEA Dictyostelium discoideum DDB_G0267402 R-DDI-5225649 https://reactome.org/PathwayBrowser/#/R-DDI-5225649 RBBP7 binds histone H3 IEA Dictyostelium discoideum DDB_G0267402 R-DDI-5244692 https://reactome.org/PathwayBrowser/#/R-DDI-5244692 Core MLL complex, SMYD3, PRDM9 methylate dimethyl-lysine-5 of histone H3 (H3K4) IEA Dictyostelium discoideum DDB_G0267402 R-DDI-5625784 https://reactome.org/PathwayBrowser/#/R-DDI-5625784 PKN1 phosphorylates histone 3 of nucleosomes associate with KLK2 and KLK3 promoters IEA Dictyostelium discoideum DDB_G0267402 R-DDI-5637686 https://reactome.org/PathwayBrowser/#/R-DDI-5637686 WHSC1L1 (KMT3F), Core MLL complex, SMYD3 (KMT3E) methylate methyl-lysine-5 of histone H3 (H3K4) IEA Dictyostelium discoideum DDB_G0267402 R-DDI-5638157 https://reactome.org/PathwayBrowser/#/R-DDI-5638157 WHSC1 (KMT3G), NSD1 (KMT3B), SMYD2 (KMT3C), ASH1L methylate methyl-lysine-37 of histone H3 (H3K36) IEA Dictyostelium discoideum DDB_G0267402 R-DDI-5638333 https://reactome.org/PathwayBrowser/#/R-DDI-5638333 WHSC1 (KMT3G) methylates lysine-28 of histone H3 (H3K27) IEA Dictyostelium discoideum DDB_G0267402 R-DDI-5649764 https://reactome.org/PathwayBrowser/#/R-DDI-5649764 DOT1L (KMT4) methylates methyl-lysine-80 of histone H3 (H3K79) IEA Dictyostelium discoideum DDB_G0267402 R-DDI-5649799 https://reactome.org/PathwayBrowser/#/R-DDI-5649799 DOT1L (KMT4) methylates dimethyl-lysine-80 of histone H3 (H3K79) IEA Dictyostelium discoideum DDB_G0267402 R-DDI-5649800 https://reactome.org/PathwayBrowser/#/R-DDI-5649800 WHSC1L1 (KMT3F) methylates methyl-lysine-28 of histone H3 (H3K27) IEA Dictyostelium discoideum DDB_G0267402 R-DDI-5649801 https://reactome.org/PathwayBrowser/#/R-DDI-5649801 DOT1L (KMT4) methylates lysine-80 of histone H3 (H3K79) IEA Dictyostelium discoideum DDB_G0267402 R-DDI-5649802 https://reactome.org/PathwayBrowser/#/R-DDI-5649802 WHSC1L1 (KMT3F) methylates dimethyl-lysine-28 of histone H3 (H3K27) IEA Dictyostelium discoideum DDB_G0267402 R-DDI-5661116 https://reactome.org/PathwayBrowser/#/R-DDI-5661116 KDM5A-D demethylate Me3K5-histone H3 IEA Dictyostelium discoideum DDB_G0267402 R-DDI-5661117 https://reactome.org/PathwayBrowser/#/R-DDI-5661117 CCND1:CDK4:PRMT5:pT5-WDR77 methylates methyl-arginine-9 of histone H3 IEA Dictyostelium discoideum DDB_G0267402 R-DDI-5661121 https://reactome.org/PathwayBrowser/#/R-DDI-5661121 KDM6A, KDM6B, KDM7A demethylate Me3K28-histone H3 IEA Dictyostelium discoideum DDB_G0267402 R-DDI-5682588 https://reactome.org/PathwayBrowser/#/R-DDI-5682588 RNF8 binds phosphorylated MDC1 at DNA DSBs IEA Dictyostelium discoideum DDB_G0267402 R-DDI-5682965 https://reactome.org/PathwayBrowser/#/R-DDI-5682965 WHSC1 dimethylates histone H4 on lysine K21 at DSBs IEA Dictyostelium discoideum DDB_G0267402 R-DDI-5682967 https://reactome.org/PathwayBrowser/#/R-DDI-5682967 WHSC1 binds DNA DSBs IEA Dictyostelium discoideum DDB_G0267402 R-DDI-5682983 https://reactome.org/PathwayBrowser/#/R-DDI-5682983 ATM phosphorylates WHSC1 IEA Dictyostelium discoideum DDB_G0267402 R-DDI-5683405 https://reactome.org/PathwayBrowser/#/R-DDI-5683405 PPP5C dephosphorylates TP53BP1 IEA Dictyostelium discoideum DDB_G0267402 R-DDI-5683425 https://reactome.org/PathwayBrowser/#/R-DDI-5683425 ATM phosphorylates TP53BP1 at DNA DSBs IEA Dictyostelium discoideum DDB_G0267402 R-DDI-5693536 https://reactome.org/PathwayBrowser/#/R-DDI-5693536 ATM phosphorylates MDC1 IEA Dictyostelium discoideum DDB_G0267402 R-DDI-5693549 https://reactome.org/PathwayBrowser/#/R-DDI-5693549 ATM phosphorylates histone H2AFX on S139 at DNA DSBs IEA Dictyostelium discoideum DDB_G0267402 R-DDI-5693566 https://reactome.org/PathwayBrowser/#/R-DDI-5693566 TP53BP1 associates with H4K20Me2 at DNA DSBs IEA Dictyostelium discoideum DDB_G0267402 R-DDI-5693602 https://reactome.org/PathwayBrowser/#/R-DDI-5693602 ATM recognizes H2AFX-Nucleosomes IEA Dictyostelium discoideum DDB_G0267402 R-DDI-74986 https://reactome.org/PathwayBrowser/#/R-DDI-74986 Elongation of pre-rRNA transcript IEA Dictyostelium discoideum DDB_G0267402 R-DDI-8865613 https://reactome.org/PathwayBrowser/#/R-DDI-8865613 BRWD1 binds AcK(9,14,18,79)-p(S10,T11)-histone H3 IEA Dictyostelium discoideum DDB_G0267402 R-DDI-9749197 https://reactome.org/PathwayBrowser/#/R-DDI-9749197 ORC1 binds to H4K20me2 IEA Dictyostelium discoideum DDB_G0267402 R-DDI-9843978 https://reactome.org/PathwayBrowser/#/R-DDI-9843978 CBX5 (HP-1alpha) binds TRIM28 (KAP1) in SUMO2-6K-TRIM28:KRAB-ZFP:retroelement chromatin IEA Dictyostelium discoideum DDB_G0267402 R-DDI-994106 https://reactome.org/PathwayBrowser/#/R-DDI-994106 HP1 alpha binds Histone H3K9(me)3 IEA Dictyostelium discoideum DDB_G0267406 R-DDI-434381 https://reactome.org/PathwayBrowser/#/R-DDI-434381 CD36 (FAT) translocates palmitate from the extracellular region to the cytosol IEA Dictyostelium discoideum DDB_G0267406 R-DDI-481044 https://reactome.org/PathwayBrowser/#/R-DDI-481044 Surface deployment of platelet alpha granule membrane components IEA Dictyostelium discoideum DDB_G0267406 R-DDI-6799350 https://reactome.org/PathwayBrowser/#/R-DDI-6799350 Exocytosis of specific granule membrane proteins IEA Dictyostelium discoideum DDB_G0267408 R-DDI-1236970 https://reactome.org/PathwayBrowser/#/R-DDI-1236970 Proteasomal clevage of exogenous antigen (26S proteasome catalyst) IEA Dictyostelium discoideum DDB_G0267408 R-DDI-1504193 https://reactome.org/PathwayBrowser/#/R-DDI-1504193 Ubiquitinated DVL is degraded by the proteasome IEA Dictyostelium discoideum DDB_G0267408 R-DDI-174058 https://reactome.org/PathwayBrowser/#/R-DDI-174058 Degradation of multiubiquitinated Cdh1 IEA Dictyostelium discoideum DDB_G0267408 R-DDI-174105 https://reactome.org/PathwayBrowser/#/R-DDI-174105 Degradation of multiubiquitinated cell cycle proteins IEA Dictyostelium discoideum DDB_G0267408 R-DDI-174202 https://reactome.org/PathwayBrowser/#/R-DDI-174202 Degradation of multiubiquitinated Securin IEA Dictyostelium discoideum DDB_G0267408 R-DDI-188191 https://reactome.org/PathwayBrowser/#/R-DDI-188191 APC/C:Cdh1-mediated degradation of Skp2 IEA Dictyostelium discoideum DDB_G0267408 R-DDI-264458 https://reactome.org/PathwayBrowser/#/R-DDI-264458 Proteasome mediated degradation of COP1 IEA Dictyostelium discoideum DDB_G0267408 R-DDI-450466 https://reactome.org/PathwayBrowser/#/R-DDI-450466 AUF1:mRNA complex is destroyed IEA Dictyostelium discoideum DDB_G0267408 R-DDI-5635854 https://reactome.org/PathwayBrowser/#/R-DDI-5635854 GLI2,3 are degraded by the proteasome IEA Dictyostelium discoideum DDB_G0267408 R-DDI-5658430 https://reactome.org/PathwayBrowser/#/R-DDI-5658430 NF1 is degraded by the proteasome IEA Dictyostelium discoideum DDB_G0267408 R-DDI-5665854 https://reactome.org/PathwayBrowser/#/R-DDI-5665854 ADRM1:26S proteaseome binds UCHL5 IEA Dictyostelium discoideum DDB_G0267408 R-DDI-5665871 https://reactome.org/PathwayBrowser/#/R-DDI-5665871 ADRM1 binds 26S proteasome IEA Dictyostelium discoideum DDB_G0267408 R-DDI-5687112 https://reactome.org/PathwayBrowser/#/R-DDI-5687112 MAPK6 is degraded by the 26S proteasome IEA Dictyostelium discoideum DDB_G0267408 R-DDI-5689539 https://reactome.org/PathwayBrowser/#/R-DDI-5689539 ADRM1:26S proteaseome binds USP14 IEA Dictyostelium discoideum DDB_G0267408 R-DDI-68948 https://reactome.org/PathwayBrowser/#/R-DDI-68948 Ubiquitinated Orc1 is degraded by the proteasome IEA Dictyostelium discoideum DDB_G0267408 R-DDI-69016 https://reactome.org/PathwayBrowser/#/R-DDI-69016 Ubiquitinated Cdc6 is degraded by the proteasome IEA Dictyostelium discoideum DDB_G0267408 R-DDI-69600 https://reactome.org/PathwayBrowser/#/R-DDI-69600 Proteolytic degradation of ubiquitinated-Cdc25A IEA Dictyostelium discoideum DDB_G0267408 R-DDI-8850992 https://reactome.org/PathwayBrowser/#/R-DDI-8850992 Proteasome degrades polyubiquitinated PTEN IEA Dictyostelium discoideum DDB_G0267408 R-DDI-8854044 https://reactome.org/PathwayBrowser/#/R-DDI-8854044 Proteasome degrades AURKA ubiquitinated by SCF-FBXL7 IEA Dictyostelium discoideum DDB_G0267408 R-DDI-8866553 https://reactome.org/PathwayBrowser/#/R-DDI-8866553 misfolded CFTR is degraded by the 26S proteasome IEA Dictyostelium discoideum DDB_G0267408 R-DDI-9755306 https://reactome.org/PathwayBrowser/#/R-DDI-9755306 ub UBXN7 is degraded by the 26S proteasome IEA Dictyostelium discoideum DDB_G0267408 R-DDI-983150 https://reactome.org/PathwayBrowser/#/R-DDI-983150 Proteasomal cleavage of substrate IEA Dictyostelium discoideum DDB_G0267408 R-DDI-9907912 https://reactome.org/PathwayBrowser/#/R-DDI-9907912 Formation of the outer ring of the 20S core particle IEA Dictyostelium discoideum DDB_G0267408 R-DDI-9907919 https://reactome.org/PathwayBrowser/#/R-DDI-9907919 Formation of the preholoproteasome IEA Dictyostelium discoideum DDB_G0267408 R-DDI-9907925 https://reactome.org/PathwayBrowser/#/R-DDI-9907925 Formation of the inner ring of the 20S immunoproteasome core particle IEA Dictyostelium discoideum DDB_G0267408 R-DDI-9907928 https://reactome.org/PathwayBrowser/#/R-DDI-9907928 Formation of the inner ring of the 20S thymoproteasome core particle IEA Dictyostelium discoideum DDB_G0267408 R-DDI-9907940 https://reactome.org/PathwayBrowser/#/R-DDI-9907940 Formation of the preholothymoproteasome IEA Dictyostelium discoideum DDB_G0267408 R-DDI-9907941 https://reactome.org/PathwayBrowser/#/R-DDI-9907941 Fromation of the preholoimmunoproteasome IEA Dictyostelium discoideum DDB_G0267408 R-DDI-9908052 https://reactome.org/PathwayBrowser/#/R-DDI-9908052 PSMG1:PSMG2 dimer binds the 20S core particle outer ring IEA Dictyostelium discoideum DDB_G0267408 R-DDI-9908069 https://reactome.org/PathwayBrowser/#/R-DDI-9908069 POMP binds the 20S core particle outer ring IEA Dictyostelium discoideum DDB_G0267408 R-DDI-9908178 https://reactome.org/PathwayBrowser/#/R-DDI-9908178 Formation of the 26S proteasome IEA Dictyostelium discoideum DDB_G0267408 R-DDI-9908709 https://reactome.org/PathwayBrowser/#/R-DDI-9908709 Formation of the PA28-alpha-beta-20S proteasome IEA Dictyostelium discoideum DDB_G0267408 R-DDI-9908721 https://reactome.org/PathwayBrowser/#/R-DDI-9908721 Formation of the PA28gamma-20S proteasome IEA Dictyostelium discoideum DDB_G0267414 R-DDI-109639 https://reactome.org/PathwayBrowser/#/R-DDI-109639 Formation of the closed pre-initiation complex IEA Dictyostelium discoideum DDB_G0267414 R-DDI-111264 https://reactome.org/PathwayBrowser/#/R-DDI-111264 Addition of nucleotides between position +11 and +30 IEA Dictyostelium discoideum DDB_G0267414 R-DDI-112383 https://reactome.org/PathwayBrowser/#/R-DDI-112383 Hypophosphorylation of RNA Pol II CTD by FCP1P protein IEA Dictyostelium discoideum DDB_G0267414 R-DDI-113430 https://reactome.org/PathwayBrowser/#/R-DDI-113430 Extrusion of 5'-end of 30 nt long transcript through the pore in Pol II complex IEA Dictyostelium discoideum DDB_G0267414 R-DDI-5690996 https://reactome.org/PathwayBrowser/#/R-DDI-5690996 ERCC2 and ERCC3 DNA helicases form an open bubble structure in damaged DNA IEA Dictyostelium discoideum DDB_G0267414 R-DDI-5691000 https://reactome.org/PathwayBrowser/#/R-DDI-5691000 TFIIH binds GG-NER site to form a verification complex IEA Dictyostelium discoideum DDB_G0267414 R-DDI-6781818 https://reactome.org/PathwayBrowser/#/R-DDI-6781818 RNA Pol II initiates transcription from damaged DNA template IEA Dictyostelium discoideum DDB_G0267414 R-DDI-6781824 https://reactome.org/PathwayBrowser/#/R-DDI-6781824 Active RNA Pol II complex transcribes lesion-containing DNA template IEA Dictyostelium discoideum DDB_G0267414 R-DDI-6781833 https://reactome.org/PathwayBrowser/#/R-DDI-6781833 ERCC8 (CSA) binds stalled RNA Pol II IEA Dictyostelium discoideum DDB_G0267414 R-DDI-6781840 https://reactome.org/PathwayBrowser/#/R-DDI-6781840 ERCC6 binds stalled RNA Pol II IEA Dictyostelium discoideum DDB_G0267414 R-DDI-6781867 https://reactome.org/PathwayBrowser/#/R-DDI-6781867 ERCC8:DDB1:CUL4:RBX1 ubiquitinates ERCC6 and RNA Pol II IEA Dictyostelium discoideum DDB_G0267414 R-DDI-6782069 https://reactome.org/PathwayBrowser/#/R-DDI-6782069 UVSSA:USP7 deubiquitinates ERCC6 IEA Dictyostelium discoideum DDB_G0267414 R-DDI-6782131 https://reactome.org/PathwayBrowser/#/R-DDI-6782131 ERCC2-facilitated RNA Pol II backtracking in TC-NER IEA Dictyostelium discoideum DDB_G0267414 R-DDI-6782141 https://reactome.org/PathwayBrowser/#/R-DDI-6782141 Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in TC-NER IEA Dictyostelium discoideum DDB_G0267414 R-DDI-6782204 https://reactome.org/PathwayBrowser/#/R-DDI-6782204 5' incision of damaged DNA strand by ERCC1:ERCC4 in TC-NER IEA Dictyostelium discoideum DDB_G0267414 R-DDI-6782208 https://reactome.org/PathwayBrowser/#/R-DDI-6782208 Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in TC-NER IEA Dictyostelium discoideum DDB_G0267414 R-DDI-6782211 https://reactome.org/PathwayBrowser/#/R-DDI-6782211 DNA polymerases delta, epsilon or kappa bind the TC-NER site IEA Dictyostelium discoideum DDB_G0267414 R-DDI-6782227 https://reactome.org/PathwayBrowser/#/R-DDI-6782227 Ligation of newly synthesized repair patch to incised DNA in TC-NER IEA Dictyostelium discoideum DDB_G0267414 R-DDI-6797606 https://reactome.org/PathwayBrowser/#/R-DDI-6797606 CDK12 phosphorylates RNA Pol II CTD at DNA repair genes IEA Dictyostelium discoideum DDB_G0267414 R-DDI-6797616 https://reactome.org/PathwayBrowser/#/R-DDI-6797616 CCNK:CDK12 binds RNA Pol II at DNA repair genes IEA Dictyostelium discoideum DDB_G0267414 R-DDI-73769 https://reactome.org/PathwayBrowser/#/R-DDI-73769 Loss of Rrn3 from RNA Polymerase I promoter escape complex IEA Dictyostelium discoideum DDB_G0267414 R-DDI-73946 https://reactome.org/PathwayBrowser/#/R-DDI-73946 Abortive initiation after formation of the first phosphodiester bond IEA Dictyostelium discoideum DDB_G0267414 R-DDI-74986 https://reactome.org/PathwayBrowser/#/R-DDI-74986 Elongation of pre-rRNA transcript IEA Dictyostelium discoideum DDB_G0267414 R-DDI-75850 https://reactome.org/PathwayBrowser/#/R-DDI-75850 Addition of the third nucleotide on the nascent transcript IEA Dictyostelium discoideum DDB_G0267414 R-DDI-75856 https://reactome.org/PathwayBrowser/#/R-DDI-75856 Abortive Initiation Before Second Transition IEA Dictyostelium discoideum DDB_G0267414 R-DDI-75861 https://reactome.org/PathwayBrowser/#/R-DDI-75861 NTP Binds Active Site of RNA Polymerase II IEA Dictyostelium discoideum DDB_G0267414 R-DDI-75862 https://reactome.org/PathwayBrowser/#/R-DDI-75862 Fall Back to Closed Pre-initiation Complex IEA Dictyostelium discoideum DDB_G0267414 R-DDI-75864 https://reactome.org/PathwayBrowser/#/R-DDI-75864 Newly Formed Phosphodiester Bond Stabilized and PPi Released IEA Dictyostelium discoideum DDB_G0267414 R-DDI-75866 https://reactome.org/PathwayBrowser/#/R-DDI-75866 Nucleophillic Attack by 3'-hydroxyl Oxygen of nascent transcript on the Alpha Phosphate of NTP IEA Dictyostelium discoideum DDB_G0267414 R-DDI-75869 https://reactome.org/PathwayBrowser/#/R-DDI-75869 Addition of the fourth nucleotide on the Nascent Transcript: Second Transition IEA Dictyostelium discoideum DDB_G0267414 R-DDI-75873 https://reactome.org/PathwayBrowser/#/R-DDI-75873 Addition of Nucleotides 5 through 9 on the growing Transcript IEA Dictyostelium discoideum DDB_G0267414 R-DDI-75891 https://reactome.org/PathwayBrowser/#/R-DDI-75891 Abortive Initiation After Second Transition IEA Dictyostelium discoideum DDB_G0267414 R-DDI-75949 https://reactome.org/PathwayBrowser/#/R-DDI-75949 RNA Polymerase II Promoter Opening: First Transition IEA Dictyostelium discoideum DDB_G0267414 R-DDI-76576 https://reactome.org/PathwayBrowser/#/R-DDI-76576 Addition of nucleotides 10 and 11 on the growing transcript: Third Transition IEA Dictyostelium discoideum DDB_G0267414 R-DDI-77068 https://reactome.org/PathwayBrowser/#/R-DDI-77068 Activation of GT IEA Dictyostelium discoideum DDB_G0267414 R-DDI-77069 https://reactome.org/PathwayBrowser/#/R-DDI-77069 RNA Polymerase II CTD (phosphorylated) binds to CE IEA Dictyostelium discoideum DDB_G0267414 R-DDI-77071 https://reactome.org/PathwayBrowser/#/R-DDI-77071 Phosphorylation (Ser5) of RNA pol II CTD IEA Dictyostelium discoideum DDB_G0267414 R-DDI-77073 https://reactome.org/PathwayBrowser/#/R-DDI-77073 SPT5 subunit of Pol II binds the RNA triphosphatase (RTP) IEA Dictyostelium discoideum DDB_G0267414 R-DDI-77077 https://reactome.org/PathwayBrowser/#/R-DDI-77077 Capping complex formation IEA Dictyostelium discoideum DDB_G0267414 R-DDI-77078 https://reactome.org/PathwayBrowser/#/R-DDI-77078 Hydrolysis of the 5'-end of the nascent transcript by the capping enzyme IEA Dictyostelium discoideum DDB_G0267414 R-DDI-77081 https://reactome.org/PathwayBrowser/#/R-DDI-77081 Formation of the CE:GMP intermediate complex IEA Dictyostelium discoideum DDB_G0267414 R-DDI-77083 https://reactome.org/PathwayBrowser/#/R-DDI-77083 Transfer of GMP from the capping enzyme GT site to 5'-end of mRNA IEA Dictyostelium discoideum DDB_G0267414 R-DDI-77085 https://reactome.org/PathwayBrowser/#/R-DDI-77085 Dissociation of transcript with 5'-GMP from GT IEA Dictyostelium discoideum DDB_G0267414 R-DDI-77090 https://reactome.org/PathwayBrowser/#/R-DDI-77090 Methylation of GMP-cap by RNA Methyltransferase IEA Dictyostelium discoideum DDB_G0267414 R-DDI-9613494 https://reactome.org/PathwayBrowser/#/R-DDI-9613494 Unwinding of DNA for the Nascent Transcript: Second Transition IEA Dictyostelium discoideum DDB_G0267414 R-DDI-9613497 https://reactome.org/PathwayBrowser/#/R-DDI-9613497 Unwinding DNA for the nascent transcript IEA Dictyostelium discoideum DDB_G0267414 R-DDI-9684118 https://reactome.org/PathwayBrowser/#/R-DDI-9684118 ERCC3-facilitated RNA Pol II backtracking in TC-NER IEA Dictyostelium discoideum DDB_G0267416 R-DDI-163296 https://reactome.org/PathwayBrowser/#/R-DDI-163296 Association of TFAM:mt promoter complex with POLRMT:TFB2M IEA Dictyostelium discoideum DDB_G0267418 R-DDI-174401 https://reactome.org/PathwayBrowser/#/R-DDI-174401 AHCY:NAD+ tetramer hydrolyses AdoHcy IEA Dictyostelium discoideum DDB_G0267436 R-DDI-5227009 https://reactome.org/PathwayBrowser/#/R-DDI-5227009 ABCF1 binds EIF2 IEA Dictyostelium discoideum DDB_G0267438 R-DDI-1369028 https://reactome.org/PathwayBrowser/#/R-DDI-1369028 ABCAs mediate lipid efflux IEA Dictyostelium discoideum DDB_G0267438 R-DDI-1369052 https://reactome.org/PathwayBrowser/#/R-DDI-1369052 ABCAs mediate lipid influx IEA Dictyostelium discoideum DDB_G0267438 R-DDI-1467457 https://reactome.org/PathwayBrowser/#/R-DDI-1467457 ABCA8,B1,B5 transport xenobiotics from cytosol to extracellular region IEA Dictyostelium discoideum DDB_G0267438 R-DDI-1467466 https://reactome.org/PathwayBrowser/#/R-DDI-1467466 ABCA4 mediates atRAL transport IEA Dictyostelium discoideum DDB_G0267438 R-DDI-5682103 https://reactome.org/PathwayBrowser/#/R-DDI-5682103 4xPALM-C-ABCA1 tetramer translocates from ER membrane to plasma membrane IEA Dictyostelium discoideum DDB_G0267438 R-DDI-5682285 https://reactome.org/PathwayBrowser/#/R-DDI-5682285 ABCA12 transports lipids from cytosol to extracellular region IEA Dictyostelium discoideum DDB_G0267438 R-DDI-5683714 https://reactome.org/PathwayBrowser/#/R-DDI-5683714 ABCA3 transports PC, PG from ER membrane to lamellar body IEA Dictyostelium discoideum DDB_G0267438 R-DDI-6798739 https://reactome.org/PathwayBrowser/#/R-DDI-6798739 Exocytosis of azurophil granule membrane proteins IEA Dictyostelium discoideum DDB_G0267438 R-DDI-6798743 https://reactome.org/PathwayBrowser/#/R-DDI-6798743 Exocytosis of secretory granule membrane proteins IEA Dictyostelium discoideum DDB_G0267440 R-DDI-434381 https://reactome.org/PathwayBrowser/#/R-DDI-434381 CD36 (FAT) translocates palmitate from the extracellular region to the cytosol IEA Dictyostelium discoideum DDB_G0267440 R-DDI-481044 https://reactome.org/PathwayBrowser/#/R-DDI-481044 Surface deployment of platelet alpha granule membrane components IEA Dictyostelium discoideum DDB_G0267440 R-DDI-6799350 https://reactome.org/PathwayBrowser/#/R-DDI-6799350 Exocytosis of specific granule membrane proteins IEA Dictyostelium discoideum DDB_G0267440 R-DDI-8866277 https://reactome.org/PathwayBrowser/#/R-DDI-8866277 AP-2 directly binds some endocytic cargo IEA Dictyostelium discoideum DDB_G0267440 R-DDI-8868072 https://reactome.org/PathwayBrowser/#/R-DDI-8868072 Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2 IEA Dictyostelium discoideum DDB_G0267446 R-DDI-2730867 https://reactome.org/PathwayBrowser/#/R-DDI-2730867 Translocation of CaN:CaM:NFAT to nucleus IEA Dictyostelium discoideum DDB_G0267446 R-DDI-2730872 https://reactome.org/PathwayBrowser/#/R-DDI-2730872 Activation of Calcineurin IEA Dictyostelium discoideum DDB_G0267446 R-DDI-4551465 https://reactome.org/PathwayBrowser/#/R-DDI-4551465 Translocation of NFATC1:CaN:CaM to nucleus IEA Dictyostelium discoideum DDB_G0267450 R-DDI-2029454 https://reactome.org/PathwayBrowser/#/R-DDI-2029454 Autophosphorylation of PAK1 IEA Dictyostelium discoideum DDB_G0267450 R-DDI-2029456 https://reactome.org/PathwayBrowser/#/R-DDI-2029456 RAC1 and CDC42 activate PAK1 IEA Dictyostelium discoideum DDB_G0267450 R-DDI-2029460 https://reactome.org/PathwayBrowser/#/R-DDI-2029460 PAK1 phosphorylates LIMK1 IEA Dictyostelium discoideum DDB_G0267450 R-DDI-389788 https://reactome.org/PathwayBrowser/#/R-DDI-389788 Activation of PAKs by RAC1 and CDC42 IEA Dictyostelium discoideum DDB_G0267450 R-DDI-3928619 https://reactome.org/PathwayBrowser/#/R-DDI-3928619 PAK1 binds RAC1:GTP IEA Dictyostelium discoideum DDB_G0267450 R-DDI-3928620 https://reactome.org/PathwayBrowser/#/R-DDI-3928620 PAK1 autophosphorylates IEA Dictyostelium discoideum DDB_G0267450 R-DDI-445072 https://reactome.org/PathwayBrowser/#/R-DDI-445072 Interaction of PAK1 with Rac1-GTP IEA Dictyostelium discoideum DDB_G0267450 R-DDI-5627775 https://reactome.org/PathwayBrowser/#/R-DDI-5627775 Autophosphorylation of PAK1,2,3 IEA Dictyostelium discoideum DDB_G0267450 R-DDI-5668932 https://reactome.org/PathwayBrowser/#/R-DDI-5668932 PAK2 phosphorylates myosin regulatory light chain (MRLC) IEA Dictyostelium discoideum DDB_G0267450 R-DDI-5669240 https://reactome.org/PathwayBrowser/#/R-DDI-5669240 FLNA binds PAK1 IEA Dictyostelium discoideum DDB_G0267450 R-DDI-5669250 https://reactome.org/PathwayBrowser/#/R-DDI-5669250 PAK1 phosphorylates FLNA IEA Dictyostelium discoideum DDB_G0267450 R-DDI-5687086 https://reactome.org/PathwayBrowser/#/R-DDI-5687086 PAK1,2,3 phosphorylates MAPK6,4 IEA Dictyostelium discoideum DDB_G0267450 R-DDI-8981926 https://reactome.org/PathwayBrowser/#/R-DDI-8981926 RAC1 and CDC42 activate PAK3 IEA Dictyostelium discoideum DDB_G0267450 R-DDI-8981931 https://reactome.org/PathwayBrowser/#/R-DDI-8981931 RAC1 and CDC42 activate PAK2 IEA Dictyostelium discoideum DDB_G0267450 R-DDI-9013145 https://reactome.org/PathwayBrowser/#/R-DDI-9013145 RAC1 binds effectors at the plasma membrane IEA Dictyostelium discoideum DDB_G0267450 R-DDI-9014294 https://reactome.org/PathwayBrowser/#/R-DDI-9014294 RAC2 binds effectors at the plasma membrane IEA Dictyostelium discoideum DDB_G0267450 R-DDI-9014449 https://reactome.org/PathwayBrowser/#/R-DDI-9014449 RHOG binds effectors at the plasma membrane IEA Dictyostelium discoideum DDB_G0267450 R-DDI-9018746 https://reactome.org/PathwayBrowser/#/R-DDI-9018746 RHOQ binds effectors at the plasma membrane IEA Dictyostelium discoideum DDB_G0267450 R-DDI-9018758 https://reactome.org/PathwayBrowser/#/R-DDI-9018758 RHOH binds effectors at the plasma membrane IEA Dictyostelium discoideum DDB_G0267450 R-DDI-9018766 https://reactome.org/PathwayBrowser/#/R-DDI-9018766 RHOU binds effectors at the plasma membrane IEA Dictyostelium discoideum DDB_G0267450 R-DDI-9018794 https://reactome.org/PathwayBrowser/#/R-DDI-9018794 RHOV binds effectors at the plasma membrane IEA Dictyostelium discoideum DDB_G0267450 R-DDI-9018808 https://reactome.org/PathwayBrowser/#/R-DDI-9018808 RAC3 binds effectors at the plasma membrane IEA Dictyostelium discoideum DDB_G0267452 R-DDI-8866275 https://reactome.org/PathwayBrowser/#/R-DDI-8866275 UBQLNs bind UIM-containing adaptor proteins IEA Dictyostelium discoideum DDB_G0267454 R-DDI-163215 https://reactome.org/PathwayBrowser/#/R-DDI-163215 SLC25A5,6 dimers exchange ATP for ADP across the mitochondrial inner membrane IEA Dictyostelium discoideum DDB_G0267454 R-DDI-1955380 https://reactome.org/PathwayBrowser/#/R-DDI-1955380 TIMM9:TIMM10 transfers proteins to TIMM22 IEA Dictyostelium discoideum DDB_G0267454 R-DDI-9837978 https://reactome.org/PathwayBrowser/#/R-DDI-9837978 LONP1 binds mitochondrial inner membrane proteins IEA Dictyostelium discoideum DDB_G0267454 R-DDI-9838004 https://reactome.org/PathwayBrowser/#/R-DDI-9838004 LONP1 degrades mitochondrial inner membrane proteins IEA Dictyostelium discoideum DDB_G0267454 R-DDI-9864415 https://reactome.org/PathwayBrowser/#/R-DDI-9864415 AAC1 imports a proton IEA Dictyostelium discoideum DDB_G0267462 R-DDI-1675824 https://reactome.org/PathwayBrowser/#/R-DDI-1675824 PI(4,5)P2 is dephosphorylated to PI4P by OCRL/INPP5E at the Golgi membrane IEA Dictyostelium discoideum DDB_G0267462 R-DDI-1675836 https://reactome.org/PathwayBrowser/#/R-DDI-1675836 PI(3,5)P2 is dephosphorylated to PI3P by SYNJ at the plasma membrane IEA Dictyostelium discoideum DDB_G0267462 R-DDI-1675988 https://reactome.org/PathwayBrowser/#/R-DDI-1675988 PI4P is dephosphorylated to PI by SYNJ at the plasma membrane IEA Dictyostelium discoideum DDB_G0267462 R-DDI-1855174 https://reactome.org/PathwayBrowser/#/R-DDI-1855174 I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5(4) in the cytosol IEA Dictyostelium discoideum DDB_G0267462 R-DDI-1855213 https://reactome.org/PathwayBrowser/#/R-DDI-1855213 I(1,3,4,5)P4 is dephosphorylated to I(1,3,4)P3 by INPP5B at the plasma membrane IEA Dictyostelium discoideum DDB_G0267462 R-DDI-1855218 https://reactome.org/PathwayBrowser/#/R-DDI-1855218 I(1,3,4,5)P4 is dephosphorylated to I(1,3,4)P3 by INPP5[3]/ITPK1 in the cytosol IEA Dictyostelium discoideum DDB_G0267462 R-DDI-1855222 https://reactome.org/PathwayBrowser/#/R-DDI-1855222 I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5A/B at the plasma membrane IEA Dictyostelium discoideum DDB_G0267462 R-DDI-9017488 https://reactome.org/PathwayBrowser/#/R-DDI-9017488 RHOJ GAPs stimulate RHOJ GTPase activity IEA Dictyostelium discoideum DDB_G0267462 R-DDI-9018806 https://reactome.org/PathwayBrowser/#/R-DDI-9018806 RAC3 GAPs stimulate RAC3 GTPase activity IEA Dictyostelium discoideum DDB_G0267468 R-DDI-5649873 https://reactome.org/PathwayBrowser/#/R-DDI-5649873 PARP1,PARP2 dimers and FEN1 bind POLB and displace APEX1 from damaged AP site IEA Dictyostelium discoideum DDB_G0267468 R-DDI-5649883 https://reactome.org/PathwayBrowser/#/R-DDI-5649883 POLB-mediated DNA strand displacement synthesis IEA Dictyostelium discoideum DDB_G0267468 R-DDI-5651723 https://reactome.org/PathwayBrowser/#/R-DDI-5651723 PARP1,PARP2 dimers bound to FEN1 and POLB autoPARylate IEA Dictyostelium discoideum DDB_G0267468 R-DDI-5651739 https://reactome.org/PathwayBrowser/#/R-DDI-5651739 PAR-PARP1,PAR-PARP2 dissociate from FEN1 and POLB IEA Dictyostelium discoideum DDB_G0267468 R-DDI-5651828 https://reactome.org/PathwayBrowser/#/R-DDI-5651828 PARG dePARylates PARP1,PARP2 IEA Dictyostelium discoideum DDB_G0267468 R-DDI-5690996 https://reactome.org/PathwayBrowser/#/R-DDI-5690996 ERCC2 and ERCC3 DNA helicases form an open bubble structure in damaged DNA IEA Dictyostelium discoideum DDB_G0267468 R-DDI-5691000 https://reactome.org/PathwayBrowser/#/R-DDI-5691000 TFIIH binds GG-NER site to form a verification complex IEA Dictyostelium discoideum DDB_G0267468 R-DDI-5696655 https://reactome.org/PathwayBrowser/#/R-DDI-5696655 PARP1 or PARP2 PARylates DDB2 and autoPARylates IEA Dictyostelium discoideum DDB_G0267468 R-DDI-5696664 https://reactome.org/PathwayBrowser/#/R-DDI-5696664 PARP1 or PARP2 binds DDB2 at GG-NER site IEA Dictyostelium discoideum DDB_G0267472 R-DDI-9793472 https://reactome.org/PathwayBrowser/#/R-DDI-9793472 RIPK3 binds p-S9-PRKN IEA Dictyostelium discoideum DDB_G0267472 R-DDI-9793485 https://reactome.org/PathwayBrowser/#/R-DDI-9793485 PRKN polyubiquitinates RIPK3 IEA Dictyostelium discoideum DDB_G0267486 R-DDI-1362408 https://reactome.org/PathwayBrowser/#/R-DDI-1362408 FXN:NFS1:ISD11:ISCU assembles 2Fe-2S iron-sulfur cluster IEA Dictyostelium discoideum DDB_G0267486 R-DDI-2395512 https://reactome.org/PathwayBrowser/#/R-DDI-2395512 FDXR transfers electrons to FDX1,2 (FDX1L) IEA Dictyostelium discoideum DDB_G0267490 R-DDI-430347 https://reactome.org/PathwayBrowser/#/R-DDI-430347 MigFilin associates with Filamin and F-actin IEA Dictyostelium discoideum DDB_G0267490 R-DDI-446364 https://reactome.org/PathwayBrowser/#/R-DDI-446364 Migfilin interacts with VASP IEA Dictyostelium discoideum DDB_G0267492 R-DDI-9840564 https://reactome.org/PathwayBrowser/#/R-DDI-9840564 OMA1 hydrolyzes YME1L1 IEA Dictyostelium discoideum DDB_G0267514 R-DDI-9793472 https://reactome.org/PathwayBrowser/#/R-DDI-9793472 RIPK3 binds p-S9-PRKN IEA Dictyostelium discoideum DDB_G0267514 R-DDI-9793485 https://reactome.org/PathwayBrowser/#/R-DDI-9793485 PRKN polyubiquitinates RIPK3 IEA Dictyostelium discoideum DDB_G0267536 R-DDI-70881 https://reactome.org/PathwayBrowser/#/R-DDI-70881 beta-hydroxyisobutyryl-CoA + H2O => beta-hydroxyisobutyrate + CoA IEA Dictyostelium discoideum DDB_G0267546 R-DDI-196761 https://reactome.org/PathwayBrowser/#/R-DDI-196761 2xTPK1:Mg2+ phosphorylates THMN IEA Dictyostelium discoideum DDB_G0267548 R-DDI-8848618 https://reactome.org/PathwayBrowser/#/R-DDI-8848618 Activation of RAC1 by the PXN:CRK complex IEA Dictyostelium discoideum DDB_G0267548 R-DDI-9014449 https://reactome.org/PathwayBrowser/#/R-DDI-9014449 RHOG binds effectors at the plasma membrane IEA Dictyostelium discoideum DDB_G0267566 R-DDI-5672948 https://reactome.org/PathwayBrowser/#/R-DDI-5672948 MARK3 phosphorylates KSR1 IEA Dictyostelium discoideum DDB_G0267566 R-DDI-5674019 https://reactome.org/PathwayBrowser/#/R-DDI-5674019 BRAP binds KSR1:MARK3 IEA Dictyostelium discoideum DDB_G0267588 R-DDI-1675773 https://reactome.org/PathwayBrowser/#/R-DDI-1675773 PI(3,4)P2 is phosphorylated to PI(3,4,5)P3 by PIP5K1A-C at the plasma membrane IEA Dictyostelium discoideum DDB_G0267588 R-DDI-1675776 https://reactome.org/PathwayBrowser/#/R-DDI-1675776 PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers at the plasma membrane IEA Dictyostelium discoideum DDB_G0267588 R-DDI-1675810 https://reactome.org/PathwayBrowser/#/R-DDI-1675810 PI is phosphorylated to PI5P by PIP5K1A/B at the plasma membrane IEA Dictyostelium discoideum DDB_G0267588 R-DDI-1676082 https://reactome.org/PathwayBrowser/#/R-DDI-1676082 PI4P is phosphorylated to PI(4,5)P2 by PIP5K1A-C at the plasma membrane IEA Dictyostelium discoideum DDB_G0267588 R-DDI-1676134 https://reactome.org/PathwayBrowser/#/R-DDI-1676134 PI3P is phosphorylated to PI(3,5)P2 by PIP5K1A/B at the plasma membrane IEA Dictyostelium discoideum DDB_G0267588 R-DDI-1676145 https://reactome.org/PathwayBrowser/#/R-DDI-1676145 PI3P is phosphorylated to PI(3,4)P2 by PIP4K2/5K1 at the plasma membrane IEA Dictyostelium discoideum DDB_G0267588 R-DDI-6811522 https://reactome.org/PathwayBrowser/#/R-DDI-6811522 PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers in the nucleus IEA Dictyostelium discoideum DDB_G0267588 R-DDI-8868066 https://reactome.org/PathwayBrowser/#/R-DDI-8868066 PIP5K1C phosphorylates PI(4)P to PI(4,5)P2 IEA Dictyostelium discoideum DDB_G0267588 R-DDI-8877691 https://reactome.org/PathwayBrowser/#/R-DDI-8877691 MAP2K6 phosphorylates PIP4K2B IEA Dictyostelium discoideum DDB_G0267588 R-DDI-8877692 https://reactome.org/PathwayBrowser/#/R-DDI-8877692 PIN1 binds phosphorylated PIP4K2B IEA Dictyostelium discoideum DDB_G0267590 R-DDI-376357 https://reactome.org/PathwayBrowser/#/R-DDI-376357 Vamp7 associated Lysosome to Plasma membrane transport IEA Dictyostelium discoideum DDB_G0267590 R-DDI-376364 https://reactome.org/PathwayBrowser/#/R-DDI-376364 Vamp8 associated secretory vesicle to plasma membrane transport IEA Dictyostelium discoideum DDB_G0267590 R-DDI-376369 https://reactome.org/PathwayBrowser/#/R-DDI-376369 Vamp2 associated secretory vesicle to plasma membrane transport IEA Dictyostelium discoideum DDB_G0267590 R-DDI-449117 https://reactome.org/PathwayBrowser/#/R-DDI-449117 TXLNA (IL14) binds syntaxin1A IEA Dictyostelium discoideum DDB_G0267590 R-DDI-6798739 https://reactome.org/PathwayBrowser/#/R-DDI-6798739 Exocytosis of azurophil granule membrane proteins IEA Dictyostelium discoideum DDB_G0267590 R-DDI-6798747 https://reactome.org/PathwayBrowser/#/R-DDI-6798747 Exocytosis of tertiary granule membrane proteins IEA Dictyostelium discoideum DDB_G0267590 R-DDI-6799350 https://reactome.org/PathwayBrowser/#/R-DDI-6799350 Exocytosis of specific granule membrane proteins IEA Dictyostelium discoideum DDB_G0267590 R-DDI-6811433 https://reactome.org/PathwayBrowser/#/R-DDI-6811433 The COG tethering complex interacts with numerous SNAREs at the Golgi membrane IEA Dictyostelium discoideum DDB_G0267590 R-DDI-9013145 https://reactome.org/PathwayBrowser/#/R-DDI-9013145 RAC1 binds effectors at the plasma membrane IEA Dictyostelium discoideum DDB_G0267590 R-DDI-9018746 https://reactome.org/PathwayBrowser/#/R-DDI-9018746 RHOQ binds effectors at the plasma membrane IEA Dictyostelium discoideum DDB_G0267590 R-DDI-9018808 https://reactome.org/PathwayBrowser/#/R-DDI-9018808 RAC3 binds effectors at the plasma membrane IEA Dictyostelium discoideum DDB_G0267606 R-DDI-6791222 https://reactome.org/PathwayBrowser/#/R-DDI-6791222 21S pre-rRNA is nucleolytically processed at site E (site2a) to yield 18SE pre-rRNA IEA Dictyostelium discoideum DDB_G0267606 R-DDI-6791227 https://reactome.org/PathwayBrowser/#/R-DDI-6791227 47S pre-rRNA is nucleolytically processed at A' (01,A1), site A0, and site 02 (site 6) to yield 45S pre-rRNA IEA Dictyostelium discoideum DDB_G0267622 R-DDI-1799332 https://reactome.org/PathwayBrowser/#/R-DDI-1799332 Nascent polypeptide:mRNA:ribosome complex binds signal recognition particle (SRP) IEA Dictyostelium discoideum DDB_G0267646 R-DDI-6811422 https://reactome.org/PathwayBrowser/#/R-DDI-6811422 NSF ATPase activity dissociates cis-SNARE at the ER IEA Dictyostelium discoideum DDB_G0267646 R-DDI-6811425 https://reactome.org/PathwayBrowser/#/R-DDI-6811425 NSF and SNAPs bind cis-SNARE at the ER membrane IEA Dictyostelium discoideum DDB_G0267646 R-DDI-6811427 https://reactome.org/PathwayBrowser/#/R-DDI-6811427 COPI vesicle uncoating at the ER IEA Dictyostelium discoideum DDB_G0267650 R-DDI-381091 https://reactome.org/PathwayBrowser/#/R-DDI-381091 IRE1 dimer autophosphorylates IEA Dictyostelium discoideum DDB_G0267650 R-DDI-381109 https://reactome.org/PathwayBrowser/#/R-DDI-381109 IRE1 binds IRE1 forming dimer IEA Dictyostelium discoideum DDB_G0267656 R-DDI-880050 https://reactome.org/PathwayBrowser/#/R-DDI-880050 (S)-2-hydroxyglutarate + FAD => 2-oxoglutarate + FADH2 IEA Dictyostelium discoideum DDB_G0267666 R-DDI-205039 https://reactome.org/PathwayBrowser/#/R-DDI-205039 p75NTR indirectly activates RAC and Cdc42 via a guanyl-nucleotide exchange factor IEA Dictyostelium discoideum DDB_G0267666 R-DDI-354173 https://reactome.org/PathwayBrowser/#/R-DDI-354173 Activation of Rap1 by cytosolic GEFs IEA Dictyostelium discoideum DDB_G0267666 R-DDI-381608 https://reactome.org/PathwayBrowser/#/R-DDI-381608 cAMP activates EPAC2 IEA Dictyostelium discoideum DDB_G0267666 R-DDI-381668 https://reactome.org/PathwayBrowser/#/R-DDI-381668 cAMP activates EPAC1 IEA Dictyostelium discoideum DDB_G0267666 R-DDI-381727 https://reactome.org/PathwayBrowser/#/R-DDI-381727 RAP1A exchanges GDP for GTP IEA Dictyostelium discoideum DDB_G0267666 R-DDI-392834 https://reactome.org/PathwayBrowser/#/R-DDI-392834 Activation of EPACs by cAMP IEA Dictyostelium discoideum DDB_G0267666 R-DDI-9013143 https://reactome.org/PathwayBrowser/#/R-DDI-9013143 RAC1 GEFs activate RAC1 IEA Dictyostelium discoideum DDB_G0267666 R-DDI-939265 https://reactome.org/PathwayBrowser/#/R-DDI-939265 Activation of Rap1 by membrane-associated GEFs IEA Dictyostelium discoideum DDB_G0267674 R-DDI-3322001 https://reactome.org/PathwayBrowser/#/R-DDI-3322001 GYS1 catalyzes the polyglucosylation of oligoGlc-GYG1 IEA Dictyostelium discoideum DDB_G0267674 R-DDI-3322003 https://reactome.org/PathwayBrowser/#/R-DDI-3322003 Autoglucosylation of GYG1 complexed with GYS1-b IEA Dictyostelium discoideum DDB_G0267674 R-DDI-3322005 https://reactome.org/PathwayBrowser/#/R-DDI-3322005 GBE1 catalyzes branch formation in polyGlc-GYG1 complexed with GYS1-a IEA Dictyostelium discoideum DDB_G0267674 R-DDI-3322009 https://reactome.org/PathwayBrowser/#/R-DDI-3322009 GYS2 catalyzes the polyglucosylation of oligoGlc-GYG2 IEA Dictyostelium discoideum DDB_G0267674 R-DDI-3322014 https://reactome.org/PathwayBrowser/#/R-DDI-3322014 Autoglucosylation of GYG2 complexed with GYS2-a IEA Dictyostelium discoideum DDB_G0267674 R-DDI-3322016 https://reactome.org/PathwayBrowser/#/R-DDI-3322016 GBE1 catalyzes branch formation in polyGlc-GYG2 complexed with GYS2-a IEA Dictyostelium discoideum DDB_G0267674 R-DDI-3322019 https://reactome.org/PathwayBrowser/#/R-DDI-3322019 Autoglucosylation of GYG2 complexed with GYS2-b IEA Dictyostelium discoideum DDB_G0267674 R-DDI-3322025 https://reactome.org/PathwayBrowser/#/R-DDI-3322025 Autoglucosylation of GYG1 complexed with GYS1-a IEA Dictyostelium discoideum DDB_G0267674 R-DDI-3322041 https://reactome.org/PathwayBrowser/#/R-DDI-3322041 Phosphorylated GYS1 catalyzes the polyglucosylation of oligoGlc-GYG1 IEA Dictyostelium discoideum DDB_G0267674 R-DDI-3322057 https://reactome.org/PathwayBrowser/#/R-DDI-3322057 GBE1 catalyzes branch formation in polyGlc-GYG1 complexed with GYS1-b IEA Dictyostelium discoideum DDB_G0267682 R-DDI-109955 https://reactome.org/PathwayBrowser/#/R-DDI-109955 Formation of ERCC1:XPF heterodimeric complex IEA Dictyostelium discoideum DDB_G0267682 R-DDI-6782141 https://reactome.org/PathwayBrowser/#/R-DDI-6782141 Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in TC-NER IEA Dictyostelium discoideum DDB_G0267682 R-DDI-6782204 https://reactome.org/PathwayBrowser/#/R-DDI-6782204 5' incision of damaged DNA strand by ERCC1:ERCC4 in TC-NER IEA Dictyostelium discoideum DDB_G0267682 R-DDI-6782211 https://reactome.org/PathwayBrowser/#/R-DDI-6782211 DNA polymerases delta, epsilon or kappa bind the TC-NER site IEA Dictyostelium discoideum DDB_G0267686 R-DDI-5672948 https://reactome.org/PathwayBrowser/#/R-DDI-5672948 MARK3 phosphorylates KSR1 IEA Dictyostelium discoideum DDB_G0267686 R-DDI-5674019 https://reactome.org/PathwayBrowser/#/R-DDI-5674019 BRAP binds KSR1:MARK3 IEA Dictyostelium discoideum DDB_G0267688 R-DDI-5333678 https://reactome.org/PathwayBrowser/#/R-DDI-5333678 CPNEs bind PL IEA Dictyostelium discoideum DDB_G0267688 R-DDI-6798739 https://reactome.org/PathwayBrowser/#/R-DDI-6798739 Exocytosis of azurophil granule membrane proteins IEA Dictyostelium discoideum DDB_G0267704 R-DDI-372480 https://reactome.org/PathwayBrowser/#/R-DDI-372480 2-oxoglutarate [mitochondrial matrix] + 2-oxoadipate [cytosol] <=> 2-oxoglutarate [cytosol] + 2-oxoadipate [mitochondrial matrix] IEA Dictyostelium discoideum DDB_G0267708 R-DDI-917696 https://reactome.org/PathwayBrowser/#/R-DDI-917696 Cargo Sequestration IEA Dictyostelium discoideum DDB_G0267708 R-DDI-917700 https://reactome.org/PathwayBrowser/#/R-DDI-917700 MVB Vesicle Formation IEA Dictyostelium discoideum DDB_G0267730 R-DDI-6799350 https://reactome.org/PathwayBrowser/#/R-DDI-6799350 Exocytosis of specific granule membrane proteins IEA Dictyostelium discoideum DDB_G0267742 R-DDI-5691512 https://reactome.org/PathwayBrowser/#/R-DDI-5691512 APEH hydrolyses NAc-Ser-protein IEA Dictyostelium discoideum DDB_G0267742 R-DDI-6800434 https://reactome.org/PathwayBrowser/#/R-DDI-6800434 Exocytosis of ficolin-rich granule lumen proteins IEA Dictyostelium discoideum DDB_G0267748 R-DDI-68914 https://reactome.org/PathwayBrowser/#/R-DDI-68914 DNA polymerase alpha:primase binds at the origin IEA Dictyostelium discoideum DDB_G0267748 R-DDI-68917 https://reactome.org/PathwayBrowser/#/R-DDI-68917 Cdc45 associates with the pre-replicative complex at the origin IEA Dictyostelium discoideum DDB_G0267748 R-DDI-68960 https://reactome.org/PathwayBrowser/#/R-DDI-68960 DNA polymerase epsilon binds at the origin IEA Dictyostelium discoideum DDB_G0267752 R-DDI-2684901 https://reactome.org/PathwayBrowser/#/R-DDI-2684901 ANOs transport cytosolic Cl- to extracellular region IEA Dictyostelium discoideum DDB_G0267752 R-DDI-6798747 https://reactome.org/PathwayBrowser/#/R-DDI-6798747 Exocytosis of tertiary granule membrane proteins IEA Dictyostelium discoideum DDB_G0267752 R-DDI-6799350 https://reactome.org/PathwayBrowser/#/R-DDI-6799350 Exocytosis of specific granule membrane proteins IEA Dictyostelium discoideum DDB_G0267752 R-DDI-9659568 https://reactome.org/PathwayBrowser/#/R-DDI-9659568 ANO1 transports cytosolic Cl- to extracellular region IEA Dictyostelium discoideum DDB_G0267752 R-DDI-9659611 https://reactome.org/PathwayBrowser/#/R-DDI-9659611 ANO1 inhibitors bind ANO1 IEA Dictyostelium discoideum DDB_G0267796 R-DDI-9770236 https://reactome.org/PathwayBrowser/#/R-DDI-9770236 Formation of the Spliceosomal P complex and exon ligation IEA Dictyostelium discoideum DDB_G0267830 R-DDI-9018814 https://reactome.org/PathwayBrowser/#/R-DDI-9018814 RHOT1 hydrolyzes GTP IEA Dictyostelium discoideum DDB_G0267830 R-DDI-9018815 https://reactome.org/PathwayBrowser/#/R-DDI-9018815 RHOT1 binds effectors at the mitochondrial outer membrane IEA Dictyostelium discoideum DDB_G0267830 R-DDI-9018824 https://reactome.org/PathwayBrowser/#/R-DDI-9018824 RHOT2 binds effectors at the mitochondrial outer membrane IEA Dictyostelium discoideum DDB_G0267830 R-DDI-9018826 https://reactome.org/PathwayBrowser/#/R-DDI-9018826 RHOT2 hydrolyzes GTP IEA Dictyostelium discoideum DDB_G0267866 R-DDI-9907919 https://reactome.org/PathwayBrowser/#/R-DDI-9907919 Formation of the preholoproteasome IEA Dictyostelium discoideum DDB_G0267866 R-DDI-9907925 https://reactome.org/PathwayBrowser/#/R-DDI-9907925 Formation of the inner ring of the 20S immunoproteasome core particle IEA Dictyostelium discoideum DDB_G0267866 R-DDI-9907928 https://reactome.org/PathwayBrowser/#/R-DDI-9907928 Formation of the inner ring of the 20S thymoproteasome core particle IEA Dictyostelium discoideum DDB_G0267866 R-DDI-9907940 https://reactome.org/PathwayBrowser/#/R-DDI-9907940 Formation of the preholothymoproteasome IEA Dictyostelium discoideum DDB_G0267866 R-DDI-9907941 https://reactome.org/PathwayBrowser/#/R-DDI-9907941 Fromation of the preholoimmunoproteasome IEA Dictyostelium discoideum DDB_G0267866 R-DDI-9908069 https://reactome.org/PathwayBrowser/#/R-DDI-9908069 POMP binds the 20S core particle outer ring IEA Dictyostelium discoideum DDB_G0267874 R-DDI-427998 https://reactome.org/PathwayBrowser/#/R-DDI-427998 SLC25A1 transports di-/tri-peptides and peptide-like drugs IEA Dictyostelium discoideum DDB_G0267884 R-DDI-446198 https://reactome.org/PathwayBrowser/#/R-DDI-446198 ALG12 transfers Man to N-glycan precursor (GlcNAc)2 (Man)7 (PP-Dol)1 IEA Dictyostelium discoideum DDB_G0267906 R-DDI-6807206 https://reactome.org/PathwayBrowser/#/R-DDI-6807206 USP13 and OTUD3 deubiquitinate PTEN IEA Dictyostelium discoideum DDB_G0267906 R-DDI-8873946 https://reactome.org/PathwayBrowser/#/R-DDI-8873946 OTUD3 deubiquitinates PTEN IEA Dictyostelium discoideum DDB_G0267950 R-DDI-6807872 https://reactome.org/PathwayBrowser/#/R-DDI-6807872 Active ARF recruits coatomer IEA Dictyostelium discoideum DDB_G0267950 R-DDI-6807875 https://reactome.org/PathwayBrowser/#/R-DDI-6807875 ARFGAP, cargo, v-SNAREs and p24 proteins bind nascent COPI complex IEA Dictyostelium discoideum DDB_G0267950 R-DDI-6807877 https://reactome.org/PathwayBrowser/#/R-DDI-6807877 ARFGAPs stimulate ARF GTPase activity IEA Dictyostelium discoideum DDB_G0267950 R-DDI-6809003 https://reactome.org/PathwayBrowser/#/R-DDI-6809003 ERGIC-to-Golgi vesicles bind dynein:dynactin IEA Dictyostelium discoideum DDB_G0267950 R-DDI-6809011 https://reactome.org/PathwayBrowser/#/R-DDI-6809011 cis-Golgi t-SNAREs bind YKT6 on tethered vesicle IEA Dictyostelium discoideum DDB_G0267950 R-DDI-6811412 https://reactome.org/PathwayBrowser/#/R-DDI-6811412 Active ARF recruits coatomer to the Golgi IEA Dictyostelium discoideum DDB_G0267950 R-DDI-6811417 https://reactome.org/PathwayBrowser/#/R-DDI-6811417 ARFGAP, cargo, vSNARES and p24 proteins bind COPI vesicles at Golgi IEA Dictyostelium discoideum DDB_G0267950 R-DDI-6811418 https://reactome.org/PathwayBrowser/#/R-DDI-6811418 ARFGAPs stimulate ARF GTPase activity at the Golgi membrane IEA Dictyostelium discoideum DDB_G0267950 R-DDI-6811427 https://reactome.org/PathwayBrowser/#/R-DDI-6811427 COPI vesicle uncoating at the ER IEA Dictyostelium discoideum DDB_G0267952 R-DDI-6798751 https://reactome.org/PathwayBrowser/#/R-DDI-6798751 Exocytosis of azurophil granule lumen proteins IEA Dictyostelium discoideum DDB_G0267956 R-DDI-2029466 https://reactome.org/PathwayBrowser/#/R-DDI-2029466 (WASPs, WAVE):G-actin:ARP2/3 binds F-actin IEA Dictyostelium discoideum DDB_G0267956 R-DDI-2029469 https://reactome.org/PathwayBrowser/#/R-DDI-2029469 p-ERK phosphorylates WAVEs and ABI IEA Dictyostelium discoideum DDB_G0267956 R-DDI-2197690 https://reactome.org/PathwayBrowser/#/R-DDI-2197690 Detachment of WASP/WAVE IEA Dictyostelium discoideum DDB_G0267956 R-DDI-9013145 https://reactome.org/PathwayBrowser/#/R-DDI-9013145 RAC1 binds effectors at the plasma membrane IEA Dictyostelium discoideum DDB_G0267956 R-DDI-9014294 https://reactome.org/PathwayBrowser/#/R-DDI-9014294 RAC2 binds effectors at the plasma membrane IEA Dictyostelium discoideum DDB_G0267956 R-DDI-9018808 https://reactome.org/PathwayBrowser/#/R-DDI-9018808 RAC3 binds effectors at the plasma membrane IEA Dictyostelium discoideum DDB_G0267960 R-DDI-6809011 https://reactome.org/PathwayBrowser/#/R-DDI-6809011 cis-Golgi t-SNAREs bind YKT6 on tethered vesicle IEA Dictyostelium discoideum DDB_G0267960 R-DDI-6811433 https://reactome.org/PathwayBrowser/#/R-DDI-6811433 The COG tethering complex interacts with numerous SNAREs at the Golgi membrane IEA Dictyostelium discoideum DDB_G0267960 R-DDI-8849748 https://reactome.org/PathwayBrowser/#/R-DDI-8849748 The COG complex binds RABs at the Golgi membrane IEA Dictyostelium discoideum DDB_G0267966 R-DDI-73585 https://reactome.org/PathwayBrowser/#/R-DDI-73585 uracil + NADPH + H+ => 5,6-dihydrouracil + NADP+ IEA Dictyostelium discoideum DDB_G0267966 R-DDI-73616 https://reactome.org/PathwayBrowser/#/R-DDI-73616 thymine + NADPH + H+ => 5,6-dihydrothymine + NADP+ IEA Dictyostelium discoideum DDB_G0267974 R-DDI-482772 https://reactome.org/PathwayBrowser/#/R-DDI-482772 Release of platelet cytosolic components IEA Dictyostelium discoideum DDB_G0267974 R-DDI-6798745 https://reactome.org/PathwayBrowser/#/R-DDI-6798745 Exocytosis of tertiary granule lumen proteins IEA Dictyostelium discoideum DDB_G0267974 R-DDI-6798749 https://reactome.org/PathwayBrowser/#/R-DDI-6798749 Exocytosis of specific granule lumen proteins IEA Dictyostelium discoideum DDB_G0267980 R-DDI-947514 https://reactome.org/PathwayBrowser/#/R-DDI-947514 PXLP-K198-NFS1 transfers sulfur from cysteine onto MOCS3 IEA Dictyostelium discoideum DDB_G0267982 R-DDI-6807872 https://reactome.org/PathwayBrowser/#/R-DDI-6807872 Active ARF recruits coatomer IEA Dictyostelium discoideum DDB_G0267982 R-DDI-6807875 https://reactome.org/PathwayBrowser/#/R-DDI-6807875 ARFGAP, cargo, v-SNAREs and p24 proteins bind nascent COPI complex IEA Dictyostelium discoideum DDB_G0267982 R-DDI-6807877 https://reactome.org/PathwayBrowser/#/R-DDI-6807877 ARFGAPs stimulate ARF GTPase activity IEA Dictyostelium discoideum DDB_G0267982 R-DDI-6809003 https://reactome.org/PathwayBrowser/#/R-DDI-6809003 ERGIC-to-Golgi vesicles bind dynein:dynactin IEA Dictyostelium discoideum DDB_G0267982 R-DDI-6809011 https://reactome.org/PathwayBrowser/#/R-DDI-6809011 cis-Golgi t-SNAREs bind YKT6 on tethered vesicle IEA Dictyostelium discoideum DDB_G0267982 R-DDI-6811412 https://reactome.org/PathwayBrowser/#/R-DDI-6811412 Active ARF recruits coatomer to the Golgi IEA Dictyostelium discoideum DDB_G0267982 R-DDI-6811417 https://reactome.org/PathwayBrowser/#/R-DDI-6811417 ARFGAP, cargo, vSNARES and p24 proteins bind COPI vesicles at Golgi IEA Dictyostelium discoideum DDB_G0267982 R-DDI-6811418 https://reactome.org/PathwayBrowser/#/R-DDI-6811418 ARFGAPs stimulate ARF GTPase activity at the Golgi membrane IEA Dictyostelium discoideum DDB_G0267982 R-DDI-6811427 https://reactome.org/PathwayBrowser/#/R-DDI-6811427 COPI vesicle uncoating at the ER IEA Dictyostelium discoideum DDB_G0267990 R-DDI-6798745 https://reactome.org/PathwayBrowser/#/R-DDI-6798745 Exocytosis of tertiary granule lumen proteins IEA Dictyostelium discoideum DDB_G0267990 R-DDI-6800434 https://reactome.org/PathwayBrowser/#/R-DDI-6800434 Exocytosis of ficolin-rich granule lumen proteins IEA Dictyostelium discoideum DDB_G0268014 R-DDI-109639 https://reactome.org/PathwayBrowser/#/R-DDI-109639 Formation of the closed pre-initiation complex IEA Dictyostelium discoideum DDB_G0268014 R-DDI-111264 https://reactome.org/PathwayBrowser/#/R-DDI-111264 Addition of nucleotides between position +11 and +30 IEA Dictyostelium discoideum DDB_G0268014 R-DDI-112383 https://reactome.org/PathwayBrowser/#/R-DDI-112383 Hypophosphorylation of RNA Pol II CTD by FCP1P protein IEA Dictyostelium discoideum DDB_G0268014 R-DDI-113430 https://reactome.org/PathwayBrowser/#/R-DDI-113430 Extrusion of 5'-end of 30 nt long transcript through the pore in Pol II complex IEA Dictyostelium discoideum DDB_G0268014 R-DDI-5690996 https://reactome.org/PathwayBrowser/#/R-DDI-5690996 ERCC2 and ERCC3 DNA helicases form an open bubble structure in damaged DNA IEA Dictyostelium discoideum DDB_G0268014 R-DDI-5691000 https://reactome.org/PathwayBrowser/#/R-DDI-5691000 TFIIH binds GG-NER site to form a verification complex IEA Dictyostelium discoideum DDB_G0268014 R-DDI-6781818 https://reactome.org/PathwayBrowser/#/R-DDI-6781818 RNA Pol II initiates transcription from damaged DNA template IEA Dictyostelium discoideum DDB_G0268014 R-DDI-6781824 https://reactome.org/PathwayBrowser/#/R-DDI-6781824 Active RNA Pol II complex transcribes lesion-containing DNA template IEA Dictyostelium discoideum DDB_G0268014 R-DDI-6781833 https://reactome.org/PathwayBrowser/#/R-DDI-6781833 ERCC8 (CSA) binds stalled RNA Pol II IEA Dictyostelium discoideum DDB_G0268014 R-DDI-6781840 https://reactome.org/PathwayBrowser/#/R-DDI-6781840 ERCC6 binds stalled RNA Pol II IEA Dictyostelium discoideum DDB_G0268014 R-DDI-6781867 https://reactome.org/PathwayBrowser/#/R-DDI-6781867 ERCC8:DDB1:CUL4:RBX1 ubiquitinates ERCC6 and RNA Pol II IEA Dictyostelium discoideum DDB_G0268014 R-DDI-6782069 https://reactome.org/PathwayBrowser/#/R-DDI-6782069 UVSSA:USP7 deubiquitinates ERCC6 IEA Dictyostelium discoideum DDB_G0268014 R-DDI-6782131 https://reactome.org/PathwayBrowser/#/R-DDI-6782131 ERCC2-facilitated RNA Pol II backtracking in TC-NER IEA Dictyostelium discoideum DDB_G0268014 R-DDI-6782141 https://reactome.org/PathwayBrowser/#/R-DDI-6782141 Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in TC-NER IEA Dictyostelium discoideum DDB_G0268014 R-DDI-6782204 https://reactome.org/PathwayBrowser/#/R-DDI-6782204 5' incision of damaged DNA strand by ERCC1:ERCC4 in TC-NER IEA Dictyostelium discoideum DDB_G0268014 R-DDI-6782208 https://reactome.org/PathwayBrowser/#/R-DDI-6782208 Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in TC-NER IEA Dictyostelium discoideum DDB_G0268014 R-DDI-6782211 https://reactome.org/PathwayBrowser/#/R-DDI-6782211 DNA polymerases delta, epsilon or kappa bind the TC-NER site IEA Dictyostelium discoideum DDB_G0268014 R-DDI-6782227 https://reactome.org/PathwayBrowser/#/R-DDI-6782227 Ligation of newly synthesized repair patch to incised DNA in TC-NER IEA Dictyostelium discoideum DDB_G0268014 R-DDI-6797606 https://reactome.org/PathwayBrowser/#/R-DDI-6797606 CDK12 phosphorylates RNA Pol II CTD at DNA repair genes IEA Dictyostelium discoideum DDB_G0268014 R-DDI-6797616 https://reactome.org/PathwayBrowser/#/R-DDI-6797616 CCNK:CDK12 binds RNA Pol II at DNA repair genes IEA Dictyostelium discoideum DDB_G0268014 R-DDI-73769 https://reactome.org/PathwayBrowser/#/R-DDI-73769 Loss of Rrn3 from RNA Polymerase I promoter escape complex IEA Dictyostelium discoideum DDB_G0268014 R-DDI-73946 https://reactome.org/PathwayBrowser/#/R-DDI-73946 Abortive initiation after formation of the first phosphodiester bond IEA Dictyostelium discoideum DDB_G0268014 R-DDI-74986 https://reactome.org/PathwayBrowser/#/R-DDI-74986 Elongation of pre-rRNA transcript IEA Dictyostelium discoideum DDB_G0268014 R-DDI-75850 https://reactome.org/PathwayBrowser/#/R-DDI-75850 Addition of the third nucleotide on the nascent transcript IEA Dictyostelium discoideum DDB_G0268014 R-DDI-75856 https://reactome.org/PathwayBrowser/#/R-DDI-75856 Abortive Initiation Before Second Transition IEA Dictyostelium discoideum DDB_G0268014 R-DDI-75861 https://reactome.org/PathwayBrowser/#/R-DDI-75861 NTP Binds Active Site of RNA Polymerase II IEA Dictyostelium discoideum DDB_G0268014 R-DDI-75862 https://reactome.org/PathwayBrowser/#/R-DDI-75862 Fall Back to Closed Pre-initiation Complex IEA Dictyostelium discoideum DDB_G0268014 R-DDI-75864 https://reactome.org/PathwayBrowser/#/R-DDI-75864 Newly Formed Phosphodiester Bond Stabilized and PPi Released IEA Dictyostelium discoideum DDB_G0268014 R-DDI-75866 https://reactome.org/PathwayBrowser/#/R-DDI-75866 Nucleophillic Attack by 3'-hydroxyl Oxygen of nascent transcript on the Alpha Phosphate of NTP IEA Dictyostelium discoideum DDB_G0268014 R-DDI-75869 https://reactome.org/PathwayBrowser/#/R-DDI-75869 Addition of the fourth nucleotide on the Nascent Transcript: Second Transition IEA Dictyostelium discoideum DDB_G0268014 R-DDI-75873 https://reactome.org/PathwayBrowser/#/R-DDI-75873 Addition of Nucleotides 5 through 9 on the growing Transcript IEA Dictyostelium discoideum DDB_G0268014 R-DDI-75891 https://reactome.org/PathwayBrowser/#/R-DDI-75891 Abortive Initiation After Second Transition IEA Dictyostelium discoideum DDB_G0268014 R-DDI-75949 https://reactome.org/PathwayBrowser/#/R-DDI-75949 RNA Polymerase II Promoter Opening: First Transition IEA Dictyostelium discoideum DDB_G0268014 R-DDI-76576 https://reactome.org/PathwayBrowser/#/R-DDI-76576 Addition of nucleotides 10 and 11 on the growing transcript: Third Transition IEA Dictyostelium discoideum DDB_G0268014 R-DDI-77068 https://reactome.org/PathwayBrowser/#/R-DDI-77068 Activation of GT IEA Dictyostelium discoideum DDB_G0268014 R-DDI-77069 https://reactome.org/PathwayBrowser/#/R-DDI-77069 RNA Polymerase II CTD (phosphorylated) binds to CE IEA Dictyostelium discoideum DDB_G0268014 R-DDI-77071 https://reactome.org/PathwayBrowser/#/R-DDI-77071 Phosphorylation (Ser5) of RNA pol II CTD IEA Dictyostelium discoideum DDB_G0268014 R-DDI-77073 https://reactome.org/PathwayBrowser/#/R-DDI-77073 SPT5 subunit of Pol II binds the RNA triphosphatase (RTP) IEA Dictyostelium discoideum DDB_G0268014 R-DDI-77077 https://reactome.org/PathwayBrowser/#/R-DDI-77077 Capping complex formation IEA Dictyostelium discoideum DDB_G0268014 R-DDI-77078 https://reactome.org/PathwayBrowser/#/R-DDI-77078 Hydrolysis of the 5'-end of the nascent transcript by the capping enzyme IEA Dictyostelium discoideum DDB_G0268014 R-DDI-77081 https://reactome.org/PathwayBrowser/#/R-DDI-77081 Formation of the CE:GMP intermediate complex IEA Dictyostelium discoideum DDB_G0268014 R-DDI-77083 https://reactome.org/PathwayBrowser/#/R-DDI-77083 Transfer of GMP from the capping enzyme GT site to 5'-end of mRNA IEA Dictyostelium discoideum DDB_G0268014 R-DDI-77085 https://reactome.org/PathwayBrowser/#/R-DDI-77085 Dissociation of transcript with 5'-GMP from GT IEA Dictyostelium discoideum DDB_G0268014 R-DDI-77090 https://reactome.org/PathwayBrowser/#/R-DDI-77090 Methylation of GMP-cap by RNA Methyltransferase IEA Dictyostelium discoideum DDB_G0268014 R-DDI-9613494 https://reactome.org/PathwayBrowser/#/R-DDI-9613494 Unwinding of DNA for the Nascent Transcript: Second Transition IEA Dictyostelium discoideum DDB_G0268014 R-DDI-9613497 https://reactome.org/PathwayBrowser/#/R-DDI-9613497 Unwinding DNA for the nascent transcript IEA Dictyostelium discoideum DDB_G0268014 R-DDI-9684118 https://reactome.org/PathwayBrowser/#/R-DDI-9684118 ERCC3-facilitated RNA Pol II backtracking in TC-NER IEA Dictyostelium discoideum DDB_G0268018 R-DDI-2161961 https://reactome.org/PathwayBrowser/#/R-DDI-2161961 5,6-EET is hydrolysed to 5,6-DHET by EPHX2 IEA Dictyostelium discoideum DDB_G0268018 R-DDI-9024993 https://reactome.org/PathwayBrowser/#/R-DDI-9024993 EPHX2 dimer hydrolyses 13(S),14(S)-epoxy-DHA to MaR2 IEA Dictyostelium discoideum DDB_G0268018 R-DDI-9033235 https://reactome.org/PathwayBrowser/#/R-DDI-9033235 Cargo of PEX5S,L translocates from the cytosol to the peroxisomal matrix IEA Dictyostelium discoideum DDB_G0268018 R-DDI-9033236 https://reactome.org/PathwayBrowser/#/R-DDI-9033236 PEX5S,L:Cargo binds PEX13:PEX14:PEX2:PEX10:PEX12 (Docking and Translocation Module) IEA Dictyostelium discoideum DDB_G0268018 R-DDI-9915968 https://reactome.org/PathwayBrowser/#/R-DDI-9915968 8,9-EET is hydrolysed to 8.9-DHET by EPHX2 IEA Dictyostelium discoideum DDB_G0268018 R-DDI-9915986 https://reactome.org/PathwayBrowser/#/R-DDI-9915986 11,12-EET is hydrolysed to 11,12-DHET by EPHX2 IEA Dictyostelium discoideum DDB_G0268018 R-DDI-9915994 https://reactome.org/PathwayBrowser/#/R-DDI-9915994 14,15-EET is hydrolysed to 14,15-DHET by EPHX2 IEA Dictyostelium discoideum DDB_G0268020 R-DDI-9859148 https://reactome.org/PathwayBrowser/#/R-DDI-9859148 BCKDHA:BCKDHB tetramer decarboxylates KIC, KMVA, KIV IEA Dictyostelium discoideum DDB_G0268020 R-DDI-9859163 https://reactome.org/PathwayBrowser/#/R-DDI-9859163 DBT transfers BCAA to CoA IEA Dictyostelium discoideum DDB_G0268020 R-DDI-9859172 https://reactome.org/PathwayBrowser/#/R-DDI-9859172 DLD dimer dehydrogenates dihydrolipoyl IEA Dictyostelium discoideum DDB_G0268024 R-DDI-1227670 https://reactome.org/PathwayBrowser/#/R-DDI-1227670 Recruitment of HDAC1 by p130 (RBL2) IEA Dictyostelium discoideum DDB_G0268024 R-DDI-1227671 https://reactome.org/PathwayBrowser/#/R-DDI-1227671 Recruitment of HDAC1 by p107 (RBL1) IEA Dictyostelium discoideum DDB_G0268024 R-DDI-2545253 https://reactome.org/PathwayBrowser/#/R-DDI-2545253 Deacetylation of cohesin IEA Dictyostelium discoideum DDB_G0268024 R-DDI-3769447 https://reactome.org/PathwayBrowser/#/R-DDI-3769447 HDAC1:2-containing complex deacetylate histones IEA Dictyostelium discoideum DDB_G0268024 R-DDI-3782637 https://reactome.org/PathwayBrowser/#/R-DDI-3782637 HDAC8 deacetylates histones IEA Dictyostelium discoideum DDB_G0268024 R-DDI-4615889 https://reactome.org/PathwayBrowser/#/R-DDI-4615889 SUMOylation of HDAC1 with SUMO1 IEA Dictyostelium discoideum DDB_G0268024 R-DDI-4616015 https://reactome.org/PathwayBrowser/#/R-DDI-4616015 SUMOylation of HDAC2 with SUMO1 IEA Dictyostelium discoideum DDB_G0268024 R-DDI-9679787 https://reactome.org/PathwayBrowser/#/R-DDI-9679787 HDAC1:2-containing complex binds HDAC2 Inhibitors IEA Dictyostelium discoideum DDB_G0268024 R-DDI-9701565 https://reactome.org/PathwayBrowser/#/R-DDI-9701565 HDACs deacetylate p-STAT3 dimers IEA Dictyostelium discoideum DDB_G0268034 R-DDI-6798748 https://reactome.org/PathwayBrowser/#/R-DDI-6798748 Exocytosis of secretory granule lumen proteins IEA Dictyostelium discoideum DDB_G0268034 R-DDI-6798751 https://reactome.org/PathwayBrowser/#/R-DDI-6798751 Exocytosis of azurophil granule lumen proteins IEA Dictyostelium discoideum DDB_G0268034 R-DDI-8875320 https://reactome.org/PathwayBrowser/#/R-DDI-8875320 RAB5 GEFs exchange GTP for GDP on RAB5 IEA Dictyostelium discoideum DDB_G0268034 R-DDI-8876191 https://reactome.org/PathwayBrowser/#/R-DDI-8876191 RAB9 GEFs exchange GTP for GDP on RAB9 IEA Dictyostelium discoideum DDB_G0268034 R-DDI-8876193 https://reactome.org/PathwayBrowser/#/R-DDI-8876193 RIC1-RGP1 exchanges GTP for GDP on RAB6 IEA Dictyostelium discoideum DDB_G0268034 R-DDI-8876454 https://reactome.org/PathwayBrowser/#/R-DDI-8876454 DENND3 exchanges GTP for GDP on RAB12 IEA Dictyostelium discoideum DDB_G0268034 R-DDI-8876615 https://reactome.org/PathwayBrowser/#/R-DDI-8876615 RAB13 GEFs exchange GTP for GDP on RAB13 IEA Dictyostelium discoideum DDB_G0268034 R-DDI-8876616 https://reactome.org/PathwayBrowser/#/R-DDI-8876616 DENND6A,B exchange GTP for GDP on RAB14 IEA Dictyostelium discoideum DDB_G0268034 R-DDI-8876837 https://reactome.org/PathwayBrowser/#/R-DDI-8876837 RAB21 GEFs exchange GTP for GDP on RAB21 IEA Dictyostelium discoideum DDB_G0268034 R-DDI-8877451 https://reactome.org/PathwayBrowser/#/R-DDI-8877451 MON1:CCZ1 exchanges GTP for GDP on RAB7 IEA Dictyostelium discoideum DDB_G0268034 R-DDI-8877475 https://reactome.org/PathwayBrowser/#/R-DDI-8877475 TRAPPC complexes exchange GTP for GDP on RAB1 IEA Dictyostelium discoideum DDB_G0268034 R-DDI-8877612 https://reactome.org/PathwayBrowser/#/R-DDI-8877612 DENND1s exchange GTP for GDP on RAB35 IEA Dictyostelium discoideum DDB_G0268034 R-DDI-8877998 https://reactome.org/PathwayBrowser/#/R-DDI-8877998 RAB3GAP1:RAB3GAP2 exchanges GTP for GDP on RAB18 IEA Dictyostelium discoideum DDB_G0268036 R-DDI-1237129 https://reactome.org/PathwayBrowser/#/R-DDI-1237129 Acireductone is created IEA Dictyostelium discoideum DDB_G0268038 R-DDI-8952039 https://reactome.org/PathwayBrowser/#/R-DDI-8952039 NEDD8:AcM-UBE2F binds CRL5 E3 ubiquitin ligase complex IEA Dictyostelium discoideum DDB_G0268038 R-DDI-8952044 https://reactome.org/PathwayBrowser/#/R-DDI-8952044 AcM-UBE2F transfers NEDD8 to CRL5 E3 ubiquitin ligase complex IEA Dictyostelium discoideum DDB_G0268038 R-DDI-8955241 https://reactome.org/PathwayBrowser/#/R-DDI-8955241 CAND1 binds cytosolic CRL E3 ubiquitin ligases IEA Dictyostelium discoideum DDB_G0268038 R-DDI-8955289 https://reactome.org/PathwayBrowser/#/R-DDI-8955289 COMMDs displace CAND1 from cytosolic CRL E3 ubiquitin ligase complexes IEA Dictyostelium discoideum DDB_G0268038 R-DDI-8956040 https://reactome.org/PathwayBrowser/#/R-DDI-8956040 COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes IEA Dictyostelium discoideum DDB_G0268038 R-DDI-983140 https://reactome.org/PathwayBrowser/#/R-DDI-983140 Transfer of Ub from E2 to substrate and release of E2 IEA Dictyostelium discoideum DDB_G0268038 R-DDI-983147 https://reactome.org/PathwayBrowser/#/R-DDI-983147 Release of E3 from polyubiquitinated substrate IEA Dictyostelium discoideum DDB_G0268038 R-DDI-983156 https://reactome.org/PathwayBrowser/#/R-DDI-983156 Polyubiquitination of substrate IEA Dictyostelium discoideum DDB_G0268038 R-DDI-983157 https://reactome.org/PathwayBrowser/#/R-DDI-983157 Interaction of E3 with substrate and E2-Ub complex IEA Dictyostelium discoideum DDB_G0268042 R-DDI-265295 https://reactome.org/PathwayBrowser/#/R-DDI-265295 Prostaglandin E synthase isomerizes PGH2 to PGE2 IEA Dictyostelium discoideum DDB_G0268042 R-DDI-3371586 https://reactome.org/PathwayBrowser/#/R-DDI-3371586 Dissociation of cytosolic HSF1:HSP90 complex IEA Dictyostelium discoideum DDB_G0268042 R-DDI-5082409 https://reactome.org/PathwayBrowser/#/R-DDI-5082409 Dissociation of HSF1:HSP90 complex in the nucleus IEA Dictyostelium discoideum DDB_G0268042 R-DDI-5324632 https://reactome.org/PathwayBrowser/#/R-DDI-5324632 Dissociation of cytosolic HSF1:HSP90:HDAC6:PTGES3 upon sensing protein aggregates IEA Dictyostelium discoideum DDB_G0268042 R-DDI-8936849 https://reactome.org/PathwayBrowser/#/R-DDI-8936849 AHR:2xHSP90:AIP:PTGES3 binds TCDD IEA Dictyostelium discoideum DDB_G0268042 R-DDI-8937169 https://reactome.org/PathwayBrowser/#/R-DDI-8937169 AHR:TCDD:2xHSP90AB1:AIP:PTGES3 translocates from cytosol to nucleoplasm IEA Dictyostelium discoideum DDB_G0268044 R-DDI-5694421 https://reactome.org/PathwayBrowser/#/R-DDI-5694421 PP6 dephosphorylates SEC24 IEA Dictyostelium discoideum DDB_G0268058 R-DDI-192033 https://reactome.org/PathwayBrowser/#/R-DDI-192033 4-cholesten-7alpha-ol-3-one is reduced to 5beta-cholestan-7alpha-ol-3-one IEA Dictyostelium discoideum DDB_G0268058 R-DDI-192036 https://reactome.org/PathwayBrowser/#/R-DDI-192036 5Beta-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholestan-3alpha, 7alpha, 12alpha-triol IEA Dictyostelium discoideum DDB_G0268058 R-DDI-192067 https://reactome.org/PathwayBrowser/#/R-DDI-192067 4-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholesten-7alpha, 12alpha-diol-3-one IEA Dictyostelium discoideum DDB_G0268058 R-DDI-192160 https://reactome.org/PathwayBrowser/#/R-DDI-192160 5beta-cholestan-7alpha-ol-3-one is reduced to 5beta-cholestan-3alpha, 7alpha-diol IEA Dictyostelium discoideum DDB_G0268058 R-DDI-193746 https://reactome.org/PathwayBrowser/#/R-DDI-193746 4-cholesten-7alpha,24(S)-diol-3-one is reduced to 5beta-cholestan-7alpha,24(S)-diol-3-one IEA Dictyostelium discoideum DDB_G0268058 R-DDI-193755 https://reactome.org/PathwayBrowser/#/R-DDI-193755 4-cholesten-7alpha,12alpha,24(S)-triol-3-one is reduced to 5beta-cholestan-7alpha,12alpha,24(S)-triol-3-one IEA Dictyostelium discoideum DDB_G0268058 R-DDI-193758 https://reactome.org/PathwayBrowser/#/R-DDI-193758 5beta-cholestan-7alpha,24(S)-diol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,24(S)-triol IEA Dictyostelium discoideum DDB_G0268058 R-DDI-193781 https://reactome.org/PathwayBrowser/#/R-DDI-193781 5Beta-cholestan-7alpha,12alpha,24(S)-triol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,12alpha,24(S)-tetrol IEA Dictyostelium discoideum DDB_G0268058 R-DDI-193800 https://reactome.org/PathwayBrowser/#/R-DDI-193800 5Beta-cholestan-7alpha,12alpha,27-triol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,12alpha,27-tetrol IEA Dictyostelium discoideum DDB_G0268058 R-DDI-193821 https://reactome.org/PathwayBrowser/#/R-DDI-193821 4-cholesten-7alpha,12alpha,27-triol-3-one is reduced to 5beta-cholestan-7alpha,12alpha,27-triol-3-one IEA Dictyostelium discoideum DDB_G0268058 R-DDI-193824 https://reactome.org/PathwayBrowser/#/R-DDI-193824 4-cholesten-7alpha,27-diol-3-one is reduced to 5beta-cholestan-7alpha,27-diol-3-one IEA Dictyostelium discoideum DDB_G0268058 R-DDI-193841 https://reactome.org/PathwayBrowser/#/R-DDI-193841 5beta-cholestan-7alpha,27-diol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,27-triol IEA Dictyostelium discoideum DDB_G0268058 R-DDI-2161549 https://reactome.org/PathwayBrowser/#/R-DDI-2161549 PGH2 is reduced to PGF2a by AKR1C3 IEA Dictyostelium discoideum DDB_G0268058 R-DDI-2161614 https://reactome.org/PathwayBrowser/#/R-DDI-2161614 PGD2 is reduced to 11-epi-PGF2a by AKRIC3 IEA Dictyostelium discoideum DDB_G0268058 R-DDI-5615668 https://reactome.org/PathwayBrowser/#/R-DDI-5615668 AKR1C3 reduces atRAL to atROL IEA Dictyostelium discoideum DDB_G0268058 R-DDI-5661256 https://reactome.org/PathwayBrowser/#/R-DDI-5661256 AKR1A1 reduces D-glucuronate to L-gulonate IEA Dictyostelium discoideum DDB_G0268058 R-DDI-5692232 https://reactome.org/PathwayBrowser/#/R-DDI-5692232 AKR1A1 oxidises BaPtDHD to BaP-7,8-dione IEA Dictyostelium discoideum DDB_G0268058 R-DDI-5696822 https://reactome.org/PathwayBrowser/#/R-DDI-5696822 AKR1B15 reduces EST17b to E1 IEA Dictyostelium discoideum DDB_G0268058 R-DDI-9758682 https://reactome.org/PathwayBrowser/#/R-DDI-9758682 AKR1C1 hydrogenates PREDN,PREDL IEA Dictyostelium discoideum DDB_G0268064 R-DDI-203613 https://reactome.org/PathwayBrowser/#/R-DDI-203613 Depalmitoylation of eNOS IEA Dictyostelium discoideum DDB_G0268064 R-DDI-9647991 https://reactome.org/PathwayBrowser/#/R-DDI-9647991 Palmostatin B binds RAS depalmitoylases IEA Dictyostelium discoideum DDB_G0268068 R-DDI-6798743 https://reactome.org/PathwayBrowser/#/R-DDI-6798743 Exocytosis of secretory granule membrane proteins IEA Dictyostelium discoideum DDB_G0268068 R-DDI-6811428 https://reactome.org/PathwayBrowser/#/R-DDI-6811428 RIC1:RGP1 recruits RAB6:GDP to the TGN IEA Dictyostelium discoideum DDB_G0268068 R-DDI-6811429 https://reactome.org/PathwayBrowser/#/R-DDI-6811429 RIC1:RGP1 stimulates nucleotide RAB6 nucleotide exchange IEA Dictyostelium discoideum DDB_G0268068 R-DDI-8849748 https://reactome.org/PathwayBrowser/#/R-DDI-8849748 The COG complex binds RABs at the Golgi membrane IEA Dictyostelium discoideum DDB_G0268068 R-DDI-8870466 https://reactome.org/PathwayBrowser/#/R-DDI-8870466 RGGT:CHM binds RABs IEA Dictyostelium discoideum DDB_G0268068 R-DDI-8870469 https://reactome.org/PathwayBrowser/#/R-DDI-8870469 RGGT geranylgeranylates RAB proteins IEA Dictyostelium discoideum DDB_G0268068 R-DDI-8876193 https://reactome.org/PathwayBrowser/#/R-DDI-8876193 RIC1-RGP1 exchanges GTP for GDP on RAB6 IEA Dictyostelium discoideum DDB_G0268074 R-DDI-427555 https://reactome.org/PathwayBrowser/#/R-DDI-427555 SLC26A1,2 cotransport SO4(2-), H+ from extracellular region to cytosol IEA Dictyostelium discoideum DDB_G0268074 R-DDI-427570 https://reactome.org/PathwayBrowser/#/R-DDI-427570 Group 3 - Selective Cl- transport IEA Dictyostelium discoideum DDB_G0268074 R-DDI-427666 https://reactome.org/PathwayBrowser/#/R-DDI-427666 SLC26A3,6 exchange Cl- for HCO3- IEA Dictyostelium discoideum DDB_G0268074 R-DDI-5627802 https://reactome.org/PathwayBrowser/#/R-DDI-5627802 SLC26A4 transports I- from cytosol to extracellular region IEA Dictyostelium discoideum DDB_G0268080 R-DDI-76056 https://reactome.org/PathwayBrowser/#/R-DDI-76056 Recruitment of RNA polymerase III to TFIIIB:TFIIIC:TFIIIA:Type 1 Promoter Complex IEA Dictyostelium discoideum DDB_G0268080 R-DDI-83805 https://reactome.org/PathwayBrowser/#/R-DDI-83805 Recruitment of RNA Polymerase III to the TFIIIB:TFIIIC: Type 2 Promoter Complex IEA Dictyostelium discoideum DDB_G0268098 R-DDI-4570467 https://reactome.org/PathwayBrowser/#/R-DDI-4570467 SUMOylation of NOP58 with SUMO1 IEA Dictyostelium discoideum DDB_G0268098 R-DDI-4570489 https://reactome.org/PathwayBrowser/#/R-DDI-4570489 SUMOylation of NOP58 with SUMO2 IEA Dictyostelium discoideum DDB_G0268098 R-DDI-6791222 https://reactome.org/PathwayBrowser/#/R-DDI-6791222 21S pre-rRNA is nucleolytically processed at site E (site2a) to yield 18SE pre-rRNA IEA Dictyostelium discoideum DDB_G0268098 R-DDI-6791227 https://reactome.org/PathwayBrowser/#/R-DDI-6791227 47S pre-rRNA is nucleolytically processed at A' (01,A1), site A0, and site 02 (site 6) to yield 45S pre-rRNA IEA Dictyostelium discoideum DDB_G0268104 R-DDI-916855 https://reactome.org/PathwayBrowser/#/R-DDI-916855 PXLP-K357-ABAT dimer:2Fe-2S transforms GABA to SUCCSA IEA Dictyostelium discoideum DDB_G0268132 R-DDI-4827383 https://reactome.org/PathwayBrowser/#/R-DDI-4827383 WHSC1 (KMT3G), NSD1 (KMT3B), SMYD2 (KMT3C) methylate lysine-37 of histone H3 (H3K36) IEA Dictyostelium discoideum DDB_G0268132 R-DDI-5159245 https://reactome.org/PathwayBrowser/#/R-DDI-5159245 SETD3, SETD7 (KMT7), WHSC1L1 (KMT3F), Core MLL complex methylate lysine-5 of histone H3 (H3K4) IEA Dictyostelium discoideum DDB_G0268132 R-DDI-5637686 https://reactome.org/PathwayBrowser/#/R-DDI-5637686 WHSC1L1 (KMT3F), Core MLL complex, SMYD3 (KMT3E) methylate methyl-lysine-5 of histone H3 (H3K4) IEA Dictyostelium discoideum DDB_G0268132 R-DDI-5638157 https://reactome.org/PathwayBrowser/#/R-DDI-5638157 WHSC1 (KMT3G), NSD1 (KMT3B), SMYD2 (KMT3C), ASH1L methylate methyl-lysine-37 of histone H3 (H3K36) IEA Dictyostelium discoideum DDB_G0268132 R-DDI-5638333 https://reactome.org/PathwayBrowser/#/R-DDI-5638333 WHSC1 (KMT3G) methylates lysine-28 of histone H3 (H3K27) IEA Dictyostelium discoideum DDB_G0268132 R-DDI-5649800 https://reactome.org/PathwayBrowser/#/R-DDI-5649800 WHSC1L1 (KMT3F) methylates methyl-lysine-28 of histone H3 (H3K27) IEA Dictyostelium discoideum DDB_G0268132 R-DDI-5649802 https://reactome.org/PathwayBrowser/#/R-DDI-5649802 WHSC1L1 (KMT3F) methylates dimethyl-lysine-28 of histone H3 (H3K27) IEA Dictyostelium discoideum DDB_G0268132 R-DDI-5682588 https://reactome.org/PathwayBrowser/#/R-DDI-5682588 RNF8 binds phosphorylated MDC1 at DNA DSBs IEA Dictyostelium discoideum DDB_G0268132 R-DDI-5682965 https://reactome.org/PathwayBrowser/#/R-DDI-5682965 WHSC1 dimethylates histone H4 on lysine K21 at DSBs IEA Dictyostelium discoideum DDB_G0268132 R-DDI-5682967 https://reactome.org/PathwayBrowser/#/R-DDI-5682967 WHSC1 binds DNA DSBs IEA Dictyostelium discoideum DDB_G0268132 R-DDI-5682983 https://reactome.org/PathwayBrowser/#/R-DDI-5682983 ATM phosphorylates WHSC1 IEA Dictyostelium discoideum DDB_G0268132 R-DDI-5683405 https://reactome.org/PathwayBrowser/#/R-DDI-5683405 PPP5C dephosphorylates TP53BP1 IEA Dictyostelium discoideum DDB_G0268132 R-DDI-5683425 https://reactome.org/PathwayBrowser/#/R-DDI-5683425 ATM phosphorylates TP53BP1 at DNA DSBs IEA Dictyostelium discoideum DDB_G0268132 R-DDI-5693566 https://reactome.org/PathwayBrowser/#/R-DDI-5693566 TP53BP1 associates with H4K20Me2 at DNA DSBs IEA Dictyostelium discoideum DDB_G0268138 R-DDI-176054 https://reactome.org/PathwayBrowser/#/R-DDI-176054 GST dimers conjugate GSH with cytosolic substrates IEA Dictyostelium discoideum DDB_G0268138 R-DDI-3343700 https://reactome.org/PathwayBrowser/#/R-DDI-3343700 PRDX6:GSTP1 catalyzes 2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O IEA Dictyostelium discoideum DDB_G0268138 R-DDI-6798748 https://reactome.org/PathwayBrowser/#/R-DDI-6798748 Exocytosis of secretory granule lumen proteins IEA Dictyostelium discoideum DDB_G0268138 R-DDI-6800434 https://reactome.org/PathwayBrowser/#/R-DDI-6800434 Exocytosis of ficolin-rich granule lumen proteins IEA Dictyostelium discoideum DDB_G0268138 R-DDI-9663492 https://reactome.org/PathwayBrowser/#/R-DDI-9663492 BIL dissociates from GSTA1, FABP1 IEA Dictyostelium discoideum DDB_G0268138 R-DDI-9663511 https://reactome.org/PathwayBrowser/#/R-DDI-9663511 BIL binds GSTA1, FABP1 IEA Dictyostelium discoideum DDB_G0268138 R-DDI-9748996 https://reactome.org/PathwayBrowser/#/R-DDI-9748996 GST dimers cleave AZA to 6MP IEA Dictyostelium discoideum DDB_G0268138 R-DDI-9753280 https://reactome.org/PathwayBrowser/#/R-DDI-9753280 GSTs transfer GSH to NAPQI to form APAP-SG IEA Dictyostelium discoideum DDB_G0268156 R-DDI-481007 https://reactome.org/PathwayBrowser/#/R-DDI-481007 Exocytosis of platelet alpha granule contents IEA Dictyostelium discoideum DDB_G0268156 R-DDI-8863721 https://reactome.org/PathwayBrowser/#/R-DDI-8863721 NEDD8-STON binds TOR1 hexamer and COP9 complex IEA Dictyostelium discoideum DDB_G0268156 R-DDI-8863723 https://reactome.org/PathwayBrowser/#/R-DDI-8863723 COP9 and TOR1 deneddylate STON2 IEA Dictyostelium discoideum DDB_G0268184 R-DDI-158546 https://reactome.org/PathwayBrowser/#/R-DDI-158546 UGTs glucuronate APAP to APAP-GlcA IEA Dictyostelium discoideum DDB_G0268184 R-DDI-159179 https://reactome.org/PathwayBrowser/#/R-DDI-159179 UGT1A4 transfers GlcA from UDP-GlcA to BMG to form BDG IEA Dictyostelium discoideum DDB_G0268184 R-DDI-159194 https://reactome.org/PathwayBrowser/#/R-DDI-159194 UGT1A4 transfers GlcA from UDP-GlcA to BIL to form BMG IEA Dictyostelium discoideum DDB_G0268184 R-DDI-174916 https://reactome.org/PathwayBrowser/#/R-DDI-174916 Formation of N-glucuronides IEA Dictyostelium discoideum DDB_G0268184 R-DDI-174931 https://reactome.org/PathwayBrowser/#/R-DDI-174931 UGTs transfer GlcA from UDP-GlcA to O-centre substrates IEA Dictyostelium discoideum DDB_G0268184 R-DDI-8941701 https://reactome.org/PathwayBrowser/#/R-DDI-8941701 UGT1A10 transfers GlcA from UDP-GlcA to GCTN IEA Dictyostelium discoideum DDB_G0268184 R-DDI-9749977 https://reactome.org/PathwayBrowser/#/R-DDI-9749977 UGT1A6 glucuronates ST IEA Dictyostelium discoideum DDB_G0268184 R-DDI-9756134 https://reactome.org/PathwayBrowser/#/R-DDI-9756134 UGT1A3 lactonizes 2-OH-ATV to 2-OH-ATVL IEA Dictyostelium discoideum DDB_G0268184 R-DDI-9756156 https://reactome.org/PathwayBrowser/#/R-DDI-9756156 UGT1A3 lactonizes ATV to ATVL IEA Dictyostelium discoideum DDB_G0268184 R-DDI-9756183 https://reactome.org/PathwayBrowser/#/R-DDI-9756183 UGT1A3 lactonizes 4-OH-ATV to 4-OH-ATVL IEA Dictyostelium discoideum DDB_G0268184 R-DDI-9758661 https://reactome.org/PathwayBrowser/#/R-DDI-9758661 UGT2B7,2B17,1A3 glucuronidates PRED metabolites IEA Dictyostelium discoideum DDB_G0268190 R-DDI-5693925 https://reactome.org/PathwayBrowser/#/R-DDI-5693925 FUT3 transfers L-fucose to Gal1,3GlcNAc IEA Dictyostelium discoideum DDB_G0268190 R-DDI-9603984 https://reactome.org/PathwayBrowser/#/R-DDI-9603984 FUT4,5,9,(10,11) transfer Fuc to Type 2 chains to form LeX IEA Dictyostelium discoideum DDB_G0268190 R-DDI-9603986 https://reactome.org/PathwayBrowser/#/R-DDI-9603986 FUT3 transfers Fuc to Type 1 chains to form LeA IEA Dictyostelium discoideum DDB_G0268190 R-DDI-9605609 https://reactome.org/PathwayBrowser/#/R-DDI-9605609 FUT3 transfers Fuc to Type 1 MSGG to form sLeA IEA Dictyostelium discoideum DDB_G0268190 R-DDI-9605644 https://reactome.org/PathwayBrowser/#/R-DDI-9605644 FUT3 transfers Fuc to Type 1 DSGG to form dsLeA IEA Dictyostelium discoideum DDB_G0268190 R-DDI-9605682 https://reactome.org/PathwayBrowser/#/R-DDI-9605682 FUT3,5,6,7 transfers Fuc to Type 2 MSGG to form sLeX IEA Dictyostelium discoideum DDB_G0268198 R-DDI-73757 https://reactome.org/PathwayBrowser/#/R-DDI-73757 Binding of RRN3 to RNA Polymerase I IEA Dictyostelium discoideum DDB_G0268198 R-DDI-73769 https://reactome.org/PathwayBrowser/#/R-DDI-73769 Loss of Rrn3 from RNA Polymerase I promoter escape complex IEA Dictyostelium discoideum DDB_G0268198 R-DDI-74986 https://reactome.org/PathwayBrowser/#/R-DDI-74986 Elongation of pre-rRNA transcript IEA Dictyostelium discoideum DDB_G0268214 R-DDI-70494 https://reactome.org/PathwayBrowser/#/R-DDI-70494 Enolase dimers (ENO1,2,3) convert PEP to 2PG IEA Dictyostelium discoideum DDB_G0268214 R-DDI-71660 https://reactome.org/PathwayBrowser/#/R-DDI-71660 2-Phospho-D-glycerate <=> Phosphoenolpyruvate + H2O IEA Dictyostelium discoideum DDB_G0268216 R-DDI-6785594 https://reactome.org/PathwayBrowser/#/R-DDI-6785594 FANCD2 binds FANCI IEA Dictyostelium discoideum DDB_G0268238 R-DDI-446188 https://reactome.org/PathwayBrowser/#/R-DDI-446188 ALG3 transfers Man to N-glycan precursor (GlcNAc)2 (Man)5 (PP-Dol)1 IEA Dictyostelium discoideum DDB_G0268244 R-DDI-429860 https://reactome.org/PathwayBrowser/#/R-DDI-429860 DCP1-DCP2 complex decaps mRNA IEA Dictyostelium discoideum DDB_G0268244 R-DDI-429978 https://reactome.org/PathwayBrowser/#/R-DDI-429978 Lsm1-7 Complex binds deadenylated mRNA IEA Dictyostelium discoideum DDB_G0268302 R-DDI-156826 https://reactome.org/PathwayBrowser/#/R-DDI-156826 Dissociation of L13a from the 60s ribosomal subunit IEA Dictyostelium discoideum DDB_G0268302 R-DDI-1799332 https://reactome.org/PathwayBrowser/#/R-DDI-1799332 Nascent polypeptide:mRNA:ribosome complex binds signal recognition particle (SRP) IEA Dictyostelium discoideum DDB_G0268302 R-DDI-72671 https://reactome.org/PathwayBrowser/#/R-DDI-72671 eIF5B:GTP is hydrolyzed and released IEA Dictyostelium discoideum DDB_G0268302 R-DDI-72672 https://reactome.org/PathwayBrowser/#/R-DDI-72672 The 60S subunit joins the translation initiation complex IEA Dictyostelium discoideum DDB_G0268302 R-DDI-72673 https://reactome.org/PathwayBrowser/#/R-DDI-72673 Release of 40S and 60S subunits from the 80S ribosome IEA Dictyostelium discoideum DDB_G0268302 R-DDI-927789 https://reactome.org/PathwayBrowser/#/R-DDI-927789 Formation of UPF1:eRF3 complex on mRNA with a premature termination codon and no Exon Junction Complex IEA Dictyostelium discoideum DDB_G0268302 R-DDI-927832 https://reactome.org/PathwayBrowser/#/R-DDI-927832 UPF1 binds an mRNP with a termination codon preceding an Exon Junction Complex IEA Dictyostelium discoideum DDB_G0268302 R-DDI-927889 https://reactome.org/PathwayBrowser/#/R-DDI-927889 SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex) IEA Dictyostelium discoideum DDB_G0268306 R-DDI-109638 https://reactome.org/PathwayBrowser/#/R-DDI-109638 Recruitment of RNA Polymerase II Holoenzyme by TFIIF to the pol II promoter:TFIID:TFIIA:TFIIB complex IEA Dictyostelium discoideum DDB_G0268306 R-DDI-109639 https://reactome.org/PathwayBrowser/#/R-DDI-109639 Formation of the closed pre-initiation complex IEA Dictyostelium discoideum DDB_G0268306 R-DDI-111264 https://reactome.org/PathwayBrowser/#/R-DDI-111264 Addition of nucleotides between position +11 and +30 IEA Dictyostelium discoideum DDB_G0268306 R-DDI-112383 https://reactome.org/PathwayBrowser/#/R-DDI-112383 Hypophosphorylation of RNA Pol II CTD by FCP1P protein IEA Dictyostelium discoideum DDB_G0268306 R-DDI-113407 https://reactome.org/PathwayBrowser/#/R-DDI-113407 DSIF complex binds to RNA Pol II (hypophosphorylated) IEA Dictyostelium discoideum DDB_G0268306 R-DDI-113409 https://reactome.org/PathwayBrowser/#/R-DDI-113409 Abortive termination of early transcription elongation by DSIF:NELF IEA Dictyostelium discoideum DDB_G0268306 R-DDI-113430 https://reactome.org/PathwayBrowser/#/R-DDI-113430 Extrusion of 5'-end of 30 nt long transcript through the pore in Pol II complex IEA Dictyostelium discoideum DDB_G0268306 R-DDI-6781818 https://reactome.org/PathwayBrowser/#/R-DDI-6781818 RNA Pol II initiates transcription from damaged DNA template IEA Dictyostelium discoideum DDB_G0268306 R-DDI-6781824 https://reactome.org/PathwayBrowser/#/R-DDI-6781824 Active RNA Pol II complex transcribes lesion-containing DNA template IEA Dictyostelium discoideum DDB_G0268306 R-DDI-6781833 https://reactome.org/PathwayBrowser/#/R-DDI-6781833 ERCC8 (CSA) binds stalled RNA Pol II IEA Dictyostelium discoideum DDB_G0268306 R-DDI-6781840 https://reactome.org/PathwayBrowser/#/R-DDI-6781840 ERCC6 binds stalled RNA Pol II IEA Dictyostelium discoideum DDB_G0268306 R-DDI-6781867 https://reactome.org/PathwayBrowser/#/R-DDI-6781867 ERCC8:DDB1:CUL4:RBX1 ubiquitinates ERCC6 and RNA Pol II IEA Dictyostelium discoideum DDB_G0268306 R-DDI-6782069 https://reactome.org/PathwayBrowser/#/R-DDI-6782069 UVSSA:USP7 deubiquitinates ERCC6 IEA Dictyostelium discoideum DDB_G0268306 R-DDI-6782131 https://reactome.org/PathwayBrowser/#/R-DDI-6782131 ERCC2-facilitated RNA Pol II backtracking in TC-NER IEA Dictyostelium discoideum DDB_G0268306 R-DDI-6782141 https://reactome.org/PathwayBrowser/#/R-DDI-6782141 Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in TC-NER IEA Dictyostelium discoideum DDB_G0268306 R-DDI-6782204 https://reactome.org/PathwayBrowser/#/R-DDI-6782204 5' incision of damaged DNA strand by ERCC1:ERCC4 in TC-NER IEA Dictyostelium discoideum DDB_G0268306 R-DDI-6782208 https://reactome.org/PathwayBrowser/#/R-DDI-6782208 Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in TC-NER IEA Dictyostelium discoideum DDB_G0268306 R-DDI-6782211 https://reactome.org/PathwayBrowser/#/R-DDI-6782211 DNA polymerases delta, epsilon or kappa bind the TC-NER site IEA Dictyostelium discoideum DDB_G0268306 R-DDI-6782227 https://reactome.org/PathwayBrowser/#/R-DDI-6782227 Ligation of newly synthesized repair patch to incised DNA in TC-NER IEA Dictyostelium discoideum DDB_G0268306 R-DDI-6797606 https://reactome.org/PathwayBrowser/#/R-DDI-6797606 CDK12 phosphorylates RNA Pol II CTD at DNA repair genes IEA Dictyostelium discoideum DDB_G0268306 R-DDI-6797616 https://reactome.org/PathwayBrowser/#/R-DDI-6797616 CCNK:CDK12 binds RNA Pol II at DNA repair genes IEA Dictyostelium discoideum DDB_G0268306 R-DDI-6810233 https://reactome.org/PathwayBrowser/#/R-DDI-6810233 CDK7 phosphorylates serine-5 and serine-7 of heptad repeats in C-terminal domain of RNA polymerase II at snRNA promoter IEA Dictyostelium discoideum DDB_G0268306 R-DDI-6810238 https://reactome.org/PathwayBrowser/#/R-DDI-6810238 RNA polymerase II binds initiation factors at promoter of snRNA gene (U1, U2, U4, U4atac, U5, U11, U12) IEA Dictyostelium discoideum DDB_G0268306 R-DDI-6814555 https://reactome.org/PathwayBrowser/#/R-DDI-6814555 Integrator complex processes the 3' end of snRNA IEA Dictyostelium discoideum DDB_G0268306 R-DDI-6814559 https://reactome.org/PathwayBrowser/#/R-DDI-6814559 Pre-snRNA is elongated and capped with 7-methylguanosine IEA Dictyostelium discoideum DDB_G0268306 R-DDI-72103 https://reactome.org/PathwayBrowser/#/R-DDI-72103 Formation of pre-mRNPs IEA Dictyostelium discoideum DDB_G0268306 R-DDI-73946 https://reactome.org/PathwayBrowser/#/R-DDI-73946 Abortive initiation after formation of the first phosphodiester bond IEA Dictyostelium discoideum DDB_G0268306 R-DDI-75095 https://reactome.org/PathwayBrowser/#/R-DDI-75095 Binding of TFIIE to the growing preinitiation complex IEA Dictyostelium discoideum DDB_G0268306 R-DDI-75850 https://reactome.org/PathwayBrowser/#/R-DDI-75850 Addition of the third nucleotide on the nascent transcript IEA Dictyostelium discoideum DDB_G0268306 R-DDI-75856 https://reactome.org/PathwayBrowser/#/R-DDI-75856 Abortive Initiation Before Second Transition IEA Dictyostelium discoideum DDB_G0268306 R-DDI-75861 https://reactome.org/PathwayBrowser/#/R-DDI-75861 NTP Binds Active Site of RNA Polymerase II IEA Dictyostelium discoideum DDB_G0268306 R-DDI-75862 https://reactome.org/PathwayBrowser/#/R-DDI-75862 Fall Back to Closed Pre-initiation Complex IEA Dictyostelium discoideum DDB_G0268306 R-DDI-75864 https://reactome.org/PathwayBrowser/#/R-DDI-75864 Newly Formed Phosphodiester Bond Stabilized and PPi Released IEA Dictyostelium discoideum DDB_G0268306 R-DDI-75866 https://reactome.org/PathwayBrowser/#/R-DDI-75866 Nucleophillic Attack by 3'-hydroxyl Oxygen of nascent transcript on the Alpha Phosphate of NTP IEA Dictyostelium discoideum DDB_G0268306 R-DDI-75869 https://reactome.org/PathwayBrowser/#/R-DDI-75869 Addition of the fourth nucleotide on the Nascent Transcript: Second Transition IEA Dictyostelium discoideum DDB_G0268306 R-DDI-75873 https://reactome.org/PathwayBrowser/#/R-DDI-75873 Addition of Nucleotides 5 through 9 on the growing Transcript IEA Dictyostelium discoideum DDB_G0268306 R-DDI-75891 https://reactome.org/PathwayBrowser/#/R-DDI-75891 Abortive Initiation After Second Transition IEA Dictyostelium discoideum DDB_G0268306 R-DDI-75949 https://reactome.org/PathwayBrowser/#/R-DDI-75949 RNA Polymerase II Promoter Opening: First Transition IEA Dictyostelium discoideum DDB_G0268306 R-DDI-76576 https://reactome.org/PathwayBrowser/#/R-DDI-76576 Addition of nucleotides 10 and 11 on the growing transcript: Third Transition IEA Dictyostelium discoideum DDB_G0268306 R-DDI-77068 https://reactome.org/PathwayBrowser/#/R-DDI-77068 Activation of GT IEA Dictyostelium discoideum DDB_G0268306 R-DDI-77069 https://reactome.org/PathwayBrowser/#/R-DDI-77069 RNA Polymerase II CTD (phosphorylated) binds to CE IEA Dictyostelium discoideum DDB_G0268306 R-DDI-77071 https://reactome.org/PathwayBrowser/#/R-DDI-77071 Phosphorylation (Ser5) of RNA pol II CTD IEA Dictyostelium discoideum DDB_G0268306 R-DDI-77073 https://reactome.org/PathwayBrowser/#/R-DDI-77073 SPT5 subunit of Pol II binds the RNA triphosphatase (RTP) IEA Dictyostelium discoideum DDB_G0268306 R-DDI-77077 https://reactome.org/PathwayBrowser/#/R-DDI-77077 Capping complex formation IEA Dictyostelium discoideum DDB_G0268306 R-DDI-77078 https://reactome.org/PathwayBrowser/#/R-DDI-77078 Hydrolysis of the 5'-end of the nascent transcript by the capping enzyme IEA Dictyostelium discoideum DDB_G0268306 R-DDI-77081 https://reactome.org/PathwayBrowser/#/R-DDI-77081 Formation of the CE:GMP intermediate complex IEA Dictyostelium discoideum DDB_G0268306 R-DDI-77083 https://reactome.org/PathwayBrowser/#/R-DDI-77083 Transfer of GMP from the capping enzyme GT site to 5'-end of mRNA IEA Dictyostelium discoideum DDB_G0268306 R-DDI-77085 https://reactome.org/PathwayBrowser/#/R-DDI-77085 Dissociation of transcript with 5'-GMP from GT IEA Dictyostelium discoideum DDB_G0268306 R-DDI-77090 https://reactome.org/PathwayBrowser/#/R-DDI-77090 Methylation of GMP-cap by RNA Methyltransferase IEA Dictyostelium discoideum DDB_G0268306 R-DDI-77095 https://reactome.org/PathwayBrowser/#/R-DDI-77095 Recognition and binding of the mRNA cap by the cap-binding complex IEA Dictyostelium discoideum DDB_G0268306 R-DDI-9012319 https://reactome.org/PathwayBrowser/#/R-DDI-9012319 p-TEFb phosphorylates serine 2 in RNA polymerase II CTD IEA Dictyostelium discoideum DDB_G0268306 R-DDI-9613494 https://reactome.org/PathwayBrowser/#/R-DDI-9613494 Unwinding of DNA for the Nascent Transcript: Second Transition IEA Dictyostelium discoideum DDB_G0268306 R-DDI-9613497 https://reactome.org/PathwayBrowser/#/R-DDI-9613497 Unwinding DNA for the nascent transcript IEA Dictyostelium discoideum DDB_G0268306 R-DDI-9684118 https://reactome.org/PathwayBrowser/#/R-DDI-9684118 ERCC3-facilitated RNA Pol II backtracking in TC-NER IEA Dictyostelium discoideum DDB_G0268306 R-DDI-9770236 https://reactome.org/PathwayBrowser/#/R-DDI-9770236 Formation of the Spliceosomal P complex and exon ligation IEA Dictyostelium discoideum DDB_G0268386 R-DDI-4827383 https://reactome.org/PathwayBrowser/#/R-DDI-4827383 WHSC1 (KMT3G), NSD1 (KMT3B), SMYD2 (KMT3C) methylate lysine-37 of histone H3 (H3K36) IEA Dictyostelium discoideum DDB_G0268386 R-DDI-5638157 https://reactome.org/PathwayBrowser/#/R-DDI-5638157 WHSC1 (KMT3G), NSD1 (KMT3B), SMYD2 (KMT3C), ASH1L methylate methyl-lysine-37 of histone H3 (H3K36) IEA Dictyostelium discoideum DDB_G0268402 R-DDI-6798743 https://reactome.org/PathwayBrowser/#/R-DDI-6798743 Exocytosis of secretory granule membrane proteins IEA Dictyostelium discoideum DDB_G0268402 R-DDI-8870466 https://reactome.org/PathwayBrowser/#/R-DDI-8870466 RGGT:CHM binds RABs IEA Dictyostelium discoideum DDB_G0268402 R-DDI-8870469 https://reactome.org/PathwayBrowser/#/R-DDI-8870469 RGGT geranylgeranylates RAB proteins IEA Dictyostelium discoideum DDB_G0268426 R-DDI-442422 https://reactome.org/PathwayBrowser/#/R-DDI-442422 SLC39A1-4 transports Zn2+ from extracellular region to cytosol IEA Dictyostelium discoideum DDB_G0268452 R-DDI-204008 https://reactome.org/PathwayBrowser/#/R-DDI-204008 SEC31:SEC13 and v-SNARE recruitment IEA Dictyostelium discoideum DDB_G0268452 R-DDI-5694409 https://reactome.org/PathwayBrowser/#/R-DDI-5694409 Nucleotide exchange on RAB1 IEA Dictyostelium discoideum DDB_G0268452 R-DDI-5694413 https://reactome.org/PathwayBrowser/#/R-DDI-5694413 SEC4C,D bind GOSR2 and STX5 IEA Dictyostelium discoideum DDB_G0268452 R-DDI-5694423 https://reactome.org/PathwayBrowser/#/R-DDI-5694423 NSF and SNAPs bind cis-SNARE complex IEA Dictyostelium discoideum DDB_G0268452 R-DDI-5694425 https://reactome.org/PathwayBrowser/#/R-DDI-5694425 NSF ATPase activity dissociates cis-SNARE IEA Dictyostelium discoideum DDB_G0268452 R-DDI-5694439 https://reactome.org/PathwayBrowser/#/R-DDI-5694439 COPII coat binds TRAPPCII and RAB1:GDP IEA Dictyostelium discoideum DDB_G0268452 R-DDI-5694441 https://reactome.org/PathwayBrowser/#/R-DDI-5694441 CSNK1D phosphorylates SEC23 IEA Dictyostelium discoideum DDB_G0268452 R-DDI-5694522 https://reactome.org/PathwayBrowser/#/R-DDI-5694522 Inner coat assembly and cargo binding IEA Dictyostelium discoideum DDB_G0268452 R-DDI-5694527 https://reactome.org/PathwayBrowser/#/R-DDI-5694527 Loss of SAR1B GTPase IEA Dictyostelium discoideum DDB_G0268452 R-DDI-6809011 https://reactome.org/PathwayBrowser/#/R-DDI-6809011 cis-Golgi t-SNAREs bind YKT6 on tethered vesicle IEA Dictyostelium discoideum DDB_G0268452 R-DDI-6809014 https://reactome.org/PathwayBrowser/#/R-DDI-6809014 cis-Golgi cis-SNARE binds NSF and SNAPs IEA Dictyostelium discoideum DDB_G0268452 R-DDI-6809015 https://reactome.org/PathwayBrowser/#/R-DDI-6809015 NSF ATPase activity dissociates cis-SNARE at cis-Golgi IEA Dictyostelium discoideum DDB_G0268452 R-DDI-6811433 https://reactome.org/PathwayBrowser/#/R-DDI-6811433 The COG tethering complex interacts with numerous SNAREs at the Golgi membrane IEA Dictyostelium discoideum DDB_G0268472 R-DDI-197186 https://reactome.org/PathwayBrowser/#/R-DDI-197186 NAPRT1 dimer transfers PRIB to NCA to form NAMN IEA Dictyostelium discoideum DDB_G0268472 R-DDI-6798751 https://reactome.org/PathwayBrowser/#/R-DDI-6798751 Exocytosis of azurophil granule lumen proteins IEA Dictyostelium discoideum DDB_G0268504 R-DDI-983140 https://reactome.org/PathwayBrowser/#/R-DDI-983140 Transfer of Ub from E2 to substrate and release of E2 IEA Dictyostelium discoideum DDB_G0268504 R-DDI-983147 https://reactome.org/PathwayBrowser/#/R-DDI-983147 Release of E3 from polyubiquitinated substrate IEA Dictyostelium discoideum DDB_G0268504 R-DDI-983156 https://reactome.org/PathwayBrowser/#/R-DDI-983156 Polyubiquitination of substrate IEA Dictyostelium discoideum DDB_G0268504 R-DDI-983157 https://reactome.org/PathwayBrowser/#/R-DDI-983157 Interaction of E3 with substrate and E2-Ub complex IEA Dictyostelium discoideum DDB_G0268520 R-DDI-8853379 https://reactome.org/PathwayBrowser/#/R-DDI-8853379 ENGASE hydrolyses unfolded protein:(GlcNAc)2 (Man(9-5) IEA Dictyostelium discoideum DDB_G0268522 R-DDI-9907912 https://reactome.org/PathwayBrowser/#/R-DDI-9907912 Formation of the outer ring of the 20S core particle IEA Dictyostelium discoideum DDB_G0268522 R-DDI-9907925 https://reactome.org/PathwayBrowser/#/R-DDI-9907925 Formation of the inner ring of the 20S immunoproteasome core particle IEA Dictyostelium discoideum DDB_G0268522 R-DDI-9907928 https://reactome.org/PathwayBrowser/#/R-DDI-9907928 Formation of the inner ring of the 20S thymoproteasome core particle IEA Dictyostelium discoideum DDB_G0268522 R-DDI-9908034 https://reactome.org/PathwayBrowser/#/R-DDI-9908034 PSMG3:PSMG4 dimer binds PSMA5 IEA Dictyostelium discoideum DDB_G0268522 R-DDI-9908041 https://reactome.org/PathwayBrowser/#/R-DDI-9908041 PSMG3 binds PSMG4 IEA Dictyostelium discoideum DDB_G0268522 R-DDI-9908052 https://reactome.org/PathwayBrowser/#/R-DDI-9908052 PSMG1:PSMG2 dimer binds the 20S core particle outer ring IEA Dictyostelium discoideum DDB_G0268522 R-DDI-9908069 https://reactome.org/PathwayBrowser/#/R-DDI-9908069 POMP binds the 20S core particle outer ring IEA Dictyostelium discoideum DDB_G0268538 R-DDI-1236970 https://reactome.org/PathwayBrowser/#/R-DDI-1236970 Proteasomal clevage of exogenous antigen (26S proteasome catalyst) IEA Dictyostelium discoideum DDB_G0268538 R-DDI-1504193 https://reactome.org/PathwayBrowser/#/R-DDI-1504193 Ubiquitinated DVL is degraded by the proteasome IEA Dictyostelium discoideum DDB_G0268538 R-DDI-174058 https://reactome.org/PathwayBrowser/#/R-DDI-174058 Degradation of multiubiquitinated Cdh1 IEA Dictyostelium discoideum DDB_G0268538 R-DDI-174105 https://reactome.org/PathwayBrowser/#/R-DDI-174105 Degradation of multiubiquitinated cell cycle proteins IEA Dictyostelium discoideum DDB_G0268538 R-DDI-174202 https://reactome.org/PathwayBrowser/#/R-DDI-174202 Degradation of multiubiquitinated Securin IEA Dictyostelium discoideum DDB_G0268538 R-DDI-188191 https://reactome.org/PathwayBrowser/#/R-DDI-188191 APC/C:Cdh1-mediated degradation of Skp2 IEA Dictyostelium discoideum DDB_G0268538 R-DDI-264458 https://reactome.org/PathwayBrowser/#/R-DDI-264458 Proteasome mediated degradation of COP1 IEA Dictyostelium discoideum DDB_G0268538 R-DDI-450466 https://reactome.org/PathwayBrowser/#/R-DDI-450466 AUF1:mRNA complex is destroyed IEA Dictyostelium discoideum DDB_G0268538 R-DDI-5635854 https://reactome.org/PathwayBrowser/#/R-DDI-5635854 GLI2,3 are degraded by the proteasome IEA Dictyostelium discoideum DDB_G0268538 R-DDI-5658430 https://reactome.org/PathwayBrowser/#/R-DDI-5658430 NF1 is degraded by the proteasome IEA Dictyostelium discoideum DDB_G0268538 R-DDI-5665854 https://reactome.org/PathwayBrowser/#/R-DDI-5665854 ADRM1:26S proteaseome binds UCHL5 IEA Dictyostelium discoideum DDB_G0268538 R-DDI-5665871 https://reactome.org/PathwayBrowser/#/R-DDI-5665871 ADRM1 binds 26S proteasome IEA Dictyostelium discoideum DDB_G0268538 R-DDI-5687112 https://reactome.org/PathwayBrowser/#/R-DDI-5687112 MAPK6 is degraded by the 26S proteasome IEA Dictyostelium discoideum DDB_G0268538 R-DDI-5689539 https://reactome.org/PathwayBrowser/#/R-DDI-5689539 ADRM1:26S proteaseome binds USP14 IEA Dictyostelium discoideum DDB_G0268538 R-DDI-6798748 https://reactome.org/PathwayBrowser/#/R-DDI-6798748 Exocytosis of secretory granule lumen proteins IEA Dictyostelium discoideum DDB_G0268538 R-DDI-6800434 https://reactome.org/PathwayBrowser/#/R-DDI-6800434 Exocytosis of ficolin-rich granule lumen proteins IEA Dictyostelium discoideum DDB_G0268538 R-DDI-68948 https://reactome.org/PathwayBrowser/#/R-DDI-68948 Ubiquitinated Orc1 is degraded by the proteasome IEA Dictyostelium discoideum DDB_G0268538 R-DDI-69016 https://reactome.org/PathwayBrowser/#/R-DDI-69016 Ubiquitinated Cdc6 is degraded by the proteasome IEA Dictyostelium discoideum DDB_G0268538 R-DDI-69600 https://reactome.org/PathwayBrowser/#/R-DDI-69600 Proteolytic degradation of ubiquitinated-Cdc25A IEA Dictyostelium discoideum DDB_G0268538 R-DDI-8850992 https://reactome.org/PathwayBrowser/#/R-DDI-8850992 Proteasome degrades polyubiquitinated PTEN IEA Dictyostelium discoideum DDB_G0268538 R-DDI-8854044 https://reactome.org/PathwayBrowser/#/R-DDI-8854044 Proteasome degrades AURKA ubiquitinated by SCF-FBXL7 IEA Dictyostelium discoideum DDB_G0268538 R-DDI-8866553 https://reactome.org/PathwayBrowser/#/R-DDI-8866553 misfolded CFTR is degraded by the 26S proteasome IEA Dictyostelium discoideum DDB_G0268538 R-DDI-9755306 https://reactome.org/PathwayBrowser/#/R-DDI-9755306 ub UBXN7 is degraded by the 26S proteasome IEA Dictyostelium discoideum DDB_G0268538 R-DDI-983150 https://reactome.org/PathwayBrowser/#/R-DDI-983150 Proteasomal cleavage of substrate IEA Dictyostelium discoideum DDB_G0268538 R-DDI-9907912 https://reactome.org/PathwayBrowser/#/R-DDI-9907912 Formation of the outer ring of the 20S core particle IEA Dictyostelium discoideum DDB_G0268538 R-DDI-9907919 https://reactome.org/PathwayBrowser/#/R-DDI-9907919 Formation of the preholoproteasome IEA Dictyostelium discoideum DDB_G0268538 R-DDI-9907925 https://reactome.org/PathwayBrowser/#/R-DDI-9907925 Formation of the inner ring of the 20S immunoproteasome core particle IEA Dictyostelium discoideum DDB_G0268538 R-DDI-9907928 https://reactome.org/PathwayBrowser/#/R-DDI-9907928 Formation of the inner ring of the 20S thymoproteasome core particle IEA Dictyostelium discoideum DDB_G0268538 R-DDI-9907940 https://reactome.org/PathwayBrowser/#/R-DDI-9907940 Formation of the preholothymoproteasome IEA Dictyostelium discoideum DDB_G0268538 R-DDI-9907941 https://reactome.org/PathwayBrowser/#/R-DDI-9907941 Fromation of the preholoimmunoproteasome IEA Dictyostelium discoideum DDB_G0268538 R-DDI-9908034 https://reactome.org/PathwayBrowser/#/R-DDI-9908034 PSMG3:PSMG4 dimer binds PSMA5 IEA Dictyostelium discoideum DDB_G0268538 R-DDI-9908052 https://reactome.org/PathwayBrowser/#/R-DDI-9908052 PSMG1:PSMG2 dimer binds the 20S core particle outer ring IEA Dictyostelium discoideum DDB_G0268538 R-DDI-9908069 https://reactome.org/PathwayBrowser/#/R-DDI-9908069 POMP binds the 20S core particle outer ring IEA Dictyostelium discoideum DDB_G0268538 R-DDI-9908178 https://reactome.org/PathwayBrowser/#/R-DDI-9908178 Formation of the 26S proteasome IEA Dictyostelium discoideum DDB_G0268538 R-DDI-9908709 https://reactome.org/PathwayBrowser/#/R-DDI-9908709 Formation of the PA28-alpha-beta-20S proteasome IEA Dictyostelium discoideum DDB_G0268538 R-DDI-9908721 https://reactome.org/PathwayBrowser/#/R-DDI-9908721 Formation of the PA28gamma-20S proteasome IEA Dictyostelium discoideum DDB_G0268540 R-DDI-158546 https://reactome.org/PathwayBrowser/#/R-DDI-158546 UGTs glucuronate APAP to APAP-GlcA IEA Dictyostelium discoideum DDB_G0268540 R-DDI-159179 https://reactome.org/PathwayBrowser/#/R-DDI-159179 UGT1A4 transfers GlcA from UDP-GlcA to BMG to form BDG IEA Dictyostelium discoideum DDB_G0268540 R-DDI-159194 https://reactome.org/PathwayBrowser/#/R-DDI-159194 UGT1A4 transfers GlcA from UDP-GlcA to BIL to form BMG IEA Dictyostelium discoideum DDB_G0268540 R-DDI-174916 https://reactome.org/PathwayBrowser/#/R-DDI-174916 Formation of N-glucuronides IEA Dictyostelium discoideum DDB_G0268540 R-DDI-174931 https://reactome.org/PathwayBrowser/#/R-DDI-174931 UGTs transfer GlcA from UDP-GlcA to O-centre substrates IEA Dictyostelium discoideum DDB_G0268540 R-DDI-8941701 https://reactome.org/PathwayBrowser/#/R-DDI-8941701 UGT1A10 transfers GlcA from UDP-GlcA to GCTN IEA Dictyostelium discoideum DDB_G0268540 R-DDI-9632038 https://reactome.org/PathwayBrowser/#/R-DDI-9632038 UGT1A1 tetramer transfers GlcA from UDP-GlcA to BMG to form BDG IEA Dictyostelium discoideum DDB_G0268540 R-DDI-9632039 https://reactome.org/PathwayBrowser/#/R-DDI-9632039 UGT1A1 transfers GlcA from UDP-GlcA to BIL to form BMG IEA Dictyostelium discoideum DDB_G0268540 R-DDI-9749977 https://reactome.org/PathwayBrowser/#/R-DDI-9749977 UGT1A6 glucuronates ST IEA Dictyostelium discoideum DDB_G0268540 R-DDI-9756134 https://reactome.org/PathwayBrowser/#/R-DDI-9756134 UGT1A3 lactonizes 2-OH-ATV to 2-OH-ATVL IEA Dictyostelium discoideum DDB_G0268540 R-DDI-9756156 https://reactome.org/PathwayBrowser/#/R-DDI-9756156 UGT1A3 lactonizes ATV to ATVL IEA Dictyostelium discoideum DDB_G0268540 R-DDI-9756183 https://reactome.org/PathwayBrowser/#/R-DDI-9756183 UGT1A3 lactonizes 4-OH-ATV to 4-OH-ATVL IEA Dictyostelium discoideum DDB_G0268540 R-DDI-9758661 https://reactome.org/PathwayBrowser/#/R-DDI-9758661 UGT2B7,2B17,1A3 glucuronidates PRED metabolites IEA Dictyostelium discoideum DDB_G0268544 R-DDI-158546 https://reactome.org/PathwayBrowser/#/R-DDI-158546 UGTs glucuronate APAP to APAP-GlcA IEA Dictyostelium discoideum DDB_G0268544 R-DDI-159179 https://reactome.org/PathwayBrowser/#/R-DDI-159179 UGT1A4 transfers GlcA from UDP-GlcA to BMG to form BDG IEA Dictyostelium discoideum DDB_G0268544 R-DDI-159194 https://reactome.org/PathwayBrowser/#/R-DDI-159194 UGT1A4 transfers GlcA from UDP-GlcA to BIL to form BMG IEA Dictyostelium discoideum DDB_G0268544 R-DDI-174916 https://reactome.org/PathwayBrowser/#/R-DDI-174916 Formation of N-glucuronides IEA Dictyostelium discoideum DDB_G0268544 R-DDI-174931 https://reactome.org/PathwayBrowser/#/R-DDI-174931 UGTs transfer GlcA from UDP-GlcA to O-centre substrates IEA Dictyostelium discoideum DDB_G0268544 R-DDI-8941701 https://reactome.org/PathwayBrowser/#/R-DDI-8941701 UGT1A10 transfers GlcA from UDP-GlcA to GCTN IEA Dictyostelium discoideum DDB_G0268544 R-DDI-9749977 https://reactome.org/PathwayBrowser/#/R-DDI-9749977 UGT1A6 glucuronates ST IEA Dictyostelium discoideum DDB_G0268544 R-DDI-9756134 https://reactome.org/PathwayBrowser/#/R-DDI-9756134 UGT1A3 lactonizes 2-OH-ATV to 2-OH-ATVL IEA Dictyostelium discoideum DDB_G0268544 R-DDI-9756156 https://reactome.org/PathwayBrowser/#/R-DDI-9756156 UGT1A3 lactonizes ATV to ATVL IEA Dictyostelium discoideum DDB_G0268544 R-DDI-9756183 https://reactome.org/PathwayBrowser/#/R-DDI-9756183 UGT1A3 lactonizes 4-OH-ATV to 4-OH-ATVL IEA Dictyostelium discoideum DDB_G0268544 R-DDI-9758661 https://reactome.org/PathwayBrowser/#/R-DDI-9758661 UGT2B7,2B17,1A3 glucuronidates PRED metabolites IEA Dictyostelium discoideum DDB_G0268548 R-DDI-1675928 https://reactome.org/PathwayBrowser/#/R-DDI-1675928 PI4P is phosphorylated to PI(3,4)P2 by PIK3C2A/G at the Golgi membrane IEA Dictyostelium discoideum DDB_G0268548 R-DDI-1675939 https://reactome.org/PathwayBrowser/#/R-DDI-1675939 PI is phosphorylated to PI3P by PIK3C2A/3 at the early endosome membrane IEA Dictyostelium discoideum DDB_G0268548 R-DDI-1675961 https://reactome.org/PathwayBrowser/#/R-DDI-1675961 PI is phosphorylated to PI3P by PIK3C2A/3 at the Golgi membrane IEA Dictyostelium discoideum DDB_G0268548 R-DDI-1676024 https://reactome.org/PathwayBrowser/#/R-DDI-1676024 PI is phosphorylated to PI3P by PIK3C2A/3 at the late endosome membrane IEA Dictyostelium discoideum DDB_G0268548 R-DDI-1676048 https://reactome.org/PathwayBrowser/#/R-DDI-1676048 PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane IEA Dictyostelium discoideum DDB_G0268548 R-DDI-1676109 https://reactome.org/PathwayBrowser/#/R-DDI-1676109 PI4P is phosphorylated to PI(3,4)P2 by PI3K3C[2] at the plasma membrane IEA Dictyostelium discoideum DDB_G0268548 R-DDI-1676206 https://reactome.org/PathwayBrowser/#/R-DDI-1676206 PI4P is phosphorylated to PI(3,4)P2 by PIK3C2A at the early endosome membrane IEA Dictyostelium discoideum DDB_G0268548 R-DDI-392300 https://reactome.org/PathwayBrowser/#/R-DDI-392300 G beta:gamma activated PI3Kgamma converts PIP2 to PIP3 IEA Dictyostelium discoideum DDB_G0268548 R-DDI-437162 https://reactome.org/PathwayBrowser/#/R-DDI-437162 PI3K alpha, beta, gamma convert PIP2 to PIP3 IEA Dictyostelium discoideum DDB_G0268548 R-DDI-8868072 https://reactome.org/PathwayBrowser/#/R-DDI-8868072 Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2 IEA Dictyostelium discoideum DDB_G0268562 R-DDI-192033 https://reactome.org/PathwayBrowser/#/R-DDI-192033 4-cholesten-7alpha-ol-3-one is reduced to 5beta-cholestan-7alpha-ol-3-one IEA Dictyostelium discoideum DDB_G0268562 R-DDI-192036 https://reactome.org/PathwayBrowser/#/R-DDI-192036 5Beta-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholestan-3alpha, 7alpha, 12alpha-triol IEA Dictyostelium discoideum DDB_G0268562 R-DDI-192067 https://reactome.org/PathwayBrowser/#/R-DDI-192067 4-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholesten-7alpha, 12alpha-diol-3-one IEA Dictyostelium discoideum DDB_G0268562 R-DDI-192160 https://reactome.org/PathwayBrowser/#/R-DDI-192160 5beta-cholestan-7alpha-ol-3-one is reduced to 5beta-cholestan-3alpha, 7alpha-diol IEA Dictyostelium discoideum DDB_G0268562 R-DDI-193746 https://reactome.org/PathwayBrowser/#/R-DDI-193746 4-cholesten-7alpha,24(S)-diol-3-one is reduced to 5beta-cholestan-7alpha,24(S)-diol-3-one IEA Dictyostelium discoideum DDB_G0268562 R-DDI-193755 https://reactome.org/PathwayBrowser/#/R-DDI-193755 4-cholesten-7alpha,12alpha,24(S)-triol-3-one is reduced to 5beta-cholestan-7alpha,12alpha,24(S)-triol-3-one IEA Dictyostelium discoideum DDB_G0268562 R-DDI-193758 https://reactome.org/PathwayBrowser/#/R-DDI-193758 5beta-cholestan-7alpha,24(S)-diol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,24(S)-triol IEA Dictyostelium discoideum DDB_G0268562 R-DDI-193781 https://reactome.org/PathwayBrowser/#/R-DDI-193781 5Beta-cholestan-7alpha,12alpha,24(S)-triol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,12alpha,24(S)-tetrol IEA Dictyostelium discoideum DDB_G0268562 R-DDI-193800 https://reactome.org/PathwayBrowser/#/R-DDI-193800 5Beta-cholestan-7alpha,12alpha,27-triol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,12alpha,27-tetrol IEA Dictyostelium discoideum DDB_G0268562 R-DDI-193821 https://reactome.org/PathwayBrowser/#/R-DDI-193821 4-cholesten-7alpha,12alpha,27-triol-3-one is reduced to 5beta-cholestan-7alpha,12alpha,27-triol-3-one IEA Dictyostelium discoideum DDB_G0268562 R-DDI-193824 https://reactome.org/PathwayBrowser/#/R-DDI-193824 4-cholesten-7alpha,27-diol-3-one is reduced to 5beta-cholestan-7alpha,27-diol-3-one IEA Dictyostelium discoideum DDB_G0268562 R-DDI-193841 https://reactome.org/PathwayBrowser/#/R-DDI-193841 5beta-cholestan-7alpha,27-diol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,27-triol IEA Dictyostelium discoideum DDB_G0268562 R-DDI-2161549 https://reactome.org/PathwayBrowser/#/R-DDI-2161549 PGH2 is reduced to PGF2a by AKR1C3 IEA Dictyostelium discoideum DDB_G0268562 R-DDI-2161614 https://reactome.org/PathwayBrowser/#/R-DDI-2161614 PGD2 is reduced to 11-epi-PGF2a by AKRIC3 IEA Dictyostelium discoideum DDB_G0268562 R-DDI-5615668 https://reactome.org/PathwayBrowser/#/R-DDI-5615668 AKR1C3 reduces atRAL to atROL IEA Dictyostelium discoideum DDB_G0268562 R-DDI-5661256 https://reactome.org/PathwayBrowser/#/R-DDI-5661256 AKR1A1 reduces D-glucuronate to L-gulonate IEA Dictyostelium discoideum DDB_G0268562 R-DDI-5692232 https://reactome.org/PathwayBrowser/#/R-DDI-5692232 AKR1A1 oxidises BaPtDHD to BaP-7,8-dione IEA Dictyostelium discoideum DDB_G0268562 R-DDI-5696822 https://reactome.org/PathwayBrowser/#/R-DDI-5696822 AKR1B15 reduces EST17b to E1 IEA Dictyostelium discoideum DDB_G0268562 R-DDI-9758682 https://reactome.org/PathwayBrowser/#/R-DDI-9758682 AKR1C1 hydrogenates PREDN,PREDL IEA Dictyostelium discoideum DDB_G0268564 R-DDI-9603775 https://reactome.org/PathwayBrowser/#/R-DDI-9603775 PEX3:PEX19:class I PMP dissociates IEA Dictyostelium discoideum DDB_G0268564 R-DDI-9603784 https://reactome.org/PathwayBrowser/#/R-DDI-9603784 PEX19:class I PMP binds PEX3 IEA Dictyostelium discoideum DDB_G0268564 R-DDI-9603804 https://reactome.org/PathwayBrowser/#/R-DDI-9603804 PEX19 binds class I peroxisomal membrane proteins IEA Dictyostelium discoideum DDB_G0268574 R-DDI-156823 https://reactome.org/PathwayBrowser/#/R-DDI-156823 Association of phospho-L13a with GAIT element of Ceruloplasmin mRNA IEA Dictyostelium discoideum DDB_G0268574 R-DDI-165692 https://reactome.org/PathwayBrowser/#/R-DDI-165692 Phosphorylation of 4E-BP1 by activated mTORC1 IEA Dictyostelium discoideum DDB_G0268574 R-DDI-165708 https://reactome.org/PathwayBrowser/#/R-DDI-165708 Dissociation of phosphorylated 4EBP1 from eIF4E IEA Dictyostelium discoideum DDB_G0268574 R-DDI-1678842 https://reactome.org/PathwayBrowser/#/R-DDI-1678842 Competitive inhibition of translation initiation by ISGylated 4EHP IEA Dictyostelium discoideum DDB_G0268574 R-DDI-72621 https://reactome.org/PathwayBrowser/#/R-DDI-72621 Ribosomal scanning IEA Dictyostelium discoideum DDB_G0268574 R-DDI-72622 https://reactome.org/PathwayBrowser/#/R-DDI-72622 Release of eIF4E from the inactive eIF4E:4E-BP complex IEA Dictyostelium discoideum DDB_G0268574 R-DDI-72631 https://reactome.org/PathwayBrowser/#/R-DDI-72631 Formation of the cap-binding eIF4F complex IEA Dictyostelium discoideum DDB_G0268574 R-DDI-72697 https://reactome.org/PathwayBrowser/#/R-DDI-72697 Start codon recognition IEA Dictyostelium discoideum DDB_G0268578 R-DDI-205039 https://reactome.org/PathwayBrowser/#/R-DDI-205039 p75NTR indirectly activates RAC and Cdc42 via a guanyl-nucleotide exchange factor IEA Dictyostelium discoideum DDB_G0268578 R-DDI-9013143 https://reactome.org/PathwayBrowser/#/R-DDI-9013143 RAC1 GEFs activate RAC1 IEA Dictyostelium discoideum DDB_G0268578 R-DDI-9013159 https://reactome.org/PathwayBrowser/#/R-DDI-9013159 CDC42 GEFs activate CDC42 IEA Dictyostelium discoideum DDB_G0268614 R-DDI-5358510 https://reactome.org/PathwayBrowser/#/R-DDI-5358510 MSH2:MSH6 recruits MLH1:PMS2 to mismatch and interacts with PCNA IEA Dictyostelium discoideum DDB_G0268614 R-DDI-5358518 https://reactome.org/PathwayBrowser/#/R-DDI-5358518 MLH1:PMS2 makes single strand incision near 1-2 base mismatch IEA Dictyostelium discoideum DDB_G0268614 R-DDI-5358525 https://reactome.org/PathwayBrowser/#/R-DDI-5358525 MSH2:MSH6 binds 1 base mismatch or 1-2 base insertion/deletion loop IEA Dictyostelium discoideum DDB_G0268614 R-DDI-5358597 https://reactome.org/PathwayBrowser/#/R-DDI-5358597 EXO1 interacts with MSH2:MSH6 (MutSalpha) and MLH1:PMS2 (MutLalpha) IEA Dictyostelium discoideum DDB_G0268614 R-DDI-5358912 https://reactome.org/PathwayBrowser/#/R-DDI-5358912 MSH2:MSH6 exchanges ADP for ATP IEA Dictyostelium discoideum DDB_G0268614 R-DDI-5444516 https://reactome.org/PathwayBrowser/#/R-DDI-5444516 Formation of MSH2:MSH6 Complex IEA Dictyostelium discoideum DDB_G0268618 R-DDI-8877692 https://reactome.org/PathwayBrowser/#/R-DDI-8877692 PIN1 binds phosphorylated PIP4K2B IEA Dictyostelium discoideum DDB_G0268620 R-DDI-109700 https://reactome.org/PathwayBrowser/#/R-DDI-109700 AKT2 binds PIP3 IEA Dictyostelium discoideum DDB_G0268620 R-DDI-109702 https://reactome.org/PathwayBrowser/#/R-DDI-109702 PDPK1 phosphorylates AKT2 IEA Dictyostelium discoideum DDB_G0268620 R-DDI-114553 https://reactome.org/PathwayBrowser/#/R-DDI-114553 Activation of conventional Protein Kinase C IEA Dictyostelium discoideum DDB_G0268620 R-DDI-114683 https://reactome.org/PathwayBrowser/#/R-DDI-114683 Phosphorylation of Platelet Sec-1 IEA Dictyostelium discoideum DDB_G0268620 R-DDI-114684 https://reactome.org/PathwayBrowser/#/R-DDI-114684 Phosphorylation of Syntaxin-4 IEA Dictyostelium discoideum DDB_G0268620 R-DDI-1168373 https://reactome.org/PathwayBrowser/#/R-DDI-1168373 PRKCB (Protein kinase C beta, PKC-beta) binds diacylglycerol and phosphatidylserine IEA Dictyostelium discoideum DDB_G0268620 R-DDI-1358791 https://reactome.org/PathwayBrowser/#/R-DDI-1358791 Phosphorylation of USP8 by P-AKT IEA Dictyostelium discoideum DDB_G0268620 R-DDI-1497784 https://reactome.org/PathwayBrowser/#/R-DDI-1497784 The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle IEA Dictyostelium discoideum DDB_G0268620 R-DDI-1497796 https://reactome.org/PathwayBrowser/#/R-DDI-1497796 BH2 binding can lead to eNOS uncoupling IEA Dictyostelium discoideum DDB_G0268620 R-DDI-1497810 https://reactome.org/PathwayBrowser/#/R-DDI-1497810 Uncoupled eNOS favours the formation of superoxide IEA Dictyostelium discoideum DDB_G0268620 R-DDI-165162 https://reactome.org/PathwayBrowser/#/R-DDI-165162 Phosphorylation of TSC2 by PKB IEA Dictyostelium discoideum DDB_G0268620 R-DDI-198314 https://reactome.org/PathwayBrowser/#/R-DDI-198314 DAG stimulates protein kinase C-delta IEA Dictyostelium discoideum DDB_G0268620 R-DDI-198609 https://reactome.org/PathwayBrowser/#/R-DDI-198609 AKT phosphorylates TSC2, inhibiting it IEA Dictyostelium discoideum DDB_G0268620 R-DDI-198640 https://reactome.org/PathwayBrowser/#/R-DDI-198640 TORC2 (mTOR) phosphorylates AKT at S473 IEA Dictyostelium discoideum DDB_G0268620 R-DDI-199443 https://reactome.org/PathwayBrowser/#/R-DDI-199443 THEM4 (CTMP) and/or TRIB3 inhibit AKT phosphorylation IEA Dictyostelium discoideum DDB_G0268620 R-DDI-199839 https://reactome.org/PathwayBrowser/#/R-DDI-199839 AKT can phosphorylate RSK IEA Dictyostelium discoideum DDB_G0268620 R-DDI-202111 https://reactome.org/PathwayBrowser/#/R-DDI-202111 AKT1 phosphorylates eNOS IEA Dictyostelium discoideum DDB_G0268620 R-DDI-202127 https://reactome.org/PathwayBrowser/#/R-DDI-202127 eNOS synthesizes NO IEA Dictyostelium discoideum DDB_G0268620 R-DDI-202137 https://reactome.org/PathwayBrowser/#/R-DDI-202137 AKT1 binds eNOS complex via HSP90 IEA Dictyostelium discoideum DDB_G0268620 R-DDI-202222 https://reactome.org/PathwayBrowser/#/R-DDI-202222 Phosphorylation of PKC theta IEA Dictyostelium discoideum DDB_G0268620 R-DDI-202328 https://reactome.org/PathwayBrowser/#/R-DDI-202328 Translocation of PKC theta to plasma membrane IEA Dictyostelium discoideum DDB_G0268620 R-DDI-2317314 https://reactome.org/PathwayBrowser/#/R-DDI-2317314 AKT binds PDPK1 IEA Dictyostelium discoideum DDB_G0268620 R-DDI-2317332 https://reactome.org/PathwayBrowser/#/R-DDI-2317332 PIP3 recruits AKT to the membrane IEA Dictyostelium discoideum DDB_G0268620 R-DDI-2730835 https://reactome.org/PathwayBrowser/#/R-DDI-2730835 Autophosphorylation of PKC-theta IEA Dictyostelium discoideum DDB_G0268620 R-DDI-377186 https://reactome.org/PathwayBrowser/#/R-DDI-377186 Activated Akt1 phosphorylates AKT1S1 (PRAS40) IEA Dictyostelium discoideum DDB_G0268620 R-DDI-390329 https://reactome.org/PathwayBrowser/#/R-DDI-390329 Dephosphorylation of AKT by PP2A IEA Dictyostelium discoideum DDB_G0268620 R-DDI-400015 https://reactome.org/PathwayBrowser/#/R-DDI-400015 Diacylgycerol activates Protein kinase C, alpha type IEA Dictyostelium discoideum DDB_G0268620 R-DDI-425861 https://reactome.org/PathwayBrowser/#/R-DDI-425861 Activation of Protein Kinase C novel isoforms IEA Dictyostelium discoideum DDB_G0268620 R-DDI-450490 https://reactome.org/PathwayBrowser/#/R-DDI-450490 Protein Kinase B/Akt phosphorylates BRF1 IEA Dictyostelium discoideum DDB_G0268620 R-DDI-5218805 https://reactome.org/PathwayBrowser/#/R-DDI-5218805 PKC autophosphorylates IEA Dictyostelium discoideum DDB_G0268620 R-DDI-5218813 https://reactome.org/PathwayBrowser/#/R-DDI-5218813 DAG and Ca+2 bind to PKC and tether it to membrane IEA Dictyostelium discoideum DDB_G0268620 R-DDI-5218821 https://reactome.org/PathwayBrowser/#/R-DDI-5218821 PDK1 phosphorylates PKC IEA Dictyostelium discoideum DDB_G0268620 R-DDI-5218823 https://reactome.org/PathwayBrowser/#/R-DDI-5218823 PKC phosphorylates sphingosine kinase 1 IEA Dictyostelium discoideum DDB_G0268620 R-DDI-5223304 https://reactome.org/PathwayBrowser/#/R-DDI-5223304 DAG and Ca+2 bind to PKC and tether it to membrane IEA Dictyostelium discoideum DDB_G0268620 R-DDI-5607734 https://reactome.org/PathwayBrowser/#/R-DDI-5607734 PKC-delta translocates to plasma membrane IEA Dictyostelium discoideum DDB_G0268620 R-DDI-5607746 https://reactome.org/PathwayBrowser/#/R-DDI-5607746 PKC-delta is activated IEA Dictyostelium discoideum DDB_G0268620 R-DDI-5625784 https://reactome.org/PathwayBrowser/#/R-DDI-5625784 PKN1 phosphorylates histone 3 of nucleosomes associate with KLK2 and KLK3 promoters IEA Dictyostelium discoideum DDB_G0268620 R-DDI-5671737 https://reactome.org/PathwayBrowser/#/R-DDI-5671737 p-T774-PKN1 binds CDC25C IEA Dictyostelium discoideum DDB_G0268620 R-DDI-5671749 https://reactome.org/PathwayBrowser/#/R-DDI-5671749 p-T774-PKN1 phosphorylates CDC25C IEA Dictyostelium discoideum DDB_G0268620 R-DDI-6795290 https://reactome.org/PathwayBrowser/#/R-DDI-6795290 TORC2 complex phosphorylates SGK1 IEA Dictyostelium discoideum DDB_G0268620 R-DDI-6795473 https://reactome.org/PathwayBrowser/#/R-DDI-6795473 PDPK1 phosphorylates SGK1 IEA Dictyostelium discoideum DDB_G0268620 R-DDI-6798751 https://reactome.org/PathwayBrowser/#/R-DDI-6798751 Exocytosis of azurophil granule lumen proteins IEA Dictyostelium discoideum DDB_G0268620 R-DDI-6805640 https://reactome.org/PathwayBrowser/#/R-DDI-6805640 AKT phosphorylates KAT6A IEA Dictyostelium discoideum DDB_G0268620 R-DDI-6811504 https://reactome.org/PathwayBrowser/#/R-DDI-6811504 AKT1 dephosphorylation by PP2A-B56-beta,gamma IEA Dictyostelium discoideum DDB_G0268620 R-DDI-8933446 https://reactome.org/PathwayBrowser/#/R-DDI-8933446 Active AKT phosphorylates DENND1A and DENND1B in response to insulin signaling IEA Dictyostelium discoideum DDB_G0268620 R-DDI-8948757 https://reactome.org/PathwayBrowser/#/R-DDI-8948757 AKT phosphorylates MKRN1 IEA Dictyostelium discoideum DDB_G0268620 R-DDI-9013145 https://reactome.org/PathwayBrowser/#/R-DDI-9013145 RAC1 binds effectors at the plasma membrane IEA Dictyostelium discoideum DDB_G0268620 R-DDI-9603279 https://reactome.org/PathwayBrowser/#/R-DDI-9603279 PIP3 recruits PDK1 and AKT to the membrane IEA Dictyostelium discoideum DDB_G0268620 R-DDI-9612509 https://reactome.org/PathwayBrowser/#/R-DDI-9612509 SGK phosphorylates SRF IEA Dictyostelium discoideum DDB_G0268620 R-DDI-9632858 https://reactome.org/PathwayBrowser/#/R-DDI-9632858 PRKCZ autophosphorylates downstream of estrogen stimulation IEA Dictyostelium discoideum DDB_G0268620 R-DDI-9841244 https://reactome.org/PathwayBrowser/#/R-DDI-9841244 Phosphorylation of AKT1 on serine-473 in response to reactive oxygen species IEA Dictyostelium discoideum DDB_G0268620 R-DDI-9860759 https://reactome.org/PathwayBrowser/#/R-DDI-9860759 p-T816-PKN2 phosphorylates AKT1 on serine-308 IEA Dictyostelium discoideum DDB_G0268620 R-DDI-9860785 https://reactome.org/PathwayBrowser/#/R-DDI-9860785 PDPK1 (PDK1) phosphorylates PKN2 on threonine-816 IEA Dictyostelium discoideum DDB_G0268620 R-DDI-9860792 https://reactome.org/PathwayBrowser/#/R-DDI-9860792 Phospho-AKT1 phosphorylates NOS3 (eNOS) on serine-1177 IEA Dictyostelium discoideum DDB_G0268620 R-DDI-9860800 https://reactome.org/PathwayBrowser/#/R-DDI-9860800 mTORC2 phosphorylates AKT1 on serine-473 IEA Dictyostelium discoideum DDB_G0268620 R-DDI-9860808 https://reactome.org/PathwayBrowser/#/R-DDI-9860808 p-T816-PKN2 phosphorylates NOS3 (eNOS) on serine-1179 IEA Dictyostelium discoideum DDB_G0268622 R-DDI-6798743 https://reactome.org/PathwayBrowser/#/R-DDI-6798743 Exocytosis of secretory granule membrane proteins IEA Dictyostelium discoideum DDB_G0268622 R-DDI-9014293 https://reactome.org/PathwayBrowser/#/R-DDI-9014293 RAC2 GDIs block activation of RAC2 IEA Dictyostelium discoideum DDB_G0268622 R-DDI-9014294 https://reactome.org/PathwayBrowser/#/R-DDI-9014294 RAC2 binds effectors at the plasma membrane IEA Dictyostelium discoideum DDB_G0268622 R-DDI-9014295 https://reactome.org/PathwayBrowser/#/R-DDI-9014295 RAC2 GAPs stimulate RAC2 GTPase activity IEA Dictyostelium discoideum DDB_G0268622 R-DDI-9014296 https://reactome.org/PathwayBrowser/#/R-DDI-9014296 RAC2 GEFs activate RAC2 IEA Dictyostelium discoideum DDB_G0268622 R-DDI-9014420 https://reactome.org/PathwayBrowser/#/R-DDI-9014420 RAC2 translocates to the phagocytic vesicle membrane IEA Dictyostelium discoideum DDB_G0268622 R-DDI-9014433 https://reactome.org/PathwayBrowser/#/R-DDI-9014433 RHOG GEFs activate RHOG IEA Dictyostelium discoideum DDB_G0268622 R-DDI-9014449 https://reactome.org/PathwayBrowser/#/R-DDI-9014449 RHOG binds effectors at the plasma membrane IEA Dictyostelium discoideum DDB_G0268622 R-DDI-9014454 https://reactome.org/PathwayBrowser/#/R-DDI-9014454 RHOG translocates to the ER membrane IEA Dictyostelium discoideum DDB_G0268622 R-DDI-9014456 https://reactome.org/PathwayBrowser/#/R-DDI-9014456 GDIs block activation of RHOG IEA Dictyostelium discoideum DDB_G0268622 R-DDI-9018754 https://reactome.org/PathwayBrowser/#/R-DDI-9018754 GDIs bind RHOH IEA Dictyostelium discoideum DDB_G0268622 R-DDI-9018756 https://reactome.org/PathwayBrowser/#/R-DDI-9018756 RHOH binds GTP IEA Dictyostelium discoideum DDB_G0268622 R-DDI-9018758 https://reactome.org/PathwayBrowser/#/R-DDI-9018758 RHOH binds effectors at the plasma membrane IEA Dictyostelium discoideum DDB_G0268622 R-DDI-9018774 https://reactome.org/PathwayBrowser/#/R-DDI-9018774 RHOBTB1 binds GTP IEA Dictyostelium discoideum DDB_G0268622 R-DDI-9018778 https://reactome.org/PathwayBrowser/#/R-DDI-9018778 RHOBTB1 binds interacting proteins at the endosome membrane IEA Dictyostelium discoideum DDB_G0268622 R-DDI-9018787 https://reactome.org/PathwayBrowser/#/R-DDI-9018787 RHOBTB2 binds interacting proteins at the endosome membrane IEA Dictyostelium discoideum DDB_G0268622 R-DDI-9714477 https://reactome.org/PathwayBrowser/#/R-DDI-9714477 RAC2 binds effectors at the mitochondrial outer membrane IEA Dictyostelium discoideum DDB_G0268622 R-DDI-9714480 https://reactome.org/PathwayBrowser/#/R-DDI-9714480 RAC2 translocates to the mitochondrial membrane IEA Dictyostelium discoideum DDB_G0268622 R-DDI-9714483 https://reactome.org/PathwayBrowser/#/R-DDI-9714483 RAC2 translocates to the ER membrane IEA Dictyostelium discoideum DDB_G0268628 R-DDI-6798748 https://reactome.org/PathwayBrowser/#/R-DDI-6798748 Exocytosis of secretory granule lumen proteins IEA Dictyostelium discoideum DDB_G0268628 R-DDI-6798749 https://reactome.org/PathwayBrowser/#/R-DDI-6798749 Exocytosis of specific granule lumen proteins IEA Dictyostelium discoideum DDB_G0268628 R-DDI-964958 https://reactome.org/PathwayBrowser/#/R-DDI-964958 2xPDXK:2xZn2+ phosphorylates PXA IEA Dictyostelium discoideum DDB_G0268628 R-DDI-964962 https://reactome.org/PathwayBrowser/#/R-DDI-964962 2xPDKX:2xZn2+ phosphorylates PDX IEA Dictyostelium discoideum DDB_G0268628 R-DDI-964970 https://reactome.org/PathwayBrowser/#/R-DDI-964970 2xPDXK:2xZn2+ phosphorylates PXL IEA Dictyostelium discoideum DDB_G0268630 R-DDI-351215 https://reactome.org/PathwayBrowser/#/R-DDI-351215 Putrescine + dc-Adenosyl methionine => Spermidine + 5'-methylthioadenosine IEA Dictyostelium discoideum DDB_G0268632 R-DDI-481007 https://reactome.org/PathwayBrowser/#/R-DDI-481007 Exocytosis of platelet alpha granule contents IEA Dictyostelium discoideum DDB_G0268632 R-DDI-6798745 https://reactome.org/PathwayBrowser/#/R-DDI-6798745 Exocytosis of tertiary granule lumen proteins IEA Dictyostelium discoideum DDB_G0268632 R-DDI-6798749 https://reactome.org/PathwayBrowser/#/R-DDI-6798749 Exocytosis of specific granule lumen proteins IEA Dictyostelium discoideum DDB_G0268632 R-DDI-6807875 https://reactome.org/PathwayBrowser/#/R-DDI-6807875 ARFGAP, cargo, v-SNAREs and p24 proteins bind nascent COPI complex IEA Dictyostelium discoideum DDB_G0268632 R-DDI-6807877 https://reactome.org/PathwayBrowser/#/R-DDI-6807877 ARFGAPs stimulate ARF GTPase activity IEA Dictyostelium discoideum DDB_G0268632 R-DDI-6809003 https://reactome.org/PathwayBrowser/#/R-DDI-6809003 ERGIC-to-Golgi vesicles bind dynein:dynactin IEA Dictyostelium discoideum DDB_G0268632 R-DDI-6809011 https://reactome.org/PathwayBrowser/#/R-DDI-6809011 cis-Golgi t-SNAREs bind YKT6 on tethered vesicle IEA Dictyostelium discoideum DDB_G0268632 R-DDI-9018766 https://reactome.org/PathwayBrowser/#/R-DDI-9018766 RHOU binds effectors at the plasma membrane IEA Dictyostelium discoideum DDB_G0268632 R-DDI-9018787 https://reactome.org/PathwayBrowser/#/R-DDI-9018787 RHOBTB2 binds interacting proteins at the endosome membrane IEA Dictyostelium discoideum DDB_G0268632 R-DDI-9018794 https://reactome.org/PathwayBrowser/#/R-DDI-9018794 RHOV binds effectors at the plasma membrane IEA Dictyostelium discoideum DDB_G0268634 R-DDI-111955 https://reactome.org/PathwayBrowser/#/R-DDI-111955 cAMP hydrolysis by Cam-PDE 1 IEA Dictyostelium discoideum DDB_G0268634 R-DDI-111956 https://reactome.org/PathwayBrowser/#/R-DDI-111956 Calmodulin activates Cam-PDE 1 IEA Dictyostelium discoideum DDB_G0268634 R-DDI-111962 https://reactome.org/PathwayBrowser/#/R-DDI-111962 PDE4A,C,D hydrolyse cAMP IEA Dictyostelium discoideum DDB_G0268634 R-DDI-162425 https://reactome.org/PathwayBrowser/#/R-DDI-162425 p-S295-PDE3B hydrolyses cAMP to AMP IEA Dictyostelium discoideum DDB_G0268634 R-DDI-418456 https://reactome.org/PathwayBrowser/#/R-DDI-418456 cGMP is degraded by PDEs IEA Dictyostelium discoideum DDB_G0268634 R-DDI-418553 https://reactome.org/PathwayBrowser/#/R-DDI-418553 cAMP degradation by Phosphodiesterases IEA Dictyostelium discoideum DDB_G0268634 R-DDI-9629675 https://reactome.org/PathwayBrowser/#/R-DDI-9629675 PDE3A hydrolyses cAMP to AMP IEA Dictyostelium discoideum DDB_G0268634 R-DDI-9629679 https://reactome.org/PathwayBrowser/#/R-DDI-9629679 PDE3A inhibitors bind PDE3A IEA Dictyostelium discoideum DDB_G0268634 R-DDI-9644869 https://reactome.org/PathwayBrowser/#/R-DDI-9644869 p-S54-PDE4B hydrolyses cAMP IEA Dictyostelium discoideum DDB_G0268634 R-DDI-9705507 https://reactome.org/PathwayBrowser/#/R-DDI-9705507 PDE3B hydrolyses cAMP to AMP IEA Dictyostelium discoideum DDB_G0268634 R-DDI-9708261 https://reactome.org/PathwayBrowser/#/R-DDI-9708261 PDE4A hydrolyses cAMP to AMP IEA Dictyostelium discoideum DDB_G0268634 R-DDI-9708275 https://reactome.org/PathwayBrowser/#/R-DDI-9708275 PDE4A binds PDE4A inhibitors IEA Dictyostelium discoideum DDB_G0268636 R-DDI-9793472 https://reactome.org/PathwayBrowser/#/R-DDI-9793472 RIPK3 binds p-S9-PRKN IEA Dictyostelium discoideum DDB_G0268636 R-DDI-9793485 https://reactome.org/PathwayBrowser/#/R-DDI-9793485 PRKN polyubiquitinates RIPK3 IEA Dictyostelium discoideum DDB_G0268638 R-DDI-1112538 https://reactome.org/PathwayBrowser/#/R-DDI-1112538 Phosphorylated STAT1, STAT3 form dimers IEA Dictyostelium discoideum DDB_G0268638 R-DDI-1112587 https://reactome.org/PathwayBrowser/#/R-DDI-1112587 STAT1 and STAT3 dimers translocate to the nucleus IEA Dictyostelium discoideum DDB_G0268638 R-DDI-1169406 https://reactome.org/PathwayBrowser/#/R-DDI-1169406 ISGylation of host proteins IEA Dictyostelium discoideum DDB_G0268638 R-DDI-3249370 https://reactome.org/PathwayBrowser/#/R-DDI-3249370 p-S407,Y641-STAT6 dimer migrates to the nucleus IEA Dictyostelium discoideum DDB_G0268638 R-DDI-3249372 https://reactome.org/PathwayBrowser/#/R-DDI-3249372 p-S407,Y641-STAT6 is dimerized IEA Dictyostelium discoideum DDB_G0268638 R-DDI-3249379 https://reactome.org/PathwayBrowser/#/R-DDI-3249379 p-S407-STAT6 is phosphorylated at Tyr641 IEA Dictyostelium discoideum DDB_G0268638 R-DDI-6784763 https://reactome.org/PathwayBrowser/#/R-DDI-6784763 p-Y705-STAT3 dimer translocates from cytosol to nucleoplasm IEA Dictyostelium discoideum DDB_G0268638 R-DDI-6784765 https://reactome.org/PathwayBrowser/#/R-DDI-6784765 p-Y705-STAT3 dimerizes IEA Dictyostelium discoideum DDB_G0268638 R-DDI-6786097 https://reactome.org/PathwayBrowser/#/R-DDI-6786097 p-Y705-STAT3, p-Y641-STAT6 dimerise IEA Dictyostelium discoideum DDB_G0268638 R-DDI-6786293 https://reactome.org/PathwayBrowser/#/R-DDI-6786293 p-Y705-STAT3 dimer, p-Y641-STAT6 dimer translocate to nucleus IEA Dictyostelium discoideum DDB_G0268638 R-DDI-6788622 https://reactome.org/PathwayBrowser/#/R-DDI-6788622 p-Y-STATs dimerize IEA Dictyostelium discoideum DDB_G0268638 R-DDI-6788623 https://reactome.org/PathwayBrowser/#/R-DDI-6788623 p-Y-STATs translocate to nucleus IEA Dictyostelium discoideum DDB_G0268638 R-DDI-6790038 https://reactome.org/PathwayBrowser/#/R-DDI-6790038 Expression of HSP90B1 IEA Dictyostelium discoideum DDB_G0268638 R-DDI-873917 https://reactome.org/PathwayBrowser/#/R-DDI-873917 Translocation of STAT1 dimer to nucleus IEA Dictyostelium discoideum DDB_G0268638 R-DDI-8950181 https://reactome.org/PathwayBrowser/#/R-DDI-8950181 Y693-STAT4 dimer translocates to the nucleus IEA Dictyostelium discoideum DDB_G0268638 R-DDI-8950522 https://reactome.org/PathwayBrowser/#/R-DDI-8950522 p-STAT1:p-STAT4 translocates to the nucleus IEA Dictyostelium discoideum DDB_G0268638 R-DDI-8950724 https://reactome.org/PathwayBrowser/#/R-DDI-8950724 p-Y705-STAT3:p-Y693-STAT4 translocates to the nucleus IEA Dictyostelium discoideum DDB_G0268638 R-DDI-8950733 https://reactome.org/PathwayBrowser/#/R-DDI-8950733 p-Y701-STAT1:p-Y705-STAT3 translocates to the nucleus IEA Dictyostelium discoideum DDB_G0268638 R-DDI-8950778 https://reactome.org/PathwayBrowser/#/R-DDI-8950778 p-Y693-STAT4 dimerizes IEA Dictyostelium discoideum DDB_G0268638 R-DDI-8950780 https://reactome.org/PathwayBrowser/#/R-DDI-8950780 p-Y705-STAT3 binds p-Y693-STAT4 IEA Dictyostelium discoideum DDB_G0268638 R-DDI-8950782 https://reactome.org/PathwayBrowser/#/R-DDI-8950782 p-STAT1 binds p-STAT3 IEA Dictyostelium discoideum DDB_G0268638 R-DDI-8983373 https://reactome.org/PathwayBrowser/#/R-DDI-8983373 p-Y-STAT3 binds p-STAT5 IEA Dictyostelium discoideum DDB_G0268638 R-DDI-8983379 https://reactome.org/PathwayBrowser/#/R-DDI-8983379 p-Y-STAT3:p-STAT5 translocates to the nucleus IEA Dictyostelium discoideum DDB_G0268638 R-DDI-8985943 https://reactome.org/PathwayBrowser/#/R-DDI-8985943 p-Y701-STAT1 dimerizes IEA Dictyostelium discoideum DDB_G0268638 R-DDI-8985950 https://reactome.org/PathwayBrowser/#/R-DDI-8985950 p-Y694-STAT5A, p-STAT5B dimerizes IEA Dictyostelium discoideum DDB_G0268638 R-DDI-8985966 https://reactome.org/PathwayBrowser/#/R-DDI-8985966 p-Y701-STAT1 binds p-Y705-STAT3 IEA Dictyostelium discoideum DDB_G0268638 R-DDI-8985981 https://reactome.org/PathwayBrowser/#/R-DDI-8985981 p-Y701-STAT1:p-Y705-STAT3 translocates from the cytosol to the nucleus IEA Dictyostelium discoideum DDB_G0268638 R-DDI-8985983 https://reactome.org/PathwayBrowser/#/R-DDI-8985983 p-Y701-STAT1 dimer translocates from the cytosol to the nucleus IEA Dictyostelium discoideum DDB_G0268638 R-DDI-8987007 https://reactome.org/PathwayBrowser/#/R-DDI-8987007 p-STAT1 dimerizes IEA Dictyostelium discoideum DDB_G0268638 R-DDI-8987052 https://reactome.org/PathwayBrowser/#/R-DDI-8987052 p-STAT3 dimer translocates from cytosol to nucleoplasm IEA Dictyostelium discoideum DDB_G0268638 R-DDI-8987214 https://reactome.org/PathwayBrowser/#/R-DDI-8987214 p-STAT3 dimerizes IEA Dictyostelium discoideum DDB_G0268638 R-DDI-8987218 https://reactome.org/PathwayBrowser/#/R-DDI-8987218 p-STAT1 dimer translocates from the cytosol to the nucleoplasm IEA Dictyostelium discoideum DDB_G0268638 R-DDI-9009072 https://reactome.org/PathwayBrowser/#/R-DDI-9009072 STAT3 phosphorylation IEA Dictyostelium discoideum DDB_G0268638 R-DDI-9701525 https://reactome.org/PathwayBrowser/#/R-DDI-9701525 p-Y705,S727-STAT3 dimerizes IEA Dictyostelium discoideum DDB_G0268638 R-DDI-9701529 https://reactome.org/PathwayBrowser/#/R-DDI-9701529 p-Y705, p-S727 STAT3 dimer translocates to the nucleus IEA Dictyostelium discoideum DDB_G0268638 R-DDI-9701565 https://reactome.org/PathwayBrowser/#/R-DDI-9701565 HDACs deacetylate p-STAT3 dimers IEA Dictyostelium discoideum DDB_G0268638 R-DDI-9710959 https://reactome.org/PathwayBrowser/#/R-DDI-9710959 p-STAT1 dimer binds KPNA1 IEA Dictyostelium discoideum DDB_G0268638 R-DDI-9865511 https://reactome.org/PathwayBrowser/#/R-DDI-9865511 Phosphorylation of STAT1 on tyrosine-701 is enhanced by p-S172-IKBKE IEA Dictyostelium discoideum DDB_G0268664 R-DDI-6784393 https://reactome.org/PathwayBrowser/#/R-DDI-6784393 PXLP-K279-GOT2 dimer transaminates 4-OH-L-glutamate to 4-hydroxy-2-oxoglutarate (HOG) IEA Dictyostelium discoideum DDB_G0268664 R-DDI-70596 https://reactome.org/PathwayBrowser/#/R-DDI-70596 GOT2 dimer deaminates L-Asp IEA Dictyostelium discoideum DDB_G0268664 R-DDI-70613 https://reactome.org/PathwayBrowser/#/R-DDI-70613 GOT2 transaminates OA and L-Glu IEA Dictyostelium discoideum DDB_G0268668 R-DDI-109639 https://reactome.org/PathwayBrowser/#/R-DDI-109639 Formation of the closed pre-initiation complex IEA Dictyostelium discoideum DDB_G0268668 R-DDI-111264 https://reactome.org/PathwayBrowser/#/R-DDI-111264 Addition of nucleotides between position +11 and +30 IEA Dictyostelium discoideum DDB_G0268668 R-DDI-112383 https://reactome.org/PathwayBrowser/#/R-DDI-112383 Hypophosphorylation of RNA Pol II CTD by FCP1P protein IEA Dictyostelium discoideum DDB_G0268668 R-DDI-113430 https://reactome.org/PathwayBrowser/#/R-DDI-113430 Extrusion of 5'-end of 30 nt long transcript through the pore in Pol II complex IEA Dictyostelium discoideum DDB_G0268668 R-DDI-5691000 https://reactome.org/PathwayBrowser/#/R-DDI-5691000 TFIIH binds GG-NER site to form a verification complex IEA Dictyostelium discoideum DDB_G0268668 R-DDI-6781818 https://reactome.org/PathwayBrowser/#/R-DDI-6781818 RNA Pol II initiates transcription from damaged DNA template IEA Dictyostelium discoideum DDB_G0268668 R-DDI-6781824 https://reactome.org/PathwayBrowser/#/R-DDI-6781824 Active RNA Pol II complex transcribes lesion-containing DNA template IEA Dictyostelium discoideum DDB_G0268668 R-DDI-6781833 https://reactome.org/PathwayBrowser/#/R-DDI-6781833 ERCC8 (CSA) binds stalled RNA Pol II IEA Dictyostelium discoideum DDB_G0268668 R-DDI-6781840 https://reactome.org/PathwayBrowser/#/R-DDI-6781840 ERCC6 binds stalled RNA Pol II IEA Dictyostelium discoideum DDB_G0268668 R-DDI-6781867 https://reactome.org/PathwayBrowser/#/R-DDI-6781867 ERCC8:DDB1:CUL4:RBX1 ubiquitinates ERCC6 and RNA Pol II IEA Dictyostelium discoideum DDB_G0268668 R-DDI-6782069 https://reactome.org/PathwayBrowser/#/R-DDI-6782069 UVSSA:USP7 deubiquitinates ERCC6 IEA Dictyostelium discoideum DDB_G0268668 R-DDI-6782131 https://reactome.org/PathwayBrowser/#/R-DDI-6782131 ERCC2-facilitated RNA Pol II backtracking in TC-NER IEA Dictyostelium discoideum DDB_G0268668 R-DDI-6782141 https://reactome.org/PathwayBrowser/#/R-DDI-6782141 Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in TC-NER IEA Dictyostelium discoideum DDB_G0268668 R-DDI-6782204 https://reactome.org/PathwayBrowser/#/R-DDI-6782204 5' incision of damaged DNA strand by ERCC1:ERCC4 in TC-NER IEA Dictyostelium discoideum DDB_G0268668 R-DDI-6782208 https://reactome.org/PathwayBrowser/#/R-DDI-6782208 Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in TC-NER IEA Dictyostelium discoideum DDB_G0268668 R-DDI-6782211 https://reactome.org/PathwayBrowser/#/R-DDI-6782211 DNA polymerases delta, epsilon or kappa bind the TC-NER site IEA Dictyostelium discoideum DDB_G0268668 R-DDI-6782227 https://reactome.org/PathwayBrowser/#/R-DDI-6782227 Ligation of newly synthesized repair patch to incised DNA in TC-NER IEA Dictyostelium discoideum DDB_G0268668 R-DDI-6797606 https://reactome.org/PathwayBrowser/#/R-DDI-6797606 CDK12 phosphorylates RNA Pol II CTD at DNA repair genes IEA Dictyostelium discoideum DDB_G0268668 R-DDI-6797616 https://reactome.org/PathwayBrowser/#/R-DDI-6797616 CCNK:CDK12 binds RNA Pol II at DNA repair genes IEA Dictyostelium discoideum DDB_G0268668 R-DDI-73769 https://reactome.org/PathwayBrowser/#/R-DDI-73769 Loss of Rrn3 from RNA Polymerase I promoter escape complex IEA Dictyostelium discoideum DDB_G0268668 R-DDI-73946 https://reactome.org/PathwayBrowser/#/R-DDI-73946 Abortive initiation after formation of the first phosphodiester bond IEA Dictyostelium discoideum DDB_G0268668 R-DDI-74986 https://reactome.org/PathwayBrowser/#/R-DDI-74986 Elongation of pre-rRNA transcript IEA Dictyostelium discoideum DDB_G0268668 R-DDI-75850 https://reactome.org/PathwayBrowser/#/R-DDI-75850 Addition of the third nucleotide on the nascent transcript IEA Dictyostelium discoideum DDB_G0268668 R-DDI-75856 https://reactome.org/PathwayBrowser/#/R-DDI-75856 Abortive Initiation Before Second Transition IEA Dictyostelium discoideum DDB_G0268668 R-DDI-75861 https://reactome.org/PathwayBrowser/#/R-DDI-75861 NTP Binds Active Site of RNA Polymerase II IEA Dictyostelium discoideum DDB_G0268668 R-DDI-75862 https://reactome.org/PathwayBrowser/#/R-DDI-75862 Fall Back to Closed Pre-initiation Complex IEA Dictyostelium discoideum DDB_G0268668 R-DDI-75864 https://reactome.org/PathwayBrowser/#/R-DDI-75864 Newly Formed Phosphodiester Bond Stabilized and PPi Released IEA Dictyostelium discoideum DDB_G0268668 R-DDI-75866 https://reactome.org/PathwayBrowser/#/R-DDI-75866 Nucleophillic Attack by 3'-hydroxyl Oxygen of nascent transcript on the Alpha Phosphate of NTP IEA Dictyostelium discoideum DDB_G0268668 R-DDI-75869 https://reactome.org/PathwayBrowser/#/R-DDI-75869 Addition of the fourth nucleotide on the Nascent Transcript: Second Transition IEA Dictyostelium discoideum DDB_G0268668 R-DDI-75873 https://reactome.org/PathwayBrowser/#/R-DDI-75873 Addition of Nucleotides 5 through 9 on the growing Transcript IEA Dictyostelium discoideum DDB_G0268668 R-DDI-75891 https://reactome.org/PathwayBrowser/#/R-DDI-75891 Abortive Initiation After Second Transition IEA Dictyostelium discoideum DDB_G0268668 R-DDI-75949 https://reactome.org/PathwayBrowser/#/R-DDI-75949 RNA Polymerase II Promoter Opening: First Transition IEA Dictyostelium discoideum DDB_G0268668 R-DDI-76576 https://reactome.org/PathwayBrowser/#/R-DDI-76576 Addition of nucleotides 10 and 11 on the growing transcript: Third Transition IEA Dictyostelium discoideum DDB_G0268668 R-DDI-77068 https://reactome.org/PathwayBrowser/#/R-DDI-77068 Activation of GT IEA Dictyostelium discoideum DDB_G0268668 R-DDI-77069 https://reactome.org/PathwayBrowser/#/R-DDI-77069 RNA Polymerase II CTD (phosphorylated) binds to CE IEA Dictyostelium discoideum DDB_G0268668 R-DDI-77071 https://reactome.org/PathwayBrowser/#/R-DDI-77071 Phosphorylation (Ser5) of RNA pol II CTD IEA Dictyostelium discoideum DDB_G0268668 R-DDI-77073 https://reactome.org/PathwayBrowser/#/R-DDI-77073 SPT5 subunit of Pol II binds the RNA triphosphatase (RTP) IEA Dictyostelium discoideum DDB_G0268668 R-DDI-77077 https://reactome.org/PathwayBrowser/#/R-DDI-77077 Capping complex formation IEA Dictyostelium discoideum DDB_G0268668 R-DDI-77078 https://reactome.org/PathwayBrowser/#/R-DDI-77078 Hydrolysis of the 5'-end of the nascent transcript by the capping enzyme IEA Dictyostelium discoideum DDB_G0268668 R-DDI-77081 https://reactome.org/PathwayBrowser/#/R-DDI-77081 Formation of the CE:GMP intermediate complex IEA Dictyostelium discoideum DDB_G0268668 R-DDI-77083 https://reactome.org/PathwayBrowser/#/R-DDI-77083 Transfer of GMP from the capping enzyme GT site to 5'-end of mRNA IEA Dictyostelium discoideum DDB_G0268668 R-DDI-77085 https://reactome.org/PathwayBrowser/#/R-DDI-77085 Dissociation of transcript with 5'-GMP from GT IEA Dictyostelium discoideum DDB_G0268668 R-DDI-77090 https://reactome.org/PathwayBrowser/#/R-DDI-77090 Methylation of GMP-cap by RNA Methyltransferase IEA Dictyostelium discoideum DDB_G0268668 R-DDI-9613494 https://reactome.org/PathwayBrowser/#/R-DDI-9613494 Unwinding of DNA for the Nascent Transcript: Second Transition IEA Dictyostelium discoideum DDB_G0268668 R-DDI-9613497 https://reactome.org/PathwayBrowser/#/R-DDI-9613497 Unwinding DNA for the nascent transcript IEA Dictyostelium discoideum DDB_G0268668 R-DDI-9684118 https://reactome.org/PathwayBrowser/#/R-DDI-9684118 ERCC3-facilitated RNA Pol II backtracking in TC-NER IEA Dictyostelium discoideum DDB_G0268678 R-DDI-113409 https://reactome.org/PathwayBrowser/#/R-DDI-113409 Abortive termination of early transcription elongation by DSIF:NELF IEA Dictyostelium discoideum DDB_G0268678 R-DDI-6797606 https://reactome.org/PathwayBrowser/#/R-DDI-6797606 CDK12 phosphorylates RNA Pol II CTD at DNA repair genes IEA Dictyostelium discoideum DDB_G0268678 R-DDI-6797616 https://reactome.org/PathwayBrowser/#/R-DDI-6797616 CCNK:CDK12 binds RNA Pol II at DNA repair genes IEA Dictyostelium discoideum DDB_G0268702 R-DDI-6807872 https://reactome.org/PathwayBrowser/#/R-DDI-6807872 Active ARF recruits coatomer IEA Dictyostelium discoideum DDB_G0268702 R-DDI-6807875 https://reactome.org/PathwayBrowser/#/R-DDI-6807875 ARFGAP, cargo, v-SNAREs and p24 proteins bind nascent COPI complex IEA Dictyostelium discoideum DDB_G0268702 R-DDI-6807877 https://reactome.org/PathwayBrowser/#/R-DDI-6807877 ARFGAPs stimulate ARF GTPase activity IEA Dictyostelium discoideum DDB_G0268702 R-DDI-6809003 https://reactome.org/PathwayBrowser/#/R-DDI-6809003 ERGIC-to-Golgi vesicles bind dynein:dynactin IEA Dictyostelium discoideum DDB_G0268702 R-DDI-6809011 https://reactome.org/PathwayBrowser/#/R-DDI-6809011 cis-Golgi t-SNAREs bind YKT6 on tethered vesicle IEA Dictyostelium discoideum DDB_G0268702 R-DDI-6811412 https://reactome.org/PathwayBrowser/#/R-DDI-6811412 Active ARF recruits coatomer to the Golgi IEA Dictyostelium discoideum DDB_G0268702 R-DDI-6811417 https://reactome.org/PathwayBrowser/#/R-DDI-6811417 ARFGAP, cargo, vSNARES and p24 proteins bind COPI vesicles at Golgi IEA Dictyostelium discoideum DDB_G0268702 R-DDI-6811418 https://reactome.org/PathwayBrowser/#/R-DDI-6811418 ARFGAPs stimulate ARF GTPase activity at the Golgi membrane IEA Dictyostelium discoideum DDB_G0268702 R-DDI-6811427 https://reactome.org/PathwayBrowser/#/R-DDI-6811427 COPI vesicle uncoating at the ER IEA Dictyostelium discoideum DDB_G0268706 R-DDI-6814555 https://reactome.org/PathwayBrowser/#/R-DDI-6814555 Integrator complex processes the 3' end of snRNA IEA Dictyostelium discoideum DDB_G0268706 R-DDI-6814559 https://reactome.org/PathwayBrowser/#/R-DDI-6814559 Pre-snRNA is elongated and capped with 7-methylguanosine IEA Dictyostelium discoideum DDB_G0268716 R-DDI-429860 https://reactome.org/PathwayBrowser/#/R-DDI-429860 DCP1-DCP2 complex decaps mRNA IEA Dictyostelium discoideum DDB_G0268716 R-DDI-429978 https://reactome.org/PathwayBrowser/#/R-DDI-429978 Lsm1-7 Complex binds deadenylated mRNA IEA Dictyostelium discoideum DDB_G0268740 R-DDI-6789310 https://reactome.org/PathwayBrowser/#/R-DDI-6789310 LIPs hydrolyse TG to DAG and RCOOH IEA Dictyostelium discoideum DDB_G0268754 R-DDI-964737 https://reactome.org/PathwayBrowser/#/R-DDI-964737 Progressive trimming of alpha-1,2-linked mannose residues from Man9GlcNAc2 to produce Man5GlcNAc2 IEA Dictyostelium discoideum DDB_G0268754 R-DDI-964825 https://reactome.org/PathwayBrowser/#/R-DDI-964825 Progressive trimming of alpha-1,2-linked mannose residues from Man8GlcNAc2 to produce Man5GlcNAc2 IEA Dictyostelium discoideum DDB_G0268754 R-DDI-964830 https://reactome.org/PathwayBrowser/#/R-DDI-964830 Progressive trimming of alpha-1,2-linked mannose residues from Man7GlcNAc2 to produce Man5GlcNAc2 IEA Dictyostelium discoideum DDB_G0268758 R-DDI-481007 https://reactome.org/PathwayBrowser/#/R-DDI-481007 Exocytosis of platelet alpha granule contents IEA Dictyostelium discoideum DDB_G0268760 R-DDI-8849748 https://reactome.org/PathwayBrowser/#/R-DDI-8849748 The COG complex binds RABs at the Golgi membrane IEA Dictyostelium discoideum DDB_G0268760 R-DDI-8870466 https://reactome.org/PathwayBrowser/#/R-DDI-8870466 RGGT:CHM binds RABs IEA Dictyostelium discoideum DDB_G0268760 R-DDI-8870469 https://reactome.org/PathwayBrowser/#/R-DDI-8870469 RGGT geranylgeranylates RAB proteins IEA Dictyostelium discoideum DDB_G0268774 R-DDI-9770236 https://reactome.org/PathwayBrowser/#/R-DDI-9770236 Formation of the Spliceosomal P complex and exon ligation IEA Dictyostelium discoideum DDB_G0268778 R-DDI-4754181 https://reactome.org/PathwayBrowser/#/R-DDI-4754181 KDM5A-D demethylate Me2K5-histone H3 IEA Dictyostelium discoideum DDB_G0268778 R-DDI-5661116 https://reactome.org/PathwayBrowser/#/R-DDI-5661116 KDM5A-D demethylate Me3K5-histone H3 IEA Dictyostelium discoideum DDB_G0268802 R-DDI-111879 https://reactome.org/PathwayBrowser/#/R-DDI-111879 PIP2 hydrolysis IEA Dictyostelium discoideum DDB_G0268802 R-DDI-112037 https://reactome.org/PathwayBrowser/#/R-DDI-112037 Inactivation of PLC beta IEA Dictyostelium discoideum DDB_G0268802 R-DDI-114688 https://reactome.org/PathwayBrowser/#/R-DDI-114688 PLC-beta hydrolyses PIP2 to DAG and IP3 IEA Dictyostelium discoideum DDB_G0268802 R-DDI-167415 https://reactome.org/PathwayBrowser/#/R-DDI-167415 G-protein alpha subunit is inactivated IEA Dictyostelium discoideum DDB_G0268802 R-DDI-170666 https://reactome.org/PathwayBrowser/#/R-DDI-170666 Adenylate cyclase increases the GTPase activity of G alpha-olf IEA Dictyostelium discoideum DDB_G0268802 R-DDI-170671 https://reactome.org/PathwayBrowser/#/R-DDI-170671 G alpha-olf:GTP binds to Gi alpha1:GTP:adenylate cyclase complex IEA Dictyostelium discoideum DDB_G0268802 R-DDI-170672 https://reactome.org/PathwayBrowser/#/R-DDI-170672 Galpha-olf:GTP binds to adenylate cyclase and activates it IEA Dictyostelium discoideum DDB_G0268802 R-DDI-170674 https://reactome.org/PathwayBrowser/#/R-DDI-170674 Dissociation of the Gi alpha:G olf complex IEA Dictyostelium discoideum DDB_G0268802 R-DDI-170676 https://reactome.org/PathwayBrowser/#/R-DDI-170676 Adenylate cyclase converts ATP into cyclic AMP IEA Dictyostelium discoideum DDB_G0268802 R-DDI-170677 https://reactome.org/PathwayBrowser/#/R-DDI-170677 The G alpha-olf:GDP:Adenylate cyclase complex dissociates IEA Dictyostelium discoideum DDB_G0268802 R-DDI-170685 https://reactome.org/PathwayBrowser/#/R-DDI-170685 Adenylaye cyclase increases the GTPase activity of G alpha-olf IEA Dictyostelium discoideum DDB_G0268802 R-DDI-170686 https://reactome.org/PathwayBrowser/#/R-DDI-170686 Adenylate cyclase increases the GTPase activity of Gi alpha IEA Dictyostelium discoideum DDB_G0268802 R-DDI-399998 https://reactome.org/PathwayBrowser/#/R-DDI-399998 Activated Phospholipase C beta-1 hydrolyzes 1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate IEA Dictyostelium discoideum DDB_G0268802 R-DDI-418574 https://reactome.org/PathwayBrowser/#/R-DDI-418574 G alpha (12/13) auto-inactivates by hydrolysing GTP to GDP IEA Dictyostelium discoideum DDB_G0268802 R-DDI-418582 https://reactome.org/PathwayBrowser/#/R-DDI-418582 G alpha (q) auto-inactivates by hydrolysing GTP to GDP IEA Dictyostelium discoideum DDB_G0268802 R-DDI-428941 https://reactome.org/PathwayBrowser/#/R-DDI-428941 P2Y purinoceptor 1 activates MAP kinase p38 alpha IEA Dictyostelium discoideum DDB_G0268802 R-DDI-8982017 https://reactome.org/PathwayBrowser/#/R-DDI-8982017 Active G alpha (q) binds RGS proteins IEA Dictyostelium discoideum DDB_G0268802 R-DDI-8982025 https://reactome.org/PathwayBrowser/#/R-DDI-8982025 G alpha (q) in G (q):RGS complex is inactivated IEA Dictyostelium discoideum DDB_G0268802 R-DDI-8982026 https://reactome.org/PathwayBrowser/#/R-DDI-8982026 G alpha (q):RGS dissociates to inactive G alpha (q) IEA Dictyostelium discoideum DDB_G0268802 R-DDI-9013143 https://reactome.org/PathwayBrowser/#/R-DDI-9013143 RAC1 GEFs activate RAC1 IEA Dictyostelium discoideum DDB_G0268802 R-DDI-9013159 https://reactome.org/PathwayBrowser/#/R-DDI-9013159 CDC42 GEFs activate CDC42 IEA Dictyostelium discoideum DDB_G0268802 R-DDI-9860796 https://reactome.org/PathwayBrowser/#/R-DDI-9860796 Phosphorylation of PDPK1 on serine-241 IEA Dictyostelium discoideum DDB_G0268802 R-DDI-9860800 https://reactome.org/PathwayBrowser/#/R-DDI-9860800 mTORC2 phosphorylates AKT1 on serine-473 IEA Dictyostelium discoideum DDB_G0268872 R-DDI-6781814 https://reactome.org/PathwayBrowser/#/R-DDI-6781814 USP19 deubiquitinates RNF123 IEA Dictyostelium discoideum DDB_G0268876 R-DDI-5672948 https://reactome.org/PathwayBrowser/#/R-DDI-5672948 MARK3 phosphorylates KSR1 IEA Dictyostelium discoideum DDB_G0268876 R-DDI-5674019 https://reactome.org/PathwayBrowser/#/R-DDI-5674019 BRAP binds KSR1:MARK3 IEA Dictyostelium discoideum DDB_G0268888 R-DDI-1011598 https://reactome.org/PathwayBrowser/#/R-DDI-1011598 DOCKs bind to RhoGEFs IEA Dictyostelium discoideum DDB_G0268888 R-DDI-9013143 https://reactome.org/PathwayBrowser/#/R-DDI-9013143 RAC1 GEFs activate RAC1 IEA Dictyostelium discoideum DDB_G0268888 R-DDI-9013159 https://reactome.org/PathwayBrowser/#/R-DDI-9013159 CDC42 GEFs activate CDC42 IEA Dictyostelium discoideum DDB_G0268888 R-DDI-9014296 https://reactome.org/PathwayBrowser/#/R-DDI-9014296 RAC2 GEFs activate RAC2 IEA Dictyostelium discoideum DDB_G0268888 R-DDI-9017491 https://reactome.org/PathwayBrowser/#/R-DDI-9017491 RHOJ GEFs activate RHOJ IEA Dictyostelium discoideum DDB_G0268888 R-DDI-9018804 https://reactome.org/PathwayBrowser/#/R-DDI-9018804 RAC3 GEFs activate RAC3 IEA Dictyostelium discoideum DDB_G0268898 R-DDI-6791222 https://reactome.org/PathwayBrowser/#/R-DDI-6791222 21S pre-rRNA is nucleolytically processed at site E (site2a) to yield 18SE pre-rRNA IEA Dictyostelium discoideum DDB_G0268898 R-DDI-6791227 https://reactome.org/PathwayBrowser/#/R-DDI-6791227 47S pre-rRNA is nucleolytically processed at A' (01,A1), site A0, and site 02 (site 6) to yield 45S pre-rRNA IEA Dictyostelium discoideum DDB_G0268910 R-DDI-6798739 https://reactome.org/PathwayBrowser/#/R-DDI-6798739 Exocytosis of azurophil granule membrane proteins IEA Dictyostelium discoideum DDB_G0268910 R-DDI-6798749 https://reactome.org/PathwayBrowser/#/R-DDI-6798749 Exocytosis of specific granule lumen proteins IEA Dictyostelium discoideum DDB_G0268910 R-DDI-6799350 https://reactome.org/PathwayBrowser/#/R-DDI-6799350 Exocytosis of specific granule membrane proteins IEA Dictyostelium discoideum DDB_G0268910 R-DDI-8849748 https://reactome.org/PathwayBrowser/#/R-DDI-8849748 The COG complex binds RABs at the Golgi membrane IEA Dictyostelium discoideum DDB_G0268910 R-DDI-8870466 https://reactome.org/PathwayBrowser/#/R-DDI-8870466 RGGT:CHM binds RABs IEA Dictyostelium discoideum DDB_G0268910 R-DDI-8870469 https://reactome.org/PathwayBrowser/#/R-DDI-8870469 RGGT geranylgeranylates RAB proteins IEA Dictyostelium discoideum DDB_G0268920 R-DDI-448955 https://reactome.org/PathwayBrowser/#/R-DDI-448955 Phosphorylation of MEF2 proteins by p38 IEA Dictyostelium discoideum DDB_G0268938 R-DDI-8852130 https://reactome.org/PathwayBrowser/#/R-DDI-8852130 UBA1 conjugates ubiquitin to nuclear E2 enzymes IEA Dictyostelium discoideum DDB_G0268938 R-DDI-983140 https://reactome.org/PathwayBrowser/#/R-DDI-983140 Transfer of Ub from E2 to substrate and release of E2 IEA Dictyostelium discoideum DDB_G0268938 R-DDI-983152 https://reactome.org/PathwayBrowser/#/R-DDI-983152 Transfer of ubiquitin from E1 to E2 IEA Dictyostelium discoideum DDB_G0268938 R-DDI-983156 https://reactome.org/PathwayBrowser/#/R-DDI-983156 Polyubiquitination of substrate IEA Dictyostelium discoideum DDB_G0268938 R-DDI-983157 https://reactome.org/PathwayBrowser/#/R-DDI-983157 Interaction of E3 with substrate and E2-Ub complex IEA Dictyostelium discoideum DDB_G0268964 R-DDI-6789310 https://reactome.org/PathwayBrowser/#/R-DDI-6789310 LIPs hydrolyse TG to DAG and RCOOH IEA Dictyostelium discoideum DDB_G0268966 R-DDI-6789310 https://reactome.org/PathwayBrowser/#/R-DDI-6789310 LIPs hydrolyse TG to DAG and RCOOH IEA Dictyostelium discoideum DDB_G0268992 R-DDI-141423 https://reactome.org/PathwayBrowser/#/R-DDI-141423 Binding of the MCC complex to the APC/C complex IEA Dictyostelium discoideum DDB_G0268992 R-DDI-174057 https://reactome.org/PathwayBrowser/#/R-DDI-174057 Multiubiquitination of APC/C-associated Cdh1 IEA Dictyostelium discoideum DDB_G0268992 R-DDI-174058 https://reactome.org/PathwayBrowser/#/R-DDI-174058 Degradation of multiubiquitinated Cdh1 IEA Dictyostelium discoideum DDB_G0268992 R-DDI-174070 https://reactome.org/PathwayBrowser/#/R-DDI-174070 Association of Cdh1 with the APC/C IEA Dictyostelium discoideum DDB_G0268992 R-DDI-174079 https://reactome.org/PathwayBrowser/#/R-DDI-174079 Phosphorylation of Cdh1 by Cyclin A:Cdk2 IEA Dictyostelium discoideum DDB_G0268992 R-DDI-174088 https://reactome.org/PathwayBrowser/#/R-DDI-174088 Association of cell cycle proteins with the APC/C:Cdh1 complex IEA Dictyostelium discoideum DDB_G0268992 R-DDI-174104 https://reactome.org/PathwayBrowser/#/R-DDI-174104 Ubiquitination of Cyclin A by APC/C:Cdc20 complex IEA Dictyostelium discoideum DDB_G0268992 R-DDI-174105 https://reactome.org/PathwayBrowser/#/R-DDI-174105 Degradation of multiubiquitinated cell cycle proteins IEA Dictyostelium discoideum DDB_G0268992 R-DDI-174119 https://reactome.org/PathwayBrowser/#/R-DDI-174119 Free APC/C phosphorylated by Plk1 IEA Dictyostelium discoideum DDB_G0268992 R-DDI-174139 https://reactome.org/PathwayBrowser/#/R-DDI-174139 Dissociation of phospho-Cdh1 from the APC/C complex IEA Dictyostelium discoideum DDB_G0268992 R-DDI-174144 https://reactome.org/PathwayBrowser/#/R-DDI-174144 Ubiquitination of Securin by phospho-APC/C:Cdc20 complex IEA Dictyostelium discoideum DDB_G0268992 R-DDI-174195 https://reactome.org/PathwayBrowser/#/R-DDI-174195 Ubiquitination of cell cycle proteins targeted by the APC/C:Cdh1complex IEA Dictyostelium discoideum DDB_G0268992 R-DDI-174202 https://reactome.org/PathwayBrowser/#/R-DDI-174202 Degradation of multiubiquitinated Securin IEA Dictyostelium discoideum DDB_G0268992 R-DDI-174224 https://reactome.org/PathwayBrowser/#/R-DDI-174224 Dissociation of Cdc20 from APC/C complex IEA Dictyostelium discoideum DDB_G0268992 R-DDI-174227 https://reactome.org/PathwayBrowser/#/R-DDI-174227 Ubiquitination of Cyclin B by phospho-APC/C:Cdc20 complex IEA Dictyostelium discoideum DDB_G0268992 R-DDI-174238 https://reactome.org/PathwayBrowser/#/R-DDI-174238 Activation of APC/C:Cdc20 by dissociation of Cdc20:phospho-APC/C from Cdc20:phospho-APC/C:Mad2:Bub3:BubR1 IEA Dictyostelium discoideum DDB_G0268992 R-DDI-179410 https://reactome.org/PathwayBrowser/#/R-DDI-179410 Association of Nek2A with MCC:APC/C IEA Dictyostelium discoideum DDB_G0268992 R-DDI-179417 https://reactome.org/PathwayBrowser/#/R-DDI-179417 Multiubiquitination of Nek2A IEA Dictyostelium discoideum DDB_G0268992 R-DDI-179421 https://reactome.org/PathwayBrowser/#/R-DDI-179421 Degradation of multiubiquitinated Nek2A IEA Dictyostelium discoideum DDB_G0268992 R-DDI-188191 https://reactome.org/PathwayBrowser/#/R-DDI-188191 APC/C:Cdh1-mediated degradation of Skp2 IEA Dictyostelium discoideum DDB_G0268992 R-DDI-3788705 https://reactome.org/PathwayBrowser/#/R-DDI-3788705 CDKN1A (p21) prevents phosphorylation of Cdh1 by Cyclin A:Cdk2 IEA Dictyostelium discoideum DDB_G0268992 R-DDI-3788724 https://reactome.org/PathwayBrowser/#/R-DDI-3788724 Cdh1:APC/C ubiquitinates EHMT1 and EHMT2 IEA Dictyostelium discoideum DDB_G0268992 R-DDI-69015 https://reactome.org/PathwayBrowser/#/R-DDI-69015 Cytoplasmic phosphorylated Cdc6 is ubiquitinated by the anaphase-promoting complex IEA Dictyostelium discoideum DDB_G0268992 R-DDI-9686969 https://reactome.org/PathwayBrowser/#/R-DDI-9686969 APC/C:Cdh1 polyubiquitinates SKP2 IEA Dictyostelium discoideum DDB_G0268992 R-DDI-983140 https://reactome.org/PathwayBrowser/#/R-DDI-983140 Transfer of Ub from E2 to substrate and release of E2 IEA Dictyostelium discoideum DDB_G0268992 R-DDI-983147 https://reactome.org/PathwayBrowser/#/R-DDI-983147 Release of E3 from polyubiquitinated substrate IEA Dictyostelium discoideum DDB_G0268992 R-DDI-983156 https://reactome.org/PathwayBrowser/#/R-DDI-983156 Polyubiquitination of substrate IEA Dictyostelium discoideum DDB_G0268992 R-DDI-983157 https://reactome.org/PathwayBrowser/#/R-DDI-983157 Interaction of E3 with substrate and E2-Ub complex IEA Dictyostelium discoideum DDB_G0268994 R-DDI-6799581 https://reactome.org/PathwayBrowser/#/R-DDI-6799581 MAN2B2 hydrolyses GlcNAc (Man)3 to GlcNAc:Man IEA Dictyostelium discoideum DDB_G0269006 R-DDI-72103 https://reactome.org/PathwayBrowser/#/R-DDI-72103 Formation of pre-mRNPs IEA Dictyostelium discoideum DDB_G0269006 R-DDI-9770236 https://reactome.org/PathwayBrowser/#/R-DDI-9770236 Formation of the Spliceosomal P complex and exon ligation IEA Dictyostelium discoideum DDB_G0269034 R-DDI-8954327 https://reactome.org/PathwayBrowser/#/R-DDI-8954327 UCKL1 phosphorylates urindine, cytidine IEA Dictyostelium discoideum DDB_G0269046 R-DDI-450971 https://reactome.org/PathwayBrowser/#/R-DDI-450971 NNT dimer transfers proton from NADPH to NAD+ IEA Dictyostelium discoideum DDB_G0269052 R-DDI-8854173 https://reactome.org/PathwayBrowser/#/R-DDI-8854173 TBC RabGAPs accelerate GTP hydrolysis by RAB35 IEA Dictyostelium discoideum DDB_G0269054 R-DDI-9770236 https://reactome.org/PathwayBrowser/#/R-DDI-9770236 Formation of the Spliceosomal P complex and exon ligation IEA Dictyostelium discoideum DDB_G0269062 R-DDI-8877475 https://reactome.org/PathwayBrowser/#/R-DDI-8877475 TRAPPC complexes exchange GTP for GDP on RAB1 IEA Dictyostelium discoideum DDB_G0269086 R-DDI-1482543 https://reactome.org/PathwayBrowser/#/R-DDI-1482543 2-MAG is hydrolyzed to fatty acid and glycerol by MGLL IEA Dictyostelium discoideum DDB_G0269086 R-DDI-426043 https://reactome.org/PathwayBrowser/#/R-DDI-426043 2-AG hydrolysis to arachidonate by MAGL IEA Dictyostelium discoideum DDB_G0269100 R-DDI-1169398 https://reactome.org/PathwayBrowser/#/R-DDI-1169398 ISGylation of host protein filamin B IEA Dictyostelium discoideum DDB_G0269100 R-DDI-430347 https://reactome.org/PathwayBrowser/#/R-DDI-430347 MigFilin associates with Filamin and F-actin IEA Dictyostelium discoideum DDB_G0269100 R-DDI-482772 https://reactome.org/PathwayBrowser/#/R-DDI-482772 Release of platelet cytosolic components IEA Dictyostelium discoideum DDB_G0269100 R-DDI-5669240 https://reactome.org/PathwayBrowser/#/R-DDI-5669240 FLNA binds PAK1 IEA Dictyostelium discoideum DDB_G0269100 R-DDI-5669250 https://reactome.org/PathwayBrowser/#/R-DDI-5669250 PAK1 phosphorylates FLNA IEA Dictyostelium discoideum DDB_G0269102 R-DDI-2029466 https://reactome.org/PathwayBrowser/#/R-DDI-2029466 (WASPs, WAVE):G-actin:ARP2/3 binds F-actin IEA Dictyostelium discoideum DDB_G0269102 R-DDI-2029473 https://reactome.org/PathwayBrowser/#/R-DDI-2029473 Branching and elongation of mother and daughter filaments IEA Dictyostelium discoideum DDB_G0269102 R-DDI-2197690 https://reactome.org/PathwayBrowser/#/R-DDI-2197690 Detachment of WASP/WAVE IEA Dictyostelium discoideum DDB_G0269104 R-DDI-111915 https://reactome.org/PathwayBrowser/#/R-DDI-111915 CAMK4 autophosphorylates IEA Dictyostelium discoideum DDB_G0269104 R-DDI-111930 https://reactome.org/PathwayBrowser/#/R-DDI-111930 Adenylate cyclase produces cAMP IEA Dictyostelium discoideum DDB_G0269104 R-DDI-111956 https://reactome.org/PathwayBrowser/#/R-DDI-111956 Calmodulin activates Cam-PDE 1 IEA Dictyostelium discoideum DDB_G0269104 R-DDI-1497784 https://reactome.org/PathwayBrowser/#/R-DDI-1497784 The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle IEA Dictyostelium discoideum DDB_G0269104 R-DDI-1497796 https://reactome.org/PathwayBrowser/#/R-DDI-1497796 BH2 binding can lead to eNOS uncoupling IEA Dictyostelium discoideum DDB_G0269104 R-DDI-1497810 https://reactome.org/PathwayBrowser/#/R-DDI-1497810 Uncoupled eNOS favours the formation of superoxide IEA Dictyostelium discoideum DDB_G0269104 R-DDI-1855153 https://reactome.org/PathwayBrowser/#/R-DDI-1855153 I(1,4,5)P3 is phosphorylated to I(1,3,4,5)P4 by ITPKA/B/C in the cytosol IEA Dictyostelium discoideum DDB_G0269104 R-DDI-202111 https://reactome.org/PathwayBrowser/#/R-DDI-202111 AKT1 phosphorylates eNOS IEA Dictyostelium discoideum DDB_G0269104 R-DDI-202127 https://reactome.org/PathwayBrowser/#/R-DDI-202127 eNOS synthesizes NO IEA Dictyostelium discoideum DDB_G0269104 R-DDI-202137 https://reactome.org/PathwayBrowser/#/R-DDI-202137 AKT1 binds eNOS complex via HSP90 IEA Dictyostelium discoideum DDB_G0269104 R-DDI-2730867 https://reactome.org/PathwayBrowser/#/R-DDI-2730867 Translocation of CaN:CaM:NFAT to nucleus IEA Dictyostelium discoideum DDB_G0269104 R-DDI-2730872 https://reactome.org/PathwayBrowser/#/R-DDI-2730872 Activation of Calcineurin IEA Dictyostelium discoideum DDB_G0269104 R-DDI-4551465 https://reactome.org/PathwayBrowser/#/R-DDI-4551465 Translocation of NFATC1:CaN:CaM to nucleus IEA Dictyostelium discoideum DDB_G0269104 R-DDI-482772 https://reactome.org/PathwayBrowser/#/R-DDI-482772 Release of platelet cytosolic components IEA Dictyostelium discoideum DDB_G0269104 R-DDI-5626507 https://reactome.org/PathwayBrowser/#/R-DDI-5626507 IQGAPs bind F-actin, which is inhibited by calmodulin IEA Dictyostelium discoideum DDB_G0269104 R-DDI-5626549 https://reactome.org/PathwayBrowser/#/R-DDI-5626549 IQGAPs bind CALM1 IEA Dictyostelium discoideum DDB_G0269104 R-DDI-6800434 https://reactome.org/PathwayBrowser/#/R-DDI-6800434 Exocytosis of ficolin-rich granule lumen proteins IEA Dictyostelium discoideum DDB_G0269104 R-DDI-9619376 https://reactome.org/PathwayBrowser/#/R-DDI-9619376 CAMK1 binds calmodulin IEA Dictyostelium discoideum DDB_G0269118 R-DDI-9837978 https://reactome.org/PathwayBrowser/#/R-DDI-9837978 LONP1 binds mitochondrial inner membrane proteins IEA Dictyostelium discoideum DDB_G0269118 R-DDI-9838004 https://reactome.org/PathwayBrowser/#/R-DDI-9838004 LONP1 degrades mitochondrial inner membrane proteins IEA Dictyostelium discoideum DDB_G0269122 R-DDI-1614567 https://reactome.org/PathwayBrowser/#/R-DDI-1614567 Excess homocysteine yields homolanthionine and H2S IEA Dictyostelium discoideum DDB_G0269122 R-DDI-1614583 https://reactome.org/PathwayBrowser/#/R-DDI-1614583 PXLP-K212-CTH cleaves L-Cystathionine IEA Dictyostelium discoideum DDB_G0269122 R-DDI-1614591 https://reactome.org/PathwayBrowser/#/R-DDI-1614591 Excess cysteine yields lanthionine and H2S IEA Dictyostelium discoideum DDB_G0269122 R-DDI-1614614 https://reactome.org/PathwayBrowser/#/R-DDI-1614614 Cysteine is degraded to serine and H2S IEA Dictyostelium discoideum DDB_G0269122 R-DDI-1614631 https://reactome.org/PathwayBrowser/#/R-DDI-1614631 Homocysteine is degraded to oxobutanoate and H2S IEA Dictyostelium discoideum DDB_G0269134 R-DDI-156913 https://reactome.org/PathwayBrowser/#/R-DDI-156913 Regeneration of eEF1A:GTP by eEF1B activity IEA Dictyostelium discoideum DDB_G0269134 R-DDI-3371591 https://reactome.org/PathwayBrowser/#/R-DDI-3371591 Trimerization of cytosolic HSF1 IEA Dictyostelium discoideum DDB_G0269134 R-DDI-6798748 https://reactome.org/PathwayBrowser/#/R-DDI-6798748 Exocytosis of secretory granule lumen proteins IEA Dictyostelium discoideum DDB_G0269134 R-DDI-6800434 https://reactome.org/PathwayBrowser/#/R-DDI-6800434 Exocytosis of ficolin-rich granule lumen proteins IEA Dictyostelium discoideum DDB_G0269134 R-DDI-8931974 https://reactome.org/PathwayBrowser/#/R-DDI-8931974 N6AMT2 transfers 3xCH3 from 3xAdoMet to EEF1A IEA Dictyostelium discoideum DDB_G0269134 R-DDI-8932413 https://reactome.org/PathwayBrowser/#/R-DDI-8932413 METTL10 transfers 3xCH3 from 3xAdoMet to EEF1A1 IEA Dictyostelium discoideum DDB_G0269136 R-DDI-156913 https://reactome.org/PathwayBrowser/#/R-DDI-156913 Regeneration of eEF1A:GTP by eEF1B activity IEA Dictyostelium discoideum DDB_G0269136 R-DDI-3371591 https://reactome.org/PathwayBrowser/#/R-DDI-3371591 Trimerization of cytosolic HSF1 IEA Dictyostelium discoideum DDB_G0269136 R-DDI-6798748 https://reactome.org/PathwayBrowser/#/R-DDI-6798748 Exocytosis of secretory granule lumen proteins IEA Dictyostelium discoideum DDB_G0269136 R-DDI-6800434 https://reactome.org/PathwayBrowser/#/R-DDI-6800434 Exocytosis of ficolin-rich granule lumen proteins IEA Dictyostelium discoideum DDB_G0269136 R-DDI-8931974 https://reactome.org/PathwayBrowser/#/R-DDI-8931974 N6AMT2 transfers 3xCH3 from 3xAdoMet to EEF1A IEA Dictyostelium discoideum DDB_G0269136 R-DDI-8932413 https://reactome.org/PathwayBrowser/#/R-DDI-8932413 METTL10 transfers 3xCH3 from 3xAdoMet to EEF1A1 IEA Dictyostelium discoideum DDB_G0269138 R-DDI-3371527 https://reactome.org/PathwayBrowser/#/R-DDI-3371527 HSF1 trimer translocates to the nucleus IEA Dictyostelium discoideum DDB_G0269138 R-DDI-4793925 https://reactome.org/PathwayBrowser/#/R-DDI-4793925 p-S303,307-HSF1 binds YWHAE (14-3-3) IEA Dictyostelium discoideum DDB_G0269138 R-DDI-5632732 https://reactome.org/PathwayBrowser/#/R-DDI-5632732 p-S939,T1462-TSC2 binding to 14-3-3 dimer is negatively regulated by DDIT4 IEA Dictyostelium discoideum DDB_G0269138 R-DDI-75016 https://reactome.org/PathwayBrowser/#/R-DDI-75016 Association of p-S216-CDC25C with 14-3-3 proteins IEA Dictyostelium discoideum DDB_G0269138 R-DDI-8877612 https://reactome.org/PathwayBrowser/#/R-DDI-8877612 DENND1s exchange GTP for GDP on RAB35 IEA Dictyostelium discoideum DDB_G0269138 R-DDI-8933452 https://reactome.org/PathwayBrowser/#/R-DDI-8933452 YWHAE dimer binds phosphorylated DENND1 proteins IEA Dictyostelium discoideum DDB_G0269140 R-DDI-5626469 https://reactome.org/PathwayBrowser/#/R-DDI-5626469 GTP-bound RAC1 and CDC42 bind IQGAPs IEA Dictyostelium discoideum DDB_G0269140 R-DDI-5626507 https://reactome.org/PathwayBrowser/#/R-DDI-5626507 IQGAPs bind F-actin, which is inhibited by calmodulin IEA Dictyostelium discoideum DDB_G0269140 R-DDI-5626549 https://reactome.org/PathwayBrowser/#/R-DDI-5626549 IQGAPs bind CALM1 IEA Dictyostelium discoideum DDB_G0269140 R-DDI-5672329 https://reactome.org/PathwayBrowser/#/R-DDI-5672329 IQGAP1 binds CLIP1 and microtubules IEA Dictyostelium discoideum DDB_G0269140 R-DDI-6798743 https://reactome.org/PathwayBrowser/#/R-DDI-6798743 Exocytosis of secretory granule membrane proteins IEA Dictyostelium discoideum DDB_G0269140 R-DDI-9013145 https://reactome.org/PathwayBrowser/#/R-DDI-9013145 RAC1 binds effectors at the plasma membrane IEA Dictyostelium discoideum DDB_G0269140 R-DDI-9014294 https://reactome.org/PathwayBrowser/#/R-DDI-9014294 RAC2 binds effectors at the plasma membrane IEA Dictyostelium discoideum DDB_G0269140 R-DDI-9018746 https://reactome.org/PathwayBrowser/#/R-DDI-9018746 RHOQ binds effectors at the plasma membrane IEA Dictyostelium discoideum DDB_G0269140 R-DDI-9018766 https://reactome.org/PathwayBrowser/#/R-DDI-9018766 RHOU binds effectors at the plasma membrane IEA Dictyostelium discoideum DDB_G0269140 R-DDI-9018794 https://reactome.org/PathwayBrowser/#/R-DDI-9018794 RHOV binds effectors at the plasma membrane IEA Dictyostelium discoideum DDB_G0269142 R-DDI-191352 https://reactome.org/PathwayBrowser/#/R-DDI-191352 HMGCR dimer reduces bHMG-CoA to MVA IEA Dictyostelium discoideum DDB_G0269142 R-DDI-9705584 https://reactome.org/PathwayBrowser/#/R-DDI-9705584 HMGCR dimer binds statins IEA Dictyostelium discoideum DDB_G0269144 R-DDI-3371422 https://reactome.org/PathwayBrowser/#/R-DDI-3371422 ATP hydrolysis by HSP70 IEA Dictyostelium discoideum DDB_G0269144 R-DDI-3371503 https://reactome.org/PathwayBrowser/#/R-DDI-3371503 STIP1(HOP) binds HSP90 and HSP70:HSP40:nascent protein IEA Dictyostelium discoideum DDB_G0269144 R-DDI-3371590 https://reactome.org/PathwayBrowser/#/R-DDI-3371590 HSP70 binds to HSP40:nascent protein IEA Dictyostelium discoideum DDB_G0269144 R-DDI-450580 https://reactome.org/PathwayBrowser/#/R-DDI-450580 AUF1 (hnRNP D0) is ubiquitinylated IEA Dictyostelium discoideum DDB_G0269144 R-DDI-5082356 https://reactome.org/PathwayBrowser/#/R-DDI-5082356 HSF1-mediated gene expression IEA Dictyostelium discoideum DDB_G0269144 R-DDI-5251942 https://reactome.org/PathwayBrowser/#/R-DDI-5251942 Hikeshi binds HSP70s:ATP IEA Dictyostelium discoideum DDB_G0269144 R-DDI-5251955 https://reactome.org/PathwayBrowser/#/R-DDI-5251955 HSP40s activate intrinsic ATPase activity of HSP70s in the nucleoplasm IEA Dictyostelium discoideum DDB_G0269144 R-DDI-5251959 https://reactome.org/PathwayBrowser/#/R-DDI-5251959 HSP40s activate intrinsic ATPase activity of HSP70s in the cytosol IEA Dictyostelium discoideum DDB_G0269144 R-DDI-5252079 https://reactome.org/PathwayBrowser/#/R-DDI-5252079 HSP110s exchange ATP for ADP on HSP70s:ADP IEA Dictyostelium discoideum DDB_G0269144 R-DDI-5618107 https://reactome.org/PathwayBrowser/#/R-DDI-5618107 ATP binding to HSP90 triggers conformation change IEA Dictyostelium discoideum DDB_G0269144 R-DDI-6798748 https://reactome.org/PathwayBrowser/#/R-DDI-6798748 Exocytosis of secretory granule lumen proteins IEA Dictyostelium discoideum DDB_G0269144 R-DDI-6800434 https://reactome.org/PathwayBrowser/#/R-DDI-6800434 Exocytosis of ficolin-rich granule lumen proteins IEA Dictyostelium discoideum DDB_G0269144 R-DDI-8932221 https://reactome.org/PathwayBrowser/#/R-DDI-8932221 METTL21A transfers 3xCH3 from 3xAdoMet to HSPA8 IEA Dictyostelium discoideum DDB_G0269144 R-DDI-9770236 https://reactome.org/PathwayBrowser/#/R-DDI-9770236 Formation of the Spliceosomal P complex and exon ligation IEA Dictyostelium discoideum DDB_G0269144 R-DDI-9857076 https://reactome.org/PathwayBrowser/#/R-DDI-9857076 Oxidized DNAJA1 binds HSPA1A,B (HSP70) displacing HSF1 IEA Dictyostelium discoideum DDB_G0269146 R-DDI-156823 https://reactome.org/PathwayBrowser/#/R-DDI-156823 Association of phospho-L13a with GAIT element of Ceruloplasmin mRNA IEA Dictyostelium discoideum DDB_G0269146 R-DDI-1678842 https://reactome.org/PathwayBrowser/#/R-DDI-1678842 Competitive inhibition of translation initiation by ISGylated 4EHP IEA Dictyostelium discoideum DDB_G0269146 R-DDI-72621 https://reactome.org/PathwayBrowser/#/R-DDI-72621 Ribosomal scanning IEA Dictyostelium discoideum DDB_G0269146 R-DDI-72631 https://reactome.org/PathwayBrowser/#/R-DDI-72631 Formation of the cap-binding eIF4F complex IEA Dictyostelium discoideum DDB_G0269146 R-DDI-72697 https://reactome.org/PathwayBrowser/#/R-DDI-72697 Start codon recognition IEA Dictyostelium discoideum DDB_G0269148 R-DDI-266072 https://reactome.org/PathwayBrowser/#/R-DDI-266072 LTA4 is hydolysed to LTB4 by LTA4H IEA Dictyostelium discoideum DDB_G0269148 R-DDI-6798745 https://reactome.org/PathwayBrowser/#/R-DDI-6798745 Exocytosis of tertiary granule lumen proteins IEA Dictyostelium discoideum DDB_G0269148 R-DDI-6800434 https://reactome.org/PathwayBrowser/#/R-DDI-6800434 Exocytosis of ficolin-rich granule lumen proteins IEA Dictyostelium discoideum DDB_G0269148 R-DDI-9018862 https://reactome.org/PathwayBrowser/#/R-DDI-9018862 LTA4H:Zn2+ hydrolyses 5S,6S-epoxy-18(S)-HEPE to 18(S)-RvE1 IEA Dictyostelium discoideum DDB_G0269148 R-DDI-9018877 https://reactome.org/PathwayBrowser/#/R-DDI-9018877 LTA4H:Zn2+ hydrolyses 5S,6S-epoxy-18(R)-HEPE to 18(R)-RvE1 IEA Dictyostelium discoideum DDB_G0269148 R-DDI-9020252 https://reactome.org/PathwayBrowser/#/R-DDI-9020252 LTA4H:Zn2+ hydrolyses 7S(8)-epoxy-17(R)-HDHA to AT-RvD1 or AT-RvD2 IEA Dictyostelium discoideum DDB_G0269148 R-DDI-9020253 https://reactome.org/PathwayBrowser/#/R-DDI-9020253 LTA4H:Zn2+ hydrolyses 4S(5)-epoxy-17(S)-HDHA to RvD3 or RvD4 IEA Dictyostelium discoideum DDB_G0269148 R-DDI-9020257 https://reactome.org/PathwayBrowser/#/R-DDI-9020257 LTA4H:Zn2+ hydrolyses 17R(16)-epoxy-DHA to AT-(N)PD1 IEA Dictyostelium discoideum DDB_G0269148 R-DDI-9020258 https://reactome.org/PathwayBrowser/#/R-DDI-9020258 LTA4H:Zn2+ hydrolyses 7S(8)-epoxy-17(S)-HDHA to RvD1 or RvD2 IEA Dictyostelium discoideum DDB_G0269148 R-DDI-9020270 https://reactome.org/PathwayBrowser/#/R-DDI-9020270 LTA4H:Zn2+ hydrolyses 4S(5)-epoxy-17(R)-HDHA to AT-RvD3 or AT-RvD4 IEA Dictyostelium discoideum DDB_G0269148 R-DDI-9024890 https://reactome.org/PathwayBrowser/#/R-DDI-9024890 LTA4H:Zn2+ hydrolyses 16S,17S-epoxy-DHA to (N)PD1 IEA Dictyostelium discoideum DDB_G0269156 R-DDI-6798748 https://reactome.org/PathwayBrowser/#/R-DDI-6798748 Exocytosis of secretory granule lumen proteins IEA Dictyostelium discoideum DDB_G0269156 R-DDI-6800434 https://reactome.org/PathwayBrowser/#/R-DDI-6800434 Exocytosis of ficolin-rich granule lumen proteins IEA Dictyostelium discoideum DDB_G0269158 R-DDI-265456 https://reactome.org/PathwayBrowser/#/R-DDI-265456 NPC1L1 binds ezetimibe IEA Dictyostelium discoideum DDB_G0269160 R-DDI-482772 https://reactome.org/PathwayBrowser/#/R-DDI-482772 Release of platelet cytosolic components IEA Dictyostelium discoideum DDB_G0269160 R-DDI-6798751 https://reactome.org/PathwayBrowser/#/R-DDI-6798751 Exocytosis of azurophil granule lumen proteins IEA Dictyostelium discoideum DDB_G0269162 R-DDI-5665868 https://reactome.org/PathwayBrowser/#/R-DDI-5665868 AMPK (complex) phosphorylates ULK1 (complex) IEA Dictyostelium discoideum DDB_G0269162 R-DDI-5672008 https://reactome.org/PathwayBrowser/#/R-DDI-5672008 Thr-180 of ULK1 is phosphorylated IEA Dictyostelium discoideum DDB_G0269162 R-DDI-5672010 https://reactome.org/PathwayBrowser/#/R-DDI-5672010 Active MTORC1 phosphorylates ULK1 IEA Dictyostelium discoideum DDB_G0269162 R-DDI-5672011 https://reactome.org/PathwayBrowser/#/R-DDI-5672011 p-AMPK:AMP binds the ULK complex IEA Dictyostelium discoideum DDB_G0269162 R-DDI-5672817 https://reactome.org/PathwayBrowser/#/R-DDI-5672817 Active MTORC1 binds the ULK1 complex IEA Dictyostelium discoideum DDB_G0269162 R-DDI-5673768 https://reactome.org/PathwayBrowser/#/R-DDI-5673768 p-AMPK:AMP phosphorylates Raptor in the MTORC1 complex IEA Dictyostelium discoideum DDB_G0269162 R-DDI-5675790 https://reactome.org/PathwayBrowser/#/R-DDI-5675790 MTORC1 dissociates from ULK complex IEA Dictyostelium discoideum DDB_G0269162 R-DDI-5675868 https://reactome.org/PathwayBrowser/#/R-DDI-5675868 ULK1 phosphorylates ATG13 and RB1CC1 IEA Dictyostelium discoideum DDB_G0269162 R-DDI-5679205 https://reactome.org/PathwayBrowser/#/R-DDI-5679205 ULK1 phosphorylates Beclin-1 IEA Dictyostelium discoideum DDB_G0269162 R-DDI-5679239 https://reactome.org/PathwayBrowser/#/R-DDI-5679239 ULK complex translocates to the ER IEA Dictyostelium discoideum DDB_G0269162 R-DDI-5683925 https://reactome.org/PathwayBrowser/#/R-DDI-5683925 ULK1 is dephosphorylated IEA Dictyostelium discoideum DDB_G0269166 R-DDI-389788 https://reactome.org/PathwayBrowser/#/R-DDI-389788 Activation of PAKs by RAC1 and CDC42 IEA Dictyostelium discoideum DDB_G0269166 R-DDI-5627775 https://reactome.org/PathwayBrowser/#/R-DDI-5627775 Autophosphorylation of PAK1,2,3 IEA Dictyostelium discoideum DDB_G0269166 R-DDI-5668932 https://reactome.org/PathwayBrowser/#/R-DDI-5668932 PAK2 phosphorylates myosin regulatory light chain (MRLC) IEA Dictyostelium discoideum DDB_G0269166 R-DDI-5687086 https://reactome.org/PathwayBrowser/#/R-DDI-5687086 PAK1,2,3 phosphorylates MAPK6,4 IEA Dictyostelium discoideum DDB_G0269166 R-DDI-8981926 https://reactome.org/PathwayBrowser/#/R-DDI-8981926 RAC1 and CDC42 activate PAK3 IEA Dictyostelium discoideum DDB_G0269166 R-DDI-8981931 https://reactome.org/PathwayBrowser/#/R-DDI-8981931 RAC1 and CDC42 activate PAK2 IEA Dictyostelium discoideum DDB_G0269166 R-DDI-9013145 https://reactome.org/PathwayBrowser/#/R-DDI-9013145 RAC1 binds effectors at the plasma membrane IEA Dictyostelium discoideum DDB_G0269166 R-DDI-9014294 https://reactome.org/PathwayBrowser/#/R-DDI-9014294 RAC2 binds effectors at the plasma membrane IEA Dictyostelium discoideum DDB_G0269166 R-DDI-9014449 https://reactome.org/PathwayBrowser/#/R-DDI-9014449 RHOG binds effectors at the plasma membrane IEA Dictyostelium discoideum DDB_G0269166 R-DDI-9018746 https://reactome.org/PathwayBrowser/#/R-DDI-9018746 RHOQ binds effectors at the plasma membrane IEA Dictyostelium discoideum DDB_G0269166 R-DDI-9018758 https://reactome.org/PathwayBrowser/#/R-DDI-9018758 RHOH binds effectors at the plasma membrane IEA Dictyostelium discoideum DDB_G0269166 R-DDI-9018766 https://reactome.org/PathwayBrowser/#/R-DDI-9018766 RHOU binds effectors at the plasma membrane IEA Dictyostelium discoideum DDB_G0269166 R-DDI-9018794 https://reactome.org/PathwayBrowser/#/R-DDI-9018794 RHOV binds effectors at the plasma membrane IEA Dictyostelium discoideum DDB_G0269166 R-DDI-9018808 https://reactome.org/PathwayBrowser/#/R-DDI-9018808 RAC3 binds effectors at the plasma membrane IEA Dictyostelium discoideum DDB_G0269168 R-DDI-3247836 https://reactome.org/PathwayBrowser/#/R-DDI-3247836 Retromer recycles WLS to the Golgi IEA Dictyostelium discoideum DDB_G0269174 R-DDI-6798739 https://reactome.org/PathwayBrowser/#/R-DDI-6798739 Exocytosis of azurophil granule membrane proteins IEA Dictyostelium discoideum DDB_G0269174 R-DDI-6799350 https://reactome.org/PathwayBrowser/#/R-DDI-6799350 Exocytosis of specific granule membrane proteins IEA Dictyostelium discoideum DDB_G0269174 R-DDI-8847887 https://reactome.org/PathwayBrowser/#/R-DDI-8847887 RAB33B:GTP binds RIC1:RGP1 IEA Dictyostelium discoideum DDB_G0269174 R-DDI-8854612 https://reactome.org/PathwayBrowser/#/R-DDI-8854612 TBC1D25 accelerates GTP hydrolysis by RAB33B IEA Dictyostelium discoideum DDB_G0269174 R-DDI-8870466 https://reactome.org/PathwayBrowser/#/R-DDI-8870466 RGGT:CHM binds RABs IEA Dictyostelium discoideum DDB_G0269174 R-DDI-8870469 https://reactome.org/PathwayBrowser/#/R-DDI-8870469 RGGT geranylgeranylates RAB proteins IEA Dictyostelium discoideum DDB_G0269176 R-DDI-6798743 https://reactome.org/PathwayBrowser/#/R-DDI-6798743 Exocytosis of secretory granule membrane proteins IEA Dictyostelium discoideum DDB_G0269176 R-DDI-9014293 https://reactome.org/PathwayBrowser/#/R-DDI-9014293 RAC2 GDIs block activation of RAC2 IEA Dictyostelium discoideum DDB_G0269176 R-DDI-9014294 https://reactome.org/PathwayBrowser/#/R-DDI-9014294 RAC2 binds effectors at the plasma membrane IEA Dictyostelium discoideum DDB_G0269176 R-DDI-9014295 https://reactome.org/PathwayBrowser/#/R-DDI-9014295 RAC2 GAPs stimulate RAC2 GTPase activity IEA Dictyostelium discoideum DDB_G0269176 R-DDI-9014296 https://reactome.org/PathwayBrowser/#/R-DDI-9014296 RAC2 GEFs activate RAC2 IEA Dictyostelium discoideum DDB_G0269176 R-DDI-9014420 https://reactome.org/PathwayBrowser/#/R-DDI-9014420 RAC2 translocates to the phagocytic vesicle membrane IEA Dictyostelium discoideum DDB_G0269176 R-DDI-9014433 https://reactome.org/PathwayBrowser/#/R-DDI-9014433 RHOG GEFs activate RHOG IEA Dictyostelium discoideum DDB_G0269176 R-DDI-9014449 https://reactome.org/PathwayBrowser/#/R-DDI-9014449 RHOG binds effectors at the plasma membrane IEA Dictyostelium discoideum DDB_G0269176 R-DDI-9014454 https://reactome.org/PathwayBrowser/#/R-DDI-9014454 RHOG translocates to the ER membrane IEA Dictyostelium discoideum DDB_G0269176 R-DDI-9014456 https://reactome.org/PathwayBrowser/#/R-DDI-9014456 GDIs block activation of RHOG IEA Dictyostelium discoideum DDB_G0269176 R-DDI-9018754 https://reactome.org/PathwayBrowser/#/R-DDI-9018754 GDIs bind RHOH IEA Dictyostelium discoideum DDB_G0269176 R-DDI-9018756 https://reactome.org/PathwayBrowser/#/R-DDI-9018756 RHOH binds GTP IEA Dictyostelium discoideum DDB_G0269176 R-DDI-9018758 https://reactome.org/PathwayBrowser/#/R-DDI-9018758 RHOH binds effectors at the plasma membrane IEA Dictyostelium discoideum DDB_G0269176 R-DDI-9018774 https://reactome.org/PathwayBrowser/#/R-DDI-9018774 RHOBTB1 binds GTP IEA Dictyostelium discoideum DDB_G0269176 R-DDI-9018778 https://reactome.org/PathwayBrowser/#/R-DDI-9018778 RHOBTB1 binds interacting proteins at the endosome membrane IEA Dictyostelium discoideum DDB_G0269176 R-DDI-9018787 https://reactome.org/PathwayBrowser/#/R-DDI-9018787 RHOBTB2 binds interacting proteins at the endosome membrane IEA Dictyostelium discoideum DDB_G0269176 R-DDI-9714477 https://reactome.org/PathwayBrowser/#/R-DDI-9714477 RAC2 binds effectors at the mitochondrial outer membrane IEA Dictyostelium discoideum DDB_G0269176 R-DDI-9714480 https://reactome.org/PathwayBrowser/#/R-DDI-9714480 RAC2 translocates to the mitochondrial membrane IEA Dictyostelium discoideum DDB_G0269176 R-DDI-9714483 https://reactome.org/PathwayBrowser/#/R-DDI-9714483 RAC2 translocates to the ER membrane IEA Dictyostelium discoideum DDB_G0269178 R-DDI-1011598 https://reactome.org/PathwayBrowser/#/R-DDI-1011598 DOCKs bind to RhoGEFs IEA Dictyostelium discoideum DDB_G0269178 R-DDI-2029454 https://reactome.org/PathwayBrowser/#/R-DDI-2029454 Autophosphorylation of PAK1 IEA Dictyostelium discoideum DDB_G0269178 R-DDI-2029456 https://reactome.org/PathwayBrowser/#/R-DDI-2029456 RAC1 and CDC42 activate PAK1 IEA Dictyostelium discoideum DDB_G0269178 R-DDI-2029466 https://reactome.org/PathwayBrowser/#/R-DDI-2029466 (WASPs, WAVE):G-actin:ARP2/3 binds F-actin IEA Dictyostelium discoideum DDB_G0269178 R-DDI-2197690 https://reactome.org/PathwayBrowser/#/R-DDI-2197690 Detachment of WASP/WAVE IEA Dictyostelium discoideum DDB_G0269178 R-DDI-389788 https://reactome.org/PathwayBrowser/#/R-DDI-389788 Activation of PAKs by RAC1 and CDC42 IEA Dictyostelium discoideum DDB_G0269178 R-DDI-5626469 https://reactome.org/PathwayBrowser/#/R-DDI-5626469 GTP-bound RAC1 and CDC42 bind IQGAPs IEA Dictyostelium discoideum DDB_G0269178 R-DDI-5626507 https://reactome.org/PathwayBrowser/#/R-DDI-5626507 IQGAPs bind F-actin, which is inhibited by calmodulin IEA Dictyostelium discoideum DDB_G0269178 R-DDI-5626549 https://reactome.org/PathwayBrowser/#/R-DDI-5626549 IQGAPs bind CALM1 IEA Dictyostelium discoideum DDB_G0269178 R-DDI-5627775 https://reactome.org/PathwayBrowser/#/R-DDI-5627775 Autophosphorylation of PAK1,2,3 IEA Dictyostelium discoideum DDB_G0269178 R-DDI-5672329 https://reactome.org/PathwayBrowser/#/R-DDI-5672329 IQGAP1 binds CLIP1 and microtubules IEA Dictyostelium discoideum DDB_G0269178 R-DDI-8981926 https://reactome.org/PathwayBrowser/#/R-DDI-8981926 RAC1 and CDC42 activate PAK3 IEA Dictyostelium discoideum DDB_G0269178 R-DDI-8981931 https://reactome.org/PathwayBrowser/#/R-DDI-8981931 RAC1 and CDC42 activate PAK2 IEA Dictyostelium discoideum DDB_G0269178 R-DDI-9013145 https://reactome.org/PathwayBrowser/#/R-DDI-9013145 RAC1 binds effectors at the plasma membrane IEA Dictyostelium discoideum DDB_G0269178 R-DDI-9013158 https://reactome.org/PathwayBrowser/#/R-DDI-9013158 CDC42 GDIs block activation of CDC42 IEA Dictyostelium discoideum DDB_G0269178 R-DDI-9013159 https://reactome.org/PathwayBrowser/#/R-DDI-9013159 CDC42 GEFs activate CDC42 IEA Dictyostelium discoideum DDB_G0269178 R-DDI-9013161 https://reactome.org/PathwayBrowser/#/R-DDI-9013161 CDC42 GAPs stimulate CDC42 GTPase activity IEA Dictyostelium discoideum DDB_G0269178 R-DDI-9014294 https://reactome.org/PathwayBrowser/#/R-DDI-9014294 RAC2 binds effectors at the plasma membrane IEA Dictyostelium discoideum DDB_G0269178 R-DDI-9014449 https://reactome.org/PathwayBrowser/#/R-DDI-9014449 RHOG binds effectors at the plasma membrane IEA Dictyostelium discoideum DDB_G0269178 R-DDI-9017488 https://reactome.org/PathwayBrowser/#/R-DDI-9017488 RHOJ GAPs stimulate RHOJ GTPase activity IEA Dictyostelium discoideum DDB_G0269178 R-DDI-9017491 https://reactome.org/PathwayBrowser/#/R-DDI-9017491 RHOJ GEFs activate RHOJ IEA Dictyostelium discoideum DDB_G0269178 R-DDI-9018745 https://reactome.org/PathwayBrowser/#/R-DDI-9018745 RHOQ GAPs stimulate RHOQ GTPase activity IEA Dictyostelium discoideum DDB_G0269178 R-DDI-9018746 https://reactome.org/PathwayBrowser/#/R-DDI-9018746 RHOQ binds effectors at the plasma membrane IEA Dictyostelium discoideum DDB_G0269178 R-DDI-9018747 https://reactome.org/PathwayBrowser/#/R-DDI-9018747 RHOQ GEFs activate RHOQ IEA Dictyostelium discoideum DDB_G0269178 R-DDI-9018766 https://reactome.org/PathwayBrowser/#/R-DDI-9018766 RHOU binds effectors at the plasma membrane IEA Dictyostelium discoideum DDB_G0269178 R-DDI-9018768 https://reactome.org/PathwayBrowser/#/R-DDI-9018768 RHOU auto-activates IEA Dictyostelium discoideum DDB_G0269178 R-DDI-9018794 https://reactome.org/PathwayBrowser/#/R-DDI-9018794 RHOV binds effectors at the plasma membrane IEA Dictyostelium discoideum DDB_G0269178 R-DDI-9018798 https://reactome.org/PathwayBrowser/#/R-DDI-9018798 RHOV binds GTP IEA Dictyostelium discoideum DDB_G0269178 R-DDI-9018808 https://reactome.org/PathwayBrowser/#/R-DDI-9018808 RAC3 binds effectors at the plasma membrane IEA Dictyostelium discoideum DDB_G0269178 R-DDI-9018836 https://reactome.org/PathwayBrowser/#/R-DDI-9018836 RHOQ translocates to the Golgi-associated vesicle membranes IEA Dictyostelium discoideum DDB_G0269178 R-DDI-9692800 https://reactome.org/PathwayBrowser/#/R-DDI-9692800 CDC42 translocates to the endoplasmic reticulum membrane IEA Dictyostelium discoideum DDB_G0269178 R-DDI-9726862 https://reactome.org/PathwayBrowser/#/R-DDI-9726862 Phosphorylated RHOU translocates to the endosome membrane IEA Dictyostelium discoideum DDB_G0269186 R-DDI-5694423 https://reactome.org/PathwayBrowser/#/R-DDI-5694423 NSF and SNAPs bind cis-SNARE complex IEA Dictyostelium discoideum DDB_G0269186 R-DDI-5694425 https://reactome.org/PathwayBrowser/#/R-DDI-5694425 NSF ATPase activity dissociates cis-SNARE IEA Dictyostelium discoideum DDB_G0269186 R-DDI-6809014 https://reactome.org/PathwayBrowser/#/R-DDI-6809014 cis-Golgi cis-SNARE binds NSF and SNAPs IEA Dictyostelium discoideum DDB_G0269186 R-DDI-6809015 https://reactome.org/PathwayBrowser/#/R-DDI-6809015 NSF ATPase activity dissociates cis-SNARE at cis-Golgi IEA Dictyostelium discoideum DDB_G0269186 R-DDI-6811422 https://reactome.org/PathwayBrowser/#/R-DDI-6811422 NSF ATPase activity dissociates cis-SNARE at the ER IEA Dictyostelium discoideum DDB_G0269186 R-DDI-6811425 https://reactome.org/PathwayBrowser/#/R-DDI-6811425 NSF and SNAPs bind cis-SNARE at the ER membrane IEA Dictyostelium discoideum DDB_G0269186 R-DDI-6814676 https://reactome.org/PathwayBrowser/#/R-DDI-6814676 SNAPs and NSF hexamer bind cis-SNARE at the TGN IEA Dictyostelium discoideum DDB_G0269186 R-DDI-6814678 https://reactome.org/PathwayBrowser/#/R-DDI-6814678 ATP hydrolysis by NSF disassembles the cis-SNARE at the TGN IEA Dictyostelium discoideum DDB_G0269186 R-DDI-6814684 https://reactome.org/PathwayBrowser/#/R-DDI-6814684 cis-SNARE binds SNAPs and NSF hexamer at the TGN IEA Dictyostelium discoideum DDB_G0269186 R-DDI-8847637 https://reactome.org/PathwayBrowser/#/R-DDI-8847637 NSF and SNAPs bind the cis-SNARE at the Golgi IEA Dictyostelium discoideum DDB_G0269186 R-DDI-8847638 https://reactome.org/PathwayBrowser/#/R-DDI-8847638 ATP hydrolysis by NSF disassembles the cis-SNARE at the Golgi membrane IEA Dictyostelium discoideum DDB_G0269188 R-DDI-9770236 https://reactome.org/PathwayBrowser/#/R-DDI-9770236 Formation of the Spliceosomal P complex and exon ligation IEA Dictyostelium discoideum DDB_G0269190 R-DDI-391266 https://reactome.org/PathwayBrowser/#/R-DDI-391266 Association of CCT/TriC with sphingosine kinase 1 IEA Dictyostelium discoideum DDB_G0269190 R-DDI-6814119 https://reactome.org/PathwayBrowser/#/R-DDI-6814119 TRiC/CCT binds unfolded G-protein beta subunit IEA Dictyostelium discoideum DDB_G0269190 R-DDI-6814120 https://reactome.org/PathwayBrowser/#/R-DDI-6814120 ATP hydrolysis promotes folding of G-protein beta by TRiC/CCT IEA Dictyostelium discoideum DDB_G0269190 R-DDI-6814124 https://reactome.org/PathwayBrowser/#/R-DDI-6814124 ATP binds G-protein beta associated TRiC/CCT IEA Dictyostelium discoideum DDB_G0269192 R-DDI-1678842 https://reactome.org/PathwayBrowser/#/R-DDI-1678842 Competitive inhibition of translation initiation by ISGylated 4EHP IEA Dictyostelium discoideum DDB_G0269192 R-DDI-927832 https://reactome.org/PathwayBrowser/#/R-DDI-927832 UPF1 binds an mRNP with a termination codon preceding an Exon Junction Complex IEA Dictyostelium discoideum DDB_G0269192 R-DDI-927889 https://reactome.org/PathwayBrowser/#/R-DDI-927889 SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex) IEA Dictyostelium discoideum DDB_G0269192 R-DDI-9770236 https://reactome.org/PathwayBrowser/#/R-DDI-9770236 Formation of the Spliceosomal P complex and exon ligation IEA Dictyostelium discoideum DDB_G0269194 R-DDI-3222593 https://reactome.org/PathwayBrowser/#/R-DDI-3222593 KDM6B demethylates H3K27me3 on p16INK4A promoter IEA Dictyostelium discoideum DDB_G0269194 R-DDI-4754187 https://reactome.org/PathwayBrowser/#/R-DDI-4754187 KDM6A, KDM6B, KDM7A demethylate Me2K28-histone H3 IEA Dictyostelium discoideum DDB_G0269194 R-DDI-5661121 https://reactome.org/PathwayBrowser/#/R-DDI-5661121 KDM6A, KDM6B, KDM7A demethylate Me3K28-histone H3 IEA Dictyostelium discoideum DDB_G0269194 R-DDI-8979071 https://reactome.org/PathwayBrowser/#/R-DDI-8979071 KDM6B binds iron IEA Dictyostelium discoideum DDB_G0269196 R-DDI-5610733 https://reactome.org/PathwayBrowser/#/R-DDI-5610733 KIF7 is recruited to the ciliary tip through interaction with axonemal microtubules IEA Dictyostelium discoideum DDB_G0269196 R-DDI-5618331 https://reactome.org/PathwayBrowser/#/R-DDI-5618331 HDAC6 deacetylates microtubules IEA Dictyostelium discoideum DDB_G0269196 R-DDI-5672329 https://reactome.org/PathwayBrowser/#/R-DDI-5672329 IQGAP1 binds CLIP1 and microtubules IEA Dictyostelium discoideum DDB_G0269196 R-DDI-6798751 https://reactome.org/PathwayBrowser/#/R-DDI-6798751 Exocytosis of azurophil granule lumen proteins IEA Dictyostelium discoideum DDB_G0269196 R-DDI-6809003 https://reactome.org/PathwayBrowser/#/R-DDI-6809003 ERGIC-to-Golgi vesicles bind dynein:dynactin IEA Dictyostelium discoideum DDB_G0269196 R-DDI-8867370 https://reactome.org/PathwayBrowser/#/R-DDI-8867370 TTLL3, TTLL8, TTLL10 polyglycylate tubulin IEA Dictyostelium discoideum DDB_G0269196 R-DDI-9646685 https://reactome.org/PathwayBrowser/#/R-DDI-9646685 Aggresome dissociates from dynein and microtubule IEA Dictyostelium discoideum DDB_G0269196 R-DDI-9668419 https://reactome.org/PathwayBrowser/#/R-DDI-9668419 SPAST (spastin) mediates the severing of microtubules at chromosome attachment sites IEA Dictyostelium discoideum DDB_G0269198 R-DDI-204008 https://reactome.org/PathwayBrowser/#/R-DDI-204008 SEC31:SEC13 and v-SNARE recruitment IEA Dictyostelium discoideum DDB_G0269200 R-DDI-6800434 https://reactome.org/PathwayBrowser/#/R-DDI-6800434 Exocytosis of ficolin-rich granule lumen proteins IEA Dictyostelium discoideum DDB_G0269214 R-DDI-1454928 https://reactome.org/PathwayBrowser/#/R-DDI-1454928 ABCG4 may mediate cholesterol efflux IEA Dictyostelium discoideum DDB_G0269214 R-DDI-266082 https://reactome.org/PathwayBrowser/#/R-DDI-266082 ABCG1-mediated transport of intracellular cholesterol to the cell surface IEA Dictyostelium discoideum DDB_G0269216 R-DDI-9770236 https://reactome.org/PathwayBrowser/#/R-DDI-9770236 Formation of the Spliceosomal P complex and exon ligation IEA Dictyostelium discoideum DDB_G0269218 R-DDI-9866253 https://reactome.org/PathwayBrowser/#/R-DDI-9866253 apo-UQCRFS1 binds LYRM7 IEA Dictyostelium discoideum DDB_G0269218 R-DDI-9866272 https://reactome.org/PathwayBrowser/#/R-DDI-9866272 2Fe-2S is inserted in UQCRFS1 IEA Dictyostelium discoideum DDB_G0269222 R-DDI-205039 https://reactome.org/PathwayBrowser/#/R-DDI-205039 p75NTR indirectly activates RAC and Cdc42 via a guanyl-nucleotide exchange factor IEA Dictyostelium discoideum DDB_G0269222 R-DDI-9013143 https://reactome.org/PathwayBrowser/#/R-DDI-9013143 RAC1 GEFs activate RAC1 IEA Dictyostelium discoideum DDB_G0269222 R-DDI-9013159 https://reactome.org/PathwayBrowser/#/R-DDI-9013159 CDC42 GEFs activate CDC42 IEA Dictyostelium discoideum DDB_G0269226 R-DDI-191366 https://reactome.org/PathwayBrowser/#/R-DDI-191366 Squalene 2,3-epoxide cyclizes, forming lanosterol IEA Dictyostelium discoideum DDB_G0269230 R-DDI-1363328 https://reactome.org/PathwayBrowser/#/R-DDI-1363328 Phosphorylated p130 (RBL2) binds SCF(Skp2):Cks1 complex IEA Dictyostelium discoideum DDB_G0269230 R-DDI-1363331 https://reactome.org/PathwayBrowser/#/R-DDI-1363331 Ubiquitination of p130 (RBL2) by SCF (Skp2) IEA Dictyostelium discoideum DDB_G0269230 R-DDI-5691108 https://reactome.org/PathwayBrowser/#/R-DDI-5691108 SKP1:FBXL5:CUL1:NEDD8 ubiquitinylates IREB2 IEA Dictyostelium discoideum DDB_G0269230 R-DDI-68946 https://reactome.org/PathwayBrowser/#/R-DDI-68946 Phosphorylated Orc1 is ubiquitinated while still associated with chromatin IEA Dictyostelium discoideum DDB_G0269230 R-DDI-8853496 https://reactome.org/PathwayBrowser/#/R-DDI-8853496 SCF:FBXL7 binds AURKA IEA Dictyostelium discoideum DDB_G0269230 R-DDI-8854041 https://reactome.org/PathwayBrowser/#/R-DDI-8854041 SCF-FBXL7 ubiquitinates AURKA IEA Dictyostelium discoideum DDB_G0269230 R-DDI-8854044 https://reactome.org/PathwayBrowser/#/R-DDI-8854044 Proteasome degrades AURKA ubiquitinated by SCF-FBXL7 IEA Dictyostelium discoideum DDB_G0269230 R-DDI-8952618 https://reactome.org/PathwayBrowser/#/R-DDI-8952618 AcM-UBE2M transfers NEDD8 to CRL1 E3 ubiquitin ligase complex IEA Dictyostelium discoideum DDB_G0269230 R-DDI-8952620 https://reactome.org/PathwayBrowser/#/R-DDI-8952620 NEDD8:AcM-UBE2M binds CRL1 E3 ubiquitin ligase complex IEA Dictyostelium discoideum DDB_G0269230 R-DDI-8955241 https://reactome.org/PathwayBrowser/#/R-DDI-8955241 CAND1 binds cytosolic CRL E3 ubiquitin ligases IEA Dictyostelium discoideum DDB_G0269230 R-DDI-8955289 https://reactome.org/PathwayBrowser/#/R-DDI-8955289 COMMDs displace CAND1 from cytosolic CRL E3 ubiquitin ligase complexes IEA Dictyostelium discoideum DDB_G0269230 R-DDI-8956040 https://reactome.org/PathwayBrowser/#/R-DDI-8956040 COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes IEA Dictyostelium discoideum DDB_G0269230 R-DDI-8956200 https://reactome.org/PathwayBrowser/#/R-DDI-8956200 MyrG-DCUN1D3 binds CRL1 E3 ubiquitin ligase complex IEA Dictyostelium discoideum DDB_G0269230 R-DDI-983140 https://reactome.org/PathwayBrowser/#/R-DDI-983140 Transfer of Ub from E2 to substrate and release of E2 IEA Dictyostelium discoideum DDB_G0269230 R-DDI-983147 https://reactome.org/PathwayBrowser/#/R-DDI-983147 Release of E3 from polyubiquitinated substrate IEA Dictyostelium discoideum DDB_G0269230 R-DDI-983156 https://reactome.org/PathwayBrowser/#/R-DDI-983156 Polyubiquitination of substrate IEA Dictyostelium discoideum DDB_G0269230 R-DDI-983157 https://reactome.org/PathwayBrowser/#/R-DDI-983157 Interaction of E3 with substrate and E2-Ub complex IEA Dictyostelium discoideum DDB_G0269236 R-DDI-6798743 https://reactome.org/PathwayBrowser/#/R-DDI-6798743 Exocytosis of secretory granule membrane proteins IEA Dictyostelium discoideum DDB_G0269236 R-DDI-8854255 https://reactome.org/PathwayBrowser/#/R-DDI-8854255 TBC1D2A accelerates GTP hydrolysis by RAB7 IEA Dictyostelium discoideum DDB_G0269236 R-DDI-8854329 https://reactome.org/PathwayBrowser/#/R-DDI-8854329 TBC1D15 accelerates GTP hydrolysis by RAB7 IEA Dictyostelium discoideum DDB_G0269236 R-DDI-8870466 https://reactome.org/PathwayBrowser/#/R-DDI-8870466 RGGT:CHM binds RABs IEA Dictyostelium discoideum DDB_G0269236 R-DDI-8870469 https://reactome.org/PathwayBrowser/#/R-DDI-8870469 RGGT geranylgeranylates RAB proteins IEA Dictyostelium discoideum DDB_G0269236 R-DDI-8876191 https://reactome.org/PathwayBrowser/#/R-DDI-8876191 RAB9 GEFs exchange GTP for GDP on RAB9 IEA Dictyostelium discoideum DDB_G0269236 R-DDI-8877451 https://reactome.org/PathwayBrowser/#/R-DDI-8877451 MON1:CCZ1 exchanges GTP for GDP on RAB7 IEA Dictyostelium discoideum DDB_G0269236 R-DDI-9013145 https://reactome.org/PathwayBrowser/#/R-DDI-9013145 RAC1 binds effectors at the plasma membrane IEA Dictyostelium discoideum DDB_G0269236 R-DDI-9014294 https://reactome.org/PathwayBrowser/#/R-DDI-9014294 RAC2 binds effectors at the plasma membrane IEA Dictyostelium discoideum DDB_G0269236 R-DDI-9014449 https://reactome.org/PathwayBrowser/#/R-DDI-9014449 RHOG binds effectors at the plasma membrane IEA Dictyostelium discoideum DDB_G0269236 R-DDI-9018746 https://reactome.org/PathwayBrowser/#/R-DDI-9018746 RHOQ binds effectors at the plasma membrane IEA Dictyostelium discoideum DDB_G0269236 R-DDI-9018758 https://reactome.org/PathwayBrowser/#/R-DDI-9018758 RHOH binds effectors at the plasma membrane IEA Dictyostelium discoideum DDB_G0269236 R-DDI-9018808 https://reactome.org/PathwayBrowser/#/R-DDI-9018808 RAC3 binds effectors at the plasma membrane IEA Dictyostelium discoideum DDB_G0269236 R-DDI-9706390 https://reactome.org/PathwayBrowser/#/R-DDI-9706390 RHOBTB3 binds interacting proteins at trans-Golgi network IEA Dictyostelium discoideum DDB_G0269238 R-DDI-8854759 https://reactome.org/PathwayBrowser/#/R-DDI-8854759 TBC1D14 binds RAB11 and ULK1 IEA Dictyostelium discoideum DDB_G0269238 R-DDI-8870466 https://reactome.org/PathwayBrowser/#/R-DDI-8870466 RGGT:CHM binds RABs IEA Dictyostelium discoideum DDB_G0269238 R-DDI-8870469 https://reactome.org/PathwayBrowser/#/R-DDI-8870469 RGGT geranylgeranylates RAB proteins IEA Dictyostelium discoideum DDB_G0269240 R-DDI-6798743 https://reactome.org/PathwayBrowser/#/R-DDI-6798743 Exocytosis of secretory granule membrane proteins IEA Dictyostelium discoideum DDB_G0269240 R-DDI-9014293 https://reactome.org/PathwayBrowser/#/R-DDI-9014293 RAC2 GDIs block activation of RAC2 IEA Dictyostelium discoideum DDB_G0269240 R-DDI-9014294 https://reactome.org/PathwayBrowser/#/R-DDI-9014294 RAC2 binds effectors at the plasma membrane IEA Dictyostelium discoideum DDB_G0269240 R-DDI-9014295 https://reactome.org/PathwayBrowser/#/R-DDI-9014295 RAC2 GAPs stimulate RAC2 GTPase activity IEA Dictyostelium discoideum DDB_G0269240 R-DDI-9014296 https://reactome.org/PathwayBrowser/#/R-DDI-9014296 RAC2 GEFs activate RAC2 IEA Dictyostelium discoideum DDB_G0269240 R-DDI-9014420 https://reactome.org/PathwayBrowser/#/R-DDI-9014420 RAC2 translocates to the phagocytic vesicle membrane IEA Dictyostelium discoideum DDB_G0269240 R-DDI-9014433 https://reactome.org/PathwayBrowser/#/R-DDI-9014433 RHOG GEFs activate RHOG IEA Dictyostelium discoideum DDB_G0269240 R-DDI-9014449 https://reactome.org/PathwayBrowser/#/R-DDI-9014449 RHOG binds effectors at the plasma membrane IEA Dictyostelium discoideum DDB_G0269240 R-DDI-9014454 https://reactome.org/PathwayBrowser/#/R-DDI-9014454 RHOG translocates to the ER membrane IEA Dictyostelium discoideum DDB_G0269240 R-DDI-9014456 https://reactome.org/PathwayBrowser/#/R-DDI-9014456 GDIs block activation of RHOG IEA Dictyostelium discoideum DDB_G0269240 R-DDI-9018754 https://reactome.org/PathwayBrowser/#/R-DDI-9018754 GDIs bind RHOH IEA Dictyostelium discoideum DDB_G0269240 R-DDI-9018756 https://reactome.org/PathwayBrowser/#/R-DDI-9018756 RHOH binds GTP IEA Dictyostelium discoideum DDB_G0269240 R-DDI-9018758 https://reactome.org/PathwayBrowser/#/R-DDI-9018758 RHOH binds effectors at the plasma membrane IEA Dictyostelium discoideum DDB_G0269240 R-DDI-9018774 https://reactome.org/PathwayBrowser/#/R-DDI-9018774 RHOBTB1 binds GTP IEA Dictyostelium discoideum DDB_G0269240 R-DDI-9018778 https://reactome.org/PathwayBrowser/#/R-DDI-9018778 RHOBTB1 binds interacting proteins at the endosome membrane IEA Dictyostelium discoideum DDB_G0269240 R-DDI-9018787 https://reactome.org/PathwayBrowser/#/R-DDI-9018787 RHOBTB2 binds interacting proteins at the endosome membrane IEA Dictyostelium discoideum DDB_G0269240 R-DDI-9714477 https://reactome.org/PathwayBrowser/#/R-DDI-9714477 RAC2 binds effectors at the mitochondrial outer membrane IEA Dictyostelium discoideum DDB_G0269240 R-DDI-9714480 https://reactome.org/PathwayBrowser/#/R-DDI-9714480 RAC2 translocates to the mitochondrial membrane IEA Dictyostelium discoideum DDB_G0269240 R-DDI-9714483 https://reactome.org/PathwayBrowser/#/R-DDI-9714483 RAC2 translocates to the ER membrane IEA Dictyostelium discoideum DDB_G0269242 R-DDI-201035 https://reactome.org/PathwayBrowser/#/R-DDI-201035 ACSL1,3,5,6 ligate CoA to PALM to form PALM-CoA IEA Dictyostelium discoideum DDB_G0269242 R-DDI-2046085 https://reactome.org/PathwayBrowser/#/R-DDI-2046085 Activation of alpha-linolenic acid to alpha-linolenoyl-CoA IEA Dictyostelium discoideum DDB_G0269242 R-DDI-2046098 https://reactome.org/PathwayBrowser/#/R-DDI-2046098 Activation of linoleic acid to linoleoyl-CoA IEA Dictyostelium discoideum DDB_G0269246 R-DDI-73589 https://reactome.org/PathwayBrowser/#/R-DDI-73589 5,6-dihydrouracil + H2O => beta-ureidopropionate IEA Dictyostelium discoideum DDB_G0269246 R-DDI-73618 https://reactome.org/PathwayBrowser/#/R-DDI-73618 5,6-dihydrothymine + H2O => beta-ureidoisobutyrate IEA Dictyostelium discoideum DDB_G0269250 R-DDI-1675795 https://reactome.org/PathwayBrowser/#/R-DDI-1675795 PI3P is dephosphorylated to PI by MTM proteins at the late endosome membrane IEA Dictyostelium discoideum DDB_G0269250 R-DDI-1675994 https://reactome.org/PathwayBrowser/#/R-DDI-1675994 PI3P is dephosphorylated to PI by SYNJ/MTMs at the plasma membrane IEA Dictyostelium discoideum DDB_G0269250 R-DDI-1676065 https://reactome.org/PathwayBrowser/#/R-DDI-1676065 PI(3,5)P2 is dephosphorylated to PI5P by MTM proteins at the late endosome membrane IEA Dictyostelium discoideum DDB_G0269250 R-DDI-1676105 https://reactome.org/PathwayBrowser/#/R-DDI-1676105 PI(3,5)P2 is dephosphorylated to PI5P by MTM proteins at the early endosome membrane IEA Dictyostelium discoideum DDB_G0269250 R-DDI-1676141 https://reactome.org/PathwayBrowser/#/R-DDI-1676141 PI3P is dephosphorylated to PI by MTM proteins at the early endosome membrane IEA Dictyostelium discoideum DDB_G0269250 R-DDI-1676203 https://reactome.org/PathwayBrowser/#/R-DDI-1676203 PI(3,5)P2 is dephosphorylated to PI5P by SYNJ/MTMs at the plasma membrane IEA Dictyostelium discoideum DDB_G0269250 R-DDI-5679206 https://reactome.org/PathwayBrowser/#/R-DDI-5679206 MTMR14, MTMR3 dephosphorylate PI3P IEA Dictyostelium discoideum DDB_G0269250 R-DDI-6809254 https://reactome.org/PathwayBrowser/#/R-DDI-6809254 MTMR8 binds MTMR9 IEA Dictyostelium discoideum DDB_G0269250 R-DDI-6809309 https://reactome.org/PathwayBrowser/#/R-DDI-6809309 MTMR6 binds MTMR9 IEA Dictyostelium discoideum DDB_G0269250 R-DDI-6809320 https://reactome.org/PathwayBrowser/#/R-DDI-6809320 PI(3,5)P2 is dephosphorylated to PI5P by MTMR9-bound MTMR6 or MTMR8 at the plasma membrane IEA Dictyostelium discoideum DDB_G0269250 R-DDI-6809325 https://reactome.org/PathwayBrowser/#/R-DDI-6809325 PI3P is dephosphorylated to PI by MTMR9-bound MTMR8 or MTMR6 at the plasma membrane IEA Dictyostelium discoideum DDB_G0269250 R-DDI-6809680 https://reactome.org/PathwayBrowser/#/R-DDI-6809680 MTMR12 binds MTM1 IEA Dictyostelium discoideum DDB_G0269250 R-DDI-6809707 https://reactome.org/PathwayBrowser/#/R-DDI-6809707 MTMR12 binds MTMR2 IEA Dictyostelium discoideum DDB_G0269250 R-DDI-6809720 https://reactome.org/PathwayBrowser/#/R-DDI-6809720 PI3P is dephosphorylated to PI by MTM1:MTMR12 IEA Dictyostelium discoideum DDB_G0269250 R-DDI-6809764 https://reactome.org/PathwayBrowser/#/R-DDI-6809764 SBF1 binds MTMR2 IEA Dictyostelium discoideum DDB_G0269250 R-DDI-6809777 https://reactome.org/PathwayBrowser/#/R-DDI-6809777 PI3P is dephosphorylated to PI by MTMR2:SBF1 IEA Dictyostelium discoideum DDB_G0269250 R-DDI-6809778 https://reactome.org/PathwayBrowser/#/R-DDI-6809778 PI(3,5)P2 is dephosphorylated to PI5P by MTMR2:SBF1 IEA Dictyostelium discoideum DDB_G0269250 R-DDI-8876837 https://reactome.org/PathwayBrowser/#/R-DDI-8876837 RAB21 GEFs exchange GTP for GDP on RAB21 IEA Dictyostelium discoideum DDB_G0269252 R-DDI-205039 https://reactome.org/PathwayBrowser/#/R-DDI-205039 p75NTR indirectly activates RAC and Cdc42 via a guanyl-nucleotide exchange factor IEA Dictyostelium discoideum DDB_G0269252 R-DDI-9013143 https://reactome.org/PathwayBrowser/#/R-DDI-9013143 RAC1 GEFs activate RAC1 IEA Dictyostelium discoideum DDB_G0269252 R-DDI-9013159 https://reactome.org/PathwayBrowser/#/R-DDI-9013159 CDC42 GEFs activate CDC42 IEA Dictyostelium discoideum DDB_G0269262 R-DDI-6798739 https://reactome.org/PathwayBrowser/#/R-DDI-6798739 Exocytosis of azurophil granule membrane proteins IEA Dictyostelium discoideum DDB_G0269262 R-DDI-6798749 https://reactome.org/PathwayBrowser/#/R-DDI-6798749 Exocytosis of specific granule lumen proteins IEA Dictyostelium discoideum DDB_G0269262 R-DDI-6799350 https://reactome.org/PathwayBrowser/#/R-DDI-6799350 Exocytosis of specific granule membrane proteins IEA Dictyostelium discoideum DDB_G0269262 R-DDI-8849748 https://reactome.org/PathwayBrowser/#/R-DDI-8849748 The COG complex binds RABs at the Golgi membrane IEA Dictyostelium discoideum DDB_G0269262 R-DDI-8870466 https://reactome.org/PathwayBrowser/#/R-DDI-8870466 RGGT:CHM binds RABs IEA Dictyostelium discoideum DDB_G0269262 R-DDI-8870469 https://reactome.org/PathwayBrowser/#/R-DDI-8870469 RGGT geranylgeranylates RAB proteins IEA Dictyostelium discoideum DDB_G0269272 R-DDI-1675795 https://reactome.org/PathwayBrowser/#/R-DDI-1675795 PI3P is dephosphorylated to PI by MTM proteins at the late endosome membrane IEA Dictyostelium discoideum DDB_G0269272 R-DDI-1675994 https://reactome.org/PathwayBrowser/#/R-DDI-1675994 PI3P is dephosphorylated to PI by SYNJ/MTMs at the plasma membrane IEA Dictyostelium discoideum DDB_G0269272 R-DDI-1676065 https://reactome.org/PathwayBrowser/#/R-DDI-1676065 PI(3,5)P2 is dephosphorylated to PI5P by MTM proteins at the late endosome membrane IEA Dictyostelium discoideum DDB_G0269272 R-DDI-1676105 https://reactome.org/PathwayBrowser/#/R-DDI-1676105 PI(3,5)P2 is dephosphorylated to PI5P by MTM proteins at the early endosome membrane IEA Dictyostelium discoideum DDB_G0269272 R-DDI-1676141 https://reactome.org/PathwayBrowser/#/R-DDI-1676141 PI3P is dephosphorylated to PI by MTM proteins at the early endosome membrane IEA Dictyostelium discoideum DDB_G0269272 R-DDI-1676203 https://reactome.org/PathwayBrowser/#/R-DDI-1676203 PI(3,5)P2 is dephosphorylated to PI5P by SYNJ/MTMs at the plasma membrane IEA Dictyostelium discoideum DDB_G0269272 R-DDI-5679206 https://reactome.org/PathwayBrowser/#/R-DDI-5679206 MTMR14, MTMR3 dephosphorylate PI3P IEA Dictyostelium discoideum DDB_G0269272 R-DDI-6809254 https://reactome.org/PathwayBrowser/#/R-DDI-6809254 MTMR8 binds MTMR9 IEA Dictyostelium discoideum DDB_G0269272 R-DDI-6809309 https://reactome.org/PathwayBrowser/#/R-DDI-6809309 MTMR6 binds MTMR9 IEA Dictyostelium discoideum DDB_G0269272 R-DDI-6809320 https://reactome.org/PathwayBrowser/#/R-DDI-6809320 PI(3,5)P2 is dephosphorylated to PI5P by MTMR9-bound MTMR6 or MTMR8 at the plasma membrane IEA Dictyostelium discoideum DDB_G0269272 R-DDI-6809325 https://reactome.org/PathwayBrowser/#/R-DDI-6809325 PI3P is dephosphorylated to PI by MTMR9-bound MTMR8 or MTMR6 at the plasma membrane IEA Dictyostelium discoideum DDB_G0269272 R-DDI-6809680 https://reactome.org/PathwayBrowser/#/R-DDI-6809680 MTMR12 binds MTM1 IEA Dictyostelium discoideum DDB_G0269272 R-DDI-6809707 https://reactome.org/PathwayBrowser/#/R-DDI-6809707 MTMR12 binds MTMR2 IEA Dictyostelium discoideum DDB_G0269272 R-DDI-6809720 https://reactome.org/PathwayBrowser/#/R-DDI-6809720 PI3P is dephosphorylated to PI by MTM1:MTMR12 IEA Dictyostelium discoideum DDB_G0269272 R-DDI-6809764 https://reactome.org/PathwayBrowser/#/R-DDI-6809764 SBF1 binds MTMR2 IEA Dictyostelium discoideum DDB_G0269272 R-DDI-6809777 https://reactome.org/PathwayBrowser/#/R-DDI-6809777 PI3P is dephosphorylated to PI by MTMR2:SBF1 IEA Dictyostelium discoideum DDB_G0269272 R-DDI-6809778 https://reactome.org/PathwayBrowser/#/R-DDI-6809778 PI(3,5)P2 is dephosphorylated to PI5P by MTMR2:SBF1 IEA Dictyostelium discoideum DDB_G0269272 R-DDI-8876837 https://reactome.org/PathwayBrowser/#/R-DDI-8876837 RAB21 GEFs exchange GTP for GDP on RAB21 IEA Dictyostelium discoideum DDB_G0269274 R-DDI-70349 https://reactome.org/PathwayBrowser/#/R-DDI-70349 DAK dimer phosphorylates D-glyceraldehyde to form D-glyceraldehyde 3-phosphate IEA Dictyostelium discoideum DDB_G0269284 R-DDI-9770236 https://reactome.org/PathwayBrowser/#/R-DDI-9770236 Formation of the Spliceosomal P complex and exon ligation IEA Dictyostelium discoideum DDB_G0269292 R-DDI-874087 https://reactome.org/PathwayBrowser/#/R-DDI-874087 SGT1 binds HSP90 IEA Dictyostelium discoideum DDB_G0269304 R-DDI-9671145 https://reactome.org/PathwayBrowser/#/R-DDI-9671145 DKC1 binds SHQ1 IEA Dictyostelium discoideum DDB_G0269324 R-DDI-176956 https://reactome.org/PathwayBrowser/#/R-DDI-176956 Formation of GINS complex IEA Dictyostelium discoideum DDB_G0269326 R-DDI-442422 https://reactome.org/PathwayBrowser/#/R-DDI-442422 SLC39A1-4 transports Zn2+ from extracellular region to cytosol IEA Dictyostelium discoideum DDB_G0269332 R-DDI-437085 https://reactome.org/PathwayBrowser/#/R-DDI-437085 ZnT5 transports zinc into secretory granules in pancreatic beta cells IEA Dictyostelium discoideum DDB_G0269332 R-DDI-9820566 https://reactome.org/PathwayBrowser/#/R-DDI-9820566 ZnT5 transports zinc into the golgi apparatus IEA Dictyostelium discoideum DDB_G0269344 R-DDI-9676160 https://reactome.org/PathwayBrowser/#/R-DDI-9676160 AAMP binds NOD2 IEA Dictyostelium discoideum DDB_G0269352 R-DDI-70634 https://reactome.org/PathwayBrowser/#/R-DDI-70634 ornithine (cytosolic) + citrulline (mitochondrial) => ornithine (mitochondrial) + citrulline (cytosolic) IEA Dictyostelium discoideum DDB_G0269356 R-DDI-8862152 https://reactome.org/PathwayBrowser/#/R-DDI-8862152 2xHSD17B8:2xCBR4 reduces 3OA-ACP to 3HA-ACP IEA Dictyostelium discoideum DDB_G0269364 R-DDI-163756 https://reactome.org/PathwayBrowser/#/R-DDI-163756 Formation of fatty acid synthase (FAS) dimer IEA Dictyostelium discoideum DDB_G0269364 R-DDI-199202 https://reactome.org/PathwayBrowser/#/R-DDI-199202 Phosphopantetheine conjugation of the ACP domain of FAS IEA Dictyostelium discoideum DDB_G0269364 R-DDI-75872 https://reactome.org/PathwayBrowser/#/R-DDI-75872 Conversion of malonyl-CoA and acetyl-CoA to palmitate IEA Dictyostelium discoideum DDB_G0269368 R-DDI-6814086 https://reactome.org/PathwayBrowser/#/R-DDI-6814086 ARFRP1 recruits ARL1 to the TGN IEA Dictyostelium discoideum DDB_G0269368 R-DDI-6814088 https://reactome.org/PathwayBrowser/#/R-DDI-6814088 SYS1 binds AcM-ARFRP1 IEA Dictyostelium discoideum DDB_G0269368 R-DDI-6814091 https://reactome.org/PathwayBrowser/#/R-DDI-6814091 ARL1 recruits TGN Golgin homodimers IEA Dictyostelium discoideum DDB_G0269378 R-DDI-176264 https://reactome.org/PathwayBrowser/#/R-DDI-176264 Recruitment of the Rad9-Hus1-Rad1 complex to DNA IEA Dictyostelium discoideum DDB_G0269380 R-DDI-6798739 https://reactome.org/PathwayBrowser/#/R-DDI-6798739 Exocytosis of azurophil granule membrane proteins IEA Dictyostelium discoideum DDB_G0269380 R-DDI-6798747 https://reactome.org/PathwayBrowser/#/R-DDI-6798747 Exocytosis of tertiary granule membrane proteins IEA Dictyostelium discoideum DDB_G0269380 R-DDI-6799350 https://reactome.org/PathwayBrowser/#/R-DDI-6799350 Exocytosis of specific granule membrane proteins IEA Dictyostelium discoideum DDB_G0269380 R-DDI-939763 https://reactome.org/PathwayBrowser/#/R-DDI-939763 P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane IEA Dictyostelium discoideum DDB_G0269380 R-DDI-947591 https://reactome.org/PathwayBrowser/#/R-DDI-947591 P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane IEA Dictyostelium discoideum DDB_G0269406 R-DDI-4568863 https://reactome.org/PathwayBrowser/#/R-DDI-4568863 SUMOylation of RAD52 with SUMO1 IEA Dictyostelium discoideum DDB_G0269406 R-DDI-75998 https://reactome.org/PathwayBrowser/#/R-DDI-75998 Formation of RAD52 heptameric ring structure complexes IEA Dictyostelium discoideum DDB_G0269414 R-DDI-195690 https://reactome.org/PathwayBrowser/#/R-DDI-195690 Zymosterol is isomerized to cholesta-7,24-dien-3beta-ol IEA Dictyostelium discoideum DDB_G0269414 R-DDI-6807052 https://reactome.org/PathwayBrowser/#/R-DDI-6807052 EBP isomerizes ZYMSTNL to LTHSOL IEA Dictyostelium discoideum DDB_G0269432 R-DDI-5362412 https://reactome.org/PathwayBrowser/#/R-DDI-5362412 SYVN1 ubiquitinates Hh C-terminal fragments IEA Dictyostelium discoideum DDB_G0269440 R-DDI-6814555 https://reactome.org/PathwayBrowser/#/R-DDI-6814555 Integrator complex processes the 3' end of snRNA IEA Dictyostelium discoideum DDB_G0269440 R-DDI-6814559 https://reactome.org/PathwayBrowser/#/R-DDI-6814559 Pre-snRNA is elongated and capped with 7-methylguanosine IEA Dictyostelium discoideum DDB_G0269444 R-DDI-189439 https://reactome.org/PathwayBrowser/#/R-DDI-189439 ALAD condenses 2 dALAs to form PBG IEA Dictyostelium discoideum DDB_G0269444 R-DDI-6798748 https://reactome.org/PathwayBrowser/#/R-DDI-6798748 Exocytosis of secretory granule lumen proteins IEA Dictyostelium discoideum DDB_G0269444 R-DDI-6800434 https://reactome.org/PathwayBrowser/#/R-DDI-6800434 Exocytosis of ficolin-rich granule lumen proteins IEA Dictyostelium discoideum DDB_G0269448 R-DDI-1675795 https://reactome.org/PathwayBrowser/#/R-DDI-1675795 PI3P is dephosphorylated to PI by MTM proteins at the late endosome membrane IEA Dictyostelium discoideum DDB_G0269448 R-DDI-1675994 https://reactome.org/PathwayBrowser/#/R-DDI-1675994 PI3P is dephosphorylated to PI by SYNJ/MTMs at the plasma membrane IEA Dictyostelium discoideum DDB_G0269448 R-DDI-1676065 https://reactome.org/PathwayBrowser/#/R-DDI-1676065 PI(3,5)P2 is dephosphorylated to PI5P by MTM proteins at the late endosome membrane IEA Dictyostelium discoideum DDB_G0269448 R-DDI-1676105 https://reactome.org/PathwayBrowser/#/R-DDI-1676105 PI(3,5)P2 is dephosphorylated to PI5P by MTM proteins at the early endosome membrane IEA Dictyostelium discoideum DDB_G0269448 R-DDI-1676141 https://reactome.org/PathwayBrowser/#/R-DDI-1676141 PI3P is dephosphorylated to PI by MTM proteins at the early endosome membrane IEA Dictyostelium discoideum DDB_G0269448 R-DDI-1676203 https://reactome.org/PathwayBrowser/#/R-DDI-1676203 PI(3,5)P2 is dephosphorylated to PI5P by SYNJ/MTMs at the plasma membrane IEA Dictyostelium discoideum DDB_G0269448 R-DDI-5679206 https://reactome.org/PathwayBrowser/#/R-DDI-5679206 MTMR14, MTMR3 dephosphorylate PI3P IEA Dictyostelium discoideum DDB_G0269448 R-DDI-6809254 https://reactome.org/PathwayBrowser/#/R-DDI-6809254 MTMR8 binds MTMR9 IEA Dictyostelium discoideum DDB_G0269448 R-DDI-6809309 https://reactome.org/PathwayBrowser/#/R-DDI-6809309 MTMR6 binds MTMR9 IEA Dictyostelium discoideum DDB_G0269448 R-DDI-6809320 https://reactome.org/PathwayBrowser/#/R-DDI-6809320 PI(3,5)P2 is dephosphorylated to PI5P by MTMR9-bound MTMR6 or MTMR8 at the plasma membrane IEA Dictyostelium discoideum DDB_G0269448 R-DDI-6809325 https://reactome.org/PathwayBrowser/#/R-DDI-6809325 PI3P is dephosphorylated to PI by MTMR9-bound MTMR8 or MTMR6 at the plasma membrane IEA Dictyostelium discoideum DDB_G0269448 R-DDI-6809680 https://reactome.org/PathwayBrowser/#/R-DDI-6809680 MTMR12 binds MTM1 IEA Dictyostelium discoideum DDB_G0269448 R-DDI-6809707 https://reactome.org/PathwayBrowser/#/R-DDI-6809707 MTMR12 binds MTMR2 IEA Dictyostelium discoideum DDB_G0269448 R-DDI-6809720 https://reactome.org/PathwayBrowser/#/R-DDI-6809720 PI3P is dephosphorylated to PI by MTM1:MTMR12 IEA Dictyostelium discoideum DDB_G0269448 R-DDI-6809764 https://reactome.org/PathwayBrowser/#/R-DDI-6809764 SBF1 binds MTMR2 IEA Dictyostelium discoideum DDB_G0269448 R-DDI-6809777 https://reactome.org/PathwayBrowser/#/R-DDI-6809777 PI3P is dephosphorylated to PI by MTMR2:SBF1 IEA Dictyostelium discoideum DDB_G0269448 R-DDI-6809778 https://reactome.org/PathwayBrowser/#/R-DDI-6809778 PI(3,5)P2 is dephosphorylated to PI5P by MTMR2:SBF1 IEA Dictyostelium discoideum DDB_G0269448 R-DDI-8876837 https://reactome.org/PathwayBrowser/#/R-DDI-8876837 RAB21 GEFs exchange GTP for GDP on RAB21 IEA Dictyostelium discoideum DDB_G0269458 R-DDI-1022127 https://reactome.org/PathwayBrowser/#/R-DDI-1022127 Ub-unfolded protein:(GlcNAc)2 (Man)9-5 translocates from ERQC to cytosol IEA Dictyostelium discoideum DDB_G0269458 R-DDI-1169397 https://reactome.org/PathwayBrowser/#/R-DDI-1169397 Activation of ISG15 by UBA7 E1 ligase IEA Dictyostelium discoideum DDB_G0269458 R-DDI-1169398 https://reactome.org/PathwayBrowser/#/R-DDI-1169398 ISGylation of host protein filamin B IEA Dictyostelium discoideum DDB_G0269458 R-DDI-1169399 https://reactome.org/PathwayBrowser/#/R-DDI-1169399 Interaction of ISG15 with NEDD4 and inhibition of Ebola virus budding IEA Dictyostelium discoideum DDB_G0269458 R-DDI-1169402 https://reactome.org/PathwayBrowser/#/R-DDI-1169402 ISGylation of E2 conjugating enzymes IEA Dictyostelium discoideum DDB_G0269458 R-DDI-1169403 https://reactome.org/PathwayBrowser/#/R-DDI-1169403 Interaction of E3 ligase with ISG15:E2 complex IEA Dictyostelium discoideum DDB_G0269458 R-DDI-1169404 https://reactome.org/PathwayBrowser/#/R-DDI-1169404 Transfer of ISG15 from E1 to E2 (UBCH8) IEA Dictyostelium discoideum DDB_G0269458 R-DDI-1169406 https://reactome.org/PathwayBrowser/#/R-DDI-1169406 ISGylation of host proteins IEA Dictyostelium discoideum DDB_G0269458 R-DDI-1358789 https://reactome.org/PathwayBrowser/#/R-DDI-1358789 Self-ubiquitination of RNF41 IEA Dictyostelium discoideum DDB_G0269458 R-DDI-1358795 https://reactome.org/PathwayBrowser/#/R-DDI-1358795 Deubiquitination of RNF41 by P-USP8 IEA Dictyostelium discoideum DDB_G0269458 R-DDI-1358797 https://reactome.org/PathwayBrowser/#/R-DDI-1358797 Ubiquitinated RNF41 binds P-USP8 IEA Dictyostelium discoideum DDB_G0269458 R-DDI-1363331 https://reactome.org/PathwayBrowser/#/R-DDI-1363331 Ubiquitination of p130 (RBL2) by SCF (Skp2) IEA Dictyostelium discoideum DDB_G0269458 R-DDI-1504190 https://reactome.org/PathwayBrowser/#/R-DDI-1504190 DVL is ubiquitinated by CUL3:KLHL12:RBX1 IEA Dictyostelium discoideum DDB_G0269458 R-DDI-1504193 https://reactome.org/PathwayBrowser/#/R-DDI-1504193 Ubiquitinated DVL is degraded by the proteasome IEA Dictyostelium discoideum DDB_G0269458 R-DDI-1678842 https://reactome.org/PathwayBrowser/#/R-DDI-1678842 Competitive inhibition of translation initiation by ISGylated 4EHP IEA Dictyostelium discoideum DDB_G0269458 R-DDI-1678843 https://reactome.org/PathwayBrowser/#/R-DDI-1678843 ISGylation of protein translation regulator 4EHP IEA Dictyostelium discoideum DDB_G0269458 R-DDI-174057 https://reactome.org/PathwayBrowser/#/R-DDI-174057 Multiubiquitination of APC/C-associated Cdh1 IEA Dictyostelium discoideum DDB_G0269458 R-DDI-174058 https://reactome.org/PathwayBrowser/#/R-DDI-174058 Degradation of multiubiquitinated Cdh1 IEA Dictyostelium discoideum DDB_G0269458 R-DDI-174104 https://reactome.org/PathwayBrowser/#/R-DDI-174104 Ubiquitination of Cyclin A by APC/C:Cdc20 complex IEA Dictyostelium discoideum DDB_G0269458 R-DDI-174105 https://reactome.org/PathwayBrowser/#/R-DDI-174105 Degradation of multiubiquitinated cell cycle proteins IEA Dictyostelium discoideum DDB_G0269458 R-DDI-174144 https://reactome.org/PathwayBrowser/#/R-DDI-174144 Ubiquitination of Securin by phospho-APC/C:Cdc20 complex IEA Dictyostelium discoideum DDB_G0269458 R-DDI-174195 https://reactome.org/PathwayBrowser/#/R-DDI-174195 Ubiquitination of cell cycle proteins targeted by the APC/C:Cdh1complex IEA Dictyostelium discoideum DDB_G0269458 R-DDI-174202 https://reactome.org/PathwayBrowser/#/R-DDI-174202 Degradation of multiubiquitinated Securin IEA Dictyostelium discoideum DDB_G0269458 R-DDI-174227 https://reactome.org/PathwayBrowser/#/R-DDI-174227 Ubiquitination of Cyclin B by phospho-APC/C:Cdc20 complex IEA Dictyostelium discoideum DDB_G0269458 R-DDI-179417 https://reactome.org/PathwayBrowser/#/R-DDI-179417 Multiubiquitination of Nek2A IEA Dictyostelium discoideum DDB_G0269458 R-DDI-179421 https://reactome.org/PathwayBrowser/#/R-DDI-179421 Degradation of multiubiquitinated Nek2A IEA Dictyostelium discoideum DDB_G0269458 R-DDI-188191 https://reactome.org/PathwayBrowser/#/R-DDI-188191 APC/C:Cdh1-mediated degradation of Skp2 IEA Dictyostelium discoideum DDB_G0269458 R-DDI-264444 https://reactome.org/PathwayBrowser/#/R-DDI-264444 Autoubiquitination of phospho-COP1(Ser-387 ) IEA Dictyostelium discoideum DDB_G0269458 R-DDI-264458 https://reactome.org/PathwayBrowser/#/R-DDI-264458 Proteasome mediated degradation of COP1 IEA Dictyostelium discoideum DDB_G0269458 R-DDI-3788724 https://reactome.org/PathwayBrowser/#/R-DDI-3788724 Cdh1:APC/C ubiquitinates EHMT1 and EHMT2 IEA Dictyostelium discoideum DDB_G0269458 R-DDI-446877 https://reactome.org/PathwayBrowser/#/R-DDI-446877 TRAF6 is K63 poly-ubiquitinated IEA Dictyostelium discoideum DDB_G0269458 R-DDI-450580 https://reactome.org/PathwayBrowser/#/R-DDI-450580 AUF1 (hnRNP D0) is ubiquitinylated IEA Dictyostelium discoideum DDB_G0269458 R-DDI-451418 https://reactome.org/PathwayBrowser/#/R-DDI-451418 Pellino ubiquitinates IRAK1 IEA Dictyostelium discoideum DDB_G0269458 R-DDI-5362412 https://reactome.org/PathwayBrowser/#/R-DDI-5362412 SYVN1 ubiquitinates Hh C-terminal fragments IEA Dictyostelium discoideum DDB_G0269458 R-DDI-5635854 https://reactome.org/PathwayBrowser/#/R-DDI-5635854 GLI2,3 are degraded by the proteasome IEA Dictyostelium discoideum DDB_G0269458 R-DDI-5635856 https://reactome.org/PathwayBrowser/#/R-DDI-5635856 SPOP:CUL3:RBX1 ubiquitinates GLI2,3 IEA Dictyostelium discoideum DDB_G0269458 R-DDI-5652009 https://reactome.org/PathwayBrowser/#/R-DDI-5652009 RAD18:UBE2B or RBX1:CUL4:DDB1:DTL monoubiquitinates PCNA IEA Dictyostelium discoideum DDB_G0269458 R-DDI-5655892 https://reactome.org/PathwayBrowser/#/R-DDI-5655892 POLK incorporates dNMP opposite to damaged DNA base IEA Dictyostelium discoideum DDB_G0269458 R-DDI-5658424 https://reactome.org/PathwayBrowser/#/R-DDI-5658424 KBTBD7:CUL3:RBX1 ubiquitinates NF1 IEA Dictyostelium discoideum DDB_G0269458 R-DDI-5687112 https://reactome.org/PathwayBrowser/#/R-DDI-5687112 MAPK6 is degraded by the 26S proteasome IEA Dictyostelium discoideum DDB_G0269458 R-DDI-5688797 https://reactome.org/PathwayBrowser/#/R-DDI-5688797 ATXN3 family cleave Ub chains IEA Dictyostelium discoideum DDB_G0269458 R-DDI-5689111 https://reactome.org/PathwayBrowser/#/R-DDI-5689111 PARK2 autoubiquitinates IEA Dictyostelium discoideum DDB_G0269458 R-DDI-5689950 https://reactome.org/PathwayBrowser/#/R-DDI-5689950 USP7 deubiquitinates TP53,MDM2,MDM4,FOXO4, PTEN IEA Dictyostelium discoideum DDB_G0269458 R-DDI-5690080 https://reactome.org/PathwayBrowser/#/R-DDI-5690080 USP3,SAGA deubiquitinate Histone H2A,H2B IEA Dictyostelium discoideum DDB_G0269458 R-DDI-5690152 https://reactome.org/PathwayBrowser/#/R-DDI-5690152 USP5 cleaves polyubiquitin IEA Dictyostelium discoideum DDB_G0269458 R-DDI-5690157 https://reactome.org/PathwayBrowser/#/R-DDI-5690157 USP16,USP21 deubiquitinate Histone H2A IEA Dictyostelium discoideum DDB_G0269458 R-DDI-5690159 https://reactome.org/PathwayBrowser/#/R-DDI-5690159 USP21 deubiquitinates RIPK1,DDX58 IEA Dictyostelium discoideum DDB_G0269458 R-DDI-5690319 https://reactome.org/PathwayBrowser/#/R-DDI-5690319 UCHL1, UCHL3 cleave ubiquitin adducts IEA Dictyostelium discoideum DDB_G0269458 R-DDI-5690996 https://reactome.org/PathwayBrowser/#/R-DDI-5690996 ERCC2 and ERCC3 DNA helicases form an open bubble structure in damaged DNA IEA Dictyostelium discoideum DDB_G0269458 R-DDI-5691000 https://reactome.org/PathwayBrowser/#/R-DDI-5691000 TFIIH binds GG-NER site to form a verification complex IEA Dictyostelium discoideum DDB_G0269458 R-DDI-5691001 https://reactome.org/PathwayBrowser/#/R-DDI-5691001 Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in GG-NER IEA Dictyostelium discoideum DDB_G0269458 R-DDI-5691108 https://reactome.org/PathwayBrowser/#/R-DDI-5691108 SKP1:FBXL5:CUL1:NEDD8 ubiquitinylates IREB2 IEA Dictyostelium discoideum DDB_G0269458 R-DDI-5691381 https://reactome.org/PathwayBrowser/#/R-DDI-5691381 MYSM1 deubiquitinates Histone H2A IEA Dictyostelium discoideum DDB_G0269458 R-DDI-5691431 https://reactome.org/PathwayBrowser/#/R-DDI-5691431 PSMD14 cleaves K63-linked ubiquitin IEA Dictyostelium discoideum DDB_G0269458 R-DDI-5696547 https://reactome.org/PathwayBrowser/#/R-DDI-5696547 STAMBPL1 is a deubiquitinase IEA Dictyostelium discoideum DDB_G0269458 R-DDI-5696564 https://reactome.org/PathwayBrowser/#/R-DDI-5696564 USP25 deubiquitinates DDX58 IEA Dictyostelium discoideum DDB_G0269458 R-DDI-5696600 https://reactome.org/PathwayBrowser/#/R-DDI-5696600 USP17 deubiquitinates RCE1, CDC25A, DDX58, IFIH1 IEA Dictyostelium discoideum DDB_G0269458 R-DDI-5696605 https://reactome.org/PathwayBrowser/#/R-DDI-5696605 USP12, USP26 deubiquitinate AR IEA Dictyostelium discoideum DDB_G0269458 R-DDI-5696655 https://reactome.org/PathwayBrowser/#/R-DDI-5696655 PARP1 or PARP2 PARylates DDB2 and autoPARylates IEA Dictyostelium discoideum DDB_G0269458 R-DDI-5696664 https://reactome.org/PathwayBrowser/#/R-DDI-5696664 PARP1 or PARP2 binds DDB2 at GG-NER site IEA Dictyostelium discoideum DDB_G0269458 R-DDI-5696958 https://reactome.org/PathwayBrowser/#/R-DDI-5696958 USP44 deubiquitinates CDC20 IEA Dictyostelium discoideum DDB_G0269458 R-DDI-5696960 https://reactome.org/PathwayBrowser/#/R-DDI-5696960 USP49 deubiquitinates H2B IEA Dictyostelium discoideum DDB_G0269458 R-DDI-6781779 https://reactome.org/PathwayBrowser/#/R-DDI-6781779 USP13 deubiquitinates BECN1,USP10 IEA Dictyostelium discoideum DDB_G0269458 R-DDI-6781814 https://reactome.org/PathwayBrowser/#/R-DDI-6781814 USP19 deubiquitinates RNF123 IEA Dictyostelium discoideum DDB_G0269458 R-DDI-6781867 https://reactome.org/PathwayBrowser/#/R-DDI-6781867 ERCC8:DDB1:CUL4:RBX1 ubiquitinates ERCC6 and RNA Pol II IEA Dictyostelium discoideum DDB_G0269458 R-DDI-6782069 https://reactome.org/PathwayBrowser/#/R-DDI-6782069 UVSSA:USP7 deubiquitinates ERCC6 IEA Dictyostelium discoideum DDB_G0269458 R-DDI-6782131 https://reactome.org/PathwayBrowser/#/R-DDI-6782131 ERCC2-facilitated RNA Pol II backtracking in TC-NER IEA Dictyostelium discoideum DDB_G0269458 R-DDI-6782141 https://reactome.org/PathwayBrowser/#/R-DDI-6782141 Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in TC-NER IEA Dictyostelium discoideum DDB_G0269458 R-DDI-6782204 https://reactome.org/PathwayBrowser/#/R-DDI-6782204 5' incision of damaged DNA strand by ERCC1:ERCC4 in TC-NER IEA Dictyostelium discoideum DDB_G0269458 R-DDI-6782208 https://reactome.org/PathwayBrowser/#/R-DDI-6782208 Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in TC-NER IEA Dictyostelium discoideum DDB_G0269458 R-DDI-6782211 https://reactome.org/PathwayBrowser/#/R-DDI-6782211 DNA polymerases delta, epsilon or kappa bind the TC-NER site IEA Dictyostelium discoideum DDB_G0269458 R-DDI-6782227 https://reactome.org/PathwayBrowser/#/R-DDI-6782227 Ligation of newly synthesized repair patch to incised DNA in TC-NER IEA Dictyostelium discoideum DDB_G0269458 R-DDI-6782820 https://reactome.org/PathwayBrowser/#/R-DDI-6782820 USP17 deubiquitinates SUDS3 IEA Dictyostelium discoideum DDB_G0269458 R-DDI-6782943 https://reactome.org/PathwayBrowser/#/R-DDI-6782943 UV-DDB ubiquitinates XPC IEA Dictyostelium discoideum DDB_G0269458 R-DDI-6783177 https://reactome.org/PathwayBrowser/#/R-DDI-6783177 USP21 deubiquitinates GATA3,IL33 IEA Dictyostelium discoideum DDB_G0269458 R-DDI-6807118 https://reactome.org/PathwayBrowser/#/R-DDI-6807118 USP7 deubiquitinates monoubiquitinated PTEN IEA Dictyostelium discoideum DDB_G0269458 R-DDI-6807134 https://reactome.org/PathwayBrowser/#/R-DDI-6807134 NEDD4, WWP2, CHIP and XIAP polyubiquitinate PTEN IEA Dictyostelium discoideum DDB_G0269458 R-DDI-6807206 https://reactome.org/PathwayBrowser/#/R-DDI-6807206 USP13 and OTUD3 deubiquitinate PTEN IEA Dictyostelium discoideum DDB_G0269458 R-DDI-68946 https://reactome.org/PathwayBrowser/#/R-DDI-68946 Phosphorylated Orc1 is ubiquitinated while still associated with chromatin IEA Dictyostelium discoideum DDB_G0269458 R-DDI-68948 https://reactome.org/PathwayBrowser/#/R-DDI-68948 Ubiquitinated Orc1 is degraded by the proteasome IEA Dictyostelium discoideum DDB_G0269458 R-DDI-69015 https://reactome.org/PathwayBrowser/#/R-DDI-69015 Cytoplasmic phosphorylated Cdc6 is ubiquitinated by the anaphase-promoting complex IEA Dictyostelium discoideum DDB_G0269458 R-DDI-69016 https://reactome.org/PathwayBrowser/#/R-DDI-69016 Ubiquitinated Cdc6 is degraded by the proteasome IEA Dictyostelium discoideum DDB_G0269458 R-DDI-69600 https://reactome.org/PathwayBrowser/#/R-DDI-69600 Proteolytic degradation of ubiquitinated-Cdc25A IEA Dictyostelium discoideum DDB_G0269458 R-DDI-8850992 https://reactome.org/PathwayBrowser/#/R-DDI-8850992 Proteasome degrades polyubiquitinated PTEN IEA Dictyostelium discoideum DDB_G0269458 R-DDI-8852127 https://reactome.org/PathwayBrowser/#/R-DDI-8852127 UBA6 conjugates ubiquitin to cytosolic E2 enzymes IEA Dictyostelium discoideum DDB_G0269458 R-DDI-8852128 https://reactome.org/PathwayBrowser/#/R-DDI-8852128 UBA1 adenylates ubiquitin in the nucleoplasm IEA Dictyostelium discoideum DDB_G0269458 R-DDI-8852129 https://reactome.org/PathwayBrowser/#/R-DDI-8852129 UBA1 conjugates ubiquitin to cytosolic E2 enzymes IEA Dictyostelium discoideum DDB_G0269458 R-DDI-8852130 https://reactome.org/PathwayBrowser/#/R-DDI-8852130 UBA1 conjugates ubiquitin to nuclear E2 enzymes IEA Dictyostelium discoideum DDB_G0269458 R-DDI-8852131 https://reactome.org/PathwayBrowser/#/R-DDI-8852131 Ub-Cys632-UBA1 adenylates ubiquitin in the nucleus IEA Dictyostelium discoideum DDB_G0269458 R-DDI-8852132 https://reactome.org/PathwayBrowser/#/R-DDI-8852132 Ub-Cys632-UBA1 adenylates ubiquitin in the cytosol IEA Dictyostelium discoideum DDB_G0269458 R-DDI-8852133 https://reactome.org/PathwayBrowser/#/R-DDI-8852133 UBA1 conjugates ubiquitin to UBA1 in the cytosol IEA Dictyostelium discoideum DDB_G0269458 R-DDI-8852134 https://reactome.org/PathwayBrowser/#/R-DDI-8852134 UBA1 adenylates ubiquitin in the cytosol IEA Dictyostelium discoideum DDB_G0269458 R-DDI-8852136 https://reactome.org/PathwayBrowser/#/R-DDI-8852136 UBA1 conjugates ubiquitin to UBA1 in the nucleus IEA Dictyostelium discoideum DDB_G0269458 R-DDI-8853379 https://reactome.org/PathwayBrowser/#/R-DDI-8853379 ENGASE hydrolyses unfolded protein:(GlcNAc)2 (Man(9-5) IEA Dictyostelium discoideum DDB_G0269458 R-DDI-8853515 https://reactome.org/PathwayBrowser/#/R-DDI-8853515 OTULIN,USP5 cleaves UBC yielding ubiquitin IEA Dictyostelium discoideum DDB_G0269458 R-DDI-8854041 https://reactome.org/PathwayBrowser/#/R-DDI-8854041 SCF-FBXL7 ubiquitinates AURKA IEA Dictyostelium discoideum DDB_G0269458 R-DDI-8854044 https://reactome.org/PathwayBrowser/#/R-DDI-8854044 Proteasome degrades AURKA ubiquitinated by SCF-FBXL7 IEA Dictyostelium discoideum DDB_G0269458 R-DDI-8866553 https://reactome.org/PathwayBrowser/#/R-DDI-8866553 misfolded CFTR is degraded by the 26S proteasome IEA Dictyostelium discoideum DDB_G0269458 R-DDI-8938770 https://reactome.org/PathwayBrowser/#/R-DDI-8938770 RNF144A binds PRKDC and Ubiquitin:UBE2L3 IEA Dictyostelium discoideum DDB_G0269458 R-DDI-8938773 https://reactome.org/PathwayBrowser/#/R-DDI-8938773 RNF144A polyubiquitinates PRKDC IEA Dictyostelium discoideum DDB_G0269458 R-DDI-8938815 https://reactome.org/PathwayBrowser/#/R-DDI-8938815 RNF152 polyubiquitinates RRAGA IEA Dictyostelium discoideum DDB_G0269458 R-DDI-8938829 https://reactome.org/PathwayBrowser/#/R-DDI-8938829 RNF152 binds RRAGA:GDP and Ubiquitin:UBE2D3 IEA Dictyostelium discoideum DDB_G0269458 R-DDI-8943003 https://reactome.org/PathwayBrowser/#/R-DDI-8943003 SHPRH polyubiquitinates monoubiquitinated PCNA IEA Dictyostelium discoideum DDB_G0269458 R-DDI-8943007 https://reactome.org/PathwayBrowser/#/R-DDI-8943007 SHPRH binds monoUb-K164-PCNA, RAD6:RAD18, UBE2V2:Ub:UBE2N IEA Dictyostelium discoideum DDB_G0269458 R-DDI-8948775 https://reactome.org/PathwayBrowser/#/R-DDI-8948775 MKRN1 polyubiquitinates PTEN IEA Dictyostelium discoideum DDB_G0269458 R-DDI-8953917 https://reactome.org/PathwayBrowser/#/R-DDI-8953917 PEX2:PEX10:PEX12 binds PEX5S,L (in PEX5S:PEX13:PEX14) and Ub:UBE2D1,2,3 IEA Dictyostelium discoideum DDB_G0269458 R-DDI-8953946 https://reactome.org/PathwayBrowser/#/R-DDI-8953946 PEX2:PEX10:PEX12 monoubiquitinates PEX5S,L at cysteine-11 IEA Dictyostelium discoideum DDB_G0269458 R-DDI-9033485 https://reactome.org/PathwayBrowser/#/R-DDI-9033485 PEX2:PEX10:PEX12 monoubiquitinates PEX5L at cysteine-11 IEA Dictyostelium discoideum DDB_G0269458 R-DDI-9033491 https://reactome.org/PathwayBrowser/#/R-DDI-9033491 USP9X hydrolyzes Ub:PEX5L yielding PEX5L and Ubiquitin IEA Dictyostelium discoideum DDB_G0269458 R-DDI-9033509 https://reactome.org/PathwayBrowser/#/R-DDI-9033509 USP9X binds Ub:PEX5L IEA Dictyostelium discoideum DDB_G0269458 R-DDI-9033527 https://reactome.org/PathwayBrowser/#/R-DDI-9033527 PEX2:PEX10:PEX12 binds PEX5L (in PEX5L:PEX7:PEX13:PEX14:PEX2:PEX10:PEX12) and Ub:UBE2D1,2,3 IEA Dictyostelium discoideum DDB_G0269458 R-DDI-917693 https://reactome.org/PathwayBrowser/#/R-DDI-917693 ESCRT Disassembly IEA Dictyostelium discoideum DDB_G0269458 R-DDI-917696 https://reactome.org/PathwayBrowser/#/R-DDI-917696 Cargo Sequestration IEA Dictyostelium discoideum DDB_G0269458 R-DDI-917700 https://reactome.org/PathwayBrowser/#/R-DDI-917700 MVB Vesicle Formation IEA Dictyostelium discoideum DDB_G0269458 R-DDI-936390 https://reactome.org/PathwayBrowser/#/R-DDI-936390 CYLD mediated deubiquitination of DDX58 (RIG-I) IEA Dictyostelium discoideum DDB_G0269458 R-DDI-936563 https://reactome.org/PathwayBrowser/#/R-DDI-936563 ISGylation of DDX58 IEA Dictyostelium discoideum DDB_G0269458 R-DDI-9641089 https://reactome.org/PathwayBrowser/#/R-DDI-9641089 Parkin binds Ub:UBE2N:UBE2V1 IEA Dictyostelium discoideum DDB_G0269458 R-DDI-9641096 https://reactome.org/PathwayBrowser/#/R-DDI-9641096 Misfolded proteins bind PRKN:UBE2N:UBE2V1:Ub IEA Dictyostelium discoideum DDB_G0269458 R-DDI-9641109 https://reactome.org/PathwayBrowser/#/R-DDI-9641109 PolyUb:misfolded proteins dissociate from PRKN:UBE2N:UBE2V1 IEA Dictyostelium discoideum DDB_G0269458 R-DDI-9641111 https://reactome.org/PathwayBrowser/#/R-DDI-9641111 Parkin transfers Ub to misfolded proteins IEA Dictyostelium discoideum DDB_G0269458 R-DDI-9641127 https://reactome.org/PathwayBrowser/#/R-DDI-9641127 Ub:misfolded proteins polymerize to PolyUb:misfolded proteins IEA Dictyostelium discoideum DDB_G0269458 R-DDI-9646348 https://reactome.org/PathwayBrowser/#/R-DDI-9646348 PolyUb-Misfolded Proteins:HDAC6 bind dynein motor IEA Dictyostelium discoideum DDB_G0269458 R-DDI-9646685 https://reactome.org/PathwayBrowser/#/R-DDI-9646685 Aggresome dissociates from dynein and microtubule IEA Dictyostelium discoideum DDB_G0269458 R-DDI-9664888 https://reactome.org/PathwayBrowser/#/R-DDI-9664888 ATM dimer:p-PEX5 ubiquitinates to form ATM dimer:Ub-p-PEX5 IEA Dictyostelium discoideum DDB_G0269458 R-DDI-9684118 https://reactome.org/PathwayBrowser/#/R-DDI-9684118 ERCC3-facilitated RNA Pol II backtracking in TC-NER IEA Dictyostelium discoideum DDB_G0269458 R-DDI-9686969 https://reactome.org/PathwayBrowser/#/R-DDI-9686969 APC/C:Cdh1 polyubiquitinates SKP2 IEA Dictyostelium discoideum DDB_G0269458 R-DDI-9750942 https://reactome.org/PathwayBrowser/#/R-DDI-9750942 USP14 deubiquitinates NLRC5 IEA Dictyostelium discoideum DDB_G0269458 R-DDI-9755306 https://reactome.org/PathwayBrowser/#/R-DDI-9755306 ub UBXN7 is degraded by the 26S proteasome IEA Dictyostelium discoideum DDB_G0269458 R-DDI-9755505 https://reactome.org/PathwayBrowser/#/R-DDI-9755505 KEAP1:NEDD8-CUL3:RBX1 complex ubiquitinates NFE2L2 IEA Dictyostelium discoideum DDB_G0269458 R-DDI-9759172 https://reactome.org/PathwayBrowser/#/R-DDI-9759172 KEAP1:CUL3:RBX1 ubiquitinates p-S349 SQSTM1 oligomer IEA Dictyostelium discoideum DDB_G0269458 R-DDI-9766645 https://reactome.org/PathwayBrowser/#/R-DDI-9766645 CUL3:RBX1 ubiquitinates KEAP1 IEA Dictyostelium discoideum DDB_G0269458 R-DDI-9793472 https://reactome.org/PathwayBrowser/#/R-DDI-9793472 RIPK3 binds p-S9-PRKN IEA Dictyostelium discoideum DDB_G0269458 R-DDI-9793485 https://reactome.org/PathwayBrowser/#/R-DDI-9793485 PRKN polyubiquitinates RIPK3 IEA Dictyostelium discoideum DDB_G0269458 R-DDI-983140 https://reactome.org/PathwayBrowser/#/R-DDI-983140 Transfer of Ub from E2 to substrate and release of E2 IEA Dictyostelium discoideum DDB_G0269458 R-DDI-983150 https://reactome.org/PathwayBrowser/#/R-DDI-983150 Proteasomal cleavage of substrate IEA Dictyostelium discoideum DDB_G0269458 R-DDI-983152 https://reactome.org/PathwayBrowser/#/R-DDI-983152 Transfer of ubiquitin from E1 to E2 IEA Dictyostelium discoideum DDB_G0269458 R-DDI-983153 https://reactome.org/PathwayBrowser/#/R-DDI-983153 E1 mediated ubiquitin activation IEA Dictyostelium discoideum DDB_G0269458 R-DDI-983156 https://reactome.org/PathwayBrowser/#/R-DDI-983156 Polyubiquitination of substrate IEA Dictyostelium discoideum DDB_G0269458 R-DDI-983157 https://reactome.org/PathwayBrowser/#/R-DDI-983157 Interaction of E3 with substrate and E2-Ub complex IEA Dictyostelium discoideum DDB_G0269458 R-DDI-9861640 https://reactome.org/PathwayBrowser/#/R-DDI-9861640 CTLH E3 ligase ubiquitinates PKM-1 IEA Dictyostelium discoideum DDB_G0269472 R-DDI-1236970 https://reactome.org/PathwayBrowser/#/R-DDI-1236970 Proteasomal clevage of exogenous antigen (26S proteasome catalyst) IEA Dictyostelium discoideum DDB_G0269472 R-DDI-1504193 https://reactome.org/PathwayBrowser/#/R-DDI-1504193 Ubiquitinated DVL is degraded by the proteasome IEA Dictyostelium discoideum DDB_G0269472 R-DDI-174058 https://reactome.org/PathwayBrowser/#/R-DDI-174058 Degradation of multiubiquitinated Cdh1 IEA Dictyostelium discoideum DDB_G0269472 R-DDI-174105 https://reactome.org/PathwayBrowser/#/R-DDI-174105 Degradation of multiubiquitinated cell cycle proteins IEA Dictyostelium discoideum DDB_G0269472 R-DDI-174202 https://reactome.org/PathwayBrowser/#/R-DDI-174202 Degradation of multiubiquitinated Securin IEA Dictyostelium discoideum DDB_G0269472 R-DDI-188191 https://reactome.org/PathwayBrowser/#/R-DDI-188191 APC/C:Cdh1-mediated degradation of Skp2 IEA Dictyostelium discoideum DDB_G0269472 R-DDI-264458 https://reactome.org/PathwayBrowser/#/R-DDI-264458 Proteasome mediated degradation of COP1 IEA Dictyostelium discoideum DDB_G0269472 R-DDI-450466 https://reactome.org/PathwayBrowser/#/R-DDI-450466 AUF1:mRNA complex is destroyed IEA Dictyostelium discoideum DDB_G0269472 R-DDI-5635854 https://reactome.org/PathwayBrowser/#/R-DDI-5635854 GLI2,3 are degraded by the proteasome IEA Dictyostelium discoideum DDB_G0269472 R-DDI-5658430 https://reactome.org/PathwayBrowser/#/R-DDI-5658430 NF1 is degraded by the proteasome IEA Dictyostelium discoideum DDB_G0269472 R-DDI-5665854 https://reactome.org/PathwayBrowser/#/R-DDI-5665854 ADRM1:26S proteaseome binds UCHL5 IEA Dictyostelium discoideum DDB_G0269472 R-DDI-5665871 https://reactome.org/PathwayBrowser/#/R-DDI-5665871 ADRM1 binds 26S proteasome IEA Dictyostelium discoideum DDB_G0269472 R-DDI-5687112 https://reactome.org/PathwayBrowser/#/R-DDI-5687112 MAPK6 is degraded by the 26S proteasome IEA Dictyostelium discoideum DDB_G0269472 R-DDI-5689539 https://reactome.org/PathwayBrowser/#/R-DDI-5689539 ADRM1:26S proteaseome binds USP14 IEA Dictyostelium discoideum DDB_G0269472 R-DDI-68948 https://reactome.org/PathwayBrowser/#/R-DDI-68948 Ubiquitinated Orc1 is degraded by the proteasome IEA Dictyostelium discoideum DDB_G0269472 R-DDI-69016 https://reactome.org/PathwayBrowser/#/R-DDI-69016 Ubiquitinated Cdc6 is degraded by the proteasome IEA Dictyostelium discoideum DDB_G0269472 R-DDI-69600 https://reactome.org/PathwayBrowser/#/R-DDI-69600 Proteolytic degradation of ubiquitinated-Cdc25A IEA Dictyostelium discoideum DDB_G0269472 R-DDI-8850992 https://reactome.org/PathwayBrowser/#/R-DDI-8850992 Proteasome degrades polyubiquitinated PTEN IEA Dictyostelium discoideum DDB_G0269472 R-DDI-8854044 https://reactome.org/PathwayBrowser/#/R-DDI-8854044 Proteasome degrades AURKA ubiquitinated by SCF-FBXL7 IEA Dictyostelium discoideum DDB_G0269472 R-DDI-8866553 https://reactome.org/PathwayBrowser/#/R-DDI-8866553 misfolded CFTR is degraded by the 26S proteasome IEA Dictyostelium discoideum DDB_G0269472 R-DDI-9755306 https://reactome.org/PathwayBrowser/#/R-DDI-9755306 ub UBXN7 is degraded by the 26S proteasome IEA Dictyostelium discoideum DDB_G0269472 R-DDI-983150 https://reactome.org/PathwayBrowser/#/R-DDI-983150 Proteasomal cleavage of substrate IEA Dictyostelium discoideum DDB_G0269472 R-DDI-9907919 https://reactome.org/PathwayBrowser/#/R-DDI-9907919 Formation of the preholoproteasome IEA Dictyostelium discoideum DDB_G0269472 R-DDI-9908178 https://reactome.org/PathwayBrowser/#/R-DDI-9908178 Formation of the 26S proteasome IEA Dictyostelium discoideum DDB_G0269472 R-DDI-9908709 https://reactome.org/PathwayBrowser/#/R-DDI-9908709 Formation of the PA28-alpha-beta-20S proteasome IEA Dictyostelium discoideum DDB_G0269472 R-DDI-9908721 https://reactome.org/PathwayBrowser/#/R-DDI-9908721 Formation of the PA28gamma-20S proteasome IEA Dictyostelium discoideum DDB_G0269474 R-DDI-201035 https://reactome.org/PathwayBrowser/#/R-DDI-201035 ACSL1,3,5,6 ligate CoA to PALM to form PALM-CoA IEA Dictyostelium discoideum DDB_G0269474 R-DDI-2046085 https://reactome.org/PathwayBrowser/#/R-DDI-2046085 Activation of alpha-linolenic acid to alpha-linolenoyl-CoA IEA Dictyostelium discoideum DDB_G0269474 R-DDI-2046098 https://reactome.org/PathwayBrowser/#/R-DDI-2046098 Activation of linoleic acid to linoleoyl-CoA IEA Dictyostelium discoideum DDB_G0269496 R-DDI-9013144 https://reactome.org/PathwayBrowser/#/R-DDI-9013144 RAC1 GAPs stimulate RAC1 GTPase activity IEA Dictyostelium discoideum DDB_G0269496 R-DDI-9013161 https://reactome.org/PathwayBrowser/#/R-DDI-9013161 CDC42 GAPs stimulate CDC42 GTPase activity IEA Dictyostelium discoideum DDB_G0269496 R-DDI-9014295 https://reactome.org/PathwayBrowser/#/R-DDI-9014295 RAC2 GAPs stimulate RAC2 GTPase activity IEA Dictyostelium discoideum DDB_G0269496 R-DDI-9017488 https://reactome.org/PathwayBrowser/#/R-DDI-9017488 RHOJ GAPs stimulate RHOJ GTPase activity IEA Dictyostelium discoideum DDB_G0269496 R-DDI-9018745 https://reactome.org/PathwayBrowser/#/R-DDI-9018745 RHOQ GAPs stimulate RHOQ GTPase activity IEA Dictyostelium discoideum DDB_G0269496 R-DDI-9018746 https://reactome.org/PathwayBrowser/#/R-DDI-9018746 RHOQ binds effectors at the plasma membrane IEA Dictyostelium discoideum DDB_G0269496 R-DDI-9018806 https://reactome.org/PathwayBrowser/#/R-DDI-9018806 RAC3 GAPs stimulate RAC3 GTPase activity IEA Dictyostelium discoideum DDB_G0269510 R-DDI-917696 https://reactome.org/PathwayBrowser/#/R-DDI-917696 Cargo Sequestration IEA Dictyostelium discoideum DDB_G0269550 R-DDI-9714477 https://reactome.org/PathwayBrowser/#/R-DDI-9714477 RAC2 binds effectors at the mitochondrial outer membrane IEA Dictyostelium discoideum DDB_G0269570 R-DDI-6801101 https://reactome.org/PathwayBrowser/#/R-DDI-6801101 RABGGTA binds RABGGTB IEA Dictyostelium discoideum DDB_G0269570 R-DDI-6801109 https://reactome.org/PathwayBrowser/#/R-DDI-6801109 CHM binds RGGT IEA Dictyostelium discoideum DDB_G0269570 R-DDI-8870461 https://reactome.org/PathwayBrowser/#/R-DDI-8870461 RABGGTA and RABGGTB bind IEA Dictyostelium discoideum DDB_G0269570 R-DDI-8870465 https://reactome.org/PathwayBrowser/#/R-DDI-8870465 RGGT binds the RAB-binding subunit IEA Dictyostelium discoideum DDB_G0269570 R-DDI-8870466 https://reactome.org/PathwayBrowser/#/R-DDI-8870466 RGGT:CHM binds RABs IEA Dictyostelium discoideum DDB_G0269570 R-DDI-8870469 https://reactome.org/PathwayBrowser/#/R-DDI-8870469 RGGT geranylgeranylates RAB proteins IEA Dictyostelium discoideum DDB_G0269584 R-DDI-204008 https://reactome.org/PathwayBrowser/#/R-DDI-204008 SEC31:SEC13 and v-SNARE recruitment IEA Dictyostelium discoideum DDB_G0269584 R-DDI-5694409 https://reactome.org/PathwayBrowser/#/R-DDI-5694409 Nucleotide exchange on RAB1 IEA Dictyostelium discoideum DDB_G0269584 R-DDI-5694439 https://reactome.org/PathwayBrowser/#/R-DDI-5694439 COPII coat binds TRAPPCII and RAB1:GDP IEA Dictyostelium discoideum DDB_G0269584 R-DDI-5694441 https://reactome.org/PathwayBrowser/#/R-DDI-5694441 CSNK1D phosphorylates SEC23 IEA Dictyostelium discoideum DDB_G0269584 R-DDI-6786650 https://reactome.org/PathwayBrowser/#/R-DDI-6786650 DDHD1,2 hydrolyse PA IEA Dictyostelium discoideum DDB_G0269584 R-DDI-8869241 https://reactome.org/PathwayBrowser/#/R-DDI-8869241 PITPNM1,2,3 exchange PI for PA IEA Dictyostelium discoideum DDB_G0269600 R-DDI-481007 https://reactome.org/PathwayBrowser/#/R-DDI-481007 Exocytosis of platelet alpha granule contents IEA Dictyostelium discoideum DDB_G0269602 R-DDI-741449 https://reactome.org/PathwayBrowser/#/R-DDI-741449 SLC35B2,3 transport cytosolic PAPS to Golgi lumen IEA Dictyostelium discoideum DDB_G0269614 R-DDI-3371503 https://reactome.org/PathwayBrowser/#/R-DDI-3371503 STIP1(HOP) binds HSP90 and HSP70:HSP40:nascent protein IEA Dictyostelium discoideum DDB_G0269614 R-DDI-5618107 https://reactome.org/PathwayBrowser/#/R-DDI-5618107 ATP binding to HSP90 triggers conformation change IEA Dictyostelium discoideum DDB_G0269624 R-DDI-9013144 https://reactome.org/PathwayBrowser/#/R-DDI-9013144 RAC1 GAPs stimulate RAC1 GTPase activity IEA Dictyostelium discoideum DDB_G0269624 R-DDI-9013161 https://reactome.org/PathwayBrowser/#/R-DDI-9013161 CDC42 GAPs stimulate CDC42 GTPase activity IEA Dictyostelium discoideum DDB_G0269624 R-DDI-9014295 https://reactome.org/PathwayBrowser/#/R-DDI-9014295 RAC2 GAPs stimulate RAC2 GTPase activity IEA Dictyostelium discoideum DDB_G0269624 R-DDI-9018806 https://reactome.org/PathwayBrowser/#/R-DDI-9018806 RAC3 GAPs stimulate RAC3 GTPase activity IEA Dictyostelium discoideum DDB_G0269646 R-DDI-5688797 https://reactome.org/PathwayBrowser/#/R-DDI-5688797 ATXN3 family cleave Ub chains IEA Dictyostelium discoideum DDB_G0269678 R-DDI-6787540 https://reactome.org/PathwayBrowser/#/R-DDI-6787540 FUK phosphorylates beta-Fuc to Fuc1P IEA Dictyostelium discoideum DDB_G0269680 R-DDI-9639287 https://reactome.org/PathwayBrowser/#/R-DDI-9639287 SESN1,2 binds L-leucine and dissociates from GATOR2 IEA Dictyostelium discoideum DDB_G0269680 R-DDI-9640195 https://reactome.org/PathwayBrowser/#/R-DDI-9640195 RRAGA,B hydrolyzes GTP IEA Dictyostelium discoideum DDB_G0269686 R-DDI-8952638 https://reactome.org/PathwayBrowser/#/R-DDI-8952638 AcM-UBE2M transfers NEDD8 to CRL4 E3 ubiquitin ligase complex IEA Dictyostelium discoideum DDB_G0269686 R-DDI-8952639 https://reactome.org/PathwayBrowser/#/R-DDI-8952639 NEDD8:AcM-UBE2M binds CRL4 E3 ubiquitin ligase complex IEA Dictyostelium discoideum DDB_G0269686 R-DDI-8955245 https://reactome.org/PathwayBrowser/#/R-DDI-8955245 CAND1 binds CRL4 E3 ubiquitin ligase in the nucleus IEA Dictyostelium discoideum DDB_G0269686 R-DDI-8955285 https://reactome.org/PathwayBrowser/#/R-DDI-8955285 COMMDs displace CAND1 from CRL4 E3 ubiquitin ligase complex IEA Dictyostelium discoideum DDB_G0269686 R-DDI-8956045 https://reactome.org/PathwayBrowser/#/R-DDI-8956045 COP9 signalosome deneddylates nuclear CRL4 E3 ubiquitin ligase complex IEA Dictyostelium discoideum DDB_G0269692 R-DDI-5693578 https://reactome.org/PathwayBrowser/#/R-DDI-5693578 TDP1 and TDP2 process unligatable DSB ends IEA Dictyostelium discoideum DDB_G0269696 R-DDI-389788 https://reactome.org/PathwayBrowser/#/R-DDI-389788 Activation of PAKs by RAC1 and CDC42 IEA Dictyostelium discoideum DDB_G0269696 R-DDI-5627775 https://reactome.org/PathwayBrowser/#/R-DDI-5627775 Autophosphorylation of PAK1,2,3 IEA Dictyostelium discoideum DDB_G0269696 R-DDI-5668932 https://reactome.org/PathwayBrowser/#/R-DDI-5668932 PAK2 phosphorylates myosin regulatory light chain (MRLC) IEA Dictyostelium discoideum DDB_G0269696 R-DDI-5687086 https://reactome.org/PathwayBrowser/#/R-DDI-5687086 PAK1,2,3 phosphorylates MAPK6,4 IEA Dictyostelium discoideum DDB_G0269696 R-DDI-8981926 https://reactome.org/PathwayBrowser/#/R-DDI-8981926 RAC1 and CDC42 activate PAK3 IEA Dictyostelium discoideum DDB_G0269696 R-DDI-8981931 https://reactome.org/PathwayBrowser/#/R-DDI-8981931 RAC1 and CDC42 activate PAK2 IEA Dictyostelium discoideum DDB_G0269696 R-DDI-9013145 https://reactome.org/PathwayBrowser/#/R-DDI-9013145 RAC1 binds effectors at the plasma membrane IEA Dictyostelium discoideum DDB_G0269696 R-DDI-9014294 https://reactome.org/PathwayBrowser/#/R-DDI-9014294 RAC2 binds effectors at the plasma membrane IEA Dictyostelium discoideum DDB_G0269696 R-DDI-9014449 https://reactome.org/PathwayBrowser/#/R-DDI-9014449 RHOG binds effectors at the plasma membrane IEA Dictyostelium discoideum DDB_G0269696 R-DDI-9018746 https://reactome.org/PathwayBrowser/#/R-DDI-9018746 RHOQ binds effectors at the plasma membrane IEA Dictyostelium discoideum DDB_G0269696 R-DDI-9018758 https://reactome.org/PathwayBrowser/#/R-DDI-9018758 RHOH binds effectors at the plasma membrane IEA Dictyostelium discoideum DDB_G0269696 R-DDI-9018766 https://reactome.org/PathwayBrowser/#/R-DDI-9018766 RHOU binds effectors at the plasma membrane IEA Dictyostelium discoideum DDB_G0269696 R-DDI-9018794 https://reactome.org/PathwayBrowser/#/R-DDI-9018794 RHOV binds effectors at the plasma membrane IEA Dictyostelium discoideum DDB_G0269696 R-DDI-9018808 https://reactome.org/PathwayBrowser/#/R-DDI-9018808 RAC3 binds effectors at the plasma membrane IEA Dictyostelium discoideum DDB_G0269704 R-DDI-983140 https://reactome.org/PathwayBrowser/#/R-DDI-983140 Transfer of Ub from E2 to substrate and release of E2 IEA Dictyostelium discoideum DDB_G0269704 R-DDI-983147 https://reactome.org/PathwayBrowser/#/R-DDI-983147 Release of E3 from polyubiquitinated substrate IEA Dictyostelium discoideum DDB_G0269704 R-DDI-983156 https://reactome.org/PathwayBrowser/#/R-DDI-983156 Polyubiquitination of substrate IEA Dictyostelium discoideum DDB_G0269704 R-DDI-983157 https://reactome.org/PathwayBrowser/#/R-DDI-983157 Interaction of E3 with substrate and E2-Ub complex IEA Dictyostelium discoideum DDB_G0269714 R-DDI-71188 https://reactome.org/PathwayBrowser/#/R-DDI-71188 TDO tetramer dioxygenates L-Trp to NFK IEA Dictyostelium discoideum DDB_G0269720 R-DDI-1467457 https://reactome.org/PathwayBrowser/#/R-DDI-1467457 ABCA8,B1,B5 transport xenobiotics from cytosol to extracellular region IEA Dictyostelium discoideum DDB_G0269720 R-DDI-193362 https://reactome.org/PathwayBrowser/#/R-DDI-193362 ABCB11 transports bile salts from cytosol to extracellular region IEA Dictyostelium discoideum DDB_G0269720 R-DDI-382560 https://reactome.org/PathwayBrowser/#/R-DDI-382560 ABC7, mABC1 and mABC2 mediate heme transport IEA Dictyostelium discoideum DDB_G0269720 R-DDI-5678706 https://reactome.org/PathwayBrowser/#/R-DDI-5678706 ABCB4 transports PC from plasma membrane to extracellular region IEA Dictyostelium discoideum DDB_G0269720 R-DDI-9659680 https://reactome.org/PathwayBrowser/#/R-DDI-9659680 ABCB1 transports xenobiotics out of the cell IEA Dictyostelium discoideum DDB_G0269720 R-DDI-9757139 https://reactome.org/PathwayBrowser/#/R-DDI-9757139 ABCB1,ABCC2 transport ATVs from cytosol to extracellular region IEA Dictyostelium discoideum DDB_G0269720 R-DDI-9759454 https://reactome.org/PathwayBrowser/#/R-DDI-9759454 ABCB1 transports PREDN,PREDL out of kidney cells IEA Dictyostelium discoideum DDB_G0269720 R-DDI-9759461 https://reactome.org/PathwayBrowser/#/R-DDI-9759461 ABCB1 transports PREDN,PREDL out of hepatic cells IEA Dictyostelium discoideum DDB_G0269736 R-DDI-391266 https://reactome.org/PathwayBrowser/#/R-DDI-391266 Association of CCT/TriC with sphingosine kinase 1 IEA Dictyostelium discoideum DDB_G0269736 R-DDI-6814119 https://reactome.org/PathwayBrowser/#/R-DDI-6814119 TRiC/CCT binds unfolded G-protein beta subunit IEA Dictyostelium discoideum DDB_G0269736 R-DDI-6814120 https://reactome.org/PathwayBrowser/#/R-DDI-6814120 ATP hydrolysis promotes folding of G-protein beta by TRiC/CCT IEA Dictyostelium discoideum DDB_G0269736 R-DDI-6814124 https://reactome.org/PathwayBrowser/#/R-DDI-6814124 ATP binds G-protein beta associated TRiC/CCT IEA Dictyostelium discoideum DDB_G0269738 R-DDI-428259 https://reactome.org/PathwayBrowser/#/R-DDI-428259 DEGS1 dehydrogenates dihydroceramide IEA Dictyostelium discoideum DDB_G0269738 R-DDI-428260 https://reactome.org/PathwayBrowser/#/R-DDI-428260 DEGS2 oxygenates dihydroceramide IEA Dictyostelium discoideum DDB_G0269738 R-DDI-6799350 https://reactome.org/PathwayBrowser/#/R-DDI-6799350 Exocytosis of specific granule membrane proteins IEA Dictyostelium discoideum DDB_G0269742 R-DDI-1483121 https://reactome.org/PathwayBrowser/#/R-DDI-1483121 PA is converted to CDP-DAG by CDS1 IEA Dictyostelium discoideum DDB_G0269742 R-DDI-1483165 https://reactome.org/PathwayBrowser/#/R-DDI-1483165 PA is converted to CDP-DAG by CDS2 IEA Dictyostelium discoideum DDB_G0269746 R-DDI-1855159 https://reactome.org/PathwayBrowser/#/R-DDI-1855159 I(1,3,4,6)P4 is dephosphorylated to I(3,4,6)P3 by ITPK1 in the cytosol IEA Dictyostelium discoideum DDB_G0269746 R-DDI-1855162 https://reactome.org/PathwayBrowser/#/R-DDI-1855162 I(3,4,5,6)P4 is phosphorylated to I(1,3,4,5,6)P5 by ITPK1 in the cytosol IEA Dictyostelium discoideum DDB_G0269746 R-DDI-1855169 https://reactome.org/PathwayBrowser/#/R-DDI-1855169 I(3,4,6)P3 is phosphorylated to I(1,3,4,6)P4 by ITPK1 in the cytosol IEA Dictyostelium discoideum DDB_G0269746 R-DDI-1855171 https://reactome.org/PathwayBrowser/#/R-DDI-1855171 I(1,3,4,6)P4 is dephosphorylated to I(1,3,4)P3 by ITPK1 in the cytosol IEA Dictyostelium discoideum DDB_G0269746 R-DDI-1855172 https://reactome.org/PathwayBrowser/#/R-DDI-1855172 I(1,3,4)P3 is phosphorylated to I(1,3,4,5)P4 by ITPK1 in the cytosol IEA Dictyostelium discoideum DDB_G0269746 R-DDI-1855197 https://reactome.org/PathwayBrowser/#/R-DDI-1855197 I(1,3,4)P3 is phosphorylated to I(1,3,4,6)P4 by ITPK1 in the cytosol IEA Dictyostelium discoideum DDB_G0269746 R-DDI-1855218 https://reactome.org/PathwayBrowser/#/R-DDI-1855218 I(1,3,4,5)P4 is dephosphorylated to I(1,3,4)P3 by INPP5[3]/ITPK1 in the cytosol IEA Dictyostelium discoideum DDB_G0269746 R-DDI-1855219 https://reactome.org/PathwayBrowser/#/R-DDI-1855219 I(1,3,4,5,6)P5 is dephosphorylated to I(3,4,5,6)P4 by ITPK1 in the cytosol IEA Dictyostelium discoideum DDB_G0269746 R-DDI-2267372 https://reactome.org/PathwayBrowser/#/R-DDI-2267372 ITPK1 converts Ins-1,3,4-P3 to Ins-1,3,4,6-P4 IEA Dictyostelium discoideum DDB_G0269746 R-DDI-994137 https://reactome.org/PathwayBrowser/#/R-DDI-994137 ITPK1 converts Ins-3,4,5,6-P4 to Ins-1,3,4,5,6-P5 IEA Dictyostelium discoideum DDB_G0269746 R-DDI-994140 https://reactome.org/PathwayBrowser/#/R-DDI-994140 ITPK1 converts Ins-1,3,4-P3 to Ins-1,3,4,5-P4 IEA Dictyostelium discoideum DDB_G0269768 R-DDI-5159245 https://reactome.org/PathwayBrowser/#/R-DDI-5159245 SETD3, SETD7 (KMT7), WHSC1L1 (KMT3F), Core MLL complex methylate lysine-5 of histone H3 (H3K4) IEA Dictyostelium discoideum DDB_G0269768 R-DDI-5637686 https://reactome.org/PathwayBrowser/#/R-DDI-5637686 WHSC1L1 (KMT3F), Core MLL complex, SMYD3 (KMT3E) methylate methyl-lysine-5 of histone H3 (H3K4) IEA Dictyostelium discoideum DDB_G0269772 R-DDI-1236970 https://reactome.org/PathwayBrowser/#/R-DDI-1236970 Proteasomal clevage of exogenous antigen (26S proteasome catalyst) IEA Dictyostelium discoideum DDB_G0269772 R-DDI-1504193 https://reactome.org/PathwayBrowser/#/R-DDI-1504193 Ubiquitinated DVL is degraded by the proteasome IEA Dictyostelium discoideum DDB_G0269772 R-DDI-174058 https://reactome.org/PathwayBrowser/#/R-DDI-174058 Degradation of multiubiquitinated Cdh1 IEA Dictyostelium discoideum DDB_G0269772 R-DDI-174105 https://reactome.org/PathwayBrowser/#/R-DDI-174105 Degradation of multiubiquitinated cell cycle proteins IEA Dictyostelium discoideum DDB_G0269772 R-DDI-174202 https://reactome.org/PathwayBrowser/#/R-DDI-174202 Degradation of multiubiquitinated Securin IEA Dictyostelium discoideum DDB_G0269772 R-DDI-188191 https://reactome.org/PathwayBrowser/#/R-DDI-188191 APC/C:Cdh1-mediated degradation of Skp2 IEA Dictyostelium discoideum DDB_G0269772 R-DDI-264458 https://reactome.org/PathwayBrowser/#/R-DDI-264458 Proteasome mediated degradation of COP1 IEA Dictyostelium discoideum DDB_G0269772 R-DDI-450466 https://reactome.org/PathwayBrowser/#/R-DDI-450466 AUF1:mRNA complex is destroyed IEA Dictyostelium discoideum DDB_G0269772 R-DDI-5635854 https://reactome.org/PathwayBrowser/#/R-DDI-5635854 GLI2,3 are degraded by the proteasome IEA Dictyostelium discoideum DDB_G0269772 R-DDI-5658430 https://reactome.org/PathwayBrowser/#/R-DDI-5658430 NF1 is degraded by the proteasome IEA Dictyostelium discoideum DDB_G0269772 R-DDI-5665854 https://reactome.org/PathwayBrowser/#/R-DDI-5665854 ADRM1:26S proteaseome binds UCHL5 IEA Dictyostelium discoideum DDB_G0269772 R-DDI-5665871 https://reactome.org/PathwayBrowser/#/R-DDI-5665871 ADRM1 binds 26S proteasome IEA Dictyostelium discoideum DDB_G0269772 R-DDI-5687112 https://reactome.org/PathwayBrowser/#/R-DDI-5687112 MAPK6 is degraded by the 26S proteasome IEA Dictyostelium discoideum DDB_G0269772 R-DDI-5689539 https://reactome.org/PathwayBrowser/#/R-DDI-5689539 ADRM1:26S proteaseome binds USP14 IEA Dictyostelium discoideum DDB_G0269772 R-DDI-68948 https://reactome.org/PathwayBrowser/#/R-DDI-68948 Ubiquitinated Orc1 is degraded by the proteasome IEA Dictyostelium discoideum DDB_G0269772 R-DDI-69016 https://reactome.org/PathwayBrowser/#/R-DDI-69016 Ubiquitinated Cdc6 is degraded by the proteasome IEA Dictyostelium discoideum DDB_G0269772 R-DDI-69600 https://reactome.org/PathwayBrowser/#/R-DDI-69600 Proteolytic degradation of ubiquitinated-Cdc25A IEA Dictyostelium discoideum DDB_G0269772 R-DDI-8850992 https://reactome.org/PathwayBrowser/#/R-DDI-8850992 Proteasome degrades polyubiquitinated PTEN IEA Dictyostelium discoideum DDB_G0269772 R-DDI-8854044 https://reactome.org/PathwayBrowser/#/R-DDI-8854044 Proteasome degrades AURKA ubiquitinated by SCF-FBXL7 IEA Dictyostelium discoideum DDB_G0269772 R-DDI-8866553 https://reactome.org/PathwayBrowser/#/R-DDI-8866553 misfolded CFTR is degraded by the 26S proteasome IEA Dictyostelium discoideum DDB_G0269772 R-DDI-9755306 https://reactome.org/PathwayBrowser/#/R-DDI-9755306 ub UBXN7 is degraded by the 26S proteasome IEA Dictyostelium discoideum DDB_G0269772 R-DDI-983150 https://reactome.org/PathwayBrowser/#/R-DDI-983150 Proteasomal cleavage of substrate IEA Dictyostelium discoideum DDB_G0269772 R-DDI-9907919 https://reactome.org/PathwayBrowser/#/R-DDI-9907919 Formation of the preholoproteasome IEA Dictyostelium discoideum DDB_G0269772 R-DDI-9907925 https://reactome.org/PathwayBrowser/#/R-DDI-9907925 Formation of the inner ring of the 20S immunoproteasome core particle IEA Dictyostelium discoideum DDB_G0269772 R-DDI-9907928 https://reactome.org/PathwayBrowser/#/R-DDI-9907928 Formation of the inner ring of the 20S thymoproteasome core particle IEA Dictyostelium discoideum DDB_G0269772 R-DDI-9907940 https://reactome.org/PathwayBrowser/#/R-DDI-9907940 Formation of the preholothymoproteasome IEA Dictyostelium discoideum DDB_G0269772 R-DDI-9907941 https://reactome.org/PathwayBrowser/#/R-DDI-9907941 Fromation of the preholoimmunoproteasome IEA Dictyostelium discoideum DDB_G0269772 R-DDI-9908178 https://reactome.org/PathwayBrowser/#/R-DDI-9908178 Formation of the 26S proteasome IEA Dictyostelium discoideum DDB_G0269772 R-DDI-9908709 https://reactome.org/PathwayBrowser/#/R-DDI-9908709 Formation of the PA28-alpha-beta-20S proteasome IEA Dictyostelium discoideum DDB_G0269772 R-DDI-9908721 https://reactome.org/PathwayBrowser/#/R-DDI-9908721 Formation of the PA28gamma-20S proteasome IEA Dictyostelium discoideum DDB_G0269774 R-DDI-6798751 https://reactome.org/PathwayBrowser/#/R-DDI-6798751 Exocytosis of azurophil granule lumen proteins IEA Dictyostelium discoideum DDB_G0269778 R-DDI-6798044 https://reactome.org/PathwayBrowser/#/R-DDI-6798044 BTG2 binds CCR4-NOT complex IEA Dictyostelium discoideum DDB_G0269788 R-DDI-191983 https://reactome.org/PathwayBrowser/#/R-DDI-191983 Cholesterol is hydroxylated to 25-hydroxycholesterol IEA Dictyostelium discoideum DDB_G0269788 R-DDI-194641 https://reactome.org/PathwayBrowser/#/R-DDI-194641 4,4-dimethylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol IEA Dictyostelium discoideum DDB_G0269788 R-DDI-194669 https://reactome.org/PathwayBrowser/#/R-DDI-194669 4-methylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-carboxycholesta-8(9),24-dien-3beta-ol IEA Dictyostelium discoideum DDB_G0269790 R-DDI-189053 https://reactome.org/PathwayBrowser/#/R-DDI-189053 Digestion of 1-6 linkages of limit dextrins to yield maltose, maltotriose, longer maltosides, and glucose IEA Dictyostelium discoideum DDB_G0269790 R-DDI-189069 https://reactome.org/PathwayBrowser/#/R-DDI-189069 sucrose + H2O => glucose + fructose IEA Dictyostelium discoideum DDB_G0269790 R-DDI-189102 https://reactome.org/PathwayBrowser/#/R-DDI-189102 maltose + H2O => 2 D-glucose (maltase-glucoamylase) IEA Dictyostelium discoideum DDB_G0269790 R-DDI-191101 https://reactome.org/PathwayBrowser/#/R-DDI-191101 maltotriose + H2O => maltose + D-glucose (sucrase-isomaltase) IEA Dictyostelium discoideum DDB_G0269790 R-DDI-191108 https://reactome.org/PathwayBrowser/#/R-DDI-191108 maltose + H2O => 2 D-glucose (sucrase-isomaltase) IEA Dictyostelium discoideum DDB_G0269790 R-DDI-191116 https://reactome.org/PathwayBrowser/#/R-DDI-191116 maltotriose + H2O => maltose + D-glucose (maltase-glucoamylase) IEA Dictyostelium discoideum DDB_G0269790 R-DDI-5659861 https://reactome.org/PathwayBrowser/#/R-DDI-5659861 isomaltose + H2O => 2 D-glucose (sucrase-isomaltase) IEA Dictyostelium discoideum DDB_G0269790 R-DDI-6798739 https://reactome.org/PathwayBrowser/#/R-DDI-6798739 Exocytosis of azurophil granule membrane proteins IEA Dictyostelium discoideum DDB_G0269790 R-DDI-6798747 https://reactome.org/PathwayBrowser/#/R-DDI-6798747 Exocytosis of tertiary granule membrane proteins IEA Dictyostelium discoideum DDB_G0269790 R-DDI-6800426 https://reactome.org/PathwayBrowser/#/R-DDI-6800426 Exocytosis of ficolin-rich granule membrane proteins IEA Dictyostelium discoideum DDB_G0269790 R-DDI-9036727 https://reactome.org/PathwayBrowser/#/R-DDI-9036727 GAA hydrolyzes lysosomal glycogen IEA Dictyostelium discoideum DDB_G0269814 R-DDI-111437 https://reactome.org/PathwayBrowser/#/R-DDI-111437 Cleavage of the 3'-end of the Histone Pre-mRNA IEA Dictyostelium discoideum DDB_G0269814 R-DDI-111438 https://reactome.org/PathwayBrowser/#/R-DDI-111438 Recruitment of U7 snRNP:ZFP100 complex to the Histone Pre-mRNA IEA Dictyostelium discoideum DDB_G0269814 R-DDI-112383 https://reactome.org/PathwayBrowser/#/R-DDI-112383 Hypophosphorylation of RNA Pol II CTD by FCP1P protein IEA Dictyostelium discoideum DDB_G0269814 R-DDI-113407 https://reactome.org/PathwayBrowser/#/R-DDI-113407 DSIF complex binds to RNA Pol II (hypophosphorylated) IEA Dictyostelium discoideum DDB_G0269814 R-DDI-113409 https://reactome.org/PathwayBrowser/#/R-DDI-113409 Abortive termination of early transcription elongation by DSIF:NELF IEA Dictyostelium discoideum DDB_G0269814 R-DDI-6814555 https://reactome.org/PathwayBrowser/#/R-DDI-6814555 Integrator complex processes the 3' end of snRNA IEA Dictyostelium discoideum DDB_G0269814 R-DDI-72103 https://reactome.org/PathwayBrowser/#/R-DDI-72103 Formation of pre-mRNPs IEA Dictyostelium discoideum DDB_G0269814 R-DDI-77094 https://reactome.org/PathwayBrowser/#/R-DDI-77094 Formation of cap binding complex (CBC) IEA Dictyostelium discoideum DDB_G0269814 R-DDI-77095 https://reactome.org/PathwayBrowser/#/R-DDI-77095 Recognition and binding of the mRNA cap by the cap-binding complex IEA Dictyostelium discoideum DDB_G0269814 R-DDI-77584 https://reactome.org/PathwayBrowser/#/R-DDI-77584 Binding of SLBP to Replication-Dependent Histone Pre-mRNA IEA Dictyostelium discoideum DDB_G0269814 R-DDI-77585 https://reactome.org/PathwayBrowser/#/R-DDI-77585 Recruitment of U7 snRNP:ZFP100 complex to the SLBP Bound Pre-mRNA IEA Dictyostelium discoideum DDB_G0269814 R-DDI-77586 https://reactome.org/PathwayBrowser/#/R-DDI-77586 Cleavage of the 3'-end of Replication Dependent Histone Pre-mRNA IEA Dictyostelium discoideum DDB_G0269814 R-DDI-77589 https://reactome.org/PathwayBrowser/#/R-DDI-77589 Recognition of AAUAAA sequence by CPSF IEA Dictyostelium discoideum DDB_G0269814 R-DDI-77590 https://reactome.org/PathwayBrowser/#/R-DDI-77590 Recruitment of CstF to the CPSF Bound Pre-mRNA IEA Dictyostelium discoideum DDB_G0269814 R-DDI-927789 https://reactome.org/PathwayBrowser/#/R-DDI-927789 Formation of UPF1:eRF3 complex on mRNA with a premature termination codon and no Exon Junction Complex IEA Dictyostelium discoideum DDB_G0269814 R-DDI-927832 https://reactome.org/PathwayBrowser/#/R-DDI-927832 UPF1 binds an mRNP with a termination codon preceding an Exon Junction Complex IEA Dictyostelium discoideum DDB_G0269814 R-DDI-927889 https://reactome.org/PathwayBrowser/#/R-DDI-927889 SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex) IEA Dictyostelium discoideum DDB_G0269814 R-DDI-9770236 https://reactome.org/PathwayBrowser/#/R-DDI-9770236 Formation of the Spliceosomal P complex and exon ligation IEA Dictyostelium discoideum DDB_G0269830 R-DDI-6791222 https://reactome.org/PathwayBrowser/#/R-DDI-6791222 21S pre-rRNA is nucleolytically processed at site E (site2a) to yield 18SE pre-rRNA IEA Dictyostelium discoideum DDB_G0269830 R-DDI-6791227 https://reactome.org/PathwayBrowser/#/R-DDI-6791227 47S pre-rRNA is nucleolytically processed at A' (01,A1), site A0, and site 02 (site 6) to yield 45S pre-rRNA IEA Dictyostelium discoideum DDB_G0269848 R-DDI-1482548 https://reactome.org/PathwayBrowser/#/R-DDI-1482548 1-acyl LPA is acylated to PA by AGPAT5 (OM) IEA Dictyostelium discoideum DDB_G0269848 R-DDI-75885 https://reactome.org/PathwayBrowser/#/R-DDI-75885 1-acyl LPA is acylated to PA by AGPAT (LPAAT) IEA Dictyostelium discoideum DDB_G0269854 R-DDI-70906 https://reactome.org/PathwayBrowser/#/R-DDI-70906 4-imidazolone-5-propionate + H2O => N-formiminoglutamate + 2H+ IEA Dictyostelium discoideum DDB_G0269864 R-DDI-1296035 https://reactome.org/PathwayBrowser/#/R-DDI-1296035 Activation of Ca2+ activated Potassium channels with Intermediate conductance IEA Dictyostelium discoideum DDB_G0269864 R-DDI-1296039 https://reactome.org/PathwayBrowser/#/R-DDI-1296039 Activation of Ca2+ activated Potassium channels with small conductance IEA Dictyostelium discoideum DDB_G0269878 R-DDI-6791222 https://reactome.org/PathwayBrowser/#/R-DDI-6791222 21S pre-rRNA is nucleolytically processed at site E (site2a) to yield 18SE pre-rRNA IEA Dictyostelium discoideum DDB_G0269878 R-DDI-6791227 https://reactome.org/PathwayBrowser/#/R-DDI-6791227 47S pre-rRNA is nucleolytically processed at A' (01,A1), site A0, and site 02 (site 6) to yield 45S pre-rRNA IEA Dictyostelium discoideum DDB_G0269890 R-DDI-6806966 https://reactome.org/PathwayBrowser/#/R-DDI-6806966 APOA1BP dimer epimerises R-NAD(P)HX to S-NAD(P)HX IEA Dictyostelium discoideum DDB_G0269894 R-DDI-68595 https://reactome.org/PathwayBrowser/#/R-DDI-68595 ORC2 binds ORC3 IEA Dictyostelium discoideum DDB_G0269894 R-DDI-68603 https://reactome.org/PathwayBrowser/#/R-DDI-68603 ORC5 binds ORC2:ORC3 IEA Dictyostelium discoideum DDB_G0269894 R-DDI-68610 https://reactome.org/PathwayBrowser/#/R-DDI-68610 Formation of ORC(2-5) complex IEA Dictyostelium discoideum DDB_G0269894 R-DDI-68611 https://reactome.org/PathwayBrowser/#/R-DDI-68611 Formation of ORC(1-5) complex IEA Dictyostelium discoideum DDB_G0269894 R-DDI-68615 https://reactome.org/PathwayBrowser/#/R-DDI-68615 Formation of ORC(1-6) complex IEA Dictyostelium discoideum DDB_G0269894 R-DDI-68688 https://reactome.org/PathwayBrowser/#/R-DDI-68688 CDC6 association with ORC(1-6) at replication origins IEA Dictyostelium discoideum DDB_G0269894 R-DDI-68914 https://reactome.org/PathwayBrowser/#/R-DDI-68914 DNA polymerase alpha:primase binds at the origin IEA Dictyostelium discoideum DDB_G0269894 R-DDI-68917 https://reactome.org/PathwayBrowser/#/R-DDI-68917 Cdc45 associates with the pre-replicative complex at the origin IEA Dictyostelium discoideum DDB_G0269894 R-DDI-68960 https://reactome.org/PathwayBrowser/#/R-DDI-68960 DNA polymerase epsilon binds at the origin IEA Dictyostelium discoideum DDB_G0269896 R-DDI-2534365 https://reactome.org/PathwayBrowser/#/R-DDI-2534365 Slo3 Potassium Transport IEA Dictyostelium discoideum DDB_G0269902 R-DDI-2029466 https://reactome.org/PathwayBrowser/#/R-DDI-2029466 (WASPs, WAVE):G-actin:ARP2/3 binds F-actin IEA Dictyostelium discoideum DDB_G0269902 R-DDI-2029473 https://reactome.org/PathwayBrowser/#/R-DDI-2029473 Branching and elongation of mother and daughter filaments IEA Dictyostelium discoideum DDB_G0269902 R-DDI-2197690 https://reactome.org/PathwayBrowser/#/R-DDI-2197690 Detachment of WASP/WAVE IEA Dictyostelium discoideum DDB_G0269902 R-DDI-430347 https://reactome.org/PathwayBrowser/#/R-DDI-430347 MigFilin associates with Filamin and F-actin IEA Dictyostelium discoideum DDB_G0269902 R-DDI-482772 https://reactome.org/PathwayBrowser/#/R-DDI-482772 Release of platelet cytosolic components IEA Dictyostelium discoideum DDB_G0269902 R-DDI-5626507 https://reactome.org/PathwayBrowser/#/R-DDI-5626507 IQGAPs bind F-actin, which is inhibited by calmodulin IEA Dictyostelium discoideum DDB_G0269902 R-DDI-9018787 https://reactome.org/PathwayBrowser/#/R-DDI-9018787 RHOBTB2 binds interacting proteins at the endosome membrane IEA Dictyostelium discoideum DDB_G0269906 R-DDI-109639 https://reactome.org/PathwayBrowser/#/R-DDI-109639 Formation of the closed pre-initiation complex IEA Dictyostelium discoideum DDB_G0269906 R-DDI-111264 https://reactome.org/PathwayBrowser/#/R-DDI-111264 Addition of nucleotides between position +11 and +30 IEA Dictyostelium discoideum DDB_G0269906 R-DDI-112383 https://reactome.org/PathwayBrowser/#/R-DDI-112383 Hypophosphorylation of RNA Pol II CTD by FCP1P protein IEA Dictyostelium discoideum DDB_G0269906 R-DDI-113430 https://reactome.org/PathwayBrowser/#/R-DDI-113430 Extrusion of 5'-end of 30 nt long transcript through the pore in Pol II complex IEA Dictyostelium discoideum DDB_G0269906 R-DDI-5690996 https://reactome.org/PathwayBrowser/#/R-DDI-5690996 ERCC2 and ERCC3 DNA helicases form an open bubble structure in damaged DNA IEA Dictyostelium discoideum DDB_G0269906 R-DDI-5691000 https://reactome.org/PathwayBrowser/#/R-DDI-5691000 TFIIH binds GG-NER site to form a verification complex IEA Dictyostelium discoideum DDB_G0269906 R-DDI-6781818 https://reactome.org/PathwayBrowser/#/R-DDI-6781818 RNA Pol II initiates transcription from damaged DNA template IEA Dictyostelium discoideum DDB_G0269906 R-DDI-6781824 https://reactome.org/PathwayBrowser/#/R-DDI-6781824 Active RNA Pol II complex transcribes lesion-containing DNA template IEA Dictyostelium discoideum DDB_G0269906 R-DDI-6781833 https://reactome.org/PathwayBrowser/#/R-DDI-6781833 ERCC8 (CSA) binds stalled RNA Pol II IEA Dictyostelium discoideum DDB_G0269906 R-DDI-6781840 https://reactome.org/PathwayBrowser/#/R-DDI-6781840 ERCC6 binds stalled RNA Pol II IEA Dictyostelium discoideum DDB_G0269906 R-DDI-6781867 https://reactome.org/PathwayBrowser/#/R-DDI-6781867 ERCC8:DDB1:CUL4:RBX1 ubiquitinates ERCC6 and RNA Pol II IEA Dictyostelium discoideum DDB_G0269906 R-DDI-6782069 https://reactome.org/PathwayBrowser/#/R-DDI-6782069 UVSSA:USP7 deubiquitinates ERCC6 IEA Dictyostelium discoideum DDB_G0269906 R-DDI-6782131 https://reactome.org/PathwayBrowser/#/R-DDI-6782131 ERCC2-facilitated RNA Pol II backtracking in TC-NER IEA Dictyostelium discoideum DDB_G0269906 R-DDI-6782141 https://reactome.org/PathwayBrowser/#/R-DDI-6782141 Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in TC-NER IEA Dictyostelium discoideum DDB_G0269906 R-DDI-6782204 https://reactome.org/PathwayBrowser/#/R-DDI-6782204 5' incision of damaged DNA strand by ERCC1:ERCC4 in TC-NER IEA Dictyostelium discoideum DDB_G0269906 R-DDI-6782208 https://reactome.org/PathwayBrowser/#/R-DDI-6782208 Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in TC-NER IEA Dictyostelium discoideum DDB_G0269906 R-DDI-6782211 https://reactome.org/PathwayBrowser/#/R-DDI-6782211 DNA polymerases delta, epsilon or kappa bind the TC-NER site IEA Dictyostelium discoideum DDB_G0269906 R-DDI-6782227 https://reactome.org/PathwayBrowser/#/R-DDI-6782227 Ligation of newly synthesized repair patch to incised DNA in TC-NER IEA Dictyostelium discoideum DDB_G0269906 R-DDI-6797606 https://reactome.org/PathwayBrowser/#/R-DDI-6797606 CDK12 phosphorylates RNA Pol II CTD at DNA repair genes IEA Dictyostelium discoideum DDB_G0269906 R-DDI-6797616 https://reactome.org/PathwayBrowser/#/R-DDI-6797616 CCNK:CDK12 binds RNA Pol II at DNA repair genes IEA Dictyostelium discoideum DDB_G0269906 R-DDI-73769 https://reactome.org/PathwayBrowser/#/R-DDI-73769 Loss of Rrn3 from RNA Polymerase I promoter escape complex IEA Dictyostelium discoideum DDB_G0269906 R-DDI-73946 https://reactome.org/PathwayBrowser/#/R-DDI-73946 Abortive initiation after formation of the first phosphodiester bond IEA Dictyostelium discoideum DDB_G0269906 R-DDI-74986 https://reactome.org/PathwayBrowser/#/R-DDI-74986 Elongation of pre-rRNA transcript IEA Dictyostelium discoideum DDB_G0269906 R-DDI-75850 https://reactome.org/PathwayBrowser/#/R-DDI-75850 Addition of the third nucleotide on the nascent transcript IEA Dictyostelium discoideum DDB_G0269906 R-DDI-75856 https://reactome.org/PathwayBrowser/#/R-DDI-75856 Abortive Initiation Before Second Transition IEA Dictyostelium discoideum DDB_G0269906 R-DDI-75861 https://reactome.org/PathwayBrowser/#/R-DDI-75861 NTP Binds Active Site of RNA Polymerase II IEA Dictyostelium discoideum DDB_G0269906 R-DDI-75862 https://reactome.org/PathwayBrowser/#/R-DDI-75862 Fall Back to Closed Pre-initiation Complex IEA Dictyostelium discoideum DDB_G0269906 R-DDI-75864 https://reactome.org/PathwayBrowser/#/R-DDI-75864 Newly Formed Phosphodiester Bond Stabilized and PPi Released IEA Dictyostelium discoideum DDB_G0269906 R-DDI-75866 https://reactome.org/PathwayBrowser/#/R-DDI-75866 Nucleophillic Attack by 3'-hydroxyl Oxygen of nascent transcript on the Alpha Phosphate of NTP IEA Dictyostelium discoideum DDB_G0269906 R-DDI-75869 https://reactome.org/PathwayBrowser/#/R-DDI-75869 Addition of the fourth nucleotide on the Nascent Transcript: Second Transition IEA Dictyostelium discoideum DDB_G0269906 R-DDI-75873 https://reactome.org/PathwayBrowser/#/R-DDI-75873 Addition of Nucleotides 5 through 9 on the growing Transcript IEA Dictyostelium discoideum DDB_G0269906 R-DDI-75891 https://reactome.org/PathwayBrowser/#/R-DDI-75891 Abortive Initiation After Second Transition IEA Dictyostelium discoideum DDB_G0269906 R-DDI-75949 https://reactome.org/PathwayBrowser/#/R-DDI-75949 RNA Polymerase II Promoter Opening: First Transition IEA Dictyostelium discoideum DDB_G0269906 R-DDI-76576 https://reactome.org/PathwayBrowser/#/R-DDI-76576 Addition of nucleotides 10 and 11 on the growing transcript: Third Transition IEA Dictyostelium discoideum DDB_G0269906 R-DDI-77068 https://reactome.org/PathwayBrowser/#/R-DDI-77068 Activation of GT IEA Dictyostelium discoideum DDB_G0269906 R-DDI-77069 https://reactome.org/PathwayBrowser/#/R-DDI-77069 RNA Polymerase II CTD (phosphorylated) binds to CE IEA Dictyostelium discoideum DDB_G0269906 R-DDI-77071 https://reactome.org/PathwayBrowser/#/R-DDI-77071 Phosphorylation (Ser5) of RNA pol II CTD IEA Dictyostelium discoideum DDB_G0269906 R-DDI-77073 https://reactome.org/PathwayBrowser/#/R-DDI-77073 SPT5 subunit of Pol II binds the RNA triphosphatase (RTP) IEA Dictyostelium discoideum DDB_G0269906 R-DDI-77077 https://reactome.org/PathwayBrowser/#/R-DDI-77077 Capping complex formation IEA Dictyostelium discoideum DDB_G0269906 R-DDI-77078 https://reactome.org/PathwayBrowser/#/R-DDI-77078 Hydrolysis of the 5'-end of the nascent transcript by the capping enzyme IEA Dictyostelium discoideum DDB_G0269906 R-DDI-77081 https://reactome.org/PathwayBrowser/#/R-DDI-77081 Formation of the CE:GMP intermediate complex IEA Dictyostelium discoideum DDB_G0269906 R-DDI-77083 https://reactome.org/PathwayBrowser/#/R-DDI-77083 Transfer of GMP from the capping enzyme GT site to 5'-end of mRNA IEA Dictyostelium discoideum DDB_G0269906 R-DDI-77085 https://reactome.org/PathwayBrowser/#/R-DDI-77085 Dissociation of transcript with 5'-GMP from GT IEA Dictyostelium discoideum DDB_G0269906 R-DDI-77090 https://reactome.org/PathwayBrowser/#/R-DDI-77090 Methylation of GMP-cap by RNA Methyltransferase IEA Dictyostelium discoideum DDB_G0269906 R-DDI-9613494 https://reactome.org/PathwayBrowser/#/R-DDI-9613494 Unwinding of DNA for the Nascent Transcript: Second Transition IEA Dictyostelium discoideum DDB_G0269906 R-DDI-9613497 https://reactome.org/PathwayBrowser/#/R-DDI-9613497 Unwinding DNA for the nascent transcript IEA Dictyostelium discoideum DDB_G0269906 R-DDI-9684118 https://reactome.org/PathwayBrowser/#/R-DDI-9684118 ERCC3-facilitated RNA Pol II backtracking in TC-NER IEA Dictyostelium discoideum DDB_G0269908 R-DDI-5693761 https://reactome.org/PathwayBrowser/#/R-DDI-5693761 FA2H hydroxylates 1,2-saturated fatty acids IEA Dictyostelium discoideum DDB_G0269912 R-DDI-1497784 https://reactome.org/PathwayBrowser/#/R-DDI-1497784 The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle IEA Dictyostelium discoideum DDB_G0269912 R-DDI-1497796 https://reactome.org/PathwayBrowser/#/R-DDI-1497796 BH2 binding can lead to eNOS uncoupling IEA Dictyostelium discoideum DDB_G0269912 R-DDI-1497810 https://reactome.org/PathwayBrowser/#/R-DDI-1497810 Uncoupled eNOS favours the formation of superoxide IEA Dictyostelium discoideum DDB_G0269912 R-DDI-202111 https://reactome.org/PathwayBrowser/#/R-DDI-202111 AKT1 phosphorylates eNOS IEA Dictyostelium discoideum DDB_G0269912 R-DDI-202127 https://reactome.org/PathwayBrowser/#/R-DDI-202127 eNOS synthesizes NO IEA Dictyostelium discoideum DDB_G0269912 R-DDI-202132 https://reactome.org/PathwayBrowser/#/R-DDI-202132 depalmitoylated eNOS translocates from plasma membrane IEA Dictyostelium discoideum DDB_G0269912 R-DDI-202137 https://reactome.org/PathwayBrowser/#/R-DDI-202137 AKT1 binds eNOS complex via HSP90 IEA Dictyostelium discoideum DDB_G0269912 R-DDI-203553 https://reactome.org/PathwayBrowser/#/R-DDI-203553 eNOS binds NOSIP IEA Dictyostelium discoideum DDB_G0269912 R-DDI-203567 https://reactome.org/PathwayBrowser/#/R-DDI-203567 Palmitoylation of eNOS IEA Dictyostelium discoideum DDB_G0269912 R-DDI-203613 https://reactome.org/PathwayBrowser/#/R-DDI-203613 Depalmitoylation of eNOS IEA Dictyostelium discoideum DDB_G0269912 R-DDI-203680 https://reactome.org/PathwayBrowser/#/R-DDI-203680 eNOS:NOSIP translocation from caveolae to intracellular compartments IEA Dictyostelium discoideum DDB_G0269912 R-DDI-203700 https://reactome.org/PathwayBrowser/#/R-DDI-203700 eNOS translocation from Golgi to Caveolae IEA Dictyostelium discoideum DDB_G0269912 R-DDI-418436 https://reactome.org/PathwayBrowser/#/R-DDI-418436 Nitric Oxide Synthase (NOS) produces Nitric Oxide (NO) IEA Dictyostelium discoideum DDB_G0269912 R-DDI-5617178 https://reactome.org/PathwayBrowser/#/R-DDI-5617178 ATP2B4 binds to NOS1, inhibiting it IEA Dictyostelium discoideum DDB_G0269912 R-DDI-9033235 https://reactome.org/PathwayBrowser/#/R-DDI-9033235 Cargo of PEX5S,L translocates from the cytosol to the peroxisomal matrix IEA Dictyostelium discoideum DDB_G0269912 R-DDI-9033236 https://reactome.org/PathwayBrowser/#/R-DDI-9033236 PEX5S,L:Cargo binds PEX13:PEX14:PEX2:PEX10:PEX12 (Docking and Translocation Module) IEA Dictyostelium discoideum DDB_G0269912 R-DDI-9860792 https://reactome.org/PathwayBrowser/#/R-DDI-9860792 Phospho-AKT1 phosphorylates NOS3 (eNOS) on serine-1177 IEA Dictyostelium discoideum DDB_G0269912 R-DDI-9860808 https://reactome.org/PathwayBrowser/#/R-DDI-9860808 p-T816-PKN2 phosphorylates NOS3 (eNOS) on serine-1179 IEA Dictyostelium discoideum DDB_G0269916 R-DDI-8986181 https://reactome.org/PathwayBrowser/#/R-DDI-8986181 PITRM1 proteolyzes mitochondrial targeting peptides (presequences) IEA Dictyostelium discoideum DDB_G0269916 R-DDI-9838081 https://reactome.org/PathwayBrowser/#/R-DDI-9838081 LONP1 degrades mitochondrial matrix proteins IEA Dictyostelium discoideum DDB_G0269916 R-DDI-9838093 https://reactome.org/PathwayBrowser/#/R-DDI-9838093 LONP1 binds mitochondrial matrix proteins IEA Dictyostelium discoideum DDB_G0269918 R-DDI-203797 https://reactome.org/PathwayBrowser/#/R-DDI-203797 ERKs are inactivated by dual-specific phosphatases (DUSPs) IEA Dictyostelium discoideum DDB_G0269918 R-DDI-5675373 https://reactome.org/PathwayBrowser/#/R-DDI-5675373 Nuclear DUSPs dephosphorylate MAPKs IEA Dictyostelium discoideum DDB_G0269918 R-DDI-5675376 https://reactome.org/PathwayBrowser/#/R-DDI-5675376 Cytosolic DUSPs dephosphorylate MAPKs IEA Dictyostelium discoideum DDB_G0269922 R-DDI-450431 https://reactome.org/PathwayBrowser/#/R-DDI-450431 ZFP36 (TTP) recruits RNA degradation activities IEA Dictyostelium discoideum DDB_G0269922 R-DDI-450488 https://reactome.org/PathwayBrowser/#/R-DDI-450488 BRF1 Complex recruits RNA degradation activities IEA Dictyostelium discoideum DDB_G0269922 R-DDI-6791227 https://reactome.org/PathwayBrowser/#/R-DDI-6791227 47S pre-rRNA is nucleolytically processed at A' (01,A1), site A0, and site 02 (site 6) to yield 45S pre-rRNA IEA Dictyostelium discoideum DDB_G0269932 R-DDI-9018787 https://reactome.org/PathwayBrowser/#/R-DDI-9018787 RHOBTB2 binds interacting proteins at the endosome membrane IEA Dictyostelium discoideum DDB_G0269932 R-DDI-9770236 https://reactome.org/PathwayBrowser/#/R-DDI-9770236 Formation of the Spliceosomal P complex and exon ligation IEA Dictyostelium discoideum DDB_G0269938 R-DDI-8867876 https://reactome.org/PathwayBrowser/#/R-DDI-8867876 OSBPL5,8,10 exchange PS with PI4P from ER membrane to plasma membrane IEA Dictyostelium discoideum DDB_G0269938 R-DDI-9018758 https://reactome.org/PathwayBrowser/#/R-DDI-9018758 RHOH binds effectors at the plasma membrane IEA Dictyostelium discoideum DDB_G0269940 R-DDI-8867876 https://reactome.org/PathwayBrowser/#/R-DDI-8867876 OSBPL5,8,10 exchange PS with PI4P from ER membrane to plasma membrane IEA Dictyostelium discoideum DDB_G0269940 R-DDI-9018758 https://reactome.org/PathwayBrowser/#/R-DDI-9018758 RHOH binds effectors at the plasma membrane IEA Dictyostelium discoideum DDB_G0269942 R-DDI-204008 https://reactome.org/PathwayBrowser/#/R-DDI-204008 SEC31:SEC13 and v-SNARE recruitment IEA Dictyostelium discoideum DDB_G0269942 R-DDI-5694409 https://reactome.org/PathwayBrowser/#/R-DDI-5694409 Nucleotide exchange on RAB1 IEA Dictyostelium discoideum DDB_G0269942 R-DDI-5694415 https://reactome.org/PathwayBrowser/#/R-DDI-5694415 SEC24A,B:SEC23A bind SEC22B IEA Dictyostelium discoideum DDB_G0269942 R-DDI-5694423 https://reactome.org/PathwayBrowser/#/R-DDI-5694423 NSF and SNAPs bind cis-SNARE complex IEA Dictyostelium discoideum DDB_G0269942 R-DDI-5694425 https://reactome.org/PathwayBrowser/#/R-DDI-5694425 NSF ATPase activity dissociates cis-SNARE IEA Dictyostelium discoideum DDB_G0269942 R-DDI-5694439 https://reactome.org/PathwayBrowser/#/R-DDI-5694439 COPII coat binds TRAPPCII and RAB1:GDP IEA Dictyostelium discoideum DDB_G0269942 R-DDI-5694441 https://reactome.org/PathwayBrowser/#/R-DDI-5694441 CSNK1D phosphorylates SEC23 IEA Dictyostelium discoideum DDB_G0269942 R-DDI-6811417 https://reactome.org/PathwayBrowser/#/R-DDI-6811417 ARFGAP, cargo, vSNARES and p24 proteins bind COPI vesicles at Golgi IEA Dictyostelium discoideum DDB_G0269942 R-DDI-6811418 https://reactome.org/PathwayBrowser/#/R-DDI-6811418 ARFGAPs stimulate ARF GTPase activity at the Golgi membrane IEA Dictyostelium discoideum DDB_G0269942 R-DDI-6811422 https://reactome.org/PathwayBrowser/#/R-DDI-6811422 NSF ATPase activity dissociates cis-SNARE at the ER IEA Dictyostelium discoideum DDB_G0269942 R-DDI-6811425 https://reactome.org/PathwayBrowser/#/R-DDI-6811425 NSF and SNAPs bind cis-SNARE at the ER membrane IEA Dictyostelium discoideum DDB_G0269942 R-DDI-6811427 https://reactome.org/PathwayBrowser/#/R-DDI-6811427 COPI vesicle uncoating at the ER IEA Dictyostelium discoideum DDB_G0269948 R-DDI-450400 https://reactome.org/PathwayBrowser/#/R-DDI-450400 ZFP36 (Tristetraproline, TTP) binds AU-rich elements in 3' UTR of target mRNAs IEA Dictyostelium discoideum DDB_G0269948 R-DDI-450431 https://reactome.org/PathwayBrowser/#/R-DDI-450431 ZFP36 (TTP) recruits RNA degradation activities IEA Dictyostelium discoideum DDB_G0269950 R-DDI-977333 https://reactome.org/PathwayBrowser/#/R-DDI-977333 PXLP-K200-PSAT1 dimer transfers amino group from L-Glu to 3POPA IEA Dictyostelium discoideum DDB_G0270000 R-DDI-983140 https://reactome.org/PathwayBrowser/#/R-DDI-983140 Transfer of Ub from E2 to substrate and release of E2 IEA Dictyostelium discoideum DDB_G0270000 R-DDI-983147 https://reactome.org/PathwayBrowser/#/R-DDI-983147 Release of E3 from polyubiquitinated substrate IEA Dictyostelium discoideum DDB_G0270000 R-DDI-983156 https://reactome.org/PathwayBrowser/#/R-DDI-983156 Polyubiquitination of substrate IEA Dictyostelium discoideum DDB_G0270000 R-DDI-983157 https://reactome.org/PathwayBrowser/#/R-DDI-983157 Interaction of E3 with substrate and E2-Ub complex IEA Dictyostelium discoideum DDB_G0270040 R-DDI-6811427 https://reactome.org/PathwayBrowser/#/R-DDI-6811427 COPI vesicle uncoating at the ER IEA Dictyostelium discoideum DDB_G0270042 R-DDI-9770236 https://reactome.org/PathwayBrowser/#/R-DDI-9770236 Formation of the Spliceosomal P complex and exon ligation IEA Dictyostelium discoideum DDB_G0270046 R-DDI-1112538 https://reactome.org/PathwayBrowser/#/R-DDI-1112538 Phosphorylated STAT1, STAT3 form dimers IEA Dictyostelium discoideum DDB_G0270046 R-DDI-1112587 https://reactome.org/PathwayBrowser/#/R-DDI-1112587 STAT1 and STAT3 dimers translocate to the nucleus IEA Dictyostelium discoideum DDB_G0270046 R-DDI-1169406 https://reactome.org/PathwayBrowser/#/R-DDI-1169406 ISGylation of host proteins IEA Dictyostelium discoideum DDB_G0270046 R-DDI-3249370 https://reactome.org/PathwayBrowser/#/R-DDI-3249370 p-S407,Y641-STAT6 dimer migrates to the nucleus IEA Dictyostelium discoideum DDB_G0270046 R-DDI-3249372 https://reactome.org/PathwayBrowser/#/R-DDI-3249372 p-S407,Y641-STAT6 is dimerized IEA Dictyostelium discoideum DDB_G0270046 R-DDI-3249379 https://reactome.org/PathwayBrowser/#/R-DDI-3249379 p-S407-STAT6 is phosphorylated at Tyr641 IEA Dictyostelium discoideum DDB_G0270046 R-DDI-6784763 https://reactome.org/PathwayBrowser/#/R-DDI-6784763 p-Y705-STAT3 dimer translocates from cytosol to nucleoplasm IEA Dictyostelium discoideum DDB_G0270046 R-DDI-6784765 https://reactome.org/PathwayBrowser/#/R-DDI-6784765 p-Y705-STAT3 dimerizes IEA Dictyostelium discoideum DDB_G0270046 R-DDI-6786097 https://reactome.org/PathwayBrowser/#/R-DDI-6786097 p-Y705-STAT3, p-Y641-STAT6 dimerise IEA Dictyostelium discoideum DDB_G0270046 R-DDI-6786293 https://reactome.org/PathwayBrowser/#/R-DDI-6786293 p-Y705-STAT3 dimer, p-Y641-STAT6 dimer translocate to nucleus IEA Dictyostelium discoideum DDB_G0270046 R-DDI-6788622 https://reactome.org/PathwayBrowser/#/R-DDI-6788622 p-Y-STATs dimerize IEA Dictyostelium discoideum DDB_G0270046 R-DDI-6788623 https://reactome.org/PathwayBrowser/#/R-DDI-6788623 p-Y-STATs translocate to nucleus IEA Dictyostelium discoideum DDB_G0270046 R-DDI-6790038 https://reactome.org/PathwayBrowser/#/R-DDI-6790038 Expression of HSP90B1 IEA Dictyostelium discoideum DDB_G0270046 R-DDI-873917 https://reactome.org/PathwayBrowser/#/R-DDI-873917 Translocation of STAT1 dimer to nucleus IEA Dictyostelium discoideum DDB_G0270046 R-DDI-8950181 https://reactome.org/PathwayBrowser/#/R-DDI-8950181 Y693-STAT4 dimer translocates to the nucleus IEA Dictyostelium discoideum DDB_G0270046 R-DDI-8950522 https://reactome.org/PathwayBrowser/#/R-DDI-8950522 p-STAT1:p-STAT4 translocates to the nucleus IEA Dictyostelium discoideum DDB_G0270046 R-DDI-8950724 https://reactome.org/PathwayBrowser/#/R-DDI-8950724 p-Y705-STAT3:p-Y693-STAT4 translocates to the nucleus IEA Dictyostelium discoideum DDB_G0270046 R-DDI-8950733 https://reactome.org/PathwayBrowser/#/R-DDI-8950733 p-Y701-STAT1:p-Y705-STAT3 translocates to the nucleus IEA Dictyostelium discoideum DDB_G0270046 R-DDI-8950778 https://reactome.org/PathwayBrowser/#/R-DDI-8950778 p-Y693-STAT4 dimerizes IEA Dictyostelium discoideum DDB_G0270046 R-DDI-8950780 https://reactome.org/PathwayBrowser/#/R-DDI-8950780 p-Y705-STAT3 binds p-Y693-STAT4 IEA Dictyostelium discoideum DDB_G0270046 R-DDI-8950782 https://reactome.org/PathwayBrowser/#/R-DDI-8950782 p-STAT1 binds p-STAT3 IEA Dictyostelium discoideum DDB_G0270046 R-DDI-8983373 https://reactome.org/PathwayBrowser/#/R-DDI-8983373 p-Y-STAT3 binds p-STAT5 IEA Dictyostelium discoideum DDB_G0270046 R-DDI-8983379 https://reactome.org/PathwayBrowser/#/R-DDI-8983379 p-Y-STAT3:p-STAT5 translocates to the nucleus IEA Dictyostelium discoideum DDB_G0270046 R-DDI-8985943 https://reactome.org/PathwayBrowser/#/R-DDI-8985943 p-Y701-STAT1 dimerizes IEA Dictyostelium discoideum DDB_G0270046 R-DDI-8985950 https://reactome.org/PathwayBrowser/#/R-DDI-8985950 p-Y694-STAT5A, p-STAT5B dimerizes IEA Dictyostelium discoideum DDB_G0270046 R-DDI-8985966 https://reactome.org/PathwayBrowser/#/R-DDI-8985966 p-Y701-STAT1 binds p-Y705-STAT3 IEA Dictyostelium discoideum DDB_G0270046 R-DDI-8985981 https://reactome.org/PathwayBrowser/#/R-DDI-8985981 p-Y701-STAT1:p-Y705-STAT3 translocates from the cytosol to the nucleus IEA Dictyostelium discoideum DDB_G0270046 R-DDI-8985983 https://reactome.org/PathwayBrowser/#/R-DDI-8985983 p-Y701-STAT1 dimer translocates from the cytosol to the nucleus IEA Dictyostelium discoideum DDB_G0270046 R-DDI-8987007 https://reactome.org/PathwayBrowser/#/R-DDI-8987007 p-STAT1 dimerizes IEA Dictyostelium discoideum DDB_G0270046 R-DDI-8987052 https://reactome.org/PathwayBrowser/#/R-DDI-8987052 p-STAT3 dimer translocates from cytosol to nucleoplasm IEA Dictyostelium discoideum DDB_G0270046 R-DDI-8987214 https://reactome.org/PathwayBrowser/#/R-DDI-8987214 p-STAT3 dimerizes IEA Dictyostelium discoideum DDB_G0270046 R-DDI-8987218 https://reactome.org/PathwayBrowser/#/R-DDI-8987218 p-STAT1 dimer translocates from the cytosol to the nucleoplasm IEA Dictyostelium discoideum DDB_G0270046 R-DDI-9009072 https://reactome.org/PathwayBrowser/#/R-DDI-9009072 STAT3 phosphorylation IEA Dictyostelium discoideum DDB_G0270046 R-DDI-9701525 https://reactome.org/PathwayBrowser/#/R-DDI-9701525 p-Y705,S727-STAT3 dimerizes IEA Dictyostelium discoideum DDB_G0270046 R-DDI-9701529 https://reactome.org/PathwayBrowser/#/R-DDI-9701529 p-Y705, p-S727 STAT3 dimer translocates to the nucleus IEA Dictyostelium discoideum DDB_G0270046 R-DDI-9701565 https://reactome.org/PathwayBrowser/#/R-DDI-9701565 HDACs deacetylate p-STAT3 dimers IEA Dictyostelium discoideum DDB_G0270046 R-DDI-9710959 https://reactome.org/PathwayBrowser/#/R-DDI-9710959 p-STAT1 dimer binds KPNA1 IEA Dictyostelium discoideum DDB_G0270046 R-DDI-9865511 https://reactome.org/PathwayBrowser/#/R-DDI-9865511 Phosphorylation of STAT1 on tyrosine-701 is enhanced by p-S172-IKBKE IEA Dictyostelium discoideum DDB_G0270098 R-DDI-5205649 https://reactome.org/PathwayBrowser/#/R-DDI-5205649 p62 links damaged mitochondria to LC3 IEA Dictyostelium discoideum DDB_G0270098 R-DDI-5205663 https://reactome.org/PathwayBrowser/#/R-DDI-5205663 LC3 binds the autophagosome membrane Atg5-Atg12 complex IEA Dictyostelium discoideum DDB_G0270098 R-DDI-5205673 https://reactome.org/PathwayBrowser/#/R-DDI-5205673 p62 binds ubiquitinated mitochondrial substrates IEA Dictyostelium discoideum DDB_G0270098 R-DDI-9664855 https://reactome.org/PathwayBrowser/#/R-DDI-9664855 MAP1LC3B binds ATM dimer:Ub-p-PEX5:SQSTM1 IEA Dictyostelium discoideum DDB_G0270098 R-DDI-9664880 https://reactome.org/PathwayBrowser/#/R-DDI-9664880 MAP1LC3B binds ATM dimer:Ub-p-PEX5:SQSTM1:NBR1 IEA Dictyostelium discoideum DDB_G0270098 R-DDI-9664881 https://reactome.org/PathwayBrowser/#/R-DDI-9664881 NBR1 binds ATM:Ub-p-PEX5:SQSTM1 IEA Dictyostelium discoideum DDB_G0270098 R-DDI-9664892 https://reactome.org/PathwayBrowser/#/R-DDI-9664892 SQSTM1 binds ATM dimer:Ub-p-PEX5 IEA Dictyostelium discoideum DDB_G0270098 R-DDI-9759158 https://reactome.org/PathwayBrowser/#/R-DDI-9759158 SQSTM1 oligomerizes IEA Dictyostelium discoideum DDB_G0270098 R-DDI-9759169 https://reactome.org/PathwayBrowser/#/R-DDI-9759169 p-S349 SQSTM1 oligomer binds KEAP1:CUL3:RBX1 IEA Dictyostelium discoideum DDB_G0270098 R-DDI-9759172 https://reactome.org/PathwayBrowser/#/R-DDI-9759172 KEAP1:CUL3:RBX1 ubiquitinates p-S349 SQSTM1 oligomer IEA Dictyostelium discoideum DDB_G0270098 R-DDI-9766645 https://reactome.org/PathwayBrowser/#/R-DDI-9766645 CUL3:RBX1 ubiquitinates KEAP1 IEA Dictyostelium discoideum DDB_G0270098 R-DDI-9766656 https://reactome.org/PathwayBrowser/#/R-DDI-9766656 RBX1:CUL3 dissociates from forming autophagosome IEA Dictyostelium discoideum DDB_G0270098 R-DDI-9766677 https://reactome.org/PathwayBrowser/#/R-DDI-9766677 MAP1LC3B binds KEAP1 and SQSTM1 IEA Dictyostelium discoideum DDB_G0270098 R-DDI-9766687 https://reactome.org/PathwayBrowser/#/R-DDI-9766687 SESN1,SESN1 bind SQSTM1 and KEAP1 IEA Dictyostelium discoideum DDB_G0270102 R-DDI-376419 https://reactome.org/PathwayBrowser/#/R-DDI-376419 Formation of NR-MED1 Coactivator Complex IEA Dictyostelium discoideum DDB_G0270106 R-DDI-5695957 https://reactome.org/PathwayBrowser/#/R-DDI-5695957 ACSBG1,2 ligates CoA-SH to VLCFA, forming VLCFA-CoA IEA Dictyostelium discoideum DDB_G0270120 R-DDI-70994 https://reactome.org/PathwayBrowser/#/R-DDI-70994 SDH complex dehydrogenates succinate IEA Dictyostelium discoideum DDB_G0270128 R-DDI-9018778 https://reactome.org/PathwayBrowser/#/R-DDI-9018778 RHOBTB1 binds interacting proteins at the endosome membrane IEA Dictyostelium discoideum DDB_G0270128 R-DDI-9018787 https://reactome.org/PathwayBrowser/#/R-DDI-9018787 RHOBTB2 binds interacting proteins at the endosome membrane IEA Dictyostelium discoideum DDB_G0270128 R-DDI-9770236 https://reactome.org/PathwayBrowser/#/R-DDI-9770236 Formation of the Spliceosomal P complex and exon ligation IEA Dictyostelium discoideum DDB_G0270134 R-DDI-6798748 https://reactome.org/PathwayBrowser/#/R-DDI-6798748 Exocytosis of secretory granule lumen proteins IEA Dictyostelium discoideum DDB_G0270134 R-DDI-6800434 https://reactome.org/PathwayBrowser/#/R-DDI-6800434 Exocytosis of ficolin-rich granule lumen proteins IEA Dictyostelium discoideum DDB_G0270146 R-DDI-2730868 https://reactome.org/PathwayBrowser/#/R-DDI-2730868 Phosphorylation of MEK7 by MEKK1 IEA Dictyostelium discoideum DDB_G0270146 R-DDI-2730896 https://reactome.org/PathwayBrowser/#/R-DDI-2730896 Phosphorylation of MEK4 by MEKK1 IEA Dictyostelium discoideum DDB_G0270148 R-DDI-77589 https://reactome.org/PathwayBrowser/#/R-DDI-77589 Recognition of AAUAAA sequence by CPSF IEA Dictyostelium discoideum DDB_G0270148 R-DDI-77590 https://reactome.org/PathwayBrowser/#/R-DDI-77590 Recruitment of CstF to the CPSF Bound Pre-mRNA IEA Dictyostelium discoideum DDB_G0270150 R-DDI-6811427 https://reactome.org/PathwayBrowser/#/R-DDI-6811427 COPI vesicle uncoating at the ER IEA Dictyostelium discoideum DDB_G0270184 R-DDI-6787623 https://reactome.org/PathwayBrowser/#/R-DDI-6787623 TSTA3 dimer epimerises GDP-DHDMan to GDP-KDGal IEA Dictyostelium discoideum DDB_G0270184 R-DDI-6787642 https://reactome.org/PathwayBrowser/#/R-DDI-6787642 TSTA3 dimer reduces GDP-KDGal to GDP-Fuc IEA Dictyostelium discoideum DDB_G0270188 R-DDI-1236970 https://reactome.org/PathwayBrowser/#/R-DDI-1236970 Proteasomal clevage of exogenous antigen (26S proteasome catalyst) IEA Dictyostelium discoideum DDB_G0270188 R-DDI-1504193 https://reactome.org/PathwayBrowser/#/R-DDI-1504193 Ubiquitinated DVL is degraded by the proteasome IEA Dictyostelium discoideum DDB_G0270188 R-DDI-174058 https://reactome.org/PathwayBrowser/#/R-DDI-174058 Degradation of multiubiquitinated Cdh1 IEA Dictyostelium discoideum DDB_G0270188 R-DDI-174105 https://reactome.org/PathwayBrowser/#/R-DDI-174105 Degradation of multiubiquitinated cell cycle proteins IEA Dictyostelium discoideum DDB_G0270188 R-DDI-174202 https://reactome.org/PathwayBrowser/#/R-DDI-174202 Degradation of multiubiquitinated Securin IEA Dictyostelium discoideum DDB_G0270188 R-DDI-188191 https://reactome.org/PathwayBrowser/#/R-DDI-188191 APC/C:Cdh1-mediated degradation of Skp2 IEA Dictyostelium discoideum DDB_G0270188 R-DDI-264458 https://reactome.org/PathwayBrowser/#/R-DDI-264458 Proteasome mediated degradation of COP1 IEA Dictyostelium discoideum DDB_G0270188 R-DDI-450466 https://reactome.org/PathwayBrowser/#/R-DDI-450466 AUF1:mRNA complex is destroyed IEA Dictyostelium discoideum DDB_G0270188 R-DDI-5635854 https://reactome.org/PathwayBrowser/#/R-DDI-5635854 GLI2,3 are degraded by the proteasome IEA Dictyostelium discoideum DDB_G0270188 R-DDI-5658430 https://reactome.org/PathwayBrowser/#/R-DDI-5658430 NF1 is degraded by the proteasome IEA Dictyostelium discoideum DDB_G0270188 R-DDI-5665854 https://reactome.org/PathwayBrowser/#/R-DDI-5665854 ADRM1:26S proteaseome binds UCHL5 IEA Dictyostelium discoideum DDB_G0270188 R-DDI-5665871 https://reactome.org/PathwayBrowser/#/R-DDI-5665871 ADRM1 binds 26S proteasome IEA Dictyostelium discoideum DDB_G0270188 R-DDI-5687112 https://reactome.org/PathwayBrowser/#/R-DDI-5687112 MAPK6 is degraded by the 26S proteasome IEA Dictyostelium discoideum DDB_G0270188 R-DDI-5689539 https://reactome.org/PathwayBrowser/#/R-DDI-5689539 ADRM1:26S proteaseome binds USP14 IEA Dictyostelium discoideum DDB_G0270188 R-DDI-6798748 https://reactome.org/PathwayBrowser/#/R-DDI-6798748 Exocytosis of secretory granule lumen proteins IEA Dictyostelium discoideum DDB_G0270188 R-DDI-6800434 https://reactome.org/PathwayBrowser/#/R-DDI-6800434 Exocytosis of ficolin-rich granule lumen proteins IEA Dictyostelium discoideum DDB_G0270188 R-DDI-68948 https://reactome.org/PathwayBrowser/#/R-DDI-68948 Ubiquitinated Orc1 is degraded by the proteasome IEA Dictyostelium discoideum DDB_G0270188 R-DDI-69016 https://reactome.org/PathwayBrowser/#/R-DDI-69016 Ubiquitinated Cdc6 is degraded by the proteasome IEA Dictyostelium discoideum DDB_G0270188 R-DDI-69600 https://reactome.org/PathwayBrowser/#/R-DDI-69600 Proteolytic degradation of ubiquitinated-Cdc25A IEA Dictyostelium discoideum DDB_G0270188 R-DDI-8850992 https://reactome.org/PathwayBrowser/#/R-DDI-8850992 Proteasome degrades polyubiquitinated PTEN IEA Dictyostelium discoideum DDB_G0270188 R-DDI-8854044 https://reactome.org/PathwayBrowser/#/R-DDI-8854044 Proteasome degrades AURKA ubiquitinated by SCF-FBXL7 IEA Dictyostelium discoideum DDB_G0270188 R-DDI-8866553 https://reactome.org/PathwayBrowser/#/R-DDI-8866553 misfolded CFTR is degraded by the 26S proteasome IEA Dictyostelium discoideum DDB_G0270188 R-DDI-9755306 https://reactome.org/PathwayBrowser/#/R-DDI-9755306 ub UBXN7 is degraded by the 26S proteasome IEA Dictyostelium discoideum DDB_G0270188 R-DDI-983150 https://reactome.org/PathwayBrowser/#/R-DDI-983150 Proteasomal cleavage of substrate IEA Dictyostelium discoideum DDB_G0270188 R-DDI-9908019 https://reactome.org/PathwayBrowser/#/R-DDI-9908019 Formation of the 19S regulatory particle lid IEA Dictyostelium discoideum DDB_G0270188 R-DDI-9908026 https://reactome.org/PathwayBrowser/#/R-DDI-9908026 Formation of the 19S regulatory particle precursor IEA Dictyostelium discoideum DDB_G0270188 R-DDI-9908178 https://reactome.org/PathwayBrowser/#/R-DDI-9908178 Formation of the 26S proteasome IEA Dictyostelium discoideum DDB_G0270198 R-DDI-74986 https://reactome.org/PathwayBrowser/#/R-DDI-74986 Elongation of pre-rRNA transcript IEA Dictyostelium discoideum DDB_G0270198 R-DDI-9843978 https://reactome.org/PathwayBrowser/#/R-DDI-9843978 CBX5 (HP-1alpha) binds TRIM28 (KAP1) in SUMO2-6K-TRIM28:KRAB-ZFP:retroelement chromatin IEA Dictyostelium discoideum DDB_G0270198 R-DDI-994106 https://reactome.org/PathwayBrowser/#/R-DDI-994106 HP1 alpha binds Histone H3K9(me)3 IEA Dictyostelium discoideum DDB_G0270200 R-DDI-5674019 https://reactome.org/PathwayBrowser/#/R-DDI-5674019 BRAP binds KSR1:MARK3 IEA Dictyostelium discoideum DDB_G0270206 R-DDI-9609921 https://reactome.org/PathwayBrowser/#/R-DDI-9609921 SGTA binds Tail-anchored protein IEA Dictyostelium discoideum DDB_G0270206 R-DDI-9617595 https://reactome.org/PathwayBrowser/#/R-DDI-9617595 SGTA binds mislocalized membrane protein IEA Dictyostelium discoideum DDB_G0270208 R-DDI-3215385 https://reactome.org/PathwayBrowser/#/R-DDI-3215385 CDK4 in CCND1:CDK4:PRMT5:WDR77 phosphorylates WDR77 IEA Dictyostelium discoideum DDB_G0270208 R-DDI-3215406 https://reactome.org/PathwayBrowser/#/R-DDI-3215406 PRMT5 binds WDR77 IEA Dictyostelium discoideum DDB_G0270208 R-DDI-3215448 https://reactome.org/PathwayBrowser/#/R-DDI-3215448 SWI/SNF chromatin remodelling complex enhances MEP50:PRMT5 methyltransferase activity IEA Dictyostelium discoideum DDB_G0270208 R-DDI-5205799 https://reactome.org/PathwayBrowser/#/R-DDI-5205799 CCND1:CDK4:PRMT5:pT5-WDR77 methylates arginine-9 of histone H3 (H3R8) IEA Dictyostelium discoideum DDB_G0270208 R-DDI-5218952 https://reactome.org/PathwayBrowser/#/R-DDI-5218952 PRMT5:WDR77, PRMT7 methylate arginine-3 of histone H3 (H3R2) IEA Dictyostelium discoideum DDB_G0270208 R-DDI-5661117 https://reactome.org/PathwayBrowser/#/R-DDI-5661117 CCND1:CDK4:PRMT5:pT5-WDR77 methylates methyl-arginine-9 of histone H3 IEA Dictyostelium discoideum DDB_G0270208 R-DDI-9605682 https://reactome.org/PathwayBrowser/#/R-DDI-9605682 FUT3,5,6,7 transfers Fuc to Type 2 MSGG to form sLeX IEA Dictyostelium discoideum DDB_G0270210 R-DDI-2586748 https://reactome.org/PathwayBrowser/#/R-DDI-2586748 GUCA binds Ca2+ to form GUCA:Ca2+ IEA Dictyostelium discoideum DDB_G0270210 R-DDI-74885 https://reactome.org/PathwayBrowser/#/R-DDI-74885 GUCYs converts GTP to cGMP IEA Dictyostelium discoideum DDB_G0270220 R-DDI-6807875 https://reactome.org/PathwayBrowser/#/R-DDI-6807875 ARFGAP, cargo, v-SNAREs and p24 proteins bind nascent COPI complex IEA Dictyostelium discoideum DDB_G0270220 R-DDI-6807877 https://reactome.org/PathwayBrowser/#/R-DDI-6807877 ARFGAPs stimulate ARF GTPase activity IEA Dictyostelium discoideum DDB_G0270220 R-DDI-6809003 https://reactome.org/PathwayBrowser/#/R-DDI-6809003 ERGIC-to-Golgi vesicles bind dynein:dynactin IEA Dictyostelium discoideum DDB_G0270220 R-DDI-6809011 https://reactome.org/PathwayBrowser/#/R-DDI-6809011 cis-Golgi t-SNAREs bind YKT6 on tethered vesicle IEA Dictyostelium discoideum DDB_G0270220 R-DDI-8952039 https://reactome.org/PathwayBrowser/#/R-DDI-8952039 NEDD8:AcM-UBE2F binds CRL5 E3 ubiquitin ligase complex IEA Dictyostelium discoideum DDB_G0270220 R-DDI-8952044 https://reactome.org/PathwayBrowser/#/R-DDI-8952044 AcM-UBE2F transfers NEDD8 to CRL5 E3 ubiquitin ligase complex IEA Dictyostelium discoideum DDB_G0270220 R-DDI-8955241 https://reactome.org/PathwayBrowser/#/R-DDI-8955241 CAND1 binds cytosolic CRL E3 ubiquitin ligases IEA Dictyostelium discoideum DDB_G0270220 R-DDI-8955289 https://reactome.org/PathwayBrowser/#/R-DDI-8955289 COMMDs displace CAND1 from cytosolic CRL E3 ubiquitin ligase complexes IEA Dictyostelium discoideum DDB_G0270220 R-DDI-8956040 https://reactome.org/PathwayBrowser/#/R-DDI-8956040 COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes IEA Dictyostelium discoideum DDB_G0270230 R-DDI-6791222 https://reactome.org/PathwayBrowser/#/R-DDI-6791222 21S pre-rRNA is nucleolytically processed at site E (site2a) to yield 18SE pre-rRNA IEA Dictyostelium discoideum DDB_G0270230 R-DDI-6791227 https://reactome.org/PathwayBrowser/#/R-DDI-6791227 47S pre-rRNA is nucleolytically processed at A' (01,A1), site A0, and site 02 (site 6) to yield 45S pre-rRNA IEA Dictyostelium discoideum DDB_G0270246 R-DDI-9624845 https://reactome.org/PathwayBrowser/#/R-DDI-9624845 RCC1 stimulates GDP to GTP exchange on RAN IEA Dictyostelium discoideum DDB_G0270252 R-DDI-381135 https://reactome.org/PathwayBrowser/#/R-DDI-381135 MBTPS1 (S1P) cleaves ATF6 (ATF6-alpha) IEA Dictyostelium discoideum DDB_G0270252 R-DDI-8874145 https://reactome.org/PathwayBrowser/#/R-DDI-8874145 MBTPS1 (S1P) cleaves ATF6B (ATF6-beta) IEA Dictyostelium discoideum DDB_G0270260 R-DDI-163296 https://reactome.org/PathwayBrowser/#/R-DDI-163296 Association of TFAM:mt promoter complex with POLRMT:TFB2M IEA Dictyostelium discoideum DDB_G0270260 R-DDI-163310 https://reactome.org/PathwayBrowser/#/R-DDI-163310 TFAM binds to mitochondrial promoters IEA Dictyostelium discoideum DDB_G0270260 R-DDI-266204 https://reactome.org/PathwayBrowser/#/R-DDI-266204 Association of HMGB1/HMGB2 with chromatin IEA Dictyostelium discoideum DDB_G0270260 R-DDI-6798748 https://reactome.org/PathwayBrowser/#/R-DDI-6798748 Exocytosis of secretory granule lumen proteins IEA Dictyostelium discoideum DDB_G0270260 R-DDI-6800434 https://reactome.org/PathwayBrowser/#/R-DDI-6800434 Exocytosis of ficolin-rich granule lumen proteins IEA Dictyostelium discoideum DDB_G0270260 R-DDI-6804099 https://reactome.org/PathwayBrowser/#/R-DDI-6804099 HMGB1 binds LTP IEA Dictyostelium discoideum DDB_G0270260 R-DDI-6804100 https://reactome.org/PathwayBrowser/#/R-DDI-6804100 HMGB1 binds LPS IEA Dictyostelium discoideum DDB_G0270260 R-DDI-6805981 https://reactome.org/PathwayBrowser/#/R-DDI-6805981 HMGB1 release from cells IEA Dictyostelium discoideum DDB_G0270260 R-DDI-879411 https://reactome.org/PathwayBrowser/#/R-DDI-879411 Advanced glycosylation end product-specific receptor (AGER/RAGE) is a multiligand receptor IEA Dictyostelium discoideum DDB_G0270260 R-DDI-9838081 https://reactome.org/PathwayBrowser/#/R-DDI-9838081 LONP1 degrades mitochondrial matrix proteins IEA Dictyostelium discoideum DDB_G0270260 R-DDI-9838093 https://reactome.org/PathwayBrowser/#/R-DDI-9838093 LONP1 binds mitochondrial matrix proteins IEA Dictyostelium discoideum DDB_G0270264 R-DDI-2534096 https://reactome.org/PathwayBrowser/#/R-DDI-2534096 METAP1/2 demethylates GNAT1 IEA Dictyostelium discoideum DDB_G0270266 R-DDI-68914 https://reactome.org/PathwayBrowser/#/R-DDI-68914 DNA polymerase alpha:primase binds at the origin IEA Dictyostelium discoideum DDB_G0270266 R-DDI-68917 https://reactome.org/PathwayBrowser/#/R-DDI-68917 Cdc45 associates with the pre-replicative complex at the origin IEA Dictyostelium discoideum DDB_G0270266 R-DDI-68960 https://reactome.org/PathwayBrowser/#/R-DDI-68960 DNA polymerase epsilon binds at the origin IEA Dictyostelium discoideum DDB_G0270270 R-DDI-548831 https://reactome.org/PathwayBrowser/#/R-DDI-548831 TECR,TECRL dehydrogenate TOD-CoA to ST-CoA IEA Dictyostelium discoideum DDB_G0270272 R-DDI-1169397 https://reactome.org/PathwayBrowser/#/R-DDI-1169397 Activation of ISG15 by UBA7 E1 ligase IEA Dictyostelium discoideum DDB_G0270272 R-DDI-1169404 https://reactome.org/PathwayBrowser/#/R-DDI-1169404 Transfer of ISG15 from E1 to E2 (UBCH8) IEA Dictyostelium discoideum DDB_G0270272 R-DDI-8852128 https://reactome.org/PathwayBrowser/#/R-DDI-8852128 UBA1 adenylates ubiquitin in the nucleoplasm IEA Dictyostelium discoideum DDB_G0270272 R-DDI-8852129 https://reactome.org/PathwayBrowser/#/R-DDI-8852129 UBA1 conjugates ubiquitin to cytosolic E2 enzymes IEA Dictyostelium discoideum DDB_G0270272 R-DDI-8852130 https://reactome.org/PathwayBrowser/#/R-DDI-8852130 UBA1 conjugates ubiquitin to nuclear E2 enzymes IEA Dictyostelium discoideum DDB_G0270272 R-DDI-8852131 https://reactome.org/PathwayBrowser/#/R-DDI-8852131 Ub-Cys632-UBA1 adenylates ubiquitin in the nucleus IEA Dictyostelium discoideum DDB_G0270272 R-DDI-8852132 https://reactome.org/PathwayBrowser/#/R-DDI-8852132 Ub-Cys632-UBA1 adenylates ubiquitin in the cytosol IEA Dictyostelium discoideum DDB_G0270272 R-DDI-8852133 https://reactome.org/PathwayBrowser/#/R-DDI-8852133 UBA1 conjugates ubiquitin to UBA1 in the cytosol IEA Dictyostelium discoideum DDB_G0270272 R-DDI-8852134 https://reactome.org/PathwayBrowser/#/R-DDI-8852134 UBA1 adenylates ubiquitin in the cytosol IEA Dictyostelium discoideum DDB_G0270272 R-DDI-8852136 https://reactome.org/PathwayBrowser/#/R-DDI-8852136 UBA1 conjugates ubiquitin to UBA1 in the nucleus IEA Dictyostelium discoideum DDB_G0270272 R-DDI-936563 https://reactome.org/PathwayBrowser/#/R-DDI-936563 ISGylation of DDX58 IEA Dictyostelium discoideum DDB_G0270272 R-DDI-983140 https://reactome.org/PathwayBrowser/#/R-DDI-983140 Transfer of Ub from E2 to substrate and release of E2 IEA Dictyostelium discoideum DDB_G0270272 R-DDI-983152 https://reactome.org/PathwayBrowser/#/R-DDI-983152 Transfer of ubiquitin from E1 to E2 IEA Dictyostelium discoideum DDB_G0270272 R-DDI-983153 https://reactome.org/PathwayBrowser/#/R-DDI-983153 E1 mediated ubiquitin activation IEA Dictyostelium discoideum DDB_G0270272 R-DDI-983156 https://reactome.org/PathwayBrowser/#/R-DDI-983156 Polyubiquitination of substrate IEA Dictyostelium discoideum DDB_G0270272 R-DDI-983157 https://reactome.org/PathwayBrowser/#/R-DDI-983157 Interaction of E3 with substrate and E2-Ub complex IEA Dictyostelium discoideum DDB_G0270298 R-DDI-1483190 https://reactome.org/PathwayBrowser/#/R-DDI-1483190 PETA and CTP are condensed to CDP-ETA by PCY2 IEA Dictyostelium discoideum DDB_G0270312 R-DDI-2046083 https://reactome.org/PathwayBrowser/#/R-DDI-2046083 Elongation of arachidonyl-CoA to docosatetraenoyl-CoA IEA Dictyostelium discoideum DDB_G0270312 R-DDI-2046088 https://reactome.org/PathwayBrowser/#/R-DDI-2046088 Elongation of stearidonoyl-CoA to eicosatetraenoyl-CoA IEA Dictyostelium discoideum DDB_G0270312 R-DDI-2046090 https://reactome.org/PathwayBrowser/#/R-DDI-2046090 Elongation of docosapentaenoyl-CoA to tetracosapentaenoyl-CoA IEA Dictyostelium discoideum DDB_G0270312 R-DDI-2046094 https://reactome.org/PathwayBrowser/#/R-DDI-2046094 Elongation of gamma-lenolenoyl-CoA to dihomo-gamma-lenolenoyl-CoA IEA Dictyostelium discoideum DDB_G0270312 R-DDI-2046095 https://reactome.org/PathwayBrowser/#/R-DDI-2046095 Elongation of docosatetraenoyl-CoA to tetracosatetraenoyl-CoA IEA Dictyostelium discoideum DDB_G0270312 R-DDI-2046100 https://reactome.org/PathwayBrowser/#/R-DDI-2046100 Elongation of eicosapentaenoyl-CoA to docosapentaenoyl-CoA IEA Dictyostelium discoideum DDB_G0270312 R-DDI-548800 https://reactome.org/PathwayBrowser/#/R-DDI-548800 ELOVL1,2,3,5 elongate AA-CoA and Mal-CoA to 3ODCT-CoA IEA Dictyostelium discoideum DDB_G0270316 R-DDI-156823 https://reactome.org/PathwayBrowser/#/R-DDI-156823 Association of phospho-L13a with GAIT element of Ceruloplasmin mRNA IEA Dictyostelium discoideum DDB_G0270316 R-DDI-1799332 https://reactome.org/PathwayBrowser/#/R-DDI-1799332 Nascent polypeptide:mRNA:ribosome complex binds signal recognition particle (SRP) IEA Dictyostelium discoideum DDB_G0270316 R-DDI-72621 https://reactome.org/PathwayBrowser/#/R-DDI-72621 Ribosomal scanning IEA Dictyostelium discoideum DDB_G0270316 R-DDI-72671 https://reactome.org/PathwayBrowser/#/R-DDI-72671 eIF5B:GTP is hydrolyzed and released IEA Dictyostelium discoideum DDB_G0270316 R-DDI-72672 https://reactome.org/PathwayBrowser/#/R-DDI-72672 The 60S subunit joins the translation initiation complex IEA Dictyostelium discoideum DDB_G0270316 R-DDI-72673 https://reactome.org/PathwayBrowser/#/R-DDI-72673 Release of 40S and 60S subunits from the 80S ribosome IEA Dictyostelium discoideum DDB_G0270316 R-DDI-72676 https://reactome.org/PathwayBrowser/#/R-DDI-72676 eIF3 and eIF1A bind to the 40S subunit IEA Dictyostelium discoideum DDB_G0270316 R-DDI-72691 https://reactome.org/PathwayBrowser/#/R-DDI-72691 Formation of the 43S pre-initiation complex IEA Dictyostelium discoideum DDB_G0270316 R-DDI-72697 https://reactome.org/PathwayBrowser/#/R-DDI-72697 Start codon recognition IEA Dictyostelium discoideum DDB_G0270316 R-DDI-927789 https://reactome.org/PathwayBrowser/#/R-DDI-927789 Formation of UPF1:eRF3 complex on mRNA with a premature termination codon and no Exon Junction Complex IEA Dictyostelium discoideum DDB_G0270316 R-DDI-927832 https://reactome.org/PathwayBrowser/#/R-DDI-927832 UPF1 binds an mRNP with a termination codon preceding an Exon Junction Complex IEA Dictyostelium discoideum DDB_G0270316 R-DDI-927889 https://reactome.org/PathwayBrowser/#/R-DDI-927889 SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex) IEA Dictyostelium discoideum DDB_G0270338 R-DDI-9701565 https://reactome.org/PathwayBrowser/#/R-DDI-9701565 HDACs deacetylate p-STAT3 dimers IEA Dictyostelium discoideum DDB_G0270340 R-DDI-6798747 https://reactome.org/PathwayBrowser/#/R-DDI-6798747 Exocytosis of tertiary granule membrane proteins IEA Dictyostelium discoideum DDB_G0270340 R-DDI-6799350 https://reactome.org/PathwayBrowser/#/R-DDI-6799350 Exocytosis of specific granule membrane proteins IEA Dictyostelium discoideum DDB_G0270358 R-DDI-8956099 https://reactome.org/PathwayBrowser/#/R-DDI-8956099 VHL:EloB,C:NEDD8-CUL2:RBX1 complex binds UBXN7 IEA Dictyostelium discoideum DDB_G0270358 R-DDI-9755306 https://reactome.org/PathwayBrowser/#/R-DDI-9755306 ub UBXN7 is degraded by the 26S proteasome IEA Dictyostelium discoideum DDB_G0270358 R-DDI-9755507 https://reactome.org/PathwayBrowser/#/R-DDI-9755507 UBXN7:UBF1:NPLOC4:VCP hexamer binds NFE2L2:CRL3 complex IEA Dictyostelium discoideum DDB_G0270358 R-DDI-9758088 https://reactome.org/PathwayBrowser/#/R-DDI-9758088 UBXN7 binds VCP hexamer:UBF1:NPLOC4 IEA Dictyostelium discoideum DDB_G0270360 R-DDI-9770236 https://reactome.org/PathwayBrowser/#/R-DDI-9770236 Formation of the Spliceosomal P complex and exon ligation IEA Dictyostelium discoideum DDB_G0270380 R-DDI-156826 https://reactome.org/PathwayBrowser/#/R-DDI-156826 Dissociation of L13a from the 60s ribosomal subunit IEA Dictyostelium discoideum DDB_G0270380 R-DDI-1799332 https://reactome.org/PathwayBrowser/#/R-DDI-1799332 Nascent polypeptide:mRNA:ribosome complex binds signal recognition particle (SRP) IEA Dictyostelium discoideum DDB_G0270380 R-DDI-72671 https://reactome.org/PathwayBrowser/#/R-DDI-72671 eIF5B:GTP is hydrolyzed and released IEA Dictyostelium discoideum DDB_G0270380 R-DDI-72672 https://reactome.org/PathwayBrowser/#/R-DDI-72672 The 60S subunit joins the translation initiation complex IEA Dictyostelium discoideum DDB_G0270380 R-DDI-72673 https://reactome.org/PathwayBrowser/#/R-DDI-72673 Release of 40S and 60S subunits from the 80S ribosome IEA Dictyostelium discoideum DDB_G0270380 R-DDI-927789 https://reactome.org/PathwayBrowser/#/R-DDI-927789 Formation of UPF1:eRF3 complex on mRNA with a premature termination codon and no Exon Junction Complex IEA Dictyostelium discoideum DDB_G0270380 R-DDI-927832 https://reactome.org/PathwayBrowser/#/R-DDI-927832 UPF1 binds an mRNP with a termination codon preceding an Exon Junction Complex IEA Dictyostelium discoideum DDB_G0270380 R-DDI-927889 https://reactome.org/PathwayBrowser/#/R-DDI-927889 SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex) IEA Dictyostelium discoideum DDB_G0270392 R-DDI-77589 https://reactome.org/PathwayBrowser/#/R-DDI-77589 Recognition of AAUAAA sequence by CPSF IEA Dictyostelium discoideum DDB_G0270392 R-DDI-77590 https://reactome.org/PathwayBrowser/#/R-DDI-77590 Recruitment of CstF to the CPSF Bound Pre-mRNA IEA Dictyostelium discoideum DDB_G0270398 R-DDI-165680 https://reactome.org/PathwayBrowser/#/R-DDI-165680 Formation of active mTORC1 complex IEA Dictyostelium discoideum DDB_G0270398 R-DDI-165692 https://reactome.org/PathwayBrowser/#/R-DDI-165692 Phosphorylation of 4E-BP1 by activated mTORC1 IEA Dictyostelium discoideum DDB_G0270398 R-DDI-165718 https://reactome.org/PathwayBrowser/#/R-DDI-165718 mTORC1 phosphorylation of RPS6KB1 (S6K) IEA Dictyostelium discoideum DDB_G0270398 R-DDI-377186 https://reactome.org/PathwayBrowser/#/R-DDI-377186 Activated Akt1 phosphorylates AKT1S1 (PRAS40) IEA Dictyostelium discoideum DDB_G0270398 R-DDI-380979 https://reactome.org/PathwayBrowser/#/R-DDI-380979 RHEB in mTORC1:RHEB:GTP hydrolyses GTP IEA Dictyostelium discoideum DDB_G0270398 R-DDI-447074 https://reactome.org/PathwayBrowser/#/R-DDI-447074 AMPK phosphorylates Raptor in the mTORC1 complex IEA Dictyostelium discoideum DDB_G0270398 R-DDI-5082405 https://reactome.org/PathwayBrowser/#/R-DDI-5082405 Phosphorylation of HSF1 at Ser326 induces transactivation IEA Dictyostelium discoideum DDB_G0270398 R-DDI-5653968 https://reactome.org/PathwayBrowser/#/R-DDI-5653968 Ragulator:Rag dimers:SLC38A9 bind mTORC1 IEA Dictyostelium discoideum DDB_G0270398 R-DDI-5672010 https://reactome.org/PathwayBrowser/#/R-DDI-5672010 Active MTORC1 phosphorylates ULK1 IEA Dictyostelium discoideum DDB_G0270398 R-DDI-5672017 https://reactome.org/PathwayBrowser/#/R-DDI-5672017 Rheb in the MTORC1 complex hydrolyses GTP IEA Dictyostelium discoideum DDB_G0270398 R-DDI-5672817 https://reactome.org/PathwayBrowser/#/R-DDI-5672817 Active MTORC1 binds the ULK1 complex IEA Dictyostelium discoideum DDB_G0270398 R-DDI-5672828 https://reactome.org/PathwayBrowser/#/R-DDI-5672828 mTORC1 phosphorylates AKT1S1 IEA Dictyostelium discoideum DDB_G0270398 R-DDI-5673768 https://reactome.org/PathwayBrowser/#/R-DDI-5673768 p-AMPK:AMP phosphorylates Raptor in the MTORC1 complex IEA Dictyostelium discoideum DDB_G0270398 R-DDI-5675790 https://reactome.org/PathwayBrowser/#/R-DDI-5675790 MTORC1 dissociates from ULK complex IEA Dictyostelium discoideum DDB_G0270398 R-DDI-8944454 https://reactome.org/PathwayBrowser/#/R-DDI-8944454 mTORC1 phosphorylates MAF1 IEA Dictyostelium discoideum DDB_G0270398 R-DDI-8944457 https://reactome.org/PathwayBrowser/#/R-DDI-8944457 MAF1 translocates to the nucleus IEA Dictyostelium discoideum DDB_G0270398 R-DDI-9640195 https://reactome.org/PathwayBrowser/#/R-DDI-9640195 RRAGA,B hydrolyzes GTP IEA Dictyostelium discoideum DDB_G0270398 R-DDI-9645608 https://reactome.org/PathwayBrowser/#/R-DDI-9645608 v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP binds mTORC1 IEA Dictyostelium discoideum DDB_G0270398 R-DDI-9646468 https://reactome.org/PathwayBrowser/#/R-DDI-9646468 mTORC1 binds RHEB:GTP IEA Dictyostelium discoideum DDB_G0270404 R-DDI-1011598 https://reactome.org/PathwayBrowser/#/R-DDI-1011598 DOCKs bind to RhoGEFs IEA Dictyostelium discoideum DDB_G0270404 R-DDI-6798749 https://reactome.org/PathwayBrowser/#/R-DDI-6798749 Exocytosis of specific granule lumen proteins IEA Dictyostelium discoideum DDB_G0270404 R-DDI-9013143 https://reactome.org/PathwayBrowser/#/R-DDI-9013143 RAC1 GEFs activate RAC1 IEA Dictyostelium discoideum DDB_G0270404 R-DDI-9014296 https://reactome.org/PathwayBrowser/#/R-DDI-9014296 RAC2 GEFs activate RAC2 IEA Dictyostelium discoideum DDB_G0270404 R-DDI-9014449 https://reactome.org/PathwayBrowser/#/R-DDI-9014449 RHOG binds effectors at the plasma membrane IEA Dictyostelium discoideum DDB_G0270406 R-DDI-1678842 https://reactome.org/PathwayBrowser/#/R-DDI-1678842 Competitive inhibition of translation initiation by ISGylated 4EHP IEA Dictyostelium discoideum DDB_G0270406 R-DDI-1678843 https://reactome.org/PathwayBrowser/#/R-DDI-1678843 ISGylation of protein translation regulator 4EHP IEA Dictyostelium discoideum DDB_G0270416 R-DDI-5690080 https://reactome.org/PathwayBrowser/#/R-DDI-5690080 USP3,SAGA deubiquitinate Histone H2A,H2B IEA Dictyostelium discoideum DDB_G0270416 R-DDI-5690157 https://reactome.org/PathwayBrowser/#/R-DDI-5690157 USP16,USP21 deubiquitinate Histone H2A IEA Dictyostelium discoideum DDB_G0270416 R-DDI-5690159 https://reactome.org/PathwayBrowser/#/R-DDI-5690159 USP21 deubiquitinates RIPK1,DDX58 IEA Dictyostelium discoideum DDB_G0270416 R-DDI-5696958 https://reactome.org/PathwayBrowser/#/R-DDI-5696958 USP44 deubiquitinates CDC20 IEA Dictyostelium discoideum DDB_G0270416 R-DDI-5696960 https://reactome.org/PathwayBrowser/#/R-DDI-5696960 USP49 deubiquitinates H2B IEA Dictyostelium discoideum DDB_G0270416 R-DDI-6783177 https://reactome.org/PathwayBrowser/#/R-DDI-6783177 USP21 deubiquitinates GATA3,IL33 IEA Dictyostelium discoideum DDB_G0270418 R-DDI-4641342 https://reactome.org/PathwayBrowser/#/R-DDI-4641342 SUMOylation of TOP2A with SUMO1 IEA Dictyostelium discoideum DDB_G0270418 R-DDI-4641345 https://reactome.org/PathwayBrowser/#/R-DDI-4641345 SUMOylation of TOP2B with SUMO1 IEA Dictyostelium discoideum DDB_G0270424 R-DDI-156826 https://reactome.org/PathwayBrowser/#/R-DDI-156826 Dissociation of L13a from the 60s ribosomal subunit IEA Dictyostelium discoideum DDB_G0270424 R-DDI-1799332 https://reactome.org/PathwayBrowser/#/R-DDI-1799332 Nascent polypeptide:mRNA:ribosome complex binds signal recognition particle (SRP) IEA Dictyostelium discoideum DDB_G0270424 R-DDI-72671 https://reactome.org/PathwayBrowser/#/R-DDI-72671 eIF5B:GTP is hydrolyzed and released IEA Dictyostelium discoideum DDB_G0270424 R-DDI-72672 https://reactome.org/PathwayBrowser/#/R-DDI-72672 The 60S subunit joins the translation initiation complex IEA Dictyostelium discoideum DDB_G0270424 R-DDI-72673 https://reactome.org/PathwayBrowser/#/R-DDI-72673 Release of 40S and 60S subunits from the 80S ribosome IEA Dictyostelium discoideum DDB_G0270424 R-DDI-927789 https://reactome.org/PathwayBrowser/#/R-DDI-927789 Formation of UPF1:eRF3 complex on mRNA with a premature termination codon and no Exon Junction Complex IEA Dictyostelium discoideum DDB_G0270424 R-DDI-927832 https://reactome.org/PathwayBrowser/#/R-DDI-927832 UPF1 binds an mRNP with a termination codon preceding an Exon Junction Complex IEA Dictyostelium discoideum DDB_G0270424 R-DDI-927889 https://reactome.org/PathwayBrowser/#/R-DDI-927889 SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex) IEA Dictyostelium discoideum DDB_G0270442 R-DDI-113504 https://reactome.org/PathwayBrowser/#/R-DDI-113504 Detection of damage during initiation of DNA synthesis in S-phase IEA Dictyostelium discoideum DDB_G0270442 R-DDI-68913 https://reactome.org/PathwayBrowser/#/R-DDI-68913 The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer at the origin IEA Dictyostelium discoideum DDB_G0270442 R-DDI-68914 https://reactome.org/PathwayBrowser/#/R-DDI-68914 DNA polymerase alpha:primase binds at the origin IEA Dictyostelium discoideum DDB_G0270442 R-DDI-68950 https://reactome.org/PathwayBrowser/#/R-DDI-68950 The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer at the origin IEA Dictyostelium discoideum DDB_G0270442 R-DDI-69053 https://reactome.org/PathwayBrowser/#/R-DDI-69053 RFC binding displaces Pol Alpha IEA Dictyostelium discoideum DDB_G0270442 R-DDI-69063 https://reactome.org/PathwayBrowser/#/R-DDI-69063 Loading of PCNA - Sliding Clamp Formation IEA Dictyostelium discoideum DDB_G0270442 R-DDI-69068 https://reactome.org/PathwayBrowser/#/R-DDI-69068 RFC dissociates after sliding clamp formation IEA Dictyostelium discoideum DDB_G0270442 R-DDI-69074 https://reactome.org/PathwayBrowser/#/R-DDI-69074 Formation of Processive Complex IEA Dictyostelium discoideum DDB_G0270442 R-DDI-69116 https://reactome.org/PathwayBrowser/#/R-DDI-69116 Formation of Okazaki fragments IEA Dictyostelium discoideum DDB_G0270442 R-DDI-69127 https://reactome.org/PathwayBrowser/#/R-DDI-69127 Formation of the Flap Intermediate IEA Dictyostelium discoideum DDB_G0270442 R-DDI-69142 https://reactome.org/PathwayBrowser/#/R-DDI-69142 Recruitment of Dna2 endonuclease IEA Dictyostelium discoideum DDB_G0270442 R-DDI-69152 https://reactome.org/PathwayBrowser/#/R-DDI-69152 Removal of remaining Flap IEA Dictyostelium discoideum DDB_G0270446 R-DDI-6814555 https://reactome.org/PathwayBrowser/#/R-DDI-6814555 Integrator complex processes the 3' end of snRNA IEA Dictyostelium discoideum DDB_G0270446 R-DDI-6814559 https://reactome.org/PathwayBrowser/#/R-DDI-6814559 Pre-snRNA is elongated and capped with 7-methylguanosine IEA Dictyostelium discoideum DDB_G0270450 R-DDI-9770236 https://reactome.org/PathwayBrowser/#/R-DDI-9770236 Formation of the Spliceosomal P complex and exon ligation IEA Dictyostelium discoideum DDB_G0270454 R-DDI-6798751 https://reactome.org/PathwayBrowser/#/R-DDI-6798751 Exocytosis of azurophil granule lumen proteins IEA Dictyostelium discoideum DDB_G0270454 R-DDI-8876472 https://reactome.org/PathwayBrowser/#/R-DDI-8876472 NPC2 binds CHOL IEA Dictyostelium discoideum DDB_G0270454 R-DDI-8876484 https://reactome.org/PathwayBrowser/#/R-DDI-8876484 NPC2 transfers CHOL to NPC1 IEA Dictyostelium discoideum DDB_G0270500 R-DDI-880007 https://reactome.org/PathwayBrowser/#/R-DDI-880007 (R)-2-hydroxyglutarate + FAD => 2-oxoglutarate + FADH2 IEA Dictyostelium discoideum DDB_G0270556 R-DDI-114684 https://reactome.org/PathwayBrowser/#/R-DDI-114684 Phosphorylation of Syntaxin-4 IEA Dictyostelium discoideum DDB_G0270556 R-DDI-376357 https://reactome.org/PathwayBrowser/#/R-DDI-376357 Vamp7 associated Lysosome to Plasma membrane transport IEA Dictyostelium discoideum DDB_G0270556 R-DDI-376364 https://reactome.org/PathwayBrowser/#/R-DDI-376364 Vamp8 associated secretory vesicle to plasma membrane transport IEA Dictyostelium discoideum DDB_G0270556 R-DDI-376369 https://reactome.org/PathwayBrowser/#/R-DDI-376369 Vamp2 associated secretory vesicle to plasma membrane transport IEA Dictyostelium discoideum DDB_G0270556 R-DDI-9014052 https://reactome.org/PathwayBrowser/#/R-DDI-9014052 TXLNA (IL14) binds syntaxin3 IEA Dictyostelium discoideum DDB_G0270556 R-DDI-9014074 https://reactome.org/PathwayBrowser/#/R-DDI-9014074 TXLNA (IL14) binds syntaxin4 IEA Dictyostelium discoideum DDB_G0270558 R-DDI-8933547 https://reactome.org/PathwayBrowser/#/R-DDI-8933547 MCAT transfers Mal from Mal-CoA to NDUFAB1 IEA Dictyostelium discoideum DDB_G0270562 R-DDI-5433074 https://reactome.org/PathwayBrowser/#/R-DDI-5433074 ACY1:Zn2+ dimer hydrolyses mercapturic acids IEA Dictyostelium discoideum DDB_G0270562 R-DDI-9753944 https://reactome.org/PathwayBrowser/#/R-DDI-9753944 ACY1:Zn2+ dimer deacetylates NAC to L-Cys IEA Dictyostelium discoideum DDB_G0270566 R-DDI-204008 https://reactome.org/PathwayBrowser/#/R-DDI-204008 SEC31:SEC13 and v-SNARE recruitment IEA Dictyostelium discoideum DDB_G0270566 R-DDI-5694409 https://reactome.org/PathwayBrowser/#/R-DDI-5694409 Nucleotide exchange on RAB1 IEA Dictyostelium discoideum DDB_G0270566 R-DDI-5694439 https://reactome.org/PathwayBrowser/#/R-DDI-5694439 COPII coat binds TRAPPCII and RAB1:GDP IEA Dictyostelium discoideum DDB_G0270566 R-DDI-5694441 https://reactome.org/PathwayBrowser/#/R-DDI-5694441 CSNK1D phosphorylates SEC23 IEA Dictyostelium discoideum DDB_G0270566 R-DDI-6786650 https://reactome.org/PathwayBrowser/#/R-DDI-6786650 DDHD1,2 hydrolyse PA IEA Dictyostelium discoideum DDB_G0270566 R-DDI-8869241 https://reactome.org/PathwayBrowser/#/R-DDI-8869241 PITPNM1,2,3 exchange PI for PA IEA Dictyostelium discoideum DDB_G0270582 R-DDI-9673053 https://reactome.org/PathwayBrowser/#/R-DDI-9673053 PM20D1 transforms oleoyl-phe from oleate and phe IEA Dictyostelium discoideum DDB_G0270582 R-DDI-9673054 https://reactome.org/PathwayBrowser/#/R-DDI-9673054 PM20D1 hydrolyzes oleoyl-phe IEA Dictyostelium discoideum DDB_G0270626 R-DDI-6798745 https://reactome.org/PathwayBrowser/#/R-DDI-6798745 Exocytosis of tertiary granule lumen proteins IEA Dictyostelium discoideum DDB_G0270626 R-DDI-6798749 https://reactome.org/PathwayBrowser/#/R-DDI-6798749 Exocytosis of specific granule lumen proteins IEA Dictyostelium discoideum DDB_G0270626 R-DDI-9861640 https://reactome.org/PathwayBrowser/#/R-DDI-9861640 CTLH E3 ligase ubiquitinates PKM-1 IEA Dictyostelium discoideum DDB_G0270636 R-DDI-5693356 https://reactome.org/PathwayBrowser/#/R-DDI-5693356 CEMIP hydrolyses HA IEA Dictyostelium discoideum DDB_G0270652 R-DDI-8936442 https://reactome.org/PathwayBrowser/#/R-DDI-8936442 MARC1,MARC2 reduce N-hydroxylated compounds IEA Dictyostelium discoideum DDB_G0270658 R-DDI-8848246 https://reactome.org/PathwayBrowser/#/R-DDI-8848246 DBI, ACBD7 bind MCFA-CoA and LCFA-CoA IEA Dictyostelium discoideum DDB_G0270670 R-DDI-6798743 https://reactome.org/PathwayBrowser/#/R-DDI-6798743 Exocytosis of secretory granule membrane proteins IEA Dictyostelium discoideum DDB_G0270670 R-DDI-983158 https://reactome.org/PathwayBrowser/#/R-DDI-983158 Trimming of peptides in ER IEA Dictyostelium discoideum DDB_G0270670 R-DDI-983162 https://reactome.org/PathwayBrowser/#/R-DDI-983162 Trimming of N-ter extended precursor fragments by cytosolic aminopeptidases IEA Dictyostelium discoideum DDB_G0270688 R-DDI-203797 https://reactome.org/PathwayBrowser/#/R-DDI-203797 ERKs are inactivated by dual-specific phosphatases (DUSPs) IEA Dictyostelium discoideum DDB_G0270688 R-DDI-5675373 https://reactome.org/PathwayBrowser/#/R-DDI-5675373 Nuclear DUSPs dephosphorylate MAPKs IEA Dictyostelium discoideum DDB_G0270688 R-DDI-5675376 https://reactome.org/PathwayBrowser/#/R-DDI-5675376 Cytosolic DUSPs dephosphorylate MAPKs IEA Dictyostelium discoideum DDB_G0270764 R-DDI-110246 https://reactome.org/PathwayBrowser/#/R-DDI-110246 Cleavage of adenine mispaired with 8-oxoguanine by MUTYH IEA Dictyostelium discoideum DDB_G0270764 R-DDI-110355 https://reactome.org/PathwayBrowser/#/R-DDI-110355 Displacement of MUTYH glycosylase by APEX1 at the AP site IEA Dictyostelium discoideum DDB_G0270784 R-DDI-1236970 https://reactome.org/PathwayBrowser/#/R-DDI-1236970 Proteasomal clevage of exogenous antigen (26S proteasome catalyst) IEA Dictyostelium discoideum DDB_G0270784 R-DDI-1504193 https://reactome.org/PathwayBrowser/#/R-DDI-1504193 Ubiquitinated DVL is degraded by the proteasome IEA Dictyostelium discoideum DDB_G0270784 R-DDI-174058 https://reactome.org/PathwayBrowser/#/R-DDI-174058 Degradation of multiubiquitinated Cdh1 IEA Dictyostelium discoideum DDB_G0270784 R-DDI-174105 https://reactome.org/PathwayBrowser/#/R-DDI-174105 Degradation of multiubiquitinated cell cycle proteins IEA Dictyostelium discoideum DDB_G0270784 R-DDI-174202 https://reactome.org/PathwayBrowser/#/R-DDI-174202 Degradation of multiubiquitinated Securin IEA Dictyostelium discoideum DDB_G0270784 R-DDI-188191 https://reactome.org/PathwayBrowser/#/R-DDI-188191 APC/C:Cdh1-mediated degradation of Skp2 IEA Dictyostelium discoideum DDB_G0270784 R-DDI-264458 https://reactome.org/PathwayBrowser/#/R-DDI-264458 Proteasome mediated degradation of COP1 IEA Dictyostelium discoideum DDB_G0270784 R-DDI-450466 https://reactome.org/PathwayBrowser/#/R-DDI-450466 AUF1:mRNA complex is destroyed IEA Dictyostelium discoideum DDB_G0270784 R-DDI-5635854 https://reactome.org/PathwayBrowser/#/R-DDI-5635854 GLI2,3 are degraded by the proteasome IEA Dictyostelium discoideum DDB_G0270784 R-DDI-5658430 https://reactome.org/PathwayBrowser/#/R-DDI-5658430 NF1 is degraded by the proteasome IEA Dictyostelium discoideum DDB_G0270784 R-DDI-5665854 https://reactome.org/PathwayBrowser/#/R-DDI-5665854 ADRM1:26S proteaseome binds UCHL5 IEA Dictyostelium discoideum DDB_G0270784 R-DDI-5665871 https://reactome.org/PathwayBrowser/#/R-DDI-5665871 ADRM1 binds 26S proteasome IEA Dictyostelium discoideum DDB_G0270784 R-DDI-5687112 https://reactome.org/PathwayBrowser/#/R-DDI-5687112 MAPK6 is degraded by the 26S proteasome IEA Dictyostelium discoideum DDB_G0270784 R-DDI-5689539 https://reactome.org/PathwayBrowser/#/R-DDI-5689539 ADRM1:26S proteaseome binds USP14 IEA Dictyostelium discoideum DDB_G0270784 R-DDI-68948 https://reactome.org/PathwayBrowser/#/R-DDI-68948 Ubiquitinated Orc1 is degraded by the proteasome IEA Dictyostelium discoideum DDB_G0270784 R-DDI-69016 https://reactome.org/PathwayBrowser/#/R-DDI-69016 Ubiquitinated Cdc6 is degraded by the proteasome IEA Dictyostelium discoideum DDB_G0270784 R-DDI-69600 https://reactome.org/PathwayBrowser/#/R-DDI-69600 Proteolytic degradation of ubiquitinated-Cdc25A IEA Dictyostelium discoideum DDB_G0270784 R-DDI-8850992 https://reactome.org/PathwayBrowser/#/R-DDI-8850992 Proteasome degrades polyubiquitinated PTEN IEA Dictyostelium discoideum DDB_G0270784 R-DDI-8854044 https://reactome.org/PathwayBrowser/#/R-DDI-8854044 Proteasome degrades AURKA ubiquitinated by SCF-FBXL7 IEA Dictyostelium discoideum DDB_G0270784 R-DDI-8866553 https://reactome.org/PathwayBrowser/#/R-DDI-8866553 misfolded CFTR is degraded by the 26S proteasome IEA Dictyostelium discoideum DDB_G0270784 R-DDI-9755306 https://reactome.org/PathwayBrowser/#/R-DDI-9755306 ub UBXN7 is degraded by the 26S proteasome IEA Dictyostelium discoideum DDB_G0270784 R-DDI-983150 https://reactome.org/PathwayBrowser/#/R-DDI-983150 Proteasomal cleavage of substrate IEA Dictyostelium discoideum DDB_G0270784 R-DDI-9907954 https://reactome.org/PathwayBrowser/#/R-DDI-9907954 PSMC2 binds PSMC1 IEA Dictyostelium discoideum DDB_G0270784 R-DDI-9907976 https://reactome.org/PathwayBrowser/#/R-DDI-9907976 PSMD5 and PSMD2 bind PSMC2:PSMC1 IEA Dictyostelium discoideum DDB_G0270784 R-DDI-9907980 https://reactome.org/PathwayBrowser/#/R-DDI-9907980 Formation of the 19S regulatory particle base precursor IEA Dictyostelium discoideum DDB_G0270784 R-DDI-9908026 https://reactome.org/PathwayBrowser/#/R-DDI-9908026 Formation of the 19S regulatory particle precursor IEA Dictyostelium discoideum DDB_G0270784 R-DDI-9908178 https://reactome.org/PathwayBrowser/#/R-DDI-9908178 Formation of the 26S proteasome IEA Dictyostelium discoideum DDB_G0270806 R-DDI-8986181 https://reactome.org/PathwayBrowser/#/R-DDI-8986181 PITRM1 proteolyzes mitochondrial targeting peptides (presequences) IEA Dictyostelium discoideum DDB_G0270806 R-DDI-9837978 https://reactome.org/PathwayBrowser/#/R-DDI-9837978 LONP1 binds mitochondrial inner membrane proteins IEA Dictyostelium discoideum DDB_G0270806 R-DDI-9838004 https://reactome.org/PathwayBrowser/#/R-DDI-9838004 LONP1 degrades mitochondrial inner membrane proteins IEA Dictyostelium discoideum DDB_G0270814 R-DDI-179410 https://reactome.org/PathwayBrowser/#/R-DDI-179410 Association of Nek2A with MCC:APC/C IEA Dictyostelium discoideum DDB_G0270814 R-DDI-179417 https://reactome.org/PathwayBrowser/#/R-DDI-179417 Multiubiquitination of Nek2A IEA Dictyostelium discoideum DDB_G0270814 R-DDI-179421 https://reactome.org/PathwayBrowser/#/R-DDI-179421 Degradation of multiubiquitinated Nek2A IEA Dictyostelium discoideum DDB_G0270826 R-DDI-265783 https://reactome.org/PathwayBrowser/#/R-DDI-265783 ABCG5:ABCG8 transports sterols from cytosol to extracellular region IEA Dictyostelium discoideum DDB_G0270826 R-DDI-917979 https://reactome.org/PathwayBrowser/#/R-DDI-917979 ABCG2 tetramer transports heme from cytosol to extracellular region IEA Dictyostelium discoideum DDB_G0270826 R-DDI-9661417 https://reactome.org/PathwayBrowser/#/R-DDI-9661417 ABCG2 tetramer transports BMG,BDG from cytosol to extracellular region IEA Dictyostelium discoideum DDB_G0270826 R-DDI-9753278 https://reactome.org/PathwayBrowser/#/R-DDI-9753278 ABCC2,ABCG2 transport APAP-GlcA, APAP-SO3 IEA Dictyostelium discoideum DDB_G0270826 R-DDI-9794120 https://reactome.org/PathwayBrowser/#/R-DDI-9794120 ABCG2 transports Cipro from intestinal cell to extracellular space IEA Dictyostelium discoideum DDB_G0270826 R-DDI-9794572 https://reactome.org/PathwayBrowser/#/R-DDI-9794572 ABCG2 transports Cipro from hepatic cell to extracellular space IEA Dictyostelium discoideum DDB_G0270826 R-DDI-9843721 https://reactome.org/PathwayBrowser/#/R-DDI-9843721 ABCC1,ABCG2 transport C18-S1P to extracellular region IEA Dictyostelium discoideum DDB_G0270828 R-DDI-6791219 https://reactome.org/PathwayBrowser/#/R-DDI-6791219 32S pre-rRNA is nucleolytically processed at site 4 (4a) to yield 12S pre-rRNA and 28S rRNA IEA Dictyostelium discoideum DDB_G0270830 R-DDI-4827383 https://reactome.org/PathwayBrowser/#/R-DDI-4827383 WHSC1 (KMT3G), NSD1 (KMT3B), SMYD2 (KMT3C) methylate lysine-37 of histone H3 (H3K36) IEA Dictyostelium discoideum DDB_G0270830 R-DDI-5638157 https://reactome.org/PathwayBrowser/#/R-DDI-5638157 WHSC1 (KMT3G), NSD1 (KMT3B), SMYD2 (KMT3C), ASH1L methylate methyl-lysine-37 of histone H3 (H3K36) IEA Dictyostelium discoideum DDB_G0270834 R-DDI-1605797 https://reactome.org/PathwayBrowser/#/R-DDI-1605797 SMPD1 hydrolyzes SPHM IEA Dictyostelium discoideum DDB_G0270836 R-DDI-70479 https://reactome.org/PathwayBrowser/#/R-DDI-70479 FBP tetramers hydrolyze F1,6PP to Fru(6)P IEA Dictyostelium discoideum DDB_G0270858 R-DDI-418582 https://reactome.org/PathwayBrowser/#/R-DDI-418582 G alpha (q) auto-inactivates by hydrolysing GTP to GDP IEA Dictyostelium discoideum DDB_G0270858 R-DDI-8981892 https://reactome.org/PathwayBrowser/#/R-DDI-8981892 Active G alpha (z) binds RGS proteins IEA Dictyostelium discoideum DDB_G0270858 R-DDI-8982012 https://reactome.org/PathwayBrowser/#/R-DDI-8982012 G alpha (i):RGS dissociates to inactive G alpha (i)–i1/i2/i3 IEA Dictyostelium discoideum DDB_G0270858 R-DDI-8982017 https://reactome.org/PathwayBrowser/#/R-DDI-8982017 Active G alpha (q) binds RGS proteins IEA Dictyostelium discoideum DDB_G0270858 R-DDI-8982018 https://reactome.org/PathwayBrowser/#/R-DDI-8982018 G alpha (z):RGS complex dissociates to give inactive G alpha (z) IEA Dictyostelium discoideum DDB_G0270858 R-DDI-8982019 https://reactome.org/PathwayBrowser/#/R-DDI-8982019 Active G alpha (i)–i1/i2/i3 binds RGS proteins IEA Dictyostelium discoideum DDB_G0270858 R-DDI-8982020 https://reactome.org/PathwayBrowser/#/R-DDI-8982020 G alpha (i)–i1/i2/i3 in G (i):RGS complex is inactivated IEA Dictyostelium discoideum DDB_G0270858 R-DDI-8982021 https://reactome.org/PathwayBrowser/#/R-DDI-8982021 G alpha (z) in G alpha (z):RGS complex is inactivated IEA Dictyostelium discoideum DDB_G0270858 R-DDI-8982025 https://reactome.org/PathwayBrowser/#/R-DDI-8982025 G alpha (q) in G (q):RGS complex is inactivated IEA Dictyostelium discoideum DDB_G0270858 R-DDI-8982026 https://reactome.org/PathwayBrowser/#/R-DDI-8982026 G alpha (q):RGS dissociates to inactive G alpha (q) IEA Dictyostelium discoideum DDB_G0270866 R-DDI-927832 https://reactome.org/PathwayBrowser/#/R-DDI-927832 UPF1 binds an mRNP with a termination codon preceding an Exon Junction Complex IEA Dictyostelium discoideum DDB_G0270866 R-DDI-927889 https://reactome.org/PathwayBrowser/#/R-DDI-927889 SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex) IEA Dictyostelium discoideum DDB_G0270866 R-DDI-9770236 https://reactome.org/PathwayBrowser/#/R-DDI-9770236 Formation of the Spliceosomal P complex and exon ligation IEA Dictyostelium discoideum DDB_G0270870 R-DDI-939763 https://reactome.org/PathwayBrowser/#/R-DDI-939763 P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane IEA Dictyostelium discoideum DDB_G0270870 R-DDI-947591 https://reactome.org/PathwayBrowser/#/R-DDI-947591 P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane IEA Dictyostelium discoideum DDB_G0270880 R-DDI-9821475 https://reactome.org/PathwayBrowser/#/R-DDI-9821475 CXXC1 and WDR82 bind SET1A complex IEA Dictyostelium discoideum DDB_G0270880 R-DDI-9821476 https://reactome.org/PathwayBrowser/#/R-DDI-9821476 CXXC1 and WDR82 bind SET1B complex IEA Dictyostelium discoideum DDB_G0270882 R-DDI-203553 https://reactome.org/PathwayBrowser/#/R-DDI-203553 eNOS binds NOSIP IEA Dictyostelium discoideum DDB_G0270882 R-DDI-203680 https://reactome.org/PathwayBrowser/#/R-DDI-203680 eNOS:NOSIP translocation from caveolae to intracellular compartments IEA Dictyostelium discoideum DDB_G0270906 R-DDI-9629869 https://reactome.org/PathwayBrowser/#/R-DDI-9629869 KDM8:Fe2+ hydroxylates an arginine residue of RPS6 IEA Dictyostelium discoideum DDB_G0270910 R-DDI-1678842 https://reactome.org/PathwayBrowser/#/R-DDI-1678842 Competitive inhibition of translation initiation by ISGylated 4EHP IEA Dictyostelium discoideum DDB_G0270910 R-DDI-1678843 https://reactome.org/PathwayBrowser/#/R-DDI-1678843 ISGylation of protein translation regulator 4EHP IEA Dictyostelium discoideum DDB_G0270918 R-DDI-8876191 https://reactome.org/PathwayBrowser/#/R-DDI-8876191 RAB9 GEFs exchange GTP for GDP on RAB9 IEA Dictyostelium discoideum DDB_G0270918 R-DDI-8876615 https://reactome.org/PathwayBrowser/#/R-DDI-8876615 RAB13 GEFs exchange GTP for GDP on RAB13 IEA Dictyostelium discoideum DDB_G0270928 R-DDI-5688294 https://reactome.org/PathwayBrowser/#/R-DDI-5688294 SIRT5 deacetylates Cytochrome C IEA Dictyostelium discoideum DDB_G0270946 R-DDI-191983 https://reactome.org/PathwayBrowser/#/R-DDI-191983 Cholesterol is hydroxylated to 25-hydroxycholesterol IEA Dictyostelium discoideum DDB_G0270948 R-DDI-9647987 https://reactome.org/PathwayBrowser/#/R-DDI-9647987 FNTB inhibitors bind FNTA:FNTB IEA Dictyostelium discoideum DDB_G0270984 R-DDI-156826 https://reactome.org/PathwayBrowser/#/R-DDI-156826 Dissociation of L13a from the 60s ribosomal subunit IEA Dictyostelium discoideum DDB_G0270984 R-DDI-1799332 https://reactome.org/PathwayBrowser/#/R-DDI-1799332 Nascent polypeptide:mRNA:ribosome complex binds signal recognition particle (SRP) IEA Dictyostelium discoideum DDB_G0270984 R-DDI-72671 https://reactome.org/PathwayBrowser/#/R-DDI-72671 eIF5B:GTP is hydrolyzed and released IEA Dictyostelium discoideum DDB_G0270984 R-DDI-72672 https://reactome.org/PathwayBrowser/#/R-DDI-72672 The 60S subunit joins the translation initiation complex IEA Dictyostelium discoideum DDB_G0270984 R-DDI-72673 https://reactome.org/PathwayBrowser/#/R-DDI-72673 Release of 40S and 60S subunits from the 80S ribosome IEA Dictyostelium discoideum DDB_G0270984 R-DDI-927789 https://reactome.org/PathwayBrowser/#/R-DDI-927789 Formation of UPF1:eRF3 complex on mRNA with a premature termination codon and no Exon Junction Complex IEA Dictyostelium discoideum DDB_G0270984 R-DDI-927832 https://reactome.org/PathwayBrowser/#/R-DDI-927832 UPF1 binds an mRNP with a termination codon preceding an Exon Junction Complex IEA Dictyostelium discoideum DDB_G0270984 R-DDI-927889 https://reactome.org/PathwayBrowser/#/R-DDI-927889 SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex) IEA Dictyostelium discoideum DDB_G0270990 R-DDI-389889 https://reactome.org/PathwayBrowser/#/R-DDI-389889 ACOX2:FAD, ACOXL:FAD oxidise (2S)-pristanoyl-CoA to trans-2,3-dehydropristanoyl-CoA IEA Dictyostelium discoideum DDB_G0270992 R-DDI-204008 https://reactome.org/PathwayBrowser/#/R-DDI-204008 SEC31:SEC13 and v-SNARE recruitment IEA Dictyostelium discoideum DDB_G0270992 R-DDI-5694409 https://reactome.org/PathwayBrowser/#/R-DDI-5694409 Nucleotide exchange on RAB1 IEA Dictyostelium discoideum DDB_G0270992 R-DDI-5694439 https://reactome.org/PathwayBrowser/#/R-DDI-5694439 COPII coat binds TRAPPCII and RAB1:GDP IEA Dictyostelium discoideum DDB_G0270992 R-DDI-5694441 https://reactome.org/PathwayBrowser/#/R-DDI-5694441 CSNK1D phosphorylates SEC23 IEA Dictyostelium discoideum DDB_G0270994 R-DDI-6798743 https://reactome.org/PathwayBrowser/#/R-DDI-6798743 Exocytosis of secretory granule membrane proteins IEA Dictyostelium discoideum DDB_G0270994 R-DDI-983158 https://reactome.org/PathwayBrowser/#/R-DDI-983158 Trimming of peptides in ER IEA Dictyostelium discoideum DDB_G0270994 R-DDI-983162 https://reactome.org/PathwayBrowser/#/R-DDI-983162 Trimming of N-ter extended precursor fragments by cytosolic aminopeptidases IEA Dictyostelium discoideum DDB_G0271040 R-DDI-6814555 https://reactome.org/PathwayBrowser/#/R-DDI-6814555 Integrator complex processes the 3' end of snRNA IEA Dictyostelium discoideum DDB_G0271040 R-DDI-6814559 https://reactome.org/PathwayBrowser/#/R-DDI-6814559 Pre-snRNA is elongated and capped with 7-methylguanosine IEA Dictyostelium discoideum DDB_G0271052 R-DDI-3215448 https://reactome.org/PathwayBrowser/#/R-DDI-3215448 SWI/SNF chromatin remodelling complex enhances MEP50:PRMT5 methyltransferase activity IEA Dictyostelium discoideum DDB_G0271052 R-DDI-5205799 https://reactome.org/PathwayBrowser/#/R-DDI-5205799 CCND1:CDK4:PRMT5:pT5-WDR77 methylates arginine-9 of histone H3 (H3R8) IEA Dictyostelium discoideum DDB_G0271052 R-DDI-8865605 https://reactome.org/PathwayBrowser/#/R-DDI-8865605 BRWD1 binds SMARCA4 IEA Dictyostelium discoideum DDB_G0271066 R-DDI-2046083 https://reactome.org/PathwayBrowser/#/R-DDI-2046083 Elongation of arachidonyl-CoA to docosatetraenoyl-CoA IEA Dictyostelium discoideum DDB_G0271066 R-DDI-2046088 https://reactome.org/PathwayBrowser/#/R-DDI-2046088 Elongation of stearidonoyl-CoA to eicosatetraenoyl-CoA IEA Dictyostelium discoideum DDB_G0271066 R-DDI-2046090 https://reactome.org/PathwayBrowser/#/R-DDI-2046090 Elongation of docosapentaenoyl-CoA to tetracosapentaenoyl-CoA IEA Dictyostelium discoideum DDB_G0271066 R-DDI-2046094 https://reactome.org/PathwayBrowser/#/R-DDI-2046094 Elongation of gamma-lenolenoyl-CoA to dihomo-gamma-lenolenoyl-CoA IEA Dictyostelium discoideum DDB_G0271066 R-DDI-2046095 https://reactome.org/PathwayBrowser/#/R-DDI-2046095 Elongation of docosatetraenoyl-CoA to tetracosatetraenoyl-CoA IEA Dictyostelium discoideum DDB_G0271066 R-DDI-2046100 https://reactome.org/PathwayBrowser/#/R-DDI-2046100 Elongation of eicosapentaenoyl-CoA to docosapentaenoyl-CoA IEA Dictyostelium discoideum DDB_G0271066 R-DDI-548800 https://reactome.org/PathwayBrowser/#/R-DDI-548800 ELOVL1,2,3,5 elongate AA-CoA and Mal-CoA to 3ODCT-CoA IEA Dictyostelium discoideum DDB_G0271078 R-DDI-68595 https://reactome.org/PathwayBrowser/#/R-DDI-68595 ORC2 binds ORC3 IEA Dictyostelium discoideum DDB_G0271078 R-DDI-68603 https://reactome.org/PathwayBrowser/#/R-DDI-68603 ORC5 binds ORC2:ORC3 IEA Dictyostelium discoideum DDB_G0271078 R-DDI-68610 https://reactome.org/PathwayBrowser/#/R-DDI-68610 Formation of ORC(2-5) complex IEA Dictyostelium discoideum DDB_G0271078 R-DDI-68611 https://reactome.org/PathwayBrowser/#/R-DDI-68611 Formation of ORC(1-5) complex IEA Dictyostelium discoideum DDB_G0271078 R-DDI-68615 https://reactome.org/PathwayBrowser/#/R-DDI-68615 Formation of ORC(1-6) complex IEA Dictyostelium discoideum DDB_G0271078 R-DDI-68688 https://reactome.org/PathwayBrowser/#/R-DDI-68688 CDC6 association with ORC(1-6) at replication origins IEA Dictyostelium discoideum DDB_G0271078 R-DDI-68914 https://reactome.org/PathwayBrowser/#/R-DDI-68914 DNA polymerase alpha:primase binds at the origin IEA Dictyostelium discoideum DDB_G0271078 R-DDI-68917 https://reactome.org/PathwayBrowser/#/R-DDI-68917 Cdc45 associates with the pre-replicative complex at the origin IEA Dictyostelium discoideum DDB_G0271078 R-DDI-68960 https://reactome.org/PathwayBrowser/#/R-DDI-68960 DNA polymerase epsilon binds at the origin IEA Dictyostelium discoideum DDB_G0271094 R-DDI-71181 https://reactome.org/PathwayBrowser/#/R-DDI-71181 FAH cleaves 4FAA IEA Dictyostelium discoideum DDB_G0271096 R-DDI-5681980 https://reactome.org/PathwayBrowser/#/R-DDI-5681980 ATG12 binds ATG7 dimer IEA Dictyostelium discoideum DDB_G0271096 R-DDI-5681981 https://reactome.org/PathwayBrowser/#/R-DDI-5681981 ATG3 transfers LC3 from ATG7 to ATG3 IEA Dictyostelium discoideum DDB_G0271096 R-DDI-5682011 https://reactome.org/PathwayBrowser/#/R-DDI-5682011 LC3 binds ATG7 dimer IEA Dictyostelium discoideum DDB_G0271096 R-DDI-5682896 https://reactome.org/PathwayBrowser/#/R-DDI-5682896 LC3:ATG7 dimer binds ATG3 IEA Dictyostelium discoideum DDB_G0271096 R-DDI-5683593 https://reactome.org/PathwayBrowser/#/R-DDI-5683593 ATG7:ATG3:LC3 dissociates IEA Dictyostelium discoideum DDB_G0271096 R-DDI-6798748 https://reactome.org/PathwayBrowser/#/R-DDI-6798748 Exocytosis of secretory granule lumen proteins IEA Dictyostelium discoideum DDB_G0271096 R-DDI-6800434 https://reactome.org/PathwayBrowser/#/R-DDI-6800434 Exocytosis of ficolin-rich granule lumen proteins IEA Dictyostelium discoideum DDB_G0271096 R-DDI-9020616 https://reactome.org/PathwayBrowser/#/R-DDI-9020616 ATG12 forms a thioester bond with ATG7 dimer IEA Dictyostelium discoideum DDB_G0271096 R-DDI-983152 https://reactome.org/PathwayBrowser/#/R-DDI-983152 Transfer of ubiquitin from E1 to E2 IEA Dictyostelium discoideum DDB_G0271096 R-DDI-983153 https://reactome.org/PathwayBrowser/#/R-DDI-983153 E1 mediated ubiquitin activation IEA Dictyostelium discoideum DDB_G0271100 R-DDI-430028 https://reactome.org/PathwayBrowser/#/R-DDI-430028 Exosome Complex hydrolyzes mRNA by 3' to 5' exoribonuclease digestion IEA Dictyostelium discoideum DDB_G0271100 R-DDI-450431 https://reactome.org/PathwayBrowser/#/R-DDI-450431 ZFP36 (TTP) recruits RNA degradation activities IEA Dictyostelium discoideum DDB_G0271100 R-DDI-450488 https://reactome.org/PathwayBrowser/#/R-DDI-450488 BRF1 Complex recruits RNA degradation activities IEA Dictyostelium discoideum DDB_G0271100 R-DDI-6791222 https://reactome.org/PathwayBrowser/#/R-DDI-6791222 21S pre-rRNA is nucleolytically processed at site E (site2a) to yield 18SE pre-rRNA IEA Dictyostelium discoideum DDB_G0271106 R-DDI-3299680 https://reactome.org/PathwayBrowser/#/R-DDI-3299680 SOD2 catalyzes 2H+ + 2O2.- => O2 + H2O2 (mitochondrial matrix) IEA Dictyostelium discoideum DDB_G0271106 R-DDI-5688289 https://reactome.org/PathwayBrowser/#/R-DDI-5688289 SIRT3 deacetylates ACCS2, GLUD, IDH2, SOD2 IEA Dictyostelium discoideum DDB_G0271122 R-DDI-9755507 https://reactome.org/PathwayBrowser/#/R-DDI-9755507 UBXN7:UBF1:NPLOC4:VCP hexamer binds NFE2L2:CRL3 complex IEA Dictyostelium discoideum DDB_G0271122 R-DDI-9758088 https://reactome.org/PathwayBrowser/#/R-DDI-9758088 UBXN7 binds VCP hexamer:UBF1:NPLOC4 IEA Dictyostelium discoideum DDB_G0271144 R-DDI-901047 https://reactome.org/PathwayBrowser/#/R-DDI-901047 Binding of ERp57 IEA Dictyostelium discoideum DDB_G0271146 R-DDI-73599 https://reactome.org/PathwayBrowser/#/R-DDI-73599 cytidine or uridine + ATP => CMP or UMP + ADP [UCK1] IEA Dictyostelium discoideum DDB_G0271146 R-DDI-8869606 https://reactome.org/PathwayBrowser/#/R-DDI-8869606 NMRK1 phosphorylates NAR to yield NAMN IEA Dictyostelium discoideum DDB_G0271146 R-DDI-8869607 https://reactome.org/PathwayBrowser/#/R-DDI-8869607 NMRK2 phosphorylates NAR to yield NAMN IEA Dictyostelium discoideum DDB_G0271146 R-DDI-8869627 https://reactome.org/PathwayBrowser/#/R-DDI-8869627 NMRK2 phosphorylates NR to yield NMN IEA Dictyostelium discoideum DDB_G0271146 R-DDI-8869633 https://reactome.org/PathwayBrowser/#/R-DDI-8869633 NMRK1 phosphorylates NR to yield NMN IEA Dictyostelium discoideum DDB_G0271148 R-DDI-156823 https://reactome.org/PathwayBrowser/#/R-DDI-156823 Association of phospho-L13a with GAIT element of Ceruloplasmin mRNA IEA Dictyostelium discoideum DDB_G0271148 R-DDI-1799332 https://reactome.org/PathwayBrowser/#/R-DDI-1799332 Nascent polypeptide:mRNA:ribosome complex binds signal recognition particle (SRP) IEA Dictyostelium discoideum DDB_G0271148 R-DDI-72621 https://reactome.org/PathwayBrowser/#/R-DDI-72621 Ribosomal scanning IEA Dictyostelium discoideum DDB_G0271148 R-DDI-72671 https://reactome.org/PathwayBrowser/#/R-DDI-72671 eIF5B:GTP is hydrolyzed and released IEA Dictyostelium discoideum DDB_G0271148 R-DDI-72672 https://reactome.org/PathwayBrowser/#/R-DDI-72672 The 60S subunit joins the translation initiation complex IEA Dictyostelium discoideum DDB_G0271148 R-DDI-72673 https://reactome.org/PathwayBrowser/#/R-DDI-72673 Release of 40S and 60S subunits from the 80S ribosome IEA Dictyostelium discoideum DDB_G0271148 R-DDI-72676 https://reactome.org/PathwayBrowser/#/R-DDI-72676 eIF3 and eIF1A bind to the 40S subunit IEA Dictyostelium discoideum DDB_G0271148 R-DDI-72691 https://reactome.org/PathwayBrowser/#/R-DDI-72691 Formation of the 43S pre-initiation complex IEA Dictyostelium discoideum DDB_G0271148 R-DDI-72697 https://reactome.org/PathwayBrowser/#/R-DDI-72697 Start codon recognition IEA Dictyostelium discoideum DDB_G0271148 R-DDI-927789 https://reactome.org/PathwayBrowser/#/R-DDI-927789 Formation of UPF1:eRF3 complex on mRNA with a premature termination codon and no Exon Junction Complex IEA Dictyostelium discoideum DDB_G0271148 R-DDI-927832 https://reactome.org/PathwayBrowser/#/R-DDI-927832 UPF1 binds an mRNP with a termination codon preceding an Exon Junction Complex IEA Dictyostelium discoideum DDB_G0271148 R-DDI-927889 https://reactome.org/PathwayBrowser/#/R-DDI-927889 SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex) IEA Dictyostelium discoideum DDB_G0271240 R-DDI-6791222 https://reactome.org/PathwayBrowser/#/R-DDI-6791222 21S pre-rRNA is nucleolytically processed at site E (site2a) to yield 18SE pre-rRNA IEA Dictyostelium discoideum DDB_G0271240 R-DDI-6791227 https://reactome.org/PathwayBrowser/#/R-DDI-6791227 47S pre-rRNA is nucleolytically processed at A' (01,A1), site A0, and site 02 (site 6) to yield 45S pre-rRNA IEA Dictyostelium discoideum DDB_G0271242 R-DDI-166015 https://reactome.org/PathwayBrowser/#/R-DDI-166015 Association of LBP with LPS IEA Dictyostelium discoideum DDB_G0271242 R-DDI-6798749 https://reactome.org/PathwayBrowser/#/R-DDI-6798749 Exocytosis of specific granule lumen proteins IEA Dictyostelium discoideum DDB_G0271242 R-DDI-6798751 https://reactome.org/PathwayBrowser/#/R-DDI-6798751 Exocytosis of azurophil granule lumen proteins IEA Dictyostelium discoideum DDB_G0271242 R-DDI-6807585 https://reactome.org/PathwayBrowser/#/R-DDI-6807585 BPI binds LPS on the bacterial surface IEA Dictyostelium discoideum DDB_G0271242 R-DDI-8869683 https://reactome.org/PathwayBrowser/#/R-DDI-8869683 oxPL binds LBP IEA Dictyostelium discoideum DDB_G0271264 R-DDI-5689539 https://reactome.org/PathwayBrowser/#/R-DDI-5689539 ADRM1:26S proteaseome binds USP14 IEA Dictyostelium discoideum DDB_G0271264 R-DDI-9750942 https://reactome.org/PathwayBrowser/#/R-DDI-9750942 USP14 deubiquitinates NLRC5 IEA Dictyostelium discoideum DDB_G0271282 R-DDI-5691006 https://reactome.org/PathwayBrowser/#/R-DDI-5691006 XPC:RAD23:CETN2 and UV-DDB bind distorted dsDNA site IEA Dictyostelium discoideum DDB_G0271282 R-DDI-6781833 https://reactome.org/PathwayBrowser/#/R-DDI-6781833 ERCC8 (CSA) binds stalled RNA Pol II IEA Dictyostelium discoideum DDB_G0271282 R-DDI-8863721 https://reactome.org/PathwayBrowser/#/R-DDI-8863721 NEDD8-STON binds TOR1 hexamer and COP9 complex IEA Dictyostelium discoideum DDB_G0271282 R-DDI-8863723 https://reactome.org/PathwayBrowser/#/R-DDI-8863723 COP9 and TOR1 deneddylate STON2 IEA Dictyostelium discoideum DDB_G0271282 R-DDI-8956040 https://reactome.org/PathwayBrowser/#/R-DDI-8956040 COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes IEA Dictyostelium discoideum DDB_G0271282 R-DDI-8956045 https://reactome.org/PathwayBrowser/#/R-DDI-8956045 COP9 signalosome deneddylates nuclear CRL4 E3 ubiquitin ligase complex IEA Dictyostelium discoideum DDB_G0271288 R-DDI-9639287 https://reactome.org/PathwayBrowser/#/R-DDI-9639287 SESN1,2 binds L-leucine and dissociates from GATOR2 IEA Dictyostelium discoideum DDB_G0271288 R-DDI-9640195 https://reactome.org/PathwayBrowser/#/R-DDI-9640195 RRAGA,B hydrolyzes GTP IEA Dictyostelium discoideum DDB_G0271298 R-DDI-156826 https://reactome.org/PathwayBrowser/#/R-DDI-156826 Dissociation of L13a from the 60s ribosomal subunit IEA Dictyostelium discoideum DDB_G0271298 R-DDI-1799332 https://reactome.org/PathwayBrowser/#/R-DDI-1799332 Nascent polypeptide:mRNA:ribosome complex binds signal recognition particle (SRP) IEA Dictyostelium discoideum DDB_G0271298 R-DDI-72671 https://reactome.org/PathwayBrowser/#/R-DDI-72671 eIF5B:GTP is hydrolyzed and released IEA Dictyostelium discoideum DDB_G0271298 R-DDI-72672 https://reactome.org/PathwayBrowser/#/R-DDI-72672 The 60S subunit joins the translation initiation complex IEA Dictyostelium discoideum DDB_G0271298 R-DDI-72673 https://reactome.org/PathwayBrowser/#/R-DDI-72673 Release of 40S and 60S subunits from the 80S ribosome IEA Dictyostelium discoideum DDB_G0271298 R-DDI-927789 https://reactome.org/PathwayBrowser/#/R-DDI-927789 Formation of UPF1:eRF3 complex on mRNA with a premature termination codon and no Exon Junction Complex IEA Dictyostelium discoideum DDB_G0271298 R-DDI-927832 https://reactome.org/PathwayBrowser/#/R-DDI-927832 UPF1 binds an mRNP with a termination codon preceding an Exon Junction Complex IEA Dictyostelium discoideum DDB_G0271298 R-DDI-927889 https://reactome.org/PathwayBrowser/#/R-DDI-927889 SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex) IEA Dictyostelium discoideum DDB_G0271338 R-DDI-109636 https://reactome.org/PathwayBrowser/#/R-DDI-109636 Recognition and Binding of Core Promoter Elements by TFIID IEA Dictyostelium discoideum DDB_G0271338 R-DDI-109637 https://reactome.org/PathwayBrowser/#/R-DDI-109637 Binding of TFIIA and TFIIB to the pol II promoter:TFIID complex IEA Dictyostelium discoideum DDB_G0271338 R-DDI-109638 https://reactome.org/PathwayBrowser/#/R-DDI-109638 Recruitment of RNA Polymerase II Holoenzyme by TFIIF to the pol II promoter:TFIID:TFIIA:TFIIB complex IEA Dictyostelium discoideum DDB_G0271338 R-DDI-109639 https://reactome.org/PathwayBrowser/#/R-DDI-109639 Formation of the closed pre-initiation complex IEA Dictyostelium discoideum DDB_G0271338 R-DDI-73946 https://reactome.org/PathwayBrowser/#/R-DDI-73946 Abortive initiation after formation of the first phosphodiester bond IEA Dictyostelium discoideum DDB_G0271338 R-DDI-75095 https://reactome.org/PathwayBrowser/#/R-DDI-75095 Binding of TFIIE to the growing preinitiation complex IEA Dictyostelium discoideum DDB_G0271338 R-DDI-75850 https://reactome.org/PathwayBrowser/#/R-DDI-75850 Addition of the third nucleotide on the nascent transcript IEA Dictyostelium discoideum DDB_G0271338 R-DDI-75856 https://reactome.org/PathwayBrowser/#/R-DDI-75856 Abortive Initiation Before Second Transition IEA Dictyostelium discoideum DDB_G0271338 R-DDI-75861 https://reactome.org/PathwayBrowser/#/R-DDI-75861 NTP Binds Active Site of RNA Polymerase II IEA Dictyostelium discoideum DDB_G0271338 R-DDI-75862 https://reactome.org/PathwayBrowser/#/R-DDI-75862 Fall Back to Closed Pre-initiation Complex IEA Dictyostelium discoideum DDB_G0271338 R-DDI-75864 https://reactome.org/PathwayBrowser/#/R-DDI-75864 Newly Formed Phosphodiester Bond Stabilized and PPi Released IEA Dictyostelium discoideum DDB_G0271338 R-DDI-75866 https://reactome.org/PathwayBrowser/#/R-DDI-75866 Nucleophillic Attack by 3'-hydroxyl Oxygen of nascent transcript on the Alpha Phosphate of NTP IEA Dictyostelium discoideum DDB_G0271338 R-DDI-75869 https://reactome.org/PathwayBrowser/#/R-DDI-75869 Addition of the fourth nucleotide on the Nascent Transcript: Second Transition IEA Dictyostelium discoideum DDB_G0271338 R-DDI-75873 https://reactome.org/PathwayBrowser/#/R-DDI-75873 Addition of Nucleotides 5 through 9 on the growing Transcript IEA Dictyostelium discoideum DDB_G0271338 R-DDI-75949 https://reactome.org/PathwayBrowser/#/R-DDI-75949 RNA Polymerase II Promoter Opening: First Transition IEA Dictyostelium discoideum DDB_G0271338 R-DDI-9613494 https://reactome.org/PathwayBrowser/#/R-DDI-9613494 Unwinding of DNA for the Nascent Transcript: Second Transition IEA Dictyostelium discoideum DDB_G0271338 R-DDI-9613497 https://reactome.org/PathwayBrowser/#/R-DDI-9613497 Unwinding DNA for the nascent transcript IEA Dictyostelium discoideum DDB_G0271342 R-DDI-1482889 https://reactome.org/PathwayBrowser/#/R-DDI-1482889 DAG is acylated to TAG by DGAT1/2 IEA Dictyostelium discoideum DDB_G0271342 R-DDI-6799350 https://reactome.org/PathwayBrowser/#/R-DDI-6799350 Exocytosis of specific granule membrane proteins IEA Dictyostelium discoideum DDB_G0271342 R-DDI-75900 https://reactome.org/PathwayBrowser/#/R-DDI-75900 1,2-diacyl-glycerol + acyl-CoA => triacylglycerol + CoASH [DGAT1] IEA Dictyostelium discoideum DDB_G0271344 R-DDI-70967 https://reactome.org/PathwayBrowser/#/R-DDI-70967 IDH3 complex decarboxylates isocitrate IEA Dictyostelium discoideum DDB_G0271346 R-DDI-6781953 https://reactome.org/PathwayBrowser/#/R-DDI-6781953 YOD1 binds VCP IEA Dictyostelium discoideum DDB_G0271350 R-DDI-203797 https://reactome.org/PathwayBrowser/#/R-DDI-203797 ERKs are inactivated by dual-specific phosphatases (DUSPs) IEA Dictyostelium discoideum DDB_G0271350 R-DDI-5675373 https://reactome.org/PathwayBrowser/#/R-DDI-5675373 Nuclear DUSPs dephosphorylate MAPKs IEA Dictyostelium discoideum DDB_G0271350 R-DDI-5675376 https://reactome.org/PathwayBrowser/#/R-DDI-5675376 Cytosolic DUSPs dephosphorylate MAPKs IEA Dictyostelium discoideum DDB_G0271356 R-DDI-430311 https://reactome.org/PathwayBrowser/#/R-DDI-430311 Rsu-1 interacts with Pinch1 IEA Dictyostelium discoideum DDB_G0271372 R-DDI-1504190 https://reactome.org/PathwayBrowser/#/R-DDI-1504190 DVL is ubiquitinated by CUL3:KLHL12:RBX1 IEA Dictyostelium discoideum DDB_G0271372 R-DDI-1504193 https://reactome.org/PathwayBrowser/#/R-DDI-1504193 Ubiquitinated DVL is degraded by the proteasome IEA Dictyostelium discoideum DDB_G0271372 R-DDI-5658424 https://reactome.org/PathwayBrowser/#/R-DDI-5658424 KBTBD7:CUL3:RBX1 ubiquitinates NF1 IEA Dictyostelium discoideum DDB_G0271372 R-DDI-8952630 https://reactome.org/PathwayBrowser/#/R-DDI-8952630 NEDD8:AcM-UBE2M binds CRL3 E3 ubiquitin ligase complex IEA Dictyostelium discoideum DDB_G0271372 R-DDI-8952631 https://reactome.org/PathwayBrowser/#/R-DDI-8952631 AcM-UBE2M transfers NEDD8 to CRL3 E3 ubiquitin ligase complex IEA Dictyostelium discoideum DDB_G0271372 R-DDI-8955241 https://reactome.org/PathwayBrowser/#/R-DDI-8955241 CAND1 binds cytosolic CRL E3 ubiquitin ligases IEA Dictyostelium discoideum DDB_G0271372 R-DDI-8955289 https://reactome.org/PathwayBrowser/#/R-DDI-8955289 COMMDs displace CAND1 from cytosolic CRL E3 ubiquitin ligase complexes IEA Dictyostelium discoideum DDB_G0271372 R-DDI-8956040 https://reactome.org/PathwayBrowser/#/R-DDI-8956040 COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes IEA Dictyostelium discoideum DDB_G0271372 R-DDI-9712274 https://reactome.org/PathwayBrowser/#/R-DDI-9712274 NFE2L2 inducers bind to KEAP1:CUL3:RBX1:NFE2L2 IEA Dictyostelium discoideum DDB_G0271372 R-DDI-9755505 https://reactome.org/PathwayBrowser/#/R-DDI-9755505 KEAP1:NEDD8-CUL3:RBX1 complex ubiquitinates NFE2L2 IEA Dictyostelium discoideum DDB_G0271372 R-DDI-9755507 https://reactome.org/PathwayBrowser/#/R-DDI-9755507 UBXN7:UBF1:NPLOC4:VCP hexamer binds NFE2L2:CRL3 complex IEA Dictyostelium discoideum DDB_G0271372 R-DDI-9759169 https://reactome.org/PathwayBrowser/#/R-DDI-9759169 p-S349 SQSTM1 oligomer binds KEAP1:CUL3:RBX1 IEA Dictyostelium discoideum DDB_G0271372 R-DDI-9759172 https://reactome.org/PathwayBrowser/#/R-DDI-9759172 KEAP1:CUL3:RBX1 ubiquitinates p-S349 SQSTM1 oligomer IEA Dictyostelium discoideum DDB_G0271372 R-DDI-9766645 https://reactome.org/PathwayBrowser/#/R-DDI-9766645 CUL3:RBX1 ubiquitinates KEAP1 IEA Dictyostelium discoideum DDB_G0271372 R-DDI-9766656 https://reactome.org/PathwayBrowser/#/R-DDI-9766656 RBX1:CUL3 dissociates from forming autophagosome IEA Dictyostelium discoideum DDB_G0271372 R-DDI-9766677 https://reactome.org/PathwayBrowser/#/R-DDI-9766677 MAP1LC3B binds KEAP1 and SQSTM1 IEA Dictyostelium discoideum DDB_G0271372 R-DDI-9766687 https://reactome.org/PathwayBrowser/#/R-DDI-9766687 SESN1,SESN1 bind SQSTM1 and KEAP1 IEA Dictyostelium discoideum DDB_G0271372 R-DDI-983140 https://reactome.org/PathwayBrowser/#/R-DDI-983140 Transfer of Ub from E2 to substrate and release of E2 IEA Dictyostelium discoideum DDB_G0271372 R-DDI-983147 https://reactome.org/PathwayBrowser/#/R-DDI-983147 Release of E3 from polyubiquitinated substrate IEA Dictyostelium discoideum DDB_G0271372 R-DDI-983156 https://reactome.org/PathwayBrowser/#/R-DDI-983156 Polyubiquitination of substrate IEA Dictyostelium discoideum DDB_G0271372 R-DDI-983157 https://reactome.org/PathwayBrowser/#/R-DDI-983157 Interaction of E3 with substrate and E2-Ub complex IEA Dictyostelium discoideum DDB_G0271388 R-DDI-6809011 https://reactome.org/PathwayBrowser/#/R-DDI-6809011 cis-Golgi t-SNAREs bind YKT6 on tethered vesicle IEA Dictyostelium discoideum DDB_G0271388 R-DDI-6811433 https://reactome.org/PathwayBrowser/#/R-DDI-6811433 The COG tethering complex interacts with numerous SNAREs at the Golgi membrane IEA Dictyostelium discoideum DDB_G0271388 R-DDI-8849748 https://reactome.org/PathwayBrowser/#/R-DDI-8849748 The COG complex binds RABs at the Golgi membrane IEA Dictyostelium discoideum DDB_G0271396 R-DDI-430028 https://reactome.org/PathwayBrowser/#/R-DDI-430028 Exosome Complex hydrolyzes mRNA by 3' to 5' exoribonuclease digestion IEA Dictyostelium discoideum DDB_G0271396 R-DDI-450431 https://reactome.org/PathwayBrowser/#/R-DDI-450431 ZFP36 (TTP) recruits RNA degradation activities IEA Dictyostelium discoideum DDB_G0271396 R-DDI-450488 https://reactome.org/PathwayBrowser/#/R-DDI-450488 BRF1 Complex recruits RNA degradation activities IEA Dictyostelium discoideum DDB_G0271396 R-DDI-6791222 https://reactome.org/PathwayBrowser/#/R-DDI-6791222 21S pre-rRNA is nucleolytically processed at site E (site2a) to yield 18SE pre-rRNA IEA Dictyostelium discoideum DDB_G0271402 R-DDI-2029460 https://reactome.org/PathwayBrowser/#/R-DDI-2029460 PAK1 phosphorylates LIMK1 IEA Dictyostelium discoideum DDB_G0271402 R-DDI-419644 https://reactome.org/PathwayBrowser/#/R-DDI-419644 Transphosphorylation of pLIMK1 IEA Dictyostelium discoideum DDB_G0271402 R-DDI-419645 https://reactome.org/PathwayBrowser/#/R-DDI-419645 Dimerization of LIMK1 by Hsp90 IEA Dictyostelium discoideum DDB_G0271488 R-DDI-917693 https://reactome.org/PathwayBrowser/#/R-DDI-917693 ESCRT Disassembly IEA Dictyostelium discoideum DDB_G0271490 R-DDI-1605736 https://reactome.org/PathwayBrowser/#/R-DDI-1605736 GLA hydrolyzes PSAP(195-273):Gb3Cer:PE IEA Dictyostelium discoideum DDB_G0271490 R-DDI-6798751 https://reactome.org/PathwayBrowser/#/R-DDI-6798751 Exocytosis of azurophil granule lumen proteins IEA Dictyostelium discoideum DDB_G0271490 R-DDI-9841189 https://reactome.org/PathwayBrowser/#/R-DDI-9841189 GLA hydrolyzes PSAP(195-273):Gal2Cer:PE IEA Dictyostelium discoideum DDB_G0271506 R-DDI-8986181 https://reactome.org/PathwayBrowser/#/R-DDI-8986181 PITRM1 proteolyzes mitochondrial targeting peptides (presequences) IEA Dictyostelium discoideum DDB_G0271514 R-DDI-76056 https://reactome.org/PathwayBrowser/#/R-DDI-76056 Recruitment of RNA polymerase III to TFIIIB:TFIIIC:TFIIIA:Type 1 Promoter Complex IEA Dictyostelium discoideum DDB_G0271514 R-DDI-83805 https://reactome.org/PathwayBrowser/#/R-DDI-83805 Recruitment of RNA Polymerase III to the TFIIIB:TFIIIC: Type 2 Promoter Complex IEA Dictyostelium discoideum DDB_G0271516 R-DDI-2029468 https://reactome.org/PathwayBrowser/#/R-DDI-2029468 Conversion of PA into DAG by PAP-1 IEA Dictyostelium discoideum DDB_G0271516 R-DDI-428690 https://reactome.org/PathwayBrowser/#/R-DDI-428690 PLPP1 dephosphorylates extracellular sphingosine-1-phosphate IEA Dictyostelium discoideum DDB_G0271516 R-DDI-428696 https://reactome.org/PathwayBrowser/#/R-DDI-428696 PLPP1,2,3 dephosphorylate cytosolic sphingosine-1-phosphate IEA Dictyostelium discoideum DDB_G0271516 R-DDI-6797630 https://reactome.org/PathwayBrowser/#/R-DDI-6797630 LRPP4(LRPP1-3,5) hydrolyse LPA IEA Dictyostelium discoideum DDB_G0271544 R-DDI-70844 https://reactome.org/PathwayBrowser/#/R-DDI-70844 alpha-methyl-acetoacetyl-CoA + CoA => propionyl-CoA + acetyl-CoA IEA Dictyostelium discoideum DDB_G0271544 R-DDI-73916 https://reactome.org/PathwayBrowser/#/R-DDI-73916 2 acetyl-CoA <=> acetoacetyl-CoA + CoA IEA Dictyostelium discoideum DDB_G0271544 R-DDI-74181 https://reactome.org/PathwayBrowser/#/R-DDI-74181 acetoacetyl-CoA + CoA <=> 2 acetyl-CoA IEA Dictyostelium discoideum DDB_G0271544 R-DDI-8848215 https://reactome.org/PathwayBrowser/#/R-DDI-8848215 ACAT2 condenses 2 Ac-CoA to form ACA-CoA IEA Dictyostelium discoideum DDB_G0271544 R-DDI-9838081 https://reactome.org/PathwayBrowser/#/R-DDI-9838081 LONP1 degrades mitochondrial matrix proteins IEA Dictyostelium discoideum DDB_G0271544 R-DDI-9838093 https://reactome.org/PathwayBrowser/#/R-DDI-9838093 LONP1 binds mitochondrial matrix proteins IEA Dictyostelium discoideum DDB_G0271562 R-DDI-68610 https://reactome.org/PathwayBrowser/#/R-DDI-68610 Formation of ORC(2-5) complex IEA Dictyostelium discoideum DDB_G0271562 R-DDI-68611 https://reactome.org/PathwayBrowser/#/R-DDI-68611 Formation of ORC(1-5) complex IEA Dictyostelium discoideum DDB_G0271562 R-DDI-68615 https://reactome.org/PathwayBrowser/#/R-DDI-68615 Formation of ORC(1-6) complex IEA Dictyostelium discoideum DDB_G0271562 R-DDI-68688 https://reactome.org/PathwayBrowser/#/R-DDI-68688 CDC6 association with ORC(1-6) at replication origins IEA Dictyostelium discoideum DDB_G0271562 R-DDI-68914 https://reactome.org/PathwayBrowser/#/R-DDI-68914 DNA polymerase alpha:primase binds at the origin IEA Dictyostelium discoideum DDB_G0271562 R-DDI-68917 https://reactome.org/PathwayBrowser/#/R-DDI-68917 Cdc45 associates with the pre-replicative complex at the origin IEA Dictyostelium discoideum DDB_G0271562 R-DDI-68960 https://reactome.org/PathwayBrowser/#/R-DDI-68960 DNA polymerase epsilon binds at the origin IEA Dictyostelium discoideum DDB_G0271564 R-DDI-9861616 https://reactome.org/PathwayBrowser/#/R-DDI-9861616 DLD dimer dehydrogenates dihydrolipoyl IEA Dictyostelium discoideum DDB_G0271564 R-DDI-9861667 https://reactome.org/PathwayBrowser/#/R-DDI-9861667 DLAT trimer transfers acetyl to CoA IEA Dictyostelium discoideum DDB_G0271564 R-DDI-9861734 https://reactome.org/PathwayBrowser/#/R-DDI-9861734 PDH E1 decarboxylates PYR, transferring acetyl to DLAT IEA Dictyostelium discoideum DDB_G0271572 R-DDI-6791222 https://reactome.org/PathwayBrowser/#/R-DDI-6791222 21S pre-rRNA is nucleolytically processed at site E (site2a) to yield 18SE pre-rRNA IEA Dictyostelium discoideum DDB_G0271608 R-DDI-110322 https://reactome.org/PathwayBrowser/#/R-DDI-110322 Formation of Pol zeta complex IEA Dictyostelium discoideum DDB_G0271608 R-DDI-5655892 https://reactome.org/PathwayBrowser/#/R-DDI-5655892 POLK incorporates dNMP opposite to damaged DNA base IEA Dictyostelium discoideum DDB_G0271610 R-DDI-1675795 https://reactome.org/PathwayBrowser/#/R-DDI-1675795 PI3P is dephosphorylated to PI by MTM proteins at the late endosome membrane IEA Dictyostelium discoideum DDB_G0271610 R-DDI-1675994 https://reactome.org/PathwayBrowser/#/R-DDI-1675994 PI3P is dephosphorylated to PI by SYNJ/MTMs at the plasma membrane IEA Dictyostelium discoideum DDB_G0271610 R-DDI-1676065 https://reactome.org/PathwayBrowser/#/R-DDI-1676065 PI(3,5)P2 is dephosphorylated to PI5P by MTM proteins at the late endosome membrane IEA Dictyostelium discoideum DDB_G0271610 R-DDI-1676105 https://reactome.org/PathwayBrowser/#/R-DDI-1676105 PI(3,5)P2 is dephosphorylated to PI5P by MTM proteins at the early endosome membrane IEA Dictyostelium discoideum DDB_G0271610 R-DDI-1676141 https://reactome.org/PathwayBrowser/#/R-DDI-1676141 PI3P is dephosphorylated to PI by MTM proteins at the early endosome membrane IEA Dictyostelium discoideum DDB_G0271610 R-DDI-1676203 https://reactome.org/PathwayBrowser/#/R-DDI-1676203 PI(3,5)P2 is dephosphorylated to PI5P by SYNJ/MTMs at the plasma membrane IEA Dictyostelium discoideum DDB_G0271610 R-DDI-5679206 https://reactome.org/PathwayBrowser/#/R-DDI-5679206 MTMR14, MTMR3 dephosphorylate PI3P IEA Dictyostelium discoideum DDB_G0271610 R-DDI-6809254 https://reactome.org/PathwayBrowser/#/R-DDI-6809254 MTMR8 binds MTMR9 IEA Dictyostelium discoideum DDB_G0271610 R-DDI-6809309 https://reactome.org/PathwayBrowser/#/R-DDI-6809309 MTMR6 binds MTMR9 IEA Dictyostelium discoideum DDB_G0271610 R-DDI-6809320 https://reactome.org/PathwayBrowser/#/R-DDI-6809320 PI(3,5)P2 is dephosphorylated to PI5P by MTMR9-bound MTMR6 or MTMR8 at the plasma membrane IEA Dictyostelium discoideum DDB_G0271610 R-DDI-6809325 https://reactome.org/PathwayBrowser/#/R-DDI-6809325 PI3P is dephosphorylated to PI by MTMR9-bound MTMR8 or MTMR6 at the plasma membrane IEA Dictyostelium discoideum DDB_G0271610 R-DDI-6809680 https://reactome.org/PathwayBrowser/#/R-DDI-6809680 MTMR12 binds MTM1 IEA Dictyostelium discoideum DDB_G0271610 R-DDI-6809707 https://reactome.org/PathwayBrowser/#/R-DDI-6809707 MTMR12 binds MTMR2 IEA Dictyostelium discoideum DDB_G0271610 R-DDI-6809720 https://reactome.org/PathwayBrowser/#/R-DDI-6809720 PI3P is dephosphorylated to PI by MTM1:MTMR12 IEA Dictyostelium discoideum DDB_G0271610 R-DDI-6809764 https://reactome.org/PathwayBrowser/#/R-DDI-6809764 SBF1 binds MTMR2 IEA Dictyostelium discoideum DDB_G0271610 R-DDI-6809777 https://reactome.org/PathwayBrowser/#/R-DDI-6809777 PI3P is dephosphorylated to PI by MTMR2:SBF1 IEA Dictyostelium discoideum DDB_G0271610 R-DDI-6809778 https://reactome.org/PathwayBrowser/#/R-DDI-6809778 PI(3,5)P2 is dephosphorylated to PI5P by MTMR2:SBF1 IEA Dictyostelium discoideum DDB_G0271610 R-DDI-8876837 https://reactome.org/PathwayBrowser/#/R-DDI-8876837 RAB21 GEFs exchange GTP for GDP on RAB21 IEA Dictyostelium discoideum DDB_G0271626 R-DDI-5649764 https://reactome.org/PathwayBrowser/#/R-DDI-5649764 DOT1L (KMT4) methylates methyl-lysine-80 of histone H3 (H3K79) IEA Dictyostelium discoideum DDB_G0271626 R-DDI-5649799 https://reactome.org/PathwayBrowser/#/R-DDI-5649799 DOT1L (KMT4) methylates dimethyl-lysine-80 of histone H3 (H3K79) IEA Dictyostelium discoideum DDB_G0271626 R-DDI-5649801 https://reactome.org/PathwayBrowser/#/R-DDI-5649801 DOT1L (KMT4) methylates lysine-80 of histone H3 (H3K79) IEA Dictyostelium discoideum DDB_G0271630 R-DDI-1676114 https://reactome.org/PathwayBrowser/#/R-DDI-1676114 PI3P is dephosphorylated to PI by SACM1L at the Golgi membrane IEA Dictyostelium discoideum DDB_G0271630 R-DDI-1676124 https://reactome.org/PathwayBrowser/#/R-DDI-1676124 PI4P is dephosphorylated to PI by SACM1L at the ER membrane IEA Dictyostelium discoideum DDB_G0271630 R-DDI-1676133 https://reactome.org/PathwayBrowser/#/R-DDI-1676133 PI4P is dephosphorylated to PI by SACM1L at the Golgi membrane IEA Dictyostelium discoideum DDB_G0271630 R-DDI-8849969 https://reactome.org/PathwayBrowser/#/R-DDI-8849969 PI(4,5)P2, PI(3,4)P2 and PI(3,4,5)P3 are dephosphorylated to PI5P, PI3P and PI(3,4)P by INPP5F at the endosome membrane IEA Dictyostelium discoideum DDB_G0271642 R-DDI-1363328 https://reactome.org/PathwayBrowser/#/R-DDI-1363328 Phosphorylated p130 (RBL2) binds SCF(Skp2):Cks1 complex IEA Dictyostelium discoideum DDB_G0271642 R-DDI-1363331 https://reactome.org/PathwayBrowser/#/R-DDI-1363331 Ubiquitination of p130 (RBL2) by SCF (Skp2) IEA Dictyostelium discoideum DDB_G0271660 R-DDI-139970 https://reactome.org/PathwayBrowser/#/R-DDI-139970 FMO3:FAD N-oxidises TMA to TMAO IEA Dictyostelium discoideum DDB_G0271660 R-DDI-1655453 https://reactome.org/PathwayBrowser/#/R-DDI-1655453 FMO1:FAD oxidizes HTAU to TAU IEA Dictyostelium discoideum DDB_G0271660 R-DDI-217255 https://reactome.org/PathwayBrowser/#/R-DDI-217255 FMO1:FAD N-oxidises TAM IEA Dictyostelium discoideum DDB_G0271660 R-DDI-217258 https://reactome.org/PathwayBrowser/#/R-DDI-217258 FMO2:FAD:Mg2+ S-oxidises MTZ IEA Dictyostelium discoideum DDB_G0271668 R-DDI-156826 https://reactome.org/PathwayBrowser/#/R-DDI-156826 Dissociation of L13a from the 60s ribosomal subunit IEA Dictyostelium discoideum DDB_G0271668 R-DDI-1799332 https://reactome.org/PathwayBrowser/#/R-DDI-1799332 Nascent polypeptide:mRNA:ribosome complex binds signal recognition particle (SRP) IEA Dictyostelium discoideum DDB_G0271668 R-DDI-72671 https://reactome.org/PathwayBrowser/#/R-DDI-72671 eIF5B:GTP is hydrolyzed and released IEA Dictyostelium discoideum DDB_G0271668 R-DDI-72672 https://reactome.org/PathwayBrowser/#/R-DDI-72672 The 60S subunit joins the translation initiation complex IEA Dictyostelium discoideum DDB_G0271668 R-DDI-72673 https://reactome.org/PathwayBrowser/#/R-DDI-72673 Release of 40S and 60S subunits from the 80S ribosome IEA Dictyostelium discoideum DDB_G0271668 R-DDI-927789 https://reactome.org/PathwayBrowser/#/R-DDI-927789 Formation of UPF1:eRF3 complex on mRNA with a premature termination codon and no Exon Junction Complex IEA Dictyostelium discoideum DDB_G0271668 R-DDI-927832 https://reactome.org/PathwayBrowser/#/R-DDI-927832 UPF1 binds an mRNP with a termination codon preceding an Exon Junction Complex IEA Dictyostelium discoideum DDB_G0271668 R-DDI-927889 https://reactome.org/PathwayBrowser/#/R-DDI-927889 SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex) IEA Dictyostelium discoideum DDB_G0271676 R-DDI-8856813 https://reactome.org/PathwayBrowser/#/R-DDI-8856813 AAK1 phosphorylates AP-2 mu subunit at T156 IEA Dictyostelium discoideum DDB_G0271676 R-DDI-8868072 https://reactome.org/PathwayBrowser/#/R-DDI-8868072 Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2 IEA Dictyostelium discoideum DDB_G0271690 R-DDI-112383 https://reactome.org/PathwayBrowser/#/R-DDI-112383 Hypophosphorylation of RNA Pol II CTD by FCP1P protein IEA Dictyostelium discoideum DDB_G0271690 R-DDI-113407 https://reactome.org/PathwayBrowser/#/R-DDI-113407 DSIF complex binds to RNA Pol II (hypophosphorylated) IEA Dictyostelium discoideum DDB_G0271690 R-DDI-113409 https://reactome.org/PathwayBrowser/#/R-DDI-113409 Abortive termination of early transcription elongation by DSIF:NELF IEA Dictyostelium discoideum DDB_G0271690 R-DDI-6797606 https://reactome.org/PathwayBrowser/#/R-DDI-6797606 CDK12 phosphorylates RNA Pol II CTD at DNA repair genes IEA Dictyostelium discoideum DDB_G0271690 R-DDI-6797616 https://reactome.org/PathwayBrowser/#/R-DDI-6797616 CCNK:CDK12 binds RNA Pol II at DNA repair genes IEA Dictyostelium discoideum DDB_G0271720 R-DDI-804969 https://reactome.org/PathwayBrowser/#/R-DDI-804969 HSD17B1 hydrogenates E1 to EST17b IEA Dictyostelium discoideum DDB_G0271726 R-DDI-8852129 https://reactome.org/PathwayBrowser/#/R-DDI-8852129 UBA1 conjugates ubiquitin to cytosolic E2 enzymes IEA Dictyostelium discoideum DDB_G0271726 R-DDI-8852130 https://reactome.org/PathwayBrowser/#/R-DDI-8852130 UBA1 conjugates ubiquitin to nuclear E2 enzymes IEA Dictyostelium discoideum DDB_G0271726 R-DDI-983140 https://reactome.org/PathwayBrowser/#/R-DDI-983140 Transfer of Ub from E2 to substrate and release of E2 IEA Dictyostelium discoideum DDB_G0271726 R-DDI-983152 https://reactome.org/PathwayBrowser/#/R-DDI-983152 Transfer of ubiquitin from E1 to E2 IEA Dictyostelium discoideum DDB_G0271726 R-DDI-983156 https://reactome.org/PathwayBrowser/#/R-DDI-983156 Polyubiquitination of substrate IEA Dictyostelium discoideum DDB_G0271726 R-DDI-983157 https://reactome.org/PathwayBrowser/#/R-DDI-983157 Interaction of E3 with substrate and E2-Ub complex IEA Dictyostelium discoideum DDB_G0271728 R-DDI-9770236 https://reactome.org/PathwayBrowser/#/R-DDI-9770236 Formation of the Spliceosomal P complex and exon ligation IEA Dictyostelium discoideum DDB_G0271730 R-DDI-1483203 https://reactome.org/PathwayBrowser/#/R-DDI-1483203 PA is dephosphorylated to DAG by LPIN IEA Dictyostelium discoideum DDB_G0271730 R-DDI-5221130 https://reactome.org/PathwayBrowser/#/R-DDI-5221130 LPIN catalyzes conversion of phosphatidic acid to diacylglycerol IEA Dictyostelium discoideum DDB_G0271730 R-DDI-75899 https://reactome.org/PathwayBrowser/#/R-DDI-75899 1,2-diacyl-glycerol 3-phosphate + H2O => 1,2-diacyl-glycerol + orthophosphate IEA Dictyostelium discoideum DDB_G0271734 R-DDI-392513 https://reactome.org/PathwayBrowser/#/R-DDI-392513 Rap1 signal termination by Rap1GAPs IEA Dictyostelium discoideum DDB_G0271750 R-DDI-5658424 https://reactome.org/PathwayBrowser/#/R-DDI-5658424 KBTBD7:CUL3:RBX1 ubiquitinates NF1 IEA Dictyostelium discoideum DDB_G0271750 R-DDI-5658430 https://reactome.org/PathwayBrowser/#/R-DDI-5658430 NF1 is degraded by the proteasome IEA Dictyostelium discoideum DDB_G0271750 R-DDI-5658438 https://reactome.org/PathwayBrowser/#/R-DDI-5658438 SPRED dimer binds NF1 IEA Dictyostelium discoideum DDB_G0271754 R-DDI-5159245 https://reactome.org/PathwayBrowser/#/R-DDI-5159245 SETD3, SETD7 (KMT7), WHSC1L1 (KMT3F), Core MLL complex methylate lysine-5 of histone H3 (H3K4) IEA Dictyostelium discoideum DDB_G0271754 R-DDI-5244692 https://reactome.org/PathwayBrowser/#/R-DDI-5244692 Core MLL complex, SMYD3, PRDM9 methylate dimethyl-lysine-5 of histone H3 (H3K4) IEA Dictyostelium discoideum DDB_G0271754 R-DDI-5637686 https://reactome.org/PathwayBrowser/#/R-DDI-5637686 WHSC1L1 (KMT3F), Core MLL complex, SMYD3 (KMT3E) methylate methyl-lysine-5 of histone H3 (H3K4) IEA Dictyostelium discoideum DDB_G0271754 R-DDI-9675215 https://reactome.org/PathwayBrowser/#/R-DDI-9675215 Formation of the RBBP5:ASH2L heterodimer IEA Dictyostelium discoideum DDB_G0271754 R-DDI-9676257 https://reactome.org/PathwayBrowser/#/R-DDI-9676257 Formation of the SET1A complex IEA Dictyostelium discoideum DDB_G0271754 R-DDI-9676264 https://reactome.org/PathwayBrowser/#/R-DDI-9676264 Formation of the SET1B complex IEA Dictyostelium discoideum DDB_G0271754 R-DDI-9821475 https://reactome.org/PathwayBrowser/#/R-DDI-9821475 CXXC1 and WDR82 bind SET1A complex IEA Dictyostelium discoideum DDB_G0271754 R-DDI-9821476 https://reactome.org/PathwayBrowser/#/R-DDI-9821476 CXXC1 and WDR82 bind SET1B complex IEA Dictyostelium discoideum DDB_G0271760 R-DDI-1855157 https://reactome.org/PathwayBrowser/#/R-DDI-1855157 1-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by IP6K1/2 in the nucleus IEA Dictyostelium discoideum DDB_G0271760 R-DDI-1855158 https://reactome.org/PathwayBrowser/#/R-DDI-1855158 5-PP-IP5 is phosphorylated to 5-PPP-IP5 by IP6K1/3 in the cytosol IEA Dictyostelium discoideum DDB_G0271760 R-DDI-1855181 https://reactome.org/PathwayBrowser/#/R-DDI-1855181 I(1,3,4,5,6)P5 is phosphorylated to 5-PP-IP4 by IP6K1/2 in the nucleus IEA Dictyostelium discoideum DDB_G0271760 R-DDI-1855193 https://reactome.org/PathwayBrowser/#/R-DDI-1855193 1-PP-IP4 is phosphorylated to 1,5-(PP)2-IP3 by IP6K1/3 in the cytosol IEA Dictyostelium discoideum DDB_G0271760 R-DDI-1855194 https://reactome.org/PathwayBrowser/#/R-DDI-1855194 1-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by IP6K1/3 in the cytosol IEA Dictyostelium discoideum DDB_G0271760 R-DDI-1855207 https://reactome.org/PathwayBrowser/#/R-DDI-1855207 IP6 is phosphorylated to 5-PP-IP5 by IP6K1/2 in the nucleus IEA Dictyostelium discoideum DDB_G0271760 R-DDI-1855223 https://reactome.org/PathwayBrowser/#/R-DDI-1855223 I(1,3,4,5,6)P5 is phosphorylated to 5-PP-IP4 by IP6K1/3 in the cytosol IEA Dictyostelium discoideum DDB_G0271760 R-DDI-1855224 https://reactome.org/PathwayBrowser/#/R-DDI-1855224 5-PP-IP5 is phosphorylated to 5-PPP-IP5 by IP6K1/2 in the nucleus IEA Dictyostelium discoideum DDB_G0271760 R-DDI-1855227 https://reactome.org/PathwayBrowser/#/R-DDI-1855227 IP6 is phosphorylated to 5-PP-IP5 by IP6K1/3 in the cytosol IEA Dictyostelium discoideum DDB_G0271760 R-DDI-1855230 https://reactome.org/PathwayBrowser/#/R-DDI-1855230 5-PP-IP4 is phosphorylated to 1,5-(PP)2-IP3 by IP6K1/2 in the nucleus IEA Dictyostelium discoideum DDB_G0271774 R-DDI-164651 https://reactome.org/PathwayBrowser/#/R-DDI-164651 Electron transfer from ubiquinol to cytochrome c of complex III IEA Dictyostelium discoideum DDB_G0271778 R-DDI-143468 https://reactome.org/PathwayBrowser/#/R-DDI-143468 MEOS oxidizes ethanol to acetaldehyde IEA Dictyostelium discoideum DDB_G0271778 R-DDI-156526 https://reactome.org/PathwayBrowser/#/R-DDI-156526 CYP1A2,3A4,3A5,2A13 oxidise AFB1 to AFXBO IEA Dictyostelium discoideum DDB_G0271778 R-DDI-211874 https://reactome.org/PathwayBrowser/#/R-DDI-211874 CYP2S1 4-hydroxylates atRA IEA Dictyostelium discoideum DDB_G0271778 R-DDI-211881 https://reactome.org/PathwayBrowser/#/R-DDI-211881 Coumarin is 7-hydroxylated by CYP2A13 IEA Dictyostelium discoideum DDB_G0271778 R-DDI-211910 https://reactome.org/PathwayBrowser/#/R-DDI-211910 CYP2C8 inactivates paclitaxel by 6alpha-hydroxylation IEA Dictyostelium discoideum DDB_G0271778 R-DDI-211929 https://reactome.org/PathwayBrowser/#/R-DDI-211929 CYP2C19 5-hydroxylates omeprazole IEA Dictyostelium discoideum DDB_G0271778 R-DDI-211960 https://reactome.org/PathwayBrowser/#/R-DDI-211960 CYP2U1 19-hydroxylates ARA IEA Dictyostelium discoideum DDB_G0271778 R-DDI-211966 https://reactome.org/PathwayBrowser/#/R-DDI-211966 CYP2D6 4-hydroxylates debrisoquine IEA Dictyostelium discoideum DDB_G0271778 R-DDI-211968 https://reactome.org/PathwayBrowser/#/R-DDI-211968 CYP2W1 oxidises INDOL IEA Dictyostelium discoideum DDB_G0271778 R-DDI-211983 https://reactome.org/PathwayBrowser/#/R-DDI-211983 CYP2J2 oxidises ARA IEA Dictyostelium discoideum DDB_G0271778 R-DDI-211988 https://reactome.org/PathwayBrowser/#/R-DDI-211988 CYP2C9 inactivates tolbutamide by 4methyl-hydroxylation IEA Dictyostelium discoideum DDB_G0271778 R-DDI-211991 https://reactome.org/PathwayBrowser/#/R-DDI-211991 Cyclophosphamide is 4-hydroxylated by CYP2B6 IEA Dictyostelium discoideum DDB_G0271778 R-DDI-212004 https://reactome.org/PathwayBrowser/#/R-DDI-212004 CYP2C18 initiates bioactivation of phenytoin by 4-hydroxylation IEA Dictyostelium discoideum DDB_G0271778 R-DDI-212005 https://reactome.org/PathwayBrowser/#/R-DDI-212005 CYP2F1 dehydrogenates 3-methylindole IEA Dictyostelium discoideum DDB_G0271778 R-DDI-2161814 https://reactome.org/PathwayBrowser/#/R-DDI-2161814 Arachidonate is hydroxylated to 19-HETE by CYP(2) IEA Dictyostelium discoideum DDB_G0271778 R-DDI-2161890 https://reactome.org/PathwayBrowser/#/R-DDI-2161890 Arachidonate is epoxidated to 5,6-EET by CYP(4) IEA Dictyostelium discoideum DDB_G0271778 R-DDI-2161899 https://reactome.org/PathwayBrowser/#/R-DDI-2161899 Arachidonate is epoxidated to 8,9-EET by CYP(5) IEA Dictyostelium discoideum DDB_G0271778 R-DDI-2161940 https://reactome.org/PathwayBrowser/#/R-DDI-2161940 Arachidonate is hydroxylated to 20-HETE by CYP(3) IEA Dictyostelium discoideum DDB_G0271778 R-DDI-5423647 https://reactome.org/PathwayBrowser/#/R-DDI-5423647 CYP2A13 oxidises AFM1 to AFM1E IEA Dictyostelium discoideum DDB_G0271778 R-DDI-76354 https://reactome.org/PathwayBrowser/#/R-DDI-76354 Vinyl chloride is oxidized to 2-Chloroethylene oxide IEA Dictyostelium discoideum DDB_G0271778 R-DDI-76397 https://reactome.org/PathwayBrowser/#/R-DDI-76397 Acetaminophen oxidised to N-acetylbenzoquinoneimine (NAPQI) IEA Dictyostelium discoideum DDB_G0271778 R-DDI-76416 https://reactome.org/PathwayBrowser/#/R-DDI-76416 Benzene is hydroxylated to phenol IEA Dictyostelium discoideum DDB_G0271778 R-DDI-76434 https://reactome.org/PathwayBrowser/#/R-DDI-76434 Dehalogenation of carbon tetrachloride to form a free radical IEA Dictyostelium discoideum DDB_G0271778 R-DDI-76453 https://reactome.org/PathwayBrowser/#/R-DDI-76453 Coumarin is 7-hydroxylated by CYP2A6 IEA Dictyostelium discoideum DDB_G0271778 R-DDI-76456 https://reactome.org/PathwayBrowser/#/R-DDI-76456 O-atom dealkylation of dextromethorphan IEA Dictyostelium discoideum DDB_G0271778 R-DDI-76475 https://reactome.org/PathwayBrowser/#/R-DDI-76475 Dehalogenation of the poly-halogenated hydrocarbon Halothane to form the acylhalide Trifluoroacetlychloride and hydrogen bromide IEA Dictyostelium discoideum DDB_G0271778 R-DDI-9027043 https://reactome.org/PathwayBrowser/#/R-DDI-9027043 CYPs hydroxylate DHA to 14(R)-HDHA IEA Dictyostelium discoideum DDB_G0271778 R-DDI-9027302 https://reactome.org/PathwayBrowser/#/R-DDI-9027302 CYP2E1 oxidises 14(S)-HDHA to 14(S),21(R)-diHDHA and 14(S),21(S)-diHDHA IEA Dictyostelium discoideum DDB_G0271778 R-DDI-9027321 https://reactome.org/PathwayBrowser/#/R-DDI-9027321 CYP2E1 oxidises 14(R)-HDHA to 14(R),21(R)-diHDHA and 14(R),21(S)-diHDHA IEA Dictyostelium discoideum DDB_G0271778 R-DDI-9680865 https://reactome.org/PathwayBrowser/#/R-DDI-9680865 CYP3A4, CYP2B6 bind ritonavir IEA Dictyostelium discoideum DDB_G0271778 R-DDI-9749986 https://reactome.org/PathwayBrowser/#/R-DDI-9749986 CYP2,3 cytochromes hydroxylate ST to 2,3-DHBA IEA Dictyostelium discoideum DDB_G0271778 R-DDI-9750016 https://reactome.org/PathwayBrowser/#/R-DDI-9750016 CYP2,3 cytochromes hydroxylate ST to 2,5-DHBA IEA Dictyostelium discoideum DDB_G0271778 R-DDI-9753285 https://reactome.org/PathwayBrowser/#/R-DDI-9753285 CYP2E1 monooxygenates APAP to NAPQI IEA Dictyostelium discoideum DDB_G0271778 R-DDI-9915971 https://reactome.org/PathwayBrowser/#/R-DDI-9915971 Arachidonate is epoxidated to 11,12-EET by CYP(5) IEA Dictyostelium discoideum DDB_G0271778 R-DDI-9915997 https://reactome.org/PathwayBrowser/#/R-DDI-9915997 Arachidonate is epoxidated to 14,15-EET by CYP(5) IEA Dictyostelium discoideum DDB_G0271788 R-DDI-9770236 https://reactome.org/PathwayBrowser/#/R-DDI-9770236 Formation of the Spliceosomal P complex and exon ligation IEA Dictyostelium discoideum DDB_G0271792 R-DDI-1675883 https://reactome.org/PathwayBrowser/#/R-DDI-1675883 PI is phosphorylated to PI4P by PI4KB at the Golgi membrane IEA Dictyostelium discoideum DDB_G0271792 R-DDI-1676152 https://reactome.org/PathwayBrowser/#/R-DDI-1676152 PI4KB binds to ARF1/3:GTP at the Golgi membrane IEA Dictyostelium discoideum DDB_G0271792 R-DDI-350769 https://reactome.org/PathwayBrowser/#/R-DDI-350769 trans-Golgi Network Coat Activation IEA Dictyostelium discoideum DDB_G0271792 R-DDI-5623508 https://reactome.org/PathwayBrowser/#/R-DDI-5623508 GBF1 stimulates nucleotide exchange on ARF4 IEA Dictyostelium discoideum DDB_G0271792 R-DDI-6807866 https://reactome.org/PathwayBrowser/#/R-DDI-6807866 GBF1 recruits ARF:GDP to the ERGIC IEA Dictyostelium discoideum DDB_G0271792 R-DDI-6807868 https://reactome.org/PathwayBrowser/#/R-DDI-6807868 GBF1 stimulates ARF nucleotide exchange IEA Dictyostelium discoideum DDB_G0271792 R-DDI-6807872 https://reactome.org/PathwayBrowser/#/R-DDI-6807872 Active ARF recruits coatomer IEA Dictyostelium discoideum DDB_G0271792 R-DDI-6807875 https://reactome.org/PathwayBrowser/#/R-DDI-6807875 ARFGAP, cargo, v-SNAREs and p24 proteins bind nascent COPI complex IEA Dictyostelium discoideum DDB_G0271792 R-DDI-6807877 https://reactome.org/PathwayBrowser/#/R-DDI-6807877 ARFGAPs stimulate ARF GTPase activity IEA Dictyostelium discoideum DDB_G0271792 R-DDI-6811411 https://reactome.org/PathwayBrowser/#/R-DDI-6811411 GBF1 recruits ARF:GDP to the Golgi IEA Dictyostelium discoideum DDB_G0271792 R-DDI-6811412 https://reactome.org/PathwayBrowser/#/R-DDI-6811412 Active ARF recruits coatomer to the Golgi IEA Dictyostelium discoideum DDB_G0271792 R-DDI-6811414 https://reactome.org/PathwayBrowser/#/R-DDI-6811414 GBF1 stimulates nucleotide exchange on ARF IEA Dictyostelium discoideum DDB_G0271792 R-DDI-6811417 https://reactome.org/PathwayBrowser/#/R-DDI-6811417 ARFGAP, cargo, vSNARES and p24 proteins bind COPI vesicles at Golgi IEA Dictyostelium discoideum DDB_G0271792 R-DDI-6811418 https://reactome.org/PathwayBrowser/#/R-DDI-6811418 ARFGAPs stimulate ARF GTPase activity at the Golgi membrane IEA Dictyostelium discoideum DDB_G0271792 R-DDI-8847880 https://reactome.org/PathwayBrowser/#/R-DDI-8847880 CYTH proteins bind ARF1:GTP IEA Dictyostelium discoideum DDB_G0271792 R-DDI-8847883 https://reactome.org/PathwayBrowser/#/R-DDI-8847883 CYTH proteins stimulate ARF1 GTPase activity IEA Dictyostelium discoideum DDB_G0271794 R-DDI-1482962 https://reactome.org/PathwayBrowser/#/R-DDI-1482962 CDP-ETA and DAG are converted to PE by CEPT1/EPT1 IEA Dictyostelium discoideum DDB_G0271794 R-DDI-1482973 https://reactome.org/PathwayBrowser/#/R-DDI-1482973 CDP-Cho and DAG are converted to PC by CHPT1 at the Golgi membrane IEA Dictyostelium discoideum DDB_G0271798 R-DDI-5690080 https://reactome.org/PathwayBrowser/#/R-DDI-5690080 USP3,SAGA deubiquitinate Histone H2A,H2B IEA Dictyostelium discoideum DDB_G0271806 R-DDI-392513 https://reactome.org/PathwayBrowser/#/R-DDI-392513 Rap1 signal termination by Rap1GAPs IEA Dictyostelium discoideum DDB_G0271812 R-DDI-8856813 https://reactome.org/PathwayBrowser/#/R-DDI-8856813 AAK1 phosphorylates AP-2 mu subunit at T156 IEA Dictyostelium discoideum DDB_G0271812 R-DDI-8868072 https://reactome.org/PathwayBrowser/#/R-DDI-8868072 Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2 IEA Dictyostelium discoideum DDB_G0271820 R-DDI-804969 https://reactome.org/PathwayBrowser/#/R-DDI-804969 HSD17B1 hydrogenates E1 to EST17b IEA Dictyostelium discoideum DDB_G0271830 R-DDI-4419978 https://reactome.org/PathwayBrowser/#/R-DDI-4419978 DHDDS:NUS1 elongates E,E-FPP with (n)IPPP to form pPPP IEA Dictyostelium discoideum DDB_G0271842 R-DDI-70997 https://reactome.org/PathwayBrowser/#/R-DDI-70997 SUCLG1/A2 cleaves succinyl-CoA IEA Dictyostelium discoideum DDB_G0271844 R-DDI-8875320 https://reactome.org/PathwayBrowser/#/R-DDI-8875320 RAB5 GEFs exchange GTP for GDP on RAB5 IEA Dictyostelium discoideum DDB_G0271848 R-DDI-5205649 https://reactome.org/PathwayBrowser/#/R-DDI-5205649 p62 links damaged mitochondria to LC3 IEA Dictyostelium discoideum DDB_G0271848 R-DDI-5205663 https://reactome.org/PathwayBrowser/#/R-DDI-5205663 LC3 binds the autophagosome membrane Atg5-Atg12 complex IEA Dictyostelium discoideum DDB_G0271848 R-DDI-5205673 https://reactome.org/PathwayBrowser/#/R-DDI-5205673 p62 binds ubiquitinated mitochondrial substrates IEA Dictyostelium discoideum DDB_G0271848 R-DDI-9012374 https://reactome.org/PathwayBrowser/#/R-DDI-9012374 VDAC1 transports PYR from cytosol to mitochondrial intermembrane space IEA Dictyostelium discoideum DDB_G0271858 R-DDI-446221 https://reactome.org/PathwayBrowser/#/R-DDI-446221 GMPPB converts Mannose-1-phosphate to GDP-Mannose IEA Dictyostelium discoideum DDB_G0271860 R-DDI-203797 https://reactome.org/PathwayBrowser/#/R-DDI-203797 ERKs are inactivated by dual-specific phosphatases (DUSPs) IEA Dictyostelium discoideum DDB_G0271860 R-DDI-5675373 https://reactome.org/PathwayBrowser/#/R-DDI-5675373 Nuclear DUSPs dephosphorylate MAPKs IEA Dictyostelium discoideum DDB_G0271860 R-DDI-5675376 https://reactome.org/PathwayBrowser/#/R-DDI-5675376 Cytosolic DUSPs dephosphorylate MAPKs IEA Dictyostelium discoideum DDB_G0271862 R-DDI-156823 https://reactome.org/PathwayBrowser/#/R-DDI-156823 Association of phospho-L13a with GAIT element of Ceruloplasmin mRNA IEA Dictyostelium discoideum DDB_G0271862 R-DDI-5227009 https://reactome.org/PathwayBrowser/#/R-DDI-5227009 ABCF1 binds EIF2 IEA Dictyostelium discoideum DDB_G0271862 R-DDI-72621 https://reactome.org/PathwayBrowser/#/R-DDI-72621 Ribosomal scanning IEA Dictyostelium discoideum DDB_G0271862 R-DDI-72663 https://reactome.org/PathwayBrowser/#/R-DDI-72663 De novo formation of eIF2:GTP IEA Dictyostelium discoideum DDB_G0271862 R-DDI-72669 https://reactome.org/PathwayBrowser/#/R-DDI-72669 Met-tRNAi binds to eIF2:GTP to form the ternary complex IEA Dictyostelium discoideum DDB_G0271862 R-DDI-72670 https://reactome.org/PathwayBrowser/#/R-DDI-72670 Formation of eIF2:GDP:eIF2B intermediate IEA Dictyostelium discoideum DDB_G0271862 R-DDI-72691 https://reactome.org/PathwayBrowser/#/R-DDI-72691 Formation of the 43S pre-initiation complex IEA Dictyostelium discoideum DDB_G0271862 R-DDI-72697 https://reactome.org/PathwayBrowser/#/R-DDI-72697 Start codon recognition IEA Dictyostelium discoideum DDB_G0271862 R-DDI-72722 https://reactome.org/PathwayBrowser/#/R-DDI-72722 eIF2 activation IEA Dictyostelium discoideum DDB_G0271862 R-DDI-9840415 https://reactome.org/PathwayBrowser/#/R-DDI-9840415 DELE1(143-515):EIF2AK1 enhances phosphorylation of EIF2S1 (EIF2alpha) IEA Dictyostelium discoideum DDB_G0271868 R-DDI-205039 https://reactome.org/PathwayBrowser/#/R-DDI-205039 p75NTR indirectly activates RAC and Cdc42 via a guanyl-nucleotide exchange factor IEA Dictyostelium discoideum DDB_G0271868 R-DDI-9013143 https://reactome.org/PathwayBrowser/#/R-DDI-9013143 RAC1 GEFs activate RAC1 IEA Dictyostelium discoideum DDB_G0271868 R-DDI-9013159 https://reactome.org/PathwayBrowser/#/R-DDI-9013159 CDC42 GEFs activate CDC42 IEA Dictyostelium discoideum DDB_G0271882 R-DDI-1222516 https://reactome.org/PathwayBrowser/#/R-DDI-1222516 Intraphagosomal pH is lowered to 5 by V-ATPase IEA Dictyostelium discoideum DDB_G0271882 R-DDI-74723 https://reactome.org/PathwayBrowser/#/R-DDI-74723 Endosome acidification IEA Dictyostelium discoideum DDB_G0271882 R-DDI-917841 https://reactome.org/PathwayBrowser/#/R-DDI-917841 Acidification of Tf:TfR1 containing endosome IEA Dictyostelium discoideum DDB_G0271882 R-DDI-9639286 https://reactome.org/PathwayBrowser/#/R-DDI-9639286 RRAGC,D exchanges GTP for GDP IEA Dictyostelium discoideum DDB_G0271882 R-DDI-9640167 https://reactome.org/PathwayBrowser/#/R-DDI-9640167 RRAGA,B exchanges GDP for GTP IEA Dictyostelium discoideum DDB_G0271882 R-DDI-9640195 https://reactome.org/PathwayBrowser/#/R-DDI-9640195 RRAGA,B hydrolyzes GTP IEA Dictyostelium discoideum DDB_G0271882 R-DDI-9645598 https://reactome.org/PathwayBrowser/#/R-DDI-9645598 RRAGC,D hydrolyzes GTP IEA Dictyostelium discoideum DDB_G0271882 R-DDI-9645608 https://reactome.org/PathwayBrowser/#/R-DDI-9645608 v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP binds mTORC1 IEA Dictyostelium discoideum DDB_G0271882 R-DDI-9646468 https://reactome.org/PathwayBrowser/#/R-DDI-9646468 mTORC1 binds RHEB:GTP IEA Dictyostelium discoideum DDB_G0271890 R-DDI-9647991 https://reactome.org/PathwayBrowser/#/R-DDI-9647991 Palmostatin B binds RAS depalmitoylases IEA Dictyostelium discoideum DDB_G0271904 R-DDI-372819 https://reactome.org/PathwayBrowser/#/R-DDI-372819 PCK2 phosphorylates OA to yield PEP IEA Dictyostelium discoideum DDB_G0271904 R-DDI-70241 https://reactome.org/PathwayBrowser/#/R-DDI-70241 PCK1 phosphorylates OA to yield PEP IEA Dictyostelium discoideum DDB_G0271908 R-DDI-8866277 https://reactome.org/PathwayBrowser/#/R-DDI-8866277 AP-2 directly binds some endocytic cargo IEA Dictyostelium discoideum DDB_G0271908 R-DDI-8868072 https://reactome.org/PathwayBrowser/#/R-DDI-8868072 Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2 IEA Dictyostelium discoideum DDB_G0271924 R-DDI-6797627 https://reactome.org/PathwayBrowser/#/R-DDI-6797627 ASPG hydrolyses L-Asn to L-Asp IEA Dictyostelium discoideum DDB_G0271956 R-DDI-983140 https://reactome.org/PathwayBrowser/#/R-DDI-983140 Transfer of Ub from E2 to substrate and release of E2 IEA Dictyostelium discoideum DDB_G0271956 R-DDI-983147 https://reactome.org/PathwayBrowser/#/R-DDI-983147 Release of E3 from polyubiquitinated substrate IEA Dictyostelium discoideum DDB_G0271956 R-DDI-983156 https://reactome.org/PathwayBrowser/#/R-DDI-983156 Polyubiquitination of substrate IEA Dictyostelium discoideum DDB_G0271956 R-DDI-983157 https://reactome.org/PathwayBrowser/#/R-DDI-983157 Interaction of E3 with substrate and E2-Ub complex IEA Dictyostelium discoideum DDB_G0271960 R-DDI-2993799 https://reactome.org/PathwayBrowser/#/R-DDI-2993799 HLCS biotinylates 6xMCCC1:6xMCCC2 IEA Dictyostelium discoideum DDB_G0271960 R-DDI-3323111 https://reactome.org/PathwayBrowser/#/R-DDI-3323111 Cytoslic carboxylases translocate to mitochondrial matrix IEA Dictyostelium discoideum DDB_G0271960 R-DDI-508308 https://reactome.org/PathwayBrowser/#/R-DDI-508308 beta-methylglutaconyl-CoA + ADP + orthophosphate <=> beta-methylcrotonyl-CoA + ATP + CO2 (MCCA) IEA Dictyostelium discoideum DDB_G0271960 R-DDI-70773 https://reactome.org/PathwayBrowser/#/R-DDI-70773 beta-methylcrotonyl-CoA + ATP + CO2 <=> beta-methylglutaconyl-CoA + ADP + orthophosphate + H2O [MCCA] IEA Dictyostelium discoideum DDB_G0271968 R-DDI-204008 https://reactome.org/PathwayBrowser/#/R-DDI-204008 SEC31:SEC13 and v-SNARE recruitment IEA Dictyostelium discoideum DDB_G0271968 R-DDI-5694409 https://reactome.org/PathwayBrowser/#/R-DDI-5694409 Nucleotide exchange on RAB1 IEA Dictyostelium discoideum DDB_G0271968 R-DDI-5694428 https://reactome.org/PathwayBrowser/#/R-DDI-5694428 LMAN family proteins bind glycosylated cargo IEA Dictyostelium discoideum DDB_G0271968 R-DDI-5694439 https://reactome.org/PathwayBrowser/#/R-DDI-5694439 COPII coat binds TRAPPCII and RAB1:GDP IEA Dictyostelium discoideum DDB_G0271968 R-DDI-5694441 https://reactome.org/PathwayBrowser/#/R-DDI-5694441 CSNK1D phosphorylates SEC23 IEA Dictyostelium discoideum DDB_G0271968 R-DDI-5694522 https://reactome.org/PathwayBrowser/#/R-DDI-5694522 Inner coat assembly and cargo binding IEA Dictyostelium discoideum DDB_G0271968 R-DDI-5694527 https://reactome.org/PathwayBrowser/#/R-DDI-5694527 Loss of SAR1B GTPase IEA Dictyostelium discoideum DDB_G0271976 R-DDI-156826 https://reactome.org/PathwayBrowser/#/R-DDI-156826 Dissociation of L13a from the 60s ribosomal subunit IEA Dictyostelium discoideum DDB_G0271976 R-DDI-1799332 https://reactome.org/PathwayBrowser/#/R-DDI-1799332 Nascent polypeptide:mRNA:ribosome complex binds signal recognition particle (SRP) IEA Dictyostelium discoideum DDB_G0271976 R-DDI-72671 https://reactome.org/PathwayBrowser/#/R-DDI-72671 eIF5B:GTP is hydrolyzed and released IEA Dictyostelium discoideum DDB_G0271976 R-DDI-72672 https://reactome.org/PathwayBrowser/#/R-DDI-72672 The 60S subunit joins the translation initiation complex IEA Dictyostelium discoideum DDB_G0271976 R-DDI-72673 https://reactome.org/PathwayBrowser/#/R-DDI-72673 Release of 40S and 60S subunits from the 80S ribosome IEA Dictyostelium discoideum DDB_G0271976 R-DDI-927789 https://reactome.org/PathwayBrowser/#/R-DDI-927789 Formation of UPF1:eRF3 complex on mRNA with a premature termination codon and no Exon Junction Complex IEA Dictyostelium discoideum DDB_G0271976 R-DDI-927832 https://reactome.org/PathwayBrowser/#/R-DDI-927832 UPF1 binds an mRNP with a termination codon preceding an Exon Junction Complex IEA Dictyostelium discoideum DDB_G0271976 R-DDI-927889 https://reactome.org/PathwayBrowser/#/R-DDI-927889 SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex) IEA Dictyostelium discoideum DDB_G0271980 R-DDI-6798739 https://reactome.org/PathwayBrowser/#/R-DDI-6798739 Exocytosis of azurophil granule membrane proteins IEA Dictyostelium discoideum DDB_G0271980 R-DDI-6798749 https://reactome.org/PathwayBrowser/#/R-DDI-6798749 Exocytosis of specific granule lumen proteins IEA Dictyostelium discoideum DDB_G0271980 R-DDI-6799350 https://reactome.org/PathwayBrowser/#/R-DDI-6799350 Exocytosis of specific granule membrane proteins IEA Dictyostelium discoideum DDB_G0271980 R-DDI-8870466 https://reactome.org/PathwayBrowser/#/R-DDI-8870466 RGGT:CHM binds RABs IEA Dictyostelium discoideum DDB_G0271980 R-DDI-8870469 https://reactome.org/PathwayBrowser/#/R-DDI-8870469 RGGT geranylgeranylates RAB proteins IEA Dictyostelium discoideum DDB_G0271984 R-DDI-6798739 https://reactome.org/PathwayBrowser/#/R-DDI-6798739 Exocytosis of azurophil granule membrane proteins IEA Dictyostelium discoideum DDB_G0271984 R-DDI-6798743 https://reactome.org/PathwayBrowser/#/R-DDI-6798743 Exocytosis of secretory granule membrane proteins IEA Dictyostelium discoideum DDB_G0271984 R-DDI-8870466 https://reactome.org/PathwayBrowser/#/R-DDI-8870466 RGGT:CHM binds RABs IEA Dictyostelium discoideum DDB_G0271984 R-DDI-8870469 https://reactome.org/PathwayBrowser/#/R-DDI-8870469 RGGT geranylgeranylates RAB proteins IEA Dictyostelium discoideum DDB_G0271984 R-DDI-8875320 https://reactome.org/PathwayBrowser/#/R-DDI-8875320 RAB5 GEFs exchange GTP for GDP on RAB5 IEA Dictyostelium discoideum DDB_G0272004 R-DDI-139855 https://reactome.org/PathwayBrowser/#/R-DDI-139855 P2X1-mediated entry of Ca++ from plasma IEA Dictyostelium discoideum DDB_G0272004 R-DDI-419490 https://reactome.org/PathwayBrowser/#/R-DDI-419490 Binding of ATP to P2X receptors IEA Dictyostelium discoideum DDB_G0272004 R-DDI-6798743 https://reactome.org/PathwayBrowser/#/R-DDI-6798743 Exocytosis of secretory granule membrane proteins IEA Dictyostelium discoideum DDB_G0272004 R-DDI-6799350 https://reactome.org/PathwayBrowser/#/R-DDI-6799350 Exocytosis of specific granule membrane proteins IEA Dictyostelium discoideum DDB_G0272004 R-DDI-877187 https://reactome.org/PathwayBrowser/#/R-DDI-877187 P2X7 mediates loss of intracellular K+ IEA Dictyostelium discoideum DDB_G0272012 R-DDI-2046088 https://reactome.org/PathwayBrowser/#/R-DDI-2046088 Elongation of stearidonoyl-CoA to eicosatetraenoyl-CoA IEA Dictyostelium discoideum DDB_G0272012 R-DDI-2046094 https://reactome.org/PathwayBrowser/#/R-DDI-2046094 Elongation of gamma-lenolenoyl-CoA to dihomo-gamma-lenolenoyl-CoA IEA Dictyostelium discoideum DDB_G0272012 R-DDI-548800 https://reactome.org/PathwayBrowser/#/R-DDI-548800 ELOVL1,2,3,5 elongate AA-CoA and Mal-CoA to 3ODCT-CoA IEA Dictyostelium discoideum DDB_G0272012 R-DDI-548814 https://reactome.org/PathwayBrowser/#/R-DDI-548814 ELOVL3,6,7 elongate PALM-CoA and Mal-CoA to 3OOD-CoA IEA Dictyostelium discoideum DDB_G0272016 R-DDI-8952039 https://reactome.org/PathwayBrowser/#/R-DDI-8952039 NEDD8:AcM-UBE2F binds CRL5 E3 ubiquitin ligase complex IEA Dictyostelium discoideum DDB_G0272016 R-DDI-8952044 https://reactome.org/PathwayBrowser/#/R-DDI-8952044 AcM-UBE2F transfers NEDD8 to CRL5 E3 ubiquitin ligase complex IEA Dictyostelium discoideum DDB_G0272016 R-DDI-8952618 https://reactome.org/PathwayBrowser/#/R-DDI-8952618 AcM-UBE2M transfers NEDD8 to CRL1 E3 ubiquitin ligase complex IEA Dictyostelium discoideum DDB_G0272016 R-DDI-8952620 https://reactome.org/PathwayBrowser/#/R-DDI-8952620 NEDD8:AcM-UBE2M binds CRL1 E3 ubiquitin ligase complex IEA Dictyostelium discoideum DDB_G0272016 R-DDI-8952626 https://reactome.org/PathwayBrowser/#/R-DDI-8952626 AcM-UBE2M transfers NEDD8 to CRL2 E3 ubiquitin ligase complex IEA Dictyostelium discoideum DDB_G0272016 R-DDI-8952630 https://reactome.org/PathwayBrowser/#/R-DDI-8952630 NEDD8:AcM-UBE2M binds CRL3 E3 ubiquitin ligase complex IEA Dictyostelium discoideum DDB_G0272016 R-DDI-8952631 https://reactome.org/PathwayBrowser/#/R-DDI-8952631 AcM-UBE2M transfers NEDD8 to CRL3 E3 ubiquitin ligase complex IEA Dictyostelium discoideum DDB_G0272016 R-DDI-8952638 https://reactome.org/PathwayBrowser/#/R-DDI-8952638 AcM-UBE2M transfers NEDD8 to CRL4 E3 ubiquitin ligase complex IEA Dictyostelium discoideum DDB_G0272016 R-DDI-8952639 https://reactome.org/PathwayBrowser/#/R-DDI-8952639 NEDD8:AcM-UBE2M binds CRL4 E3 ubiquitin ligase complex IEA Dictyostelium discoideum DDB_G0272016 R-DDI-8956040 https://reactome.org/PathwayBrowser/#/R-DDI-8956040 COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes IEA Dictyostelium discoideum DDB_G0272016 R-DDI-8956045 https://reactome.org/PathwayBrowser/#/R-DDI-8956045 COP9 signalosome deneddylates nuclear CRL4 E3 ubiquitin ligase complex IEA Dictyostelium discoideum DDB_G0272016 R-DDI-8956099 https://reactome.org/PathwayBrowser/#/R-DDI-8956099 VHL:EloB,C:NEDD8-CUL2:RBX1 complex binds UBXN7 IEA Dictyostelium discoideum DDB_G0272018 R-DDI-191380 https://reactome.org/PathwayBrowser/#/R-DDI-191380 Mevalonate is phosphorylated to mevalonate-5-phosphate IEA Dictyostelium discoideum DDB_G0272022 R-DDI-76056 https://reactome.org/PathwayBrowser/#/R-DDI-76056 Recruitment of RNA polymerase III to TFIIIB:TFIIIC:TFIIIA:Type 1 Promoter Complex IEA Dictyostelium discoideum DDB_G0272022 R-DDI-83805 https://reactome.org/PathwayBrowser/#/R-DDI-83805 Recruitment of RNA Polymerase III to the TFIIIB:TFIIIC: Type 2 Promoter Complex IEA Dictyostelium discoideum DDB_G0272032 R-DDI-205039 https://reactome.org/PathwayBrowser/#/R-DDI-205039 p75NTR indirectly activates RAC and Cdc42 via a guanyl-nucleotide exchange factor IEA Dictyostelium discoideum DDB_G0272032 R-DDI-9013143 https://reactome.org/PathwayBrowser/#/R-DDI-9013143 RAC1 GEFs activate RAC1 IEA Dictyostelium discoideum DDB_G0272032 R-DDI-9013159 https://reactome.org/PathwayBrowser/#/R-DDI-9013159 CDC42 GEFs activate CDC42 IEA Dictyostelium discoideum DDB_G0272036 R-DDI-109638 https://reactome.org/PathwayBrowser/#/R-DDI-109638 Recruitment of RNA Polymerase II Holoenzyme by TFIIF to the pol II promoter:TFIID:TFIIA:TFIIB complex IEA Dictyostelium discoideum DDB_G0272036 R-DDI-109639 https://reactome.org/PathwayBrowser/#/R-DDI-109639 Formation of the closed pre-initiation complex IEA Dictyostelium discoideum DDB_G0272036 R-DDI-111264 https://reactome.org/PathwayBrowser/#/R-DDI-111264 Addition of nucleotides between position +11 and +30 IEA Dictyostelium discoideum DDB_G0272036 R-DDI-112383 https://reactome.org/PathwayBrowser/#/R-DDI-112383 Hypophosphorylation of RNA Pol II CTD by FCP1P protein IEA Dictyostelium discoideum DDB_G0272036 R-DDI-113407 https://reactome.org/PathwayBrowser/#/R-DDI-113407 DSIF complex binds to RNA Pol II (hypophosphorylated) IEA Dictyostelium discoideum DDB_G0272036 R-DDI-113409 https://reactome.org/PathwayBrowser/#/R-DDI-113409 Abortive termination of early transcription elongation by DSIF:NELF IEA Dictyostelium discoideum DDB_G0272036 R-DDI-113430 https://reactome.org/PathwayBrowser/#/R-DDI-113430 Extrusion of 5'-end of 30 nt long transcript through the pore in Pol II complex IEA Dictyostelium discoideum DDB_G0272036 R-DDI-6781818 https://reactome.org/PathwayBrowser/#/R-DDI-6781818 RNA Pol II initiates transcription from damaged DNA template IEA Dictyostelium discoideum DDB_G0272036 R-DDI-6781824 https://reactome.org/PathwayBrowser/#/R-DDI-6781824 Active RNA Pol II complex transcribes lesion-containing DNA template IEA Dictyostelium discoideum DDB_G0272036 R-DDI-6781833 https://reactome.org/PathwayBrowser/#/R-DDI-6781833 ERCC8 (CSA) binds stalled RNA Pol II IEA Dictyostelium discoideum DDB_G0272036 R-DDI-6781840 https://reactome.org/PathwayBrowser/#/R-DDI-6781840 ERCC6 binds stalled RNA Pol II IEA Dictyostelium discoideum DDB_G0272036 R-DDI-6781867 https://reactome.org/PathwayBrowser/#/R-DDI-6781867 ERCC8:DDB1:CUL4:RBX1 ubiquitinates ERCC6 and RNA Pol II IEA Dictyostelium discoideum DDB_G0272036 R-DDI-6782069 https://reactome.org/PathwayBrowser/#/R-DDI-6782069 UVSSA:USP7 deubiquitinates ERCC6 IEA Dictyostelium discoideum DDB_G0272036 R-DDI-6782131 https://reactome.org/PathwayBrowser/#/R-DDI-6782131 ERCC2-facilitated RNA Pol II backtracking in TC-NER IEA Dictyostelium discoideum DDB_G0272036 R-DDI-6782141 https://reactome.org/PathwayBrowser/#/R-DDI-6782141 Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in TC-NER IEA Dictyostelium discoideum DDB_G0272036 R-DDI-6782204 https://reactome.org/PathwayBrowser/#/R-DDI-6782204 5' incision of damaged DNA strand by ERCC1:ERCC4 in TC-NER IEA Dictyostelium discoideum DDB_G0272036 R-DDI-6782208 https://reactome.org/PathwayBrowser/#/R-DDI-6782208 Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in TC-NER IEA Dictyostelium discoideum DDB_G0272036 R-DDI-6782211 https://reactome.org/PathwayBrowser/#/R-DDI-6782211 DNA polymerases delta, epsilon or kappa bind the TC-NER site IEA Dictyostelium discoideum DDB_G0272036 R-DDI-6782227 https://reactome.org/PathwayBrowser/#/R-DDI-6782227 Ligation of newly synthesized repair patch to incised DNA in TC-NER IEA Dictyostelium discoideum DDB_G0272036 R-DDI-6797606 https://reactome.org/PathwayBrowser/#/R-DDI-6797606 CDK12 phosphorylates RNA Pol II CTD at DNA repair genes IEA Dictyostelium discoideum DDB_G0272036 R-DDI-6797616 https://reactome.org/PathwayBrowser/#/R-DDI-6797616 CCNK:CDK12 binds RNA Pol II at DNA repair genes IEA Dictyostelium discoideum DDB_G0272036 R-DDI-6810233 https://reactome.org/PathwayBrowser/#/R-DDI-6810233 CDK7 phosphorylates serine-5 and serine-7 of heptad repeats in C-terminal domain of RNA polymerase II at snRNA promoter IEA Dictyostelium discoideum DDB_G0272036 R-DDI-6810238 https://reactome.org/PathwayBrowser/#/R-DDI-6810238 RNA polymerase II binds initiation factors at promoter of snRNA gene (U1, U2, U4, U4atac, U5, U11, U12) IEA Dictyostelium discoideum DDB_G0272036 R-DDI-6814555 https://reactome.org/PathwayBrowser/#/R-DDI-6814555 Integrator complex processes the 3' end of snRNA IEA Dictyostelium discoideum DDB_G0272036 R-DDI-6814559 https://reactome.org/PathwayBrowser/#/R-DDI-6814559 Pre-snRNA is elongated and capped with 7-methylguanosine IEA Dictyostelium discoideum DDB_G0272036 R-DDI-72103 https://reactome.org/PathwayBrowser/#/R-DDI-72103 Formation of pre-mRNPs IEA Dictyostelium discoideum DDB_G0272036 R-DDI-73757 https://reactome.org/PathwayBrowser/#/R-DDI-73757 Binding of RRN3 to RNA Polymerase I IEA Dictyostelium discoideum DDB_G0272036 R-DDI-73769 https://reactome.org/PathwayBrowser/#/R-DDI-73769 Loss of Rrn3 from RNA Polymerase I promoter escape complex IEA Dictyostelium discoideum DDB_G0272036 R-DDI-73946 https://reactome.org/PathwayBrowser/#/R-DDI-73946 Abortive initiation after formation of the first phosphodiester bond IEA Dictyostelium discoideum DDB_G0272036 R-DDI-74986 https://reactome.org/PathwayBrowser/#/R-DDI-74986 Elongation of pre-rRNA transcript IEA Dictyostelium discoideum DDB_G0272036 R-DDI-75095 https://reactome.org/PathwayBrowser/#/R-DDI-75095 Binding of TFIIE to the growing preinitiation complex IEA Dictyostelium discoideum DDB_G0272036 R-DDI-75850 https://reactome.org/PathwayBrowser/#/R-DDI-75850 Addition of the third nucleotide on the nascent transcript IEA Dictyostelium discoideum DDB_G0272036 R-DDI-75856 https://reactome.org/PathwayBrowser/#/R-DDI-75856 Abortive Initiation Before Second Transition IEA Dictyostelium discoideum DDB_G0272036 R-DDI-75861 https://reactome.org/PathwayBrowser/#/R-DDI-75861 NTP Binds Active Site of RNA Polymerase II IEA Dictyostelium discoideum DDB_G0272036 R-DDI-75862 https://reactome.org/PathwayBrowser/#/R-DDI-75862 Fall Back to Closed Pre-initiation Complex IEA Dictyostelium discoideum DDB_G0272036 R-DDI-75864 https://reactome.org/PathwayBrowser/#/R-DDI-75864 Newly Formed Phosphodiester Bond Stabilized and PPi Released IEA Dictyostelium discoideum DDB_G0272036 R-DDI-75866 https://reactome.org/PathwayBrowser/#/R-DDI-75866 Nucleophillic Attack by 3'-hydroxyl Oxygen of nascent transcript on the Alpha Phosphate of NTP IEA Dictyostelium discoideum DDB_G0272036 R-DDI-75869 https://reactome.org/PathwayBrowser/#/R-DDI-75869 Addition of the fourth nucleotide on the Nascent Transcript: Second Transition IEA Dictyostelium discoideum DDB_G0272036 R-DDI-75873 https://reactome.org/PathwayBrowser/#/R-DDI-75873 Addition of Nucleotides 5 through 9 on the growing Transcript IEA Dictyostelium discoideum DDB_G0272036 R-DDI-75891 https://reactome.org/PathwayBrowser/#/R-DDI-75891 Abortive Initiation After Second Transition IEA Dictyostelium discoideum DDB_G0272036 R-DDI-75949 https://reactome.org/PathwayBrowser/#/R-DDI-75949 RNA Polymerase II Promoter Opening: First Transition IEA Dictyostelium discoideum DDB_G0272036 R-DDI-76056 https://reactome.org/PathwayBrowser/#/R-DDI-76056 Recruitment of RNA polymerase III to TFIIIB:TFIIIC:TFIIIA:Type 1 Promoter Complex IEA Dictyostelium discoideum DDB_G0272036 R-DDI-76576 https://reactome.org/PathwayBrowser/#/R-DDI-76576 Addition of nucleotides 10 and 11 on the growing transcript: Third Transition IEA Dictyostelium discoideum DDB_G0272036 R-DDI-77068 https://reactome.org/PathwayBrowser/#/R-DDI-77068 Activation of GT IEA Dictyostelium discoideum DDB_G0272036 R-DDI-77069 https://reactome.org/PathwayBrowser/#/R-DDI-77069 RNA Polymerase II CTD (phosphorylated) binds to CE IEA Dictyostelium discoideum DDB_G0272036 R-DDI-77071 https://reactome.org/PathwayBrowser/#/R-DDI-77071 Phosphorylation (Ser5) of RNA pol II CTD IEA Dictyostelium discoideum DDB_G0272036 R-DDI-77073 https://reactome.org/PathwayBrowser/#/R-DDI-77073 SPT5 subunit of Pol II binds the RNA triphosphatase (RTP) IEA Dictyostelium discoideum DDB_G0272036 R-DDI-77077 https://reactome.org/PathwayBrowser/#/R-DDI-77077 Capping complex formation IEA Dictyostelium discoideum DDB_G0272036 R-DDI-77078 https://reactome.org/PathwayBrowser/#/R-DDI-77078 Hydrolysis of the 5'-end of the nascent transcript by the capping enzyme IEA Dictyostelium discoideum DDB_G0272036 R-DDI-77081 https://reactome.org/PathwayBrowser/#/R-DDI-77081 Formation of the CE:GMP intermediate complex IEA Dictyostelium discoideum DDB_G0272036 R-DDI-77083 https://reactome.org/PathwayBrowser/#/R-DDI-77083 Transfer of GMP from the capping enzyme GT site to 5'-end of mRNA IEA Dictyostelium discoideum DDB_G0272036 R-DDI-77085 https://reactome.org/PathwayBrowser/#/R-DDI-77085 Dissociation of transcript with 5'-GMP from GT IEA Dictyostelium discoideum DDB_G0272036 R-DDI-77090 https://reactome.org/PathwayBrowser/#/R-DDI-77090 Methylation of GMP-cap by RNA Methyltransferase IEA Dictyostelium discoideum DDB_G0272036 R-DDI-77095 https://reactome.org/PathwayBrowser/#/R-DDI-77095 Recognition and binding of the mRNA cap by the cap-binding complex IEA Dictyostelium discoideum DDB_G0272036 R-DDI-83805 https://reactome.org/PathwayBrowser/#/R-DDI-83805 Recruitment of RNA Polymerase III to the TFIIIB:TFIIIC: Type 2 Promoter Complex IEA Dictyostelium discoideum DDB_G0272036 R-DDI-9012319 https://reactome.org/PathwayBrowser/#/R-DDI-9012319 p-TEFb phosphorylates serine 2 in RNA polymerase II CTD IEA Dictyostelium discoideum DDB_G0272036 R-DDI-9613494 https://reactome.org/PathwayBrowser/#/R-DDI-9613494 Unwinding of DNA for the Nascent Transcript: Second Transition IEA Dictyostelium discoideum DDB_G0272036 R-DDI-9613497 https://reactome.org/PathwayBrowser/#/R-DDI-9613497 Unwinding DNA for the nascent transcript IEA Dictyostelium discoideum DDB_G0272036 R-DDI-9684118 https://reactome.org/PathwayBrowser/#/R-DDI-9684118 ERCC3-facilitated RNA Pol II backtracking in TC-NER IEA Dictyostelium discoideum DDB_G0272036 R-DDI-9770236 https://reactome.org/PathwayBrowser/#/R-DDI-9770236 Formation of the Spliceosomal P complex and exon ligation IEA Dictyostelium discoideum DDB_G0272038 R-DDI-8875320 https://reactome.org/PathwayBrowser/#/R-DDI-8875320 RAB5 GEFs exchange GTP for GDP on RAB5 IEA Dictyostelium discoideum DDB_G0272048 R-DDI-6809287 https://reactome.org/PathwayBrowser/#/R-DDI-6809287 NUDT12 hydrolyses NADH to NMNH IEA Dictyostelium discoideum DDB_G0272056 R-DDI-6798044 https://reactome.org/PathwayBrowser/#/R-DDI-6798044 BTG2 binds CCR4-NOT complex IEA Dictyostelium discoideum DDB_G0272076 R-DDI-156823 https://reactome.org/PathwayBrowser/#/R-DDI-156823 Association of phospho-L13a with GAIT element of Ceruloplasmin mRNA IEA Dictyostelium discoideum DDB_G0272076 R-DDI-72621 https://reactome.org/PathwayBrowser/#/R-DDI-72621 Ribosomal scanning IEA Dictyostelium discoideum DDB_G0272076 R-DDI-72676 https://reactome.org/PathwayBrowser/#/R-DDI-72676 eIF3 and eIF1A bind to the 40S subunit IEA Dictyostelium discoideum DDB_G0272076 R-DDI-72691 https://reactome.org/PathwayBrowser/#/R-DDI-72691 Formation of the 43S pre-initiation complex IEA Dictyostelium discoideum DDB_G0272076 R-DDI-72697 https://reactome.org/PathwayBrowser/#/R-DDI-72697 Start codon recognition IEA Dictyostelium discoideum DDB_G0272078 R-DDI-156823 https://reactome.org/PathwayBrowser/#/R-DDI-156823 Association of phospho-L13a with GAIT element of Ceruloplasmin mRNA IEA Dictyostelium discoideum DDB_G0272078 R-DDI-72621 https://reactome.org/PathwayBrowser/#/R-DDI-72621 Ribosomal scanning IEA Dictyostelium discoideum DDB_G0272078 R-DDI-72676 https://reactome.org/PathwayBrowser/#/R-DDI-72676 eIF3 and eIF1A bind to the 40S subunit IEA Dictyostelium discoideum DDB_G0272078 R-DDI-72691 https://reactome.org/PathwayBrowser/#/R-DDI-72691 Formation of the 43S pre-initiation complex IEA Dictyostelium discoideum DDB_G0272078 R-DDI-72697 https://reactome.org/PathwayBrowser/#/R-DDI-72697 Start codon recognition IEA Dictyostelium discoideum DDB_G0272092 R-DDI-5672948 https://reactome.org/PathwayBrowser/#/R-DDI-5672948 MARK3 phosphorylates KSR1 IEA Dictyostelium discoideum DDB_G0272092 R-DDI-5674019 https://reactome.org/PathwayBrowser/#/R-DDI-5674019 BRAP binds KSR1:MARK3 IEA Dictyostelium discoideum DDB_G0272104 R-DDI-6809003 https://reactome.org/PathwayBrowser/#/R-DDI-6809003 ERGIC-to-Golgi vesicles bind dynein:dynactin IEA Dictyostelium discoideum DDB_G0272104 R-DDI-879459 https://reactome.org/PathwayBrowser/#/R-DDI-879459 F-actin capping protein is a heterodimer IEA Dictyostelium discoideum DDB_G0272104 R-DDI-994148 https://reactome.org/PathwayBrowser/#/R-DDI-994148 LRRC16A binds F-actin capping protein IEA Dictyostelium discoideum DDB_G0272106 R-DDI-2029466 https://reactome.org/PathwayBrowser/#/R-DDI-2029466 (WASPs, WAVE):G-actin:ARP2/3 binds F-actin IEA Dictyostelium discoideum DDB_G0272106 R-DDI-2029473 https://reactome.org/PathwayBrowser/#/R-DDI-2029473 Branching and elongation of mother and daughter filaments IEA Dictyostelium discoideum DDB_G0272106 R-DDI-2197690 https://reactome.org/PathwayBrowser/#/R-DDI-2197690 Detachment of WASP/WAVE IEA Dictyostelium discoideum DDB_G0272106 R-DDI-6798751 https://reactome.org/PathwayBrowser/#/R-DDI-6798751 Exocytosis of azurophil granule lumen proteins IEA Dictyostelium discoideum DDB_G0272106 R-DDI-6800434 https://reactome.org/PathwayBrowser/#/R-DDI-6800434 Exocytosis of ficolin-rich granule lumen proteins IEA Dictyostelium discoideum DDB_G0272110 R-DDI-3371435 https://reactome.org/PathwayBrowser/#/R-DDI-3371435 Constitutive phosphorylation by GSK3 IEA Dictyostelium discoideum DDB_G0272112 R-DDI-9018766 https://reactome.org/PathwayBrowser/#/R-DDI-9018766 RHOU binds effectors at the plasma membrane IEA Dictyostelium discoideum DDB_G0272112 R-DDI-9018778 https://reactome.org/PathwayBrowser/#/R-DDI-9018778 RHOBTB1 binds interacting proteins at the endosome membrane IEA Dictyostelium discoideum DDB_G0272112 R-DDI-9018787 https://reactome.org/PathwayBrowser/#/R-DDI-9018787 RHOBTB2 binds interacting proteins at the endosome membrane IEA Dictyostelium discoideum DDB_G0272112 R-DDI-9018815 https://reactome.org/PathwayBrowser/#/R-DDI-9018815 RHOT1 binds effectors at the mitochondrial outer membrane IEA Dictyostelium discoideum DDB_G0272112 R-DDI-9018824 https://reactome.org/PathwayBrowser/#/R-DDI-9018824 RHOT2 binds effectors at the mitochondrial outer membrane IEA Dictyostelium discoideum DDB_G0272114 R-DDI-6798747 https://reactome.org/PathwayBrowser/#/R-DDI-6798747 Exocytosis of tertiary granule membrane proteins IEA Dictyostelium discoideum DDB_G0272114 R-DDI-6799350 https://reactome.org/PathwayBrowser/#/R-DDI-6799350 Exocytosis of specific granule membrane proteins IEA Dictyostelium discoideum DDB_G0272118 R-DDI-5694421 https://reactome.org/PathwayBrowser/#/R-DDI-5694421 PP6 dephosphorylates SEC24 IEA Dictyostelium discoideum DDB_G0272120 R-DDI-9838627 https://reactome.org/PathwayBrowser/#/R-DDI-9838627 AFG3L2 binds mitochondrial inner membrane proteins IEA Dictyostelium discoideum DDB_G0272120 R-DDI-9839105 https://reactome.org/PathwayBrowser/#/R-DDI-9839105 AFG3L2 degrades mitochondrial matrix proteins IEA Dictyostelium discoideum DDB_G0272120 R-DDI-9839113 https://reactome.org/PathwayBrowser/#/R-DDI-9839113 AFG3L2 degrades mitochondrial inner membrane proteins IEA Dictyostelium discoideum DDB_G0272120 R-DDI-9839149 https://reactome.org/PathwayBrowser/#/R-DDI-9839149 AFG3L2 binds mitochondrial matrix proteins IEA Dictyostelium discoideum DDB_G0272124 R-DDI-6807875 https://reactome.org/PathwayBrowser/#/R-DDI-6807875 ARFGAP, cargo, v-SNAREs and p24 proteins bind nascent COPI complex IEA Dictyostelium discoideum DDB_G0272124 R-DDI-6807877 https://reactome.org/PathwayBrowser/#/R-DDI-6807877 ARFGAPs stimulate ARF GTPase activity IEA Dictyostelium discoideum DDB_G0272124 R-DDI-6809003 https://reactome.org/PathwayBrowser/#/R-DDI-6809003 ERGIC-to-Golgi vesicles bind dynein:dynactin IEA Dictyostelium discoideum DDB_G0272124 R-DDI-6809011 https://reactome.org/PathwayBrowser/#/R-DDI-6809011 cis-Golgi t-SNAREs bind YKT6 on tethered vesicle IEA Dictyostelium discoideum DDB_G0272124 R-DDI-6811417 https://reactome.org/PathwayBrowser/#/R-DDI-6811417 ARFGAP, cargo, vSNARES and p24 proteins bind COPI vesicles at Golgi IEA Dictyostelium discoideum DDB_G0272124 R-DDI-6811418 https://reactome.org/PathwayBrowser/#/R-DDI-6811418 ARFGAPs stimulate ARF GTPase activity at the Golgi membrane IEA Dictyostelium discoideum DDB_G0272124 R-DDI-6811427 https://reactome.org/PathwayBrowser/#/R-DDI-6811427 COPI vesicle uncoating at the ER IEA Dictyostelium discoideum DDB_G0272128 R-DDI-508369 https://reactome.org/PathwayBrowser/#/R-DDI-508369 alpha-methylacetoacetyl-CoA + NADH + H+ <=> alpha-methyl-beta-hydroxybutyryl-CoA + NAD+ IEA Dictyostelium discoideum DDB_G0272128 R-DDI-70837 https://reactome.org/PathwayBrowser/#/R-DDI-70837 alpha-methyl-beta-hydroxybutyryl-CoA + NAD+ <=> alpha-methylacetoacetyl-CoA + NADH + H+ IEA Dictyostelium discoideum DDB_G0272128 R-DDI-9838081 https://reactome.org/PathwayBrowser/#/R-DDI-9838081 LONP1 degrades mitochondrial matrix proteins IEA Dictyostelium discoideum DDB_G0272128 R-DDI-9838093 https://reactome.org/PathwayBrowser/#/R-DDI-9838093 LONP1 binds mitochondrial matrix proteins IEA Dictyostelium discoideum DDB_G0272130 R-DDI-2586748 https://reactome.org/PathwayBrowser/#/R-DDI-2586748 GUCA binds Ca2+ to form GUCA:Ca2+ IEA Dictyostelium discoideum DDB_G0272130 R-DDI-74885 https://reactome.org/PathwayBrowser/#/R-DDI-74885 GUCYs converts GTP to cGMP IEA Dictyostelium discoideum DDB_G0272138 R-DDI-8849748 https://reactome.org/PathwayBrowser/#/R-DDI-8849748 The COG complex binds RABs at the Golgi membrane IEA Dictyostelium discoideum DDB_G0272138 R-DDI-8870466 https://reactome.org/PathwayBrowser/#/R-DDI-8870466 RGGT:CHM binds RABs IEA Dictyostelium discoideum DDB_G0272138 R-DDI-8870469 https://reactome.org/PathwayBrowser/#/R-DDI-8870469 RGGT geranylgeranylates RAB proteins IEA Dictyostelium discoideum DDB_G0272170 R-DDI-975926 https://reactome.org/PathwayBrowser/#/R-DDI-975926 Addition of a bifurcating GlcNAc to the N-glycan by MGAT3 IEA Dictyostelium discoideum DDB_G0272176 R-DDI-6791219 https://reactome.org/PathwayBrowser/#/R-DDI-6791219 32S pre-rRNA is nucleolytically processed at site 4 (4a) to yield 12S pre-rRNA and 28S rRNA IEA Dictyostelium discoideum DDB_G0272190 R-DDI-481007 https://reactome.org/PathwayBrowser/#/R-DDI-481007 Exocytosis of platelet alpha granule contents IEA Dictyostelium discoideum DDB_G0272202 R-DDI-983140 https://reactome.org/PathwayBrowser/#/R-DDI-983140 Transfer of Ub from E2 to substrate and release of E2 IEA Dictyostelium discoideum DDB_G0272202 R-DDI-983147 https://reactome.org/PathwayBrowser/#/R-DDI-983147 Release of E3 from polyubiquitinated substrate IEA Dictyostelium discoideum DDB_G0272202 R-DDI-983156 https://reactome.org/PathwayBrowser/#/R-DDI-983156 Polyubiquitination of substrate IEA Dictyostelium discoideum DDB_G0272202 R-DDI-983157 https://reactome.org/PathwayBrowser/#/R-DDI-983157 Interaction of E3 with substrate and E2-Ub complex IEA Dictyostelium discoideum DDB_G0272210 R-DDI-389540 https://reactome.org/PathwayBrowser/#/R-DDI-389540 isocitrate + NADP+ => 2-oxoglutarate + CO2 + NADPH + H+ IEA Dictyostelium discoideum DDB_G0272210 R-DDI-389550 https://reactome.org/PathwayBrowser/#/R-DDI-389550 isocitrate + NADP+ => 2-oxoglutarate + CO2 + NADPH + H+ IEA Dictyostelium discoideum DDB_G0272210 R-DDI-6798745 https://reactome.org/PathwayBrowser/#/R-DDI-6798745 Exocytosis of tertiary granule lumen proteins IEA Dictyostelium discoideum DDB_G0272210 R-DDI-6798748 https://reactome.org/PathwayBrowser/#/R-DDI-6798748 Exocytosis of secretory granule lumen proteins IEA Dictyostelium discoideum DDB_G0272210 R-DDI-6800434 https://reactome.org/PathwayBrowser/#/R-DDI-6800434 Exocytosis of ficolin-rich granule lumen proteins IEA Dictyostelium discoideum DDB_G0272210 R-DDI-9033235 https://reactome.org/PathwayBrowser/#/R-DDI-9033235 Cargo of PEX5S,L translocates from the cytosol to the peroxisomal matrix IEA Dictyostelium discoideum DDB_G0272210 R-DDI-9033236 https://reactome.org/PathwayBrowser/#/R-DDI-9033236 PEX5S,L:Cargo binds PEX13:PEX14:PEX2:PEX10:PEX12 (Docking and Translocation Module) IEA Dictyostelium discoideum DDB_G0272218 R-DDI-481009 https://reactome.org/PathwayBrowser/#/R-DDI-481009 Exocytosis of platelet dense granule content IEA Dictyostelium discoideum DDB_G0272218 R-DDI-8952630 https://reactome.org/PathwayBrowser/#/R-DDI-8952630 NEDD8:AcM-UBE2M binds CRL3 E3 ubiquitin ligase complex IEA Dictyostelium discoideum DDB_G0272218 R-DDI-8952631 https://reactome.org/PathwayBrowser/#/R-DDI-8952631 AcM-UBE2M transfers NEDD8 to CRL3 E3 ubiquitin ligase complex IEA Dictyostelium discoideum DDB_G0272218 R-DDI-8955241 https://reactome.org/PathwayBrowser/#/R-DDI-8955241 CAND1 binds cytosolic CRL E3 ubiquitin ligases IEA Dictyostelium discoideum DDB_G0272218 R-DDI-8955289 https://reactome.org/PathwayBrowser/#/R-DDI-8955289 COMMDs displace CAND1 from cytosolic CRL E3 ubiquitin ligase complexes IEA Dictyostelium discoideum DDB_G0272218 R-DDI-8956040 https://reactome.org/PathwayBrowser/#/R-DDI-8956040 COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes IEA Dictyostelium discoideum DDB_G0272218 R-DDI-983140 https://reactome.org/PathwayBrowser/#/R-DDI-983140 Transfer of Ub from E2 to substrate and release of E2 IEA Dictyostelium discoideum DDB_G0272218 R-DDI-983147 https://reactome.org/PathwayBrowser/#/R-DDI-983147 Release of E3 from polyubiquitinated substrate IEA Dictyostelium discoideum DDB_G0272218 R-DDI-983156 https://reactome.org/PathwayBrowser/#/R-DDI-983156 Polyubiquitination of substrate IEA Dictyostelium discoideum DDB_G0272218 R-DDI-983157 https://reactome.org/PathwayBrowser/#/R-DDI-983157 Interaction of E3 with substrate and E2-Ub complex IEA Dictyostelium discoideum DDB_G0272220 R-DDI-6798747 https://reactome.org/PathwayBrowser/#/R-DDI-6798747 Exocytosis of tertiary granule membrane proteins IEA Dictyostelium discoideum DDB_G0272220 R-DDI-6799350 https://reactome.org/PathwayBrowser/#/R-DDI-6799350 Exocytosis of specific granule membrane proteins IEA Dictyostelium discoideum DDB_G0272222 R-DDI-110364 https://reactome.org/PathwayBrowser/#/R-DDI-110364 PCNA:POLD,POLE:RPA:RFC and FEN1 bind APEX1 IEA Dictyostelium discoideum DDB_G0272222 R-DDI-110368 https://reactome.org/PathwayBrowser/#/R-DDI-110368 POLD,POLE-mediated DNA strand displacement synthesis IEA Dictyostelium discoideum DDB_G0272222 R-DDI-110371 https://reactome.org/PathwayBrowser/#/R-DDI-110371 LIG1 binds APEX1 and PCNA at SSB IEA Dictyostelium discoideum DDB_G0272222 R-DDI-5651805 https://reactome.org/PathwayBrowser/#/R-DDI-5651805 LIG1 bound to APEX1 and PCNA ligates SSB IEA Dictyostelium discoideum DDB_G0272222 R-DDI-5652005 https://reactome.org/PathwayBrowser/#/R-DDI-5652005 RAD18:UBE2B or RBX1:CUL4:DDB1:DTL ubiquitin ligase complex binds PCNA:POLD,POLE:RPA:RFC associated with damaged dsDNA IEA Dictyostelium discoideum DDB_G0272222 R-DDI-5652009 https://reactome.org/PathwayBrowser/#/R-DDI-5652009 RAD18:UBE2B or RBX1:CUL4:DDB1:DTL monoubiquitinates PCNA IEA Dictyostelium discoideum DDB_G0272222 R-DDI-5653838 https://reactome.org/PathwayBrowser/#/R-DDI-5653838 POLD,POLE binds deISGylated PCNA after TLS IEA Dictyostelium discoideum DDB_G0272222 R-DDI-5691001 https://reactome.org/PathwayBrowser/#/R-DDI-5691001 Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in GG-NER IEA Dictyostelium discoideum DDB_G0272222 R-DDI-6782208 https://reactome.org/PathwayBrowser/#/R-DDI-6782208 Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in TC-NER IEA Dictyostelium discoideum DDB_G0272222 R-DDI-6782211 https://reactome.org/PathwayBrowser/#/R-DDI-6782211 DNA polymerases delta, epsilon or kappa bind the TC-NER site IEA Dictyostelium discoideum DDB_G0272222 R-DDI-6782227 https://reactome.org/PathwayBrowser/#/R-DDI-6782227 Ligation of newly synthesized repair patch to incised DNA in TC-NER IEA Dictyostelium discoideum DDB_G0272222 R-DDI-68913 https://reactome.org/PathwayBrowser/#/R-DDI-68913 The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer at the origin IEA Dictyostelium discoideum DDB_G0272222 R-DDI-68914 https://reactome.org/PathwayBrowser/#/R-DDI-68914 DNA polymerase alpha:primase binds at the origin IEA Dictyostelium discoideum DDB_G0272222 R-DDI-68960 https://reactome.org/PathwayBrowser/#/R-DDI-68960 DNA polymerase epsilon binds at the origin IEA Dictyostelium discoideum DDB_G0272236 R-DDI-9825759 https://reactome.org/PathwayBrowser/#/R-DDI-9825759 MAPK-dependent phosphorylation of KARS IEA Dictyostelium discoideum DDB_G0272246 R-DDI-73580 https://reactome.org/PathwayBrowser/#/R-DDI-73580 D-ribose 5-phosphate + ATP => 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + adenosine 5'-monophosphate IEA Dictyostelium discoideum DDB_G0272250 R-DDI-156823 https://reactome.org/PathwayBrowser/#/R-DDI-156823 Association of phospho-L13a with GAIT element of Ceruloplasmin mRNA IEA Dictyostelium discoideum DDB_G0272250 R-DDI-1799332 https://reactome.org/PathwayBrowser/#/R-DDI-1799332 Nascent polypeptide:mRNA:ribosome complex binds signal recognition particle (SRP) IEA Dictyostelium discoideum DDB_G0272250 R-DDI-72621 https://reactome.org/PathwayBrowser/#/R-DDI-72621 Ribosomal scanning IEA Dictyostelium discoideum DDB_G0272250 R-DDI-72671 https://reactome.org/PathwayBrowser/#/R-DDI-72671 eIF5B:GTP is hydrolyzed and released IEA Dictyostelium discoideum DDB_G0272250 R-DDI-72672 https://reactome.org/PathwayBrowser/#/R-DDI-72672 The 60S subunit joins the translation initiation complex IEA Dictyostelium discoideum DDB_G0272250 R-DDI-72673 https://reactome.org/PathwayBrowser/#/R-DDI-72673 Release of 40S and 60S subunits from the 80S ribosome IEA Dictyostelium discoideum DDB_G0272250 R-DDI-72676 https://reactome.org/PathwayBrowser/#/R-DDI-72676 eIF3 and eIF1A bind to the 40S subunit IEA Dictyostelium discoideum DDB_G0272250 R-DDI-72691 https://reactome.org/PathwayBrowser/#/R-DDI-72691 Formation of the 43S pre-initiation complex IEA Dictyostelium discoideum DDB_G0272250 R-DDI-72697 https://reactome.org/PathwayBrowser/#/R-DDI-72697 Start codon recognition IEA Dictyostelium discoideum DDB_G0272250 R-DDI-927789 https://reactome.org/PathwayBrowser/#/R-DDI-927789 Formation of UPF1:eRF3 complex on mRNA with a premature termination codon and no Exon Junction Complex IEA Dictyostelium discoideum DDB_G0272250 R-DDI-927832 https://reactome.org/PathwayBrowser/#/R-DDI-927832 UPF1 binds an mRNP with a termination codon preceding an Exon Junction Complex IEA Dictyostelium discoideum DDB_G0272250 R-DDI-927889 https://reactome.org/PathwayBrowser/#/R-DDI-927889 SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex) IEA Dictyostelium discoideum DDB_G0272254 R-DDI-9793472 https://reactome.org/PathwayBrowser/#/R-DDI-9793472 RIPK3 binds p-S9-PRKN IEA Dictyostelium discoideum DDB_G0272254 R-DDI-9793485 https://reactome.org/PathwayBrowser/#/R-DDI-9793485 PRKN polyubiquitinates RIPK3 IEA Dictyostelium discoideum DDB_G0272260 R-DDI-428664 https://reactome.org/PathwayBrowser/#/R-DDI-428664 SGPP1,2 dephosphorylate sphingoid-1-phosphates IEA Dictyostelium discoideum DDB_G0272266 R-DDI-6800868 https://reactome.org/PathwayBrowser/#/R-DDI-6800868 NDUF subunits bind to form the IP subcomplex IEA Dictyostelium discoideum DDB_G0272296 R-DDI-203977 https://reactome.org/PathwayBrowser/#/R-DDI-203977 SAR1 Activation And Membrane Binding IEA Dictyostelium discoideum DDB_G0272296 R-DDI-203979 https://reactome.org/PathwayBrowser/#/R-DDI-203979 Coat Assembly IEA Dictyostelium discoideum DDB_G0272296 R-DDI-204008 https://reactome.org/PathwayBrowser/#/R-DDI-204008 SEC31:SEC13 and v-SNARE recruitment IEA Dictyostelium discoideum DDB_G0272296 R-DDI-5694522 https://reactome.org/PathwayBrowser/#/R-DDI-5694522 Inner coat assembly and cargo binding IEA Dictyostelium discoideum DDB_G0272296 R-DDI-5694527 https://reactome.org/PathwayBrowser/#/R-DDI-5694527 Loss of SAR1B GTPase IEA Dictyostelium discoideum DDB_G0272308 R-DDI-156823 https://reactome.org/PathwayBrowser/#/R-DDI-156823 Association of phospho-L13a with GAIT element of Ceruloplasmin mRNA IEA Dictyostelium discoideum DDB_G0272308 R-DDI-1799332 https://reactome.org/PathwayBrowser/#/R-DDI-1799332 Nascent polypeptide:mRNA:ribosome complex binds signal recognition particle (SRP) IEA Dictyostelium discoideum DDB_G0272308 R-DDI-72621 https://reactome.org/PathwayBrowser/#/R-DDI-72621 Ribosomal scanning IEA Dictyostelium discoideum DDB_G0272308 R-DDI-72671 https://reactome.org/PathwayBrowser/#/R-DDI-72671 eIF5B:GTP is hydrolyzed and released IEA Dictyostelium discoideum DDB_G0272308 R-DDI-72672 https://reactome.org/PathwayBrowser/#/R-DDI-72672 The 60S subunit joins the translation initiation complex IEA Dictyostelium discoideum DDB_G0272308 R-DDI-72673 https://reactome.org/PathwayBrowser/#/R-DDI-72673 Release of 40S and 60S subunits from the 80S ribosome IEA Dictyostelium discoideum DDB_G0272308 R-DDI-72676 https://reactome.org/PathwayBrowser/#/R-DDI-72676 eIF3 and eIF1A bind to the 40S subunit IEA Dictyostelium discoideum DDB_G0272308 R-DDI-72691 https://reactome.org/PathwayBrowser/#/R-DDI-72691 Formation of the 43S pre-initiation complex IEA Dictyostelium discoideum DDB_G0272308 R-DDI-72697 https://reactome.org/PathwayBrowser/#/R-DDI-72697 Start codon recognition IEA Dictyostelium discoideum DDB_G0272308 R-DDI-927789 https://reactome.org/PathwayBrowser/#/R-DDI-927789 Formation of UPF1:eRF3 complex on mRNA with a premature termination codon and no Exon Junction Complex IEA Dictyostelium discoideum DDB_G0272308 R-DDI-927832 https://reactome.org/PathwayBrowser/#/R-DDI-927832 UPF1 binds an mRNP with a termination codon preceding an Exon Junction Complex IEA Dictyostelium discoideum DDB_G0272308 R-DDI-927889 https://reactome.org/PathwayBrowser/#/R-DDI-927889 SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex) IEA Dictyostelium discoideum DDB_G0272318 R-DDI-9710959 https://reactome.org/PathwayBrowser/#/R-DDI-9710959 p-STAT1 dimer binds KPNA1 IEA Dictyostelium discoideum DDB_G0272320 R-DDI-111437 https://reactome.org/PathwayBrowser/#/R-DDI-111437 Cleavage of the 3'-end of the Histone Pre-mRNA IEA Dictyostelium discoideum DDB_G0272320 R-DDI-111438 https://reactome.org/PathwayBrowser/#/R-DDI-111438 Recruitment of U7 snRNP:ZFP100 complex to the Histone Pre-mRNA IEA Dictyostelium discoideum DDB_G0272320 R-DDI-77585 https://reactome.org/PathwayBrowser/#/R-DDI-77585 Recruitment of U7 snRNP:ZFP100 complex to the SLBP Bound Pre-mRNA IEA Dictyostelium discoideum DDB_G0272320 R-DDI-77586 https://reactome.org/PathwayBrowser/#/R-DDI-77586 Cleavage of the 3'-end of Replication Dependent Histone Pre-mRNA IEA Dictyostelium discoideum DDB_G0272320 R-DDI-9770236 https://reactome.org/PathwayBrowser/#/R-DDI-9770236 Formation of the Spliceosomal P complex and exon ligation IEA Dictyostelium discoideum DDB_G0272346 R-DDI-389652 https://reactome.org/PathwayBrowser/#/R-DDI-389652 PMP34-mediated exchange of cytosolic ATP for peroxisomal AMP IEA Dictyostelium discoideum DDB_G0272346 R-DDI-9603775 https://reactome.org/PathwayBrowser/#/R-DDI-9603775 PEX3:PEX19:class I PMP dissociates IEA Dictyostelium discoideum DDB_G0272346 R-DDI-9603784 https://reactome.org/PathwayBrowser/#/R-DDI-9603784 PEX19:class I PMP binds PEX3 IEA Dictyostelium discoideum DDB_G0272346 R-DDI-9603804 https://reactome.org/PathwayBrowser/#/R-DDI-9603804 PEX19 binds class I peroxisomal membrane proteins IEA Dictyostelium discoideum DDB_G0272350 R-DDI-5696074 https://reactome.org/PathwayBrowser/#/R-DDI-5696074 AGK:Mg2+ phosphorylates MAG, DAG IEA Dictyostelium discoideum DDB_G0272350 R-DDI-9695917 https://reactome.org/PathwayBrowser/#/R-DDI-9695917 SPHK2 binds SPHK2 inhibitors IEA Dictyostelium discoideum DDB_G0272350 R-DDI-9695949 https://reactome.org/PathwayBrowser/#/R-DDI-9695949 SPHK2 phosphorylates sphingoid IEA Dictyostelium discoideum DDB_G0272360 R-DDI-109636 https://reactome.org/PathwayBrowser/#/R-DDI-109636 Recognition and Binding of Core Promoter Elements by TFIID IEA Dictyostelium discoideum DDB_G0272360 R-DDI-109637 https://reactome.org/PathwayBrowser/#/R-DDI-109637 Binding of TFIIA and TFIIB to the pol II promoter:TFIID complex IEA Dictyostelium discoideum DDB_G0272360 R-DDI-109638 https://reactome.org/PathwayBrowser/#/R-DDI-109638 Recruitment of RNA Polymerase II Holoenzyme by TFIIF to the pol II promoter:TFIID:TFIIA:TFIIB complex IEA Dictyostelium discoideum DDB_G0272360 R-DDI-109639 https://reactome.org/PathwayBrowser/#/R-DDI-109639 Formation of the closed pre-initiation complex IEA Dictyostelium discoideum DDB_G0272360 R-DDI-5690080 https://reactome.org/PathwayBrowser/#/R-DDI-5690080 USP3,SAGA deubiquitinate Histone H2A,H2B IEA Dictyostelium discoideum DDB_G0272360 R-DDI-6810233 https://reactome.org/PathwayBrowser/#/R-DDI-6810233 CDK7 phosphorylates serine-5 and serine-7 of heptad repeats in C-terminal domain of RNA polymerase II at snRNA promoter IEA Dictyostelium discoideum DDB_G0272360 R-DDI-6810238 https://reactome.org/PathwayBrowser/#/R-DDI-6810238 RNA polymerase II binds initiation factors at promoter of snRNA gene (U1, U2, U4, U4atac, U5, U11, U12) IEA Dictyostelium discoideum DDB_G0272360 R-DDI-6814555 https://reactome.org/PathwayBrowser/#/R-DDI-6814555 Integrator complex processes the 3' end of snRNA IEA Dictyostelium discoideum DDB_G0272360 R-DDI-6814559 https://reactome.org/PathwayBrowser/#/R-DDI-6814559 Pre-snRNA is elongated and capped with 7-methylguanosine IEA Dictyostelium discoideum DDB_G0272360 R-DDI-73946 https://reactome.org/PathwayBrowser/#/R-DDI-73946 Abortive initiation after formation of the first phosphodiester bond IEA Dictyostelium discoideum DDB_G0272360 R-DDI-75095 https://reactome.org/PathwayBrowser/#/R-DDI-75095 Binding of TFIIE to the growing preinitiation complex IEA Dictyostelium discoideum DDB_G0272360 R-DDI-75850 https://reactome.org/PathwayBrowser/#/R-DDI-75850 Addition of the third nucleotide on the nascent transcript IEA Dictyostelium discoideum DDB_G0272360 R-DDI-75856 https://reactome.org/PathwayBrowser/#/R-DDI-75856 Abortive Initiation Before Second Transition IEA Dictyostelium discoideum DDB_G0272360 R-DDI-75861 https://reactome.org/PathwayBrowser/#/R-DDI-75861 NTP Binds Active Site of RNA Polymerase II IEA Dictyostelium discoideum DDB_G0272360 R-DDI-75862 https://reactome.org/PathwayBrowser/#/R-DDI-75862 Fall Back to Closed Pre-initiation Complex IEA Dictyostelium discoideum DDB_G0272360 R-DDI-75864 https://reactome.org/PathwayBrowser/#/R-DDI-75864 Newly Formed Phosphodiester Bond Stabilized and PPi Released IEA Dictyostelium discoideum DDB_G0272360 R-DDI-75866 https://reactome.org/PathwayBrowser/#/R-DDI-75866 Nucleophillic Attack by 3'-hydroxyl Oxygen of nascent transcript on the Alpha Phosphate of NTP IEA Dictyostelium discoideum DDB_G0272360 R-DDI-75869 https://reactome.org/PathwayBrowser/#/R-DDI-75869 Addition of the fourth nucleotide on the Nascent Transcript: Second Transition IEA Dictyostelium discoideum DDB_G0272360 R-DDI-75873 https://reactome.org/PathwayBrowser/#/R-DDI-75873 Addition of Nucleotides 5 through 9 on the growing Transcript IEA Dictyostelium discoideum DDB_G0272360 R-DDI-75949 https://reactome.org/PathwayBrowser/#/R-DDI-75949 RNA Polymerase II Promoter Opening: First Transition IEA Dictyostelium discoideum DDB_G0272360 R-DDI-9613494 https://reactome.org/PathwayBrowser/#/R-DDI-9613494 Unwinding of DNA for the Nascent Transcript: Second Transition IEA Dictyostelium discoideum DDB_G0272360 R-DDI-9613497 https://reactome.org/PathwayBrowser/#/R-DDI-9613497 Unwinding DNA for the nascent transcript IEA Dictyostelium discoideum DDB_G0272362 R-DDI-109639 https://reactome.org/PathwayBrowser/#/R-DDI-109639 Formation of the closed pre-initiation complex IEA Dictyostelium discoideum DDB_G0272362 R-DDI-111264 https://reactome.org/PathwayBrowser/#/R-DDI-111264 Addition of nucleotides between position +11 and +30 IEA Dictyostelium discoideum DDB_G0272362 R-DDI-112383 https://reactome.org/PathwayBrowser/#/R-DDI-112383 Hypophosphorylation of RNA Pol II CTD by FCP1P protein IEA Dictyostelium discoideum DDB_G0272362 R-DDI-113430 https://reactome.org/PathwayBrowser/#/R-DDI-113430 Extrusion of 5'-end of 30 nt long transcript through the pore in Pol II complex IEA Dictyostelium discoideum DDB_G0272362 R-DDI-5690996 https://reactome.org/PathwayBrowser/#/R-DDI-5690996 ERCC2 and ERCC3 DNA helicases form an open bubble structure in damaged DNA IEA Dictyostelium discoideum DDB_G0272362 R-DDI-5691000 https://reactome.org/PathwayBrowser/#/R-DDI-5691000 TFIIH binds GG-NER site to form a verification complex IEA Dictyostelium discoideum DDB_G0272362 R-DDI-6781818 https://reactome.org/PathwayBrowser/#/R-DDI-6781818 RNA Pol II initiates transcription from damaged DNA template IEA Dictyostelium discoideum DDB_G0272362 R-DDI-6781824 https://reactome.org/PathwayBrowser/#/R-DDI-6781824 Active RNA Pol II complex transcribes lesion-containing DNA template IEA Dictyostelium discoideum DDB_G0272362 R-DDI-6781833 https://reactome.org/PathwayBrowser/#/R-DDI-6781833 ERCC8 (CSA) binds stalled RNA Pol II IEA Dictyostelium discoideum DDB_G0272362 R-DDI-6781840 https://reactome.org/PathwayBrowser/#/R-DDI-6781840 ERCC6 binds stalled RNA Pol II IEA Dictyostelium discoideum DDB_G0272362 R-DDI-6781867 https://reactome.org/PathwayBrowser/#/R-DDI-6781867 ERCC8:DDB1:CUL4:RBX1 ubiquitinates ERCC6 and RNA Pol II IEA Dictyostelium discoideum DDB_G0272362 R-DDI-6782069 https://reactome.org/PathwayBrowser/#/R-DDI-6782069 UVSSA:USP7 deubiquitinates ERCC6 IEA Dictyostelium discoideum DDB_G0272362 R-DDI-6782131 https://reactome.org/PathwayBrowser/#/R-DDI-6782131 ERCC2-facilitated RNA Pol II backtracking in TC-NER IEA Dictyostelium discoideum DDB_G0272362 R-DDI-6782141 https://reactome.org/PathwayBrowser/#/R-DDI-6782141 Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in TC-NER IEA Dictyostelium discoideum DDB_G0272362 R-DDI-6782204 https://reactome.org/PathwayBrowser/#/R-DDI-6782204 5' incision of damaged DNA strand by ERCC1:ERCC4 in TC-NER IEA Dictyostelium discoideum DDB_G0272362 R-DDI-6782208 https://reactome.org/PathwayBrowser/#/R-DDI-6782208 Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in TC-NER IEA Dictyostelium discoideum DDB_G0272362 R-DDI-6782211 https://reactome.org/PathwayBrowser/#/R-DDI-6782211 DNA polymerases delta, epsilon or kappa bind the TC-NER site IEA Dictyostelium discoideum DDB_G0272362 R-DDI-6782227 https://reactome.org/PathwayBrowser/#/R-DDI-6782227 Ligation of newly synthesized repair patch to incised DNA in TC-NER IEA Dictyostelium discoideum DDB_G0272362 R-DDI-6797606 https://reactome.org/PathwayBrowser/#/R-DDI-6797606 CDK12 phosphorylates RNA Pol II CTD at DNA repair genes IEA Dictyostelium discoideum DDB_G0272362 R-DDI-6797616 https://reactome.org/PathwayBrowser/#/R-DDI-6797616 CCNK:CDK12 binds RNA Pol II at DNA repair genes IEA Dictyostelium discoideum DDB_G0272362 R-DDI-73769 https://reactome.org/PathwayBrowser/#/R-DDI-73769 Loss of Rrn3 from RNA Polymerase I promoter escape complex IEA Dictyostelium discoideum DDB_G0272362 R-DDI-73946 https://reactome.org/PathwayBrowser/#/R-DDI-73946 Abortive initiation after formation of the first phosphodiester bond IEA Dictyostelium discoideum DDB_G0272362 R-DDI-74986 https://reactome.org/PathwayBrowser/#/R-DDI-74986 Elongation of pre-rRNA transcript IEA Dictyostelium discoideum DDB_G0272362 R-DDI-75850 https://reactome.org/PathwayBrowser/#/R-DDI-75850 Addition of the third nucleotide on the nascent transcript IEA Dictyostelium discoideum DDB_G0272362 R-DDI-75856 https://reactome.org/PathwayBrowser/#/R-DDI-75856 Abortive Initiation Before Second Transition IEA Dictyostelium discoideum DDB_G0272362 R-DDI-75861 https://reactome.org/PathwayBrowser/#/R-DDI-75861 NTP Binds Active Site of RNA Polymerase II IEA Dictyostelium discoideum DDB_G0272362 R-DDI-75862 https://reactome.org/PathwayBrowser/#/R-DDI-75862 Fall Back to Closed Pre-initiation Complex IEA Dictyostelium discoideum DDB_G0272362 R-DDI-75864 https://reactome.org/PathwayBrowser/#/R-DDI-75864 Newly Formed Phosphodiester Bond Stabilized and PPi Released IEA Dictyostelium discoideum DDB_G0272362 R-DDI-75866 https://reactome.org/PathwayBrowser/#/R-DDI-75866 Nucleophillic Attack by 3'-hydroxyl Oxygen of nascent transcript on the Alpha Phosphate of NTP IEA Dictyostelium discoideum DDB_G0272362 R-DDI-75869 https://reactome.org/PathwayBrowser/#/R-DDI-75869 Addition of the fourth nucleotide on the Nascent Transcript: Second Transition IEA Dictyostelium discoideum DDB_G0272362 R-DDI-75873 https://reactome.org/PathwayBrowser/#/R-DDI-75873 Addition of Nucleotides 5 through 9 on the growing Transcript IEA Dictyostelium discoideum DDB_G0272362 R-DDI-75891 https://reactome.org/PathwayBrowser/#/R-DDI-75891 Abortive Initiation After Second Transition IEA Dictyostelium discoideum DDB_G0272362 R-DDI-75949 https://reactome.org/PathwayBrowser/#/R-DDI-75949 RNA Polymerase II Promoter Opening: First Transition IEA Dictyostelium discoideum DDB_G0272362 R-DDI-76576 https://reactome.org/PathwayBrowser/#/R-DDI-76576 Addition of nucleotides 10 and 11 on the growing transcript: Third Transition IEA Dictyostelium discoideum DDB_G0272362 R-DDI-77068 https://reactome.org/PathwayBrowser/#/R-DDI-77068 Activation of GT IEA Dictyostelium discoideum DDB_G0272362 R-DDI-77069 https://reactome.org/PathwayBrowser/#/R-DDI-77069 RNA Polymerase II CTD (phosphorylated) binds to CE IEA Dictyostelium discoideum DDB_G0272362 R-DDI-77071 https://reactome.org/PathwayBrowser/#/R-DDI-77071 Phosphorylation (Ser5) of RNA pol II CTD IEA Dictyostelium discoideum DDB_G0272362 R-DDI-77073 https://reactome.org/PathwayBrowser/#/R-DDI-77073 SPT5 subunit of Pol II binds the RNA triphosphatase (RTP) IEA Dictyostelium discoideum DDB_G0272362 R-DDI-77077 https://reactome.org/PathwayBrowser/#/R-DDI-77077 Capping complex formation IEA Dictyostelium discoideum DDB_G0272362 R-DDI-77078 https://reactome.org/PathwayBrowser/#/R-DDI-77078 Hydrolysis of the 5'-end of the nascent transcript by the capping enzyme IEA Dictyostelium discoideum DDB_G0272362 R-DDI-77081 https://reactome.org/PathwayBrowser/#/R-DDI-77081 Formation of the CE:GMP intermediate complex IEA Dictyostelium discoideum DDB_G0272362 R-DDI-77083 https://reactome.org/PathwayBrowser/#/R-DDI-77083 Transfer of GMP from the capping enzyme GT site to 5'-end of mRNA IEA Dictyostelium discoideum DDB_G0272362 R-DDI-77085 https://reactome.org/PathwayBrowser/#/R-DDI-77085 Dissociation of transcript with 5'-GMP from GT IEA Dictyostelium discoideum DDB_G0272362 R-DDI-77090 https://reactome.org/PathwayBrowser/#/R-DDI-77090 Methylation of GMP-cap by RNA Methyltransferase IEA Dictyostelium discoideum DDB_G0272362 R-DDI-9613494 https://reactome.org/PathwayBrowser/#/R-DDI-9613494 Unwinding of DNA for the Nascent Transcript: Second Transition IEA Dictyostelium discoideum DDB_G0272362 R-DDI-9613497 https://reactome.org/PathwayBrowser/#/R-DDI-9613497 Unwinding DNA for the nascent transcript IEA Dictyostelium discoideum DDB_G0272362 R-DDI-9684118 https://reactome.org/PathwayBrowser/#/R-DDI-9684118 ERCC3-facilitated RNA Pol II backtracking in TC-NER IEA Dictyostelium discoideum DDB_G0272372 R-DDI-205039 https://reactome.org/PathwayBrowser/#/R-DDI-205039 p75NTR indirectly activates RAC and Cdc42 via a guanyl-nucleotide exchange factor IEA Dictyostelium discoideum DDB_G0272372 R-DDI-9013143 https://reactome.org/PathwayBrowser/#/R-DDI-9013143 RAC1 GEFs activate RAC1 IEA Dictyostelium discoideum DDB_G0272372 R-DDI-9013159 https://reactome.org/PathwayBrowser/#/R-DDI-9013159 CDC42 GEFs activate CDC42 IEA Dictyostelium discoideum DDB_G0272372 R-DDI-9018747 https://reactome.org/PathwayBrowser/#/R-DDI-9018747 RHOQ GEFs activate RHOQ IEA Dictyostelium discoideum DDB_G0272434 R-DDI-2328033 https://reactome.org/PathwayBrowser/#/R-DDI-2328033 Fibrillin-1 binds latent TGF-beta IEA Dictyostelium discoideum DDB_G0272434 R-DDI-6798743 https://reactome.org/PathwayBrowser/#/R-DDI-6798743 Exocytosis of secretory granule membrane proteins IEA Dictyostelium discoideum DDB_G0272434 R-DDI-6798747 https://reactome.org/PathwayBrowser/#/R-DDI-6798747 Exocytosis of tertiary granule membrane proteins IEA Dictyostelium discoideum DDB_G0272434 R-DDI-6799350 https://reactome.org/PathwayBrowser/#/R-DDI-6799350 Exocytosis of specific granule membrane proteins IEA Dictyostelium discoideum DDB_G0272434 R-DDI-6800426 https://reactome.org/PathwayBrowser/#/R-DDI-6800426 Exocytosis of ficolin-rich granule membrane proteins IEA Dictyostelium discoideum DDB_G0272440 R-DDI-6799466 https://reactome.org/PathwayBrowser/#/R-DDI-6799466 TP53I3 dimerizes IEA Dictyostelium discoideum DDB_G0272440 R-DDI-6799722 https://reactome.org/PathwayBrowser/#/R-DDI-6799722 TP53I3 oxidoreductase generates unstable semiquinones IEA Dictyostelium discoideum DDB_G0272462 R-DDI-197268 https://reactome.org/PathwayBrowser/#/R-DDI-197268 QPRT transfers PRIB to QUIN to form NAMN IEA Dictyostelium discoideum DDB_G0272468 R-DDI-427998 https://reactome.org/PathwayBrowser/#/R-DDI-427998 SLC25A1 transports di-/tri-peptides and peptide-like drugs IEA Dictyostelium discoideum DDB_G0272470 R-DDI-927832 https://reactome.org/PathwayBrowser/#/R-DDI-927832 UPF1 binds an mRNP with a termination codon preceding an Exon Junction Complex IEA Dictyostelium discoideum DDB_G0272470 R-DDI-927889 https://reactome.org/PathwayBrowser/#/R-DDI-927889 SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex) IEA Dictyostelium discoideum DDB_G0272476 R-DDI-9837978 https://reactome.org/PathwayBrowser/#/R-DDI-9837978 LONP1 binds mitochondrial inner membrane proteins IEA Dictyostelium discoideum DDB_G0272476 R-DDI-9838004 https://reactome.org/PathwayBrowser/#/R-DDI-9838004 LONP1 degrades mitochondrial inner membrane proteins IEA Dictyostelium discoideum DDB_G0272484 R-DDI-8866601 https://reactome.org/PathwayBrowser/#/R-DDI-8866601 SAMHD1:Zn2+ tetramer hydrolyzes dNTP to nucleoside and triphosphate IEA Dictyostelium discoideum DDB_G0272486 R-DDI-8847880 https://reactome.org/PathwayBrowser/#/R-DDI-8847880 CYTH proteins bind ARF1:GTP IEA Dictyostelium discoideum DDB_G0272486 R-DDI-8847883 https://reactome.org/PathwayBrowser/#/R-DDI-8847883 CYTH proteins stimulate ARF1 GTPase activity IEA Dictyostelium discoideum DDB_G0272498 R-DDI-8867667 https://reactome.org/PathwayBrowser/#/R-DDI-8867667 OSBPs transport 25OH-CHOL from ER membrane to plasma membrane IEA Dictyostelium discoideum DDB_G0272498 R-DDI-8867876 https://reactome.org/PathwayBrowser/#/R-DDI-8867876 OSBPL5,8,10 exchange PS with PI4P from ER membrane to plasma membrane IEA Dictyostelium discoideum DDB_G0272498 R-DDI-9018758 https://reactome.org/PathwayBrowser/#/R-DDI-9018758 RHOH binds effectors at the plasma membrane IEA Dictyostelium discoideum DDB_G0272522 R-DDI-391266 https://reactome.org/PathwayBrowser/#/R-DDI-391266 Association of CCT/TriC with sphingosine kinase 1 IEA Dictyostelium discoideum DDB_G0272522 R-DDI-428273 https://reactome.org/PathwayBrowser/#/R-DDI-428273 SPHK1 phosphorylates sphingoid IEA Dictyostelium discoideum DDB_G0272522 R-DDI-5218823 https://reactome.org/PathwayBrowser/#/R-DDI-5218823 PKC phosphorylates sphingosine kinase 1 IEA Dictyostelium discoideum DDB_G0272522 R-DDI-5696074 https://reactome.org/PathwayBrowser/#/R-DDI-5696074 AGK:Mg2+ phosphorylates MAG, DAG IEA Dictyostelium discoideum DDB_G0272522 R-DDI-9625814 https://reactome.org/PathwayBrowser/#/R-DDI-9625814 SPHK1 phosphorylates sphingosine in response to E2 stimulation IEA Dictyostelium discoideum DDB_G0272522 R-DDI-9695917 https://reactome.org/PathwayBrowser/#/R-DDI-9695917 SPHK2 binds SPHK2 inhibitors IEA Dictyostelium discoideum DDB_G0272522 R-DDI-9695949 https://reactome.org/PathwayBrowser/#/R-DDI-9695949 SPHK2 phosphorylates sphingoid IEA Dictyostelium discoideum DDB_G0272522 R-DDI-9836621 https://reactome.org/PathwayBrowser/#/R-DDI-9836621 p-S225-SPHK1 localizes to cytosol IEA Dictyostelium discoideum DDB_G0272542 R-DDI-163664 https://reactome.org/PathwayBrowser/#/R-DDI-163664 AMP binds to gamma subunit of AMP kinase heterotrimer IEA Dictyostelium discoideum DDB_G0272542 R-DDI-200423 https://reactome.org/PathwayBrowser/#/R-DDI-200423 pAMPK inactivates ACACB, inhibiting malonyl-CoA synthesis IEA Dictyostelium discoideum DDB_G0272542 R-DDI-380930 https://reactome.org/PathwayBrowser/#/R-DDI-380930 Phosphorylated AMPK binds AMP IEA Dictyostelium discoideum DDB_G0272542 R-DDI-447074 https://reactome.org/PathwayBrowser/#/R-DDI-447074 AMPK phosphorylates Raptor in the mTORC1 complex IEA Dictyostelium discoideum DDB_G0272542 R-DDI-5631941 https://reactome.org/PathwayBrowser/#/R-DDI-5631941 SESN1,2,3 bind AMPK IEA Dictyostelium discoideum DDB_G0272542 R-DDI-5665868 https://reactome.org/PathwayBrowser/#/R-DDI-5665868 AMPK (complex) phosphorylates ULK1 (complex) IEA Dictyostelium discoideum DDB_G0272542 R-DDI-5672008 https://reactome.org/PathwayBrowser/#/R-DDI-5672008 Thr-180 of ULK1 is phosphorylated IEA Dictyostelium discoideum DDB_G0272542 R-DDI-5672011 https://reactome.org/PathwayBrowser/#/R-DDI-5672011 p-AMPK:AMP binds the ULK complex IEA Dictyostelium discoideum DDB_G0272542 R-DDI-5673768 https://reactome.org/PathwayBrowser/#/R-DDI-5673768 p-AMPK:AMP phosphorylates Raptor in the MTORC1 complex IEA Dictyostelium discoideum DDB_G0272542 R-DDI-5675868 https://reactome.org/PathwayBrowser/#/R-DDI-5675868 ULK1 phosphorylates ATG13 and RB1CC1 IEA Dictyostelium discoideum DDB_G0272542 R-DDI-5679205 https://reactome.org/PathwayBrowser/#/R-DDI-5679205 ULK1 phosphorylates Beclin-1 IEA Dictyostelium discoideum DDB_G0272542 R-DDI-5679239 https://reactome.org/PathwayBrowser/#/R-DDI-5679239 ULK complex translocates to the ER IEA Dictyostelium discoideum DDB_G0272544 R-DDI-199626 https://reactome.org/PathwayBrowser/#/R-DDI-199626 SLC19A2/3 transport extracellular THMN to cytosol IEA Dictyostelium discoideum DDB_G0272544 R-DDI-200652 https://reactome.org/PathwayBrowser/#/R-DDI-200652 SLC19A1 transports 5-methyl-THF from extracellular region to cytosol IEA Dictyostelium discoideum DDB_G0272550 R-DDI-427998 https://reactome.org/PathwayBrowser/#/R-DDI-427998 SLC25A1 transports di-/tri-peptides and peptide-like drugs IEA Dictyostelium discoideum DDB_G0272564 R-DDI-1236970 https://reactome.org/PathwayBrowser/#/R-DDI-1236970 Proteasomal clevage of exogenous antigen (26S proteasome catalyst) IEA Dictyostelium discoideum DDB_G0272564 R-DDI-1504193 https://reactome.org/PathwayBrowser/#/R-DDI-1504193 Ubiquitinated DVL is degraded by the proteasome IEA Dictyostelium discoideum DDB_G0272564 R-DDI-174058 https://reactome.org/PathwayBrowser/#/R-DDI-174058 Degradation of multiubiquitinated Cdh1 IEA Dictyostelium discoideum DDB_G0272564 R-DDI-174105 https://reactome.org/PathwayBrowser/#/R-DDI-174105 Degradation of multiubiquitinated cell cycle proteins IEA Dictyostelium discoideum DDB_G0272564 R-DDI-174202 https://reactome.org/PathwayBrowser/#/R-DDI-174202 Degradation of multiubiquitinated Securin IEA Dictyostelium discoideum DDB_G0272564 R-DDI-188191 https://reactome.org/PathwayBrowser/#/R-DDI-188191 APC/C:Cdh1-mediated degradation of Skp2 IEA Dictyostelium discoideum DDB_G0272564 R-DDI-264458 https://reactome.org/PathwayBrowser/#/R-DDI-264458 Proteasome mediated degradation of COP1 IEA Dictyostelium discoideum DDB_G0272564 R-DDI-450466 https://reactome.org/PathwayBrowser/#/R-DDI-450466 AUF1:mRNA complex is destroyed IEA Dictyostelium discoideum DDB_G0272564 R-DDI-5635854 https://reactome.org/PathwayBrowser/#/R-DDI-5635854 GLI2,3 are degraded by the proteasome IEA Dictyostelium discoideum DDB_G0272564 R-DDI-5658430 https://reactome.org/PathwayBrowser/#/R-DDI-5658430 NF1 is degraded by the proteasome IEA Dictyostelium discoideum DDB_G0272564 R-DDI-5665854 https://reactome.org/PathwayBrowser/#/R-DDI-5665854 ADRM1:26S proteaseome binds UCHL5 IEA Dictyostelium discoideum DDB_G0272564 R-DDI-5665871 https://reactome.org/PathwayBrowser/#/R-DDI-5665871 ADRM1 binds 26S proteasome IEA Dictyostelium discoideum DDB_G0272564 R-DDI-5687112 https://reactome.org/PathwayBrowser/#/R-DDI-5687112 MAPK6 is degraded by the 26S proteasome IEA Dictyostelium discoideum DDB_G0272564 R-DDI-5689539 https://reactome.org/PathwayBrowser/#/R-DDI-5689539 ADRM1:26S proteaseome binds USP14 IEA Dictyostelium discoideum DDB_G0272564 R-DDI-68948 https://reactome.org/PathwayBrowser/#/R-DDI-68948 Ubiquitinated Orc1 is degraded by the proteasome IEA Dictyostelium discoideum DDB_G0272564 R-DDI-69016 https://reactome.org/PathwayBrowser/#/R-DDI-69016 Ubiquitinated Cdc6 is degraded by the proteasome IEA Dictyostelium discoideum DDB_G0272564 R-DDI-69600 https://reactome.org/PathwayBrowser/#/R-DDI-69600 Proteolytic degradation of ubiquitinated-Cdc25A IEA Dictyostelium discoideum DDB_G0272564 R-DDI-8850992 https://reactome.org/PathwayBrowser/#/R-DDI-8850992 Proteasome degrades polyubiquitinated PTEN IEA Dictyostelium discoideum DDB_G0272564 R-DDI-8854044 https://reactome.org/PathwayBrowser/#/R-DDI-8854044 Proteasome degrades AURKA ubiquitinated by SCF-FBXL7 IEA Dictyostelium discoideum DDB_G0272564 R-DDI-8866553 https://reactome.org/PathwayBrowser/#/R-DDI-8866553 misfolded CFTR is degraded by the 26S proteasome IEA Dictyostelium discoideum DDB_G0272564 R-DDI-9755306 https://reactome.org/PathwayBrowser/#/R-DDI-9755306 ub UBXN7 is degraded by the 26S proteasome IEA Dictyostelium discoideum DDB_G0272564 R-DDI-983150 https://reactome.org/PathwayBrowser/#/R-DDI-983150 Proteasomal cleavage of substrate IEA Dictyostelium discoideum DDB_G0272564 R-DDI-9908019 https://reactome.org/PathwayBrowser/#/R-DDI-9908019 Formation of the 19S regulatory particle lid IEA Dictyostelium discoideum DDB_G0272564 R-DDI-9908026 https://reactome.org/PathwayBrowser/#/R-DDI-9908026 Formation of the 19S regulatory particle precursor IEA Dictyostelium discoideum DDB_G0272564 R-DDI-9908178 https://reactome.org/PathwayBrowser/#/R-DDI-9908178 Formation of the 26S proteasome IEA Dictyostelium discoideum DDB_G0272566 R-DDI-1236970 https://reactome.org/PathwayBrowser/#/R-DDI-1236970 Proteasomal clevage of exogenous antigen (26S proteasome catalyst) IEA Dictyostelium discoideum DDB_G0272566 R-DDI-1504193 https://reactome.org/PathwayBrowser/#/R-DDI-1504193 Ubiquitinated DVL is degraded by the proteasome IEA Dictyostelium discoideum DDB_G0272566 R-DDI-174058 https://reactome.org/PathwayBrowser/#/R-DDI-174058 Degradation of multiubiquitinated Cdh1 IEA Dictyostelium discoideum DDB_G0272566 R-DDI-174105 https://reactome.org/PathwayBrowser/#/R-DDI-174105 Degradation of multiubiquitinated cell cycle proteins IEA Dictyostelium discoideum DDB_G0272566 R-DDI-174202 https://reactome.org/PathwayBrowser/#/R-DDI-174202 Degradation of multiubiquitinated Securin IEA Dictyostelium discoideum DDB_G0272566 R-DDI-188191 https://reactome.org/PathwayBrowser/#/R-DDI-188191 APC/C:Cdh1-mediated degradation of Skp2 IEA Dictyostelium discoideum DDB_G0272566 R-DDI-264458 https://reactome.org/PathwayBrowser/#/R-DDI-264458 Proteasome mediated degradation of COP1 IEA Dictyostelium discoideum DDB_G0272566 R-DDI-450466 https://reactome.org/PathwayBrowser/#/R-DDI-450466 AUF1:mRNA complex is destroyed IEA Dictyostelium discoideum DDB_G0272566 R-DDI-5635854 https://reactome.org/PathwayBrowser/#/R-DDI-5635854 GLI2,3 are degraded by the proteasome IEA Dictyostelium discoideum DDB_G0272566 R-DDI-5658430 https://reactome.org/PathwayBrowser/#/R-DDI-5658430 NF1 is degraded by the proteasome IEA Dictyostelium discoideum DDB_G0272566 R-DDI-5665854 https://reactome.org/PathwayBrowser/#/R-DDI-5665854 ADRM1:26S proteaseome binds UCHL5 IEA Dictyostelium discoideum DDB_G0272566 R-DDI-5665871 https://reactome.org/PathwayBrowser/#/R-DDI-5665871 ADRM1 binds 26S proteasome IEA Dictyostelium discoideum DDB_G0272566 R-DDI-5687112 https://reactome.org/PathwayBrowser/#/R-DDI-5687112 MAPK6 is degraded by the 26S proteasome IEA Dictyostelium discoideum DDB_G0272566 R-DDI-5689539 https://reactome.org/PathwayBrowser/#/R-DDI-5689539 ADRM1:26S proteaseome binds USP14 IEA Dictyostelium discoideum DDB_G0272566 R-DDI-5691431 https://reactome.org/PathwayBrowser/#/R-DDI-5691431 PSMD14 cleaves K63-linked ubiquitin IEA Dictyostelium discoideum DDB_G0272566 R-DDI-6798748 https://reactome.org/PathwayBrowser/#/R-DDI-6798748 Exocytosis of secretory granule lumen proteins IEA Dictyostelium discoideum DDB_G0272566 R-DDI-6800434 https://reactome.org/PathwayBrowser/#/R-DDI-6800434 Exocytosis of ficolin-rich granule lumen proteins IEA Dictyostelium discoideum DDB_G0272566 R-DDI-68948 https://reactome.org/PathwayBrowser/#/R-DDI-68948 Ubiquitinated Orc1 is degraded by the proteasome IEA Dictyostelium discoideum DDB_G0272566 R-DDI-69016 https://reactome.org/PathwayBrowser/#/R-DDI-69016 Ubiquitinated Cdc6 is degraded by the proteasome IEA Dictyostelium discoideum DDB_G0272566 R-DDI-69600 https://reactome.org/PathwayBrowser/#/R-DDI-69600 Proteolytic degradation of ubiquitinated-Cdc25A IEA Dictyostelium discoideum DDB_G0272566 R-DDI-8850992 https://reactome.org/PathwayBrowser/#/R-DDI-8850992 Proteasome degrades polyubiquitinated PTEN IEA Dictyostelium discoideum DDB_G0272566 R-DDI-8854044 https://reactome.org/PathwayBrowser/#/R-DDI-8854044 Proteasome degrades AURKA ubiquitinated by SCF-FBXL7 IEA Dictyostelium discoideum DDB_G0272566 R-DDI-8866553 https://reactome.org/PathwayBrowser/#/R-DDI-8866553 misfolded CFTR is degraded by the 26S proteasome IEA Dictyostelium discoideum DDB_G0272566 R-DDI-9755306 https://reactome.org/PathwayBrowser/#/R-DDI-9755306 ub UBXN7 is degraded by the 26S proteasome IEA Dictyostelium discoideum DDB_G0272566 R-DDI-983150 https://reactome.org/PathwayBrowser/#/R-DDI-983150 Proteasomal cleavage of substrate IEA Dictyostelium discoideum DDB_G0272566 R-DDI-9907992 https://reactome.org/PathwayBrowser/#/R-DDI-9907992 PSMD11 binds PSMD7:PSMD12:PSMD13:PSMD14 IEA Dictyostelium discoideum DDB_G0272566 R-DDI-9907998 https://reactome.org/PathwayBrowser/#/R-DDI-9907998 Formation of the complex of PSMD7, PSMD12, PSMD13, and PSMD14 IEA Dictyostelium discoideum DDB_G0272566 R-DDI-9908019 https://reactome.org/PathwayBrowser/#/R-DDI-9908019 Formation of the 19S regulatory particle lid IEA Dictyostelium discoideum DDB_G0272566 R-DDI-9908026 https://reactome.org/PathwayBrowser/#/R-DDI-9908026 Formation of the 19S regulatory particle precursor IEA Dictyostelium discoideum DDB_G0272566 R-DDI-9908178 https://reactome.org/PathwayBrowser/#/R-DDI-9908178 Formation of the 26S proteasome IEA Dictyostelium discoideum DDB_G0272580 R-DDI-9629578 https://reactome.org/PathwayBrowser/#/R-DDI-9629578 JMJD7 dimer hydroxlates a lysine residue of DRG2 IEA Dictyostelium discoideum DDB_G0272582 R-DDI-141186 https://reactome.org/PathwayBrowser/#/R-DDI-141186 MAOA:FAD oxidatively deaminates of 5HT IEA Dictyostelium discoideum DDB_G0272582 R-DDI-141200 https://reactome.org/PathwayBrowser/#/R-DDI-141200 MAOB:FAD oxidatively deaminates of PEA IEA Dictyostelium discoideum DDB_G0272582 R-DDI-141202 https://reactome.org/PathwayBrowser/#/R-DDI-141202 MAOB:FAD oxidatively deaminates TYR IEA Dictyostelium discoideum DDB_G0272582 R-DDI-374909 https://reactome.org/PathwayBrowser/#/R-DDI-374909 Catabolism of Noradrenaline IEA Dictyostelium discoideum DDB_G0272582 R-DDI-379382 https://reactome.org/PathwayBrowser/#/R-DDI-379382 MAOA:FAD deaminates DA to DOPAC IEA Dictyostelium discoideum DDB_G0272582 R-DDI-379395 https://reactome.org/PathwayBrowser/#/R-DDI-379395 MAOA:FAD deaminates 3MT to HVA IEA Dictyostelium discoideum DDB_G0272582 R-DDI-9677917 https://reactome.org/PathwayBrowser/#/R-DDI-9677917 MAOA inhibitors bind MAOA:FAD IEA Dictyostelium discoideum DDB_G0272582 R-DDI-9677929 https://reactome.org/PathwayBrowser/#/R-DDI-9677929 MAOB inhibitors bind MAOB:FAD IEA Dictyostelium discoideum DDB_G0272584 R-DDI-141186 https://reactome.org/PathwayBrowser/#/R-DDI-141186 MAOA:FAD oxidatively deaminates of 5HT IEA Dictyostelium discoideum DDB_G0272584 R-DDI-141200 https://reactome.org/PathwayBrowser/#/R-DDI-141200 MAOB:FAD oxidatively deaminates of PEA IEA Dictyostelium discoideum DDB_G0272584 R-DDI-141202 https://reactome.org/PathwayBrowser/#/R-DDI-141202 MAOB:FAD oxidatively deaminates TYR IEA Dictyostelium discoideum DDB_G0272584 R-DDI-374909 https://reactome.org/PathwayBrowser/#/R-DDI-374909 Catabolism of Noradrenaline IEA Dictyostelium discoideum DDB_G0272584 R-DDI-379382 https://reactome.org/PathwayBrowser/#/R-DDI-379382 MAOA:FAD deaminates DA to DOPAC IEA Dictyostelium discoideum DDB_G0272584 R-DDI-379395 https://reactome.org/PathwayBrowser/#/R-DDI-379395 MAOA:FAD deaminates 3MT to HVA IEA Dictyostelium discoideum DDB_G0272584 R-DDI-9677917 https://reactome.org/PathwayBrowser/#/R-DDI-9677917 MAOA inhibitors bind MAOA:FAD IEA Dictyostelium discoideum DDB_G0272584 R-DDI-9677929 https://reactome.org/PathwayBrowser/#/R-DDI-9677929 MAOB inhibitors bind MAOB:FAD IEA Dictyostelium discoideum DDB_G0272590 R-DDI-1799332 https://reactome.org/PathwayBrowser/#/R-DDI-1799332 Nascent polypeptide:mRNA:ribosome complex binds signal recognition particle (SRP) IEA Dictyostelium discoideum DDB_G0272590 R-DDI-6798748 https://reactome.org/PathwayBrowser/#/R-DDI-6798748 Exocytosis of secretory granule lumen proteins IEA Dictyostelium discoideum DDB_G0272590 R-DDI-6800434 https://reactome.org/PathwayBrowser/#/R-DDI-6800434 Exocytosis of ficolin-rich granule lumen proteins IEA Dictyostelium discoideum DDB_G0272604 R-DDI-143468 https://reactome.org/PathwayBrowser/#/R-DDI-143468 MEOS oxidizes ethanol to acetaldehyde IEA Dictyostelium discoideum DDB_G0272604 R-DDI-156526 https://reactome.org/PathwayBrowser/#/R-DDI-156526 CYP1A2,3A4,3A5,2A13 oxidise AFB1 to AFXBO IEA Dictyostelium discoideum DDB_G0272604 R-DDI-211874 https://reactome.org/PathwayBrowser/#/R-DDI-211874 CYP2S1 4-hydroxylates atRA IEA Dictyostelium discoideum DDB_G0272604 R-DDI-211881 https://reactome.org/PathwayBrowser/#/R-DDI-211881 Coumarin is 7-hydroxylated by CYP2A13 IEA Dictyostelium discoideum DDB_G0272604 R-DDI-211910 https://reactome.org/PathwayBrowser/#/R-DDI-211910 CYP2C8 inactivates paclitaxel by 6alpha-hydroxylation IEA Dictyostelium discoideum DDB_G0272604 R-DDI-211929 https://reactome.org/PathwayBrowser/#/R-DDI-211929 CYP2C19 5-hydroxylates omeprazole IEA Dictyostelium discoideum DDB_G0272604 R-DDI-211960 https://reactome.org/PathwayBrowser/#/R-DDI-211960 CYP2U1 19-hydroxylates ARA IEA Dictyostelium discoideum DDB_G0272604 R-DDI-211966 https://reactome.org/PathwayBrowser/#/R-DDI-211966 CYP2D6 4-hydroxylates debrisoquine IEA Dictyostelium discoideum DDB_G0272604 R-DDI-211968 https://reactome.org/PathwayBrowser/#/R-DDI-211968 CYP2W1 oxidises INDOL IEA Dictyostelium discoideum DDB_G0272604 R-DDI-211983 https://reactome.org/PathwayBrowser/#/R-DDI-211983 CYP2J2 oxidises ARA IEA Dictyostelium discoideum DDB_G0272604 R-DDI-211988 https://reactome.org/PathwayBrowser/#/R-DDI-211988 CYP2C9 inactivates tolbutamide by 4methyl-hydroxylation IEA Dictyostelium discoideum DDB_G0272604 R-DDI-211991 https://reactome.org/PathwayBrowser/#/R-DDI-211991 Cyclophosphamide is 4-hydroxylated by CYP2B6 IEA Dictyostelium discoideum DDB_G0272604 R-DDI-212004 https://reactome.org/PathwayBrowser/#/R-DDI-212004 CYP2C18 initiates bioactivation of phenytoin by 4-hydroxylation IEA Dictyostelium discoideum DDB_G0272604 R-DDI-212005 https://reactome.org/PathwayBrowser/#/R-DDI-212005 CYP2F1 dehydrogenates 3-methylindole IEA Dictyostelium discoideum DDB_G0272604 R-DDI-2161814 https://reactome.org/PathwayBrowser/#/R-DDI-2161814 Arachidonate is hydroxylated to 19-HETE by CYP(2) IEA Dictyostelium discoideum DDB_G0272604 R-DDI-2161890 https://reactome.org/PathwayBrowser/#/R-DDI-2161890 Arachidonate is epoxidated to 5,6-EET by CYP(4) IEA Dictyostelium discoideum DDB_G0272604 R-DDI-2161899 https://reactome.org/PathwayBrowser/#/R-DDI-2161899 Arachidonate is epoxidated to 8,9-EET by CYP(5) IEA Dictyostelium discoideum DDB_G0272604 R-DDI-2161940 https://reactome.org/PathwayBrowser/#/R-DDI-2161940 Arachidonate is hydroxylated to 20-HETE by CYP(3) IEA Dictyostelium discoideum DDB_G0272604 R-DDI-5423647 https://reactome.org/PathwayBrowser/#/R-DDI-5423647 CYP2A13 oxidises AFM1 to AFM1E IEA Dictyostelium discoideum DDB_G0272604 R-DDI-76354 https://reactome.org/PathwayBrowser/#/R-DDI-76354 Vinyl chloride is oxidized to 2-Chloroethylene oxide IEA Dictyostelium discoideum DDB_G0272604 R-DDI-76397 https://reactome.org/PathwayBrowser/#/R-DDI-76397 Acetaminophen oxidised to N-acetylbenzoquinoneimine (NAPQI) IEA Dictyostelium discoideum DDB_G0272604 R-DDI-76416 https://reactome.org/PathwayBrowser/#/R-DDI-76416 Benzene is hydroxylated to phenol IEA Dictyostelium discoideum DDB_G0272604 R-DDI-76434 https://reactome.org/PathwayBrowser/#/R-DDI-76434 Dehalogenation of carbon tetrachloride to form a free radical IEA Dictyostelium discoideum DDB_G0272604 R-DDI-76453 https://reactome.org/PathwayBrowser/#/R-DDI-76453 Coumarin is 7-hydroxylated by CYP2A6 IEA Dictyostelium discoideum DDB_G0272604 R-DDI-76456 https://reactome.org/PathwayBrowser/#/R-DDI-76456 O-atom dealkylation of dextromethorphan IEA Dictyostelium discoideum DDB_G0272604 R-DDI-76475 https://reactome.org/PathwayBrowser/#/R-DDI-76475 Dehalogenation of the poly-halogenated hydrocarbon Halothane to form the acylhalide Trifluoroacetlychloride and hydrogen bromide IEA Dictyostelium discoideum DDB_G0272604 R-DDI-9027043 https://reactome.org/PathwayBrowser/#/R-DDI-9027043 CYPs hydroxylate DHA to 14(R)-HDHA IEA Dictyostelium discoideum DDB_G0272604 R-DDI-9027302 https://reactome.org/PathwayBrowser/#/R-DDI-9027302 CYP2E1 oxidises 14(S)-HDHA to 14(S),21(R)-diHDHA and 14(S),21(S)-diHDHA IEA Dictyostelium discoideum DDB_G0272604 R-DDI-9027321 https://reactome.org/PathwayBrowser/#/R-DDI-9027321 CYP2E1 oxidises 14(R)-HDHA to 14(R),21(R)-diHDHA and 14(R),21(S)-diHDHA IEA Dictyostelium discoideum DDB_G0272604 R-DDI-9680865 https://reactome.org/PathwayBrowser/#/R-DDI-9680865 CYP3A4, CYP2B6 bind ritonavir IEA Dictyostelium discoideum DDB_G0272604 R-DDI-9749986 https://reactome.org/PathwayBrowser/#/R-DDI-9749986 CYP2,3 cytochromes hydroxylate ST to 2,3-DHBA IEA Dictyostelium discoideum DDB_G0272604 R-DDI-9750016 https://reactome.org/PathwayBrowser/#/R-DDI-9750016 CYP2,3 cytochromes hydroxylate ST to 2,5-DHBA IEA Dictyostelium discoideum DDB_G0272604 R-DDI-9753285 https://reactome.org/PathwayBrowser/#/R-DDI-9753285 CYP2E1 monooxygenates APAP to NAPQI IEA Dictyostelium discoideum DDB_G0272604 R-DDI-9915971 https://reactome.org/PathwayBrowser/#/R-DDI-9915971 Arachidonate is epoxidated to 11,12-EET by CYP(5) IEA Dictyostelium discoideum DDB_G0272604 R-DDI-9915997 https://reactome.org/PathwayBrowser/#/R-DDI-9915997 Arachidonate is epoxidated to 14,15-EET by CYP(5) IEA Dictyostelium discoideum DDB_G0272616 R-DDI-111751 https://reactome.org/PathwayBrowser/#/R-DDI-111751 RNR (M1M2) reduces nucleotide diphosphates to deoxynucleotide diphosphates (thioredoxin) IEA Dictyostelium discoideum DDB_G0272616 R-DDI-111804 https://reactome.org/PathwayBrowser/#/R-DDI-111804 RNR (M1M2B) reduces nucleotide diphosphates to deoxynucleotide diphosphates (thioredoxin) IEA Dictyostelium discoideum DDB_G0272620 R-DDI-3371582 https://reactome.org/PathwayBrowser/#/R-DDI-3371582 HSBP1 binds HSF1 trimer IEA Dictyostelium discoideum DDB_G0272620 R-DDI-5082356 https://reactome.org/PathwayBrowser/#/R-DDI-5082356 HSF1-mediated gene expression IEA Dictyostelium discoideum DDB_G0272624 R-DDI-1236970 https://reactome.org/PathwayBrowser/#/R-DDI-1236970 Proteasomal clevage of exogenous antigen (26S proteasome catalyst) IEA Dictyostelium discoideum DDB_G0272624 R-DDI-1504193 https://reactome.org/PathwayBrowser/#/R-DDI-1504193 Ubiquitinated DVL is degraded by the proteasome IEA Dictyostelium discoideum DDB_G0272624 R-DDI-174058 https://reactome.org/PathwayBrowser/#/R-DDI-174058 Degradation of multiubiquitinated Cdh1 IEA Dictyostelium discoideum DDB_G0272624 R-DDI-174105 https://reactome.org/PathwayBrowser/#/R-DDI-174105 Degradation of multiubiquitinated cell cycle proteins IEA Dictyostelium discoideum DDB_G0272624 R-DDI-174202 https://reactome.org/PathwayBrowser/#/R-DDI-174202 Degradation of multiubiquitinated Securin IEA Dictyostelium discoideum DDB_G0272624 R-DDI-188191 https://reactome.org/PathwayBrowser/#/R-DDI-188191 APC/C:Cdh1-mediated degradation of Skp2 IEA Dictyostelium discoideum DDB_G0272624 R-DDI-264458 https://reactome.org/PathwayBrowser/#/R-DDI-264458 Proteasome mediated degradation of COP1 IEA Dictyostelium discoideum DDB_G0272624 R-DDI-450466 https://reactome.org/PathwayBrowser/#/R-DDI-450466 AUF1:mRNA complex is destroyed IEA Dictyostelium discoideum DDB_G0272624 R-DDI-5635854 https://reactome.org/PathwayBrowser/#/R-DDI-5635854 GLI2,3 are degraded by the proteasome IEA Dictyostelium discoideum DDB_G0272624 R-DDI-5658430 https://reactome.org/PathwayBrowser/#/R-DDI-5658430 NF1 is degraded by the proteasome IEA Dictyostelium discoideum DDB_G0272624 R-DDI-5665854 https://reactome.org/PathwayBrowser/#/R-DDI-5665854 ADRM1:26S proteaseome binds UCHL5 IEA Dictyostelium discoideum DDB_G0272624 R-DDI-5665871 https://reactome.org/PathwayBrowser/#/R-DDI-5665871 ADRM1 binds 26S proteasome IEA Dictyostelium discoideum DDB_G0272624 R-DDI-5687112 https://reactome.org/PathwayBrowser/#/R-DDI-5687112 MAPK6 is degraded by the 26S proteasome IEA Dictyostelium discoideum DDB_G0272624 R-DDI-5689539 https://reactome.org/PathwayBrowser/#/R-DDI-5689539 ADRM1:26S proteaseome binds USP14 IEA Dictyostelium discoideum DDB_G0272624 R-DDI-68948 https://reactome.org/PathwayBrowser/#/R-DDI-68948 Ubiquitinated Orc1 is degraded by the proteasome IEA Dictyostelium discoideum DDB_G0272624 R-DDI-69016 https://reactome.org/PathwayBrowser/#/R-DDI-69016 Ubiquitinated Cdc6 is degraded by the proteasome IEA Dictyostelium discoideum DDB_G0272624 R-DDI-69600 https://reactome.org/PathwayBrowser/#/R-DDI-69600 Proteolytic degradation of ubiquitinated-Cdc25A IEA Dictyostelium discoideum DDB_G0272624 R-DDI-8850992 https://reactome.org/PathwayBrowser/#/R-DDI-8850992 Proteasome degrades polyubiquitinated PTEN IEA Dictyostelium discoideum DDB_G0272624 R-DDI-8854044 https://reactome.org/PathwayBrowser/#/R-DDI-8854044 Proteasome degrades AURKA ubiquitinated by SCF-FBXL7 IEA Dictyostelium discoideum DDB_G0272624 R-DDI-8866553 https://reactome.org/PathwayBrowser/#/R-DDI-8866553 misfolded CFTR is degraded by the 26S proteasome IEA Dictyostelium discoideum DDB_G0272624 R-DDI-9755306 https://reactome.org/PathwayBrowser/#/R-DDI-9755306 ub UBXN7 is degraded by the 26S proteasome IEA Dictyostelium discoideum DDB_G0272624 R-DDI-983150 https://reactome.org/PathwayBrowser/#/R-DDI-983150 Proteasomal cleavage of substrate IEA Dictyostelium discoideum DDB_G0272624 R-DDI-9907980 https://reactome.org/PathwayBrowser/#/R-DDI-9907980 Formation of the 19S regulatory particle base precursor IEA Dictyostelium discoideum DDB_G0272624 R-DDI-9908026 https://reactome.org/PathwayBrowser/#/R-DDI-9908026 Formation of the 19S regulatory particle precursor IEA Dictyostelium discoideum DDB_G0272624 R-DDI-9908178 https://reactome.org/PathwayBrowser/#/R-DDI-9908178 Formation of the 26S proteasome IEA Dictyostelium discoideum DDB_G0272632 R-DDI-176054 https://reactome.org/PathwayBrowser/#/R-DDI-176054 GST dimers conjugate GSH with cytosolic substrates IEA Dictyostelium discoideum DDB_G0272632 R-DDI-2161701 https://reactome.org/PathwayBrowser/#/R-DDI-2161701 PGH2 is isomerised to PGD2 by HPGDS IEA Dictyostelium discoideum DDB_G0272632 R-DDI-3343700 https://reactome.org/PathwayBrowser/#/R-DDI-3343700 PRDX6:GSTP1 catalyzes 2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O IEA Dictyostelium discoideum DDB_G0272632 R-DDI-6798748 https://reactome.org/PathwayBrowser/#/R-DDI-6798748 Exocytosis of secretory granule lumen proteins IEA Dictyostelium discoideum DDB_G0272632 R-DDI-6800434 https://reactome.org/PathwayBrowser/#/R-DDI-6800434 Exocytosis of ficolin-rich granule lumen proteins IEA Dictyostelium discoideum DDB_G0272632 R-DDI-9663492 https://reactome.org/PathwayBrowser/#/R-DDI-9663492 BIL dissociates from GSTA1, FABP1 IEA Dictyostelium discoideum DDB_G0272632 R-DDI-9663511 https://reactome.org/PathwayBrowser/#/R-DDI-9663511 BIL binds GSTA1, FABP1 IEA Dictyostelium discoideum DDB_G0272632 R-DDI-9748996 https://reactome.org/PathwayBrowser/#/R-DDI-9748996 GST dimers cleave AZA to 6MP IEA Dictyostelium discoideum DDB_G0272632 R-DDI-9753280 https://reactome.org/PathwayBrowser/#/R-DDI-9753280 GSTs transfer GSH to NAPQI to form APAP-SG IEA Dictyostelium discoideum DDB_G0272634 R-DDI-204662 https://reactome.org/PathwayBrowser/#/R-DDI-204662 DOHH:Fe2+ hydroxylates Dhp-K50-EIF5A to form Hyp-K50-EIF5A IEA Dictyostelium discoideum DDB_G0272638 R-DDI-1675773 https://reactome.org/PathwayBrowser/#/R-DDI-1675773 PI(3,4)P2 is phosphorylated to PI(3,4,5)P3 by PIP5K1A-C at the plasma membrane IEA Dictyostelium discoideum DDB_G0272638 R-DDI-1675776 https://reactome.org/PathwayBrowser/#/R-DDI-1675776 PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers at the plasma membrane IEA Dictyostelium discoideum DDB_G0272638 R-DDI-1675810 https://reactome.org/PathwayBrowser/#/R-DDI-1675810 PI is phosphorylated to PI5P by PIP5K1A/B at the plasma membrane IEA Dictyostelium discoideum DDB_G0272638 R-DDI-1676082 https://reactome.org/PathwayBrowser/#/R-DDI-1676082 PI4P is phosphorylated to PI(4,5)P2 by PIP5K1A-C at the plasma membrane IEA Dictyostelium discoideum DDB_G0272638 R-DDI-1676134 https://reactome.org/PathwayBrowser/#/R-DDI-1676134 PI3P is phosphorylated to PI(3,5)P2 by PIP5K1A/B at the plasma membrane IEA Dictyostelium discoideum DDB_G0272638 R-DDI-1676145 https://reactome.org/PathwayBrowser/#/R-DDI-1676145 PI3P is phosphorylated to PI(3,4)P2 by PIP4K2/5K1 at the plasma membrane IEA Dictyostelium discoideum DDB_G0272638 R-DDI-6811522 https://reactome.org/PathwayBrowser/#/R-DDI-6811522 PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers in the nucleus IEA Dictyostelium discoideum DDB_G0272638 R-DDI-8868066 https://reactome.org/PathwayBrowser/#/R-DDI-8868066 PIP5K1C phosphorylates PI(4)P to PI(4,5)P2 IEA Dictyostelium discoideum DDB_G0272638 R-DDI-8877691 https://reactome.org/PathwayBrowser/#/R-DDI-8877691 MAP2K6 phosphorylates PIP4K2B IEA Dictyostelium discoideum DDB_G0272638 R-DDI-8877692 https://reactome.org/PathwayBrowser/#/R-DDI-8877692 PIN1 binds phosphorylated PIP4K2B IEA Dictyostelium discoideum DDB_G0272662 R-DDI-8870457 https://reactome.org/PathwayBrowser/#/R-DDI-8870457 FarC-PTP4A2 binds RABGGTB IEA Dictyostelium discoideum DDB_G0272662 R-DDI-8870461 https://reactome.org/PathwayBrowser/#/R-DDI-8870461 RABGGTA and RABGGTB bind IEA Dictyostelium discoideum DDB_G0272666 R-DDI-6807875 https://reactome.org/PathwayBrowser/#/R-DDI-6807875 ARFGAP, cargo, v-SNAREs and p24 proteins bind nascent COPI complex IEA Dictyostelium discoideum DDB_G0272666 R-DDI-6807877 https://reactome.org/PathwayBrowser/#/R-DDI-6807877 ARFGAPs stimulate ARF GTPase activity IEA Dictyostelium discoideum DDB_G0272666 R-DDI-6809003 https://reactome.org/PathwayBrowser/#/R-DDI-6809003 ERGIC-to-Golgi vesicles bind dynein:dynactin IEA Dictyostelium discoideum DDB_G0272666 R-DDI-6809011 https://reactome.org/PathwayBrowser/#/R-DDI-6809011 cis-Golgi t-SNAREs bind YKT6 on tethered vesicle IEA Dictyostelium discoideum DDB_G0272666 R-DDI-8952039 https://reactome.org/PathwayBrowser/#/R-DDI-8952039 NEDD8:AcM-UBE2F binds CRL5 E3 ubiquitin ligase complex IEA Dictyostelium discoideum DDB_G0272666 R-DDI-8952044 https://reactome.org/PathwayBrowser/#/R-DDI-8952044 AcM-UBE2F transfers NEDD8 to CRL5 E3 ubiquitin ligase complex IEA Dictyostelium discoideum DDB_G0272666 R-DDI-8955241 https://reactome.org/PathwayBrowser/#/R-DDI-8955241 CAND1 binds cytosolic CRL E3 ubiquitin ligases IEA Dictyostelium discoideum DDB_G0272666 R-DDI-8955289 https://reactome.org/PathwayBrowser/#/R-DDI-8955289 COMMDs displace CAND1 from cytosolic CRL E3 ubiquitin ligase complexes IEA Dictyostelium discoideum DDB_G0272666 R-DDI-8956040 https://reactome.org/PathwayBrowser/#/R-DDI-8956040 COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes IEA Dictyostelium discoideum DDB_G0272682 R-DDI-1606273 https://reactome.org/PathwayBrowser/#/R-DDI-1606273 SMPD2 and 3 hydrolyze sphingomyelin (plasma membrane) IEA Dictyostelium discoideum DDB_G0272684 R-DDI-71130 https://reactome.org/PathwayBrowser/#/R-DDI-71130 q-dihydrobiopterin + NADH + H+ => tetrahydrobiopterin + NAD+ IEA Dictyostelium discoideum DDB_G0272694 R-DDI-9013144 https://reactome.org/PathwayBrowser/#/R-DDI-9013144 RAC1 GAPs stimulate RAC1 GTPase activity IEA Dictyostelium discoideum DDB_G0272694 R-DDI-9013161 https://reactome.org/PathwayBrowser/#/R-DDI-9013161 CDC42 GAPs stimulate CDC42 GTPase activity IEA Dictyostelium discoideum DDB_G0272694 R-DDI-9018794 https://reactome.org/PathwayBrowser/#/R-DDI-9018794 RHOV binds effectors at the plasma membrane IEA Dictyostelium discoideum DDB_G0272694 R-DDI-9018806 https://reactome.org/PathwayBrowser/#/R-DDI-9018806 RAC3 GAPs stimulate RAC3 GTPase activity IEA Dictyostelium discoideum DDB_G0272696 R-DDI-9639287 https://reactome.org/PathwayBrowser/#/R-DDI-9639287 SESN1,2 binds L-leucine and dissociates from GATOR2 IEA Dictyostelium discoideum DDB_G0272696 R-DDI-9640195 https://reactome.org/PathwayBrowser/#/R-DDI-9640195 RRAGA,B hydrolyzes GTP IEA Dictyostelium discoideum DDB_G0272704 R-DDI-143468 https://reactome.org/PathwayBrowser/#/R-DDI-143468 MEOS oxidizes ethanol to acetaldehyde IEA Dictyostelium discoideum DDB_G0272704 R-DDI-156526 https://reactome.org/PathwayBrowser/#/R-DDI-156526 CYP1A2,3A4,3A5,2A13 oxidise AFB1 to AFXBO IEA Dictyostelium discoideum DDB_G0272704 R-DDI-211874 https://reactome.org/PathwayBrowser/#/R-DDI-211874 CYP2S1 4-hydroxylates atRA IEA Dictyostelium discoideum DDB_G0272704 R-DDI-211881 https://reactome.org/PathwayBrowser/#/R-DDI-211881 Coumarin is 7-hydroxylated by CYP2A13 IEA Dictyostelium discoideum DDB_G0272704 R-DDI-211910 https://reactome.org/PathwayBrowser/#/R-DDI-211910 CYP2C8 inactivates paclitaxel by 6alpha-hydroxylation IEA Dictyostelium discoideum DDB_G0272704 R-DDI-211929 https://reactome.org/PathwayBrowser/#/R-DDI-211929 CYP2C19 5-hydroxylates omeprazole IEA Dictyostelium discoideum DDB_G0272704 R-DDI-211960 https://reactome.org/PathwayBrowser/#/R-DDI-211960 CYP2U1 19-hydroxylates ARA IEA Dictyostelium discoideum DDB_G0272704 R-DDI-211966 https://reactome.org/PathwayBrowser/#/R-DDI-211966 CYP2D6 4-hydroxylates debrisoquine IEA Dictyostelium discoideum DDB_G0272704 R-DDI-211968 https://reactome.org/PathwayBrowser/#/R-DDI-211968 CYP2W1 oxidises INDOL IEA Dictyostelium discoideum DDB_G0272704 R-DDI-211983 https://reactome.org/PathwayBrowser/#/R-DDI-211983 CYP2J2 oxidises ARA IEA Dictyostelium discoideum DDB_G0272704 R-DDI-211988 https://reactome.org/PathwayBrowser/#/R-DDI-211988 CYP2C9 inactivates tolbutamide by 4methyl-hydroxylation IEA Dictyostelium discoideum DDB_G0272704 R-DDI-211991 https://reactome.org/PathwayBrowser/#/R-DDI-211991 Cyclophosphamide is 4-hydroxylated by CYP2B6 IEA Dictyostelium discoideum DDB_G0272704 R-DDI-212004 https://reactome.org/PathwayBrowser/#/R-DDI-212004 CYP2C18 initiates bioactivation of phenytoin by 4-hydroxylation IEA Dictyostelium discoideum DDB_G0272704 R-DDI-212005 https://reactome.org/PathwayBrowser/#/R-DDI-212005 CYP2F1 dehydrogenates 3-methylindole IEA Dictyostelium discoideum DDB_G0272704 R-DDI-2161814 https://reactome.org/PathwayBrowser/#/R-DDI-2161814 Arachidonate is hydroxylated to 19-HETE by CYP(2) IEA Dictyostelium discoideum DDB_G0272704 R-DDI-2161890 https://reactome.org/PathwayBrowser/#/R-DDI-2161890 Arachidonate is epoxidated to 5,6-EET by CYP(4) IEA Dictyostelium discoideum DDB_G0272704 R-DDI-2161899 https://reactome.org/PathwayBrowser/#/R-DDI-2161899 Arachidonate is epoxidated to 8,9-EET by CYP(5) IEA Dictyostelium discoideum DDB_G0272704 R-DDI-2161940 https://reactome.org/PathwayBrowser/#/R-DDI-2161940 Arachidonate is hydroxylated to 20-HETE by CYP(3) IEA Dictyostelium discoideum DDB_G0272704 R-DDI-5423647 https://reactome.org/PathwayBrowser/#/R-DDI-5423647 CYP2A13 oxidises AFM1 to AFM1E IEA Dictyostelium discoideum DDB_G0272704 R-DDI-76354 https://reactome.org/PathwayBrowser/#/R-DDI-76354 Vinyl chloride is oxidized to 2-Chloroethylene oxide IEA Dictyostelium discoideum DDB_G0272704 R-DDI-76397 https://reactome.org/PathwayBrowser/#/R-DDI-76397 Acetaminophen oxidised to N-acetylbenzoquinoneimine (NAPQI) IEA Dictyostelium discoideum DDB_G0272704 R-DDI-76416 https://reactome.org/PathwayBrowser/#/R-DDI-76416 Benzene is hydroxylated to phenol IEA Dictyostelium discoideum DDB_G0272704 R-DDI-76434 https://reactome.org/PathwayBrowser/#/R-DDI-76434 Dehalogenation of carbon tetrachloride to form a free radical IEA Dictyostelium discoideum DDB_G0272704 R-DDI-76453 https://reactome.org/PathwayBrowser/#/R-DDI-76453 Coumarin is 7-hydroxylated by CYP2A6 IEA Dictyostelium discoideum DDB_G0272704 R-DDI-76456 https://reactome.org/PathwayBrowser/#/R-DDI-76456 O-atom dealkylation of dextromethorphan IEA Dictyostelium discoideum DDB_G0272704 R-DDI-76475 https://reactome.org/PathwayBrowser/#/R-DDI-76475 Dehalogenation of the poly-halogenated hydrocarbon Halothane to form the acylhalide Trifluoroacetlychloride and hydrogen bromide IEA Dictyostelium discoideum DDB_G0272704 R-DDI-9027043 https://reactome.org/PathwayBrowser/#/R-DDI-9027043 CYPs hydroxylate DHA to 14(R)-HDHA IEA Dictyostelium discoideum DDB_G0272704 R-DDI-9027302 https://reactome.org/PathwayBrowser/#/R-DDI-9027302 CYP2E1 oxidises 14(S)-HDHA to 14(S),21(R)-diHDHA and 14(S),21(S)-diHDHA IEA Dictyostelium discoideum DDB_G0272704 R-DDI-9027321 https://reactome.org/PathwayBrowser/#/R-DDI-9027321 CYP2E1 oxidises 14(R)-HDHA to 14(R),21(R)-diHDHA and 14(R),21(S)-diHDHA IEA Dictyostelium discoideum DDB_G0272704 R-DDI-9680865 https://reactome.org/PathwayBrowser/#/R-DDI-9680865 CYP3A4, CYP2B6 bind ritonavir IEA Dictyostelium discoideum DDB_G0272704 R-DDI-9749986 https://reactome.org/PathwayBrowser/#/R-DDI-9749986 CYP2,3 cytochromes hydroxylate ST to 2,3-DHBA IEA Dictyostelium discoideum DDB_G0272704 R-DDI-9750016 https://reactome.org/PathwayBrowser/#/R-DDI-9750016 CYP2,3 cytochromes hydroxylate ST to 2,5-DHBA IEA Dictyostelium discoideum DDB_G0272704 R-DDI-9753285 https://reactome.org/PathwayBrowser/#/R-DDI-9753285 CYP2E1 monooxygenates APAP to NAPQI IEA Dictyostelium discoideum DDB_G0272704 R-DDI-9915971 https://reactome.org/PathwayBrowser/#/R-DDI-9915971 Arachidonate is epoxidated to 11,12-EET by CYP(5) IEA Dictyostelium discoideum DDB_G0272704 R-DDI-9915997 https://reactome.org/PathwayBrowser/#/R-DDI-9915997 Arachidonate is epoxidated to 14,15-EET by CYP(5) IEA Dictyostelium discoideum DDB_G0272708 R-DDI-8931974 https://reactome.org/PathwayBrowser/#/R-DDI-8931974 N6AMT2 transfers 3xCH3 from 3xAdoMet to EEF1A IEA Dictyostelium discoideum DDB_G0272730 R-DDI-446208 https://reactome.org/PathwayBrowser/#/R-DDI-446208 Addition of a second mannose to the N-glycan precursor by ALG2 IEA Dictyostelium discoideum DDB_G0272732 R-DDI-6791222 https://reactome.org/PathwayBrowser/#/R-DDI-6791222 21S pre-rRNA is nucleolytically processed at site E (site2a) to yield 18SE pre-rRNA IEA Dictyostelium discoideum DDB_G0272732 R-DDI-6791227 https://reactome.org/PathwayBrowser/#/R-DDI-6791227 47S pre-rRNA is nucleolytically processed at A' (01,A1), site A0, and site 02 (site 6) to yield 45S pre-rRNA IEA Dictyostelium discoideum DDB_G0272740 R-DDI-110364 https://reactome.org/PathwayBrowser/#/R-DDI-110364 PCNA:POLD,POLE:RPA:RFC and FEN1 bind APEX1 IEA Dictyostelium discoideum DDB_G0272740 R-DDI-110368 https://reactome.org/PathwayBrowser/#/R-DDI-110368 POLD,POLE-mediated DNA strand displacement synthesis IEA Dictyostelium discoideum DDB_G0272740 R-DDI-110371 https://reactome.org/PathwayBrowser/#/R-DDI-110371 LIG1 binds APEX1 and PCNA at SSB IEA Dictyostelium discoideum DDB_G0272740 R-DDI-5651805 https://reactome.org/PathwayBrowser/#/R-DDI-5651805 LIG1 bound to APEX1 and PCNA ligates SSB IEA Dictyostelium discoideum DDB_G0272740 R-DDI-5652005 https://reactome.org/PathwayBrowser/#/R-DDI-5652005 RAD18:UBE2B or RBX1:CUL4:DDB1:DTL ubiquitin ligase complex binds PCNA:POLD,POLE:RPA:RFC associated with damaged dsDNA IEA Dictyostelium discoideum DDB_G0272740 R-DDI-5652009 https://reactome.org/PathwayBrowser/#/R-DDI-5652009 RAD18:UBE2B or RBX1:CUL4:DDB1:DTL monoubiquitinates PCNA IEA Dictyostelium discoideum DDB_G0272740 R-DDI-5653838 https://reactome.org/PathwayBrowser/#/R-DDI-5653838 POLD,POLE binds deISGylated PCNA after TLS IEA Dictyostelium discoideum DDB_G0272740 R-DDI-5691001 https://reactome.org/PathwayBrowser/#/R-DDI-5691001 Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in GG-NER IEA Dictyostelium discoideum DDB_G0272740 R-DDI-6782208 https://reactome.org/PathwayBrowser/#/R-DDI-6782208 Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in TC-NER IEA Dictyostelium discoideum DDB_G0272740 R-DDI-6782211 https://reactome.org/PathwayBrowser/#/R-DDI-6782211 DNA polymerases delta, epsilon or kappa bind the TC-NER site IEA Dictyostelium discoideum DDB_G0272740 R-DDI-6782227 https://reactome.org/PathwayBrowser/#/R-DDI-6782227 Ligation of newly synthesized repair patch to incised DNA in TC-NER IEA Dictyostelium discoideum DDB_G0272740 R-DDI-68913 https://reactome.org/PathwayBrowser/#/R-DDI-68913 The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer at the origin IEA Dictyostelium discoideum DDB_G0272740 R-DDI-68914 https://reactome.org/PathwayBrowser/#/R-DDI-68914 DNA polymerase alpha:primase binds at the origin IEA Dictyostelium discoideum DDB_G0272740 R-DDI-68960 https://reactome.org/PathwayBrowser/#/R-DDI-68960 DNA polymerase epsilon binds at the origin IEA Dictyostelium discoideum DDB_G0272742 R-DDI-1566981 https://reactome.org/PathwayBrowser/#/R-DDI-1566981 Fibronectin degradation by MMP1, 3, 7, 12, 13, 19, CTSS IEA Dictyostelium discoideum DDB_G0272742 R-DDI-2130706 https://reactome.org/PathwayBrowser/#/R-DDI-2130706 MHC class II antigen processing IEA Dictyostelium discoideum DDB_G0272742 R-DDI-6798745 https://reactome.org/PathwayBrowser/#/R-DDI-6798745 Exocytosis of tertiary granule lumen proteins IEA Dictyostelium discoideum DDB_G0272742 R-DDI-6800434 https://reactome.org/PathwayBrowser/#/R-DDI-6800434 Exocytosis of ficolin-rich granule lumen proteins IEA Dictyostelium discoideum DDB_G0272754 R-DDI-3323079 https://reactome.org/PathwayBrowser/#/R-DDI-3323079 GSR catalyzes glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+ IEA Dictyostelium discoideum DDB_G0272754 R-DDI-71682 https://reactome.org/PathwayBrowser/#/R-DDI-71682 glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+ IEA Dictyostelium discoideum DDB_G0272760 R-DDI-68914 https://reactome.org/PathwayBrowser/#/R-DDI-68914 DNA polymerase alpha:primase binds at the origin IEA Dictyostelium discoideum DDB_G0272760 R-DDI-68917 https://reactome.org/PathwayBrowser/#/R-DDI-68917 Cdc45 associates with the pre-replicative complex at the origin IEA Dictyostelium discoideum DDB_G0272760 R-DDI-68960 https://reactome.org/PathwayBrowser/#/R-DDI-68960 DNA polymerase epsilon binds at the origin IEA Dictyostelium discoideum DDB_G0272760 R-DDI-69019 https://reactome.org/PathwayBrowser/#/R-DDI-69019 Mcm4,6,7 trimer forms and associates with the replication fork IEA Dictyostelium discoideum DDB_G0272760 R-DDI-9749253 https://reactome.org/PathwayBrowser/#/R-DDI-9749253 Formation of MCM2-7 complex IEA Dictyostelium discoideum DDB_G0272760 R-DDI-9757257 https://reactome.org/PathwayBrowser/#/R-DDI-9757257 MCM4, MCM6 and MCM7 form a heterotrimer IEA Dictyostelium discoideum DDB_G0272760 R-DDI-9757258 https://reactome.org/PathwayBrowser/#/R-DDI-9757258 MCM2 binds MCM4:MCM6:MCM7 heterotrimer IEA Dictyostelium discoideum DDB_G0272765 R-DDI-1614460 https://reactome.org/PathwayBrowser/#/R-DDI-1614460 Dimerization of procollagen type VI IEA Dictyostelium discoideum DDB_G0272765 R-DDI-1614461 https://reactome.org/PathwayBrowser/#/R-DDI-1614461 Tetramerization of procollagen VI IEA Dictyostelium discoideum DDB_G0272765 R-DDI-2213207 https://reactome.org/PathwayBrowser/#/R-DDI-2213207 Formation of collagen networks IEA Dictyostelium discoideum DDB_G0272765 R-DDI-8944215 https://reactome.org/PathwayBrowser/#/R-DDI-8944215 Association of procollagen type XX IEA Dictyostelium discoideum DDB_G0272765 R-DDI-8944227 https://reactome.org/PathwayBrowser/#/R-DDI-8944227 Association of procollagen type XXII IEA Dictyostelium discoideum DDB_G0272765 R-DDI-8944232 https://reactome.org/PathwayBrowser/#/R-DDI-8944232 Association of procollagen type XII IEA Dictyostelium discoideum DDB_G0272765 R-DDI-8944236 https://reactome.org/PathwayBrowser/#/R-DDI-8944236 Association of procollagen type XIV IEA Dictyostelium discoideum DDB_G0272765 R-DDI-8944246 https://reactome.org/PathwayBrowser/#/R-DDI-8944246 Association of procollagen type XXI IEA Dictyostelium discoideum DDB_G0272765 R-DDI-8944247 https://reactome.org/PathwayBrowser/#/R-DDI-8944247 Association of procollagen type VI IEA Dictyostelium discoideum DDB_G0272775 R-DDI-141423 https://reactome.org/PathwayBrowser/#/R-DDI-141423 Binding of the MCC complex to the APC/C complex IEA Dictyostelium discoideum DDB_G0272775 R-DDI-174057 https://reactome.org/PathwayBrowser/#/R-DDI-174057 Multiubiquitination of APC/C-associated Cdh1 IEA Dictyostelium discoideum DDB_G0272775 R-DDI-174058 https://reactome.org/PathwayBrowser/#/R-DDI-174058 Degradation of multiubiquitinated Cdh1 IEA Dictyostelium discoideum DDB_G0272775 R-DDI-174070 https://reactome.org/PathwayBrowser/#/R-DDI-174070 Association of Cdh1 with the APC/C IEA Dictyostelium discoideum DDB_G0272775 R-DDI-174079 https://reactome.org/PathwayBrowser/#/R-DDI-174079 Phosphorylation of Cdh1 by Cyclin A:Cdk2 IEA Dictyostelium discoideum DDB_G0272775 R-DDI-174088 https://reactome.org/PathwayBrowser/#/R-DDI-174088 Association of cell cycle proteins with the APC/C:Cdh1 complex IEA Dictyostelium discoideum DDB_G0272775 R-DDI-174104 https://reactome.org/PathwayBrowser/#/R-DDI-174104 Ubiquitination of Cyclin A by APC/C:Cdc20 complex IEA Dictyostelium discoideum DDB_G0272775 R-DDI-174105 https://reactome.org/PathwayBrowser/#/R-DDI-174105 Degradation of multiubiquitinated cell cycle proteins IEA Dictyostelium discoideum DDB_G0272775 R-DDI-174119 https://reactome.org/PathwayBrowser/#/R-DDI-174119 Free APC/C phosphorylated by Plk1 IEA Dictyostelium discoideum DDB_G0272775 R-DDI-174139 https://reactome.org/PathwayBrowser/#/R-DDI-174139 Dissociation of phospho-Cdh1 from the APC/C complex IEA Dictyostelium discoideum DDB_G0272775 R-DDI-174144 https://reactome.org/PathwayBrowser/#/R-DDI-174144 Ubiquitination of Securin by phospho-APC/C:Cdc20 complex IEA Dictyostelium discoideum DDB_G0272775 R-DDI-174195 https://reactome.org/PathwayBrowser/#/R-DDI-174195 Ubiquitination of cell cycle proteins targeted by the APC/C:Cdh1complex IEA Dictyostelium discoideum DDB_G0272775 R-DDI-174202 https://reactome.org/PathwayBrowser/#/R-DDI-174202 Degradation of multiubiquitinated Securin IEA Dictyostelium discoideum DDB_G0272775 R-DDI-174224 https://reactome.org/PathwayBrowser/#/R-DDI-174224 Dissociation of Cdc20 from APC/C complex IEA Dictyostelium discoideum DDB_G0272775 R-DDI-174227 https://reactome.org/PathwayBrowser/#/R-DDI-174227 Ubiquitination of Cyclin B by phospho-APC/C:Cdc20 complex IEA Dictyostelium discoideum DDB_G0272775 R-DDI-174238 https://reactome.org/PathwayBrowser/#/R-DDI-174238 Activation of APC/C:Cdc20 by dissociation of Cdc20:phospho-APC/C from Cdc20:phospho-APC/C:Mad2:Bub3:BubR1 IEA Dictyostelium discoideum DDB_G0272775 R-DDI-179410 https://reactome.org/PathwayBrowser/#/R-DDI-179410 Association of Nek2A with MCC:APC/C IEA Dictyostelium discoideum DDB_G0272775 R-DDI-179417 https://reactome.org/PathwayBrowser/#/R-DDI-179417 Multiubiquitination of Nek2A IEA Dictyostelium discoideum DDB_G0272775 R-DDI-179421 https://reactome.org/PathwayBrowser/#/R-DDI-179421 Degradation of multiubiquitinated Nek2A IEA Dictyostelium discoideum DDB_G0272775 R-DDI-188191 https://reactome.org/PathwayBrowser/#/R-DDI-188191 APC/C:Cdh1-mediated degradation of Skp2 IEA Dictyostelium discoideum DDB_G0272775 R-DDI-3788705 https://reactome.org/PathwayBrowser/#/R-DDI-3788705 CDKN1A (p21) prevents phosphorylation of Cdh1 by Cyclin A:Cdk2 IEA Dictyostelium discoideum DDB_G0272775 R-DDI-3788724 https://reactome.org/PathwayBrowser/#/R-DDI-3788724 Cdh1:APC/C ubiquitinates EHMT1 and EHMT2 IEA Dictyostelium discoideum DDB_G0272775 R-DDI-69015 https://reactome.org/PathwayBrowser/#/R-DDI-69015 Cytoplasmic phosphorylated Cdc6 is ubiquitinated by the anaphase-promoting complex IEA Dictyostelium discoideum DDB_G0272775 R-DDI-9686969 https://reactome.org/PathwayBrowser/#/R-DDI-9686969 APC/C:Cdh1 polyubiquitinates SKP2 IEA Dictyostelium discoideum DDB_G0272775 R-DDI-983140 https://reactome.org/PathwayBrowser/#/R-DDI-983140 Transfer of Ub from E2 to substrate and release of E2 IEA Dictyostelium discoideum DDB_G0272775 R-DDI-983147 https://reactome.org/PathwayBrowser/#/R-DDI-983147 Release of E3 from polyubiquitinated substrate IEA Dictyostelium discoideum DDB_G0272775 R-DDI-983156 https://reactome.org/PathwayBrowser/#/R-DDI-983156 Polyubiquitination of substrate IEA Dictyostelium discoideum DDB_G0272775 R-DDI-983157 https://reactome.org/PathwayBrowser/#/R-DDI-983157 Interaction of E3 with substrate and E2-Ub complex IEA Dictyostelium discoideum DDB_G0272781 R-DDI-446201 https://reactome.org/PathwayBrowser/#/R-DDI-446201 PMM1,2 isomerise Man6P to Man1P IEA Dictyostelium discoideum DDB_G0272787 R-DDI-9014627 https://reactome.org/PathwayBrowser/#/R-DDI-9014627 SDS dimers:PXLP dehydrate L-Thr to 2AA IEA Dictyostelium discoideum DDB_G0272799 R-DDI-6788650 https://reactome.org/PathwayBrowser/#/R-DDI-6788650 ICMT:Zn2+ transfers CH3 from AdoMet to isoprenylated proteins IEA Dictyostelium discoideum DDB_G0272813 R-DDI-1363303 https://reactome.org/PathwayBrowser/#/R-DDI-1363303 p130 (RBL2) in complex with E2F4/5:DP1/2 binds to cyclin E/A:CDK2 IEA Dictyostelium discoideum DDB_G0272813 R-DDI-1363306 https://reactome.org/PathwayBrowser/#/R-DDI-1363306 p130 (RBL2) binds Cyclin E/A:CDK2 IEA Dictyostelium discoideum DDB_G0272813 R-DDI-1363311 https://reactome.org/PathwayBrowser/#/R-DDI-1363311 p107 (RBL1) in complex with E2F4:DP1/2 binds to cyclin E/A:CDK2 IEA Dictyostelium discoideum DDB_G0272813 R-DDI-1363314 https://reactome.org/PathwayBrowser/#/R-DDI-1363314 p107 (RBL1) binds CyclinE/A:CDK2 IEA Dictyostelium discoideum DDB_G0272813 R-DDI-174079 https://reactome.org/PathwayBrowser/#/R-DDI-174079 Phosphorylation of Cdh1 by Cyclin A:Cdk2 IEA Dictyostelium discoideum DDB_G0272813 R-DDI-3215385 https://reactome.org/PathwayBrowser/#/R-DDI-3215385 CDK4 in CCND1:CDK4:PRMT5:WDR77 phosphorylates WDR77 IEA Dictyostelium discoideum DDB_G0272813 R-DDI-3788705 https://reactome.org/PathwayBrowser/#/R-DDI-3788705 CDKN1A (p21) prevents phosphorylation of Cdh1 by Cyclin A:Cdk2 IEA Dictyostelium discoideum DDB_G0272813 R-DDI-5205799 https://reactome.org/PathwayBrowser/#/R-DDI-5205799 CCND1:CDK4:PRMT5:pT5-WDR77 methylates arginine-9 of histone H3 (H3R8) IEA Dictyostelium discoideum DDB_G0272813 R-DDI-5661117 https://reactome.org/PathwayBrowser/#/R-DDI-5661117 CCND1:CDK4:PRMT5:pT5-WDR77 methylates methyl-arginine-9 of histone H3 IEA Dictyostelium discoideum DDB_G0272813 R-DDI-68914 https://reactome.org/PathwayBrowser/#/R-DDI-68914 DNA polymerase alpha:primase binds at the origin IEA Dictyostelium discoideum DDB_G0272813 R-DDI-68917 https://reactome.org/PathwayBrowser/#/R-DDI-68917 Cdc45 associates with the pre-replicative complex at the origin IEA Dictyostelium discoideum DDB_G0272813 R-DDI-68960 https://reactome.org/PathwayBrowser/#/R-DDI-68960 DNA polymerase epsilon binds at the origin IEA Dictyostelium discoideum DDB_G0272815 R-DDI-1566981 https://reactome.org/PathwayBrowser/#/R-DDI-1566981 Fibronectin degradation by MMP1, 3, 7, 12, 13, 19, CTSS IEA Dictyostelium discoideum DDB_G0272815 R-DDI-2130706 https://reactome.org/PathwayBrowser/#/R-DDI-2130706 MHC class II antigen processing IEA Dictyostelium discoideum DDB_G0272815 R-DDI-6798745 https://reactome.org/PathwayBrowser/#/R-DDI-6798745 Exocytosis of tertiary granule lumen proteins IEA Dictyostelium discoideum DDB_G0272815 R-DDI-6800434 https://reactome.org/PathwayBrowser/#/R-DDI-6800434 Exocytosis of ficolin-rich granule lumen proteins IEA Dictyostelium discoideum DDB_G0272825 R-DDI-156823 https://reactome.org/PathwayBrowser/#/R-DDI-156823 Association of phospho-L13a with GAIT element of Ceruloplasmin mRNA IEA Dictyostelium discoideum DDB_G0272825 R-DDI-1799332 https://reactome.org/PathwayBrowser/#/R-DDI-1799332 Nascent polypeptide:mRNA:ribosome complex binds signal recognition particle (SRP) IEA Dictyostelium discoideum DDB_G0272825 R-DDI-72621 https://reactome.org/PathwayBrowser/#/R-DDI-72621 Ribosomal scanning IEA Dictyostelium discoideum DDB_G0272825 R-DDI-72671 https://reactome.org/PathwayBrowser/#/R-DDI-72671 eIF5B:GTP is hydrolyzed and released IEA Dictyostelium discoideum DDB_G0272825 R-DDI-72672 https://reactome.org/PathwayBrowser/#/R-DDI-72672 The 60S subunit joins the translation initiation complex IEA Dictyostelium discoideum DDB_G0272825 R-DDI-72673 https://reactome.org/PathwayBrowser/#/R-DDI-72673 Release of 40S and 60S subunits from the 80S ribosome IEA Dictyostelium discoideum DDB_G0272825 R-DDI-72676 https://reactome.org/PathwayBrowser/#/R-DDI-72676 eIF3 and eIF1A bind to the 40S subunit IEA Dictyostelium discoideum DDB_G0272825 R-DDI-72691 https://reactome.org/PathwayBrowser/#/R-DDI-72691 Formation of the 43S pre-initiation complex IEA Dictyostelium discoideum DDB_G0272825 R-DDI-72697 https://reactome.org/PathwayBrowser/#/R-DDI-72697 Start codon recognition IEA Dictyostelium discoideum DDB_G0272825 R-DDI-927789 https://reactome.org/PathwayBrowser/#/R-DDI-927789 Formation of UPF1:eRF3 complex on mRNA with a premature termination codon and no Exon Junction Complex IEA Dictyostelium discoideum DDB_G0272825 R-DDI-927832 https://reactome.org/PathwayBrowser/#/R-DDI-927832 UPF1 binds an mRNP with a termination codon preceding an Exon Junction Complex IEA Dictyostelium discoideum DDB_G0272825 R-DDI-927889 https://reactome.org/PathwayBrowser/#/R-DDI-927889 SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex) IEA Dictyostelium discoideum DDB_G0272831 R-DDI-1236970 https://reactome.org/PathwayBrowser/#/R-DDI-1236970 Proteasomal clevage of exogenous antigen (26S proteasome catalyst) IEA Dictyostelium discoideum DDB_G0272831 R-DDI-1504193 https://reactome.org/PathwayBrowser/#/R-DDI-1504193 Ubiquitinated DVL is degraded by the proteasome IEA Dictyostelium discoideum DDB_G0272831 R-DDI-174058 https://reactome.org/PathwayBrowser/#/R-DDI-174058 Degradation of multiubiquitinated Cdh1 IEA Dictyostelium discoideum DDB_G0272831 R-DDI-174105 https://reactome.org/PathwayBrowser/#/R-DDI-174105 Degradation of multiubiquitinated cell cycle proteins IEA Dictyostelium discoideum DDB_G0272831 R-DDI-174202 https://reactome.org/PathwayBrowser/#/R-DDI-174202 Degradation of multiubiquitinated Securin IEA Dictyostelium discoideum DDB_G0272831 R-DDI-188191 https://reactome.org/PathwayBrowser/#/R-DDI-188191 APC/C:Cdh1-mediated degradation of Skp2 IEA Dictyostelium discoideum DDB_G0272831 R-DDI-264458 https://reactome.org/PathwayBrowser/#/R-DDI-264458 Proteasome mediated degradation of COP1 IEA Dictyostelium discoideum DDB_G0272831 R-DDI-450466 https://reactome.org/PathwayBrowser/#/R-DDI-450466 AUF1:mRNA complex is destroyed IEA Dictyostelium discoideum DDB_G0272831 R-DDI-5635854 https://reactome.org/PathwayBrowser/#/R-DDI-5635854 GLI2,3 are degraded by the proteasome IEA Dictyostelium discoideum DDB_G0272831 R-DDI-5658430 https://reactome.org/PathwayBrowser/#/R-DDI-5658430 NF1 is degraded by the proteasome IEA Dictyostelium discoideum DDB_G0272831 R-DDI-5665854 https://reactome.org/PathwayBrowser/#/R-DDI-5665854 ADRM1:26S proteaseome binds UCHL5 IEA Dictyostelium discoideum DDB_G0272831 R-DDI-5665871 https://reactome.org/PathwayBrowser/#/R-DDI-5665871 ADRM1 binds 26S proteasome IEA Dictyostelium discoideum DDB_G0272831 R-DDI-5687112 https://reactome.org/PathwayBrowser/#/R-DDI-5687112 MAPK6 is degraded by the 26S proteasome IEA Dictyostelium discoideum DDB_G0272831 R-DDI-5689539 https://reactome.org/PathwayBrowser/#/R-DDI-5689539 ADRM1:26S proteaseome binds USP14 IEA Dictyostelium discoideum DDB_G0272831 R-DDI-68948 https://reactome.org/PathwayBrowser/#/R-DDI-68948 Ubiquitinated Orc1 is degraded by the proteasome IEA Dictyostelium discoideum DDB_G0272831 R-DDI-69016 https://reactome.org/PathwayBrowser/#/R-DDI-69016 Ubiquitinated Cdc6 is degraded by the proteasome IEA Dictyostelium discoideum DDB_G0272831 R-DDI-69600 https://reactome.org/PathwayBrowser/#/R-DDI-69600 Proteolytic degradation of ubiquitinated-Cdc25A IEA Dictyostelium discoideum DDB_G0272831 R-DDI-8850992 https://reactome.org/PathwayBrowser/#/R-DDI-8850992 Proteasome degrades polyubiquitinated PTEN IEA Dictyostelium discoideum DDB_G0272831 R-DDI-8854044 https://reactome.org/PathwayBrowser/#/R-DDI-8854044 Proteasome degrades AURKA ubiquitinated by SCF-FBXL7 IEA Dictyostelium discoideum DDB_G0272831 R-DDI-8866553 https://reactome.org/PathwayBrowser/#/R-DDI-8866553 misfolded CFTR is degraded by the 26S proteasome IEA Dictyostelium discoideum DDB_G0272831 R-DDI-9755306 https://reactome.org/PathwayBrowser/#/R-DDI-9755306 ub UBXN7 is degraded by the 26S proteasome IEA Dictyostelium discoideum DDB_G0272831 R-DDI-983150 https://reactome.org/PathwayBrowser/#/R-DDI-983150 Proteasomal cleavage of substrate IEA Dictyostelium discoideum DDB_G0272831 R-DDI-9907912 https://reactome.org/PathwayBrowser/#/R-DDI-9907912 Formation of the outer ring of the 20S core particle IEA Dictyostelium discoideum DDB_G0272831 R-DDI-9907919 https://reactome.org/PathwayBrowser/#/R-DDI-9907919 Formation of the preholoproteasome IEA Dictyostelium discoideum DDB_G0272831 R-DDI-9907925 https://reactome.org/PathwayBrowser/#/R-DDI-9907925 Formation of the inner ring of the 20S immunoproteasome core particle IEA Dictyostelium discoideum DDB_G0272831 R-DDI-9907928 https://reactome.org/PathwayBrowser/#/R-DDI-9907928 Formation of the inner ring of the 20S thymoproteasome core particle IEA Dictyostelium discoideum DDB_G0272831 R-DDI-9907940 https://reactome.org/PathwayBrowser/#/R-DDI-9907940 Formation of the preholothymoproteasome IEA Dictyostelium discoideum DDB_G0272831 R-DDI-9907941 https://reactome.org/PathwayBrowser/#/R-DDI-9907941 Fromation of the preholoimmunoproteasome IEA Dictyostelium discoideum DDB_G0272831 R-DDI-9908052 https://reactome.org/PathwayBrowser/#/R-DDI-9908052 PSMG1:PSMG2 dimer binds the 20S core particle outer ring IEA Dictyostelium discoideum DDB_G0272831 R-DDI-9908069 https://reactome.org/PathwayBrowser/#/R-DDI-9908069 POMP binds the 20S core particle outer ring IEA Dictyostelium discoideum DDB_G0272831 R-DDI-9908178 https://reactome.org/PathwayBrowser/#/R-DDI-9908178 Formation of the 26S proteasome IEA Dictyostelium discoideum DDB_G0272831 R-DDI-9908709 https://reactome.org/PathwayBrowser/#/R-DDI-9908709 Formation of the PA28-alpha-beta-20S proteasome IEA Dictyostelium discoideum DDB_G0272831 R-DDI-9908721 https://reactome.org/PathwayBrowser/#/R-DDI-9908721 Formation of the PA28gamma-20S proteasome IEA Dictyostelium discoideum DDB_G0272857 R-DDI-6798747 https://reactome.org/PathwayBrowser/#/R-DDI-6798747 Exocytosis of tertiary granule membrane proteins IEA Dictyostelium discoideum DDB_G0272857 R-DDI-6799350 https://reactome.org/PathwayBrowser/#/R-DDI-6799350 Exocytosis of specific granule membrane proteins IEA Dictyostelium discoideum DDB_G0272871 R-DDI-6814555 https://reactome.org/PathwayBrowser/#/R-DDI-6814555 Integrator complex processes the 3' end of snRNA IEA Dictyostelium discoideum DDB_G0272875 R-DDI-5333678 https://reactome.org/PathwayBrowser/#/R-DDI-5333678 CPNEs bind PL IEA Dictyostelium discoideum DDB_G0272875 R-DDI-6798739 https://reactome.org/PathwayBrowser/#/R-DDI-6798739 Exocytosis of azurophil granule membrane proteins IEA Dictyostelium discoideum DDB_G0272893 R-DDI-156826 https://reactome.org/PathwayBrowser/#/R-DDI-156826 Dissociation of L13a from the 60s ribosomal subunit IEA Dictyostelium discoideum DDB_G0272893 R-DDI-1799332 https://reactome.org/PathwayBrowser/#/R-DDI-1799332 Nascent polypeptide:mRNA:ribosome complex binds signal recognition particle (SRP) IEA Dictyostelium discoideum DDB_G0272893 R-DDI-72671 https://reactome.org/PathwayBrowser/#/R-DDI-72671 eIF5B:GTP is hydrolyzed and released IEA Dictyostelium discoideum DDB_G0272893 R-DDI-72672 https://reactome.org/PathwayBrowser/#/R-DDI-72672 The 60S subunit joins the translation initiation complex IEA Dictyostelium discoideum DDB_G0272893 R-DDI-72673 https://reactome.org/PathwayBrowser/#/R-DDI-72673 Release of 40S and 60S subunits from the 80S ribosome IEA Dictyostelium discoideum DDB_G0272893 R-DDI-927789 https://reactome.org/PathwayBrowser/#/R-DDI-927789 Formation of UPF1:eRF3 complex on mRNA with a premature termination codon and no Exon Junction Complex IEA Dictyostelium discoideum DDB_G0272893 R-DDI-927832 https://reactome.org/PathwayBrowser/#/R-DDI-927832 UPF1 binds an mRNP with a termination codon preceding an Exon Junction Complex IEA Dictyostelium discoideum DDB_G0272893 R-DDI-927889 https://reactome.org/PathwayBrowser/#/R-DDI-927889 SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex) IEA Dictyostelium discoideum DDB_G0272905 R-DDI-2214351 https://reactome.org/PathwayBrowser/#/R-DDI-2214351 PLK1 phosphorylates GORASP1 IEA Dictyostelium discoideum DDB_G0272905 R-DDI-5694409 https://reactome.org/PathwayBrowser/#/R-DDI-5694409 Nucleotide exchange on RAB1 IEA Dictyostelium discoideum DDB_G0272905 R-DDI-5694439 https://reactome.org/PathwayBrowser/#/R-DDI-5694439 COPII coat binds TRAPPCII and RAB1:GDP IEA Dictyostelium discoideum DDB_G0272905 R-DDI-5694441 https://reactome.org/PathwayBrowser/#/R-DDI-5694441 CSNK1D phosphorylates SEC23 IEA Dictyostelium discoideum DDB_G0272905 R-DDI-6807864 https://reactome.org/PathwayBrowser/#/R-DDI-6807864 RAB1:GTP recruits GBF1 to the ERGIC IEA Dictyostelium discoideum DDB_G0272905 R-DDI-6807866 https://reactome.org/PathwayBrowser/#/R-DDI-6807866 GBF1 recruits ARF:GDP to the ERGIC IEA Dictyostelium discoideum DDB_G0272905 R-DDI-6807868 https://reactome.org/PathwayBrowser/#/R-DDI-6807868 GBF1 stimulates ARF nucleotide exchange IEA Dictyostelium discoideum DDB_G0272905 R-DDI-6807872 https://reactome.org/PathwayBrowser/#/R-DDI-6807872 Active ARF recruits coatomer IEA Dictyostelium discoideum DDB_G0272905 R-DDI-6807875 https://reactome.org/PathwayBrowser/#/R-DDI-6807875 ARFGAP, cargo, v-SNAREs and p24 proteins bind nascent COPI complex IEA Dictyostelium discoideum DDB_G0272905 R-DDI-6807877 https://reactome.org/PathwayBrowser/#/R-DDI-6807877 ARFGAPs stimulate ARF GTPase activity IEA Dictyostelium discoideum DDB_G0272905 R-DDI-6809003 https://reactome.org/PathwayBrowser/#/R-DDI-6809003 ERGIC-to-Golgi vesicles bind dynein:dynactin IEA Dictyostelium discoideum DDB_G0272905 R-DDI-6809011 https://reactome.org/PathwayBrowser/#/R-DDI-6809011 cis-Golgi t-SNAREs bind YKT6 on tethered vesicle IEA Dictyostelium discoideum DDB_G0272905 R-DDI-6811411 https://reactome.org/PathwayBrowser/#/R-DDI-6811411 GBF1 recruits ARF:GDP to the Golgi IEA Dictyostelium discoideum DDB_G0272905 R-DDI-6811412 https://reactome.org/PathwayBrowser/#/R-DDI-6811412 Active ARF recruits coatomer to the Golgi IEA Dictyostelium discoideum DDB_G0272905 R-DDI-6811414 https://reactome.org/PathwayBrowser/#/R-DDI-6811414 GBF1 stimulates nucleotide exchange on ARF IEA Dictyostelium discoideum DDB_G0272905 R-DDI-6811415 https://reactome.org/PathwayBrowser/#/R-DDI-6811415 RAB:GTP recruits GBF1 to the Golgi membrane IEA Dictyostelium discoideum DDB_G0272905 R-DDI-6811417 https://reactome.org/PathwayBrowser/#/R-DDI-6811417 ARFGAP, cargo, vSNARES and p24 proteins bind COPI vesicles at Golgi IEA Dictyostelium discoideum DDB_G0272905 R-DDI-6811418 https://reactome.org/PathwayBrowser/#/R-DDI-6811418 ARFGAPs stimulate ARF GTPase activity at the Golgi membrane IEA Dictyostelium discoideum DDB_G0272905 R-DDI-6811427 https://reactome.org/PathwayBrowser/#/R-DDI-6811427 COPI vesicle uncoating at the ER IEA Dictyostelium discoideum DDB_G0272905 R-DDI-6814831 https://reactome.org/PathwayBrowser/#/R-DDI-6814831 TBC1D20 binds RAB1:GTP IEA Dictyostelium discoideum DDB_G0272905 R-DDI-6814833 https://reactome.org/PathwayBrowser/#/R-DDI-6814833 TBC1D20 stimulates GTPase activity of RAB1, resulting in hydrolysis of GTP IEA Dictyostelium discoideum DDB_G0272905 R-DDI-8847534 https://reactome.org/PathwayBrowser/#/R-DDI-8847534 RAB43 hydrolyses GTP IEA Dictyostelium discoideum DDB_G0272905 R-DDI-8847537 https://reactome.org/PathwayBrowser/#/R-DDI-8847537 RAB43:GTP binds USP8NL IEA Dictyostelium discoideum DDB_G0272905 R-DDI-8870466 https://reactome.org/PathwayBrowser/#/R-DDI-8870466 RGGT:CHM binds RABs IEA Dictyostelium discoideum DDB_G0272905 R-DDI-8870469 https://reactome.org/PathwayBrowser/#/R-DDI-8870469 RGGT geranylgeranylates RAB proteins IEA Dictyostelium discoideum DDB_G0272905 R-DDI-8877475 https://reactome.org/PathwayBrowser/#/R-DDI-8877475 TRAPPC complexes exchange GTP for GDP on RAB1 IEA Dictyostelium discoideum DDB_G0272931 R-DDI-1955380 https://reactome.org/PathwayBrowser/#/R-DDI-1955380 TIMM9:TIMM10 transfers proteins to TIMM22 IEA Dictyostelium discoideum DDB_G0272935 R-DDI-947499 https://reactome.org/PathwayBrowser/#/R-DDI-947499 Exchange of oxygen with sulfur in MoCo IEA Dictyostelium discoideum DDB_G0272951 R-DDI-9907976 https://reactome.org/PathwayBrowser/#/R-DDI-9907976 PSMD5 and PSMD2 bind PSMC2:PSMC1 IEA Dictyostelium discoideum DDB_G0272951 R-DDI-9907980 https://reactome.org/PathwayBrowser/#/R-DDI-9907980 Formation of the 19S regulatory particle base precursor IEA Dictyostelium discoideum DDB_G0272951 R-DDI-9908026 https://reactome.org/PathwayBrowser/#/R-DDI-9908026 Formation of the 19S regulatory particle precursor IEA Dictyostelium discoideum DDB_G0272951 R-DDI-9908178 https://reactome.org/PathwayBrowser/#/R-DDI-9908178 Formation of the 26S proteasome IEA Dictyostelium discoideum DDB_G0272975 R-DDI-5635854 https://reactome.org/PathwayBrowser/#/R-DDI-5635854 GLI2,3 are degraded by the proteasome IEA Dictyostelium discoideum DDB_G0272975 R-DDI-5635856 https://reactome.org/PathwayBrowser/#/R-DDI-5635856 SPOP:CUL3:RBX1 ubiquitinates GLI2,3 IEA Dictyostelium discoideum DDB_G0272975 R-DDI-9706390 https://reactome.org/PathwayBrowser/#/R-DDI-9706390 RHOBTB3 binds interacting proteins at trans-Golgi network IEA Dictyostelium discoideum DDB_G0272975 R-DDI-9706393 https://reactome.org/PathwayBrowser/#/R-DDI-9706393 RHOBTB3 binds ATP IEA Dictyostelium discoideum DDB_G0272975 R-DDI-9706399 https://reactome.org/PathwayBrowser/#/R-DDI-9706399 RHOBTB3 hydrolyzes ATP IEA Dictyostelium discoideum DDB_G0272991 R-DDI-265177 https://reactome.org/PathwayBrowser/#/R-DDI-265177 Exocyst complex formation IEA Dictyostelium discoideum DDB_G0272997 R-DDI-6791227 https://reactome.org/PathwayBrowser/#/R-DDI-6791227 47S pre-rRNA is nucleolytically processed at A' (01,A1), site A0, and site 02 (site 6) to yield 45S pre-rRNA IEA Dictyostelium discoideum DDB_G0273003 R-DDI-111437 https://reactome.org/PathwayBrowser/#/R-DDI-111437 Cleavage of the 3'-end of the Histone Pre-mRNA IEA Dictyostelium discoideum DDB_G0273003 R-DDI-111438 https://reactome.org/PathwayBrowser/#/R-DDI-111438 Recruitment of U7 snRNP:ZFP100 complex to the Histone Pre-mRNA IEA Dictyostelium discoideum DDB_G0273003 R-DDI-77585 https://reactome.org/PathwayBrowser/#/R-DDI-77585 Recruitment of U7 snRNP:ZFP100 complex to the SLBP Bound Pre-mRNA IEA Dictyostelium discoideum DDB_G0273003 R-DDI-77586 https://reactome.org/PathwayBrowser/#/R-DDI-77586 Cleavage of the 3'-end of Replication Dependent Histone Pre-mRNA IEA Dictyostelium discoideum DDB_G0273003 R-DDI-9770236 https://reactome.org/PathwayBrowser/#/R-DDI-9770236 Formation of the Spliceosomal P complex and exon ligation IEA Dictyostelium discoideum DDB_G0273031 R-DDI-6814153 https://reactome.org/PathwayBrowser/#/R-DDI-6814153 ADO oxidises 2AET to HTAU IEA Dictyostelium discoideum DDB_G0273033 R-DDI-418582 https://reactome.org/PathwayBrowser/#/R-DDI-418582 G alpha (q) auto-inactivates by hydrolysing GTP to GDP IEA Dictyostelium discoideum DDB_G0273033 R-DDI-8981892 https://reactome.org/PathwayBrowser/#/R-DDI-8981892 Active G alpha (z) binds RGS proteins IEA Dictyostelium discoideum DDB_G0273033 R-DDI-8982012 https://reactome.org/PathwayBrowser/#/R-DDI-8982012 G alpha (i):RGS dissociates to inactive G alpha (i)–i1/i2/i3 IEA Dictyostelium discoideum DDB_G0273033 R-DDI-8982017 https://reactome.org/PathwayBrowser/#/R-DDI-8982017 Active G alpha (q) binds RGS proteins IEA Dictyostelium discoideum DDB_G0273033 R-DDI-8982018 https://reactome.org/PathwayBrowser/#/R-DDI-8982018 G alpha (z):RGS complex dissociates to give inactive G alpha (z) IEA Dictyostelium discoideum DDB_G0273033 R-DDI-8982019 https://reactome.org/PathwayBrowser/#/R-DDI-8982019 Active G alpha (i)–i1/i2/i3 binds RGS proteins IEA Dictyostelium discoideum DDB_G0273033 R-DDI-8982020 https://reactome.org/PathwayBrowser/#/R-DDI-8982020 G alpha (i)–i1/i2/i3 in G (i):RGS complex is inactivated IEA Dictyostelium discoideum DDB_G0273033 R-DDI-8982021 https://reactome.org/PathwayBrowser/#/R-DDI-8982021 G alpha (z) in G alpha (z):RGS complex is inactivated IEA Dictyostelium discoideum DDB_G0273033 R-DDI-8982025 https://reactome.org/PathwayBrowser/#/R-DDI-8982025 G alpha (q) in G (q):RGS complex is inactivated IEA Dictyostelium discoideum DDB_G0273033 R-DDI-8982026 https://reactome.org/PathwayBrowser/#/R-DDI-8982026 G alpha (q):RGS dissociates to inactive G alpha (q) IEA Dictyostelium discoideum DDB_G0273045 R-DDI-143468 https://reactome.org/PathwayBrowser/#/R-DDI-143468 MEOS oxidizes ethanol to acetaldehyde IEA Dictyostelium discoideum DDB_G0273045 R-DDI-156526 https://reactome.org/PathwayBrowser/#/R-DDI-156526 CYP1A2,3A4,3A5,2A13 oxidise AFB1 to AFXBO IEA Dictyostelium discoideum DDB_G0273045 R-DDI-211874 https://reactome.org/PathwayBrowser/#/R-DDI-211874 CYP2S1 4-hydroxylates atRA IEA Dictyostelium discoideum DDB_G0273045 R-DDI-211881 https://reactome.org/PathwayBrowser/#/R-DDI-211881 Coumarin is 7-hydroxylated by CYP2A13 IEA Dictyostelium discoideum DDB_G0273045 R-DDI-211910 https://reactome.org/PathwayBrowser/#/R-DDI-211910 CYP2C8 inactivates paclitaxel by 6alpha-hydroxylation IEA Dictyostelium discoideum DDB_G0273045 R-DDI-211929 https://reactome.org/PathwayBrowser/#/R-DDI-211929 CYP2C19 5-hydroxylates omeprazole IEA Dictyostelium discoideum DDB_G0273045 R-DDI-211960 https://reactome.org/PathwayBrowser/#/R-DDI-211960 CYP2U1 19-hydroxylates ARA IEA Dictyostelium discoideum DDB_G0273045 R-DDI-211966 https://reactome.org/PathwayBrowser/#/R-DDI-211966 CYP2D6 4-hydroxylates debrisoquine IEA Dictyostelium discoideum DDB_G0273045 R-DDI-211968 https://reactome.org/PathwayBrowser/#/R-DDI-211968 CYP2W1 oxidises INDOL IEA Dictyostelium discoideum DDB_G0273045 R-DDI-211983 https://reactome.org/PathwayBrowser/#/R-DDI-211983 CYP2J2 oxidises ARA IEA Dictyostelium discoideum DDB_G0273045 R-DDI-211988 https://reactome.org/PathwayBrowser/#/R-DDI-211988 CYP2C9 inactivates tolbutamide by 4methyl-hydroxylation IEA Dictyostelium discoideum DDB_G0273045 R-DDI-211991 https://reactome.org/PathwayBrowser/#/R-DDI-211991 Cyclophosphamide is 4-hydroxylated by CYP2B6 IEA Dictyostelium discoideum DDB_G0273045 R-DDI-212004 https://reactome.org/PathwayBrowser/#/R-DDI-212004 CYP2C18 initiates bioactivation of phenytoin by 4-hydroxylation IEA Dictyostelium discoideum DDB_G0273045 R-DDI-212005 https://reactome.org/PathwayBrowser/#/R-DDI-212005 CYP2F1 dehydrogenates 3-methylindole IEA Dictyostelium discoideum DDB_G0273045 R-DDI-2161814 https://reactome.org/PathwayBrowser/#/R-DDI-2161814 Arachidonate is hydroxylated to 19-HETE by CYP(2) IEA Dictyostelium discoideum DDB_G0273045 R-DDI-2161890 https://reactome.org/PathwayBrowser/#/R-DDI-2161890 Arachidonate is epoxidated to 5,6-EET by CYP(4) IEA Dictyostelium discoideum DDB_G0273045 R-DDI-2161899 https://reactome.org/PathwayBrowser/#/R-DDI-2161899 Arachidonate is epoxidated to 8,9-EET by CYP(5) IEA Dictyostelium discoideum DDB_G0273045 R-DDI-2161940 https://reactome.org/PathwayBrowser/#/R-DDI-2161940 Arachidonate is hydroxylated to 20-HETE by CYP(3) IEA Dictyostelium discoideum DDB_G0273045 R-DDI-5423647 https://reactome.org/PathwayBrowser/#/R-DDI-5423647 CYP2A13 oxidises AFM1 to AFM1E IEA Dictyostelium discoideum DDB_G0273045 R-DDI-76354 https://reactome.org/PathwayBrowser/#/R-DDI-76354 Vinyl chloride is oxidized to 2-Chloroethylene oxide IEA Dictyostelium discoideum DDB_G0273045 R-DDI-76397 https://reactome.org/PathwayBrowser/#/R-DDI-76397 Acetaminophen oxidised to N-acetylbenzoquinoneimine (NAPQI) IEA Dictyostelium discoideum DDB_G0273045 R-DDI-76416 https://reactome.org/PathwayBrowser/#/R-DDI-76416 Benzene is hydroxylated to phenol IEA Dictyostelium discoideum DDB_G0273045 R-DDI-76434 https://reactome.org/PathwayBrowser/#/R-DDI-76434 Dehalogenation of carbon tetrachloride to form a free radical IEA Dictyostelium discoideum DDB_G0273045 R-DDI-76453 https://reactome.org/PathwayBrowser/#/R-DDI-76453 Coumarin is 7-hydroxylated by CYP2A6 IEA Dictyostelium discoideum DDB_G0273045 R-DDI-76456 https://reactome.org/PathwayBrowser/#/R-DDI-76456 O-atom dealkylation of dextromethorphan IEA Dictyostelium discoideum DDB_G0273045 R-DDI-76475 https://reactome.org/PathwayBrowser/#/R-DDI-76475 Dehalogenation of the poly-halogenated hydrocarbon Halothane to form the acylhalide Trifluoroacetlychloride and hydrogen bromide IEA Dictyostelium discoideum DDB_G0273045 R-DDI-9027043 https://reactome.org/PathwayBrowser/#/R-DDI-9027043 CYPs hydroxylate DHA to 14(R)-HDHA IEA Dictyostelium discoideum DDB_G0273045 R-DDI-9027302 https://reactome.org/PathwayBrowser/#/R-DDI-9027302 CYP2E1 oxidises 14(S)-HDHA to 14(S),21(R)-diHDHA and 14(S),21(S)-diHDHA IEA Dictyostelium discoideum DDB_G0273045 R-DDI-9027321 https://reactome.org/PathwayBrowser/#/R-DDI-9027321 CYP2E1 oxidises 14(R)-HDHA to 14(R),21(R)-diHDHA and 14(R),21(S)-diHDHA IEA Dictyostelium discoideum DDB_G0273045 R-DDI-9680865 https://reactome.org/PathwayBrowser/#/R-DDI-9680865 CYP3A4, CYP2B6 bind ritonavir IEA Dictyostelium discoideum DDB_G0273045 R-DDI-9749986 https://reactome.org/PathwayBrowser/#/R-DDI-9749986 CYP2,3 cytochromes hydroxylate ST to 2,3-DHBA IEA Dictyostelium discoideum DDB_G0273045 R-DDI-9750016 https://reactome.org/PathwayBrowser/#/R-DDI-9750016 CYP2,3 cytochromes hydroxylate ST to 2,5-DHBA IEA Dictyostelium discoideum DDB_G0273045 R-DDI-9753285 https://reactome.org/PathwayBrowser/#/R-DDI-9753285 CYP2E1 monooxygenates APAP to NAPQI IEA Dictyostelium discoideum DDB_G0273045 R-DDI-9915971 https://reactome.org/PathwayBrowser/#/R-DDI-9915971 Arachidonate is epoxidated to 11,12-EET by CYP(5) IEA Dictyostelium discoideum DDB_G0273045 R-DDI-9915997 https://reactome.org/PathwayBrowser/#/R-DDI-9915997 Arachidonate is epoxidated to 14,15-EET by CYP(5) IEA Dictyostelium discoideum DDB_G0273047 R-DDI-143468 https://reactome.org/PathwayBrowser/#/R-DDI-143468 MEOS oxidizes ethanol to acetaldehyde IEA Dictyostelium discoideum DDB_G0273047 R-DDI-156526 https://reactome.org/PathwayBrowser/#/R-DDI-156526 CYP1A2,3A4,3A5,2A13 oxidise AFB1 to AFXBO IEA Dictyostelium discoideum DDB_G0273047 R-DDI-211874 https://reactome.org/PathwayBrowser/#/R-DDI-211874 CYP2S1 4-hydroxylates atRA IEA Dictyostelium discoideum DDB_G0273047 R-DDI-211881 https://reactome.org/PathwayBrowser/#/R-DDI-211881 Coumarin is 7-hydroxylated by CYP2A13 IEA Dictyostelium discoideum DDB_G0273047 R-DDI-211910 https://reactome.org/PathwayBrowser/#/R-DDI-211910 CYP2C8 inactivates paclitaxel by 6alpha-hydroxylation IEA Dictyostelium discoideum DDB_G0273047 R-DDI-211929 https://reactome.org/PathwayBrowser/#/R-DDI-211929 CYP2C19 5-hydroxylates omeprazole IEA Dictyostelium discoideum DDB_G0273047 R-DDI-211960 https://reactome.org/PathwayBrowser/#/R-DDI-211960 CYP2U1 19-hydroxylates ARA IEA Dictyostelium discoideum DDB_G0273047 R-DDI-211966 https://reactome.org/PathwayBrowser/#/R-DDI-211966 CYP2D6 4-hydroxylates debrisoquine IEA Dictyostelium discoideum DDB_G0273047 R-DDI-211968 https://reactome.org/PathwayBrowser/#/R-DDI-211968 CYP2W1 oxidises INDOL IEA Dictyostelium discoideum DDB_G0273047 R-DDI-211983 https://reactome.org/PathwayBrowser/#/R-DDI-211983 CYP2J2 oxidises ARA IEA Dictyostelium discoideum DDB_G0273047 R-DDI-211988 https://reactome.org/PathwayBrowser/#/R-DDI-211988 CYP2C9 inactivates tolbutamide by 4methyl-hydroxylation IEA Dictyostelium discoideum DDB_G0273047 R-DDI-211991 https://reactome.org/PathwayBrowser/#/R-DDI-211991 Cyclophosphamide is 4-hydroxylated by CYP2B6 IEA Dictyostelium discoideum DDB_G0273047 R-DDI-212004 https://reactome.org/PathwayBrowser/#/R-DDI-212004 CYP2C18 initiates bioactivation of phenytoin by 4-hydroxylation IEA Dictyostelium discoideum DDB_G0273047 R-DDI-212005 https://reactome.org/PathwayBrowser/#/R-DDI-212005 CYP2F1 dehydrogenates 3-methylindole IEA Dictyostelium discoideum DDB_G0273047 R-DDI-2161814 https://reactome.org/PathwayBrowser/#/R-DDI-2161814 Arachidonate is hydroxylated to 19-HETE by CYP(2) IEA Dictyostelium discoideum DDB_G0273047 R-DDI-2161890 https://reactome.org/PathwayBrowser/#/R-DDI-2161890 Arachidonate is epoxidated to 5,6-EET by CYP(4) IEA Dictyostelium discoideum DDB_G0273047 R-DDI-2161899 https://reactome.org/PathwayBrowser/#/R-DDI-2161899 Arachidonate is epoxidated to 8,9-EET by CYP(5) IEA Dictyostelium discoideum DDB_G0273047 R-DDI-2161940 https://reactome.org/PathwayBrowser/#/R-DDI-2161940 Arachidonate is hydroxylated to 20-HETE by CYP(3) IEA Dictyostelium discoideum DDB_G0273047 R-DDI-5423647 https://reactome.org/PathwayBrowser/#/R-DDI-5423647 CYP2A13 oxidises AFM1 to AFM1E IEA Dictyostelium discoideum DDB_G0273047 R-DDI-76354 https://reactome.org/PathwayBrowser/#/R-DDI-76354 Vinyl chloride is oxidized to 2-Chloroethylene oxide IEA Dictyostelium discoideum DDB_G0273047 R-DDI-76397 https://reactome.org/PathwayBrowser/#/R-DDI-76397 Acetaminophen oxidised to N-acetylbenzoquinoneimine (NAPQI) IEA Dictyostelium discoideum DDB_G0273047 R-DDI-76416 https://reactome.org/PathwayBrowser/#/R-DDI-76416 Benzene is hydroxylated to phenol IEA Dictyostelium discoideum DDB_G0273047 R-DDI-76434 https://reactome.org/PathwayBrowser/#/R-DDI-76434 Dehalogenation of carbon tetrachloride to form a free radical IEA Dictyostelium discoideum DDB_G0273047 R-DDI-76453 https://reactome.org/PathwayBrowser/#/R-DDI-76453 Coumarin is 7-hydroxylated by CYP2A6 IEA Dictyostelium discoideum DDB_G0273047 R-DDI-76456 https://reactome.org/PathwayBrowser/#/R-DDI-76456 O-atom dealkylation of dextromethorphan IEA Dictyostelium discoideum DDB_G0273047 R-DDI-76475 https://reactome.org/PathwayBrowser/#/R-DDI-76475 Dehalogenation of the poly-halogenated hydrocarbon Halothane to form the acylhalide Trifluoroacetlychloride and hydrogen bromide IEA Dictyostelium discoideum DDB_G0273047 R-DDI-9027043 https://reactome.org/PathwayBrowser/#/R-DDI-9027043 CYPs hydroxylate DHA to 14(R)-HDHA IEA Dictyostelium discoideum DDB_G0273047 R-DDI-9027302 https://reactome.org/PathwayBrowser/#/R-DDI-9027302 CYP2E1 oxidises 14(S)-HDHA to 14(S),21(R)-diHDHA and 14(S),21(S)-diHDHA IEA Dictyostelium discoideum DDB_G0273047 R-DDI-9027321 https://reactome.org/PathwayBrowser/#/R-DDI-9027321 CYP2E1 oxidises 14(R)-HDHA to 14(R),21(R)-diHDHA and 14(R),21(S)-diHDHA IEA Dictyostelium discoideum DDB_G0273047 R-DDI-9680865 https://reactome.org/PathwayBrowser/#/R-DDI-9680865 CYP3A4, CYP2B6 bind ritonavir IEA Dictyostelium discoideum DDB_G0273047 R-DDI-9749986 https://reactome.org/PathwayBrowser/#/R-DDI-9749986 CYP2,3 cytochromes hydroxylate ST to 2,3-DHBA IEA Dictyostelium discoideum DDB_G0273047 R-DDI-9750016 https://reactome.org/PathwayBrowser/#/R-DDI-9750016 CYP2,3 cytochromes hydroxylate ST to 2,5-DHBA IEA Dictyostelium discoideum DDB_G0273047 R-DDI-9753285 https://reactome.org/PathwayBrowser/#/R-DDI-9753285 CYP2E1 monooxygenates APAP to NAPQI IEA Dictyostelium discoideum DDB_G0273047 R-DDI-9915971 https://reactome.org/PathwayBrowser/#/R-DDI-9915971 Arachidonate is epoxidated to 11,12-EET by CYP(5) IEA Dictyostelium discoideum DDB_G0273047 R-DDI-9915997 https://reactome.org/PathwayBrowser/#/R-DDI-9915997 Arachidonate is epoxidated to 14,15-EET by CYP(5) IEA Dictyostelium discoideum DDB_G0273059 R-DDI-5694441 https://reactome.org/PathwayBrowser/#/R-DDI-5694441 CSNK1D phosphorylates SEC23 IEA Dictyostelium discoideum DDB_G0273069 R-DDI-482619 https://reactome.org/PathwayBrowser/#/R-DDI-482619 (d)NDP + ATP <=> (d)NTP + ADP (NME1,2,3) IEA Dictyostelium discoideum DDB_G0273069 R-DDI-482621 https://reactome.org/PathwayBrowser/#/R-DDI-482621 (d)NTP + ADP <=> (d)NDP + ATP (NME1,2,3) IEA Dictyostelium discoideum DDB_G0273069 R-DDI-482804 https://reactome.org/PathwayBrowser/#/R-DDI-482804 (d)NDP + ATP <=> (d)NTP + ADP (NME4) IEA Dictyostelium discoideum DDB_G0273069 R-DDI-482812 https://reactome.org/PathwayBrowser/#/R-DDI-482812 (d)NTP + ADP <=> (d)NDP + ATP (NME4) IEA Dictyostelium discoideum DDB_G0273069 R-DDI-6798748 https://reactome.org/PathwayBrowser/#/R-DDI-6798748 Exocytosis of secretory granule lumen proteins IEA Dictyostelium discoideum DDB_G0273069 R-DDI-6800434 https://reactome.org/PathwayBrowser/#/R-DDI-6800434 Exocytosis of ficolin-rich granule lumen proteins IEA Dictyostelium discoideum DDB_G0273069 R-DDI-6806877 https://reactome.org/PathwayBrowser/#/R-DDI-6806877 NME1:NME3 heterohexamer, NME2P1 phosphorylate NDPs to NTPs IEA Dictyostelium discoideum DDB_G0273069 R-DDI-9748969 https://reactome.org/PathwayBrowser/#/R-DDI-9748969 NME1:2 hexamer phosphorylates 6TdGDP to 6TdGTP IEA Dictyostelium discoideum DDB_G0273069 R-DDI-9748999 https://reactome.org/PathwayBrowser/#/R-DDI-9748999 NME1:2 hexamer phosphorylates 6TGDP to 6TGTP IEA Dictyostelium discoideum DDB_G0273069 R-DDI-9755013 https://reactome.org/PathwayBrowser/#/R-DDI-9755013 NME1,2 hexamers phosphorylate RBV-DP IEA Dictyostelium discoideum DDB_G0273071 R-DDI-1222516 https://reactome.org/PathwayBrowser/#/R-DDI-1222516 Intraphagosomal pH is lowered to 5 by V-ATPase IEA Dictyostelium discoideum DDB_G0273071 R-DDI-74723 https://reactome.org/PathwayBrowser/#/R-DDI-74723 Endosome acidification IEA Dictyostelium discoideum DDB_G0273071 R-DDI-917841 https://reactome.org/PathwayBrowser/#/R-DDI-917841 Acidification of Tf:TfR1 containing endosome IEA Dictyostelium discoideum DDB_G0273071 R-DDI-9639286 https://reactome.org/PathwayBrowser/#/R-DDI-9639286 RRAGC,D exchanges GTP for GDP IEA Dictyostelium discoideum DDB_G0273071 R-DDI-9640167 https://reactome.org/PathwayBrowser/#/R-DDI-9640167 RRAGA,B exchanges GDP for GTP IEA Dictyostelium discoideum DDB_G0273071 R-DDI-9640195 https://reactome.org/PathwayBrowser/#/R-DDI-9640195 RRAGA,B hydrolyzes GTP IEA Dictyostelium discoideum DDB_G0273071 R-DDI-9645598 https://reactome.org/PathwayBrowser/#/R-DDI-9645598 RRAGC,D hydrolyzes GTP IEA Dictyostelium discoideum DDB_G0273071 R-DDI-9645608 https://reactome.org/PathwayBrowser/#/R-DDI-9645608 v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP binds mTORC1 IEA Dictyostelium discoideum DDB_G0273071 R-DDI-9646468 https://reactome.org/PathwayBrowser/#/R-DDI-9646468 mTORC1 binds RHEB:GTP IEA Dictyostelium discoideum DDB_G0273095 R-DDI-6800434 https://reactome.org/PathwayBrowser/#/R-DDI-6800434 Exocytosis of ficolin-rich granule lumen proteins IEA Dictyostelium discoideum DDB_G0273097 R-DDI-6798743 https://reactome.org/PathwayBrowser/#/R-DDI-6798743 Exocytosis of secretory granule membrane proteins IEA Dictyostelium discoideum DDB_G0273097 R-DDI-6799350 https://reactome.org/PathwayBrowser/#/R-DDI-6799350 Exocytosis of specific granule membrane proteins IEA Dictyostelium discoideum DDB_G0273097 R-DDI-9635739 https://reactome.org/PathwayBrowser/#/R-DDI-9635739 PTPN7 dephosphorylates p-T,Y-MAPKs IEA Dictyostelium discoideum DDB_G0273097 R-DDI-9635743 https://reactome.org/PathwayBrowser/#/R-DDI-9635743 PTPN7 binds p-T,Y-MAPK IEA Dictyostelium discoideum DDB_G0273101 R-DDI-8847880 https://reactome.org/PathwayBrowser/#/R-DDI-8847880 CYTH proteins bind ARF1:GTP IEA Dictyostelium discoideum DDB_G0273101 R-DDI-8847883 https://reactome.org/PathwayBrowser/#/R-DDI-8847883 CYTH proteins stimulate ARF1 GTPase activity IEA Dictyostelium discoideum DDB_G0273105 R-DDI-5690565 https://reactome.org/PathwayBrowser/#/R-DDI-5690565 SCD desaturates ST-CoA to OLE-CoA IEA Dictyostelium discoideum DDB_G0273105 R-DDI-8847579 https://reactome.org/PathwayBrowser/#/R-DDI-8847579 SCD5 desaturates ST-CoA to OLE-CoA IEA Dictyostelium discoideum DDB_G0273107 R-DDI-482772 https://reactome.org/PathwayBrowser/#/R-DDI-482772 Release of platelet cytosolic components IEA Dictyostelium discoideum DDB_G0273107 R-DDI-6798748 https://reactome.org/PathwayBrowser/#/R-DDI-6798748 Exocytosis of secretory granule lumen proteins IEA Dictyostelium discoideum DDB_G0273107 R-DDI-6798749 https://reactome.org/PathwayBrowser/#/R-DDI-6798749 Exocytosis of specific granule lumen proteins IEA Dictyostelium discoideum DDB_G0273107 R-DDI-6800434 https://reactome.org/PathwayBrowser/#/R-DDI-6800434 Exocytosis of ficolin-rich granule lumen proteins IEA Dictyostelium discoideum DDB_G0273125 R-DDI-5693578 https://reactome.org/PathwayBrowser/#/R-DDI-5693578 TDP1 and TDP2 process unligatable DSB ends IEA Dictyostelium discoideum DDB_G0273131 R-DDI-70377 https://reactome.org/PathwayBrowser/#/R-DDI-70377 alpha-D-glucose 6-phosphate + NADP+ => D-glucono-1,5-lactone 6-phosphate + NADPH + H+ IEA Dictyostelium discoideum DDB_G0273133 R-DDI-9013144 https://reactome.org/PathwayBrowser/#/R-DDI-9013144 RAC1 GAPs stimulate RAC1 GTPase activity IEA Dictyostelium discoideum DDB_G0273133 R-DDI-9013145 https://reactome.org/PathwayBrowser/#/R-DDI-9013145 RAC1 binds effectors at the plasma membrane IEA Dictyostelium discoideum DDB_G0273133 R-DDI-9013161 https://reactome.org/PathwayBrowser/#/R-DDI-9013161 CDC42 GAPs stimulate CDC42 GTPase activity IEA Dictyostelium discoideum DDB_G0273133 R-DDI-9014294 https://reactome.org/PathwayBrowser/#/R-DDI-9014294 RAC2 binds effectors at the plasma membrane IEA Dictyostelium discoideum DDB_G0273133 R-DDI-9014295 https://reactome.org/PathwayBrowser/#/R-DDI-9014295 RAC2 GAPs stimulate RAC2 GTPase activity IEA Dictyostelium discoideum DDB_G0273133 R-DDI-9014449 https://reactome.org/PathwayBrowser/#/R-DDI-9014449 RHOG binds effectors at the plasma membrane IEA Dictyostelium discoideum DDB_G0273133 R-DDI-9017488 https://reactome.org/PathwayBrowser/#/R-DDI-9017488 RHOJ GAPs stimulate RHOJ GTPase activity IEA Dictyostelium discoideum DDB_G0273133 R-DDI-9018745 https://reactome.org/PathwayBrowser/#/R-DDI-9018745 RHOQ GAPs stimulate RHOQ GTPase activity IEA Dictyostelium discoideum DDB_G0273133 R-DDI-9018746 https://reactome.org/PathwayBrowser/#/R-DDI-9018746 RHOQ binds effectors at the plasma membrane IEA Dictyostelium discoideum DDB_G0273133 R-DDI-9018766 https://reactome.org/PathwayBrowser/#/R-DDI-9018766 RHOU binds effectors at the plasma membrane IEA Dictyostelium discoideum DDB_G0273133 R-DDI-9018794 https://reactome.org/PathwayBrowser/#/R-DDI-9018794 RHOV binds effectors at the plasma membrane IEA Dictyostelium discoideum DDB_G0273133 R-DDI-9018806 https://reactome.org/PathwayBrowser/#/R-DDI-9018806 RAC3 GAPs stimulate RAC3 GTPase activity IEA Dictyostelium discoideum DDB_G0273133 R-DDI-9018808 https://reactome.org/PathwayBrowser/#/R-DDI-9018808 RAC3 binds effectors at the plasma membrane IEA Dictyostelium discoideum DDB_G0273141 R-DDI-983140 https://reactome.org/PathwayBrowser/#/R-DDI-983140 Transfer of Ub from E2 to substrate and release of E2 IEA Dictyostelium discoideum DDB_G0273141 R-DDI-983147 https://reactome.org/PathwayBrowser/#/R-DDI-983147 Release of E3 from polyubiquitinated substrate IEA Dictyostelium discoideum DDB_G0273141 R-DDI-983156 https://reactome.org/PathwayBrowser/#/R-DDI-983156 Polyubiquitination of substrate IEA Dictyostelium discoideum DDB_G0273141 R-DDI-983157 https://reactome.org/PathwayBrowser/#/R-DDI-983157 Interaction of E3 with substrate and E2-Ub complex IEA Dictyostelium discoideum DDB_G0273149 R-DDI-9710959 https://reactome.org/PathwayBrowser/#/R-DDI-9710959 p-STAT1 dimer binds KPNA1 IEA Dictyostelium discoideum DDB_G0273153 R-DDI-176054 https://reactome.org/PathwayBrowser/#/R-DDI-176054 GST dimers conjugate GSH with cytosolic substrates IEA Dictyostelium discoideum DDB_G0273153 R-DDI-3343700 https://reactome.org/PathwayBrowser/#/R-DDI-3343700 PRDX6:GSTP1 catalyzes 2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O IEA Dictyostelium discoideum DDB_G0273153 R-DDI-6798748 https://reactome.org/PathwayBrowser/#/R-DDI-6798748 Exocytosis of secretory granule lumen proteins IEA Dictyostelium discoideum DDB_G0273153 R-DDI-6800434 https://reactome.org/PathwayBrowser/#/R-DDI-6800434 Exocytosis of ficolin-rich granule lumen proteins IEA Dictyostelium discoideum DDB_G0273153 R-DDI-9663492 https://reactome.org/PathwayBrowser/#/R-DDI-9663492 BIL dissociates from GSTA1, FABP1 IEA Dictyostelium discoideum DDB_G0273153 R-DDI-9663511 https://reactome.org/PathwayBrowser/#/R-DDI-9663511 BIL binds GSTA1, FABP1 IEA Dictyostelium discoideum DDB_G0273153 R-DDI-9748996 https://reactome.org/PathwayBrowser/#/R-DDI-9748996 GST dimers cleave AZA to 6MP IEA Dictyostelium discoideum DDB_G0273153 R-DDI-9753280 https://reactome.org/PathwayBrowser/#/R-DDI-9753280 GSTs transfer GSH to NAPQI to form APAP-SG IEA Dictyostelium discoideum DDB_G0273163 R-DDI-1236970 https://reactome.org/PathwayBrowser/#/R-DDI-1236970 Proteasomal clevage of exogenous antigen (26S proteasome catalyst) IEA Dictyostelium discoideum DDB_G0273163 R-DDI-1504193 https://reactome.org/PathwayBrowser/#/R-DDI-1504193 Ubiquitinated DVL is degraded by the proteasome IEA Dictyostelium discoideum DDB_G0273163 R-DDI-174058 https://reactome.org/PathwayBrowser/#/R-DDI-174058 Degradation of multiubiquitinated Cdh1 IEA Dictyostelium discoideum DDB_G0273163 R-DDI-174105 https://reactome.org/PathwayBrowser/#/R-DDI-174105 Degradation of multiubiquitinated cell cycle proteins IEA Dictyostelium discoideum DDB_G0273163 R-DDI-174202 https://reactome.org/PathwayBrowser/#/R-DDI-174202 Degradation of multiubiquitinated Securin IEA Dictyostelium discoideum DDB_G0273163 R-DDI-188191 https://reactome.org/PathwayBrowser/#/R-DDI-188191 APC/C:Cdh1-mediated degradation of Skp2 IEA Dictyostelium discoideum DDB_G0273163 R-DDI-264458 https://reactome.org/PathwayBrowser/#/R-DDI-264458 Proteasome mediated degradation of COP1 IEA Dictyostelium discoideum DDB_G0273163 R-DDI-450466 https://reactome.org/PathwayBrowser/#/R-DDI-450466 AUF1:mRNA complex is destroyed IEA Dictyostelium discoideum DDB_G0273163 R-DDI-5635854 https://reactome.org/PathwayBrowser/#/R-DDI-5635854 GLI2,3 are degraded by the proteasome IEA Dictyostelium discoideum DDB_G0273163 R-DDI-5658430 https://reactome.org/PathwayBrowser/#/R-DDI-5658430 NF1 is degraded by the proteasome IEA Dictyostelium discoideum DDB_G0273163 R-DDI-5665854 https://reactome.org/PathwayBrowser/#/R-DDI-5665854 ADRM1:26S proteaseome binds UCHL5 IEA Dictyostelium discoideum DDB_G0273163 R-DDI-5665871 https://reactome.org/PathwayBrowser/#/R-DDI-5665871 ADRM1 binds 26S proteasome IEA Dictyostelium discoideum DDB_G0273163 R-DDI-5687112 https://reactome.org/PathwayBrowser/#/R-DDI-5687112 MAPK6 is degraded by the 26S proteasome IEA Dictyostelium discoideum DDB_G0273163 R-DDI-5689539 https://reactome.org/PathwayBrowser/#/R-DDI-5689539 ADRM1:26S proteaseome binds USP14 IEA Dictyostelium discoideum DDB_G0273163 R-DDI-68948 https://reactome.org/PathwayBrowser/#/R-DDI-68948 Ubiquitinated Orc1 is degraded by the proteasome IEA Dictyostelium discoideum DDB_G0273163 R-DDI-69016 https://reactome.org/PathwayBrowser/#/R-DDI-69016 Ubiquitinated Cdc6 is degraded by the proteasome IEA Dictyostelium discoideum DDB_G0273163 R-DDI-69600 https://reactome.org/PathwayBrowser/#/R-DDI-69600 Proteolytic degradation of ubiquitinated-Cdc25A IEA Dictyostelium discoideum DDB_G0273163 R-DDI-8850992 https://reactome.org/PathwayBrowser/#/R-DDI-8850992 Proteasome degrades polyubiquitinated PTEN IEA Dictyostelium discoideum DDB_G0273163 R-DDI-8854044 https://reactome.org/PathwayBrowser/#/R-DDI-8854044 Proteasome degrades AURKA ubiquitinated by SCF-FBXL7 IEA Dictyostelium discoideum DDB_G0273163 R-DDI-8866553 https://reactome.org/PathwayBrowser/#/R-DDI-8866553 misfolded CFTR is degraded by the 26S proteasome IEA Dictyostelium discoideum DDB_G0273163 R-DDI-9755306 https://reactome.org/PathwayBrowser/#/R-DDI-9755306 ub UBXN7 is degraded by the 26S proteasome IEA Dictyostelium discoideum DDB_G0273163 R-DDI-983150 https://reactome.org/PathwayBrowser/#/R-DDI-983150 Proteasomal cleavage of substrate IEA Dictyostelium discoideum DDB_G0273163 R-DDI-9907919 https://reactome.org/PathwayBrowser/#/R-DDI-9907919 Formation of the preholoproteasome IEA Dictyostelium discoideum DDB_G0273163 R-DDI-9907925 https://reactome.org/PathwayBrowser/#/R-DDI-9907925 Formation of the inner ring of the 20S immunoproteasome core particle IEA Dictyostelium discoideum DDB_G0273163 R-DDI-9907928 https://reactome.org/PathwayBrowser/#/R-DDI-9907928 Formation of the inner ring of the 20S thymoproteasome core particle IEA Dictyostelium discoideum DDB_G0273163 R-DDI-9907940 https://reactome.org/PathwayBrowser/#/R-DDI-9907940 Formation of the preholothymoproteasome IEA Dictyostelium discoideum DDB_G0273163 R-DDI-9907941 https://reactome.org/PathwayBrowser/#/R-DDI-9907941 Fromation of the preholoimmunoproteasome IEA Dictyostelium discoideum DDB_G0273163 R-DDI-9908178 https://reactome.org/PathwayBrowser/#/R-DDI-9908178 Formation of the 26S proteasome IEA Dictyostelium discoideum DDB_G0273163 R-DDI-9908709 https://reactome.org/PathwayBrowser/#/R-DDI-9908709 Formation of the PA28-alpha-beta-20S proteasome IEA Dictyostelium discoideum DDB_G0273163 R-DDI-9908721 https://reactome.org/PathwayBrowser/#/R-DDI-9908721 Formation of the PA28gamma-20S proteasome IEA Dictyostelium discoideum DDB_G0273195 R-DDI-352158 https://reactome.org/PathwayBrowser/#/R-DDI-352158 SLC16A10-mediated uptake of aromatic amino acids IEA Dictyostelium discoideum DDB_G0273195 R-DDI-879575 https://reactome.org/PathwayBrowser/#/R-DDI-879575 SLCOs, SLC16A2 transport T3,T4 from extracellular region to cytosol IEA Dictyostelium discoideum DDB_G0273199 R-DDI-203797 https://reactome.org/PathwayBrowser/#/R-DDI-203797 ERKs are inactivated by dual-specific phosphatases (DUSPs) IEA Dictyostelium discoideum DDB_G0273199 R-DDI-5675373 https://reactome.org/PathwayBrowser/#/R-DDI-5675373 Nuclear DUSPs dephosphorylate MAPKs IEA Dictyostelium discoideum DDB_G0273199 R-DDI-5675376 https://reactome.org/PathwayBrowser/#/R-DDI-5675376 Cytosolic DUSPs dephosphorylate MAPKs IEA Dictyostelium discoideum DDB_G0273201 R-DDI-141423 https://reactome.org/PathwayBrowser/#/R-DDI-141423 Binding of the MCC complex to the APC/C complex IEA Dictyostelium discoideum DDB_G0273201 R-DDI-141429 https://reactome.org/PathwayBrowser/#/R-DDI-141429 Inactivation of APC/C via CDC20 sequestration IEA Dictyostelium discoideum DDB_G0273201 R-DDI-141437 https://reactome.org/PathwayBrowser/#/R-DDI-141437 Formation of the MCC complex IEA Dictyostelium discoideum DDB_G0273201 R-DDI-174104 https://reactome.org/PathwayBrowser/#/R-DDI-174104 Ubiquitination of Cyclin A by APC/C:Cdc20 complex IEA Dictyostelium discoideum DDB_G0273201 R-DDI-174238 https://reactome.org/PathwayBrowser/#/R-DDI-174238 Activation of APC/C:Cdc20 by dissociation of Cdc20:phospho-APC/C from Cdc20:phospho-APC/C:Mad2:Bub3:BubR1 IEA Dictyostelium discoideum DDB_G0273201 R-DDI-179410 https://reactome.org/PathwayBrowser/#/R-DDI-179410 Association of Nek2A with MCC:APC/C IEA Dictyostelium discoideum DDB_G0273201 R-DDI-179417 https://reactome.org/PathwayBrowser/#/R-DDI-179417 Multiubiquitination of Nek2A IEA Dictyostelium discoideum DDB_G0273201 R-DDI-179421 https://reactome.org/PathwayBrowser/#/R-DDI-179421 Degradation of multiubiquitinated Nek2A IEA Dictyostelium discoideum DDB_G0273203 R-DDI-3215448 https://reactome.org/PathwayBrowser/#/R-DDI-3215448 SWI/SNF chromatin remodelling complex enhances MEP50:PRMT5 methyltransferase activity IEA Dictyostelium discoideum DDB_G0273203 R-DDI-5205799 https://reactome.org/PathwayBrowser/#/R-DDI-5205799 CCND1:CDK4:PRMT5:pT5-WDR77 methylates arginine-9 of histone H3 (H3R8) IEA Dictyostelium discoideum DDB_G0273207 R-DDI-112430 https://reactome.org/PathwayBrowser/#/R-DDI-112430 Formation of P-TEFb complex IEA Dictyostelium discoideum DDB_G0273207 R-DDI-6797090 https://reactome.org/PathwayBrowser/#/R-DDI-6797090 CCNK binds CDK12 IEA Dictyostelium discoideum DDB_G0273207 R-DDI-6797100 https://reactome.org/PathwayBrowser/#/R-DDI-6797100 CCNK binds CDK13 IEA Dictyostelium discoideum DDB_G0273207 R-DDI-6797606 https://reactome.org/PathwayBrowser/#/R-DDI-6797606 CDK12 phosphorylates RNA Pol II CTD at DNA repair genes IEA Dictyostelium discoideum DDB_G0273207 R-DDI-6797616 https://reactome.org/PathwayBrowser/#/R-DDI-6797616 CCNK:CDK12 binds RNA Pol II at DNA repair genes IEA Dictyostelium discoideum DDB_G0273207 R-DDI-6800434 https://reactome.org/PathwayBrowser/#/R-DDI-6800434 Exocytosis of ficolin-rich granule lumen proteins IEA Dictyostelium discoideum DDB_G0273207 R-DDI-6810233 https://reactome.org/PathwayBrowser/#/R-DDI-6810233 CDK7 phosphorylates serine-5 and serine-7 of heptad repeats in C-terminal domain of RNA polymerase II at snRNA promoter IEA Dictyostelium discoideum DDB_G0273207 R-DDI-6810238 https://reactome.org/PathwayBrowser/#/R-DDI-6810238 RNA polymerase II binds initiation factors at promoter of snRNA gene (U1, U2, U4, U4atac, U5, U11, U12) IEA Dictyostelium discoideum DDB_G0273207 R-DDI-6814555 https://reactome.org/PathwayBrowser/#/R-DDI-6814555 Integrator complex processes the 3' end of snRNA IEA Dictyostelium discoideum DDB_G0273207 R-DDI-6814559 https://reactome.org/PathwayBrowser/#/R-DDI-6814559 Pre-snRNA is elongated and capped with 7-methylguanosine IEA Dictyostelium discoideum DDB_G0273207 R-DDI-9012319 https://reactome.org/PathwayBrowser/#/R-DDI-9012319 p-TEFb phosphorylates serine 2 in RNA polymerase II CTD IEA Dictyostelium discoideum DDB_G0273209 R-DDI-5694409 https://reactome.org/PathwayBrowser/#/R-DDI-5694409 Nucleotide exchange on RAB1 IEA Dictyostelium discoideum DDB_G0273209 R-DDI-5694439 https://reactome.org/PathwayBrowser/#/R-DDI-5694439 COPII coat binds TRAPPCII and RAB1:GDP IEA Dictyostelium discoideum DDB_G0273209 R-DDI-5694441 https://reactome.org/PathwayBrowser/#/R-DDI-5694441 CSNK1D phosphorylates SEC23 IEA Dictyostelium discoideum DDB_G0273209 R-DDI-8877475 https://reactome.org/PathwayBrowser/#/R-DDI-8877475 TRAPPC complexes exchange GTP for GDP on RAB1 IEA Dictyostelium discoideum DDB_G0273249 R-DDI-3371422 https://reactome.org/PathwayBrowser/#/R-DDI-3371422 ATP hydrolysis by HSP70 IEA Dictyostelium discoideum DDB_G0273249 R-DDI-3371503 https://reactome.org/PathwayBrowser/#/R-DDI-3371503 STIP1(HOP) binds HSP90 and HSP70:HSP40:nascent protein IEA Dictyostelium discoideum DDB_G0273249 R-DDI-3371590 https://reactome.org/PathwayBrowser/#/R-DDI-3371590 HSP70 binds to HSP40:nascent protein IEA Dictyostelium discoideum DDB_G0273249 R-DDI-450580 https://reactome.org/PathwayBrowser/#/R-DDI-450580 AUF1 (hnRNP D0) is ubiquitinylated IEA Dictyostelium discoideum DDB_G0273249 R-DDI-5082356 https://reactome.org/PathwayBrowser/#/R-DDI-5082356 HSF1-mediated gene expression IEA Dictyostelium discoideum DDB_G0273249 R-DDI-5251942 https://reactome.org/PathwayBrowser/#/R-DDI-5251942 Hikeshi binds HSP70s:ATP IEA Dictyostelium discoideum DDB_G0273249 R-DDI-5251955 https://reactome.org/PathwayBrowser/#/R-DDI-5251955 HSP40s activate intrinsic ATPase activity of HSP70s in the nucleoplasm IEA Dictyostelium discoideum DDB_G0273249 R-DDI-5251959 https://reactome.org/PathwayBrowser/#/R-DDI-5251959 HSP40s activate intrinsic ATPase activity of HSP70s in the cytosol IEA Dictyostelium discoideum DDB_G0273249 R-DDI-5252079 https://reactome.org/PathwayBrowser/#/R-DDI-5252079 HSP110s exchange ATP for ADP on HSP70s:ADP IEA Dictyostelium discoideum DDB_G0273249 R-DDI-5618107 https://reactome.org/PathwayBrowser/#/R-DDI-5618107 ATP binding to HSP90 triggers conformation change IEA Dictyostelium discoideum DDB_G0273249 R-DDI-6798748 https://reactome.org/PathwayBrowser/#/R-DDI-6798748 Exocytosis of secretory granule lumen proteins IEA Dictyostelium discoideum DDB_G0273249 R-DDI-6800434 https://reactome.org/PathwayBrowser/#/R-DDI-6800434 Exocytosis of ficolin-rich granule lumen proteins IEA Dictyostelium discoideum DDB_G0273249 R-DDI-9857076 https://reactome.org/PathwayBrowser/#/R-DDI-9857076 Oxidized DNAJA1 binds HSPA1A,B (HSP70) displacing HSF1 IEA Dictyostelium discoideum DDB_G0273251 R-DDI-1363328 https://reactome.org/PathwayBrowser/#/R-DDI-1363328 Phosphorylated p130 (RBL2) binds SCF(Skp2):Cks1 complex IEA Dictyostelium discoideum DDB_G0273251 R-DDI-1363331 https://reactome.org/PathwayBrowser/#/R-DDI-1363331 Ubiquitination of p130 (RBL2) by SCF (Skp2) IEA Dictyostelium discoideum DDB_G0273251 R-DDI-5691108 https://reactome.org/PathwayBrowser/#/R-DDI-5691108 SKP1:FBXL5:CUL1:NEDD8 ubiquitinylates IREB2 IEA Dictyostelium discoideum DDB_G0273251 R-DDI-68946 https://reactome.org/PathwayBrowser/#/R-DDI-68946 Phosphorylated Orc1 is ubiquitinated while still associated with chromatin IEA Dictyostelium discoideum DDB_G0273251 R-DDI-8853496 https://reactome.org/PathwayBrowser/#/R-DDI-8853496 SCF:FBXL7 binds AURKA IEA Dictyostelium discoideum DDB_G0273251 R-DDI-8854041 https://reactome.org/PathwayBrowser/#/R-DDI-8854041 SCF-FBXL7 ubiquitinates AURKA IEA Dictyostelium discoideum DDB_G0273251 R-DDI-8854044 https://reactome.org/PathwayBrowser/#/R-DDI-8854044 Proteasome degrades AURKA ubiquitinated by SCF-FBXL7 IEA Dictyostelium discoideum DDB_G0273251 R-DDI-8952618 https://reactome.org/PathwayBrowser/#/R-DDI-8952618 AcM-UBE2M transfers NEDD8 to CRL1 E3 ubiquitin ligase complex IEA Dictyostelium discoideum DDB_G0273251 R-DDI-8952620 https://reactome.org/PathwayBrowser/#/R-DDI-8952620 NEDD8:AcM-UBE2M binds CRL1 E3 ubiquitin ligase complex IEA Dictyostelium discoideum DDB_G0273251 R-DDI-8955241 https://reactome.org/PathwayBrowser/#/R-DDI-8955241 CAND1 binds cytosolic CRL E3 ubiquitin ligases IEA Dictyostelium discoideum DDB_G0273251 R-DDI-8955289 https://reactome.org/PathwayBrowser/#/R-DDI-8955289 COMMDs displace CAND1 from cytosolic CRL E3 ubiquitin ligase complexes IEA Dictyostelium discoideum DDB_G0273251 R-DDI-8956040 https://reactome.org/PathwayBrowser/#/R-DDI-8956040 COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes IEA Dictyostelium discoideum DDB_G0273251 R-DDI-8956200 https://reactome.org/PathwayBrowser/#/R-DDI-8956200 MyrG-DCUN1D3 binds CRL1 E3 ubiquitin ligase complex IEA Dictyostelium discoideum DDB_G0273251 R-DDI-983140 https://reactome.org/PathwayBrowser/#/R-DDI-983140 Transfer of Ub from E2 to substrate and release of E2 IEA Dictyostelium discoideum DDB_G0273251 R-DDI-983147 https://reactome.org/PathwayBrowser/#/R-DDI-983147 Release of E3 from polyubiquitinated substrate IEA Dictyostelium discoideum DDB_G0273251 R-DDI-983156 https://reactome.org/PathwayBrowser/#/R-DDI-983156 Polyubiquitination of substrate IEA Dictyostelium discoideum DDB_G0273251 R-DDI-983157 https://reactome.org/PathwayBrowser/#/R-DDI-983157 Interaction of E3 with substrate and E2-Ub complex IEA Dictyostelium discoideum DDB_G0273253 R-DDI-4827383 https://reactome.org/PathwayBrowser/#/R-DDI-4827383 WHSC1 (KMT3G), NSD1 (KMT3B), SMYD2 (KMT3C) methylate lysine-37 of histone H3 (H3K36) IEA Dictyostelium discoideum DDB_G0273253 R-DDI-5638157 https://reactome.org/PathwayBrowser/#/R-DDI-5638157 WHSC1 (KMT3G), NSD1 (KMT3B), SMYD2 (KMT3C), ASH1L methylate methyl-lysine-37 of histone H3 (H3K36) IEA Dictyostelium discoideum DDB_G0273259 R-DDI-9793472 https://reactome.org/PathwayBrowser/#/R-DDI-9793472 RIPK3 binds p-S9-PRKN IEA Dictyostelium discoideum DDB_G0273259 R-DDI-9793485 https://reactome.org/PathwayBrowser/#/R-DDI-9793485 PRKN polyubiquitinates RIPK3 IEA Dictyostelium discoideum DDB_G0273291 R-DDI-389821 https://reactome.org/PathwayBrowser/#/R-DDI-389821 glycine + O2 => glyoxylate + H2O2 + NH4+ IEA Dictyostelium discoideum DDB_G0273291 R-DDI-6810076 https://reactome.org/PathwayBrowser/#/R-DDI-6810076 DDO oxidizes D-Asp to OA IEA Dictyostelium discoideum DDB_G0273291 R-DDI-9033235 https://reactome.org/PathwayBrowser/#/R-DDI-9033235 Cargo of PEX5S,L translocates from the cytosol to the peroxisomal matrix IEA Dictyostelium discoideum DDB_G0273291 R-DDI-9033236 https://reactome.org/PathwayBrowser/#/R-DDI-9033236 PEX5S,L:Cargo binds PEX13:PEX14:PEX2:PEX10:PEX12 (Docking and Translocation Module) IEA Dictyostelium discoideum DDB_G0273293 R-DDI-109700 https://reactome.org/PathwayBrowser/#/R-DDI-109700 AKT2 binds PIP3 IEA Dictyostelium discoideum DDB_G0273293 R-DDI-198640 https://reactome.org/PathwayBrowser/#/R-DDI-198640 TORC2 (mTOR) phosphorylates AKT at S473 IEA Dictyostelium discoideum DDB_G0273293 R-DDI-199443 https://reactome.org/PathwayBrowser/#/R-DDI-199443 THEM4 (CTMP) and/or TRIB3 inhibit AKT phosphorylation IEA Dictyostelium discoideum DDB_G0273293 R-DDI-5690066 https://reactome.org/PathwayBrowser/#/R-DDI-5690066 ACOT2,9,THEM4,5 hydrolyse MCFA-CoA, LCFA-CoA IEA Dictyostelium discoideum DDB_G0273381 R-DDI-983140 https://reactome.org/PathwayBrowser/#/R-DDI-983140 Transfer of Ub from E2 to substrate and release of E2 IEA Dictyostelium discoideum DDB_G0273381 R-DDI-983147 https://reactome.org/PathwayBrowser/#/R-DDI-983147 Release of E3 from polyubiquitinated substrate IEA Dictyostelium discoideum DDB_G0273381 R-DDI-983156 https://reactome.org/PathwayBrowser/#/R-DDI-983156 Polyubiquitination of substrate IEA Dictyostelium discoideum DDB_G0273381 R-DDI-983157 https://reactome.org/PathwayBrowser/#/R-DDI-983157 Interaction of E3 with substrate and E2-Ub complex IEA Dictyostelium discoideum DDB_G0273383 R-DDI-9770236 https://reactome.org/PathwayBrowser/#/R-DDI-9770236 Formation of the Spliceosomal P complex and exon ligation IEA Dictyostelium discoideum DDB_G0273393 R-DDI-4827383 https://reactome.org/PathwayBrowser/#/R-DDI-4827383 WHSC1 (KMT3G), NSD1 (KMT3B), SMYD2 (KMT3C) methylate lysine-37 of histone H3 (H3K36) IEA Dictyostelium discoideum DDB_G0273393 R-DDI-5638157 https://reactome.org/PathwayBrowser/#/R-DDI-5638157 WHSC1 (KMT3G), NSD1 (KMT3B), SMYD2 (KMT3C), ASH1L methylate methyl-lysine-37 of histone H3 (H3K36) IEA Dictyostelium discoideum DDB_G0273399 R-DDI-983140 https://reactome.org/PathwayBrowser/#/R-DDI-983140 Transfer of Ub from E2 to substrate and release of E2 IEA Dictyostelium discoideum DDB_G0273399 R-DDI-983147 https://reactome.org/PathwayBrowser/#/R-DDI-983147 Release of E3 from polyubiquitinated substrate IEA Dictyostelium discoideum DDB_G0273399 R-DDI-983156 https://reactome.org/PathwayBrowser/#/R-DDI-983156 Polyubiquitination of substrate IEA Dictyostelium discoideum DDB_G0273399 R-DDI-983157 https://reactome.org/PathwayBrowser/#/R-DDI-983157 Interaction of E3 with substrate and E2-Ub complex IEA Dictyostelium discoideum DDB_G0273419 R-DDI-6798743 https://reactome.org/PathwayBrowser/#/R-DDI-6798743 Exocytosis of secretory granule membrane proteins IEA Dictyostelium discoideum DDB_G0273419 R-DDI-983158 https://reactome.org/PathwayBrowser/#/R-DDI-983158 Trimming of peptides in ER IEA Dictyostelium discoideum DDB_G0273419 R-DDI-983162 https://reactome.org/PathwayBrowser/#/R-DDI-983162 Trimming of N-ter extended precursor fragments by cytosolic aminopeptidases IEA Dictyostelium discoideum DDB_G0273425 R-DDI-76056 https://reactome.org/PathwayBrowser/#/R-DDI-76056 Recruitment of RNA polymerase III to TFIIIB:TFIIIC:TFIIIA:Type 1 Promoter Complex IEA Dictyostelium discoideum DDB_G0273425 R-DDI-83805 https://reactome.org/PathwayBrowser/#/R-DDI-83805 Recruitment of RNA Polymerase III to the TFIIIB:TFIIIC: Type 2 Promoter Complex IEA Dictyostelium discoideum DDB_G0273429 R-DDI-71163 https://reactome.org/PathwayBrowser/#/R-DDI-71163 HPD dioxygenates HPP IEA Dictyostelium discoideum DDB_G0273429 R-DDI-9856718 https://reactome.org/PathwayBrowser/#/R-DDI-9856718 HPDL dioxygenates HPPA IEA Dictyostelium discoideum DDB_G0273439 R-DDI-392749 https://reactome.org/PathwayBrowser/#/R-DDI-392749 Transport of L1 into endosomes IEA Dictyostelium discoideum DDB_G0273439 R-DDI-445079 https://reactome.org/PathwayBrowser/#/R-DDI-445079 Phosphorylation of L1 by ERK IEA Dictyostelium discoideum DDB_G0273439 R-DDI-6784729 https://reactome.org/PathwayBrowser/#/R-DDI-6784729 PCSK9:LDLR:Clathrin-coated vesicle transport from plasma membrane to endolysosome IEA Dictyostelium discoideum DDB_G0273439 R-DDI-6784738 https://reactome.org/PathwayBrowser/#/R-DDI-6784738 Degradation of PCSK9:LDLR:Clathrin-coated vesicle IEA Dictyostelium discoideum DDB_G0273439 R-DDI-6798743 https://reactome.org/PathwayBrowser/#/R-DDI-6798743 Exocytosis of secretory granule membrane proteins IEA Dictyostelium discoideum DDB_G0273439 R-DDI-6800426 https://reactome.org/PathwayBrowser/#/R-DDI-6800426 Exocytosis of ficolin-rich granule membrane proteins IEA Dictyostelium discoideum DDB_G0273439 R-DDI-8855130 https://reactome.org/PathwayBrowser/#/R-DDI-8855130 VLDLR:PCSK9:Clathrin-coated vesicle translocates from the plasma membrane to lysosomal membrane IEA Dictyostelium discoideum DDB_G0273439 R-DDI-8856813 https://reactome.org/PathwayBrowser/#/R-DDI-8856813 AAK1 phosphorylates AP-2 mu subunit at T156 IEA Dictyostelium discoideum DDB_G0273439 R-DDI-8866277 https://reactome.org/PathwayBrowser/#/R-DDI-8866277 AP-2 directly binds some endocytic cargo IEA Dictyostelium discoideum DDB_G0273439 R-DDI-8868072 https://reactome.org/PathwayBrowser/#/R-DDI-8868072 Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2 IEA Dictyostelium discoideum DDB_G0273439 R-DDI-8871196 https://reactome.org/PathwayBrowser/#/R-DDI-8871196 Initial binding of AP-2 and clathrin to PI(4,5)P2 IEA Dictyostelium discoideum DDB_G0273439 R-DDI-9681616 https://reactome.org/PathwayBrowser/#/R-DDI-9681616 AP2 binds chlorpromazine IEA Dictyostelium discoideum DDB_G0273443 R-DDI-5681987 https://reactome.org/PathwayBrowser/#/R-DDI-5681987 LC3 is cleaved by ATG4 IEA Dictyostelium discoideum DDB_G0273443 R-DDI-5682377 https://reactome.org/PathwayBrowser/#/R-DDI-5682377 LC3 de-lipidation by ATG4 IEA Dictyostelium discoideum DDB_G0273445 R-DDI-5672948 https://reactome.org/PathwayBrowser/#/R-DDI-5672948 MARK3 phosphorylates KSR1 IEA Dictyostelium discoideum DDB_G0273445 R-DDI-5674019 https://reactome.org/PathwayBrowser/#/R-DDI-5674019 BRAP binds KSR1:MARK3 IEA Dictyostelium discoideum DDB_G0273447 R-DDI-6798748 https://reactome.org/PathwayBrowser/#/R-DDI-6798748 Exocytosis of secretory granule lumen proteins IEA Dictyostelium discoideum DDB_G0273447 R-DDI-6800434 https://reactome.org/PathwayBrowser/#/R-DDI-6800434 Exocytosis of ficolin-rich granule lumen proteins IEA Dictyostelium discoideum DDB_G0273451 R-DDI-983140 https://reactome.org/PathwayBrowser/#/R-DDI-983140 Transfer of Ub from E2 to substrate and release of E2 IEA Dictyostelium discoideum DDB_G0273451 R-DDI-983147 https://reactome.org/PathwayBrowser/#/R-DDI-983147 Release of E3 from polyubiquitinated substrate IEA Dictyostelium discoideum DDB_G0273451 R-DDI-983156 https://reactome.org/PathwayBrowser/#/R-DDI-983156 Polyubiquitination of substrate IEA Dictyostelium discoideum DDB_G0273451 R-DDI-983157 https://reactome.org/PathwayBrowser/#/R-DDI-983157 Interaction of E3 with substrate and E2-Ub complex IEA Dictyostelium discoideum DDB_G0273467 R-DDI-5694409 https://reactome.org/PathwayBrowser/#/R-DDI-5694409 Nucleotide exchange on RAB1 IEA Dictyostelium discoideum DDB_G0273467 R-DDI-5694439 https://reactome.org/PathwayBrowser/#/R-DDI-5694439 COPII coat binds TRAPPCII and RAB1:GDP IEA Dictyostelium discoideum DDB_G0273467 R-DDI-5694441 https://reactome.org/PathwayBrowser/#/R-DDI-5694441 CSNK1D phosphorylates SEC23 IEA Dictyostelium discoideum DDB_G0273467 R-DDI-6798751 https://reactome.org/PathwayBrowser/#/R-DDI-6798751 Exocytosis of azurophil granule lumen proteins IEA Dictyostelium discoideum DDB_G0273467 R-DDI-8877475 https://reactome.org/PathwayBrowser/#/R-DDI-8877475 TRAPPC complexes exchange GTP for GDP on RAB1 IEA Dictyostelium discoideum DDB_G0273473 R-DDI-6800426 https://reactome.org/PathwayBrowser/#/R-DDI-6800426 Exocytosis of ficolin-rich granule membrane proteins IEA Dictyostelium discoideum DDB_G0273525 R-DDI-109639 https://reactome.org/PathwayBrowser/#/R-DDI-109639 Formation of the closed pre-initiation complex IEA Dictyostelium discoideum DDB_G0273525 R-DDI-6810233 https://reactome.org/PathwayBrowser/#/R-DDI-6810233 CDK7 phosphorylates serine-5 and serine-7 of heptad repeats in C-terminal domain of RNA polymerase II at snRNA promoter IEA Dictyostelium discoideum DDB_G0273525 R-DDI-6810238 https://reactome.org/PathwayBrowser/#/R-DDI-6810238 RNA polymerase II binds initiation factors at promoter of snRNA gene (U1, U2, U4, U4atac, U5, U11, U12) IEA Dictyostelium discoideum DDB_G0273525 R-DDI-6814555 https://reactome.org/PathwayBrowser/#/R-DDI-6814555 Integrator complex processes the 3' end of snRNA IEA Dictyostelium discoideum DDB_G0273525 R-DDI-6814559 https://reactome.org/PathwayBrowser/#/R-DDI-6814559 Pre-snRNA is elongated and capped with 7-methylguanosine IEA Dictyostelium discoideum DDB_G0273525 R-DDI-73946 https://reactome.org/PathwayBrowser/#/R-DDI-73946 Abortive initiation after formation of the first phosphodiester bond IEA Dictyostelium discoideum DDB_G0273525 R-DDI-75095 https://reactome.org/PathwayBrowser/#/R-DDI-75095 Binding of TFIIE to the growing preinitiation complex IEA Dictyostelium discoideum DDB_G0273525 R-DDI-75850 https://reactome.org/PathwayBrowser/#/R-DDI-75850 Addition of the third nucleotide on the nascent transcript IEA Dictyostelium discoideum DDB_G0273525 R-DDI-75856 https://reactome.org/PathwayBrowser/#/R-DDI-75856 Abortive Initiation Before Second Transition IEA Dictyostelium discoideum DDB_G0273525 R-DDI-75861 https://reactome.org/PathwayBrowser/#/R-DDI-75861 NTP Binds Active Site of RNA Polymerase II IEA Dictyostelium discoideum DDB_G0273525 R-DDI-75862 https://reactome.org/PathwayBrowser/#/R-DDI-75862 Fall Back to Closed Pre-initiation Complex IEA Dictyostelium discoideum DDB_G0273525 R-DDI-75864 https://reactome.org/PathwayBrowser/#/R-DDI-75864 Newly Formed Phosphodiester Bond Stabilized and PPi Released IEA Dictyostelium discoideum DDB_G0273525 R-DDI-75866 https://reactome.org/PathwayBrowser/#/R-DDI-75866 Nucleophillic Attack by 3'-hydroxyl Oxygen of nascent transcript on the Alpha Phosphate of NTP IEA Dictyostelium discoideum DDB_G0273525 R-DDI-75869 https://reactome.org/PathwayBrowser/#/R-DDI-75869 Addition of the fourth nucleotide on the Nascent Transcript: Second Transition IEA Dictyostelium discoideum DDB_G0273525 R-DDI-75873 https://reactome.org/PathwayBrowser/#/R-DDI-75873 Addition of Nucleotides 5 through 9 on the growing Transcript IEA Dictyostelium discoideum DDB_G0273525 R-DDI-75891 https://reactome.org/PathwayBrowser/#/R-DDI-75891 Abortive Initiation After Second Transition IEA Dictyostelium discoideum DDB_G0273525 R-DDI-75949 https://reactome.org/PathwayBrowser/#/R-DDI-75949 RNA Polymerase II Promoter Opening: First Transition IEA Dictyostelium discoideum DDB_G0273525 R-DDI-9613494 https://reactome.org/PathwayBrowser/#/R-DDI-9613494 Unwinding of DNA for the Nascent Transcript: Second Transition IEA Dictyostelium discoideum DDB_G0273525 R-DDI-9613497 https://reactome.org/PathwayBrowser/#/R-DDI-9613497 Unwinding DNA for the nascent transcript IEA Dictyostelium discoideum DDB_G0273573 R-DDI-983140 https://reactome.org/PathwayBrowser/#/R-DDI-983140 Transfer of Ub from E2 to substrate and release of E2 IEA Dictyostelium discoideum DDB_G0273573 R-DDI-983147 https://reactome.org/PathwayBrowser/#/R-DDI-983147 Release of E3 from polyubiquitinated substrate IEA Dictyostelium discoideum DDB_G0273573 R-DDI-983156 https://reactome.org/PathwayBrowser/#/R-DDI-983156 Polyubiquitination of substrate IEA Dictyostelium discoideum DDB_G0273573 R-DDI-983157 https://reactome.org/PathwayBrowser/#/R-DDI-983157 Interaction of E3 with substrate and E2-Ub complex IEA Dictyostelium discoideum DDB_G0273631 R-DDI-9770236 https://reactome.org/PathwayBrowser/#/R-DDI-9770236 Formation of the Spliceosomal P complex and exon ligation IEA Dictyostelium discoideum DDB_G0273633 R-DDI-9013144 https://reactome.org/PathwayBrowser/#/R-DDI-9013144 RAC1 GAPs stimulate RAC1 GTPase activity IEA Dictyostelium discoideum DDB_G0273633 R-DDI-9013145 https://reactome.org/PathwayBrowser/#/R-DDI-9013145 RAC1 binds effectors at the plasma membrane IEA Dictyostelium discoideum DDB_G0273633 R-DDI-9013161 https://reactome.org/PathwayBrowser/#/R-DDI-9013161 CDC42 GAPs stimulate CDC42 GTPase activity IEA Dictyostelium discoideum DDB_G0273633 R-DDI-9014294 https://reactome.org/PathwayBrowser/#/R-DDI-9014294 RAC2 binds effectors at the plasma membrane IEA Dictyostelium discoideum DDB_G0273633 R-DDI-9014295 https://reactome.org/PathwayBrowser/#/R-DDI-9014295 RAC2 GAPs stimulate RAC2 GTPase activity IEA Dictyostelium discoideum DDB_G0273633 R-DDI-9014449 https://reactome.org/PathwayBrowser/#/R-DDI-9014449 RHOG binds effectors at the plasma membrane IEA Dictyostelium discoideum DDB_G0273633 R-DDI-9017488 https://reactome.org/PathwayBrowser/#/R-DDI-9017488 RHOJ GAPs stimulate RHOJ GTPase activity IEA Dictyostelium discoideum DDB_G0273633 R-DDI-9018745 https://reactome.org/PathwayBrowser/#/R-DDI-9018745 RHOQ GAPs stimulate RHOQ GTPase activity IEA Dictyostelium discoideum DDB_G0273633 R-DDI-9018746 https://reactome.org/PathwayBrowser/#/R-DDI-9018746 RHOQ binds effectors at the plasma membrane IEA Dictyostelium discoideum DDB_G0273633 R-DDI-9018766 https://reactome.org/PathwayBrowser/#/R-DDI-9018766 RHOU binds effectors at the plasma membrane IEA Dictyostelium discoideum DDB_G0273633 R-DDI-9018794 https://reactome.org/PathwayBrowser/#/R-DDI-9018794 RHOV binds effectors at the plasma membrane IEA Dictyostelium discoideum DDB_G0273633 R-DDI-9018806 https://reactome.org/PathwayBrowser/#/R-DDI-9018806 RAC3 GAPs stimulate RAC3 GTPase activity IEA Dictyostelium discoideum DDB_G0273633 R-DDI-9018808 https://reactome.org/PathwayBrowser/#/R-DDI-9018808 RAC3 binds effectors at the plasma membrane IEA Dictyostelium discoideum DDB_G0273855 R-DDI-5419165 https://reactome.org/PathwayBrowser/#/R-DDI-5419165 RDH11,14,DHRS3,DRHS4 reduce atRAL to atROL IEA Dictyostelium discoideum DDB_G0274105 R-DDI-3322005 https://reactome.org/PathwayBrowser/#/R-DDI-3322005 GBE1 catalyzes branch formation in polyGlc-GYG1 complexed with GYS1-a IEA Dictyostelium discoideum DDB_G0274105 R-DDI-3322016 https://reactome.org/PathwayBrowser/#/R-DDI-3322016 GBE1 catalyzes branch formation in polyGlc-GYG2 complexed with GYS2-a IEA Dictyostelium discoideum DDB_G0274105 R-DDI-3322057 https://reactome.org/PathwayBrowser/#/R-DDI-3322057 GBE1 catalyzes branch formation in polyGlc-GYG1 complexed with GYS1-b IEA Dictyostelium discoideum DDB_G0274113 R-DDI-156826 https://reactome.org/PathwayBrowser/#/R-DDI-156826 Dissociation of L13a from the 60s ribosomal subunit IEA Dictyostelium discoideum DDB_G0274113 R-DDI-1799332 https://reactome.org/PathwayBrowser/#/R-DDI-1799332 Nascent polypeptide:mRNA:ribosome complex binds signal recognition particle (SRP) IEA Dictyostelium discoideum DDB_G0274113 R-DDI-72671 https://reactome.org/PathwayBrowser/#/R-DDI-72671 eIF5B:GTP is hydrolyzed and released IEA Dictyostelium discoideum DDB_G0274113 R-DDI-72672 https://reactome.org/PathwayBrowser/#/R-DDI-72672 The 60S subunit joins the translation initiation complex IEA Dictyostelium discoideum DDB_G0274113 R-DDI-72673 https://reactome.org/PathwayBrowser/#/R-DDI-72673 Release of 40S and 60S subunits from the 80S ribosome IEA Dictyostelium discoideum DDB_G0274113 R-DDI-927789 https://reactome.org/PathwayBrowser/#/R-DDI-927789 Formation of UPF1:eRF3 complex on mRNA with a premature termination codon and no Exon Junction Complex IEA Dictyostelium discoideum DDB_G0274113 R-DDI-927832 https://reactome.org/PathwayBrowser/#/R-DDI-927832 UPF1 binds an mRNP with a termination codon preceding an Exon Junction Complex IEA Dictyostelium discoideum DDB_G0274113 R-DDI-927889 https://reactome.org/PathwayBrowser/#/R-DDI-927889 SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex) IEA Dictyostelium discoideum DDB_G0274113 R-DDI-9630993 https://reactome.org/PathwayBrowser/#/R-DDI-9630993 RIOX1:Fe2+ hydroxylates a histidine residue of RPL8 IEA Dictyostelium discoideum DDB_G0274115 R-DDI-265783 https://reactome.org/PathwayBrowser/#/R-DDI-265783 ABCG5:ABCG8 transports sterols from cytosol to extracellular region IEA Dictyostelium discoideum DDB_G0274115 R-DDI-917979 https://reactome.org/PathwayBrowser/#/R-DDI-917979 ABCG2 tetramer transports heme from cytosol to extracellular region IEA Dictyostelium discoideum DDB_G0274115 R-DDI-9661417 https://reactome.org/PathwayBrowser/#/R-DDI-9661417 ABCG2 tetramer transports BMG,BDG from cytosol to extracellular region IEA Dictyostelium discoideum DDB_G0274115 R-DDI-9753278 https://reactome.org/PathwayBrowser/#/R-DDI-9753278 ABCC2,ABCG2 transport APAP-GlcA, APAP-SO3 IEA Dictyostelium discoideum DDB_G0274115 R-DDI-9794120 https://reactome.org/PathwayBrowser/#/R-DDI-9794120 ABCG2 transports Cipro from intestinal cell to extracellular space IEA Dictyostelium discoideum DDB_G0274115 R-DDI-9794572 https://reactome.org/PathwayBrowser/#/R-DDI-9794572 ABCG2 transports Cipro from hepatic cell to extracellular space IEA Dictyostelium discoideum DDB_G0274115 R-DDI-9843721 https://reactome.org/PathwayBrowser/#/R-DDI-9843721 ABCC1,ABCG2 transport C18-S1P to extracellular region IEA Dictyostelium discoideum DDB_G0274117 R-DDI-265783 https://reactome.org/PathwayBrowser/#/R-DDI-265783 ABCG5:ABCG8 transports sterols from cytosol to extracellular region IEA Dictyostelium discoideum DDB_G0274117 R-DDI-917979 https://reactome.org/PathwayBrowser/#/R-DDI-917979 ABCG2 tetramer transports heme from cytosol to extracellular region IEA Dictyostelium discoideum DDB_G0274117 R-DDI-9661417 https://reactome.org/PathwayBrowser/#/R-DDI-9661417 ABCG2 tetramer transports BMG,BDG from cytosol to extracellular region IEA Dictyostelium discoideum DDB_G0274117 R-DDI-9753278 https://reactome.org/PathwayBrowser/#/R-DDI-9753278 ABCC2,ABCG2 transport APAP-GlcA, APAP-SO3 IEA Dictyostelium discoideum DDB_G0274117 R-DDI-9794120 https://reactome.org/PathwayBrowser/#/R-DDI-9794120 ABCG2 transports Cipro from intestinal cell to extracellular space IEA Dictyostelium discoideum DDB_G0274117 R-DDI-9794572 https://reactome.org/PathwayBrowser/#/R-DDI-9794572 ABCG2 transports Cipro from hepatic cell to extracellular space IEA Dictyostelium discoideum DDB_G0274117 R-DDI-9843721 https://reactome.org/PathwayBrowser/#/R-DDI-9843721 ABCC1,ABCG2 transport C18-S1P to extracellular region IEA Dictyostelium discoideum DDB_G0274119 R-DDI-1369028 https://reactome.org/PathwayBrowser/#/R-DDI-1369028 ABCAs mediate lipid efflux IEA Dictyostelium discoideum DDB_G0274119 R-DDI-1369052 https://reactome.org/PathwayBrowser/#/R-DDI-1369052 ABCAs mediate lipid influx IEA Dictyostelium discoideum DDB_G0274119 R-DDI-1467457 https://reactome.org/PathwayBrowser/#/R-DDI-1467457 ABCA8,B1,B5 transport xenobiotics from cytosol to extracellular region IEA Dictyostelium discoideum DDB_G0274119 R-DDI-1467466 https://reactome.org/PathwayBrowser/#/R-DDI-1467466 ABCA4 mediates atRAL transport IEA Dictyostelium discoideum DDB_G0274119 R-DDI-5682103 https://reactome.org/PathwayBrowser/#/R-DDI-5682103 4xPALM-C-ABCA1 tetramer translocates from ER membrane to plasma membrane IEA Dictyostelium discoideum DDB_G0274119 R-DDI-5682285 https://reactome.org/PathwayBrowser/#/R-DDI-5682285 ABCA12 transports lipids from cytosol to extracellular region IEA Dictyostelium discoideum DDB_G0274119 R-DDI-5683714 https://reactome.org/PathwayBrowser/#/R-DDI-5683714 ABCA3 transports PC, PG from ER membrane to lamellar body IEA Dictyostelium discoideum DDB_G0274119 R-DDI-6798739 https://reactome.org/PathwayBrowser/#/R-DDI-6798739 Exocytosis of azurophil granule membrane proteins IEA Dictyostelium discoideum DDB_G0274119 R-DDI-6798743 https://reactome.org/PathwayBrowser/#/R-DDI-6798743 Exocytosis of secretory granule membrane proteins IEA Dictyostelium discoideum DDB_G0274121 R-DDI-1369028 https://reactome.org/PathwayBrowser/#/R-DDI-1369028 ABCAs mediate lipid efflux IEA Dictyostelium discoideum DDB_G0274121 R-DDI-1369052 https://reactome.org/PathwayBrowser/#/R-DDI-1369052 ABCAs mediate lipid influx IEA Dictyostelium discoideum DDB_G0274121 R-DDI-1467457 https://reactome.org/PathwayBrowser/#/R-DDI-1467457 ABCA8,B1,B5 transport xenobiotics from cytosol to extracellular region IEA Dictyostelium discoideum DDB_G0274121 R-DDI-1467466 https://reactome.org/PathwayBrowser/#/R-DDI-1467466 ABCA4 mediates atRAL transport IEA Dictyostelium discoideum DDB_G0274121 R-DDI-5682103 https://reactome.org/PathwayBrowser/#/R-DDI-5682103 4xPALM-C-ABCA1 tetramer translocates from ER membrane to plasma membrane IEA Dictyostelium discoideum DDB_G0274121 R-DDI-5682285 https://reactome.org/PathwayBrowser/#/R-DDI-5682285 ABCA12 transports lipids from cytosol to extracellular region IEA Dictyostelium discoideum DDB_G0274121 R-DDI-5683714 https://reactome.org/PathwayBrowser/#/R-DDI-5683714 ABCA3 transports PC, PG from ER membrane to lamellar body IEA Dictyostelium discoideum DDB_G0274121 R-DDI-6798739 https://reactome.org/PathwayBrowser/#/R-DDI-6798739 Exocytosis of azurophil granule membrane proteins IEA Dictyostelium discoideum DDB_G0274121 R-DDI-6798743 https://reactome.org/PathwayBrowser/#/R-DDI-6798743 Exocytosis of secretory granule membrane proteins IEA Dictyostelium discoideum DDB_G0274121 R-DDI-8848053 https://reactome.org/PathwayBrowser/#/R-DDI-8848053 ABCA5 transports CHOL from lysosomal lumen to cytosol IEA Dictyostelium discoideum DDB_G0274123 R-DDI-73591 https://reactome.org/PathwayBrowser/#/R-DDI-73591 beta-ureidopropionate + H2O => beta-alanine + NH4+ + CO2 IEA Dictyostelium discoideum DDB_G0274123 R-DDI-73620 https://reactome.org/PathwayBrowser/#/R-DDI-73620 beta-ureidoisobutyrate + H2O => 3-aminoisobutyrate + NH4+ + CO2 IEA Dictyostelium discoideum DDB_G0274141 R-DDI-1222516 https://reactome.org/PathwayBrowser/#/R-DDI-1222516 Intraphagosomal pH is lowered to 5 by V-ATPase IEA Dictyostelium discoideum DDB_G0274141 R-DDI-74723 https://reactome.org/PathwayBrowser/#/R-DDI-74723 Endosome acidification IEA Dictyostelium discoideum DDB_G0274141 R-DDI-917841 https://reactome.org/PathwayBrowser/#/R-DDI-917841 Acidification of Tf:TfR1 containing endosome IEA Dictyostelium discoideum DDB_G0274141 R-DDI-9639286 https://reactome.org/PathwayBrowser/#/R-DDI-9639286 RRAGC,D exchanges GTP for GDP IEA Dictyostelium discoideum DDB_G0274141 R-DDI-9640167 https://reactome.org/PathwayBrowser/#/R-DDI-9640167 RRAGA,B exchanges GDP for GTP IEA Dictyostelium discoideum DDB_G0274141 R-DDI-9640195 https://reactome.org/PathwayBrowser/#/R-DDI-9640195 RRAGA,B hydrolyzes GTP IEA Dictyostelium discoideum DDB_G0274141 R-DDI-9645598 https://reactome.org/PathwayBrowser/#/R-DDI-9645598 RRAGC,D hydrolyzes GTP IEA Dictyostelium discoideum DDB_G0274141 R-DDI-9645608 https://reactome.org/PathwayBrowser/#/R-DDI-9645608 v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP binds mTORC1 IEA Dictyostelium discoideum DDB_G0274141 R-DDI-9646468 https://reactome.org/PathwayBrowser/#/R-DDI-9646468 mTORC1 binds RHEB:GTP IEA Dictyostelium discoideum DDB_G0274167 R-DDI-5691131 https://reactome.org/PathwayBrowser/#/R-DDI-5691131 CANDI binds CUL1 IEA Dictyostelium discoideum DDB_G0274167 R-DDI-6798748 https://reactome.org/PathwayBrowser/#/R-DDI-6798748 Exocytosis of secretory granule lumen proteins IEA Dictyostelium discoideum DDB_G0274167 R-DDI-6800434 https://reactome.org/PathwayBrowser/#/R-DDI-6800434 Exocytosis of ficolin-rich granule lumen proteins IEA Dictyostelium discoideum DDB_G0274167 R-DDI-8955241 https://reactome.org/PathwayBrowser/#/R-DDI-8955241 CAND1 binds cytosolic CRL E3 ubiquitin ligases IEA Dictyostelium discoideum DDB_G0274167 R-DDI-8955245 https://reactome.org/PathwayBrowser/#/R-DDI-8955245 CAND1 binds CRL4 E3 ubiquitin ligase in the nucleus IEA Dictyostelium discoideum DDB_G0274167 R-DDI-8955285 https://reactome.org/PathwayBrowser/#/R-DDI-8955285 COMMDs displace CAND1 from CRL4 E3 ubiquitin ligase complex IEA Dictyostelium discoideum DDB_G0274167 R-DDI-8955289 https://reactome.org/PathwayBrowser/#/R-DDI-8955289 COMMDs displace CAND1 from cytosolic CRL E3 ubiquitin ligase complexes IEA Dictyostelium discoideum DDB_G0274183 R-DDI-168400 https://reactome.org/PathwayBrowser/#/R-DDI-168400 iE-DAP elicits a NOD1 response IEA Dictyostelium discoideum DDB_G0274183 R-DDI-168412 https://reactome.org/PathwayBrowser/#/R-DDI-168412 MDP elicits a NOD2 response IEA Dictyostelium discoideum DDB_G0274183 R-DDI-622310 https://reactome.org/PathwayBrowser/#/R-DDI-622310 Activated NOD1 oligomerizes IEA Dictyostelium discoideum DDB_G0274183 R-DDI-708349 https://reactome.org/PathwayBrowser/#/R-DDI-708349 Activated NOD2 oligomerizes IEA Dictyostelium discoideum DDB_G0274183 R-DDI-9676160 https://reactome.org/PathwayBrowser/#/R-DDI-9676160 AAMP binds NOD2 IEA Dictyostelium discoideum DDB_G0274183 R-DDI-9750942 https://reactome.org/PathwayBrowser/#/R-DDI-9750942 USP14 deubiquitinates NLRC5 IEA Dictyostelium discoideum DDB_G0274205 R-DDI-3095889 https://reactome.org/PathwayBrowser/#/R-DDI-3095889 MMACHC dealkylates RCbl IEA Dictyostelium discoideum DDB_G0274205 R-DDI-3149519 https://reactome.org/PathwayBrowser/#/R-DDI-3149519 MMACHC decyanates CNCbl IEA Dictyostelium discoideum DDB_G0274205 R-DDI-9759549 https://reactome.org/PathwayBrowser/#/R-DDI-9759549 Cob(I)alamin bound to MMACHC is oxidized to cob(II)alamin IEA Dictyostelium discoideum DDB_G0274207 R-DDI-6781814 https://reactome.org/PathwayBrowser/#/R-DDI-6781814 USP19 deubiquitinates RNF123 IEA Dictyostelium discoideum DDB_G0274211 R-DDI-5658424 https://reactome.org/PathwayBrowser/#/R-DDI-5658424 KBTBD7:CUL3:RBX1 ubiquitinates NF1 IEA Dictyostelium discoideum DDB_G0274211 R-DDI-5658430 https://reactome.org/PathwayBrowser/#/R-DDI-5658430 NF1 is degraded by the proteasome IEA Dictyostelium discoideum DDB_G0274211 R-DDI-5658438 https://reactome.org/PathwayBrowser/#/R-DDI-5658438 SPRED dimer binds NF1 IEA Dictyostelium discoideum DDB_G0274229 R-DDI-9770236 https://reactome.org/PathwayBrowser/#/R-DDI-9770236 Formation of the Spliceosomal P complex and exon ligation IEA Dictyostelium discoideum DDB_G0274241 R-DDI-9018778 https://reactome.org/PathwayBrowser/#/R-DDI-9018778 RHOBTB1 binds interacting proteins at the endosome membrane IEA Dictyostelium discoideum DDB_G0274247 R-DDI-9018758 https://reactome.org/PathwayBrowser/#/R-DDI-9018758 RHOH binds effectors at the plasma membrane IEA Dictyostelium discoideum DDB_G0274261 R-DDI-8866277 https://reactome.org/PathwayBrowser/#/R-DDI-8866277 AP-2 directly binds some endocytic cargo IEA Dictyostelium discoideum DDB_G0274261 R-DDI-8868072 https://reactome.org/PathwayBrowser/#/R-DDI-8868072 Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2 IEA Dictyostelium discoideum DDB_G0274263 R-DDI-176054 https://reactome.org/PathwayBrowser/#/R-DDI-176054 GST dimers conjugate GSH with cytosolic substrates IEA Dictyostelium discoideum DDB_G0274263 R-DDI-3343700 https://reactome.org/PathwayBrowser/#/R-DDI-3343700 PRDX6:GSTP1 catalyzes 2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O IEA Dictyostelium discoideum DDB_G0274263 R-DDI-6798748 https://reactome.org/PathwayBrowser/#/R-DDI-6798748 Exocytosis of secretory granule lumen proteins IEA Dictyostelium discoideum DDB_G0274263 R-DDI-6800434 https://reactome.org/PathwayBrowser/#/R-DDI-6800434 Exocytosis of ficolin-rich granule lumen proteins IEA Dictyostelium discoideum DDB_G0274263 R-DDI-9663492 https://reactome.org/PathwayBrowser/#/R-DDI-9663492 BIL dissociates from GSTA1, FABP1 IEA Dictyostelium discoideum DDB_G0274263 R-DDI-9663511 https://reactome.org/PathwayBrowser/#/R-DDI-9663511 BIL binds GSTA1, FABP1 IEA Dictyostelium discoideum DDB_G0274263 R-DDI-9748996 https://reactome.org/PathwayBrowser/#/R-DDI-9748996 GST dimers cleave AZA to 6MP IEA Dictyostelium discoideum DDB_G0274263 R-DDI-9753280 https://reactome.org/PathwayBrowser/#/R-DDI-9753280 GSTs transfer GSH to NAPQI to form APAP-SG IEA Dictyostelium discoideum DDB_G0274269 R-DDI-3662318 https://reactome.org/PathwayBrowser/#/R-DDI-3662318 Type B histone acetlytransferase complex acetylates histone H4 IEA Dictyostelium discoideum DDB_G0274297 R-DDI-5693925 https://reactome.org/PathwayBrowser/#/R-DDI-5693925 FUT3 transfers L-fucose to Gal1,3GlcNAc IEA Dictyostelium discoideum DDB_G0274297 R-DDI-9603984 https://reactome.org/PathwayBrowser/#/R-DDI-9603984 FUT4,5,9,(10,11) transfer Fuc to Type 2 chains to form LeX IEA Dictyostelium discoideum DDB_G0274297 R-DDI-9603986 https://reactome.org/PathwayBrowser/#/R-DDI-9603986 FUT3 transfers Fuc to Type 1 chains to form LeA IEA Dictyostelium discoideum DDB_G0274297 R-DDI-9605609 https://reactome.org/PathwayBrowser/#/R-DDI-9605609 FUT3 transfers Fuc to Type 1 MSGG to form sLeA IEA Dictyostelium discoideum DDB_G0274297 R-DDI-9605644 https://reactome.org/PathwayBrowser/#/R-DDI-9605644 FUT3 transfers Fuc to Type 1 DSGG to form dsLeA IEA Dictyostelium discoideum DDB_G0274297 R-DDI-9605682 https://reactome.org/PathwayBrowser/#/R-DDI-9605682 FUT3,5,6,7 transfers Fuc to Type 2 MSGG to form sLeX IEA Dictyostelium discoideum DDB_G0274301 R-DDI-8849748 https://reactome.org/PathwayBrowser/#/R-DDI-8849748 The COG complex binds RABs at the Golgi membrane IEA Dictyostelium discoideum DDB_G0274301 R-DDI-8870466 https://reactome.org/PathwayBrowser/#/R-DDI-8870466 RGGT:CHM binds RABs IEA Dictyostelium discoideum DDB_G0274301 R-DDI-8870469 https://reactome.org/PathwayBrowser/#/R-DDI-8870469 RGGT geranylgeranylates RAB proteins IEA Dictyostelium discoideum DDB_G0274325 R-DDI-6791222 https://reactome.org/PathwayBrowser/#/R-DDI-6791222 21S pre-rRNA is nucleolytically processed at site E (site2a) to yield 18SE pre-rRNA IEA Dictyostelium discoideum DDB_G0274325 R-DDI-6791227 https://reactome.org/PathwayBrowser/#/R-DDI-6791227 47S pre-rRNA is nucleolytically processed at A' (01,A1), site A0, and site 02 (site 6) to yield 45S pre-rRNA IEA Dictyostelium discoideum DDB_G0274331 R-DDI-1222516 https://reactome.org/PathwayBrowser/#/R-DDI-1222516 Intraphagosomal pH is lowered to 5 by V-ATPase IEA Dictyostelium discoideum DDB_G0274331 R-DDI-6799350 https://reactome.org/PathwayBrowser/#/R-DDI-6799350 Exocytosis of specific granule membrane proteins IEA Dictyostelium discoideum DDB_G0274331 R-DDI-74723 https://reactome.org/PathwayBrowser/#/R-DDI-74723 Endosome acidification IEA Dictyostelium discoideum DDB_G0274331 R-DDI-917841 https://reactome.org/PathwayBrowser/#/R-DDI-917841 Acidification of Tf:TfR1 containing endosome IEA Dictyostelium discoideum DDB_G0274331 R-DDI-9639286 https://reactome.org/PathwayBrowser/#/R-DDI-9639286 RRAGC,D exchanges GTP for GDP IEA Dictyostelium discoideum DDB_G0274331 R-DDI-9640167 https://reactome.org/PathwayBrowser/#/R-DDI-9640167 RRAGA,B exchanges GDP for GTP IEA Dictyostelium discoideum DDB_G0274331 R-DDI-9640195 https://reactome.org/PathwayBrowser/#/R-DDI-9640195 RRAGA,B hydrolyzes GTP IEA Dictyostelium discoideum DDB_G0274331 R-DDI-9645598 https://reactome.org/PathwayBrowser/#/R-DDI-9645598 RRAGC,D hydrolyzes GTP IEA Dictyostelium discoideum DDB_G0274331 R-DDI-9645608 https://reactome.org/PathwayBrowser/#/R-DDI-9645608 v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP binds mTORC1 IEA Dictyostelium discoideum DDB_G0274331 R-DDI-9646468 https://reactome.org/PathwayBrowser/#/R-DDI-9646468 mTORC1 binds RHEB:GTP IEA Dictyostelium discoideum DDB_G0274339 R-DDI-2066788 https://reactome.org/PathwayBrowser/#/R-DDI-2066788 Formation of DHA-CoA catalysed by 3-ketoacyl-CoA thiolase IEA Dictyostelium discoideum DDB_G0274339 R-DDI-390250 https://reactome.org/PathwayBrowser/#/R-DDI-390250 3-ketohexacosanoyl-CoA + CoASH => tetracosanoyl-CoA + acetyl-CoA IEA Dictyostelium discoideum DDB_G0274339 R-DDI-6798749 https://reactome.org/PathwayBrowser/#/R-DDI-6798749 Exocytosis of specific granule lumen proteins IEA Dictyostelium discoideum DDB_G0274339 R-DDI-9033232 https://reactome.org/PathwayBrowser/#/R-DDI-9033232 PEX7 binds cargo proteins containing PTS2 IEA Dictyostelium discoideum DDB_G0274339 R-DDI-9033514 https://reactome.org/PathwayBrowser/#/R-DDI-9033514 Cargo of PEX5L:PEX7 translocates from the cytosol to the peroxisomal matrix IEA Dictyostelium discoideum DDB_G0274357 R-DDI-2586748 https://reactome.org/PathwayBrowser/#/R-DDI-2586748 GUCA binds Ca2+ to form GUCA:Ca2+ IEA Dictyostelium discoideum DDB_G0274357 R-DDI-74885 https://reactome.org/PathwayBrowser/#/R-DDI-74885 GUCYs converts GTP to cGMP IEA Dictyostelium discoideum DDB_G0274359 R-DDI-2586748 https://reactome.org/PathwayBrowser/#/R-DDI-2586748 GUCA binds Ca2+ to form GUCA:Ca2+ IEA Dictyostelium discoideum DDB_G0274359 R-DDI-74885 https://reactome.org/PathwayBrowser/#/R-DDI-74885 GUCYs converts GTP to cGMP IEA Dictyostelium discoideum DDB_G0274375 R-DDI-481007 https://reactome.org/PathwayBrowser/#/R-DDI-481007 Exocytosis of platelet alpha granule contents IEA Dictyostelium discoideum DDB_G0274375 R-DDI-6798745 https://reactome.org/PathwayBrowser/#/R-DDI-6798745 Exocytosis of tertiary granule lumen proteins IEA Dictyostelium discoideum DDB_G0274375 R-DDI-6798748 https://reactome.org/PathwayBrowser/#/R-DDI-6798748 Exocytosis of secretory granule lumen proteins IEA Dictyostelium discoideum DDB_G0274375 R-DDI-6800434 https://reactome.org/PathwayBrowser/#/R-DDI-6800434 Exocytosis of ficolin-rich granule lumen proteins IEA Dictyostelium discoideum DDB_G0274375 R-DDI-70342 https://reactome.org/PathwayBrowser/#/R-DDI-70342 ALDOB tetramer cleaves Fru-1-P to GA and DHAP IEA Dictyostelium discoideum DDB_G0274375 R-DDI-71495 https://reactome.org/PathwayBrowser/#/R-DDI-71495 Aldolase tetramers convert GA3P and DHAP to F1,6PP IEA Dictyostelium discoideum DDB_G0274375 R-DDI-71496 https://reactome.org/PathwayBrowser/#/R-DDI-71496 D-fructose 1,6-bisphosphate <=> dihydroxyacetone phosphate + D-glyceraldehyde 3-phosphate IEA Dictyostelium discoideum DDB_G0274381 R-DDI-1222516 https://reactome.org/PathwayBrowser/#/R-DDI-1222516 Intraphagosomal pH is lowered to 5 by V-ATPase IEA Dictyostelium discoideum DDB_G0274381 R-DDI-6798739 https://reactome.org/PathwayBrowser/#/R-DDI-6798739 Exocytosis of azurophil granule membrane proteins IEA Dictyostelium discoideum DDB_G0274381 R-DDI-6798747 https://reactome.org/PathwayBrowser/#/R-DDI-6798747 Exocytosis of tertiary granule membrane proteins IEA Dictyostelium discoideum DDB_G0274381 R-DDI-6800426 https://reactome.org/PathwayBrowser/#/R-DDI-6800426 Exocytosis of ficolin-rich granule membrane proteins IEA Dictyostelium discoideum DDB_G0274381 R-DDI-74723 https://reactome.org/PathwayBrowser/#/R-DDI-74723 Endosome acidification IEA Dictyostelium discoideum DDB_G0274381 R-DDI-917841 https://reactome.org/PathwayBrowser/#/R-DDI-917841 Acidification of Tf:TfR1 containing endosome IEA Dictyostelium discoideum DDB_G0274381 R-DDI-9639286 https://reactome.org/PathwayBrowser/#/R-DDI-9639286 RRAGC,D exchanges GTP for GDP IEA Dictyostelium discoideum DDB_G0274381 R-DDI-9640167 https://reactome.org/PathwayBrowser/#/R-DDI-9640167 RRAGA,B exchanges GDP for GTP IEA Dictyostelium discoideum DDB_G0274381 R-DDI-9640195 https://reactome.org/PathwayBrowser/#/R-DDI-9640195 RRAGA,B hydrolyzes GTP IEA Dictyostelium discoideum DDB_G0274381 R-DDI-9645598 https://reactome.org/PathwayBrowser/#/R-DDI-9645598 RRAGC,D hydrolyzes GTP IEA Dictyostelium discoideum DDB_G0274381 R-DDI-9645608 https://reactome.org/PathwayBrowser/#/R-DDI-9645608 v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP binds mTORC1 IEA Dictyostelium discoideum DDB_G0274381 R-DDI-9646468 https://reactome.org/PathwayBrowser/#/R-DDI-9646468 mTORC1 binds RHEB:GTP IEA Dictyostelium discoideum DDB_G0274385 R-DDI-2130706 https://reactome.org/PathwayBrowser/#/R-DDI-2130706 MHC class II antigen processing IEA Dictyostelium discoideum DDB_G0274385 R-DDI-481009 https://reactome.org/PathwayBrowser/#/R-DDI-481009 Exocytosis of platelet dense granule content IEA Dictyostelium discoideum DDB_G0274391 R-DDI-5693807 https://reactome.org/PathwayBrowser/#/R-DDI-5693807 FUCA1 hydrolyses NGP:1,6-GlcNAc IEA Dictyostelium discoideum DDB_G0274391 R-DDI-6798751 https://reactome.org/PathwayBrowser/#/R-DDI-6798751 Exocytosis of azurophil granule lumen proteins IEA Dictyostelium discoideum DDB_G0274407 R-DDI-9838081 https://reactome.org/PathwayBrowser/#/R-DDI-9838081 LONP1 degrades mitochondrial matrix proteins IEA Dictyostelium discoideum DDB_G0274407 R-DDI-9838093 https://reactome.org/PathwayBrowser/#/R-DDI-9838093 LONP1 binds mitochondrial matrix proteins IEA Dictyostelium discoideum DDB_G0274409 R-DDI-351947 https://reactome.org/PathwayBrowser/#/R-DDI-351947 Nuclear translocation of catalytic domain of Mst3 IEA Dictyostelium discoideum DDB_G0274437 R-DDI-9018787 https://reactome.org/PathwayBrowser/#/R-DDI-9018787 RHOBTB2 binds interacting proteins at the endosome membrane IEA Dictyostelium discoideum DDB_G0274445 R-DDI-1675883 https://reactome.org/PathwayBrowser/#/R-DDI-1675883 PI is phosphorylated to PI4P by PI4KB at the Golgi membrane IEA Dictyostelium discoideum DDB_G0274445 R-DDI-1676152 https://reactome.org/PathwayBrowser/#/R-DDI-1676152 PI4KB binds to ARF1/3:GTP at the Golgi membrane IEA Dictyostelium discoideum DDB_G0274445 R-DDI-350769 https://reactome.org/PathwayBrowser/#/R-DDI-350769 trans-Golgi Network Coat Activation IEA Dictyostelium discoideum DDB_G0274445 R-DDI-5623508 https://reactome.org/PathwayBrowser/#/R-DDI-5623508 GBF1 stimulates nucleotide exchange on ARF4 IEA Dictyostelium discoideum DDB_G0274445 R-DDI-6807866 https://reactome.org/PathwayBrowser/#/R-DDI-6807866 GBF1 recruits ARF:GDP to the ERGIC IEA Dictyostelium discoideum DDB_G0274445 R-DDI-6807868 https://reactome.org/PathwayBrowser/#/R-DDI-6807868 GBF1 stimulates ARF nucleotide exchange IEA Dictyostelium discoideum DDB_G0274445 R-DDI-6807872 https://reactome.org/PathwayBrowser/#/R-DDI-6807872 Active ARF recruits coatomer IEA Dictyostelium discoideum DDB_G0274445 R-DDI-6807875 https://reactome.org/PathwayBrowser/#/R-DDI-6807875 ARFGAP, cargo, v-SNAREs and p24 proteins bind nascent COPI complex IEA Dictyostelium discoideum DDB_G0274445 R-DDI-6807877 https://reactome.org/PathwayBrowser/#/R-DDI-6807877 ARFGAPs stimulate ARF GTPase activity IEA Dictyostelium discoideum DDB_G0274445 R-DDI-6811411 https://reactome.org/PathwayBrowser/#/R-DDI-6811411 GBF1 recruits ARF:GDP to the Golgi IEA Dictyostelium discoideum DDB_G0274445 R-DDI-6811412 https://reactome.org/PathwayBrowser/#/R-DDI-6811412 Active ARF recruits coatomer to the Golgi IEA Dictyostelium discoideum DDB_G0274445 R-DDI-6811414 https://reactome.org/PathwayBrowser/#/R-DDI-6811414 GBF1 stimulates nucleotide exchange on ARF IEA Dictyostelium discoideum DDB_G0274445 R-DDI-6811417 https://reactome.org/PathwayBrowser/#/R-DDI-6811417 ARFGAP, cargo, vSNARES and p24 proteins bind COPI vesicles at Golgi IEA Dictyostelium discoideum DDB_G0274445 R-DDI-6811418 https://reactome.org/PathwayBrowser/#/R-DDI-6811418 ARFGAPs stimulate ARF GTPase activity at the Golgi membrane IEA Dictyostelium discoideum DDB_G0274445 R-DDI-8847880 https://reactome.org/PathwayBrowser/#/R-DDI-8847880 CYTH proteins bind ARF1:GTP IEA Dictyostelium discoideum DDB_G0274445 R-DDI-8847883 https://reactome.org/PathwayBrowser/#/R-DDI-8847883 CYTH proteins stimulate ARF1 GTPase activity IEA Dictyostelium discoideum DDB_G0274447 R-DDI-9907919 https://reactome.org/PathwayBrowser/#/R-DDI-9907919 Formation of the preholoproteasome IEA Dictyostelium discoideum DDB_G0274447 R-DDI-9907925 https://reactome.org/PathwayBrowser/#/R-DDI-9907925 Formation of the inner ring of the 20S immunoproteasome core particle IEA Dictyostelium discoideum DDB_G0274447 R-DDI-9907928 https://reactome.org/PathwayBrowser/#/R-DDI-9907928 Formation of the inner ring of the 20S thymoproteasome core particle IEA Dictyostelium discoideum DDB_G0274447 R-DDI-9907940 https://reactome.org/PathwayBrowser/#/R-DDI-9907940 Formation of the preholothymoproteasome IEA Dictyostelium discoideum DDB_G0274447 R-DDI-9907941 https://reactome.org/PathwayBrowser/#/R-DDI-9907941 Fromation of the preholoimmunoproteasome IEA Dictyostelium discoideum DDB_G0274447 R-DDI-9908051 https://reactome.org/PathwayBrowser/#/R-DDI-9908051 PSMG1 binds PSMG2 IEA Dictyostelium discoideum DDB_G0274447 R-DDI-9908052 https://reactome.org/PathwayBrowser/#/R-DDI-9908052 PSMG1:PSMG2 dimer binds the 20S core particle outer ring IEA Dictyostelium discoideum DDB_G0274447 R-DDI-9908069 https://reactome.org/PathwayBrowser/#/R-DDI-9908069 POMP binds the 20S core particle outer ring IEA Dictyostelium discoideum DDB_G0274449 R-DDI-71775 https://reactome.org/PathwayBrowser/#/R-DDI-71775 SUCLG1/G2 cleaves succinyl-CoA IEA Dictyostelium discoideum DDB_G0274461 R-DDI-6798751 https://reactome.org/PathwayBrowser/#/R-DDI-6798751 Exocytosis of azurophil granule lumen proteins IEA Dictyostelium discoideum DDB_G0274471 R-DDI-70454 https://reactome.org/PathwayBrowser/#/R-DDI-70454 dihydroxyacetone phosphate <=> D-glyceraldehyde 3-phosphate IEA Dictyostelium discoideum DDB_G0274471 R-DDI-70481 https://reactome.org/PathwayBrowser/#/R-DDI-70481 TPI1 isomerizes GA3P to DHAP IEA Dictyostelium discoideum DDB_G0274493 R-DDI-110371 https://reactome.org/PathwayBrowser/#/R-DDI-110371 LIG1 binds APEX1 and PCNA at SSB IEA Dictyostelium discoideum DDB_G0274493 R-DDI-5358592 https://reactome.org/PathwayBrowser/#/R-DDI-5358592 DNA ligase I ligates single stranded nick in double stranded DNA IEA Dictyostelium discoideum DDB_G0274493 R-DDI-5651773 https://reactome.org/PathwayBrowser/#/R-DDI-5651773 LIG1 binds POLB at long-patch BER site IEA Dictyostelium discoideum DDB_G0274493 R-DDI-5651789 https://reactome.org/PathwayBrowser/#/R-DDI-5651789 LIG1 bound to POLB ligates SSB IEA Dictyostelium discoideum DDB_G0274493 R-DDI-5651805 https://reactome.org/PathwayBrowser/#/R-DDI-5651805 LIG1 bound to APEX1 and PCNA ligates SSB IEA Dictyostelium discoideum DDB_G0274493 R-DDI-6782227 https://reactome.org/PathwayBrowser/#/R-DDI-6782227 Ligation of newly synthesized repair patch to incised DNA in TC-NER IEA Dictyostelium discoideum DDB_G0274493 R-DDI-69173 https://reactome.org/PathwayBrowser/#/R-DDI-69173 Joining of adjacent Okazaki fragments IEA Dictyostelium discoideum DDB_G0274501 R-DDI-70634 https://reactome.org/PathwayBrowser/#/R-DDI-70634 ornithine (cytosolic) + citrulline (mitochondrial) => ornithine (mitochondrial) + citrulline (cytosolic) IEA Dictyostelium discoideum DDB_G0274503 R-DDI-156678 https://reactome.org/PathwayBrowser/#/R-DDI-156678 Activation of Cdc25C IEA Dictyostelium discoideum DDB_G0274503 R-DDI-156682 https://reactome.org/PathwayBrowser/#/R-DDI-156682 PLK1 phosphorylates NUDC IEA Dictyostelium discoideum DDB_G0274503 R-DDI-156699 https://reactome.org/PathwayBrowser/#/R-DDI-156699 Inactivation of Wee1 kinase IEA Dictyostelium discoideum DDB_G0274503 R-DDI-162657 https://reactome.org/PathwayBrowser/#/R-DDI-162657 Inactivation of Myt1 kinase IEA Dictyostelium discoideum DDB_G0274503 R-DDI-174088 https://reactome.org/PathwayBrowser/#/R-DDI-174088 Association of cell cycle proteins with the APC/C:Cdh1 complex IEA Dictyostelium discoideum DDB_G0274503 R-DDI-174105 https://reactome.org/PathwayBrowser/#/R-DDI-174105 Degradation of multiubiquitinated cell cycle proteins IEA Dictyostelium discoideum DDB_G0274503 R-DDI-174119 https://reactome.org/PathwayBrowser/#/R-DDI-174119 Free APC/C phosphorylated by Plk1 IEA Dictyostelium discoideum DDB_G0274503 R-DDI-174195 https://reactome.org/PathwayBrowser/#/R-DDI-174195 Ubiquitination of cell cycle proteins targeted by the APC/C:Cdh1complex IEA Dictyostelium discoideum DDB_G0274503 R-DDI-2214351 https://reactome.org/PathwayBrowser/#/R-DDI-2214351 PLK1 phosphorylates GORASP1 IEA Dictyostelium discoideum DDB_G0274503 R-DDI-2294580 https://reactome.org/PathwayBrowser/#/R-DDI-2294580 PLK1 hyperphosphorylates Condensin II complex IEA Dictyostelium discoideum DDB_G0274503 R-DDI-2294590 https://reactome.org/PathwayBrowser/#/R-DDI-2294590 PLK1 binds phosphorylated condensin II complex IEA Dictyostelium discoideum DDB_G0274503 R-DDI-2466068 https://reactome.org/PathwayBrowser/#/R-DDI-2466068 Phosphorylation of cohesin by PLK1 at chromosomal arms IEA Dictyostelium discoideum DDB_G0274503 R-DDI-3002798 https://reactome.org/PathwayBrowser/#/R-DDI-3002798 Cytosolic PLK1 translocates to the nucleus IEA Dictyostelium discoideum DDB_G0274503 R-DDI-6802973 https://reactome.org/PathwayBrowser/#/R-DDI-6802973 PLK3 phosphorylates CDC25C IEA Dictyostelium discoideum DDB_G0274503 R-DDI-9853385 https://reactome.org/PathwayBrowser/#/R-DDI-9853385 PPP1CC dephosphorylates PLK1 IEA Dictyostelium discoideum DDB_G0274517 R-DDI-8867876 https://reactome.org/PathwayBrowser/#/R-DDI-8867876 OSBPL5,8,10 exchange PS with PI4P from ER membrane to plasma membrane IEA Dictyostelium discoideum DDB_G0274517 R-DDI-9018758 https://reactome.org/PathwayBrowser/#/R-DDI-9018758 RHOH binds effectors at the plasma membrane IEA Dictyostelium discoideum DDB_G0274519 R-DDI-2029466 https://reactome.org/PathwayBrowser/#/R-DDI-2029466 (WASPs, WAVE):G-actin:ARP2/3 binds F-actin IEA Dictyostelium discoideum DDB_G0274519 R-DDI-2029469 https://reactome.org/PathwayBrowser/#/R-DDI-2029469 p-ERK phosphorylates WAVEs and ABI IEA Dictyostelium discoideum DDB_G0274519 R-DDI-2197690 https://reactome.org/PathwayBrowser/#/R-DDI-2197690 Detachment of WASP/WAVE IEA Dictyostelium discoideum DDB_G0274519 R-DDI-6798743 https://reactome.org/PathwayBrowser/#/R-DDI-6798743 Exocytosis of secretory granule membrane proteins IEA Dictyostelium discoideum DDB_G0274519 R-DDI-6800426 https://reactome.org/PathwayBrowser/#/R-DDI-6800426 Exocytosis of ficolin-rich granule membrane proteins IEA Dictyostelium discoideum DDB_G0274519 R-DDI-9013145 https://reactome.org/PathwayBrowser/#/R-DDI-9013145 RAC1 binds effectors at the plasma membrane IEA Dictyostelium discoideum DDB_G0274519 R-DDI-9014294 https://reactome.org/PathwayBrowser/#/R-DDI-9014294 RAC2 binds effectors at the plasma membrane IEA Dictyostelium discoideum DDB_G0274519 R-DDI-9018808 https://reactome.org/PathwayBrowser/#/R-DDI-9018808 RAC3 binds effectors at the plasma membrane IEA Dictyostelium discoideum DDB_G0274525 R-DDI-176264 https://reactome.org/PathwayBrowser/#/R-DDI-176264 Recruitment of the Rad9-Hus1-Rad1 complex to DNA IEA Dictyostelium discoideum DDB_G0274537 R-DDI-8849969 https://reactome.org/PathwayBrowser/#/R-DDI-8849969 PI(4,5)P2, PI(3,4)P2 and PI(3,4,5)P3 are dephosphorylated to PI5P, PI3P and PI(3,4)P by INPP5F at the endosome membrane IEA Dictyostelium discoideum DDB_G0274553 R-DDI-1222516 https://reactome.org/PathwayBrowser/#/R-DDI-1222516 Intraphagosomal pH is lowered to 5 by V-ATPase IEA Dictyostelium discoideum DDB_G0274553 R-DDI-74723 https://reactome.org/PathwayBrowser/#/R-DDI-74723 Endosome acidification IEA Dictyostelium discoideum DDB_G0274553 R-DDI-917841 https://reactome.org/PathwayBrowser/#/R-DDI-917841 Acidification of Tf:TfR1 containing endosome IEA Dictyostelium discoideum DDB_G0274553 R-DDI-9639286 https://reactome.org/PathwayBrowser/#/R-DDI-9639286 RRAGC,D exchanges GTP for GDP IEA Dictyostelium discoideum DDB_G0274553 R-DDI-9640167 https://reactome.org/PathwayBrowser/#/R-DDI-9640167 RRAGA,B exchanges GDP for GTP IEA Dictyostelium discoideum DDB_G0274553 R-DDI-9640195 https://reactome.org/PathwayBrowser/#/R-DDI-9640195 RRAGA,B hydrolyzes GTP IEA Dictyostelium discoideum DDB_G0274553 R-DDI-9645598 https://reactome.org/PathwayBrowser/#/R-DDI-9645598 RRAGC,D hydrolyzes GTP IEA Dictyostelium discoideum DDB_G0274553 R-DDI-9645608 https://reactome.org/PathwayBrowser/#/R-DDI-9645608 v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP binds mTORC1 IEA Dictyostelium discoideum DDB_G0274553 R-DDI-9646468 https://reactome.org/PathwayBrowser/#/R-DDI-9646468 mTORC1 binds RHEB:GTP IEA Dictyostelium discoideum DDB_G0274555 R-DDI-9770236 https://reactome.org/PathwayBrowser/#/R-DDI-9770236 Formation of the Spliceosomal P complex and exon ligation IEA Dictyostelium discoideum DDB_G0274559 R-DDI-109903 https://reactome.org/PathwayBrowser/#/R-DDI-109903 cytidine or uridine + ATP => CMP or UMP + ADP [UCK2] IEA Dictyostelium discoideum DDB_G0274559 R-DDI-73599 https://reactome.org/PathwayBrowser/#/R-DDI-73599 cytidine or uridine + ATP => CMP or UMP + ADP [UCK1] IEA Dictyostelium discoideum DDB_G0274559 R-DDI-8869606 https://reactome.org/PathwayBrowser/#/R-DDI-8869606 NMRK1 phosphorylates NAR to yield NAMN IEA Dictyostelium discoideum DDB_G0274559 R-DDI-8869607 https://reactome.org/PathwayBrowser/#/R-DDI-8869607 NMRK2 phosphorylates NAR to yield NAMN IEA Dictyostelium discoideum DDB_G0274559 R-DDI-8869627 https://reactome.org/PathwayBrowser/#/R-DDI-8869627 NMRK2 phosphorylates NR to yield NMN IEA Dictyostelium discoideum DDB_G0274559 R-DDI-8869633 https://reactome.org/PathwayBrowser/#/R-DDI-8869633 NMRK1 phosphorylates NR to yield NMN IEA Dictyostelium discoideum DDB_G0274569 R-DDI-74885 https://reactome.org/PathwayBrowser/#/R-DDI-74885 GUCYs converts GTP to cGMP IEA Dictyostelium discoideum DDB_G0274591 R-DDI-446200 https://reactome.org/PathwayBrowser/#/R-DDI-446200 DOLPP1 dephosphorylates DOLDP to DOLP IEA Dictyostelium discoideum DDB_G0274593 R-DDI-9013145 https://reactome.org/PathwayBrowser/#/R-DDI-9013145 RAC1 binds effectors at the plasma membrane IEA Dictyostelium discoideum DDB_G0274593 R-DDI-9014294 https://reactome.org/PathwayBrowser/#/R-DDI-9014294 RAC2 binds effectors at the plasma membrane IEA Dictyostelium discoideum DDB_G0274593 R-DDI-9018808 https://reactome.org/PathwayBrowser/#/R-DDI-9018808 RAC3 binds effectors at the plasma membrane IEA Dictyostelium discoideum DDB_G0274595 R-DDI-6798748 https://reactome.org/PathwayBrowser/#/R-DDI-6798748 Exocytosis of secretory granule lumen proteins IEA Dictyostelium discoideum DDB_G0274595 R-DDI-6800434 https://reactome.org/PathwayBrowser/#/R-DDI-6800434 Exocytosis of ficolin-rich granule lumen proteins IEA Dictyostelium discoideum DDB_G0274595 R-DDI-76031 https://reactome.org/PathwayBrowser/#/R-DDI-76031 2 H2O2 => O2 + 2 H2O IEA Dictyostelium discoideum DDB_G0274595 R-DDI-9033235 https://reactome.org/PathwayBrowser/#/R-DDI-9033235 Cargo of PEX5S,L translocates from the cytosol to the peroxisomal matrix IEA Dictyostelium discoideum DDB_G0274595 R-DDI-9033236 https://reactome.org/PathwayBrowser/#/R-DDI-9033236 PEX5S,L:Cargo binds PEX13:PEX14:PEX2:PEX10:PEX12 (Docking and Translocation Module) IEA Dictyostelium discoideum DDB_G0274605 R-DDI-205039 https://reactome.org/PathwayBrowser/#/R-DDI-205039 p75NTR indirectly activates RAC and Cdc42 via a guanyl-nucleotide exchange factor IEA Dictyostelium discoideum DDB_G0274605 R-DDI-9013143 https://reactome.org/PathwayBrowser/#/R-DDI-9013143 RAC1 GEFs activate RAC1 IEA Dictyostelium discoideum DDB_G0274605 R-DDI-9013159 https://reactome.org/PathwayBrowser/#/R-DDI-9013159 CDC42 GEFs activate CDC42 IEA Dictyostelium discoideum DDB_G0274607 R-DDI-205039 https://reactome.org/PathwayBrowser/#/R-DDI-205039 p75NTR indirectly activates RAC and Cdc42 via a guanyl-nucleotide exchange factor IEA Dictyostelium discoideum DDB_G0274607 R-DDI-9013143 https://reactome.org/PathwayBrowser/#/R-DDI-9013143 RAC1 GEFs activate RAC1 IEA Dictyostelium discoideum DDB_G0274607 R-DDI-9013159 https://reactome.org/PathwayBrowser/#/R-DDI-9013159 CDC42 GEFs activate CDC42 IEA Dictyostelium discoideum DDB_G0274623 R-DDI-193964 https://reactome.org/PathwayBrowser/#/R-DDI-193964 CYP21A2 21-hydroxylates PROG IEA Dictyostelium discoideum DDB_G0274623 R-DDI-193981 https://reactome.org/PathwayBrowser/#/R-DDI-193981 CYP21A2 oxidises 17HPROG IEA Dictyostelium discoideum DDB_G0274627 R-DDI-156823 https://reactome.org/PathwayBrowser/#/R-DDI-156823 Association of phospho-L13a with GAIT element of Ceruloplasmin mRNA IEA Dictyostelium discoideum DDB_G0274627 R-DDI-72621 https://reactome.org/PathwayBrowser/#/R-DDI-72621 Ribosomal scanning IEA Dictyostelium discoideum DDB_G0274627 R-DDI-72676 https://reactome.org/PathwayBrowser/#/R-DDI-72676 eIF3 and eIF1A bind to the 40S subunit IEA Dictyostelium discoideum DDB_G0274627 R-DDI-72691 https://reactome.org/PathwayBrowser/#/R-DDI-72691 Formation of the 43S pre-initiation complex IEA Dictyostelium discoideum DDB_G0274627 R-DDI-72697 https://reactome.org/PathwayBrowser/#/R-DDI-72697 Start codon recognition IEA Dictyostelium discoideum DDB_G0274657 R-DDI-8878815 https://reactome.org/PathwayBrowser/#/R-DDI-8878815 Formation of 4Fe-4S cluster on ISCA1:ISCA2 IEA Dictyostelium discoideum DDB_G0274669 R-DDI-2046088 https://reactome.org/PathwayBrowser/#/R-DDI-2046088 Elongation of stearidonoyl-CoA to eicosatetraenoyl-CoA IEA Dictyostelium discoideum DDB_G0274669 R-DDI-2046094 https://reactome.org/PathwayBrowser/#/R-DDI-2046094 Elongation of gamma-lenolenoyl-CoA to dihomo-gamma-lenolenoyl-CoA IEA Dictyostelium discoideum DDB_G0274669 R-DDI-548800 https://reactome.org/PathwayBrowser/#/R-DDI-548800 ELOVL1,2,3,5 elongate AA-CoA and Mal-CoA to 3ODCT-CoA IEA Dictyostelium discoideum DDB_G0274669 R-DDI-548814 https://reactome.org/PathwayBrowser/#/R-DDI-548814 ELOVL3,6,7 elongate PALM-CoA and Mal-CoA to 3OOD-CoA IEA Dictyostelium discoideum DDB_G0274687 R-DDI-6810233 https://reactome.org/PathwayBrowser/#/R-DDI-6810233 CDK7 phosphorylates serine-5 and serine-7 of heptad repeats in C-terminal domain of RNA polymerase II at snRNA promoter IEA Dictyostelium discoideum DDB_G0274687 R-DDI-6810238 https://reactome.org/PathwayBrowser/#/R-DDI-6810238 RNA polymerase II binds initiation factors at promoter of snRNA gene (U1, U2, U4, U4atac, U5, U11, U12) IEA Dictyostelium discoideum DDB_G0274687 R-DDI-6814555 https://reactome.org/PathwayBrowser/#/R-DDI-6814555 Integrator complex processes the 3' end of snRNA IEA Dictyostelium discoideum DDB_G0274687 R-DDI-6814559 https://reactome.org/PathwayBrowser/#/R-DDI-6814559 Pre-snRNA is elongated and capped with 7-methylguanosine IEA Dictyostelium discoideum DDB_G0274695 R-DDI-8856813 https://reactome.org/PathwayBrowser/#/R-DDI-8856813 AAK1 phosphorylates AP-2 mu subunit at T156 IEA Dictyostelium discoideum DDB_G0274695 R-DDI-8868072 https://reactome.org/PathwayBrowser/#/R-DDI-8868072 Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2 IEA Dictyostelium discoideum DDB_G0274697 R-DDI-109636 https://reactome.org/PathwayBrowser/#/R-DDI-109636 Recognition and Binding of Core Promoter Elements by TFIID IEA Dictyostelium discoideum DDB_G0274697 R-DDI-109637 https://reactome.org/PathwayBrowser/#/R-DDI-109637 Binding of TFIIA and TFIIB to the pol II promoter:TFIID complex IEA Dictyostelium discoideum DDB_G0274697 R-DDI-109638 https://reactome.org/PathwayBrowser/#/R-DDI-109638 Recruitment of RNA Polymerase II Holoenzyme by TFIIF to the pol II promoter:TFIID:TFIIA:TFIIB complex IEA Dictyostelium discoideum DDB_G0274697 R-DDI-109639 https://reactome.org/PathwayBrowser/#/R-DDI-109639 Formation of the closed pre-initiation complex IEA Dictyostelium discoideum DDB_G0274697 R-DDI-73946 https://reactome.org/PathwayBrowser/#/R-DDI-73946 Abortive initiation after formation of the first phosphodiester bond IEA Dictyostelium discoideum DDB_G0274697 R-DDI-75095 https://reactome.org/PathwayBrowser/#/R-DDI-75095 Binding of TFIIE to the growing preinitiation complex IEA Dictyostelium discoideum DDB_G0274697 R-DDI-75850 https://reactome.org/PathwayBrowser/#/R-DDI-75850 Addition of the third nucleotide on the nascent transcript IEA Dictyostelium discoideum DDB_G0274697 R-DDI-75856 https://reactome.org/PathwayBrowser/#/R-DDI-75856 Abortive Initiation Before Second Transition IEA Dictyostelium discoideum DDB_G0274697 R-DDI-75861 https://reactome.org/PathwayBrowser/#/R-DDI-75861 NTP Binds Active Site of RNA Polymerase II IEA Dictyostelium discoideum DDB_G0274697 R-DDI-75862 https://reactome.org/PathwayBrowser/#/R-DDI-75862 Fall Back to Closed Pre-initiation Complex IEA Dictyostelium discoideum DDB_G0274697 R-DDI-75864 https://reactome.org/PathwayBrowser/#/R-DDI-75864 Newly Formed Phosphodiester Bond Stabilized and PPi Released IEA Dictyostelium discoideum DDB_G0274697 R-DDI-75866 https://reactome.org/PathwayBrowser/#/R-DDI-75866 Nucleophillic Attack by 3'-hydroxyl Oxygen of nascent transcript on the Alpha Phosphate of NTP IEA Dictyostelium discoideum DDB_G0274697 R-DDI-75869 https://reactome.org/PathwayBrowser/#/R-DDI-75869 Addition of the fourth nucleotide on the Nascent Transcript: Second Transition IEA Dictyostelium discoideum DDB_G0274697 R-DDI-75873 https://reactome.org/PathwayBrowser/#/R-DDI-75873 Addition of Nucleotides 5 through 9 on the growing Transcript IEA Dictyostelium discoideum DDB_G0274697 R-DDI-75949 https://reactome.org/PathwayBrowser/#/R-DDI-75949 RNA Polymerase II Promoter Opening: First Transition IEA Dictyostelium discoideum DDB_G0274697 R-DDI-9613494 https://reactome.org/PathwayBrowser/#/R-DDI-9613494 Unwinding of DNA for the Nascent Transcript: Second Transition IEA Dictyostelium discoideum DDB_G0274697 R-DDI-9613497 https://reactome.org/PathwayBrowser/#/R-DDI-9613497 Unwinding DNA for the nascent transcript IEA Dictyostelium discoideum DDB_G0274777 R-DDI-69142 https://reactome.org/PathwayBrowser/#/R-DDI-69142 Recruitment of Dna2 endonuclease IEA Dictyostelium discoideum DDB_G0274785 R-DDI-6814091 https://reactome.org/PathwayBrowser/#/R-DDI-6814091 ARL1 recruits TGN Golgin homodimers IEA Dictyostelium discoideum DDB_G0274791 R-DDI-8952039 https://reactome.org/PathwayBrowser/#/R-DDI-8952039 NEDD8:AcM-UBE2F binds CRL5 E3 ubiquitin ligase complex IEA Dictyostelium discoideum DDB_G0274791 R-DDI-8952044 https://reactome.org/PathwayBrowser/#/R-DDI-8952044 AcM-UBE2F transfers NEDD8 to CRL5 E3 ubiquitin ligase complex IEA Dictyostelium discoideum DDB_G0274791 R-DDI-8952618 https://reactome.org/PathwayBrowser/#/R-DDI-8952618 AcM-UBE2M transfers NEDD8 to CRL1 E3 ubiquitin ligase complex IEA Dictyostelium discoideum DDB_G0274791 R-DDI-8952620 https://reactome.org/PathwayBrowser/#/R-DDI-8952620 NEDD8:AcM-UBE2M binds CRL1 E3 ubiquitin ligase complex IEA Dictyostelium discoideum DDB_G0274791 R-DDI-8952626 https://reactome.org/PathwayBrowser/#/R-DDI-8952626 AcM-UBE2M transfers NEDD8 to CRL2 E3 ubiquitin ligase complex IEA Dictyostelium discoideum DDB_G0274791 R-DDI-8952630 https://reactome.org/PathwayBrowser/#/R-DDI-8952630 NEDD8:AcM-UBE2M binds CRL3 E3 ubiquitin ligase complex IEA Dictyostelium discoideum DDB_G0274791 R-DDI-8952631 https://reactome.org/PathwayBrowser/#/R-DDI-8952631 AcM-UBE2M transfers NEDD8 to CRL3 E3 ubiquitin ligase complex IEA Dictyostelium discoideum DDB_G0274791 R-DDI-8952638 https://reactome.org/PathwayBrowser/#/R-DDI-8952638 AcM-UBE2M transfers NEDD8 to CRL4 E3 ubiquitin ligase complex IEA Dictyostelium discoideum DDB_G0274791 R-DDI-8952639 https://reactome.org/PathwayBrowser/#/R-DDI-8952639 NEDD8:AcM-UBE2M binds CRL4 E3 ubiquitin ligase complex IEA Dictyostelium discoideum DDB_G0274791 R-DDI-8955285 https://reactome.org/PathwayBrowser/#/R-DDI-8955285 COMMDs displace CAND1 from CRL4 E3 ubiquitin ligase complex IEA Dictyostelium discoideum DDB_G0274791 R-DDI-8955289 https://reactome.org/PathwayBrowser/#/R-DDI-8955289 COMMDs displace CAND1 from cytosolic CRL E3 ubiquitin ligase complexes IEA Dictyostelium discoideum DDB_G0274791 R-DDI-8956040 https://reactome.org/PathwayBrowser/#/R-DDI-8956040 COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes IEA Dictyostelium discoideum DDB_G0274791 R-DDI-8956045 https://reactome.org/PathwayBrowser/#/R-DDI-8956045 COP9 signalosome deneddylates nuclear CRL4 E3 ubiquitin ligase complex IEA Dictyostelium discoideum DDB_G0274791 R-DDI-8956099 https://reactome.org/PathwayBrowser/#/R-DDI-8956099 VHL:EloB,C:NEDD8-CUL2:RBX1 complex binds UBXN7 IEA Dictyostelium discoideum DDB_G0274791 R-DDI-8956200 https://reactome.org/PathwayBrowser/#/R-DDI-8956200 MyrG-DCUN1D3 binds CRL1 E3 ubiquitin ligase complex IEA Dictyostelium discoideum DDB_G0274797 R-DDI-6782069 https://reactome.org/PathwayBrowser/#/R-DDI-6782069 UVSSA:USP7 deubiquitinates ERCC6 IEA Dictyostelium discoideum DDB_G0274797 R-DDI-6782131 https://reactome.org/PathwayBrowser/#/R-DDI-6782131 ERCC2-facilitated RNA Pol II backtracking in TC-NER IEA Dictyostelium discoideum DDB_G0274797 R-DDI-6782141 https://reactome.org/PathwayBrowser/#/R-DDI-6782141 Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in TC-NER IEA Dictyostelium discoideum DDB_G0274797 R-DDI-6782204 https://reactome.org/PathwayBrowser/#/R-DDI-6782204 5' incision of damaged DNA strand by ERCC1:ERCC4 in TC-NER IEA Dictyostelium discoideum DDB_G0274797 R-DDI-6782208 https://reactome.org/PathwayBrowser/#/R-DDI-6782208 Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in TC-NER IEA Dictyostelium discoideum DDB_G0274797 R-DDI-6782211 https://reactome.org/PathwayBrowser/#/R-DDI-6782211 DNA polymerases delta, epsilon or kappa bind the TC-NER site IEA Dictyostelium discoideum DDB_G0274797 R-DDI-6782227 https://reactome.org/PathwayBrowser/#/R-DDI-6782227 Ligation of newly synthesized repair patch to incised DNA in TC-NER IEA Dictyostelium discoideum DDB_G0274797 R-DDI-9684118 https://reactome.org/PathwayBrowser/#/R-DDI-9684118 ERCC3-facilitated RNA Pol II backtracking in TC-NER IEA Dictyostelium discoideum DDB_G0274797 R-DDI-9770236 https://reactome.org/PathwayBrowser/#/R-DDI-9770236 Formation of the Spliceosomal P complex and exon ligation IEA Dictyostelium discoideum DDB_G0274799 R-DDI-77589 https://reactome.org/PathwayBrowser/#/R-DDI-77589 Recognition of AAUAAA sequence by CPSF IEA Dictyostelium discoideum DDB_G0274799 R-DDI-77590 https://reactome.org/PathwayBrowser/#/R-DDI-77590 Recruitment of CstF to the CPSF Bound Pre-mRNA IEA Dictyostelium discoideum DDB_G0274803 R-DDI-5694409 https://reactome.org/PathwayBrowser/#/R-DDI-5694409 Nucleotide exchange on RAB1 IEA Dictyostelium discoideum DDB_G0274803 R-DDI-5694439 https://reactome.org/PathwayBrowser/#/R-DDI-5694439 COPII coat binds TRAPPCII and RAB1:GDP IEA Dictyostelium discoideum DDB_G0274803 R-DDI-5694441 https://reactome.org/PathwayBrowser/#/R-DDI-5694441 CSNK1D phosphorylates SEC23 IEA Dictyostelium discoideum DDB_G0274803 R-DDI-8877475 https://reactome.org/PathwayBrowser/#/R-DDI-8877475 TRAPPC complexes exchange GTP for GDP on RAB1 IEA Dictyostelium discoideum DDB_G0274807 R-DDI-352158 https://reactome.org/PathwayBrowser/#/R-DDI-352158 SLC16A10-mediated uptake of aromatic amino acids IEA Dictyostelium discoideum DDB_G0274807 R-DDI-879575 https://reactome.org/PathwayBrowser/#/R-DDI-879575 SLCOs, SLC16A2 transport T3,T4 from extracellular region to cytosol IEA Dictyostelium discoideum DDB_G0274809 R-DDI-164651 https://reactome.org/PathwayBrowser/#/R-DDI-164651 Electron transfer from ubiquinol to cytochrome c of complex III IEA Dictyostelium discoideum DDB_G0274809 R-DDI-9837978 https://reactome.org/PathwayBrowser/#/R-DDI-9837978 LONP1 binds mitochondrial inner membrane proteins IEA Dictyostelium discoideum DDB_G0274809 R-DDI-9838004 https://reactome.org/PathwayBrowser/#/R-DDI-9838004 LONP1 degrades mitochondrial inner membrane proteins IEA Dictyostelium discoideum DDB_G0274809 R-DDI-9838081 https://reactome.org/PathwayBrowser/#/R-DDI-9838081 LONP1 degrades mitochondrial matrix proteins IEA Dictyostelium discoideum DDB_G0274809 R-DDI-9838093 https://reactome.org/PathwayBrowser/#/R-DDI-9838093 LONP1 binds mitochondrial matrix proteins IEA Dictyostelium discoideum DDB_G0274815 R-DDI-6798747 https://reactome.org/PathwayBrowser/#/R-DDI-6798747 Exocytosis of tertiary granule membrane proteins IEA Dictyostelium discoideum DDB_G0274815 R-DDI-6800426 https://reactome.org/PathwayBrowser/#/R-DDI-6800426 Exocytosis of ficolin-rich granule membrane proteins IEA Dictyostelium discoideum DDB_G0274815 R-DDI-6809003 https://reactome.org/PathwayBrowser/#/R-DDI-6809003 ERGIC-to-Golgi vesicles bind dynein:dynactin IEA Dictyostelium discoideum DDB_G0274815 R-DDI-9646348 https://reactome.org/PathwayBrowser/#/R-DDI-9646348 PolyUb-Misfolded Proteins:HDAC6 bind dynein motor IEA Dictyostelium discoideum DDB_G0274815 R-DDI-9646685 https://reactome.org/PathwayBrowser/#/R-DDI-9646685 Aggresome dissociates from dynein and microtubule IEA Dictyostelium discoideum DDB_G0274827 R-DDI-5696600 https://reactome.org/PathwayBrowser/#/R-DDI-5696600 USP17 deubiquitinates RCE1, CDC25A, DDX58, IFIH1 IEA Dictyostelium discoideum DDB_G0274827 R-DDI-6782820 https://reactome.org/PathwayBrowser/#/R-DDI-6782820 USP17 deubiquitinates SUDS3 IEA Dictyostelium discoideum DDB_G0274829 R-DDI-9861640 https://reactome.org/PathwayBrowser/#/R-DDI-9861640 CTLH E3 ligase ubiquitinates PKM-1 IEA Dictyostelium discoideum DDB_G0274833 R-DDI-165680 https://reactome.org/PathwayBrowser/#/R-DDI-165680 Formation of active mTORC1 complex IEA Dictyostelium discoideum DDB_G0274833 R-DDI-165692 https://reactome.org/PathwayBrowser/#/R-DDI-165692 Phosphorylation of 4E-BP1 by activated mTORC1 IEA Dictyostelium discoideum DDB_G0274833 R-DDI-165718 https://reactome.org/PathwayBrowser/#/R-DDI-165718 mTORC1 phosphorylation of RPS6KB1 (S6K) IEA Dictyostelium discoideum DDB_G0274833 R-DDI-377186 https://reactome.org/PathwayBrowser/#/R-DDI-377186 Activated Akt1 phosphorylates AKT1S1 (PRAS40) IEA Dictyostelium discoideum DDB_G0274833 R-DDI-380979 https://reactome.org/PathwayBrowser/#/R-DDI-380979 RHEB in mTORC1:RHEB:GTP hydrolyses GTP IEA Dictyostelium discoideum DDB_G0274833 R-DDI-447074 https://reactome.org/PathwayBrowser/#/R-DDI-447074 AMPK phosphorylates Raptor in the mTORC1 complex IEA Dictyostelium discoideum DDB_G0274833 R-DDI-5653936 https://reactome.org/PathwayBrowser/#/R-DDI-5653936 Formation of Ragulator complex IEA Dictyostelium discoideum DDB_G0274833 R-DDI-5653968 https://reactome.org/PathwayBrowser/#/R-DDI-5653968 Ragulator:Rag dimers:SLC38A9 bind mTORC1 IEA Dictyostelium discoideum DDB_G0274833 R-DDI-5653974 https://reactome.org/PathwayBrowser/#/R-DDI-5653974 Ragulator binds Rag dimers IEA Dictyostelium discoideum DDB_G0274833 R-DDI-5672010 https://reactome.org/PathwayBrowser/#/R-DDI-5672010 Active MTORC1 phosphorylates ULK1 IEA Dictyostelium discoideum DDB_G0274833 R-DDI-5672017 https://reactome.org/PathwayBrowser/#/R-DDI-5672017 Rheb in the MTORC1 complex hydrolyses GTP IEA Dictyostelium discoideum DDB_G0274833 R-DDI-5672817 https://reactome.org/PathwayBrowser/#/R-DDI-5672817 Active MTORC1 binds the ULK1 complex IEA Dictyostelium discoideum DDB_G0274833 R-DDI-5672828 https://reactome.org/PathwayBrowser/#/R-DDI-5672828 mTORC1 phosphorylates AKT1S1 IEA Dictyostelium discoideum DDB_G0274833 R-DDI-5673768 https://reactome.org/PathwayBrowser/#/R-DDI-5673768 p-AMPK:AMP phosphorylates Raptor in the MTORC1 complex IEA Dictyostelium discoideum DDB_G0274833 R-DDI-5674130 https://reactome.org/PathwayBrowser/#/R-DDI-5674130 MAP2Ks and MAPKs are phosphorylated at the endosome membrane IEA Dictyostelium discoideum DDB_G0274833 R-DDI-5675790 https://reactome.org/PathwayBrowser/#/R-DDI-5675790 MTORC1 dissociates from ULK complex IEA Dictyostelium discoideum DDB_G0274833 R-DDI-6798747 https://reactome.org/PathwayBrowser/#/R-DDI-6798747 Exocytosis of tertiary granule membrane proteins IEA Dictyostelium discoideum DDB_G0274833 R-DDI-6799350 https://reactome.org/PathwayBrowser/#/R-DDI-6799350 Exocytosis of specific granule membrane proteins IEA Dictyostelium discoideum DDB_G0274833 R-DDI-8944454 https://reactome.org/PathwayBrowser/#/R-DDI-8944454 mTORC1 phosphorylates MAF1 IEA Dictyostelium discoideum DDB_G0274833 R-DDI-8944457 https://reactome.org/PathwayBrowser/#/R-DDI-8944457 MAF1 translocates to the nucleus IEA Dictyostelium discoideum DDB_G0274833 R-DDI-8952726 https://reactome.org/PathwayBrowser/#/R-DDI-8952726 SLC38A9 transports L-Arg from lysosomal lumen to cytosol IEA Dictyostelium discoideum DDB_G0274833 R-DDI-9639286 https://reactome.org/PathwayBrowser/#/R-DDI-9639286 RRAGC,D exchanges GTP for GDP IEA Dictyostelium discoideum DDB_G0274833 R-DDI-9640167 https://reactome.org/PathwayBrowser/#/R-DDI-9640167 RRAGA,B exchanges GDP for GTP IEA Dictyostelium discoideum DDB_G0274833 R-DDI-9640195 https://reactome.org/PathwayBrowser/#/R-DDI-9640195 RRAGA,B hydrolyzes GTP IEA Dictyostelium discoideum DDB_G0274833 R-DDI-9645598 https://reactome.org/PathwayBrowser/#/R-DDI-9645598 RRAGC,D hydrolyzes GTP IEA Dictyostelium discoideum DDB_G0274833 R-DDI-9645608 https://reactome.org/PathwayBrowser/#/R-DDI-9645608 v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP binds mTORC1 IEA Dictyostelium discoideum DDB_G0274833 R-DDI-9646468 https://reactome.org/PathwayBrowser/#/R-DDI-9646468 mTORC1 binds RHEB:GTP IEA Dictyostelium discoideum DDB_G0274859 R-DDI-3341343 https://reactome.org/PathwayBrowser/#/R-DDI-3341343 PRDX1,2,5 catalyze TXN reduced + H2O2 => TXN oxidized + 2H2O IEA Dictyostelium discoideum DDB_G0274859 R-DDI-5631885 https://reactome.org/PathwayBrowser/#/R-DDI-5631885 PRDX1 overoxidizes IEA Dictyostelium discoideum DDB_G0274859 R-DDI-5631903 https://reactome.org/PathwayBrowser/#/R-DDI-5631903 SESN1,2,3 bind overoxidized PRDX1 IEA Dictyostelium discoideum DDB_G0274859 R-DDI-6798748 https://reactome.org/PathwayBrowser/#/R-DDI-6798748 Exocytosis of secretory granule lumen proteins IEA Dictyostelium discoideum DDB_G0274859 R-DDI-6800434 https://reactome.org/PathwayBrowser/#/R-DDI-6800434 Exocytosis of ficolin-rich granule lumen proteins IEA Dictyostelium discoideum DDB_G0274871 R-DDI-191323 https://reactome.org/PathwayBrowser/#/R-DDI-191323 HMGCS1 condenses Ac-CoA and ACA-CoA to form bHMG-CoA IEA Dictyostelium discoideum DDB_G0274871 R-DDI-73918 https://reactome.org/PathwayBrowser/#/R-DDI-73918 acetoacetyl-CoA+acetyl-CoA => HMG-CoA + CoASH IEA Dictyostelium discoideum DDB_G0274871 R-DDI-9838081 https://reactome.org/PathwayBrowser/#/R-DDI-9838081 LONP1 degrades mitochondrial matrix proteins IEA Dictyostelium discoideum DDB_G0274871 R-DDI-9838093 https://reactome.org/PathwayBrowser/#/R-DDI-9838093 LONP1 binds mitochondrial matrix proteins IEA Dictyostelium discoideum DDB_G0274873 R-DDI-382613 https://reactome.org/PathwayBrowser/#/R-DDI-382613 PEX-19 docks ABCD1/D2/D3 to peroximal membrane IEA Dictyostelium discoideum DDB_G0274873 R-DDI-9603775 https://reactome.org/PathwayBrowser/#/R-DDI-9603775 PEX3:PEX19:class I PMP dissociates IEA Dictyostelium discoideum DDB_G0274873 R-DDI-9603784 https://reactome.org/PathwayBrowser/#/R-DDI-9603784 PEX19:class I PMP binds PEX3 IEA Dictyostelium discoideum DDB_G0274873 R-DDI-9603804 https://reactome.org/PathwayBrowser/#/R-DDI-9603804 PEX19 binds class I peroxisomal membrane proteins IEA Dictyostelium discoideum DDB_G0274875 R-DDI-983140 https://reactome.org/PathwayBrowser/#/R-DDI-983140 Transfer of Ub from E2 to substrate and release of E2 IEA Dictyostelium discoideum DDB_G0274875 R-DDI-983147 https://reactome.org/PathwayBrowser/#/R-DDI-983147 Release of E3 from polyubiquitinated substrate IEA Dictyostelium discoideum DDB_G0274875 R-DDI-983156 https://reactome.org/PathwayBrowser/#/R-DDI-983156 Polyubiquitination of substrate IEA Dictyostelium discoideum DDB_G0274875 R-DDI-983157 https://reactome.org/PathwayBrowser/#/R-DDI-983157 Interaction of E3 with substrate and E2-Ub complex IEA Dictyostelium discoideum DDB_G0274897 R-DDI-8852127 https://reactome.org/PathwayBrowser/#/R-DDI-8852127 UBA6 conjugates ubiquitin to cytosolic E2 enzymes IEA Dictyostelium discoideum DDB_G0274897 R-DDI-983140 https://reactome.org/PathwayBrowser/#/R-DDI-983140 Transfer of Ub from E2 to substrate and release of E2 IEA Dictyostelium discoideum DDB_G0274897 R-DDI-983152 https://reactome.org/PathwayBrowser/#/R-DDI-983152 Transfer of ubiquitin from E1 to E2 IEA Dictyostelium discoideum DDB_G0274897 R-DDI-983156 https://reactome.org/PathwayBrowser/#/R-DDI-983156 Polyubiquitination of substrate IEA Dictyostelium discoideum DDB_G0274897 R-DDI-983157 https://reactome.org/PathwayBrowser/#/R-DDI-983157 Interaction of E3 with substrate and E2-Ub complex IEA Dictyostelium discoideum DDB_G0274939 R-DDI-8875071 https://reactome.org/PathwayBrowser/#/R-DDI-8875071 ACSS3 ligates CoA to CH3COO- IEA Dictyostelium discoideum DDB_G0274953 R-DDI-73769 https://reactome.org/PathwayBrowser/#/R-DDI-73769 Loss of Rrn3 from RNA Polymerase I promoter escape complex IEA Dictyostelium discoideum DDB_G0274953 R-DDI-74986 https://reactome.org/PathwayBrowser/#/R-DDI-74986 Elongation of pre-rRNA transcript IEA Dictyostelium discoideum DDB_G0274955 R-DDI-1483222 https://reactome.org/PathwayBrowser/#/R-DDI-1483222 ETA is phosphorylated to PETA by CHK/ETNK IEA Dictyostelium discoideum DDB_G0274969 R-DDI-549112 https://reactome.org/PathwayBrowser/#/R-DDI-549112 G3P is acylated to 1-acyl LPA by AGPAT6 IEA Dictyostelium discoideum DDB_G0274969 R-DDI-75885 https://reactome.org/PathwayBrowser/#/R-DDI-75885 1-acyl LPA is acylated to PA by AGPAT (LPAAT) IEA Dictyostelium discoideum DDB_G0275005 R-DDI-6798044 https://reactome.org/PathwayBrowser/#/R-DDI-6798044 BTG2 binds CCR4-NOT complex IEA Dictyostelium discoideum DDB_G0275009 R-DDI-74885 https://reactome.org/PathwayBrowser/#/R-DDI-74885 GUCYs converts GTP to cGMP IEA Dictyostelium discoideum DDB_G0275011 R-DDI-1675928 https://reactome.org/PathwayBrowser/#/R-DDI-1675928 PI4P is phosphorylated to PI(3,4)P2 by PIK3C2A/G at the Golgi membrane IEA Dictyostelium discoideum DDB_G0275011 R-DDI-1675939 https://reactome.org/PathwayBrowser/#/R-DDI-1675939 PI is phosphorylated to PI3P by PIK3C2A/3 at the early endosome membrane IEA Dictyostelium discoideum DDB_G0275011 R-DDI-1675961 https://reactome.org/PathwayBrowser/#/R-DDI-1675961 PI is phosphorylated to PI3P by PIK3C2A/3 at the Golgi membrane IEA Dictyostelium discoideum DDB_G0275011 R-DDI-1676024 https://reactome.org/PathwayBrowser/#/R-DDI-1676024 PI is phosphorylated to PI3P by PIK3C2A/3 at the late endosome membrane IEA Dictyostelium discoideum DDB_G0275011 R-DDI-1676048 https://reactome.org/PathwayBrowser/#/R-DDI-1676048 PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane IEA Dictyostelium discoideum DDB_G0275011 R-DDI-1676109 https://reactome.org/PathwayBrowser/#/R-DDI-1676109 PI4P is phosphorylated to PI(3,4)P2 by PI3K3C[2] at the plasma membrane IEA Dictyostelium discoideum DDB_G0275011 R-DDI-1676206 https://reactome.org/PathwayBrowser/#/R-DDI-1676206 PI4P is phosphorylated to PI(3,4)P2 by PIK3C2A at the early endosome membrane IEA Dictyostelium discoideum DDB_G0275011 R-DDI-392300 https://reactome.org/PathwayBrowser/#/R-DDI-392300 G beta:gamma activated PI3Kgamma converts PIP2 to PIP3 IEA Dictyostelium discoideum DDB_G0275011 R-DDI-437162 https://reactome.org/PathwayBrowser/#/R-DDI-437162 PI3K alpha, beta, gamma convert PIP2 to PIP3 IEA Dictyostelium discoideum DDB_G0275011 R-DDI-8868072 https://reactome.org/PathwayBrowser/#/R-DDI-8868072 Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2 IEA Dictyostelium discoideum DDB_G0275017 R-DDI-3318413 https://reactome.org/PathwayBrowser/#/R-DDI-3318413 KAT7-containing ING4/5 complexes acetylate Me3K-histone H3 IEA Dictyostelium discoideum DDB_G0275017 R-DDI-3318486 https://reactome.org/PathwayBrowser/#/R-DDI-3318486 KAT6A, KAT6B-containing ING5 complexes acetylate replicative histone H3 IEA Dictyostelium discoideum DDB_G0275017 R-DDI-6805640 https://reactome.org/PathwayBrowser/#/R-DDI-6805640 AKT phosphorylates KAT6A IEA Dictyostelium discoideum DDB_G0275021 R-DDI-1358791 https://reactome.org/PathwayBrowser/#/R-DDI-1358791 Phosphorylation of USP8 by P-AKT IEA Dictyostelium discoideum DDB_G0275021 R-DDI-1358795 https://reactome.org/PathwayBrowser/#/R-DDI-1358795 Deubiquitination of RNF41 by P-USP8 IEA Dictyostelium discoideum DDB_G0275021 R-DDI-1358797 https://reactome.org/PathwayBrowser/#/R-DDI-1358797 Ubiquitinated RNF41 binds P-USP8 IEA Dictyostelium discoideum DDB_G0275029 R-DDI-5694018 https://reactome.org/PathwayBrowser/#/R-DDI-5694018 DLD dimer:2xFAD oxidises GCSH:DHLL to GCSH:lipoate IEA Dictyostelium discoideum DDB_G0275029 R-DDI-6792572 https://reactome.org/PathwayBrowser/#/R-DDI-6792572 LIPT1 transfers lipoyl group from lipoyl-GCSH to DBT/DLST IEA Dictyostelium discoideum DDB_G0275029 R-DDI-71401 https://reactome.org/PathwayBrowser/#/R-DDI-71401 OGDH dimer decarboxylates 2-OG IEA Dictyostelium discoideum DDB_G0275029 R-DDI-9853499 https://reactome.org/PathwayBrowser/#/R-DDI-9853499 DLD dimer dehydrogenates dihydrolipoyl IEA Dictyostelium discoideum DDB_G0275029 R-DDI-9853512 https://reactome.org/PathwayBrowser/#/R-DDI-9853512 DLST transfers succinyl to CoA IEA Dictyostelium discoideum DDB_G0275029 R-DDI-9858321 https://reactome.org/PathwayBrowser/#/R-DDI-9858321 DHTKD1 dimer decarboxylates 2-OA IEA Dictyostelium discoideum DDB_G0275029 R-DDI-9858589 https://reactome.org/PathwayBrowser/#/R-DDI-9858589 DLD dimer dehydrogenates dihydrolipoyl IEA Dictyostelium discoideum DDB_G0275029 R-DDI-9858590 https://reactome.org/PathwayBrowser/#/R-DDI-9858590 DLST transfers glutaryl to CoA IEA Dictyostelium discoideum DDB_G0275035 R-DDI-1011598 https://reactome.org/PathwayBrowser/#/R-DDI-1011598 DOCKs bind to RhoGEFs IEA Dictyostelium discoideum DDB_G0275035 R-DDI-9013143 https://reactome.org/PathwayBrowser/#/R-DDI-9013143 RAC1 GEFs activate RAC1 IEA Dictyostelium discoideum DDB_G0275035 R-DDI-9013159 https://reactome.org/PathwayBrowser/#/R-DDI-9013159 CDC42 GEFs activate CDC42 IEA Dictyostelium discoideum DDB_G0275035 R-DDI-9014296 https://reactome.org/PathwayBrowser/#/R-DDI-9014296 RAC2 GEFs activate RAC2 IEA Dictyostelium discoideum DDB_G0275035 R-DDI-9017491 https://reactome.org/PathwayBrowser/#/R-DDI-9017491 RHOJ GEFs activate RHOJ IEA Dictyostelium discoideum DDB_G0275035 R-DDI-9018804 https://reactome.org/PathwayBrowser/#/R-DDI-9018804 RAC3 GEFs activate RAC3 IEA Dictyostelium discoideum DDB_G0275049 R-DDI-193064 https://reactome.org/PathwayBrowser/#/R-DDI-193064 HSD17B3-like proteins reducde ANDST to TEST IEA Dictyostelium discoideum DDB_G0275049 R-DDI-548818 https://reactome.org/PathwayBrowser/#/R-DDI-548818 HSD17B3,12 hydrogenates 3OOD-CoA to 3HODC-CoA IEA Dictyostelium discoideum DDB_G0275055 R-DDI-8952039 https://reactome.org/PathwayBrowser/#/R-DDI-8952039 NEDD8:AcM-UBE2F binds CRL5 E3 ubiquitin ligase complex IEA Dictyostelium discoideum DDB_G0275055 R-DDI-8952044 https://reactome.org/PathwayBrowser/#/R-DDI-8952044 AcM-UBE2F transfers NEDD8 to CRL5 E3 ubiquitin ligase complex IEA Dictyostelium discoideum DDB_G0275055 R-DDI-8952618 https://reactome.org/PathwayBrowser/#/R-DDI-8952618 AcM-UBE2M transfers NEDD8 to CRL1 E3 ubiquitin ligase complex IEA Dictyostelium discoideum DDB_G0275055 R-DDI-8952620 https://reactome.org/PathwayBrowser/#/R-DDI-8952620 NEDD8:AcM-UBE2M binds CRL1 E3 ubiquitin ligase complex IEA Dictyostelium discoideum DDB_G0275055 R-DDI-8952626 https://reactome.org/PathwayBrowser/#/R-DDI-8952626 AcM-UBE2M transfers NEDD8 to CRL2 E3 ubiquitin ligase complex IEA Dictyostelium discoideum DDB_G0275055 R-DDI-8952630 https://reactome.org/PathwayBrowser/#/R-DDI-8952630 NEDD8:AcM-UBE2M binds CRL3 E3 ubiquitin ligase complex IEA Dictyostelium discoideum DDB_G0275055 R-DDI-8952631 https://reactome.org/PathwayBrowser/#/R-DDI-8952631 AcM-UBE2M transfers NEDD8 to CRL3 E3 ubiquitin ligase complex IEA Dictyostelium discoideum DDB_G0275055 R-DDI-8952638 https://reactome.org/PathwayBrowser/#/R-DDI-8952638 AcM-UBE2M transfers NEDD8 to CRL4 E3 ubiquitin ligase complex IEA Dictyostelium discoideum DDB_G0275055 R-DDI-8952639 https://reactome.org/PathwayBrowser/#/R-DDI-8952639 NEDD8:AcM-UBE2M binds CRL4 E3 ubiquitin ligase complex IEA Dictyostelium discoideum DDB_G0275055 R-DDI-8955285 https://reactome.org/PathwayBrowser/#/R-DDI-8955285 COMMDs displace CAND1 from CRL4 E3 ubiquitin ligase complex IEA Dictyostelium discoideum DDB_G0275055 R-DDI-8955289 https://reactome.org/PathwayBrowser/#/R-DDI-8955289 COMMDs displace CAND1 from cytosolic CRL E3 ubiquitin ligase complexes IEA Dictyostelium discoideum DDB_G0275055 R-DDI-8956040 https://reactome.org/PathwayBrowser/#/R-DDI-8956040 COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes IEA Dictyostelium discoideum DDB_G0275055 R-DDI-8956045 https://reactome.org/PathwayBrowser/#/R-DDI-8956045 COP9 signalosome deneddylates nuclear CRL4 E3 ubiquitin ligase complex IEA Dictyostelium discoideum DDB_G0275055 R-DDI-8956099 https://reactome.org/PathwayBrowser/#/R-DDI-8956099 VHL:EloB,C:NEDD8-CUL2:RBX1 complex binds UBXN7 IEA Dictyostelium discoideum DDB_G0275055 R-DDI-8956200 https://reactome.org/PathwayBrowser/#/R-DDI-8956200 MyrG-DCUN1D3 binds CRL1 E3 ubiquitin ligase complex IEA Dictyostelium discoideum DDB_G0275061 R-DDI-742354 https://reactome.org/PathwayBrowser/#/R-DDI-742354 SLC35B4 mediates the transport of UDP-N-acetylglucosamine into the Golgi lumen IEA Dictyostelium discoideum DDB_G0275061 R-DDI-742373 https://reactome.org/PathwayBrowser/#/R-DDI-742373 SLC35B4 mediates the transport of UDP-xylose into the Golgi lumen IEA Dictyostelium discoideum DDB_G0275069 R-DDI-163756 https://reactome.org/PathwayBrowser/#/R-DDI-163756 Formation of fatty acid synthase (FAS) dimer IEA Dictyostelium discoideum DDB_G0275069 R-DDI-199202 https://reactome.org/PathwayBrowser/#/R-DDI-199202 Phosphopantetheine conjugation of the ACP domain of FAS IEA Dictyostelium discoideum DDB_G0275069 R-DDI-75872 https://reactome.org/PathwayBrowser/#/R-DDI-75872 Conversion of malonyl-CoA and acetyl-CoA to palmitate IEA Dictyostelium discoideum DDB_G0275071 R-DDI-9012016 https://reactome.org/PathwayBrowser/#/R-DDI-9012016 FAHD1 dimer hydrolyses OA to PYR IEA Dictyostelium discoideum DDB_G0275077 R-DDI-163756 https://reactome.org/PathwayBrowser/#/R-DDI-163756 Formation of fatty acid synthase (FAS) dimer IEA Dictyostelium discoideum DDB_G0275077 R-DDI-199202 https://reactome.org/PathwayBrowser/#/R-DDI-199202 Phosphopantetheine conjugation of the ACP domain of FAS IEA Dictyostelium discoideum DDB_G0275077 R-DDI-75872 https://reactome.org/PathwayBrowser/#/R-DDI-75872 Conversion of malonyl-CoA and acetyl-CoA to palmitate IEA Dictyostelium discoideum DDB_G0275085 R-DDI-9013144 https://reactome.org/PathwayBrowser/#/R-DDI-9013144 RAC1 GAPs stimulate RAC1 GTPase activity IEA Dictyostelium discoideum DDB_G0275085 R-DDI-9013161 https://reactome.org/PathwayBrowser/#/R-DDI-9013161 CDC42 GAPs stimulate CDC42 GTPase activity IEA Dictyostelium discoideum DDB_G0275085 R-DDI-9018794 https://reactome.org/PathwayBrowser/#/R-DDI-9018794 RHOV binds effectors at the plasma membrane IEA Dictyostelium discoideum DDB_G0275085 R-DDI-9018806 https://reactome.org/PathwayBrowser/#/R-DDI-9018806 RAC3 GAPs stimulate RAC3 GTPase activity IEA Dictyostelium discoideum DDB_G0275113 R-DDI-6814555 https://reactome.org/PathwayBrowser/#/R-DDI-6814555 Integrator complex processes the 3' end of snRNA IEA Dictyostelium discoideum DDB_G0275113 R-DDI-6814559 https://reactome.org/PathwayBrowser/#/R-DDI-6814559 Pre-snRNA is elongated and capped with 7-methylguanosine IEA Dictyostelium discoideum DDB_G0275115 R-DDI-70994 https://reactome.org/PathwayBrowser/#/R-DDI-70994 SDH complex dehydrogenates succinate IEA Dictyostelium discoideum DDB_G0275127 R-DDI-76054 https://reactome.org/PathwayBrowser/#/R-DDI-76054 Binding of TFIIIC to TFIIIA:Type I Promoter complex IEA Dictyostelium discoideum DDB_G0275127 R-DDI-76056 https://reactome.org/PathwayBrowser/#/R-DDI-76056 Recruitment of RNA polymerase III to TFIIIB:TFIIIC:TFIIIA:Type 1 Promoter Complex IEA Dictyostelium discoideum DDB_G0275127 R-DDI-83723 https://reactome.org/PathwayBrowser/#/R-DDI-83723 Binding of TFIIIB to TFIIIC:TFIIIA:Type I Promoter complex IEA Dictyostelium discoideum DDB_G0275127 R-DDI-83788 https://reactome.org/PathwayBrowser/#/R-DDI-83788 Binding of TFIIIC to Type 2 promoter IEA Dictyostelium discoideum DDB_G0275127 R-DDI-83790 https://reactome.org/PathwayBrowser/#/R-DDI-83790 Binding of TFIIIB to TFIIC: Type 2 Promoter Complex IEA Dictyostelium discoideum DDB_G0275127 R-DDI-83805 https://reactome.org/PathwayBrowser/#/R-DDI-83805 Recruitment of RNA Polymerase III to the TFIIIB:TFIIIC: Type 2 Promoter Complex IEA Dictyostelium discoideum DDB_G0275141 R-DDI-6791222 https://reactome.org/PathwayBrowser/#/R-DDI-6791222 21S pre-rRNA is nucleolytically processed at site E (site2a) to yield 18SE pre-rRNA IEA Dictyostelium discoideum DDB_G0275141 R-DDI-6791227 https://reactome.org/PathwayBrowser/#/R-DDI-6791227 47S pre-rRNA is nucleolytically processed at A' (01,A1), site A0, and site 02 (site 6) to yield 45S pre-rRNA IEA Dictyostelium discoideum DDB_G0275145 R-DDI-5689111 https://reactome.org/PathwayBrowser/#/R-DDI-5689111 PARK2 autoubiquitinates IEA Dictyostelium discoideum DDB_G0275145 R-DDI-9641089 https://reactome.org/PathwayBrowser/#/R-DDI-9641089 Parkin binds Ub:UBE2N:UBE2V1 IEA Dictyostelium discoideum DDB_G0275145 R-DDI-9641096 https://reactome.org/PathwayBrowser/#/R-DDI-9641096 Misfolded proteins bind PRKN:UBE2N:UBE2V1:Ub IEA Dictyostelium discoideum DDB_G0275145 R-DDI-9641109 https://reactome.org/PathwayBrowser/#/R-DDI-9641109 PolyUb:misfolded proteins dissociate from PRKN:UBE2N:UBE2V1 IEA Dictyostelium discoideum DDB_G0275145 R-DDI-9641111 https://reactome.org/PathwayBrowser/#/R-DDI-9641111 Parkin transfers Ub to misfolded proteins IEA Dictyostelium discoideum DDB_G0275145 R-DDI-9641127 https://reactome.org/PathwayBrowser/#/R-DDI-9641127 Ub:misfolded proteins polymerize to PolyUb:misfolded proteins IEA Dictyostelium discoideum DDB_G0275145 R-DDI-9793472 https://reactome.org/PathwayBrowser/#/R-DDI-9793472 RIPK3 binds p-S9-PRKN IEA Dictyostelium discoideum DDB_G0275145 R-DDI-9793485 https://reactome.org/PathwayBrowser/#/R-DDI-9793485 PRKN polyubiquitinates RIPK3 IEA Dictyostelium discoideum DDB_G0275145 R-DDI-983140 https://reactome.org/PathwayBrowser/#/R-DDI-983140 Transfer of Ub from E2 to substrate and release of E2 IEA Dictyostelium discoideum DDB_G0275145 R-DDI-983147 https://reactome.org/PathwayBrowser/#/R-DDI-983147 Release of E3 from polyubiquitinated substrate IEA Dictyostelium discoideum DDB_G0275145 R-DDI-983156 https://reactome.org/PathwayBrowser/#/R-DDI-983156 Polyubiquitination of substrate IEA Dictyostelium discoideum DDB_G0275145 R-DDI-983157 https://reactome.org/PathwayBrowser/#/R-DDI-983157 Interaction of E3 with substrate and E2-Ub complex IEA Dictyostelium discoideum DDB_G0275153 R-DDI-70449 https://reactome.org/PathwayBrowser/#/R-DDI-70449 D-glyceraldehyde 3-phosphate + orthophosphate + NAD+ <=> 1,3-bisphospho-D-glycerate + NADH + H+ IEA Dictyostelium discoideum DDB_G0275153 R-DDI-70482 https://reactome.org/PathwayBrowser/#/R-DDI-70482 GAPDH tetramers reduce 1,3BPG to GA3P IEA Dictyostelium discoideum DDB_G0275167 R-DDI-1112538 https://reactome.org/PathwayBrowser/#/R-DDI-1112538 Phosphorylated STAT1, STAT3 form dimers IEA Dictyostelium discoideum DDB_G0275167 R-DDI-1112587 https://reactome.org/PathwayBrowser/#/R-DDI-1112587 STAT1 and STAT3 dimers translocate to the nucleus IEA Dictyostelium discoideum DDB_G0275167 R-DDI-1169406 https://reactome.org/PathwayBrowser/#/R-DDI-1169406 ISGylation of host proteins IEA Dictyostelium discoideum DDB_G0275167 R-DDI-3249370 https://reactome.org/PathwayBrowser/#/R-DDI-3249370 p-S407,Y641-STAT6 dimer migrates to the nucleus IEA Dictyostelium discoideum DDB_G0275167 R-DDI-3249372 https://reactome.org/PathwayBrowser/#/R-DDI-3249372 p-S407,Y641-STAT6 is dimerized IEA Dictyostelium discoideum DDB_G0275167 R-DDI-3249379 https://reactome.org/PathwayBrowser/#/R-DDI-3249379 p-S407-STAT6 is phosphorylated at Tyr641 IEA Dictyostelium discoideum DDB_G0275167 R-DDI-6784763 https://reactome.org/PathwayBrowser/#/R-DDI-6784763 p-Y705-STAT3 dimer translocates from cytosol to nucleoplasm IEA Dictyostelium discoideum DDB_G0275167 R-DDI-6784765 https://reactome.org/PathwayBrowser/#/R-DDI-6784765 p-Y705-STAT3 dimerizes IEA Dictyostelium discoideum DDB_G0275167 R-DDI-6786097 https://reactome.org/PathwayBrowser/#/R-DDI-6786097 p-Y705-STAT3, p-Y641-STAT6 dimerise IEA Dictyostelium discoideum DDB_G0275167 R-DDI-6786293 https://reactome.org/PathwayBrowser/#/R-DDI-6786293 p-Y705-STAT3 dimer, p-Y641-STAT6 dimer translocate to nucleus IEA Dictyostelium discoideum DDB_G0275167 R-DDI-6788622 https://reactome.org/PathwayBrowser/#/R-DDI-6788622 p-Y-STATs dimerize IEA Dictyostelium discoideum DDB_G0275167 R-DDI-6788623 https://reactome.org/PathwayBrowser/#/R-DDI-6788623 p-Y-STATs translocate to nucleus IEA Dictyostelium discoideum DDB_G0275167 R-DDI-6790038 https://reactome.org/PathwayBrowser/#/R-DDI-6790038 Expression of HSP90B1 IEA Dictyostelium discoideum DDB_G0275167 R-DDI-873917 https://reactome.org/PathwayBrowser/#/R-DDI-873917 Translocation of STAT1 dimer to nucleus IEA Dictyostelium discoideum DDB_G0275167 R-DDI-8950181 https://reactome.org/PathwayBrowser/#/R-DDI-8950181 Y693-STAT4 dimer translocates to the nucleus IEA Dictyostelium discoideum DDB_G0275167 R-DDI-8950522 https://reactome.org/PathwayBrowser/#/R-DDI-8950522 p-STAT1:p-STAT4 translocates to the nucleus IEA Dictyostelium discoideum DDB_G0275167 R-DDI-8950724 https://reactome.org/PathwayBrowser/#/R-DDI-8950724 p-Y705-STAT3:p-Y693-STAT4 translocates to the nucleus IEA Dictyostelium discoideum DDB_G0275167 R-DDI-8950733 https://reactome.org/PathwayBrowser/#/R-DDI-8950733 p-Y701-STAT1:p-Y705-STAT3 translocates to the nucleus IEA Dictyostelium discoideum DDB_G0275167 R-DDI-8950778 https://reactome.org/PathwayBrowser/#/R-DDI-8950778 p-Y693-STAT4 dimerizes IEA Dictyostelium discoideum DDB_G0275167 R-DDI-8950780 https://reactome.org/PathwayBrowser/#/R-DDI-8950780 p-Y705-STAT3 binds p-Y693-STAT4 IEA Dictyostelium discoideum DDB_G0275167 R-DDI-8950782 https://reactome.org/PathwayBrowser/#/R-DDI-8950782 p-STAT1 binds p-STAT3 IEA Dictyostelium discoideum DDB_G0275167 R-DDI-8983373 https://reactome.org/PathwayBrowser/#/R-DDI-8983373 p-Y-STAT3 binds p-STAT5 IEA Dictyostelium discoideum DDB_G0275167 R-DDI-8983379 https://reactome.org/PathwayBrowser/#/R-DDI-8983379 p-Y-STAT3:p-STAT5 translocates to the nucleus IEA Dictyostelium discoideum DDB_G0275167 R-DDI-8985943 https://reactome.org/PathwayBrowser/#/R-DDI-8985943 p-Y701-STAT1 dimerizes IEA Dictyostelium discoideum DDB_G0275167 R-DDI-8985950 https://reactome.org/PathwayBrowser/#/R-DDI-8985950 p-Y694-STAT5A, p-STAT5B dimerizes IEA Dictyostelium discoideum DDB_G0275167 R-DDI-8985966 https://reactome.org/PathwayBrowser/#/R-DDI-8985966 p-Y701-STAT1 binds p-Y705-STAT3 IEA Dictyostelium discoideum DDB_G0275167 R-DDI-8985981 https://reactome.org/PathwayBrowser/#/R-DDI-8985981 p-Y701-STAT1:p-Y705-STAT3 translocates from the cytosol to the nucleus IEA Dictyostelium discoideum DDB_G0275167 R-DDI-8985983 https://reactome.org/PathwayBrowser/#/R-DDI-8985983 p-Y701-STAT1 dimer translocates from the cytosol to the nucleus IEA Dictyostelium discoideum DDB_G0275167 R-DDI-8987007 https://reactome.org/PathwayBrowser/#/R-DDI-8987007 p-STAT1 dimerizes IEA Dictyostelium discoideum DDB_G0275167 R-DDI-8987052 https://reactome.org/PathwayBrowser/#/R-DDI-8987052 p-STAT3 dimer translocates from cytosol to nucleoplasm IEA Dictyostelium discoideum DDB_G0275167 R-DDI-8987214 https://reactome.org/PathwayBrowser/#/R-DDI-8987214 p-STAT3 dimerizes IEA Dictyostelium discoideum DDB_G0275167 R-DDI-8987218 https://reactome.org/PathwayBrowser/#/R-DDI-8987218 p-STAT1 dimer translocates from the cytosol to the nucleoplasm IEA Dictyostelium discoideum DDB_G0275167 R-DDI-9009072 https://reactome.org/PathwayBrowser/#/R-DDI-9009072 STAT3 phosphorylation IEA Dictyostelium discoideum DDB_G0275167 R-DDI-9701525 https://reactome.org/PathwayBrowser/#/R-DDI-9701525 p-Y705,S727-STAT3 dimerizes IEA Dictyostelium discoideum DDB_G0275167 R-DDI-9701529 https://reactome.org/PathwayBrowser/#/R-DDI-9701529 p-Y705, p-S727 STAT3 dimer translocates to the nucleus IEA Dictyostelium discoideum DDB_G0275167 R-DDI-9701565 https://reactome.org/PathwayBrowser/#/R-DDI-9701565 HDACs deacetylate p-STAT3 dimers IEA Dictyostelium discoideum DDB_G0275167 R-DDI-9710959 https://reactome.org/PathwayBrowser/#/R-DDI-9710959 p-STAT1 dimer binds KPNA1 IEA Dictyostelium discoideum DDB_G0275167 R-DDI-9865511 https://reactome.org/PathwayBrowser/#/R-DDI-9865511 Phosphorylation of STAT1 on tyrosine-701 is enhanced by p-S172-IKBKE IEA Dictyostelium discoideum DDB_G0275169 R-DDI-2534365 https://reactome.org/PathwayBrowser/#/R-DDI-2534365 Slo3 Potassium Transport IEA Dictyostelium discoideum DDB_G0275179 R-DDI-5693346 https://reactome.org/PathwayBrowser/#/R-DDI-5693346 CECRI deaminates Ade-Rib to Ino IEA Dictyostelium discoideum DDB_G0275179 R-DDI-6798751 https://reactome.org/PathwayBrowser/#/R-DDI-6798751 Exocytosis of azurophil granule lumen proteins IEA Dictyostelium discoideum DDB_G0275181 R-DDI-71020 https://reactome.org/PathwayBrowser/#/R-DDI-71020 D-methylmalonyl-CoA <=> L-methylmalonyl-CoA IEA Dictyostelium discoideum DDB_G0275185 R-DDI-9013144 https://reactome.org/PathwayBrowser/#/R-DDI-9013144 RAC1 GAPs stimulate RAC1 GTPase activity IEA Dictyostelium discoideum DDB_G0275185 R-DDI-9013161 https://reactome.org/PathwayBrowser/#/R-DDI-9013161 CDC42 GAPs stimulate CDC42 GTPase activity IEA Dictyostelium discoideum DDB_G0275185 R-DDI-9018794 https://reactome.org/PathwayBrowser/#/R-DDI-9018794 RHOV binds effectors at the plasma membrane IEA Dictyostelium discoideum DDB_G0275185 R-DDI-9018806 https://reactome.org/PathwayBrowser/#/R-DDI-9018806 RAC3 GAPs stimulate RAC3 GTPase activity IEA Dictyostelium discoideum DDB_G0275191 R-DDI-139855 https://reactome.org/PathwayBrowser/#/R-DDI-139855 P2X1-mediated entry of Ca++ from plasma IEA Dictyostelium discoideum DDB_G0275191 R-DDI-419490 https://reactome.org/PathwayBrowser/#/R-DDI-419490 Binding of ATP to P2X receptors IEA Dictyostelium discoideum DDB_G0275191 R-DDI-6798743 https://reactome.org/PathwayBrowser/#/R-DDI-6798743 Exocytosis of secretory granule membrane proteins IEA Dictyostelium discoideum DDB_G0275191 R-DDI-6799350 https://reactome.org/PathwayBrowser/#/R-DDI-6799350 Exocytosis of specific granule membrane proteins IEA Dictyostelium discoideum DDB_G0275191 R-DDI-877187 https://reactome.org/PathwayBrowser/#/R-DDI-877187 P2X7 mediates loss of intracellular K+ IEA Dictyostelium discoideum DDB_G0275197 R-DDI-143468 https://reactome.org/PathwayBrowser/#/R-DDI-143468 MEOS oxidizes ethanol to acetaldehyde IEA Dictyostelium discoideum DDB_G0275197 R-DDI-156526 https://reactome.org/PathwayBrowser/#/R-DDI-156526 CYP1A2,3A4,3A5,2A13 oxidise AFB1 to AFXBO IEA Dictyostelium discoideum DDB_G0275197 R-DDI-211874 https://reactome.org/PathwayBrowser/#/R-DDI-211874 CYP2S1 4-hydroxylates atRA IEA Dictyostelium discoideum DDB_G0275197 R-DDI-211881 https://reactome.org/PathwayBrowser/#/R-DDI-211881 Coumarin is 7-hydroxylated by CYP2A13 IEA Dictyostelium discoideum DDB_G0275197 R-DDI-211910 https://reactome.org/PathwayBrowser/#/R-DDI-211910 CYP2C8 inactivates paclitaxel by 6alpha-hydroxylation IEA Dictyostelium discoideum DDB_G0275197 R-DDI-211929 https://reactome.org/PathwayBrowser/#/R-DDI-211929 CYP2C19 5-hydroxylates omeprazole IEA Dictyostelium discoideum DDB_G0275197 R-DDI-211960 https://reactome.org/PathwayBrowser/#/R-DDI-211960 CYP2U1 19-hydroxylates ARA IEA Dictyostelium discoideum DDB_G0275197 R-DDI-211966 https://reactome.org/PathwayBrowser/#/R-DDI-211966 CYP2D6 4-hydroxylates debrisoquine IEA Dictyostelium discoideum DDB_G0275197 R-DDI-211968 https://reactome.org/PathwayBrowser/#/R-DDI-211968 CYP2W1 oxidises INDOL IEA Dictyostelium discoideum DDB_G0275197 R-DDI-211983 https://reactome.org/PathwayBrowser/#/R-DDI-211983 CYP2J2 oxidises ARA IEA Dictyostelium discoideum DDB_G0275197 R-DDI-211988 https://reactome.org/PathwayBrowser/#/R-DDI-211988 CYP2C9 inactivates tolbutamide by 4methyl-hydroxylation IEA Dictyostelium discoideum DDB_G0275197 R-DDI-211991 https://reactome.org/PathwayBrowser/#/R-DDI-211991 Cyclophosphamide is 4-hydroxylated by CYP2B6 IEA Dictyostelium discoideum DDB_G0275197 R-DDI-212004 https://reactome.org/PathwayBrowser/#/R-DDI-212004 CYP2C18 initiates bioactivation of phenytoin by 4-hydroxylation IEA Dictyostelium discoideum DDB_G0275197 R-DDI-212005 https://reactome.org/PathwayBrowser/#/R-DDI-212005 CYP2F1 dehydrogenates 3-methylindole IEA Dictyostelium discoideum DDB_G0275197 R-DDI-2161814 https://reactome.org/PathwayBrowser/#/R-DDI-2161814 Arachidonate is hydroxylated to 19-HETE by CYP(2) IEA Dictyostelium discoideum DDB_G0275197 R-DDI-2161890 https://reactome.org/PathwayBrowser/#/R-DDI-2161890 Arachidonate is epoxidated to 5,6-EET by CYP(4) IEA Dictyostelium discoideum DDB_G0275197 R-DDI-2161899 https://reactome.org/PathwayBrowser/#/R-DDI-2161899 Arachidonate is epoxidated to 8,9-EET by CYP(5) IEA Dictyostelium discoideum DDB_G0275197 R-DDI-2161940 https://reactome.org/PathwayBrowser/#/R-DDI-2161940 Arachidonate is hydroxylated to 20-HETE by CYP(3) IEA Dictyostelium discoideum DDB_G0275197 R-DDI-5423647 https://reactome.org/PathwayBrowser/#/R-DDI-5423647 CYP2A13 oxidises AFM1 to AFM1E IEA Dictyostelium discoideum DDB_G0275197 R-DDI-76354 https://reactome.org/PathwayBrowser/#/R-DDI-76354 Vinyl chloride is oxidized to 2-Chloroethylene oxide IEA Dictyostelium discoideum DDB_G0275197 R-DDI-76397 https://reactome.org/PathwayBrowser/#/R-DDI-76397 Acetaminophen oxidised to N-acetylbenzoquinoneimine (NAPQI) IEA Dictyostelium discoideum DDB_G0275197 R-DDI-76416 https://reactome.org/PathwayBrowser/#/R-DDI-76416 Benzene is hydroxylated to phenol IEA Dictyostelium discoideum DDB_G0275197 R-DDI-76434 https://reactome.org/PathwayBrowser/#/R-DDI-76434 Dehalogenation of carbon tetrachloride to form a free radical IEA Dictyostelium discoideum DDB_G0275197 R-DDI-76453 https://reactome.org/PathwayBrowser/#/R-DDI-76453 Coumarin is 7-hydroxylated by CYP2A6 IEA Dictyostelium discoideum DDB_G0275197 R-DDI-76456 https://reactome.org/PathwayBrowser/#/R-DDI-76456 O-atom dealkylation of dextromethorphan IEA Dictyostelium discoideum DDB_G0275197 R-DDI-76475 https://reactome.org/PathwayBrowser/#/R-DDI-76475 Dehalogenation of the poly-halogenated hydrocarbon Halothane to form the acylhalide Trifluoroacetlychloride and hydrogen bromide IEA Dictyostelium discoideum DDB_G0275197 R-DDI-9027043 https://reactome.org/PathwayBrowser/#/R-DDI-9027043 CYPs hydroxylate DHA to 14(R)-HDHA IEA Dictyostelium discoideum DDB_G0275197 R-DDI-9027302 https://reactome.org/PathwayBrowser/#/R-DDI-9027302 CYP2E1 oxidises 14(S)-HDHA to 14(S),21(R)-diHDHA and 14(S),21(S)-diHDHA IEA Dictyostelium discoideum DDB_G0275197 R-DDI-9027321 https://reactome.org/PathwayBrowser/#/R-DDI-9027321 CYP2E1 oxidises 14(R)-HDHA to 14(R),21(R)-diHDHA and 14(R),21(S)-diHDHA IEA Dictyostelium discoideum DDB_G0275197 R-DDI-9680865 https://reactome.org/PathwayBrowser/#/R-DDI-9680865 CYP3A4, CYP2B6 bind ritonavir IEA Dictyostelium discoideum DDB_G0275197 R-DDI-9749986 https://reactome.org/PathwayBrowser/#/R-DDI-9749986 CYP2,3 cytochromes hydroxylate ST to 2,3-DHBA IEA Dictyostelium discoideum DDB_G0275197 R-DDI-9750016 https://reactome.org/PathwayBrowser/#/R-DDI-9750016 CYP2,3 cytochromes hydroxylate ST to 2,5-DHBA IEA Dictyostelium discoideum DDB_G0275197 R-DDI-9753285 https://reactome.org/PathwayBrowser/#/R-DDI-9753285 CYP2E1 monooxygenates APAP to NAPQI IEA Dictyostelium discoideum DDB_G0275197 R-DDI-9915971 https://reactome.org/PathwayBrowser/#/R-DDI-9915971 Arachidonate is epoxidated to 11,12-EET by CYP(5) IEA Dictyostelium discoideum DDB_G0275197 R-DDI-9915997 https://reactome.org/PathwayBrowser/#/R-DDI-9915997 Arachidonate is epoxidated to 14,15-EET by CYP(5) IEA Dictyostelium discoideum DDB_G0275211 R-DDI-1799332 https://reactome.org/PathwayBrowser/#/R-DDI-1799332 Nascent polypeptide:mRNA:ribosome complex binds signal recognition particle (SRP) IEA Dictyostelium discoideum DDB_G0275235 R-DDI-1482961 https://reactome.org/PathwayBrowser/#/R-DDI-1482961 CDP-Cho and DAG are converted to PC by CEPT1 at the ER membrane IEA Dictyostelium discoideum DDB_G0275235 R-DDI-1482962 https://reactome.org/PathwayBrowser/#/R-DDI-1482962 CDP-ETA and DAG are converted to PE by CEPT1/EPT1 IEA Dictyostelium discoideum DDB_G0275235 R-DDI-1482973 https://reactome.org/PathwayBrowser/#/R-DDI-1482973 CDP-Cho and DAG are converted to PC by CHPT1 at the Golgi membrane IEA Dictyostelium discoideum DDB_G0275239 R-DDI-1011598 https://reactome.org/PathwayBrowser/#/R-DDI-1011598 DOCKs bind to RhoGEFs IEA Dictyostelium discoideum DDB_G0275239 R-DDI-9013143 https://reactome.org/PathwayBrowser/#/R-DDI-9013143 RAC1 GEFs activate RAC1 IEA Dictyostelium discoideum DDB_G0275239 R-DDI-9013159 https://reactome.org/PathwayBrowser/#/R-DDI-9013159 CDC42 GEFs activate CDC42 IEA Dictyostelium discoideum DDB_G0275239 R-DDI-9014296 https://reactome.org/PathwayBrowser/#/R-DDI-9014296 RAC2 GEFs activate RAC2 IEA Dictyostelium discoideum DDB_G0275239 R-DDI-9017491 https://reactome.org/PathwayBrowser/#/R-DDI-9017491 RHOJ GEFs activate RHOJ IEA Dictyostelium discoideum DDB_G0275239 R-DDI-9018804 https://reactome.org/PathwayBrowser/#/R-DDI-9018804 RAC3 GEFs activate RAC3 IEA Dictyostelium discoideum DDB_G0275249 R-DDI-8952039 https://reactome.org/PathwayBrowser/#/R-DDI-8952039 NEDD8:AcM-UBE2F binds CRL5 E3 ubiquitin ligase complex IEA Dictyostelium discoideum DDB_G0275249 R-DDI-8952044 https://reactome.org/PathwayBrowser/#/R-DDI-8952044 AcM-UBE2F transfers NEDD8 to CRL5 E3 ubiquitin ligase complex IEA Dictyostelium discoideum DDB_G0275249 R-DDI-8952618 https://reactome.org/PathwayBrowser/#/R-DDI-8952618 AcM-UBE2M transfers NEDD8 to CRL1 E3 ubiquitin ligase complex IEA Dictyostelium discoideum DDB_G0275249 R-DDI-8952620 https://reactome.org/PathwayBrowser/#/R-DDI-8952620 NEDD8:AcM-UBE2M binds CRL1 E3 ubiquitin ligase complex IEA Dictyostelium discoideum DDB_G0275249 R-DDI-8952626 https://reactome.org/PathwayBrowser/#/R-DDI-8952626 AcM-UBE2M transfers NEDD8 to CRL2 E3 ubiquitin ligase complex IEA Dictyostelium discoideum DDB_G0275249 R-DDI-8952630 https://reactome.org/PathwayBrowser/#/R-DDI-8952630 NEDD8:AcM-UBE2M binds CRL3 E3 ubiquitin ligase complex IEA Dictyostelium discoideum DDB_G0275249 R-DDI-8952631 https://reactome.org/PathwayBrowser/#/R-DDI-8952631 AcM-UBE2M transfers NEDD8 to CRL3 E3 ubiquitin ligase complex IEA Dictyostelium discoideum DDB_G0275249 R-DDI-8952638 https://reactome.org/PathwayBrowser/#/R-DDI-8952638 AcM-UBE2M transfers NEDD8 to CRL4 E3 ubiquitin ligase complex IEA Dictyostelium discoideum DDB_G0275249 R-DDI-8952639 https://reactome.org/PathwayBrowser/#/R-DDI-8952639 NEDD8:AcM-UBE2M binds CRL4 E3 ubiquitin ligase complex IEA Dictyostelium discoideum DDB_G0275249 R-DDI-8955285 https://reactome.org/PathwayBrowser/#/R-DDI-8955285 COMMDs displace CAND1 from CRL4 E3 ubiquitin ligase complex IEA Dictyostelium discoideum DDB_G0275249 R-DDI-8955289 https://reactome.org/PathwayBrowser/#/R-DDI-8955289 COMMDs displace CAND1 from cytosolic CRL E3 ubiquitin ligase complexes IEA Dictyostelium discoideum DDB_G0275249 R-DDI-8956040 https://reactome.org/PathwayBrowser/#/R-DDI-8956040 COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes IEA Dictyostelium discoideum DDB_G0275249 R-DDI-8956045 https://reactome.org/PathwayBrowser/#/R-DDI-8956045 COP9 signalosome deneddylates nuclear CRL4 E3 ubiquitin ligase complex IEA Dictyostelium discoideum DDB_G0275249 R-DDI-8956099 https://reactome.org/PathwayBrowser/#/R-DDI-8956099 VHL:EloB,C:NEDD8-CUL2:RBX1 complex binds UBXN7 IEA Dictyostelium discoideum DDB_G0275249 R-DDI-8956200 https://reactome.org/PathwayBrowser/#/R-DDI-8956200 MyrG-DCUN1D3 binds CRL1 E3 ubiquitin ligase complex IEA Dictyostelium discoideum DDB_G0275261 R-DDI-446189 https://reactome.org/PathwayBrowser/#/R-DDI-446189 Addition of a second glucose to the N-glycan precursor by ALG8 IEA Dictyostelium discoideum DDB_G0275265 R-DDI-1483222 https://reactome.org/PathwayBrowser/#/R-DDI-1483222 ETA is phosphorylated to PETA by CHK/ETNK IEA Dictyostelium discoideum DDB_G0275269 R-DDI-9838081 https://reactome.org/PathwayBrowser/#/R-DDI-9838081 LONP1 degrades mitochondrial matrix proteins IEA Dictyostelium discoideum DDB_G0275269 R-DDI-9838093 https://reactome.org/PathwayBrowser/#/R-DDI-9838093 LONP1 binds mitochondrial matrix proteins IEA Dictyostelium discoideum DDB_G0275293 R-DDI-139855 https://reactome.org/PathwayBrowser/#/R-DDI-139855 P2X1-mediated entry of Ca++ from plasma IEA Dictyostelium discoideum DDB_G0275293 R-DDI-419490 https://reactome.org/PathwayBrowser/#/R-DDI-419490 Binding of ATP to P2X receptors IEA Dictyostelium discoideum DDB_G0275293 R-DDI-6798743 https://reactome.org/PathwayBrowser/#/R-DDI-6798743 Exocytosis of secretory granule membrane proteins IEA Dictyostelium discoideum DDB_G0275293 R-DDI-6799350 https://reactome.org/PathwayBrowser/#/R-DDI-6799350 Exocytosis of specific granule membrane proteins IEA Dictyostelium discoideum DDB_G0275293 R-DDI-877187 https://reactome.org/PathwayBrowser/#/R-DDI-877187 P2X7 mediates loss of intracellular K+ IEA Dictyostelium discoideum DDB_G0275295 R-DDI-70369 https://reactome.org/PathwayBrowser/#/R-DDI-70369 GALE:NAD+ dimer reversibly epimerises UDP-Gal to UDP-Glc IEA Dictyostelium discoideum DDB_G0275311 R-DDI-70975 https://reactome.org/PathwayBrowser/#/R-DDI-70975 CS acetylates OA to citrate IEA Dictyostelium discoideum DDB_G0275311 R-DDI-9838081 https://reactome.org/PathwayBrowser/#/R-DDI-9838081 LONP1 degrades mitochondrial matrix proteins IEA Dictyostelium discoideum DDB_G0275311 R-DDI-9838093 https://reactome.org/PathwayBrowser/#/R-DDI-9838093 LONP1 binds mitochondrial matrix proteins IEA Dictyostelium discoideum DDB_G0275313 R-DDI-3134954 https://reactome.org/PathwayBrowser/#/R-DDI-3134954 DHX9 binds DNA IEA Dictyostelium discoideum DDB_G0275313 R-DDI-3134962 https://reactome.org/PathwayBrowser/#/R-DDI-3134962 DHX36 binds DNA IEA Dictyostelium discoideum DDB_G0275323 R-DDI-5678490 https://reactome.org/PathwayBrowser/#/R-DDI-5678490 ATG16L1 complex transfers LC3 from ATG3 to PE IEA Dictyostelium discoideum DDB_G0275323 R-DDI-5679255 https://reactome.org/PathwayBrowser/#/R-DDI-5679255 WIPI2 binds ATG12:ATG5:ATG16L IEA Dictyostelium discoideum DDB_G0275327 R-DDI-210444 https://reactome.org/PathwayBrowser/#/R-DDI-210444 L-Glutamate loading of synaptic vesicle IEA Dictyostelium discoideum DDB_G0275327 R-DDI-6798739 https://reactome.org/PathwayBrowser/#/R-DDI-6798739 Exocytosis of azurophil granule membrane proteins IEA Dictyostelium discoideum DDB_G0275327 R-DDI-6798743 https://reactome.org/PathwayBrowser/#/R-DDI-6798743 Exocytosis of secretory granule membrane proteins IEA Dictyostelium discoideum DDB_G0275327 R-DDI-8870466 https://reactome.org/PathwayBrowser/#/R-DDI-8870466 RGGT:CHM binds RABs IEA Dictyostelium discoideum DDB_G0275327 R-DDI-8870469 https://reactome.org/PathwayBrowser/#/R-DDI-8870469 RGGT geranylgeranylates RAB proteins IEA Dictyostelium discoideum DDB_G0275327 R-DDI-8876454 https://reactome.org/PathwayBrowser/#/R-DDI-8876454 DENND3 exchanges GTP for GDP on RAB12 IEA Dictyostelium discoideum DDB_G0275331 R-DDI-5694441 https://reactome.org/PathwayBrowser/#/R-DDI-5694441 CSNK1D phosphorylates SEC23 IEA Dictyostelium discoideum DDB_G0275331 R-DDI-6807864 https://reactome.org/PathwayBrowser/#/R-DDI-6807864 RAB1:GTP recruits GBF1 to the ERGIC IEA Dictyostelium discoideum DDB_G0275331 R-DDI-6807866 https://reactome.org/PathwayBrowser/#/R-DDI-6807866 GBF1 recruits ARF:GDP to the ERGIC IEA Dictyostelium discoideum DDB_G0275331 R-DDI-6807868 https://reactome.org/PathwayBrowser/#/R-DDI-6807868 GBF1 stimulates ARF nucleotide exchange IEA Dictyostelium discoideum DDB_G0275331 R-DDI-6807872 https://reactome.org/PathwayBrowser/#/R-DDI-6807872 Active ARF recruits coatomer IEA Dictyostelium discoideum DDB_G0275331 R-DDI-6807875 https://reactome.org/PathwayBrowser/#/R-DDI-6807875 ARFGAP, cargo, v-SNAREs and p24 proteins bind nascent COPI complex IEA Dictyostelium discoideum DDB_G0275331 R-DDI-6807877 https://reactome.org/PathwayBrowser/#/R-DDI-6807877 ARFGAPs stimulate ARF GTPase activity IEA Dictyostelium discoideum DDB_G0275331 R-DDI-6809003 https://reactome.org/PathwayBrowser/#/R-DDI-6809003 ERGIC-to-Golgi vesicles bind dynein:dynactin IEA Dictyostelium discoideum DDB_G0275331 R-DDI-6809011 https://reactome.org/PathwayBrowser/#/R-DDI-6809011 cis-Golgi t-SNAREs bind YKT6 on tethered vesicle IEA Dictyostelium discoideum DDB_G0275355 R-DDI-2993447 https://reactome.org/PathwayBrowser/#/R-DDI-2993447 HLCS biotinylates 6x(PCCA:PCCB) IEA Dictyostelium discoideum DDB_G0275355 R-DDI-3323111 https://reactome.org/PathwayBrowser/#/R-DDI-3323111 Cytoslic carboxylases translocate to mitochondrial matrix IEA Dictyostelium discoideum DDB_G0275355 R-DDI-71031 https://reactome.org/PathwayBrowser/#/R-DDI-71031 propionyl-CoA + CO2 + ATP <=> D-methylmalonyl-CoA + ADP + orthophosphate IEA Dictyostelium discoideum DDB_G0275381 R-DDI-9609921 https://reactome.org/PathwayBrowser/#/R-DDI-9609921 SGTA binds Tail-anchored protein IEA Dictyostelium discoideum DDB_G0275395 R-DDI-156823 https://reactome.org/PathwayBrowser/#/R-DDI-156823 Association of phospho-L13a with GAIT element of Ceruloplasmin mRNA IEA Dictyostelium discoideum DDB_G0275395 R-DDI-165766 https://reactome.org/PathwayBrowser/#/R-DDI-165766 Phosphorylation and activation of eIF4G by activated S6K1 IEA Dictyostelium discoideum DDB_G0275395 R-DDI-1678842 https://reactome.org/PathwayBrowser/#/R-DDI-1678842 Competitive inhibition of translation initiation by ISGylated 4EHP IEA Dictyostelium discoideum DDB_G0275395 R-DDI-450580 https://reactome.org/PathwayBrowser/#/R-DDI-450580 AUF1 (hnRNP D0) is ubiquitinylated IEA Dictyostelium discoideum DDB_G0275395 R-DDI-72621 https://reactome.org/PathwayBrowser/#/R-DDI-72621 Ribosomal scanning IEA Dictyostelium discoideum DDB_G0275395 R-DDI-72631 https://reactome.org/PathwayBrowser/#/R-DDI-72631 Formation of the cap-binding eIF4F complex IEA Dictyostelium discoideum DDB_G0275395 R-DDI-72697 https://reactome.org/PathwayBrowser/#/R-DDI-72697 Start codon recognition IEA Dictyostelium discoideum DDB_G0275395 R-DDI-927789 https://reactome.org/PathwayBrowser/#/R-DDI-927789 Formation of UPF1:eRF3 complex on mRNA with a premature termination codon and no Exon Junction Complex IEA Dictyostelium discoideum DDB_G0275395 R-DDI-927832 https://reactome.org/PathwayBrowser/#/R-DDI-927832 UPF1 binds an mRNP with a termination codon preceding an Exon Junction Complex IEA Dictyostelium discoideum DDB_G0275395 R-DDI-927889 https://reactome.org/PathwayBrowser/#/R-DDI-927889 SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex) IEA Dictyostelium discoideum DDB_G0275403 R-DDI-6791222 https://reactome.org/PathwayBrowser/#/R-DDI-6791222 21S pre-rRNA is nucleolytically processed at site E (site2a) to yield 18SE pre-rRNA IEA Dictyostelium discoideum DDB_G0275403 R-DDI-6791227 https://reactome.org/PathwayBrowser/#/R-DDI-6791227 47S pre-rRNA is nucleolytically processed at A' (01,A1), site A0, and site 02 (site 6) to yield 45S pre-rRNA IEA Dictyostelium discoideum DDB_G0275415 R-DDI-8853503 https://reactome.org/PathwayBrowser/#/R-DDI-8853503 UCHL3,USP7,USP9X cleaves RPS27A yielding ubiquitin IEA Dictyostelium discoideum DDB_G0275415 R-DDI-8853514 https://reactome.org/PathwayBrowser/#/R-DDI-8853514 UCHL3,USP7,USP9X cleaves UBA52 yielding ubiquitin IEA Dictyostelium discoideum DDB_G0275415 R-DDI-9018766 https://reactome.org/PathwayBrowser/#/R-DDI-9018766 RHOU binds effectors at the plasma membrane IEA Dictyostelium discoideum DDB_G0275415 R-DDI-9018794 https://reactome.org/PathwayBrowser/#/R-DDI-9018794 RHOV binds effectors at the plasma membrane IEA Dictyostelium discoideum DDB_G0275415 R-DDI-9033491 https://reactome.org/PathwayBrowser/#/R-DDI-9033491 USP9X hydrolyzes Ub:PEX5L yielding PEX5L and Ubiquitin IEA Dictyostelium discoideum DDB_G0275415 R-DDI-9033509 https://reactome.org/PathwayBrowser/#/R-DDI-9033509 USP9X binds Ub:PEX5L IEA Dictyostelium discoideum DDB_G0275417 R-DDI-6793590 https://reactome.org/PathwayBrowser/#/R-DDI-6793590 LIPT2 transfers octanoyl group to GCSH IEA Dictyostelium discoideum DDB_G0275443 R-DDI-9770236 https://reactome.org/PathwayBrowser/#/R-DDI-9770236 Formation of the Spliceosomal P complex and exon ligation IEA Dictyostelium discoideum DDB_G0275455 R-DDI-1799332 https://reactome.org/PathwayBrowser/#/R-DDI-1799332 Nascent polypeptide:mRNA:ribosome complex binds signal recognition particle (SRP) IEA Dictyostelium discoideum DDB_G0275471 R-DDI-5691006 https://reactome.org/PathwayBrowser/#/R-DDI-5691006 XPC:RAD23:CETN2 and UV-DDB bind distorted dsDNA site IEA Dictyostelium discoideum DDB_G0275471 R-DDI-6781833 https://reactome.org/PathwayBrowser/#/R-DDI-6781833 ERCC8 (CSA) binds stalled RNA Pol II IEA Dictyostelium discoideum DDB_G0275471 R-DDI-8863721 https://reactome.org/PathwayBrowser/#/R-DDI-8863721 NEDD8-STON binds TOR1 hexamer and COP9 complex IEA Dictyostelium discoideum DDB_G0275471 R-DDI-8863723 https://reactome.org/PathwayBrowser/#/R-DDI-8863723 COP9 and TOR1 deneddylate STON2 IEA Dictyostelium discoideum DDB_G0275471 R-DDI-8956040 https://reactome.org/PathwayBrowser/#/R-DDI-8956040 COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes IEA Dictyostelium discoideum DDB_G0275471 R-DDI-8956045 https://reactome.org/PathwayBrowser/#/R-DDI-8956045 COP9 signalosome deneddylates nuclear CRL4 E3 ubiquitin ligase complex IEA Dictyostelium discoideum DDB_G0275473 R-DDI-156823 https://reactome.org/PathwayBrowser/#/R-DDI-156823 Association of phospho-L13a with GAIT element of Ceruloplasmin mRNA IEA Dictyostelium discoideum DDB_G0275473 R-DDI-1799332 https://reactome.org/PathwayBrowser/#/R-DDI-1799332 Nascent polypeptide:mRNA:ribosome complex binds signal recognition particle (SRP) IEA Dictyostelium discoideum DDB_G0275473 R-DDI-72621 https://reactome.org/PathwayBrowser/#/R-DDI-72621 Ribosomal scanning IEA Dictyostelium discoideum DDB_G0275473 R-DDI-72671 https://reactome.org/PathwayBrowser/#/R-DDI-72671 eIF5B:GTP is hydrolyzed and released IEA Dictyostelium discoideum DDB_G0275473 R-DDI-72672 https://reactome.org/PathwayBrowser/#/R-DDI-72672 The 60S subunit joins the translation initiation complex IEA Dictyostelium discoideum DDB_G0275473 R-DDI-72673 https://reactome.org/PathwayBrowser/#/R-DDI-72673 Release of 40S and 60S subunits from the 80S ribosome IEA Dictyostelium discoideum DDB_G0275473 R-DDI-72676 https://reactome.org/PathwayBrowser/#/R-DDI-72676 eIF3 and eIF1A bind to the 40S subunit IEA Dictyostelium discoideum DDB_G0275473 R-DDI-72691 https://reactome.org/PathwayBrowser/#/R-DDI-72691 Formation of the 43S pre-initiation complex IEA Dictyostelium discoideum DDB_G0275473 R-DDI-72697 https://reactome.org/PathwayBrowser/#/R-DDI-72697 Start codon recognition IEA Dictyostelium discoideum DDB_G0275473 R-DDI-927789 https://reactome.org/PathwayBrowser/#/R-DDI-927789 Formation of UPF1:eRF3 complex on mRNA with a premature termination codon and no Exon Junction Complex IEA Dictyostelium discoideum DDB_G0275473 R-DDI-927832 https://reactome.org/PathwayBrowser/#/R-DDI-927832 UPF1 binds an mRNP with a termination codon preceding an Exon Junction Complex IEA Dictyostelium discoideum DDB_G0275473 R-DDI-927889 https://reactome.org/PathwayBrowser/#/R-DDI-927889 SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex) IEA Dictyostelium discoideum DDB_G0275493 R-DDI-174227 https://reactome.org/PathwayBrowser/#/R-DDI-174227 Ubiquitination of Cyclin B by phospho-APC/C:Cdc20 complex IEA Dictyostelium discoideum DDB_G0275503 R-DDI-9770236 https://reactome.org/PathwayBrowser/#/R-DDI-9770236 Formation of the Spliceosomal P complex and exon ligation IEA Dictyostelium discoideum DDB_G0275517 R-DDI-109639 https://reactome.org/PathwayBrowser/#/R-DDI-109639 Formation of the closed pre-initiation complex IEA Dictyostelium discoideum DDB_G0275517 R-DDI-111264 https://reactome.org/PathwayBrowser/#/R-DDI-111264 Addition of nucleotides between position +11 and +30 IEA Dictyostelium discoideum DDB_G0275517 R-DDI-112383 https://reactome.org/PathwayBrowser/#/R-DDI-112383 Hypophosphorylation of RNA Pol II CTD by FCP1P protein IEA Dictyostelium discoideum DDB_G0275517 R-DDI-113430 https://reactome.org/PathwayBrowser/#/R-DDI-113430 Extrusion of 5'-end of 30 nt long transcript through the pore in Pol II complex IEA Dictyostelium discoideum DDB_G0275517 R-DDI-5690996 https://reactome.org/PathwayBrowser/#/R-DDI-5690996 ERCC2 and ERCC3 DNA helicases form an open bubble structure in damaged DNA IEA Dictyostelium discoideum DDB_G0275517 R-DDI-5691000 https://reactome.org/PathwayBrowser/#/R-DDI-5691000 TFIIH binds GG-NER site to form a verification complex IEA Dictyostelium discoideum DDB_G0275517 R-DDI-6781818 https://reactome.org/PathwayBrowser/#/R-DDI-6781818 RNA Pol II initiates transcription from damaged DNA template IEA Dictyostelium discoideum DDB_G0275517 R-DDI-6781824 https://reactome.org/PathwayBrowser/#/R-DDI-6781824 Active RNA Pol II complex transcribes lesion-containing DNA template IEA Dictyostelium discoideum DDB_G0275517 R-DDI-6781833 https://reactome.org/PathwayBrowser/#/R-DDI-6781833 ERCC8 (CSA) binds stalled RNA Pol II IEA Dictyostelium discoideum DDB_G0275517 R-DDI-6781840 https://reactome.org/PathwayBrowser/#/R-DDI-6781840 ERCC6 binds stalled RNA Pol II IEA Dictyostelium discoideum DDB_G0275517 R-DDI-6781867 https://reactome.org/PathwayBrowser/#/R-DDI-6781867 ERCC8:DDB1:CUL4:RBX1 ubiquitinates ERCC6 and RNA Pol II IEA Dictyostelium discoideum DDB_G0275517 R-DDI-6782069 https://reactome.org/PathwayBrowser/#/R-DDI-6782069 UVSSA:USP7 deubiquitinates ERCC6 IEA Dictyostelium discoideum DDB_G0275517 R-DDI-6782131 https://reactome.org/PathwayBrowser/#/R-DDI-6782131 ERCC2-facilitated RNA Pol II backtracking in TC-NER IEA Dictyostelium discoideum DDB_G0275517 R-DDI-6782141 https://reactome.org/PathwayBrowser/#/R-DDI-6782141 Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in TC-NER IEA Dictyostelium discoideum DDB_G0275517 R-DDI-6782204 https://reactome.org/PathwayBrowser/#/R-DDI-6782204 5' incision of damaged DNA strand by ERCC1:ERCC4 in TC-NER IEA Dictyostelium discoideum DDB_G0275517 R-DDI-6782208 https://reactome.org/PathwayBrowser/#/R-DDI-6782208 Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in TC-NER IEA Dictyostelium discoideum DDB_G0275517 R-DDI-6782211 https://reactome.org/PathwayBrowser/#/R-DDI-6782211 DNA polymerases delta, epsilon or kappa bind the TC-NER site IEA Dictyostelium discoideum DDB_G0275517 R-DDI-6782227 https://reactome.org/PathwayBrowser/#/R-DDI-6782227 Ligation of newly synthesized repair patch to incised DNA in TC-NER IEA Dictyostelium discoideum DDB_G0275517 R-DDI-6797606 https://reactome.org/PathwayBrowser/#/R-DDI-6797606 CDK12 phosphorylates RNA Pol II CTD at DNA repair genes IEA Dictyostelium discoideum DDB_G0275517 R-DDI-6797616 https://reactome.org/PathwayBrowser/#/R-DDI-6797616 CCNK:CDK12 binds RNA Pol II at DNA repair genes IEA Dictyostelium discoideum DDB_G0275517 R-DDI-73769 https://reactome.org/PathwayBrowser/#/R-DDI-73769 Loss of Rrn3 from RNA Polymerase I promoter escape complex IEA Dictyostelium discoideum DDB_G0275517 R-DDI-73946 https://reactome.org/PathwayBrowser/#/R-DDI-73946 Abortive initiation after formation of the first phosphodiester bond IEA Dictyostelium discoideum DDB_G0275517 R-DDI-74986 https://reactome.org/PathwayBrowser/#/R-DDI-74986 Elongation of pre-rRNA transcript IEA Dictyostelium discoideum DDB_G0275517 R-DDI-75850 https://reactome.org/PathwayBrowser/#/R-DDI-75850 Addition of the third nucleotide on the nascent transcript IEA Dictyostelium discoideum DDB_G0275517 R-DDI-75856 https://reactome.org/PathwayBrowser/#/R-DDI-75856 Abortive Initiation Before Second Transition IEA Dictyostelium discoideum DDB_G0275517 R-DDI-75861 https://reactome.org/PathwayBrowser/#/R-DDI-75861 NTP Binds Active Site of RNA Polymerase II IEA Dictyostelium discoideum DDB_G0275517 R-DDI-75862 https://reactome.org/PathwayBrowser/#/R-DDI-75862 Fall Back to Closed Pre-initiation Complex IEA Dictyostelium discoideum DDB_G0275517 R-DDI-75864 https://reactome.org/PathwayBrowser/#/R-DDI-75864 Newly Formed Phosphodiester Bond Stabilized and PPi Released IEA Dictyostelium discoideum DDB_G0275517 R-DDI-75866 https://reactome.org/PathwayBrowser/#/R-DDI-75866 Nucleophillic Attack by 3'-hydroxyl Oxygen of nascent transcript on the Alpha Phosphate of NTP IEA Dictyostelium discoideum DDB_G0275517 R-DDI-75869 https://reactome.org/PathwayBrowser/#/R-DDI-75869 Addition of the fourth nucleotide on the Nascent Transcript: Second Transition IEA Dictyostelium discoideum DDB_G0275517 R-DDI-75873 https://reactome.org/PathwayBrowser/#/R-DDI-75873 Addition of Nucleotides 5 through 9 on the growing Transcript IEA Dictyostelium discoideum DDB_G0275517 R-DDI-75891 https://reactome.org/PathwayBrowser/#/R-DDI-75891 Abortive Initiation After Second Transition IEA Dictyostelium discoideum DDB_G0275517 R-DDI-75949 https://reactome.org/PathwayBrowser/#/R-DDI-75949 RNA Polymerase II Promoter Opening: First Transition IEA Dictyostelium discoideum DDB_G0275517 R-DDI-76576 https://reactome.org/PathwayBrowser/#/R-DDI-76576 Addition of nucleotides 10 and 11 on the growing transcript: Third Transition IEA Dictyostelium discoideum DDB_G0275517 R-DDI-77068 https://reactome.org/PathwayBrowser/#/R-DDI-77068 Activation of GT IEA Dictyostelium discoideum DDB_G0275517 R-DDI-77069 https://reactome.org/PathwayBrowser/#/R-DDI-77069 RNA Polymerase II CTD (phosphorylated) binds to CE IEA Dictyostelium discoideum DDB_G0275517 R-DDI-77071 https://reactome.org/PathwayBrowser/#/R-DDI-77071 Phosphorylation (Ser5) of RNA pol II CTD IEA Dictyostelium discoideum DDB_G0275517 R-DDI-77073 https://reactome.org/PathwayBrowser/#/R-DDI-77073 SPT5 subunit of Pol II binds the RNA triphosphatase (RTP) IEA Dictyostelium discoideum DDB_G0275517 R-DDI-77077 https://reactome.org/PathwayBrowser/#/R-DDI-77077 Capping complex formation IEA Dictyostelium discoideum DDB_G0275517 R-DDI-77078 https://reactome.org/PathwayBrowser/#/R-DDI-77078 Hydrolysis of the 5'-end of the nascent transcript by the capping enzyme IEA Dictyostelium discoideum DDB_G0275517 R-DDI-77081 https://reactome.org/PathwayBrowser/#/R-DDI-77081 Formation of the CE:GMP intermediate complex IEA Dictyostelium discoideum DDB_G0275517 R-DDI-77083 https://reactome.org/PathwayBrowser/#/R-DDI-77083 Transfer of GMP from the capping enzyme GT site to 5'-end of mRNA IEA Dictyostelium discoideum DDB_G0275517 R-DDI-77085 https://reactome.org/PathwayBrowser/#/R-DDI-77085 Dissociation of transcript with 5'-GMP from GT IEA Dictyostelium discoideum DDB_G0275517 R-DDI-77090 https://reactome.org/PathwayBrowser/#/R-DDI-77090 Methylation of GMP-cap by RNA Methyltransferase IEA Dictyostelium discoideum DDB_G0275517 R-DDI-9613494 https://reactome.org/PathwayBrowser/#/R-DDI-9613494 Unwinding of DNA for the Nascent Transcript: Second Transition IEA Dictyostelium discoideum DDB_G0275517 R-DDI-9613497 https://reactome.org/PathwayBrowser/#/R-DDI-9613497 Unwinding DNA for the nascent transcript IEA Dictyostelium discoideum DDB_G0275517 R-DDI-9684118 https://reactome.org/PathwayBrowser/#/R-DDI-9684118 ERCC3-facilitated RNA Pol II backtracking in TC-NER IEA Dictyostelium discoideum DDB_G0275535 R-DDI-6798747 https://reactome.org/PathwayBrowser/#/R-DDI-6798747 Exocytosis of tertiary granule membrane proteins IEA Dictyostelium discoideum DDB_G0275535 R-DDI-6799350 https://reactome.org/PathwayBrowser/#/R-DDI-6799350 Exocytosis of specific granule membrane proteins IEA Dictyostelium discoideum DDB_G0275535 R-DDI-939763 https://reactome.org/PathwayBrowser/#/R-DDI-939763 P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane IEA Dictyostelium discoideum DDB_G0275535 R-DDI-947591 https://reactome.org/PathwayBrowser/#/R-DDI-947591 P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane IEA Dictyostelium discoideum DDB_G0275537 R-DDI-114284 https://reactome.org/PathwayBrowser/#/R-DDI-114284 Release of Cytochrome c from mitochondria IEA Dictyostelium discoideum DDB_G0275537 R-DDI-164651 https://reactome.org/PathwayBrowser/#/R-DDI-164651 Electron transfer from ubiquinol to cytochrome c of complex III IEA Dictyostelium discoideum DDB_G0275537 R-DDI-3341294 https://reactome.org/PathwayBrowser/#/R-DDI-3341294 Superoxide reduces cytochrome c IEA Dictyostelium discoideum DDB_G0275537 R-DDI-5688294 https://reactome.org/PathwayBrowser/#/R-DDI-5688294 SIRT5 deacetylates Cytochrome C IEA Dictyostelium discoideum DDB_G0275537 R-DDI-9866217 https://reactome.org/PathwayBrowser/#/R-DDI-9866217 HCCS inserts heme into cytochrome c IEA Dictyostelium discoideum DDB_G0275547 R-DDI-2029468 https://reactome.org/PathwayBrowser/#/R-DDI-2029468 Conversion of PA into DAG by PAP-1 IEA Dictyostelium discoideum DDB_G0275547 R-DDI-428690 https://reactome.org/PathwayBrowser/#/R-DDI-428690 PLPP1 dephosphorylates extracellular sphingosine-1-phosphate IEA Dictyostelium discoideum DDB_G0275547 R-DDI-428696 https://reactome.org/PathwayBrowser/#/R-DDI-428696 PLPP1,2,3 dephosphorylate cytosolic sphingosine-1-phosphate IEA Dictyostelium discoideum DDB_G0275547 R-DDI-6797630 https://reactome.org/PathwayBrowser/#/R-DDI-6797630 LRPP4(LRPP1-3,5) hydrolyse LPA IEA Dictyostelium discoideum DDB_G0275557 R-DDI-5690996 https://reactome.org/PathwayBrowser/#/R-DDI-5690996 ERCC2 and ERCC3 DNA helicases form an open bubble structure in damaged DNA IEA Dictyostelium discoideum DDB_G0275557 R-DDI-5691000 https://reactome.org/PathwayBrowser/#/R-DDI-5691000 TFIIH binds GG-NER site to form a verification complex IEA Dictyostelium discoideum DDB_G0275557 R-DDI-5691004 https://reactome.org/PathwayBrowser/#/R-DDI-5691004 XPC binds RAD23 and CETN2 IEA Dictyostelium discoideum DDB_G0275557 R-DDI-5691006 https://reactome.org/PathwayBrowser/#/R-DDI-5691006 XPC:RAD23:CETN2 and UV-DDB bind distorted dsDNA site IEA Dictyostelium discoideum DDB_G0275557 R-DDI-5696655 https://reactome.org/PathwayBrowser/#/R-DDI-5696655 PARP1 or PARP2 PARylates DDB2 and autoPARylates IEA Dictyostelium discoideum DDB_G0275557 R-DDI-5696664 https://reactome.org/PathwayBrowser/#/R-DDI-5696664 PARP1 or PARP2 binds DDB2 at GG-NER site IEA Dictyostelium discoideum DDB_G0275557 R-DDI-6782943 https://reactome.org/PathwayBrowser/#/R-DDI-6782943 UV-DDB ubiquitinates XPC IEA Dictyostelium discoideum DDB_G0275567 R-DDI-351222 https://reactome.org/PathwayBrowser/#/R-DDI-351222 S-Adenosyl methionine <=> Decarboxylated-Adenosyl methionine + CO2 IEA Dictyostelium discoideum DDB_G0275573 R-DDI-5682388 https://reactome.org/PathwayBrowser/#/R-DDI-5682388 Autophagosome maturation IEA Dictyostelium discoideum DDB_G0275573 R-DDI-917693 https://reactome.org/PathwayBrowser/#/R-DDI-917693 ESCRT Disassembly IEA Dictyostelium discoideum DDB_G0275573 R-DDI-917700 https://reactome.org/PathwayBrowser/#/R-DDI-917700 MVB Vesicle Formation IEA Dictyostelium discoideum DDB_G0275573 R-DDI-9668389 https://reactome.org/PathwayBrowser/#/R-DDI-9668389 VPS4 binds ESCRT-III assemblies at nuclear envelope (NE) fenestrations IEA Dictyostelium discoideum DDB_G0275573 R-DDI-9668395 https://reactome.org/PathwayBrowser/#/R-DDI-9668395 CHMP7 binds CC2D1B IEA Dictyostelium discoideum DDB_G0275573 R-DDI-9668405 https://reactome.org/PathwayBrowser/#/R-DDI-9668405 SPAST (spastin) binds the IST1 subunit of ESCRT-III at the sites of microtubule attachment to chromatin IEA Dictyostelium discoideum DDB_G0275573 R-DDI-9668419 https://reactome.org/PathwayBrowser/#/R-DDI-9668419 SPAST (spastin) mediates the severing of microtubules at chromosome attachment sites IEA Dictyostelium discoideum DDB_G0275577 R-DDI-2161775 https://reactome.org/PathwayBrowser/#/R-DDI-2161775 ALOX12 oxidises LTA4 to LXA4 IEA Dictyostelium discoideum DDB_G0275577 R-DDI-2161794 https://reactome.org/PathwayBrowser/#/R-DDI-2161794 Arachidonate is converted to HXA3/B3 by ALOX12 IEA Dictyostelium discoideum DDB_G0275577 R-DDI-2161948 https://reactome.org/PathwayBrowser/#/R-DDI-2161948 Arachidonate is converted to 12-oxoETE by ALOX12 IEA Dictyostelium discoideum DDB_G0275577 R-DDI-2161950 https://reactome.org/PathwayBrowser/#/R-DDI-2161950 Arachidonate is oxidised to 12R-HpETE by ALOX12B IEA Dictyostelium discoideum DDB_G0275577 R-DDI-2161964 https://reactome.org/PathwayBrowser/#/R-DDI-2161964 Arachidonate is oxidised to 12S-HpETE by ALOX12/15 IEA Dictyostelium discoideum DDB_G0275577 R-DDI-2162002 https://reactome.org/PathwayBrowser/#/R-DDI-2162002 Arachidonate is oxidised to 15S-HpETE by ALOX15/15B IEA Dictyostelium discoideum DDB_G0275577 R-DDI-2162019 https://reactome.org/PathwayBrowser/#/R-DDI-2162019 LTA4 is converted to EXA4 by ALOX15 IEA Dictyostelium discoideum DDB_G0275577 R-DDI-8942208 https://reactome.org/PathwayBrowser/#/R-DDI-8942208 ALOXE3 isomerises 12R-HpETE to HXA3 IEA Dictyostelium discoideum DDB_G0275577 R-DDI-9018907 https://reactome.org/PathwayBrowser/#/R-DDI-9018907 ALOX15 oxidises 18(R)-HEPE to 18(R)-RvE3 IEA Dictyostelium discoideum DDB_G0275577 R-DDI-9020262 https://reactome.org/PathwayBrowser/#/R-DDI-9020262 ALOX15 dehydrogenates 17(R)-Hp-DHA to 17R(16)-epoxy-DHA IEA Dictyostelium discoideum DDB_G0275577 R-DDI-9020274 https://reactome.org/PathwayBrowser/#/R-DDI-9020274 ALOX12:Fe2+ oxidises DHA to 14(S)-Hp-DHA IEA Dictyostelium discoideum DDB_G0275577 R-DDI-9020275 https://reactome.org/PathwayBrowser/#/R-DDI-9020275 ALOX15 oxidises DHA to 17(S)-Hp-DHA IEA Dictyostelium discoideum DDB_G0275577 R-DDI-9020610 https://reactome.org/PathwayBrowser/#/R-DDI-9020610 ALOX15 oxidises 18(S)-HEPE to 18(S)-RvE3 IEA Dictyostelium discoideum DDB_G0275577 R-DDI-9024872 https://reactome.org/PathwayBrowser/#/R-DDI-9024872 ALOX15 oxidises 17(S)-Hp-DHA to PDX IEA Dictyostelium discoideum DDB_G0275577 R-DDI-9024881 https://reactome.org/PathwayBrowser/#/R-DDI-9024881 ALOX15 dehydrogenates 17(S)-Hp-DHA to 16S,17S-epoxy-DHA IEA Dictyostelium discoideum DDB_G0275577 R-DDI-9024983 https://reactome.org/PathwayBrowser/#/R-DDI-9024983 ALOX12:Fe2+ dehydrogenates 14(S)-Hp-DHA to 13(S),14(S)-epoxy-DHA IEA Dictyostelium discoideum DDB_G0275577 R-DDI-9025152 https://reactome.org/PathwayBrowser/#/R-DDI-9025152 ALOX15 oxidises DPAn-6 to 17(S)-HDPAn-6 and 10(S),17(S)-diHDPAn-6 IEA Dictyostelium discoideum DDB_G0275577 R-DDI-9025957 https://reactome.org/PathwayBrowser/#/R-DDI-9025957 ALOX12:Fe2+ oxidises DPAn-6 to 14(S)-HDPAn-6 IEA Dictyostelium discoideum DDB_G0275577 R-DDI-9026003 https://reactome.org/PathwayBrowser/#/R-DDI-9026003 ALOX15 oxidises DPAn-3 to 17(S)-Hp-DPAn-3 IEA Dictyostelium discoideum DDB_G0275577 R-DDI-9026006 https://reactome.org/PathwayBrowser/#/R-DDI-9026006 ALOX12:Fe2+ oxidises DPAn-3 to 14(S)-Hp-DPAn-3 IEA Dictyostelium discoideum DDB_G0275577 R-DDI-9026007 https://reactome.org/PathwayBrowser/#/R-DDI-9026007 ALOX12:Fe2+ dehydrogenates 14(S)-Hp-DPAn-3 to 13,14-epoxy-DPAn-3 IEA Dictyostelium discoideum DDB_G0275577 R-DDI-9916401 https://reactome.org/PathwayBrowser/#/R-DDI-9916401 ALOX12 oxidises LTA4 to LXB4 IEA Dictyostelium discoideum DDB_G0275617 R-DDI-109636 https://reactome.org/PathwayBrowser/#/R-DDI-109636 Recognition and Binding of Core Promoter Elements by TFIID IEA Dictyostelium discoideum DDB_G0275617 R-DDI-109637 https://reactome.org/PathwayBrowser/#/R-DDI-109637 Binding of TFIIA and TFIIB to the pol II promoter:TFIID complex IEA Dictyostelium discoideum DDB_G0275617 R-DDI-109638 https://reactome.org/PathwayBrowser/#/R-DDI-109638 Recruitment of RNA Polymerase II Holoenzyme by TFIIF to the pol II promoter:TFIID:TFIIA:TFIIB complex IEA Dictyostelium discoideum DDB_G0275617 R-DDI-109639 https://reactome.org/PathwayBrowser/#/R-DDI-109639 Formation of the closed pre-initiation complex IEA Dictyostelium discoideum DDB_G0275617 R-DDI-6810233 https://reactome.org/PathwayBrowser/#/R-DDI-6810233 CDK7 phosphorylates serine-5 and serine-7 of heptad repeats in C-terminal domain of RNA polymerase II at snRNA promoter IEA Dictyostelium discoideum DDB_G0275617 R-DDI-6810238 https://reactome.org/PathwayBrowser/#/R-DDI-6810238 RNA polymerase II binds initiation factors at promoter of snRNA gene (U1, U2, U4, U4atac, U5, U11, U12) IEA Dictyostelium discoideum DDB_G0275617 R-DDI-6814555 https://reactome.org/PathwayBrowser/#/R-DDI-6814555 Integrator complex processes the 3' end of snRNA IEA Dictyostelium discoideum DDB_G0275617 R-DDI-6814559 https://reactome.org/PathwayBrowser/#/R-DDI-6814559 Pre-snRNA is elongated and capped with 7-methylguanosine IEA Dictyostelium discoideum DDB_G0275617 R-DDI-73769 https://reactome.org/PathwayBrowser/#/R-DDI-73769 Loss of Rrn3 from RNA Polymerase I promoter escape complex IEA Dictyostelium discoideum DDB_G0275617 R-DDI-73946 https://reactome.org/PathwayBrowser/#/R-DDI-73946 Abortive initiation after formation of the first phosphodiester bond IEA Dictyostelium discoideum DDB_G0275617 R-DDI-74986 https://reactome.org/PathwayBrowser/#/R-DDI-74986 Elongation of pre-rRNA transcript IEA Dictyostelium discoideum DDB_G0275617 R-DDI-75095 https://reactome.org/PathwayBrowser/#/R-DDI-75095 Binding of TFIIE to the growing preinitiation complex IEA Dictyostelium discoideum DDB_G0275617 R-DDI-75850 https://reactome.org/PathwayBrowser/#/R-DDI-75850 Addition of the third nucleotide on the nascent transcript IEA Dictyostelium discoideum DDB_G0275617 R-DDI-75856 https://reactome.org/PathwayBrowser/#/R-DDI-75856 Abortive Initiation Before Second Transition IEA Dictyostelium discoideum DDB_G0275617 R-DDI-75861 https://reactome.org/PathwayBrowser/#/R-DDI-75861 NTP Binds Active Site of RNA Polymerase II IEA Dictyostelium discoideum DDB_G0275617 R-DDI-75862 https://reactome.org/PathwayBrowser/#/R-DDI-75862 Fall Back to Closed Pre-initiation Complex IEA Dictyostelium discoideum DDB_G0275617 R-DDI-75864 https://reactome.org/PathwayBrowser/#/R-DDI-75864 Newly Formed Phosphodiester Bond Stabilized and PPi Released IEA Dictyostelium discoideum DDB_G0275617 R-DDI-75866 https://reactome.org/PathwayBrowser/#/R-DDI-75866 Nucleophillic Attack by 3'-hydroxyl Oxygen of nascent transcript on the Alpha Phosphate of NTP IEA Dictyostelium discoideum DDB_G0275617 R-DDI-75869 https://reactome.org/PathwayBrowser/#/R-DDI-75869 Addition of the fourth nucleotide on the Nascent Transcript: Second Transition IEA Dictyostelium discoideum DDB_G0275617 R-DDI-75873 https://reactome.org/PathwayBrowser/#/R-DDI-75873 Addition of Nucleotides 5 through 9 on the growing Transcript IEA Dictyostelium discoideum DDB_G0275617 R-DDI-75949 https://reactome.org/PathwayBrowser/#/R-DDI-75949 RNA Polymerase II Promoter Opening: First Transition IEA Dictyostelium discoideum DDB_G0275617 R-DDI-76056 https://reactome.org/PathwayBrowser/#/R-DDI-76056 Recruitment of RNA polymerase III to TFIIIB:TFIIIC:TFIIIA:Type 1 Promoter Complex IEA Dictyostelium discoideum DDB_G0275617 R-DDI-83723 https://reactome.org/PathwayBrowser/#/R-DDI-83723 Binding of TFIIIB to TFIIIC:TFIIIA:Type I Promoter complex IEA Dictyostelium discoideum DDB_G0275617 R-DDI-83790 https://reactome.org/PathwayBrowser/#/R-DDI-83790 Binding of TFIIIB to TFIIC: Type 2 Promoter Complex IEA Dictyostelium discoideum DDB_G0275617 R-DDI-83805 https://reactome.org/PathwayBrowser/#/R-DDI-83805 Recruitment of RNA Polymerase III to the TFIIIB:TFIIIC: Type 2 Promoter Complex IEA Dictyostelium discoideum DDB_G0275617 R-DDI-9023860 https://reactome.org/PathwayBrowser/#/R-DDI-9023860 Histone acetyltransferases are recruited to the TFF1 gene IEA Dictyostelium discoideum DDB_G0275617 R-DDI-9613494 https://reactome.org/PathwayBrowser/#/R-DDI-9613494 Unwinding of DNA for the Nascent Transcript: Second Transition IEA Dictyostelium discoideum DDB_G0275617 R-DDI-9613497 https://reactome.org/PathwayBrowser/#/R-DDI-9613497 Unwinding DNA for the nascent transcript IEA Dictyostelium discoideum DDB_G0275619 R-DDI-9853385 https://reactome.org/PathwayBrowser/#/R-DDI-9853385 PPP1CC dephosphorylates PLK1 IEA Dictyostelium discoideum DDB_G0275623 R-DDI-68914 https://reactome.org/PathwayBrowser/#/R-DDI-68914 DNA polymerase alpha:primase binds at the origin IEA Dictyostelium discoideum DDB_G0275623 R-DDI-68917 https://reactome.org/PathwayBrowser/#/R-DDI-68917 Cdc45 associates with the pre-replicative complex at the origin IEA Dictyostelium discoideum DDB_G0275623 R-DDI-68960 https://reactome.org/PathwayBrowser/#/R-DDI-68960 DNA polymerase epsilon binds at the origin IEA Dictyostelium discoideum DDB_G0275623 R-DDI-69019 https://reactome.org/PathwayBrowser/#/R-DDI-69019 Mcm4,6,7 trimer forms and associates with the replication fork IEA Dictyostelium discoideum DDB_G0275623 R-DDI-9749253 https://reactome.org/PathwayBrowser/#/R-DDI-9749253 Formation of MCM2-7 complex IEA Dictyostelium discoideum DDB_G0275623 R-DDI-9757257 https://reactome.org/PathwayBrowser/#/R-DDI-9757257 MCM4, MCM6 and MCM7 form a heterotrimer IEA Dictyostelium discoideum DDB_G0275623 R-DDI-9757258 https://reactome.org/PathwayBrowser/#/R-DDI-9757258 MCM2 binds MCM4:MCM6:MCM7 heterotrimer IEA Dictyostelium discoideum DDB_G0275633 R-DDI-6791222 https://reactome.org/PathwayBrowser/#/R-DDI-6791222 21S pre-rRNA is nucleolytically processed at site E (site2a) to yield 18SE pre-rRNA IEA Dictyostelium discoideum DDB_G0275633 R-DDI-6791227 https://reactome.org/PathwayBrowser/#/R-DDI-6791227 47S pre-rRNA is nucleolytically processed at A' (01,A1), site A0, and site 02 (site 6) to yield 45S pre-rRNA IEA Dictyostelium discoideum DDB_G0275633 R-DDI-9770236 https://reactome.org/PathwayBrowser/#/R-DDI-9770236 Formation of the Spliceosomal P complex and exon ligation IEA Dictyostelium discoideum DDB_G0275635 R-DDI-1675773 https://reactome.org/PathwayBrowser/#/R-DDI-1675773 PI(3,4)P2 is phosphorylated to PI(3,4,5)P3 by PIP5K1A-C at the plasma membrane IEA Dictyostelium discoideum DDB_G0275635 R-DDI-1675776 https://reactome.org/PathwayBrowser/#/R-DDI-1675776 PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers at the plasma membrane IEA Dictyostelium discoideum DDB_G0275635 R-DDI-1675810 https://reactome.org/PathwayBrowser/#/R-DDI-1675810 PI is phosphorylated to PI5P by PIP5K1A/B at the plasma membrane IEA Dictyostelium discoideum DDB_G0275635 R-DDI-1676082 https://reactome.org/PathwayBrowser/#/R-DDI-1676082 PI4P is phosphorylated to PI(4,5)P2 by PIP5K1A-C at the plasma membrane IEA Dictyostelium discoideum DDB_G0275635 R-DDI-1676134 https://reactome.org/PathwayBrowser/#/R-DDI-1676134 PI3P is phosphorylated to PI(3,5)P2 by PIP5K1A/B at the plasma membrane IEA Dictyostelium discoideum DDB_G0275635 R-DDI-1676145 https://reactome.org/PathwayBrowser/#/R-DDI-1676145 PI3P is phosphorylated to PI(3,4)P2 by PIP4K2/5K1 at the plasma membrane IEA Dictyostelium discoideum DDB_G0275635 R-DDI-6811522 https://reactome.org/PathwayBrowser/#/R-DDI-6811522 PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers in the nucleus IEA Dictyostelium discoideum DDB_G0275635 R-DDI-8868066 https://reactome.org/PathwayBrowser/#/R-DDI-8868066 PIP5K1C phosphorylates PI(4)P to PI(4,5)P2 IEA Dictyostelium discoideum DDB_G0275635 R-DDI-8877691 https://reactome.org/PathwayBrowser/#/R-DDI-8877691 MAP2K6 phosphorylates PIP4K2B IEA Dictyostelium discoideum DDB_G0275635 R-DDI-8877692 https://reactome.org/PathwayBrowser/#/R-DDI-8877692 PIN1 binds phosphorylated PIP4K2B IEA Dictyostelium discoideum DDB_G0275653 R-DDI-110376 https://reactome.org/PathwayBrowser/#/R-DDI-110376 Recruitment of LIG3:XRCC1 complex to the site of repair by POLB IEA Dictyostelium discoideum DDB_G0275653 R-DDI-5649705 https://reactome.org/PathwayBrowser/#/R-DDI-5649705 PNKP hydrolyzes the terminal 3'Pi at the NEIL1,NEIL2-generated single strand break (SSB) IEA Dictyostelium discoideum DDB_G0275653 R-DDI-5649723 https://reactome.org/PathwayBrowser/#/R-DDI-5649723 POLB incorporates a single nucleotide in place of excised AP residue in NEIL1,NEIL2-mediated AP site resolution IEA Dictyostelium discoideum DDB_G0275653 R-DDI-5649734 https://reactome.org/PathwayBrowser/#/R-DDI-5649734 LIG3 ligates NEIL1,NEIL2-generated single strand break IEA Dictyostelium discoideum DDB_G0275653 R-DDI-6782227 https://reactome.org/PathwayBrowser/#/R-DDI-6782227 Ligation of newly synthesized repair patch to incised DNA in TC-NER IEA Dictyostelium discoideum DDB_G0275653 R-DDI-73931 https://reactome.org/PathwayBrowser/#/R-DDI-73931 LIG3-mediated DNA ligation via the single-nucleotide replacement pathway IEA Dictyostelium discoideum DDB_G0275653 R-DDI-73932 https://reactome.org/PathwayBrowser/#/R-DDI-73932 Resynthesis of excised residue by POLB IEA Dictyostelium discoideum DDB_G0275663 R-DDI-176606 https://reactome.org/PathwayBrowser/#/R-DDI-176606 Adenosine 3',5'-bisphosphate (PAP) + H2O => AMP + orthophosphate IEA Dictyostelium discoideum DDB_G0275663 R-DDI-1855208 https://reactome.org/PathwayBrowser/#/R-DDI-1855208 I(1,4)P2 is dephosphorylated to I4P by INPP1 in the cytosol IEA Dictyostelium discoideum DDB_G0275663 R-DDI-1855232 https://reactome.org/PathwayBrowser/#/R-DDI-1855232 I(1,3,4)P3 is dephosphorylated to I(3,4)P2 by INPP1 in the cytosol IEA Dictyostelium discoideum DDB_G0275663 R-DDI-8953499 https://reactome.org/PathwayBrowser/#/R-DDI-8953499 IMPAD1 hydrolyses PAP to AMP IEA Dictyostelium discoideum DDB_G0275665 R-DDI-8874435 https://reactome.org/PathwayBrowser/#/R-DDI-8874435 THEM86B hydrolyses PMCHO, PMETAM IEA Dictyostelium discoideum DDB_G0275669 R-DDI-6784224 https://reactome.org/PathwayBrowser/#/R-DDI-6784224 PRODH2:FAD dimer dehydrogenates HPRO to 1-pyrroline-3-hydroxy-5-carboxylate IEA Dictyostelium discoideum DDB_G0275669 R-DDI-70670 https://reactome.org/PathwayBrowser/#/R-DDI-70670 PRODH oxidises L-Pro to 1PYR-5COOH IEA Dictyostelium discoideum DDB_G0275669 R-DDI-8955817 https://reactome.org/PathwayBrowser/#/R-DDI-8955817 PRODH2 oxidises HPRO to 1PYR-5COOH IEA Dictyostelium discoideum DDB_G0275675 R-DDI-8870466 https://reactome.org/PathwayBrowser/#/R-DDI-8870466 RGGT:CHM binds RABs IEA Dictyostelium discoideum DDB_G0275675 R-DDI-8870469 https://reactome.org/PathwayBrowser/#/R-DDI-8870469 RGGT geranylgeranylates RAB proteins IEA Dictyostelium discoideum DDB_G0275701 R-DDI-1222516 https://reactome.org/PathwayBrowser/#/R-DDI-1222516 Intraphagosomal pH is lowered to 5 by V-ATPase IEA Dictyostelium discoideum DDB_G0275701 R-DDI-74723 https://reactome.org/PathwayBrowser/#/R-DDI-74723 Endosome acidification IEA Dictyostelium discoideum DDB_G0275701 R-DDI-917841 https://reactome.org/PathwayBrowser/#/R-DDI-917841 Acidification of Tf:TfR1 containing endosome IEA Dictyostelium discoideum DDB_G0275701 R-DDI-9639286 https://reactome.org/PathwayBrowser/#/R-DDI-9639286 RRAGC,D exchanges GTP for GDP IEA Dictyostelium discoideum DDB_G0275701 R-DDI-9640167 https://reactome.org/PathwayBrowser/#/R-DDI-9640167 RRAGA,B exchanges GDP for GTP IEA Dictyostelium discoideum DDB_G0275701 R-DDI-9640195 https://reactome.org/PathwayBrowser/#/R-DDI-9640195 RRAGA,B hydrolyzes GTP IEA Dictyostelium discoideum DDB_G0275701 R-DDI-9645598 https://reactome.org/PathwayBrowser/#/R-DDI-9645598 RRAGC,D hydrolyzes GTP IEA Dictyostelium discoideum DDB_G0275701 R-DDI-9645608 https://reactome.org/PathwayBrowser/#/R-DDI-9645608 v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP binds mTORC1 IEA Dictyostelium discoideum DDB_G0275701 R-DDI-9646468 https://reactome.org/PathwayBrowser/#/R-DDI-9646468 mTORC1 binds RHEB:GTP IEA Dictyostelium discoideum DDB_G0275703 R-DDI-205039 https://reactome.org/PathwayBrowser/#/R-DDI-205039 p75NTR indirectly activates RAC and Cdc42 via a guanyl-nucleotide exchange factor IEA Dictyostelium discoideum DDB_G0275703 R-DDI-9013143 https://reactome.org/PathwayBrowser/#/R-DDI-9013143 RAC1 GEFs activate RAC1 IEA Dictyostelium discoideum DDB_G0275703 R-DDI-9013159 https://reactome.org/PathwayBrowser/#/R-DDI-9013159 CDC42 GEFs activate CDC42 IEA Dictyostelium discoideum DDB_G0275711 R-DDI-425983 https://reactome.org/PathwayBrowser/#/R-DDI-425983 SLC9A6,7 exchange Na+ for H+ across the early endosome membrane IEA Dictyostelium discoideum DDB_G0275711 R-DDI-425994 https://reactome.org/PathwayBrowser/#/R-DDI-425994 Na+/H+ exchanger transport (at cell membrane) IEA Dictyostelium discoideum DDB_G0275711 R-DDI-426015 https://reactome.org/PathwayBrowser/#/R-DDI-426015 Na+/H+ exchanger transport (at trans-golgi membrane) IEA Dictyostelium discoideum DDB_G0275719 R-DDI-429860 https://reactome.org/PathwayBrowser/#/R-DDI-429860 DCP1-DCP2 complex decaps mRNA IEA Dictyostelium discoideum DDB_G0275719 R-DDI-429978 https://reactome.org/PathwayBrowser/#/R-DDI-429978 Lsm1-7 Complex binds deadenylated mRNA IEA Dictyostelium discoideum DDB_G0275741 R-DDI-209772 https://reactome.org/PathwayBrowser/#/R-DDI-209772 Thyroxine is deiodinated to triiodothyronine IEA Dictyostelium discoideum DDB_G0275741 R-DDI-350869 https://reactome.org/PathwayBrowser/#/R-DDI-350869 Thyroxine is deiodinated to reverse triiodothyronine (RT3) IEA Dictyostelium discoideum DDB_G0275753 R-DDI-9907965 https://reactome.org/PathwayBrowser/#/R-DDI-9907965 PSMD9 binds PSMC3:PSMC6 IEA Dictyostelium discoideum DDB_G0275753 R-DDI-9907980 https://reactome.org/PathwayBrowser/#/R-DDI-9907980 Formation of the 19S regulatory particle base precursor IEA Dictyostelium discoideum DDB_G0275759 R-DDI-73757 https://reactome.org/PathwayBrowser/#/R-DDI-73757 Binding of RRN3 to RNA Polymerase I IEA Dictyostelium discoideum DDB_G0275759 R-DDI-73769 https://reactome.org/PathwayBrowser/#/R-DDI-73769 Loss of Rrn3 from RNA Polymerase I promoter escape complex IEA Dictyostelium discoideum DDB_G0275759 R-DDI-74986 https://reactome.org/PathwayBrowser/#/R-DDI-74986 Elongation of pre-rRNA transcript IEA Dictyostelium discoideum DDB_G0275765 R-DDI-481007 https://reactome.org/PathwayBrowser/#/R-DDI-481007 Exocytosis of platelet alpha granule contents IEA Dictyostelium discoideum DDB_G0275775 R-DDI-9908026 https://reactome.org/PathwayBrowser/#/R-DDI-9908026 Formation of the 19S regulatory particle precursor IEA Dictyostelium discoideum DDB_G0275775 R-DDI-9908178 https://reactome.org/PathwayBrowser/#/R-DDI-9908178 Formation of the 26S proteasome IEA Dictyostelium discoideum DDB_G0275787 R-DDI-5652005 https://reactome.org/PathwayBrowser/#/R-DDI-5652005 RAD18:UBE2B or RBX1:CUL4:DDB1:DTL ubiquitin ligase complex binds PCNA:POLD,POLE:RPA:RFC associated with damaged dsDNA IEA Dictyostelium discoideum DDB_G0275787 R-DDI-5652009 https://reactome.org/PathwayBrowser/#/R-DDI-5652009 RAD18:UBE2B or RBX1:CUL4:DDB1:DTL monoubiquitinates PCNA IEA Dictyostelium discoideum DDB_G0275787 R-DDI-8852130 https://reactome.org/PathwayBrowser/#/R-DDI-8852130 UBA1 conjugates ubiquitin to nuclear E2 enzymes IEA Dictyostelium discoideum DDB_G0275787 R-DDI-8943003 https://reactome.org/PathwayBrowser/#/R-DDI-8943003 SHPRH polyubiquitinates monoubiquitinated PCNA IEA Dictyostelium discoideum DDB_G0275787 R-DDI-8943007 https://reactome.org/PathwayBrowser/#/R-DDI-8943007 SHPRH binds monoUb-K164-PCNA, RAD6:RAD18, UBE2V2:Ub:UBE2N IEA Dictyostelium discoideum DDB_G0275787 R-DDI-983140 https://reactome.org/PathwayBrowser/#/R-DDI-983140 Transfer of Ub from E2 to substrate and release of E2 IEA Dictyostelium discoideum DDB_G0275787 R-DDI-983152 https://reactome.org/PathwayBrowser/#/R-DDI-983152 Transfer of ubiquitin from E1 to E2 IEA Dictyostelium discoideum DDB_G0275787 R-DDI-983156 https://reactome.org/PathwayBrowser/#/R-DDI-983156 Polyubiquitination of substrate IEA Dictyostelium discoideum DDB_G0275787 R-DDI-983157 https://reactome.org/PathwayBrowser/#/R-DDI-983157 Interaction of E3 with substrate and E2-Ub complex IEA Dictyostelium discoideum DDB_G0275809 R-DDI-5358510 https://reactome.org/PathwayBrowser/#/R-DDI-5358510 MSH2:MSH6 recruits MLH1:PMS2 to mismatch and interacts with PCNA IEA Dictyostelium discoideum DDB_G0275809 R-DDI-5358513 https://reactome.org/PathwayBrowser/#/R-DDI-5358513 MSH2:MSH3 binds insertion/deletion loop of 2 bases or more IEA Dictyostelium discoideum DDB_G0275809 R-DDI-5358518 https://reactome.org/PathwayBrowser/#/R-DDI-5358518 MLH1:PMS2 makes single strand incision near 1-2 base mismatch IEA Dictyostelium discoideum DDB_G0275809 R-DDI-5358525 https://reactome.org/PathwayBrowser/#/R-DDI-5358525 MSH2:MSH6 binds 1 base mismatch or 1-2 base insertion/deletion loop IEA Dictyostelium discoideum DDB_G0275809 R-DDI-5358597 https://reactome.org/PathwayBrowser/#/R-DDI-5358597 EXO1 interacts with MSH2:MSH6 (MutSalpha) and MLH1:PMS2 (MutLalpha) IEA Dictyostelium discoideum DDB_G0275809 R-DDI-5358912 https://reactome.org/PathwayBrowser/#/R-DDI-5358912 MSH2:MSH6 exchanges ADP for ATP IEA Dictyostelium discoideum DDB_G0275809 R-DDI-5444511 https://reactome.org/PathwayBrowser/#/R-DDI-5444511 Formation of MSH2:MSH3 Complex IEA Dictyostelium discoideum DDB_G0275809 R-DDI-5444516 https://reactome.org/PathwayBrowser/#/R-DDI-5444516 Formation of MSH2:MSH6 Complex IEA Dictyostelium discoideum DDB_G0275813 R-DDI-5336466 https://reactome.org/PathwayBrowser/#/R-DDI-5336466 MRS2 transports Mg2+ from cytosol to mitochondrial matrix IEA Dictyostelium discoideum DDB_G0275845 R-DDI-927832 https://reactome.org/PathwayBrowser/#/R-DDI-927832 UPF1 binds an mRNP with a termination codon preceding an Exon Junction Complex IEA Dictyostelium discoideum DDB_G0275845 R-DDI-927889 https://reactome.org/PathwayBrowser/#/R-DDI-927889 SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex) IEA Dictyostelium discoideum DDB_G0275851 R-DDI-5362412 https://reactome.org/PathwayBrowser/#/R-DDI-5362412 SYVN1 ubiquitinates Hh C-terminal fragments IEA Dictyostelium discoideum DDB_G0275863 R-DDI-2534087 https://reactome.org/PathwayBrowser/#/R-DDI-2534087 NMT1/2 transfer MYS to GNAT1 IEA Dictyostelium discoideum DDB_G0275865 R-DDI-1676149 https://reactome.org/PathwayBrowser/#/R-DDI-1676149 PI(3,4)P2 is dephosphorylated to PI4P by PTEN at the plasma membrane IEA Dictyostelium discoideum DDB_G0275865 R-DDI-1676204 https://reactome.org/PathwayBrowser/#/R-DDI-1676204 PI(3,4)P2 is dephosphorylated to PI4P by TPTE2 at the Golgi membrane IEA Dictyostelium discoideum DDB_G0275865 R-DDI-1855205 https://reactome.org/PathwayBrowser/#/R-DDI-1855205 I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by PTEN in the cytosol IEA Dictyostelium discoideum DDB_G0275865 R-DDI-199456 https://reactome.org/PathwayBrowser/#/R-DDI-199456 PTEN dephosphorylates PIP3 IEA Dictyostelium discoideum DDB_G0275865 R-DDI-5689950 https://reactome.org/PathwayBrowser/#/R-DDI-5689950 USP7 deubiquitinates TP53,MDM2,MDM4,FOXO4, PTEN IEA Dictyostelium discoideum DDB_G0275865 R-DDI-6807105 https://reactome.org/PathwayBrowser/#/R-DDI-6807105 Monoubiquitinated PTEN translocates to the nucleus IEA Dictyostelium discoideum DDB_G0275865 R-DDI-6807118 https://reactome.org/PathwayBrowser/#/R-DDI-6807118 USP7 deubiquitinates monoubiquitinated PTEN IEA Dictyostelium discoideum DDB_G0275865 R-DDI-6807126 https://reactome.org/PathwayBrowser/#/R-DDI-6807126 Deubiquitinated PTEN translocates to the cytosol IEA Dictyostelium discoideum DDB_G0275865 R-DDI-6807134 https://reactome.org/PathwayBrowser/#/R-DDI-6807134 NEDD4, WWP2, CHIP and XIAP polyubiquitinate PTEN IEA Dictyostelium discoideum DDB_G0275865 R-DDI-6807206 https://reactome.org/PathwayBrowser/#/R-DDI-6807206 USP13 and OTUD3 deubiquitinate PTEN IEA Dictyostelium discoideum DDB_G0275865 R-DDI-8850945 https://reactome.org/PathwayBrowser/#/R-DDI-8850945 Casein kinase II phosphorylates PTEN IEA Dictyostelium discoideum DDB_G0275865 R-DDI-8850992 https://reactome.org/PathwayBrowser/#/R-DDI-8850992 Proteasome degrades polyubiquitinated PTEN IEA Dictyostelium discoideum DDB_G0275865 R-DDI-8873946 https://reactome.org/PathwayBrowser/#/R-DDI-8873946 OTUD3 deubiquitinates PTEN IEA Dictyostelium discoideum DDB_G0275865 R-DDI-8948775 https://reactome.org/PathwayBrowser/#/R-DDI-8948775 MKRN1 polyubiquitinates PTEN IEA Dictyostelium discoideum DDB_G0275871 R-DDI-939763 https://reactome.org/PathwayBrowser/#/R-DDI-939763 P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane IEA Dictyostelium discoideum DDB_G0275871 R-DDI-947591 https://reactome.org/PathwayBrowser/#/R-DDI-947591 P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane IEA Dictyostelium discoideum DDB_G0275881 R-DDI-156823 https://reactome.org/PathwayBrowser/#/R-DDI-156823 Association of phospho-L13a with GAIT element of Ceruloplasmin mRNA IEA Dictyostelium discoideum DDB_G0275881 R-DDI-156826 https://reactome.org/PathwayBrowser/#/R-DDI-156826 Dissociation of L13a from the 60s ribosomal subunit IEA Dictyostelium discoideum DDB_G0275881 R-DDI-1799332 https://reactome.org/PathwayBrowser/#/R-DDI-1799332 Nascent polypeptide:mRNA:ribosome complex binds signal recognition particle (SRP) IEA Dictyostelium discoideum DDB_G0275881 R-DDI-72671 https://reactome.org/PathwayBrowser/#/R-DDI-72671 eIF5B:GTP is hydrolyzed and released IEA Dictyostelium discoideum DDB_G0275881 R-DDI-72672 https://reactome.org/PathwayBrowser/#/R-DDI-72672 The 60S subunit joins the translation initiation complex IEA Dictyostelium discoideum DDB_G0275881 R-DDI-72673 https://reactome.org/PathwayBrowser/#/R-DDI-72673 Release of 40S and 60S subunits from the 80S ribosome IEA Dictyostelium discoideum DDB_G0275881 R-DDI-927789 https://reactome.org/PathwayBrowser/#/R-DDI-927789 Formation of UPF1:eRF3 complex on mRNA with a premature termination codon and no Exon Junction Complex IEA Dictyostelium discoideum DDB_G0275881 R-DDI-927832 https://reactome.org/PathwayBrowser/#/R-DDI-927832 UPF1 binds an mRNP with a termination codon preceding an Exon Junction Complex IEA Dictyostelium discoideum DDB_G0275881 R-DDI-927889 https://reactome.org/PathwayBrowser/#/R-DDI-927889 SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex) IEA Dictyostelium discoideum DDB_G0275895 R-DDI-9866217 https://reactome.org/PathwayBrowser/#/R-DDI-9866217 HCCS inserts heme into cytochrome c IEA Dictyostelium discoideum DDB_G0275917 R-DDI-6798739 https://reactome.org/PathwayBrowser/#/R-DDI-6798739 Exocytosis of azurophil granule membrane proteins IEA Dictyostelium discoideum DDB_G0275917 R-DDI-8853710 https://reactome.org/PathwayBrowser/#/R-DDI-8853710 MANBA hydrolyses GlcNAc:Man IEA Dictyostelium discoideum DDB_G0275925 R-DDI-8952638 https://reactome.org/PathwayBrowser/#/R-DDI-8952638 AcM-UBE2M transfers NEDD8 to CRL4 E3 ubiquitin ligase complex IEA Dictyostelium discoideum DDB_G0275925 R-DDI-8952639 https://reactome.org/PathwayBrowser/#/R-DDI-8952639 NEDD8:AcM-UBE2M binds CRL4 E3 ubiquitin ligase complex IEA Dictyostelium discoideum DDB_G0275925 R-DDI-8955245 https://reactome.org/PathwayBrowser/#/R-DDI-8955245 CAND1 binds CRL4 E3 ubiquitin ligase in the nucleus IEA Dictyostelium discoideum DDB_G0275925 R-DDI-8955285 https://reactome.org/PathwayBrowser/#/R-DDI-8955285 COMMDs displace CAND1 from CRL4 E3 ubiquitin ligase complex IEA Dictyostelium discoideum DDB_G0275925 R-DDI-8956045 https://reactome.org/PathwayBrowser/#/R-DDI-8956045 COP9 signalosome deneddylates nuclear CRL4 E3 ubiquitin ligase complex IEA Dictyostelium discoideum DDB_G0275929 R-DDI-2466068 https://reactome.org/PathwayBrowser/#/R-DDI-2466068 Phosphorylation of cohesin by PLK1 at chromosomal arms IEA Dictyostelium discoideum DDB_G0275929 R-DDI-2468039 https://reactome.org/PathwayBrowser/#/R-DDI-2468039 Acetylation of SMC3 subunit of chromosomal arm associated cohesin by ESCO1 or ESCO2 IEA Dictyostelium discoideum DDB_G0275929 R-DDI-2470935 https://reactome.org/PathwayBrowser/#/R-DDI-2470935 Cohesin binding to decondensed chromatin is facilitated by NIPBL:MAU2 IEA Dictyostelium discoideum DDB_G0275929 R-DDI-2473152 https://reactome.org/PathwayBrowser/#/R-DDI-2473152 Acetylation of SMC3 subunit of centromeric chromatin associated cohesin by ESCO1 or ESCO2 IEA Dictyostelium discoideum DDB_G0275929 R-DDI-2545253 https://reactome.org/PathwayBrowser/#/R-DDI-2545253 Deacetylation of cohesin IEA Dictyostelium discoideum DDB_G0275931 R-DDI-2586748 https://reactome.org/PathwayBrowser/#/R-DDI-2586748 GUCA binds Ca2+ to form GUCA:Ca2+ IEA Dictyostelium discoideum DDB_G0275931 R-DDI-74885 https://reactome.org/PathwayBrowser/#/R-DDI-74885 GUCYs converts GTP to cGMP IEA Dictyostelium discoideum DDB_G0275939 R-DDI-420818 https://reactome.org/PathwayBrowser/#/R-DDI-420818 MBTPS2 (S2P) cleaves ATF6 (ATF6-alpha) IEA Dictyostelium discoideum DDB_G0275939 R-DDI-8874122 https://reactome.org/PathwayBrowser/#/R-DDI-8874122 MBTPS2 (S2P) cleaves ATF6B (ATF6-beta) IEA Dictyostelium discoideum DDB_G0275953 R-DDI-8936442 https://reactome.org/PathwayBrowser/#/R-DDI-8936442 MARC1,MARC2 reduce N-hydroxylated compounds IEA Dictyostelium discoideum DDB_G0275969 R-DDI-2214351 https://reactome.org/PathwayBrowser/#/R-DDI-2214351 PLK1 phosphorylates GORASP1 IEA Dictyostelium discoideum DDB_G0275969 R-DDI-5694409 https://reactome.org/PathwayBrowser/#/R-DDI-5694409 Nucleotide exchange on RAB1 IEA Dictyostelium discoideum DDB_G0275969 R-DDI-5694439 https://reactome.org/PathwayBrowser/#/R-DDI-5694439 COPII coat binds TRAPPCII and RAB1:GDP IEA Dictyostelium discoideum DDB_G0275969 R-DDI-5694441 https://reactome.org/PathwayBrowser/#/R-DDI-5694441 CSNK1D phosphorylates SEC23 IEA Dictyostelium discoideum DDB_G0275969 R-DDI-6807864 https://reactome.org/PathwayBrowser/#/R-DDI-6807864 RAB1:GTP recruits GBF1 to the ERGIC IEA Dictyostelium discoideum DDB_G0275969 R-DDI-6807866 https://reactome.org/PathwayBrowser/#/R-DDI-6807866 GBF1 recruits ARF:GDP to the ERGIC IEA Dictyostelium discoideum DDB_G0275969 R-DDI-6807868 https://reactome.org/PathwayBrowser/#/R-DDI-6807868 GBF1 stimulates ARF nucleotide exchange IEA Dictyostelium discoideum DDB_G0275969 R-DDI-6807872 https://reactome.org/PathwayBrowser/#/R-DDI-6807872 Active ARF recruits coatomer IEA Dictyostelium discoideum DDB_G0275969 R-DDI-6807875 https://reactome.org/PathwayBrowser/#/R-DDI-6807875 ARFGAP, cargo, v-SNAREs and p24 proteins bind nascent COPI complex IEA Dictyostelium discoideum DDB_G0275969 R-DDI-6807877 https://reactome.org/PathwayBrowser/#/R-DDI-6807877 ARFGAPs stimulate ARF GTPase activity IEA Dictyostelium discoideum DDB_G0275969 R-DDI-6809003 https://reactome.org/PathwayBrowser/#/R-DDI-6809003 ERGIC-to-Golgi vesicles bind dynein:dynactin IEA Dictyostelium discoideum DDB_G0275969 R-DDI-6809011 https://reactome.org/PathwayBrowser/#/R-DDI-6809011 cis-Golgi t-SNAREs bind YKT6 on tethered vesicle IEA Dictyostelium discoideum DDB_G0275969 R-DDI-6811411 https://reactome.org/PathwayBrowser/#/R-DDI-6811411 GBF1 recruits ARF:GDP to the Golgi IEA Dictyostelium discoideum DDB_G0275969 R-DDI-6811412 https://reactome.org/PathwayBrowser/#/R-DDI-6811412 Active ARF recruits coatomer to the Golgi IEA Dictyostelium discoideum DDB_G0275969 R-DDI-6811414 https://reactome.org/PathwayBrowser/#/R-DDI-6811414 GBF1 stimulates nucleotide exchange on ARF IEA Dictyostelium discoideum DDB_G0275969 R-DDI-6811415 https://reactome.org/PathwayBrowser/#/R-DDI-6811415 RAB:GTP recruits GBF1 to the Golgi membrane IEA Dictyostelium discoideum DDB_G0275969 R-DDI-6811417 https://reactome.org/PathwayBrowser/#/R-DDI-6811417 ARFGAP, cargo, vSNARES and p24 proteins bind COPI vesicles at Golgi IEA Dictyostelium discoideum DDB_G0275969 R-DDI-6811418 https://reactome.org/PathwayBrowser/#/R-DDI-6811418 ARFGAPs stimulate ARF GTPase activity at the Golgi membrane IEA Dictyostelium discoideum DDB_G0275969 R-DDI-6811427 https://reactome.org/PathwayBrowser/#/R-DDI-6811427 COPI vesicle uncoating at the ER IEA Dictyostelium discoideum DDB_G0275969 R-DDI-6814831 https://reactome.org/PathwayBrowser/#/R-DDI-6814831 TBC1D20 binds RAB1:GTP IEA Dictyostelium discoideum DDB_G0275969 R-DDI-6814833 https://reactome.org/PathwayBrowser/#/R-DDI-6814833 TBC1D20 stimulates GTPase activity of RAB1, resulting in hydrolysis of GTP IEA Dictyostelium discoideum DDB_G0275969 R-DDI-8847534 https://reactome.org/PathwayBrowser/#/R-DDI-8847534 RAB43 hydrolyses GTP IEA Dictyostelium discoideum DDB_G0275969 R-DDI-8847537 https://reactome.org/PathwayBrowser/#/R-DDI-8847537 RAB43:GTP binds USP8NL IEA Dictyostelium discoideum DDB_G0275969 R-DDI-8870466 https://reactome.org/PathwayBrowser/#/R-DDI-8870466 RGGT:CHM binds RABs IEA Dictyostelium discoideum DDB_G0275969 R-DDI-8870469 https://reactome.org/PathwayBrowser/#/R-DDI-8870469 RGGT geranylgeranylates RAB proteins IEA Dictyostelium discoideum DDB_G0275969 R-DDI-8877475 https://reactome.org/PathwayBrowser/#/R-DDI-8877475 TRAPPC complexes exchange GTP for GDP on RAB1 IEA Dictyostelium discoideum DDB_G0275983 R-DDI-68688 https://reactome.org/PathwayBrowser/#/R-DDI-68688 CDC6 association with ORC(1-6) at replication origins IEA Dictyostelium discoideum DDB_G0275983 R-DDI-68914 https://reactome.org/PathwayBrowser/#/R-DDI-68914 DNA polymerase alpha:primase binds at the origin IEA Dictyostelium discoideum DDB_G0275983 R-DDI-68917 https://reactome.org/PathwayBrowser/#/R-DDI-68917 Cdc45 associates with the pre-replicative complex at the origin IEA Dictyostelium discoideum DDB_G0275983 R-DDI-68960 https://reactome.org/PathwayBrowser/#/R-DDI-68960 DNA polymerase epsilon binds at the origin IEA Dictyostelium discoideum DDB_G0275983 R-DDI-69006 https://reactome.org/PathwayBrowser/#/R-DDI-69006 Phosphorylated Cdc6 is exported from the nucleus IEA Dictyostelium discoideum DDB_G0275983 R-DDI-69015 https://reactome.org/PathwayBrowser/#/R-DDI-69015 Cytoplasmic phosphorylated Cdc6 is ubiquitinated by the anaphase-promoting complex IEA Dictyostelium discoideum DDB_G0275983 R-DDI-69016 https://reactome.org/PathwayBrowser/#/R-DDI-69016 Ubiquitinated Cdc6 is degraded by the proteasome IEA Dictyostelium discoideum DDB_G0275983 R-DDI-9749215 https://reactome.org/PathwayBrowser/#/R-DDI-9749215 MCM8 binds CDC6 IEA Dictyostelium discoideum DDB_G0276019 R-DDI-205039 https://reactome.org/PathwayBrowser/#/R-DDI-205039 p75NTR indirectly activates RAC and Cdc42 via a guanyl-nucleotide exchange factor IEA Dictyostelium discoideum DDB_G0276019 R-DDI-9013143 https://reactome.org/PathwayBrowser/#/R-DDI-9013143 RAC1 GEFs activate RAC1 IEA Dictyostelium discoideum DDB_G0276019 R-DDI-9013159 https://reactome.org/PathwayBrowser/#/R-DDI-9013159 CDC42 GEFs activate CDC42 IEA Dictyostelium discoideum DDB_G0276025 R-DDI-9793472 https://reactome.org/PathwayBrowser/#/R-DDI-9793472 RIPK3 binds p-S9-PRKN IEA Dictyostelium discoideum DDB_G0276025 R-DDI-9793485 https://reactome.org/PathwayBrowser/#/R-DDI-9793485 PRKN polyubiquitinates RIPK3 IEA Dictyostelium discoideum DDB_G0276029 R-DDI-6798044 https://reactome.org/PathwayBrowser/#/R-DDI-6798044 BTG2 binds CCR4-NOT complex IEA Dictyostelium discoideum DDB_G0276057 R-DDI-9018766 https://reactome.org/PathwayBrowser/#/R-DDI-9018766 RHOU binds effectors at the plasma membrane IEA Dictyostelium discoideum DDB_G0276057 R-DDI-9018778 https://reactome.org/PathwayBrowser/#/R-DDI-9018778 RHOBTB1 binds interacting proteins at the endosome membrane IEA Dictyostelium discoideum DDB_G0276057 R-DDI-9018787 https://reactome.org/PathwayBrowser/#/R-DDI-9018787 RHOBTB2 binds interacting proteins at the endosome membrane IEA Dictyostelium discoideum DDB_G0276057 R-DDI-9018794 https://reactome.org/PathwayBrowser/#/R-DDI-9018794 RHOV binds effectors at the plasma membrane IEA Dictyostelium discoideum DDB_G0276077 R-DDI-5668932 https://reactome.org/PathwayBrowser/#/R-DDI-5668932 PAK2 phosphorylates myosin regulatory light chain (MRLC) IEA Dictyostelium discoideum DDB_G0276101 R-DDI-2466068 https://reactome.org/PathwayBrowser/#/R-DDI-2466068 Phosphorylation of cohesin by PLK1 at chromosomal arms IEA Dictyostelium discoideum DDB_G0276101 R-DDI-2468039 https://reactome.org/PathwayBrowser/#/R-DDI-2468039 Acetylation of SMC3 subunit of chromosomal arm associated cohesin by ESCO1 or ESCO2 IEA Dictyostelium discoideum DDB_G0276101 R-DDI-2470935 https://reactome.org/PathwayBrowser/#/R-DDI-2470935 Cohesin binding to decondensed chromatin is facilitated by NIPBL:MAU2 IEA Dictyostelium discoideum DDB_G0276101 R-DDI-2473152 https://reactome.org/PathwayBrowser/#/R-DDI-2473152 Acetylation of SMC3 subunit of centromeric chromatin associated cohesin by ESCO1 or ESCO2 IEA Dictyostelium discoideum DDB_G0276101 R-DDI-2545253 https://reactome.org/PathwayBrowser/#/R-DDI-2545253 Deacetylation of cohesin IEA Dictyostelium discoideum DDB_G0276101 R-DDI-3108212 https://reactome.org/PathwayBrowser/#/R-DDI-3108212 SMC5-SMC6 Complex SUMOylates Cohesin with SUMO1 IEA Dictyostelium discoideum DDB_G0276115 R-DDI-5358484 https://reactome.org/PathwayBrowser/#/R-DDI-5358484 DPH5 transfers four methyl groups from AdoMet to aminocarboxypropyl EEF2 IEA Dictyostelium discoideum DDB_G0276119 R-DDI-8854255 https://reactome.org/PathwayBrowser/#/R-DDI-8854255 TBC1D2A accelerates GTP hydrolysis by RAB7 IEA Dictyostelium discoideum DDB_G0276137 R-DDI-6791227 https://reactome.org/PathwayBrowser/#/R-DDI-6791227 47S pre-rRNA is nucleolytically processed at A' (01,A1), site A0, and site 02 (site 6) to yield 45S pre-rRNA IEA Dictyostelium discoideum DDB_G0276153 R-DDI-5694423 https://reactome.org/PathwayBrowser/#/R-DDI-5694423 NSF and SNAPs bind cis-SNARE complex IEA Dictyostelium discoideum DDB_G0276153 R-DDI-5694425 https://reactome.org/PathwayBrowser/#/R-DDI-5694425 NSF ATPase activity dissociates cis-SNARE IEA Dictyostelium discoideum DDB_G0276153 R-DDI-6809014 https://reactome.org/PathwayBrowser/#/R-DDI-6809014 cis-Golgi cis-SNARE binds NSF and SNAPs IEA Dictyostelium discoideum DDB_G0276153 R-DDI-6809015 https://reactome.org/PathwayBrowser/#/R-DDI-6809015 NSF ATPase activity dissociates cis-SNARE at cis-Golgi IEA Dictyostelium discoideum DDB_G0276153 R-DDI-6811422 https://reactome.org/PathwayBrowser/#/R-DDI-6811422 NSF ATPase activity dissociates cis-SNARE at the ER IEA Dictyostelium discoideum DDB_G0276153 R-DDI-6811425 https://reactome.org/PathwayBrowser/#/R-DDI-6811425 NSF and SNAPs bind cis-SNARE at the ER membrane IEA Dictyostelium discoideum DDB_G0276153 R-DDI-6814676 https://reactome.org/PathwayBrowser/#/R-DDI-6814676 SNAPs and NSF hexamer bind cis-SNARE at the TGN IEA Dictyostelium discoideum DDB_G0276153 R-DDI-6814678 https://reactome.org/PathwayBrowser/#/R-DDI-6814678 ATP hydrolysis by NSF disassembles the cis-SNARE at the TGN IEA Dictyostelium discoideum DDB_G0276153 R-DDI-6814684 https://reactome.org/PathwayBrowser/#/R-DDI-6814684 cis-SNARE binds SNAPs and NSF hexamer at the TGN IEA Dictyostelium discoideum DDB_G0276153 R-DDI-8847637 https://reactome.org/PathwayBrowser/#/R-DDI-8847637 NSF and SNAPs bind the cis-SNARE at the Golgi IEA Dictyostelium discoideum DDB_G0276153 R-DDI-8847638 https://reactome.org/PathwayBrowser/#/R-DDI-8847638 ATP hydrolysis by NSF disassembles the cis-SNARE at the Golgi membrane IEA Dictyostelium discoideum DDB_G0276169 R-DDI-9603775 https://reactome.org/PathwayBrowser/#/R-DDI-9603775 PEX3:PEX19:class I PMP dissociates IEA Dictyostelium discoideum DDB_G0276169 R-DDI-9603784 https://reactome.org/PathwayBrowser/#/R-DDI-9603784 PEX19:class I PMP binds PEX3 IEA Dictyostelium discoideum DDB_G0276169 R-DDI-9603804 https://reactome.org/PathwayBrowser/#/R-DDI-9603804 PEX19 binds class I peroxisomal membrane proteins IEA Dictyostelium discoideum DDB_G0276187 R-DDI-9793472 https://reactome.org/PathwayBrowser/#/R-DDI-9793472 RIPK3 binds p-S9-PRKN IEA Dictyostelium discoideum DDB_G0276187 R-DDI-9793485 https://reactome.org/PathwayBrowser/#/R-DDI-9793485 PRKN polyubiquitinates RIPK3 IEA Dictyostelium discoideum DDB_G0276227 R-DDI-6798743 https://reactome.org/PathwayBrowser/#/R-DDI-6798743 Exocytosis of secretory granule membrane proteins IEA Dictyostelium discoideum DDB_G0276227 R-DDI-8854329 https://reactome.org/PathwayBrowser/#/R-DDI-8854329 TBC1D15 accelerates GTP hydrolysis by RAB7 IEA Dictyostelium discoideum DDB_G0276227 R-DDI-8870466 https://reactome.org/PathwayBrowser/#/R-DDI-8870466 RGGT:CHM binds RABs IEA Dictyostelium discoideum DDB_G0276227 R-DDI-8870469 https://reactome.org/PathwayBrowser/#/R-DDI-8870469 RGGT geranylgeranylates RAB proteins IEA Dictyostelium discoideum DDB_G0276227 R-DDI-8876191 https://reactome.org/PathwayBrowser/#/R-DDI-8876191 RAB9 GEFs exchange GTP for GDP on RAB9 IEA Dictyostelium discoideum DDB_G0276227 R-DDI-8877451 https://reactome.org/PathwayBrowser/#/R-DDI-8877451 MON1:CCZ1 exchanges GTP for GDP on RAB7 IEA Dictyostelium discoideum DDB_G0276227 R-DDI-9706390 https://reactome.org/PathwayBrowser/#/R-DDI-9706390 RHOBTB3 binds interacting proteins at trans-Golgi network IEA Dictyostelium discoideum DDB_G0276233 R-DDI-391266 https://reactome.org/PathwayBrowser/#/R-DDI-391266 Association of CCT/TriC with sphingosine kinase 1 IEA Dictyostelium discoideum DDB_G0276233 R-DDI-6798748 https://reactome.org/PathwayBrowser/#/R-DDI-6798748 Exocytosis of secretory granule lumen proteins IEA Dictyostelium discoideum DDB_G0276233 R-DDI-6798751 https://reactome.org/PathwayBrowser/#/R-DDI-6798751 Exocytosis of azurophil granule lumen proteins IEA Dictyostelium discoideum DDB_G0276233 R-DDI-6800434 https://reactome.org/PathwayBrowser/#/R-DDI-6800434 Exocytosis of ficolin-rich granule lumen proteins IEA Dictyostelium discoideum DDB_G0276233 R-DDI-6814119 https://reactome.org/PathwayBrowser/#/R-DDI-6814119 TRiC/CCT binds unfolded G-protein beta subunit IEA Dictyostelium discoideum DDB_G0276233 R-DDI-6814120 https://reactome.org/PathwayBrowser/#/R-DDI-6814120 ATP hydrolysis promotes folding of G-protein beta by TRiC/CCT IEA Dictyostelium discoideum DDB_G0276233 R-DDI-6814124 https://reactome.org/PathwayBrowser/#/R-DDI-6814124 ATP binds G-protein beta associated TRiC/CCT IEA Dictyostelium discoideum DDB_G0276237 R-DDI-5205798 https://reactome.org/PathwayBrowser/#/R-DDI-5205798 PRMT1,PRMT6 methylate arginine-4 of histone H4 IEA Dictyostelium discoideum DDB_G0276237 R-DDI-5205867 https://reactome.org/PathwayBrowser/#/R-DDI-5205867 PRMT1 methylates arginine-12 of histone H2A (H2AR11) IEA Dictyostelium discoideum DDB_G0276237 R-DDI-5661126 https://reactome.org/PathwayBrowser/#/R-DDI-5661126 PRMT1,PRMT6 methylate methyl-lysine-4 of histone H4 IEA Dictyostelium discoideum DDB_G0276237 R-DDI-8879123 https://reactome.org/PathwayBrowser/#/R-DDI-8879123 PRMT3 transfers 3xCH3 from 3xAdoMet to RPS2 IEA Dictyostelium discoideum DDB_G0276237 R-DDI-9023860 https://reactome.org/PathwayBrowser/#/R-DDI-9023860 Histone acetyltransferases are recruited to the TFF1 gene IEA Dictyostelium discoideum DDB_G0276251 R-DDI-162742 https://reactome.org/PathwayBrowser/#/R-DDI-162742 (ethanolamineP) mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI -> (ethanolamineP) mannose (a1-2) (ethanolamineP) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI IEA Dictyostelium discoideum DDB_G0276253 R-DDI-70262 https://reactome.org/PathwayBrowser/#/R-DDI-70262 Fructose 2,6-bisphosphate is hydrolyzed to form fructose-6-phosphate and orthophosphate IEA Dictyostelium discoideum DDB_G0276253 R-DDI-71802 https://reactome.org/PathwayBrowser/#/R-DDI-71802 D-fructose 6-phosphate + ATP => D-fructose 2,6-bisphosphate + ADP IEA Dictyostelium discoideum DDB_G0276267 R-DDI-111879 https://reactome.org/PathwayBrowser/#/R-DDI-111879 PIP2 hydrolysis IEA Dictyostelium discoideum DDB_G0276267 R-DDI-112037 https://reactome.org/PathwayBrowser/#/R-DDI-112037 Inactivation of PLC beta IEA Dictyostelium discoideum DDB_G0276267 R-DDI-114688 https://reactome.org/PathwayBrowser/#/R-DDI-114688 PLC-beta hydrolyses PIP2 to DAG and IP3 IEA Dictyostelium discoideum DDB_G0276267 R-DDI-167415 https://reactome.org/PathwayBrowser/#/R-DDI-167415 G-protein alpha subunit is inactivated IEA Dictyostelium discoideum DDB_G0276267 R-DDI-170666 https://reactome.org/PathwayBrowser/#/R-DDI-170666 Adenylate cyclase increases the GTPase activity of G alpha-olf IEA Dictyostelium discoideum DDB_G0276267 R-DDI-170671 https://reactome.org/PathwayBrowser/#/R-DDI-170671 G alpha-olf:GTP binds to Gi alpha1:GTP:adenylate cyclase complex IEA Dictyostelium discoideum DDB_G0276267 R-DDI-170672 https://reactome.org/PathwayBrowser/#/R-DDI-170672 Galpha-olf:GTP binds to adenylate cyclase and activates it IEA Dictyostelium discoideum DDB_G0276267 R-DDI-170674 https://reactome.org/PathwayBrowser/#/R-DDI-170674 Dissociation of the Gi alpha:G olf complex IEA Dictyostelium discoideum DDB_G0276267 R-DDI-170676 https://reactome.org/PathwayBrowser/#/R-DDI-170676 Adenylate cyclase converts ATP into cyclic AMP IEA Dictyostelium discoideum DDB_G0276267 R-DDI-170677 https://reactome.org/PathwayBrowser/#/R-DDI-170677 The G alpha-olf:GDP:Adenylate cyclase complex dissociates IEA Dictyostelium discoideum DDB_G0276267 R-DDI-170685 https://reactome.org/PathwayBrowser/#/R-DDI-170685 Adenylaye cyclase increases the GTPase activity of G alpha-olf IEA Dictyostelium discoideum DDB_G0276267 R-DDI-170686 https://reactome.org/PathwayBrowser/#/R-DDI-170686 Adenylate cyclase increases the GTPase activity of Gi alpha IEA Dictyostelium discoideum DDB_G0276267 R-DDI-399998 https://reactome.org/PathwayBrowser/#/R-DDI-399998 Activated Phospholipase C beta-1 hydrolyzes 1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate IEA Dictyostelium discoideum DDB_G0276267 R-DDI-418574 https://reactome.org/PathwayBrowser/#/R-DDI-418574 G alpha (12/13) auto-inactivates by hydrolysing GTP to GDP IEA Dictyostelium discoideum DDB_G0276267 R-DDI-418582 https://reactome.org/PathwayBrowser/#/R-DDI-418582 G alpha (q) auto-inactivates by hydrolysing GTP to GDP IEA Dictyostelium discoideum DDB_G0276267 R-DDI-428941 https://reactome.org/PathwayBrowser/#/R-DDI-428941 P2Y purinoceptor 1 activates MAP kinase p38 alpha IEA Dictyostelium discoideum DDB_G0276267 R-DDI-8982017 https://reactome.org/PathwayBrowser/#/R-DDI-8982017 Active G alpha (q) binds RGS proteins IEA Dictyostelium discoideum DDB_G0276267 R-DDI-8982025 https://reactome.org/PathwayBrowser/#/R-DDI-8982025 G alpha (q) in G (q):RGS complex is inactivated IEA Dictyostelium discoideum DDB_G0276267 R-DDI-8982026 https://reactome.org/PathwayBrowser/#/R-DDI-8982026 G alpha (q):RGS dissociates to inactive G alpha (q) IEA Dictyostelium discoideum DDB_G0276267 R-DDI-9013143 https://reactome.org/PathwayBrowser/#/R-DDI-9013143 RAC1 GEFs activate RAC1 IEA Dictyostelium discoideum DDB_G0276267 R-DDI-9013159 https://reactome.org/PathwayBrowser/#/R-DDI-9013159 CDC42 GEFs activate CDC42 IEA Dictyostelium discoideum DDB_G0276267 R-DDI-9860796 https://reactome.org/PathwayBrowser/#/R-DDI-9860796 Phosphorylation of PDPK1 on serine-241 IEA Dictyostelium discoideum DDB_G0276267 R-DDI-9860800 https://reactome.org/PathwayBrowser/#/R-DDI-9860800 mTORC2 phosphorylates AKT1 on serine-473 IEA Dictyostelium discoideum DDB_G0276273 R-DDI-2172678 https://reactome.org/PathwayBrowser/#/R-DDI-2172678 PHF8 demethylates histone H4K20me1 IEA Dictyostelium discoideum DDB_G0276273 R-DDI-2288097 https://reactome.org/PathwayBrowser/#/R-DDI-2288097 Condensin II complex binds H4K20me1-containing nucleosomes IEA Dictyostelium discoideum DDB_G0276273 R-DDI-2294580 https://reactome.org/PathwayBrowser/#/R-DDI-2294580 PLK1 hyperphosphorylates Condensin II complex IEA Dictyostelium discoideum DDB_G0276273 R-DDI-2294590 https://reactome.org/PathwayBrowser/#/R-DDI-2294590 PLK1 binds phosphorylated condensin II complex IEA Dictyostelium discoideum DDB_G0276273 R-DDI-3222593 https://reactome.org/PathwayBrowser/#/R-DDI-3222593 KDM6B demethylates H3K27me3 on p16INK4A promoter IEA Dictyostelium discoideum DDB_G0276273 R-DDI-3769447 https://reactome.org/PathwayBrowser/#/R-DDI-3769447 HDAC1:2-containing complex deacetylate histones IEA Dictyostelium discoideum DDB_G0276273 R-DDI-3782637 https://reactome.org/PathwayBrowser/#/R-DDI-3782637 HDAC8 deacetylates histones IEA Dictyostelium discoideum DDB_G0276273 R-DDI-3782655 https://reactome.org/PathwayBrowser/#/R-DDI-3782655 HDAC10 deacetylates histone IEA Dictyostelium discoideum DDB_G0276273 R-DDI-427514 https://reactome.org/PathwayBrowser/#/R-DDI-427514 eNoSC deacetylates histone H3 IEA Dictyostelium discoideum DDB_G0276273 R-DDI-427527 https://reactome.org/PathwayBrowser/#/R-DDI-427527 eNoSC dimethylates histone H3 at lysine-9 IEA Dictyostelium discoideum DDB_G0276273 R-DDI-5625784 https://reactome.org/PathwayBrowser/#/R-DDI-5625784 PKN1 phosphorylates histone 3 of nucleosomes associate with KLK2 and KLK3 promoters IEA Dictyostelium discoideum DDB_G0276273 R-DDI-5682588 https://reactome.org/PathwayBrowser/#/R-DDI-5682588 RNF8 binds phosphorylated MDC1 at DNA DSBs IEA Dictyostelium discoideum DDB_G0276273 R-DDI-5682965 https://reactome.org/PathwayBrowser/#/R-DDI-5682965 WHSC1 dimethylates histone H4 on lysine K21 at DSBs IEA Dictyostelium discoideum DDB_G0276273 R-DDI-5682967 https://reactome.org/PathwayBrowser/#/R-DDI-5682967 WHSC1 binds DNA DSBs IEA Dictyostelium discoideum DDB_G0276273 R-DDI-5682983 https://reactome.org/PathwayBrowser/#/R-DDI-5682983 ATM phosphorylates WHSC1 IEA Dictyostelium discoideum DDB_G0276273 R-DDI-5683405 https://reactome.org/PathwayBrowser/#/R-DDI-5683405 PPP5C dephosphorylates TP53BP1 IEA Dictyostelium discoideum DDB_G0276273 R-DDI-5683425 https://reactome.org/PathwayBrowser/#/R-DDI-5683425 ATM phosphorylates TP53BP1 at DNA DSBs IEA Dictyostelium discoideum DDB_G0276273 R-DDI-5690080 https://reactome.org/PathwayBrowser/#/R-DDI-5690080 USP3,SAGA deubiquitinate Histone H2A,H2B IEA Dictyostelium discoideum DDB_G0276273 R-DDI-5693536 https://reactome.org/PathwayBrowser/#/R-DDI-5693536 ATM phosphorylates MDC1 IEA Dictyostelium discoideum DDB_G0276273 R-DDI-5693549 https://reactome.org/PathwayBrowser/#/R-DDI-5693549 ATM phosphorylates histone H2AFX on S139 at DNA DSBs IEA Dictyostelium discoideum DDB_G0276273 R-DDI-5693566 https://reactome.org/PathwayBrowser/#/R-DDI-5693566 TP53BP1 associates with H4K20Me2 at DNA DSBs IEA Dictyostelium discoideum DDB_G0276273 R-DDI-5693602 https://reactome.org/PathwayBrowser/#/R-DDI-5693602 ATM recognizes H2AFX-Nucleosomes IEA Dictyostelium discoideum DDB_G0276273 R-DDI-5696960 https://reactome.org/PathwayBrowser/#/R-DDI-5696960 USP49 deubiquitinates H2B IEA Dictyostelium discoideum DDB_G0276273 R-DDI-74986 https://reactome.org/PathwayBrowser/#/R-DDI-74986 Elongation of pre-rRNA transcript IEA Dictyostelium discoideum DDB_G0276273 R-DDI-9749197 https://reactome.org/PathwayBrowser/#/R-DDI-9749197 ORC1 binds to H4K20me2 IEA Dictyostelium discoideum DDB_G0276273 R-DDI-9843978 https://reactome.org/PathwayBrowser/#/R-DDI-9843978 CBX5 (HP-1alpha) binds TRIM28 (KAP1) in SUMO2-6K-TRIM28:KRAB-ZFP:retroelement chromatin IEA Dictyostelium discoideum DDB_G0276283 R-DDI-6791222 https://reactome.org/PathwayBrowser/#/R-DDI-6791222 21S pre-rRNA is nucleolytically processed at site E (site2a) to yield 18SE pre-rRNA IEA Dictyostelium discoideum DDB_G0276283 R-DDI-6791227 https://reactome.org/PathwayBrowser/#/R-DDI-6791227 47S pre-rRNA is nucleolytically processed at A' (01,A1), site A0, and site 02 (site 6) to yield 45S pre-rRNA IEA Dictyostelium discoideum DDB_G0276295 R-DDI-2214351 https://reactome.org/PathwayBrowser/#/R-DDI-2214351 PLK1 phosphorylates GORASP1 IEA Dictyostelium discoideum DDB_G0276295 R-DDI-5694409 https://reactome.org/PathwayBrowser/#/R-DDI-5694409 Nucleotide exchange on RAB1 IEA Dictyostelium discoideum DDB_G0276295 R-DDI-5694439 https://reactome.org/PathwayBrowser/#/R-DDI-5694439 COPII coat binds TRAPPCII and RAB1:GDP IEA Dictyostelium discoideum DDB_G0276295 R-DDI-5694441 https://reactome.org/PathwayBrowser/#/R-DDI-5694441 CSNK1D phosphorylates SEC23 IEA Dictyostelium discoideum DDB_G0276295 R-DDI-6807864 https://reactome.org/PathwayBrowser/#/R-DDI-6807864 RAB1:GTP recruits GBF1 to the ERGIC IEA Dictyostelium discoideum DDB_G0276295 R-DDI-6807866 https://reactome.org/PathwayBrowser/#/R-DDI-6807866 GBF1 recruits ARF:GDP to the ERGIC IEA Dictyostelium discoideum DDB_G0276295 R-DDI-6807868 https://reactome.org/PathwayBrowser/#/R-DDI-6807868 GBF1 stimulates ARF nucleotide exchange IEA Dictyostelium discoideum DDB_G0276295 R-DDI-6807872 https://reactome.org/PathwayBrowser/#/R-DDI-6807872 Active ARF recruits coatomer IEA Dictyostelium discoideum DDB_G0276295 R-DDI-6807875 https://reactome.org/PathwayBrowser/#/R-DDI-6807875 ARFGAP, cargo, v-SNAREs and p24 proteins bind nascent COPI complex IEA Dictyostelium discoideum DDB_G0276295 R-DDI-6807877 https://reactome.org/PathwayBrowser/#/R-DDI-6807877 ARFGAPs stimulate ARF GTPase activity IEA Dictyostelium discoideum DDB_G0276295 R-DDI-6809003 https://reactome.org/PathwayBrowser/#/R-DDI-6809003 ERGIC-to-Golgi vesicles bind dynein:dynactin IEA Dictyostelium discoideum DDB_G0276295 R-DDI-6809011 https://reactome.org/PathwayBrowser/#/R-DDI-6809011 cis-Golgi t-SNAREs bind YKT6 on tethered vesicle IEA Dictyostelium discoideum DDB_G0276295 R-DDI-6811411 https://reactome.org/PathwayBrowser/#/R-DDI-6811411 GBF1 recruits ARF:GDP to the Golgi IEA Dictyostelium discoideum DDB_G0276295 R-DDI-6811412 https://reactome.org/PathwayBrowser/#/R-DDI-6811412 Active ARF recruits coatomer to the Golgi IEA Dictyostelium discoideum DDB_G0276295 R-DDI-6811414 https://reactome.org/PathwayBrowser/#/R-DDI-6811414 GBF1 stimulates nucleotide exchange on ARF IEA Dictyostelium discoideum DDB_G0276295 R-DDI-6811415 https://reactome.org/PathwayBrowser/#/R-DDI-6811415 RAB:GTP recruits GBF1 to the Golgi membrane IEA Dictyostelium discoideum DDB_G0276295 R-DDI-6811417 https://reactome.org/PathwayBrowser/#/R-DDI-6811417 ARFGAP, cargo, vSNARES and p24 proteins bind COPI vesicles at Golgi IEA Dictyostelium discoideum DDB_G0276295 R-DDI-6811418 https://reactome.org/PathwayBrowser/#/R-DDI-6811418 ARFGAPs stimulate ARF GTPase activity at the Golgi membrane IEA Dictyostelium discoideum DDB_G0276295 R-DDI-6811427 https://reactome.org/PathwayBrowser/#/R-DDI-6811427 COPI vesicle uncoating at the ER IEA Dictyostelium discoideum DDB_G0276295 R-DDI-6814831 https://reactome.org/PathwayBrowser/#/R-DDI-6814831 TBC1D20 binds RAB1:GTP IEA Dictyostelium discoideum DDB_G0276295 R-DDI-6814833 https://reactome.org/PathwayBrowser/#/R-DDI-6814833 TBC1D20 stimulates GTPase activity of RAB1, resulting in hydrolysis of GTP IEA Dictyostelium discoideum DDB_G0276295 R-DDI-8847534 https://reactome.org/PathwayBrowser/#/R-DDI-8847534 RAB43 hydrolyses GTP IEA Dictyostelium discoideum DDB_G0276295 R-DDI-8847537 https://reactome.org/PathwayBrowser/#/R-DDI-8847537 RAB43:GTP binds USP8NL IEA Dictyostelium discoideum DDB_G0276295 R-DDI-8870466 https://reactome.org/PathwayBrowser/#/R-DDI-8870466 RGGT:CHM binds RABs IEA Dictyostelium discoideum DDB_G0276295 R-DDI-8870469 https://reactome.org/PathwayBrowser/#/R-DDI-8870469 RGGT geranylgeranylates RAB proteins IEA Dictyostelium discoideum DDB_G0276295 R-DDI-8877475 https://reactome.org/PathwayBrowser/#/R-DDI-8877475 TRAPPC complexes exchange GTP for GDP on RAB1 IEA Dictyostelium discoideum DDB_G0276317 R-DDI-482772 https://reactome.org/PathwayBrowser/#/R-DDI-482772 Release of platelet cytosolic components IEA Dictyostelium discoideum DDB_G0276335 R-DDI-73571 https://reactome.org/PathwayBrowser/#/R-DDI-73571 CAD hexamer dehydrates N-carb-L-Asp to (S)-DHO IEA Dictyostelium discoideum DDB_G0276335 R-DDI-73573 https://reactome.org/PathwayBrowser/#/R-DDI-73573 CAD hexamer transforms CAP to N-carb-L-Asp IEA Dictyostelium discoideum DDB_G0276335 R-DDI-73577 https://reactome.org/PathwayBrowser/#/R-DDI-73577 CAD hexamer transforms L-Gln to CAP IEA Dictyostelium discoideum DDB_G0276341 R-DDI-2993447 https://reactome.org/PathwayBrowser/#/R-DDI-2993447 HLCS biotinylates 6x(PCCA:PCCB) IEA Dictyostelium discoideum DDB_G0276341 R-DDI-3323111 https://reactome.org/PathwayBrowser/#/R-DDI-3323111 Cytoslic carboxylases translocate to mitochondrial matrix IEA Dictyostelium discoideum DDB_G0276341 R-DDI-71031 https://reactome.org/PathwayBrowser/#/R-DDI-71031 propionyl-CoA + CO2 + ATP <=> D-methylmalonyl-CoA + ADP + orthophosphate IEA Dictyostelium discoideum DDB_G0276341 R-DDI-9838081 https://reactome.org/PathwayBrowser/#/R-DDI-9838081 LONP1 degrades mitochondrial matrix proteins IEA Dictyostelium discoideum DDB_G0276341 R-DDI-9838093 https://reactome.org/PathwayBrowser/#/R-DDI-9838093 LONP1 binds mitochondrial matrix proteins IEA Dictyostelium discoideum DDB_G0276343 R-DDI-111879 https://reactome.org/PathwayBrowser/#/R-DDI-111879 PIP2 hydrolysis IEA Dictyostelium discoideum DDB_G0276343 R-DDI-112037 https://reactome.org/PathwayBrowser/#/R-DDI-112037 Inactivation of PLC beta IEA Dictyostelium discoideum DDB_G0276343 R-DDI-114688 https://reactome.org/PathwayBrowser/#/R-DDI-114688 PLC-beta hydrolyses PIP2 to DAG and IP3 IEA Dictyostelium discoideum DDB_G0276343 R-DDI-167415 https://reactome.org/PathwayBrowser/#/R-DDI-167415 G-protein alpha subunit is inactivated IEA Dictyostelium discoideum DDB_G0276343 R-DDI-170666 https://reactome.org/PathwayBrowser/#/R-DDI-170666 Adenylate cyclase increases the GTPase activity of G alpha-olf IEA Dictyostelium discoideum DDB_G0276343 R-DDI-170671 https://reactome.org/PathwayBrowser/#/R-DDI-170671 G alpha-olf:GTP binds to Gi alpha1:GTP:adenylate cyclase complex IEA Dictyostelium discoideum DDB_G0276343 R-DDI-170672 https://reactome.org/PathwayBrowser/#/R-DDI-170672 Galpha-olf:GTP binds to adenylate cyclase and activates it IEA Dictyostelium discoideum DDB_G0276343 R-DDI-170674 https://reactome.org/PathwayBrowser/#/R-DDI-170674 Dissociation of the Gi alpha:G olf complex IEA Dictyostelium discoideum DDB_G0276343 R-DDI-170676 https://reactome.org/PathwayBrowser/#/R-DDI-170676 Adenylate cyclase converts ATP into cyclic AMP IEA Dictyostelium discoideum DDB_G0276343 R-DDI-170677 https://reactome.org/PathwayBrowser/#/R-DDI-170677 The G alpha-olf:GDP:Adenylate cyclase complex dissociates IEA Dictyostelium discoideum DDB_G0276343 R-DDI-170685 https://reactome.org/PathwayBrowser/#/R-DDI-170685 Adenylaye cyclase increases the GTPase activity of G alpha-olf IEA Dictyostelium discoideum DDB_G0276343 R-DDI-170686 https://reactome.org/PathwayBrowser/#/R-DDI-170686 Adenylate cyclase increases the GTPase activity of Gi alpha IEA Dictyostelium discoideum DDB_G0276343 R-DDI-399998 https://reactome.org/PathwayBrowser/#/R-DDI-399998 Activated Phospholipase C beta-1 hydrolyzes 1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate IEA Dictyostelium discoideum DDB_G0276343 R-DDI-418574 https://reactome.org/PathwayBrowser/#/R-DDI-418574 G alpha (12/13) auto-inactivates by hydrolysing GTP to GDP IEA Dictyostelium discoideum DDB_G0276343 R-DDI-418582 https://reactome.org/PathwayBrowser/#/R-DDI-418582 G alpha (q) auto-inactivates by hydrolysing GTP to GDP IEA Dictyostelium discoideum DDB_G0276343 R-DDI-428941 https://reactome.org/PathwayBrowser/#/R-DDI-428941 P2Y purinoceptor 1 activates MAP kinase p38 alpha IEA Dictyostelium discoideum DDB_G0276343 R-DDI-8982017 https://reactome.org/PathwayBrowser/#/R-DDI-8982017 Active G alpha (q) binds RGS proteins IEA Dictyostelium discoideum DDB_G0276343 R-DDI-8982025 https://reactome.org/PathwayBrowser/#/R-DDI-8982025 G alpha (q) in G (q):RGS complex is inactivated IEA Dictyostelium discoideum DDB_G0276343 R-DDI-8982026 https://reactome.org/PathwayBrowser/#/R-DDI-8982026 G alpha (q):RGS dissociates to inactive G alpha (q) IEA Dictyostelium discoideum DDB_G0276343 R-DDI-9013143 https://reactome.org/PathwayBrowser/#/R-DDI-9013143 RAC1 GEFs activate RAC1 IEA Dictyostelium discoideum DDB_G0276343 R-DDI-9013159 https://reactome.org/PathwayBrowser/#/R-DDI-9013159 CDC42 GEFs activate CDC42 IEA Dictyostelium discoideum DDB_G0276343 R-DDI-9860796 https://reactome.org/PathwayBrowser/#/R-DDI-9860796 Phosphorylation of PDPK1 on serine-241 IEA Dictyostelium discoideum DDB_G0276343 R-DDI-9860800 https://reactome.org/PathwayBrowser/#/R-DDI-9860800 mTORC2 phosphorylates AKT1 on serine-473 IEA Dictyostelium discoideum DDB_G0276355 R-DDI-6798751 https://reactome.org/PathwayBrowser/#/R-DDI-6798751 Exocytosis of azurophil granule lumen proteins IEA Dictyostelium discoideum DDB_G0276355 R-DDI-6809003 https://reactome.org/PathwayBrowser/#/R-DDI-6809003 ERGIC-to-Golgi vesicles bind dynein:dynactin IEA Dictyostelium discoideum DDB_G0276355 R-DDI-9646348 https://reactome.org/PathwayBrowser/#/R-DDI-9646348 PolyUb-Misfolded Proteins:HDAC6 bind dynein motor IEA Dictyostelium discoideum DDB_G0276355 R-DDI-9646685 https://reactome.org/PathwayBrowser/#/R-DDI-9646685 Aggresome dissociates from dynein and microtubule IEA Dictyostelium discoideum DDB_G0276363 R-DDI-9018766 https://reactome.org/PathwayBrowser/#/R-DDI-9018766 RHOU binds effectors at the plasma membrane IEA Dictyostelium discoideum DDB_G0276363 R-DDI-9018778 https://reactome.org/PathwayBrowser/#/R-DDI-9018778 RHOBTB1 binds interacting proteins at the endosome membrane IEA Dictyostelium discoideum DDB_G0276363 R-DDI-9018787 https://reactome.org/PathwayBrowser/#/R-DDI-9018787 RHOBTB2 binds interacting proteins at the endosome membrane IEA Dictyostelium discoideum DDB_G0276363 R-DDI-9018815 https://reactome.org/PathwayBrowser/#/R-DDI-9018815 RHOT1 binds effectors at the mitochondrial outer membrane IEA Dictyostelium discoideum DDB_G0276363 R-DDI-9018824 https://reactome.org/PathwayBrowser/#/R-DDI-9018824 RHOT2 binds effectors at the mitochondrial outer membrane IEA Dictyostelium discoideum DDB_G0276371 R-DDI-205039 https://reactome.org/PathwayBrowser/#/R-DDI-205039 p75NTR indirectly activates RAC and Cdc42 via a guanyl-nucleotide exchange factor IEA Dictyostelium discoideum DDB_G0276371 R-DDI-9013143 https://reactome.org/PathwayBrowser/#/R-DDI-9013143 RAC1 GEFs activate RAC1 IEA Dictyostelium discoideum DDB_G0276371 R-DDI-9013159 https://reactome.org/PathwayBrowser/#/R-DDI-9013159 CDC42 GEFs activate CDC42 IEA Dictyostelium discoideum DDB_G0276375 R-DDI-939763 https://reactome.org/PathwayBrowser/#/R-DDI-939763 P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane IEA Dictyostelium discoideum DDB_G0276375 R-DDI-947591 https://reactome.org/PathwayBrowser/#/R-DDI-947591 P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane IEA Dictyostelium discoideum DDB_G0276377 R-DDI-141423 https://reactome.org/PathwayBrowser/#/R-DDI-141423 Binding of the MCC complex to the APC/C complex IEA Dictyostelium discoideum DDB_G0276377 R-DDI-174057 https://reactome.org/PathwayBrowser/#/R-DDI-174057 Multiubiquitination of APC/C-associated Cdh1 IEA Dictyostelium discoideum DDB_G0276377 R-DDI-174058 https://reactome.org/PathwayBrowser/#/R-DDI-174058 Degradation of multiubiquitinated Cdh1 IEA Dictyostelium discoideum DDB_G0276377 R-DDI-174070 https://reactome.org/PathwayBrowser/#/R-DDI-174070 Association of Cdh1 with the APC/C IEA Dictyostelium discoideum DDB_G0276377 R-DDI-174079 https://reactome.org/PathwayBrowser/#/R-DDI-174079 Phosphorylation of Cdh1 by Cyclin A:Cdk2 IEA Dictyostelium discoideum DDB_G0276377 R-DDI-174088 https://reactome.org/PathwayBrowser/#/R-DDI-174088 Association of cell cycle proteins with the APC/C:Cdh1 complex IEA Dictyostelium discoideum DDB_G0276377 R-DDI-174104 https://reactome.org/PathwayBrowser/#/R-DDI-174104 Ubiquitination of Cyclin A by APC/C:Cdc20 complex IEA Dictyostelium discoideum DDB_G0276377 R-DDI-174105 https://reactome.org/PathwayBrowser/#/R-DDI-174105 Degradation of multiubiquitinated cell cycle proteins IEA Dictyostelium discoideum DDB_G0276377 R-DDI-174119 https://reactome.org/PathwayBrowser/#/R-DDI-174119 Free APC/C phosphorylated by Plk1 IEA Dictyostelium discoideum DDB_G0276377 R-DDI-174139 https://reactome.org/PathwayBrowser/#/R-DDI-174139 Dissociation of phospho-Cdh1 from the APC/C complex IEA Dictyostelium discoideum DDB_G0276377 R-DDI-174144 https://reactome.org/PathwayBrowser/#/R-DDI-174144 Ubiquitination of Securin by phospho-APC/C:Cdc20 complex IEA Dictyostelium discoideum DDB_G0276377 R-DDI-174195 https://reactome.org/PathwayBrowser/#/R-DDI-174195 Ubiquitination of cell cycle proteins targeted by the APC/C:Cdh1complex IEA Dictyostelium discoideum DDB_G0276377 R-DDI-174202 https://reactome.org/PathwayBrowser/#/R-DDI-174202 Degradation of multiubiquitinated Securin IEA Dictyostelium discoideum DDB_G0276377 R-DDI-174224 https://reactome.org/PathwayBrowser/#/R-DDI-174224 Dissociation of Cdc20 from APC/C complex IEA Dictyostelium discoideum DDB_G0276377 R-DDI-174227 https://reactome.org/PathwayBrowser/#/R-DDI-174227 Ubiquitination of Cyclin B by phospho-APC/C:Cdc20 complex IEA Dictyostelium discoideum DDB_G0276377 R-DDI-174238 https://reactome.org/PathwayBrowser/#/R-DDI-174238 Activation of APC/C:Cdc20 by dissociation of Cdc20:phospho-APC/C from Cdc20:phospho-APC/C:Mad2:Bub3:BubR1 IEA Dictyostelium discoideum DDB_G0276377 R-DDI-179410 https://reactome.org/PathwayBrowser/#/R-DDI-179410 Association of Nek2A with MCC:APC/C IEA Dictyostelium discoideum DDB_G0276377 R-DDI-179417 https://reactome.org/PathwayBrowser/#/R-DDI-179417 Multiubiquitination of Nek2A IEA Dictyostelium discoideum DDB_G0276377 R-DDI-179421 https://reactome.org/PathwayBrowser/#/R-DDI-179421 Degradation of multiubiquitinated Nek2A IEA Dictyostelium discoideum DDB_G0276377 R-DDI-188191 https://reactome.org/PathwayBrowser/#/R-DDI-188191 APC/C:Cdh1-mediated degradation of Skp2 IEA Dictyostelium discoideum DDB_G0276377 R-DDI-3788705 https://reactome.org/PathwayBrowser/#/R-DDI-3788705 CDKN1A (p21) prevents phosphorylation of Cdh1 by Cyclin A:Cdk2 IEA Dictyostelium discoideum DDB_G0276377 R-DDI-3788724 https://reactome.org/PathwayBrowser/#/R-DDI-3788724 Cdh1:APC/C ubiquitinates EHMT1 and EHMT2 IEA Dictyostelium discoideum DDB_G0276377 R-DDI-69015 https://reactome.org/PathwayBrowser/#/R-DDI-69015 Cytoplasmic phosphorylated Cdc6 is ubiquitinated by the anaphase-promoting complex IEA Dictyostelium discoideum DDB_G0276377 R-DDI-9686969 https://reactome.org/PathwayBrowser/#/R-DDI-9686969 APC/C:Cdh1 polyubiquitinates SKP2 IEA Dictyostelium discoideum DDB_G0276377 R-DDI-983140 https://reactome.org/PathwayBrowser/#/R-DDI-983140 Transfer of Ub from E2 to substrate and release of E2 IEA Dictyostelium discoideum DDB_G0276377 R-DDI-983147 https://reactome.org/PathwayBrowser/#/R-DDI-983147 Release of E3 from polyubiquitinated substrate IEA Dictyostelium discoideum DDB_G0276377 R-DDI-983156 https://reactome.org/PathwayBrowser/#/R-DDI-983156 Polyubiquitination of substrate IEA Dictyostelium discoideum DDB_G0276377 R-DDI-983157 https://reactome.org/PathwayBrowser/#/R-DDI-983157 Interaction of E3 with substrate and E2-Ub complex IEA Dictyostelium discoideum DDB_G0276399 R-DDI-210444 https://reactome.org/PathwayBrowser/#/R-DDI-210444 L-Glutamate loading of synaptic vesicle IEA Dictyostelium discoideum DDB_G0276399 R-DDI-6798739 https://reactome.org/PathwayBrowser/#/R-DDI-6798739 Exocytosis of azurophil granule membrane proteins IEA Dictyostelium discoideum DDB_G0276399 R-DDI-6798743 https://reactome.org/PathwayBrowser/#/R-DDI-6798743 Exocytosis of secretory granule membrane proteins IEA Dictyostelium discoideum DDB_G0276399 R-DDI-8870466 https://reactome.org/PathwayBrowser/#/R-DDI-8870466 RGGT:CHM binds RABs IEA Dictyostelium discoideum DDB_G0276399 R-DDI-8870469 https://reactome.org/PathwayBrowser/#/R-DDI-8870469 RGGT geranylgeranylates RAB proteins IEA Dictyostelium discoideum DDB_G0276399 R-DDI-8876454 https://reactome.org/PathwayBrowser/#/R-DDI-8876454 DENND3 exchanges GTP for GDP on RAB12 IEA Dictyostelium discoideum DDB_G0276399 R-DDI-8876615 https://reactome.org/PathwayBrowser/#/R-DDI-8876615 RAB13 GEFs exchange GTP for GDP on RAB13 IEA Dictyostelium discoideum DDB_G0276415 R-DDI-156823 https://reactome.org/PathwayBrowser/#/R-DDI-156823 Association of phospho-L13a with GAIT element of Ceruloplasmin mRNA IEA Dictyostelium discoideum DDB_G0276415 R-DDI-1799332 https://reactome.org/PathwayBrowser/#/R-DDI-1799332 Nascent polypeptide:mRNA:ribosome complex binds signal recognition particle (SRP) IEA Dictyostelium discoideum DDB_G0276415 R-DDI-72621 https://reactome.org/PathwayBrowser/#/R-DDI-72621 Ribosomal scanning IEA Dictyostelium discoideum DDB_G0276415 R-DDI-72671 https://reactome.org/PathwayBrowser/#/R-DDI-72671 eIF5B:GTP is hydrolyzed and released IEA Dictyostelium discoideum DDB_G0276415 R-DDI-72672 https://reactome.org/PathwayBrowser/#/R-DDI-72672 The 60S subunit joins the translation initiation complex IEA Dictyostelium discoideum DDB_G0276415 R-DDI-72673 https://reactome.org/PathwayBrowser/#/R-DDI-72673 Release of 40S and 60S subunits from the 80S ribosome IEA Dictyostelium discoideum DDB_G0276415 R-DDI-72676 https://reactome.org/PathwayBrowser/#/R-DDI-72676 eIF3 and eIF1A bind to the 40S subunit IEA Dictyostelium discoideum DDB_G0276415 R-DDI-72691 https://reactome.org/PathwayBrowser/#/R-DDI-72691 Formation of the 43S pre-initiation complex IEA Dictyostelium discoideum DDB_G0276415 R-DDI-72697 https://reactome.org/PathwayBrowser/#/R-DDI-72697 Start codon recognition IEA Dictyostelium discoideum DDB_G0276415 R-DDI-927789 https://reactome.org/PathwayBrowser/#/R-DDI-927789 Formation of UPF1:eRF3 complex on mRNA with a premature termination codon and no Exon Junction Complex IEA Dictyostelium discoideum DDB_G0276415 R-DDI-927832 https://reactome.org/PathwayBrowser/#/R-DDI-927832 UPF1 binds an mRNP with a termination codon preceding an Exon Junction Complex IEA Dictyostelium discoideum DDB_G0276415 R-DDI-927889 https://reactome.org/PathwayBrowser/#/R-DDI-927889 SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex) IEA Dictyostelium discoideum DDB_G0276417 R-DDI-9838081 https://reactome.org/PathwayBrowser/#/R-DDI-9838081 LONP1 degrades mitochondrial matrix proteins IEA Dictyostelium discoideum DDB_G0276417 R-DDI-9838093 https://reactome.org/PathwayBrowser/#/R-DDI-9838093 LONP1 binds mitochondrial matrix proteins IEA Dictyostelium discoideum DDB_G0276417 R-DDI-9861616 https://reactome.org/PathwayBrowser/#/R-DDI-9861616 DLD dimer dehydrogenates dihydrolipoyl IEA Dictyostelium discoideum DDB_G0276417 R-DDI-9861667 https://reactome.org/PathwayBrowser/#/R-DDI-9861667 DLAT trimer transfers acetyl to CoA IEA Dictyostelium discoideum DDB_G0276417 R-DDI-9861734 https://reactome.org/PathwayBrowser/#/R-DDI-9861734 PDH E1 decarboxylates PYR, transferring acetyl to DLAT IEA Dictyostelium discoideum DDB_G0276427 R-DDI-8867667 https://reactome.org/PathwayBrowser/#/R-DDI-8867667 OSBPs transport 25OH-CHOL from ER membrane to plasma membrane IEA Dictyostelium discoideum DDB_G0276427 R-DDI-8868402 https://reactome.org/PathwayBrowser/#/R-DDI-8868402 OSBP exchanges 25OH-CHOL with PI4P from ER membrane to Golgi membrane IEA Dictyostelium discoideum DDB_G0276441 R-DDI-156826 https://reactome.org/PathwayBrowser/#/R-DDI-156826 Dissociation of L13a from the 60s ribosomal subunit IEA Dictyostelium discoideum DDB_G0276441 R-DDI-1799332 https://reactome.org/PathwayBrowser/#/R-DDI-1799332 Nascent polypeptide:mRNA:ribosome complex binds signal recognition particle (SRP) IEA Dictyostelium discoideum DDB_G0276441 R-DDI-72671 https://reactome.org/PathwayBrowser/#/R-DDI-72671 eIF5B:GTP is hydrolyzed and released IEA Dictyostelium discoideum DDB_G0276441 R-DDI-72672 https://reactome.org/PathwayBrowser/#/R-DDI-72672 The 60S subunit joins the translation initiation complex IEA Dictyostelium discoideum DDB_G0276441 R-DDI-72673 https://reactome.org/PathwayBrowser/#/R-DDI-72673 Release of 40S and 60S subunits from the 80S ribosome IEA Dictyostelium discoideum DDB_G0276441 R-DDI-927789 https://reactome.org/PathwayBrowser/#/R-DDI-927789 Formation of UPF1:eRF3 complex on mRNA with a premature termination codon and no Exon Junction Complex IEA Dictyostelium discoideum DDB_G0276441 R-DDI-927832 https://reactome.org/PathwayBrowser/#/R-DDI-927832 UPF1 binds an mRNP with a termination codon preceding an Exon Junction Complex IEA Dictyostelium discoideum DDB_G0276441 R-DDI-927889 https://reactome.org/PathwayBrowser/#/R-DDI-927889 SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex) IEA Dictyostelium discoideum DDB_G0276443 R-DDI-5689950 https://reactome.org/PathwayBrowser/#/R-DDI-5689950 USP7 deubiquitinates TP53,MDM2,MDM4,FOXO4, PTEN IEA Dictyostelium discoideum DDB_G0276443 R-DDI-5696564 https://reactome.org/PathwayBrowser/#/R-DDI-5696564 USP25 deubiquitinates DDX58 IEA Dictyostelium discoideum DDB_G0276443 R-DDI-6782069 https://reactome.org/PathwayBrowser/#/R-DDI-6782069 UVSSA:USP7 deubiquitinates ERCC6 IEA Dictyostelium discoideum DDB_G0276443 R-DDI-6782131 https://reactome.org/PathwayBrowser/#/R-DDI-6782131 ERCC2-facilitated RNA Pol II backtracking in TC-NER IEA Dictyostelium discoideum DDB_G0276443 R-DDI-6782141 https://reactome.org/PathwayBrowser/#/R-DDI-6782141 Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in TC-NER IEA Dictyostelium discoideum DDB_G0276443 R-DDI-6782204 https://reactome.org/PathwayBrowser/#/R-DDI-6782204 5' incision of damaged DNA strand by ERCC1:ERCC4 in TC-NER IEA Dictyostelium discoideum DDB_G0276443 R-DDI-6782208 https://reactome.org/PathwayBrowser/#/R-DDI-6782208 Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in TC-NER IEA Dictyostelium discoideum DDB_G0276443 R-DDI-6782211 https://reactome.org/PathwayBrowser/#/R-DDI-6782211 DNA polymerases delta, epsilon or kappa bind the TC-NER site IEA Dictyostelium discoideum DDB_G0276443 R-DDI-6782227 https://reactome.org/PathwayBrowser/#/R-DDI-6782227 Ligation of newly synthesized repair patch to incised DNA in TC-NER IEA Dictyostelium discoideum DDB_G0276443 R-DDI-6807118 https://reactome.org/PathwayBrowser/#/R-DDI-6807118 USP7 deubiquitinates monoubiquitinated PTEN IEA Dictyostelium discoideum DDB_G0276443 R-DDI-8853503 https://reactome.org/PathwayBrowser/#/R-DDI-8853503 UCHL3,USP7,USP9X cleaves RPS27A yielding ubiquitin IEA Dictyostelium discoideum DDB_G0276443 R-DDI-8853514 https://reactome.org/PathwayBrowser/#/R-DDI-8853514 UCHL3,USP7,USP9X cleaves UBA52 yielding ubiquitin IEA Dictyostelium discoideum DDB_G0276443 R-DDI-9684118 https://reactome.org/PathwayBrowser/#/R-DDI-9684118 ERCC3-facilitated RNA Pol II backtracking in TC-NER IEA Dictyostelium discoideum DDB_G0276445 R-DDI-5251942 https://reactome.org/PathwayBrowser/#/R-DDI-5251942 Hikeshi binds HSP70s:ATP IEA Dictyostelium discoideum DDB_G0276445 R-DDI-5251955 https://reactome.org/PathwayBrowser/#/R-DDI-5251955 HSP40s activate intrinsic ATPase activity of HSP70s in the nucleoplasm IEA Dictyostelium discoideum DDB_G0276445 R-DDI-5251959 https://reactome.org/PathwayBrowser/#/R-DDI-5251959 HSP40s activate intrinsic ATPase activity of HSP70s in the cytosol IEA Dictyostelium discoideum DDB_G0276445 R-DDI-5252079 https://reactome.org/PathwayBrowser/#/R-DDI-5252079 HSP110s exchange ATP for ADP on HSP70s:ADP IEA Dictyostelium discoideum DDB_G0276453 R-DDI-6798748 https://reactome.org/PathwayBrowser/#/R-DDI-6798748 Exocytosis of secretory granule lumen proteins IEA Dictyostelium discoideum DDB_G0276453 R-DDI-6800434 https://reactome.org/PathwayBrowser/#/R-DDI-6800434 Exocytosis of ficolin-rich granule lumen proteins IEA Dictyostelium discoideum DDB_G0276455 R-DDI-111879 https://reactome.org/PathwayBrowser/#/R-DDI-111879 PIP2 hydrolysis IEA Dictyostelium discoideum DDB_G0276455 R-DDI-112037 https://reactome.org/PathwayBrowser/#/R-DDI-112037 Inactivation of PLC beta IEA Dictyostelium discoideum DDB_G0276455 R-DDI-114688 https://reactome.org/PathwayBrowser/#/R-DDI-114688 PLC-beta hydrolyses PIP2 to DAG and IP3 IEA Dictyostelium discoideum DDB_G0276455 R-DDI-167415 https://reactome.org/PathwayBrowser/#/R-DDI-167415 G-protein alpha subunit is inactivated IEA Dictyostelium discoideum DDB_G0276455 R-DDI-170666 https://reactome.org/PathwayBrowser/#/R-DDI-170666 Adenylate cyclase increases the GTPase activity of G alpha-olf IEA Dictyostelium discoideum DDB_G0276455 R-DDI-170671 https://reactome.org/PathwayBrowser/#/R-DDI-170671 G alpha-olf:GTP binds to Gi alpha1:GTP:adenylate cyclase complex IEA Dictyostelium discoideum DDB_G0276455 R-DDI-170672 https://reactome.org/PathwayBrowser/#/R-DDI-170672 Galpha-olf:GTP binds to adenylate cyclase and activates it IEA Dictyostelium discoideum DDB_G0276455 R-DDI-170674 https://reactome.org/PathwayBrowser/#/R-DDI-170674 Dissociation of the Gi alpha:G olf complex IEA Dictyostelium discoideum DDB_G0276455 R-DDI-170676 https://reactome.org/PathwayBrowser/#/R-DDI-170676 Adenylate cyclase converts ATP into cyclic AMP IEA Dictyostelium discoideum DDB_G0276455 R-DDI-170677 https://reactome.org/PathwayBrowser/#/R-DDI-170677 The G alpha-olf:GDP:Adenylate cyclase complex dissociates IEA Dictyostelium discoideum DDB_G0276455 R-DDI-170685 https://reactome.org/PathwayBrowser/#/R-DDI-170685 Adenylaye cyclase increases the GTPase activity of G alpha-olf IEA Dictyostelium discoideum DDB_G0276455 R-DDI-170686 https://reactome.org/PathwayBrowser/#/R-DDI-170686 Adenylate cyclase increases the GTPase activity of Gi alpha IEA Dictyostelium discoideum DDB_G0276455 R-DDI-399998 https://reactome.org/PathwayBrowser/#/R-DDI-399998 Activated Phospholipase C beta-1 hydrolyzes 1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate IEA Dictyostelium discoideum DDB_G0276455 R-DDI-418574 https://reactome.org/PathwayBrowser/#/R-DDI-418574 G alpha (12/13) auto-inactivates by hydrolysing GTP to GDP IEA Dictyostelium discoideum DDB_G0276455 R-DDI-418582 https://reactome.org/PathwayBrowser/#/R-DDI-418582 G alpha (q) auto-inactivates by hydrolysing GTP to GDP IEA Dictyostelium discoideum DDB_G0276455 R-DDI-428941 https://reactome.org/PathwayBrowser/#/R-DDI-428941 P2Y purinoceptor 1 activates MAP kinase p38 alpha IEA Dictyostelium discoideum DDB_G0276455 R-DDI-8982017 https://reactome.org/PathwayBrowser/#/R-DDI-8982017 Active G alpha (q) binds RGS proteins IEA Dictyostelium discoideum DDB_G0276455 R-DDI-8982025 https://reactome.org/PathwayBrowser/#/R-DDI-8982025 G alpha (q) in G (q):RGS complex is inactivated IEA Dictyostelium discoideum DDB_G0276455 R-DDI-8982026 https://reactome.org/PathwayBrowser/#/R-DDI-8982026 G alpha (q):RGS dissociates to inactive G alpha (q) IEA Dictyostelium discoideum DDB_G0276455 R-DDI-9013143 https://reactome.org/PathwayBrowser/#/R-DDI-9013143 RAC1 GEFs activate RAC1 IEA Dictyostelium discoideum DDB_G0276455 R-DDI-9013159 https://reactome.org/PathwayBrowser/#/R-DDI-9013159 CDC42 GEFs activate CDC42 IEA Dictyostelium discoideum DDB_G0276455 R-DDI-9860796 https://reactome.org/PathwayBrowser/#/R-DDI-9860796 Phosphorylation of PDPK1 on serine-241 IEA Dictyostelium discoideum DDB_G0276455 R-DDI-9860800 https://reactome.org/PathwayBrowser/#/R-DDI-9860800 mTORC2 phosphorylates AKT1 on serine-473 IEA Dictyostelium discoideum DDB_G0276457 R-DDI-156823 https://reactome.org/PathwayBrowser/#/R-DDI-156823 Association of phospho-L13a with GAIT element of Ceruloplasmin mRNA IEA Dictyostelium discoideum DDB_G0276457 R-DDI-1799332 https://reactome.org/PathwayBrowser/#/R-DDI-1799332 Nascent polypeptide:mRNA:ribosome complex binds signal recognition particle (SRP) IEA Dictyostelium discoideum DDB_G0276457 R-DDI-72621 https://reactome.org/PathwayBrowser/#/R-DDI-72621 Ribosomal scanning IEA Dictyostelium discoideum DDB_G0276457 R-DDI-72671 https://reactome.org/PathwayBrowser/#/R-DDI-72671 eIF5B:GTP is hydrolyzed and released IEA Dictyostelium discoideum DDB_G0276457 R-DDI-72672 https://reactome.org/PathwayBrowser/#/R-DDI-72672 The 60S subunit joins the translation initiation complex IEA Dictyostelium discoideum DDB_G0276457 R-DDI-72673 https://reactome.org/PathwayBrowser/#/R-DDI-72673 Release of 40S and 60S subunits from the 80S ribosome IEA Dictyostelium discoideum DDB_G0276457 R-DDI-72676 https://reactome.org/PathwayBrowser/#/R-DDI-72676 eIF3 and eIF1A bind to the 40S subunit IEA Dictyostelium discoideum DDB_G0276457 R-DDI-72691 https://reactome.org/PathwayBrowser/#/R-DDI-72691 Formation of the 43S pre-initiation complex IEA Dictyostelium discoideum DDB_G0276457 R-DDI-72697 https://reactome.org/PathwayBrowser/#/R-DDI-72697 Start codon recognition IEA Dictyostelium discoideum DDB_G0276457 R-DDI-927789 https://reactome.org/PathwayBrowser/#/R-DDI-927789 Formation of UPF1:eRF3 complex on mRNA with a premature termination codon and no Exon Junction Complex IEA Dictyostelium discoideum DDB_G0276457 R-DDI-927832 https://reactome.org/PathwayBrowser/#/R-DDI-927832 UPF1 binds an mRNP with a termination codon preceding an Exon Junction Complex IEA Dictyostelium discoideum DDB_G0276457 R-DDI-927889 https://reactome.org/PathwayBrowser/#/R-DDI-927889 SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex) IEA Dictyostelium discoideum DDB_G0276459 R-DDI-389788 https://reactome.org/PathwayBrowser/#/R-DDI-389788 Activation of PAKs by RAC1 and CDC42 IEA Dictyostelium discoideum DDB_G0276459 R-DDI-5627775 https://reactome.org/PathwayBrowser/#/R-DDI-5627775 Autophosphorylation of PAK1,2,3 IEA Dictyostelium discoideum DDB_G0276459 R-DDI-5668932 https://reactome.org/PathwayBrowser/#/R-DDI-5668932 PAK2 phosphorylates myosin regulatory light chain (MRLC) IEA Dictyostelium discoideum DDB_G0276459 R-DDI-5687086 https://reactome.org/PathwayBrowser/#/R-DDI-5687086 PAK1,2,3 phosphorylates MAPK6,4 IEA Dictyostelium discoideum DDB_G0276459 R-DDI-8981926 https://reactome.org/PathwayBrowser/#/R-DDI-8981926 RAC1 and CDC42 activate PAK3 IEA Dictyostelium discoideum DDB_G0276459 R-DDI-8981931 https://reactome.org/PathwayBrowser/#/R-DDI-8981931 RAC1 and CDC42 activate PAK2 IEA Dictyostelium discoideum DDB_G0276459 R-DDI-9013145 https://reactome.org/PathwayBrowser/#/R-DDI-9013145 RAC1 binds effectors at the plasma membrane IEA Dictyostelium discoideum DDB_G0276459 R-DDI-9014294 https://reactome.org/PathwayBrowser/#/R-DDI-9014294 RAC2 binds effectors at the plasma membrane IEA Dictyostelium discoideum DDB_G0276459 R-DDI-9014449 https://reactome.org/PathwayBrowser/#/R-DDI-9014449 RHOG binds effectors at the plasma membrane IEA Dictyostelium discoideum DDB_G0276459 R-DDI-9018746 https://reactome.org/PathwayBrowser/#/R-DDI-9018746 RHOQ binds effectors at the plasma membrane IEA Dictyostelium discoideum DDB_G0276459 R-DDI-9018758 https://reactome.org/PathwayBrowser/#/R-DDI-9018758 RHOH binds effectors at the plasma membrane IEA Dictyostelium discoideum DDB_G0276459 R-DDI-9018766 https://reactome.org/PathwayBrowser/#/R-DDI-9018766 RHOU binds effectors at the plasma membrane IEA Dictyostelium discoideum DDB_G0276459 R-DDI-9018794 https://reactome.org/PathwayBrowser/#/R-DDI-9018794 RHOV binds effectors at the plasma membrane IEA Dictyostelium discoideum DDB_G0276459 R-DDI-9018808 https://reactome.org/PathwayBrowser/#/R-DDI-9018808 RAC3 binds effectors at the plasma membrane IEA Dictyostelium discoideum DDB_G0276465 R-DDI-2730868 https://reactome.org/PathwayBrowser/#/R-DDI-2730868 Phosphorylation of MEK7 by MEKK1 IEA Dictyostelium discoideum DDB_G0276465 R-DDI-2730896 https://reactome.org/PathwayBrowser/#/R-DDI-2730896 Phosphorylation of MEK4 by MEKK1 IEA Dictyostelium discoideum DDB_G0276479 R-DDI-6798751 https://reactome.org/PathwayBrowser/#/R-DDI-6798751 Exocytosis of azurophil granule lumen proteins IEA Dictyostelium discoideum DDB_G0276479 R-DDI-8876472 https://reactome.org/PathwayBrowser/#/R-DDI-8876472 NPC2 binds CHOL IEA Dictyostelium discoideum DDB_G0276479 R-DDI-8876484 https://reactome.org/PathwayBrowser/#/R-DDI-8876484 NPC2 transfers CHOL to NPC1 IEA Dictyostelium discoideum DDB_G0276481 R-DDI-6781833 https://reactome.org/PathwayBrowser/#/R-DDI-6781833 ERCC8 (CSA) binds stalled RNA Pol II IEA Dictyostelium discoideum DDB_G0276481 R-DDI-6781867 https://reactome.org/PathwayBrowser/#/R-DDI-6781867 ERCC8:DDB1:CUL4:RBX1 ubiquitinates ERCC6 and RNA Pol II IEA Dictyostelium discoideum DDB_G0276481 R-DDI-6782069 https://reactome.org/PathwayBrowser/#/R-DDI-6782069 UVSSA:USP7 deubiquitinates ERCC6 IEA Dictyostelium discoideum DDB_G0276481 R-DDI-6782131 https://reactome.org/PathwayBrowser/#/R-DDI-6782131 ERCC2-facilitated RNA Pol II backtracking in TC-NER IEA Dictyostelium discoideum DDB_G0276481 R-DDI-6782141 https://reactome.org/PathwayBrowser/#/R-DDI-6782141 Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in TC-NER IEA Dictyostelium discoideum DDB_G0276481 R-DDI-6782204 https://reactome.org/PathwayBrowser/#/R-DDI-6782204 5' incision of damaged DNA strand by ERCC1:ERCC4 in TC-NER IEA Dictyostelium discoideum DDB_G0276481 R-DDI-6782208 https://reactome.org/PathwayBrowser/#/R-DDI-6782208 Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in TC-NER IEA Dictyostelium discoideum DDB_G0276481 R-DDI-6782211 https://reactome.org/PathwayBrowser/#/R-DDI-6782211 DNA polymerases delta, epsilon or kappa bind the TC-NER site IEA Dictyostelium discoideum DDB_G0276481 R-DDI-6782227 https://reactome.org/PathwayBrowser/#/R-DDI-6782227 Ligation of newly synthesized repair patch to incised DNA in TC-NER IEA Dictyostelium discoideum DDB_G0276481 R-DDI-8952638 https://reactome.org/PathwayBrowser/#/R-DDI-8952638 AcM-UBE2M transfers NEDD8 to CRL4 E3 ubiquitin ligase complex IEA Dictyostelium discoideum DDB_G0276481 R-DDI-8952639 https://reactome.org/PathwayBrowser/#/R-DDI-8952639 NEDD8:AcM-UBE2M binds CRL4 E3 ubiquitin ligase complex IEA Dictyostelium discoideum DDB_G0276481 R-DDI-8955245 https://reactome.org/PathwayBrowser/#/R-DDI-8955245 CAND1 binds CRL4 E3 ubiquitin ligase in the nucleus IEA Dictyostelium discoideum DDB_G0276481 R-DDI-8955285 https://reactome.org/PathwayBrowser/#/R-DDI-8955285 COMMDs displace CAND1 from CRL4 E3 ubiquitin ligase complex IEA Dictyostelium discoideum DDB_G0276481 R-DDI-8956045 https://reactome.org/PathwayBrowser/#/R-DDI-8956045 COP9 signalosome deneddylates nuclear CRL4 E3 ubiquitin ligase complex IEA Dictyostelium discoideum DDB_G0276481 R-DDI-9684118 https://reactome.org/PathwayBrowser/#/R-DDI-9684118 ERCC3-facilitated RNA Pol II backtracking in TC-NER IEA Dictyostelium discoideum DDB_G0276549 R-DDI-392513 https://reactome.org/PathwayBrowser/#/R-DDI-392513 Rap1 signal termination by Rap1GAPs IEA Dictyostelium discoideum DDB_G0276567 R-DDI-6798739 https://reactome.org/PathwayBrowser/#/R-DDI-6798739 Exocytosis of azurophil granule membrane proteins IEA Dictyostelium discoideum DDB_G0276567 R-DDI-6799350 https://reactome.org/PathwayBrowser/#/R-DDI-6799350 Exocytosis of specific granule membrane proteins IEA Dictyostelium discoideum DDB_G0276571 R-DDI-6798748 https://reactome.org/PathwayBrowser/#/R-DDI-6798748 Exocytosis of secretory granule lumen proteins IEA Dictyostelium discoideum DDB_G0276571 R-DDI-6800434 https://reactome.org/PathwayBrowser/#/R-DDI-6800434 Exocytosis of ficolin-rich granule lumen proteins IEA Dictyostelium discoideum DDB_G0276575 R-DDI-6811433 https://reactome.org/PathwayBrowser/#/R-DDI-6811433 The COG tethering complex interacts with numerous SNAREs at the Golgi membrane IEA Dictyostelium discoideum DDB_G0276575 R-DDI-6814676 https://reactome.org/PathwayBrowser/#/R-DDI-6814676 SNAPs and NSF hexamer bind cis-SNARE at the TGN IEA Dictyostelium discoideum DDB_G0276575 R-DDI-6814678 https://reactome.org/PathwayBrowser/#/R-DDI-6814678 ATP hydrolysis by NSF disassembles the cis-SNARE at the TGN IEA Dictyostelium discoideum DDB_G0276575 R-DDI-6814684 https://reactome.org/PathwayBrowser/#/R-DDI-6814684 cis-SNARE binds SNAPs and NSF hexamer at the TGN IEA Dictyostelium discoideum DDB_G0276625 R-DDI-174368 https://reactome.org/PathwayBrowser/#/R-DDI-174368 SLC35D1 hexamer transports UDP-GlcA, UDP-GlcNAc from cytosol to endoplasmic reticulum lumen IEA Dictyostelium discoideum DDB_G0276625 R-DDI-744230 https://reactome.org/PathwayBrowser/#/R-DDI-744230 SLC35D2 mediates the antiport of GDP-mannose in exchange for GMP IEA Dictyostelium discoideum DDB_G0276625 R-DDI-744231 https://reactome.org/PathwayBrowser/#/R-DDI-744231 SLC35D2 exchanges UDP-GlcNAc for UMP IEA Dictyostelium discoideum DDB_G0276625 R-DDI-9792608 https://reactome.org/PathwayBrowser/#/R-DDI-9792608 SLC35D2 exchanges UDP-D-glucose for UMP IEA Dictyostelium discoideum DDB_G0276657 R-DDI-265456 https://reactome.org/PathwayBrowser/#/R-DDI-265456 NPC1L1 binds ezetimibe IEA Dictyostelium discoideum DDB_G0276657 R-DDI-8876484 https://reactome.org/PathwayBrowser/#/R-DDI-8876484 NPC2 transfers CHOL to NPC1 IEA Dictyostelium discoideum DDB_G0276657 R-DDI-8876485 https://reactome.org/PathwayBrowser/#/R-DDI-8876485 CHOL translocates from lysosome membrane to ER membrane IEA Dictyostelium discoideum DDB_G0276661 R-DDI-5693807 https://reactome.org/PathwayBrowser/#/R-DDI-5693807 FUCA1 hydrolyses NGP:1,6-GlcNAc IEA Dictyostelium discoideum DDB_G0276661 R-DDI-6798751 https://reactome.org/PathwayBrowser/#/R-DDI-6798751 Exocytosis of azurophil granule lumen proteins IEA Dictyostelium discoideum DDB_G0276663 R-DDI-427555 https://reactome.org/PathwayBrowser/#/R-DDI-427555 SLC26A1,2 cotransport SO4(2-), H+ from extracellular region to cytosol IEA Dictyostelium discoideum DDB_G0276663 R-DDI-427570 https://reactome.org/PathwayBrowser/#/R-DDI-427570 Group 3 - Selective Cl- transport IEA Dictyostelium discoideum DDB_G0276663 R-DDI-427666 https://reactome.org/PathwayBrowser/#/R-DDI-427666 SLC26A3,6 exchange Cl- for HCO3- IEA Dictyostelium discoideum DDB_G0276663 R-DDI-5627802 https://reactome.org/PathwayBrowser/#/R-DDI-5627802 SLC26A4 transports I- from cytosol to extracellular region IEA Dictyostelium discoideum DDB_G0276663 R-DDI-8875871 https://reactome.org/PathwayBrowser/#/R-DDI-8875871 SLC26A11 transports SO4(2-) from extracellular region to cytosol IEA Dictyostelium discoideum DDB_G0276673 R-DDI-9639287 https://reactome.org/PathwayBrowser/#/R-DDI-9639287 SESN1,2 binds L-leucine and dissociates from GATOR2 IEA Dictyostelium discoideum DDB_G0276673 R-DDI-9640195 https://reactome.org/PathwayBrowser/#/R-DDI-9640195 RRAGA,B hydrolyzes GTP IEA Dictyostelium discoideum DDB_G0276711 R-DDI-177784 https://reactome.org/PathwayBrowser/#/R-DDI-177784 ribose 5-phosphate <=> D-ribulose 5-phosphate IEA Dictyostelium discoideum DDB_G0276711 R-DDI-71306 https://reactome.org/PathwayBrowser/#/R-DDI-71306 D-ribulose 5-phosphate <=> ribose 5-phosphate IEA Dictyostelium discoideum DDB_G0276763 R-DDI-1482962 https://reactome.org/PathwayBrowser/#/R-DDI-1482962 CDP-ETA and DAG are converted to PE by CEPT1/EPT1 IEA Dictyostelium discoideum DDB_G0276763 R-DDI-1482973 https://reactome.org/PathwayBrowser/#/R-DDI-1482973 CDP-Cho and DAG are converted to PC by CHPT1 at the Golgi membrane IEA Dictyostelium discoideum DDB_G0276765 R-DDI-1022127 https://reactome.org/PathwayBrowser/#/R-DDI-1022127 Ub-unfolded protein:(GlcNAc)2 (Man)9-5 translocates from ERQC to cytosol IEA Dictyostelium discoideum DDB_G0276765 R-DDI-1358789 https://reactome.org/PathwayBrowser/#/R-DDI-1358789 Self-ubiquitination of RNF41 IEA Dictyostelium discoideum DDB_G0276765 R-DDI-1358795 https://reactome.org/PathwayBrowser/#/R-DDI-1358795 Deubiquitination of RNF41 by P-USP8 IEA Dictyostelium discoideum DDB_G0276765 R-DDI-1358797 https://reactome.org/PathwayBrowser/#/R-DDI-1358797 Ubiquitinated RNF41 binds P-USP8 IEA Dictyostelium discoideum DDB_G0276765 R-DDI-1363331 https://reactome.org/PathwayBrowser/#/R-DDI-1363331 Ubiquitination of p130 (RBL2) by SCF (Skp2) IEA Dictyostelium discoideum DDB_G0276765 R-DDI-1504190 https://reactome.org/PathwayBrowser/#/R-DDI-1504190 DVL is ubiquitinated by CUL3:KLHL12:RBX1 IEA Dictyostelium discoideum DDB_G0276765 R-DDI-1504193 https://reactome.org/PathwayBrowser/#/R-DDI-1504193 Ubiquitinated DVL is degraded by the proteasome IEA Dictyostelium discoideum DDB_G0276765 R-DDI-156823 https://reactome.org/PathwayBrowser/#/R-DDI-156823 Association of phospho-L13a with GAIT element of Ceruloplasmin mRNA IEA Dictyostelium discoideum DDB_G0276765 R-DDI-174057 https://reactome.org/PathwayBrowser/#/R-DDI-174057 Multiubiquitination of APC/C-associated Cdh1 IEA Dictyostelium discoideum DDB_G0276765 R-DDI-174058 https://reactome.org/PathwayBrowser/#/R-DDI-174058 Degradation of multiubiquitinated Cdh1 IEA Dictyostelium discoideum DDB_G0276765 R-DDI-174104 https://reactome.org/PathwayBrowser/#/R-DDI-174104 Ubiquitination of Cyclin A by APC/C:Cdc20 complex IEA Dictyostelium discoideum DDB_G0276765 R-DDI-174105 https://reactome.org/PathwayBrowser/#/R-DDI-174105 Degradation of multiubiquitinated cell cycle proteins IEA Dictyostelium discoideum DDB_G0276765 R-DDI-174144 https://reactome.org/PathwayBrowser/#/R-DDI-174144 Ubiquitination of Securin by phospho-APC/C:Cdc20 complex IEA Dictyostelium discoideum DDB_G0276765 R-DDI-174195 https://reactome.org/PathwayBrowser/#/R-DDI-174195 Ubiquitination of cell cycle proteins targeted by the APC/C:Cdh1complex IEA Dictyostelium discoideum DDB_G0276765 R-DDI-174202 https://reactome.org/PathwayBrowser/#/R-DDI-174202 Degradation of multiubiquitinated Securin IEA Dictyostelium discoideum DDB_G0276765 R-DDI-174227 https://reactome.org/PathwayBrowser/#/R-DDI-174227 Ubiquitination of Cyclin B by phospho-APC/C:Cdc20 complex IEA Dictyostelium discoideum DDB_G0276765 R-DDI-179417 https://reactome.org/PathwayBrowser/#/R-DDI-179417 Multiubiquitination of Nek2A IEA Dictyostelium discoideum DDB_G0276765 R-DDI-179421 https://reactome.org/PathwayBrowser/#/R-DDI-179421 Degradation of multiubiquitinated Nek2A IEA Dictyostelium discoideum DDB_G0276765 R-DDI-1799332 https://reactome.org/PathwayBrowser/#/R-DDI-1799332 Nascent polypeptide:mRNA:ribosome complex binds signal recognition particle (SRP) IEA Dictyostelium discoideum DDB_G0276765 R-DDI-188191 https://reactome.org/PathwayBrowser/#/R-DDI-188191 APC/C:Cdh1-mediated degradation of Skp2 IEA Dictyostelium discoideum DDB_G0276765 R-DDI-264444 https://reactome.org/PathwayBrowser/#/R-DDI-264444 Autoubiquitination of phospho-COP1(Ser-387 ) IEA Dictyostelium discoideum DDB_G0276765 R-DDI-264458 https://reactome.org/PathwayBrowser/#/R-DDI-264458 Proteasome mediated degradation of COP1 IEA Dictyostelium discoideum DDB_G0276765 R-DDI-3788724 https://reactome.org/PathwayBrowser/#/R-DDI-3788724 Cdh1:APC/C ubiquitinates EHMT1 and EHMT2 IEA Dictyostelium discoideum DDB_G0276765 R-DDI-446877 https://reactome.org/PathwayBrowser/#/R-DDI-446877 TRAF6 is K63 poly-ubiquitinated IEA Dictyostelium discoideum DDB_G0276765 R-DDI-450580 https://reactome.org/PathwayBrowser/#/R-DDI-450580 AUF1 (hnRNP D0) is ubiquitinylated IEA Dictyostelium discoideum DDB_G0276765 R-DDI-451418 https://reactome.org/PathwayBrowser/#/R-DDI-451418 Pellino ubiquitinates IRAK1 IEA Dictyostelium discoideum DDB_G0276765 R-DDI-5362412 https://reactome.org/PathwayBrowser/#/R-DDI-5362412 SYVN1 ubiquitinates Hh C-terminal fragments IEA Dictyostelium discoideum DDB_G0276765 R-DDI-5635854 https://reactome.org/PathwayBrowser/#/R-DDI-5635854 GLI2,3 are degraded by the proteasome IEA Dictyostelium discoideum DDB_G0276765 R-DDI-5635856 https://reactome.org/PathwayBrowser/#/R-DDI-5635856 SPOP:CUL3:RBX1 ubiquitinates GLI2,3 IEA Dictyostelium discoideum DDB_G0276765 R-DDI-5652009 https://reactome.org/PathwayBrowser/#/R-DDI-5652009 RAD18:UBE2B or RBX1:CUL4:DDB1:DTL monoubiquitinates PCNA IEA Dictyostelium discoideum DDB_G0276765 R-DDI-5655892 https://reactome.org/PathwayBrowser/#/R-DDI-5655892 POLK incorporates dNMP opposite to damaged DNA base IEA Dictyostelium discoideum DDB_G0276765 R-DDI-5658424 https://reactome.org/PathwayBrowser/#/R-DDI-5658424 KBTBD7:CUL3:RBX1 ubiquitinates NF1 IEA Dictyostelium discoideum DDB_G0276765 R-DDI-5687112 https://reactome.org/PathwayBrowser/#/R-DDI-5687112 MAPK6 is degraded by the 26S proteasome IEA Dictyostelium discoideum DDB_G0276765 R-DDI-5688797 https://reactome.org/PathwayBrowser/#/R-DDI-5688797 ATXN3 family cleave Ub chains IEA Dictyostelium discoideum DDB_G0276765 R-DDI-5689111 https://reactome.org/PathwayBrowser/#/R-DDI-5689111 PARK2 autoubiquitinates IEA Dictyostelium discoideum DDB_G0276765 R-DDI-5689950 https://reactome.org/PathwayBrowser/#/R-DDI-5689950 USP7 deubiquitinates TP53,MDM2,MDM4,FOXO4, PTEN IEA Dictyostelium discoideum DDB_G0276765 R-DDI-5690080 https://reactome.org/PathwayBrowser/#/R-DDI-5690080 USP3,SAGA deubiquitinate Histone H2A,H2B IEA Dictyostelium discoideum DDB_G0276765 R-DDI-5690152 https://reactome.org/PathwayBrowser/#/R-DDI-5690152 USP5 cleaves polyubiquitin IEA Dictyostelium discoideum DDB_G0276765 R-DDI-5690157 https://reactome.org/PathwayBrowser/#/R-DDI-5690157 USP16,USP21 deubiquitinate Histone H2A IEA Dictyostelium discoideum DDB_G0276765 R-DDI-5690159 https://reactome.org/PathwayBrowser/#/R-DDI-5690159 USP21 deubiquitinates RIPK1,DDX58 IEA Dictyostelium discoideum DDB_G0276765 R-DDI-5690319 https://reactome.org/PathwayBrowser/#/R-DDI-5690319 UCHL1, UCHL3 cleave ubiquitin adducts IEA Dictyostelium discoideum DDB_G0276765 R-DDI-5690996 https://reactome.org/PathwayBrowser/#/R-DDI-5690996 ERCC2 and ERCC3 DNA helicases form an open bubble structure in damaged DNA IEA Dictyostelium discoideum DDB_G0276765 R-DDI-5691000 https://reactome.org/PathwayBrowser/#/R-DDI-5691000 TFIIH binds GG-NER site to form a verification complex IEA Dictyostelium discoideum DDB_G0276765 R-DDI-5691001 https://reactome.org/PathwayBrowser/#/R-DDI-5691001 Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in GG-NER IEA Dictyostelium discoideum DDB_G0276765 R-DDI-5691108 https://reactome.org/PathwayBrowser/#/R-DDI-5691108 SKP1:FBXL5:CUL1:NEDD8 ubiquitinylates IREB2 IEA Dictyostelium discoideum DDB_G0276765 R-DDI-5691381 https://reactome.org/PathwayBrowser/#/R-DDI-5691381 MYSM1 deubiquitinates Histone H2A IEA Dictyostelium discoideum DDB_G0276765 R-DDI-5691431 https://reactome.org/PathwayBrowser/#/R-DDI-5691431 PSMD14 cleaves K63-linked ubiquitin IEA Dictyostelium discoideum DDB_G0276765 R-DDI-5696547 https://reactome.org/PathwayBrowser/#/R-DDI-5696547 STAMBPL1 is a deubiquitinase IEA Dictyostelium discoideum DDB_G0276765 R-DDI-5696564 https://reactome.org/PathwayBrowser/#/R-DDI-5696564 USP25 deubiquitinates DDX58 IEA Dictyostelium discoideum DDB_G0276765 R-DDI-5696600 https://reactome.org/PathwayBrowser/#/R-DDI-5696600 USP17 deubiquitinates RCE1, CDC25A, DDX58, IFIH1 IEA Dictyostelium discoideum DDB_G0276765 R-DDI-5696605 https://reactome.org/PathwayBrowser/#/R-DDI-5696605 USP12, USP26 deubiquitinate AR IEA Dictyostelium discoideum DDB_G0276765 R-DDI-5696655 https://reactome.org/PathwayBrowser/#/R-DDI-5696655 PARP1 or PARP2 PARylates DDB2 and autoPARylates IEA Dictyostelium discoideum DDB_G0276765 R-DDI-5696664 https://reactome.org/PathwayBrowser/#/R-DDI-5696664 PARP1 or PARP2 binds DDB2 at GG-NER site IEA Dictyostelium discoideum DDB_G0276765 R-DDI-5696958 https://reactome.org/PathwayBrowser/#/R-DDI-5696958 USP44 deubiquitinates CDC20 IEA Dictyostelium discoideum DDB_G0276765 R-DDI-5696960 https://reactome.org/PathwayBrowser/#/R-DDI-5696960 USP49 deubiquitinates H2B IEA Dictyostelium discoideum DDB_G0276765 R-DDI-6781779 https://reactome.org/PathwayBrowser/#/R-DDI-6781779 USP13 deubiquitinates BECN1,USP10 IEA Dictyostelium discoideum DDB_G0276765 R-DDI-6781814 https://reactome.org/PathwayBrowser/#/R-DDI-6781814 USP19 deubiquitinates RNF123 IEA Dictyostelium discoideum DDB_G0276765 R-DDI-6781867 https://reactome.org/PathwayBrowser/#/R-DDI-6781867 ERCC8:DDB1:CUL4:RBX1 ubiquitinates ERCC6 and RNA Pol II IEA Dictyostelium discoideum DDB_G0276765 R-DDI-6782069 https://reactome.org/PathwayBrowser/#/R-DDI-6782069 UVSSA:USP7 deubiquitinates ERCC6 IEA Dictyostelium discoideum DDB_G0276765 R-DDI-6782131 https://reactome.org/PathwayBrowser/#/R-DDI-6782131 ERCC2-facilitated RNA Pol II backtracking in TC-NER IEA Dictyostelium discoideum DDB_G0276765 R-DDI-6782141 https://reactome.org/PathwayBrowser/#/R-DDI-6782141 Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in TC-NER IEA Dictyostelium discoideum DDB_G0276765 R-DDI-6782204 https://reactome.org/PathwayBrowser/#/R-DDI-6782204 5' incision of damaged DNA strand by ERCC1:ERCC4 in TC-NER IEA Dictyostelium discoideum DDB_G0276765 R-DDI-6782208 https://reactome.org/PathwayBrowser/#/R-DDI-6782208 Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in TC-NER IEA Dictyostelium discoideum DDB_G0276765 R-DDI-6782211 https://reactome.org/PathwayBrowser/#/R-DDI-6782211 DNA polymerases delta, epsilon or kappa bind the TC-NER site IEA Dictyostelium discoideum DDB_G0276765 R-DDI-6782227 https://reactome.org/PathwayBrowser/#/R-DDI-6782227 Ligation of newly synthesized repair patch to incised DNA in TC-NER IEA Dictyostelium discoideum DDB_G0276765 R-DDI-6782820 https://reactome.org/PathwayBrowser/#/R-DDI-6782820 USP17 deubiquitinates SUDS3 IEA Dictyostelium discoideum DDB_G0276765 R-DDI-6782943 https://reactome.org/PathwayBrowser/#/R-DDI-6782943 UV-DDB ubiquitinates XPC IEA Dictyostelium discoideum DDB_G0276765 R-DDI-6783177 https://reactome.org/PathwayBrowser/#/R-DDI-6783177 USP21 deubiquitinates GATA3,IL33 IEA Dictyostelium discoideum DDB_G0276765 R-DDI-6807118 https://reactome.org/PathwayBrowser/#/R-DDI-6807118 USP7 deubiquitinates monoubiquitinated PTEN IEA Dictyostelium discoideum DDB_G0276765 R-DDI-6807134 https://reactome.org/PathwayBrowser/#/R-DDI-6807134 NEDD4, WWP2, CHIP and XIAP polyubiquitinate PTEN IEA Dictyostelium discoideum DDB_G0276765 R-DDI-6807206 https://reactome.org/PathwayBrowser/#/R-DDI-6807206 USP13 and OTUD3 deubiquitinate PTEN IEA Dictyostelium discoideum DDB_G0276765 R-DDI-68946 https://reactome.org/PathwayBrowser/#/R-DDI-68946 Phosphorylated Orc1 is ubiquitinated while still associated with chromatin IEA Dictyostelium discoideum DDB_G0276765 R-DDI-68948 https://reactome.org/PathwayBrowser/#/R-DDI-68948 Ubiquitinated Orc1 is degraded by the proteasome IEA Dictyostelium discoideum DDB_G0276765 R-DDI-69015 https://reactome.org/PathwayBrowser/#/R-DDI-69015 Cytoplasmic phosphorylated Cdc6 is ubiquitinated by the anaphase-promoting complex IEA Dictyostelium discoideum DDB_G0276765 R-DDI-69016 https://reactome.org/PathwayBrowser/#/R-DDI-69016 Ubiquitinated Cdc6 is degraded by the proteasome IEA Dictyostelium discoideum DDB_G0276765 R-DDI-69600 https://reactome.org/PathwayBrowser/#/R-DDI-69600 Proteolytic degradation of ubiquitinated-Cdc25A IEA Dictyostelium discoideum DDB_G0276765 R-DDI-72621 https://reactome.org/PathwayBrowser/#/R-DDI-72621 Ribosomal scanning IEA Dictyostelium discoideum DDB_G0276765 R-DDI-72671 https://reactome.org/PathwayBrowser/#/R-DDI-72671 eIF5B:GTP is hydrolyzed and released IEA Dictyostelium discoideum DDB_G0276765 R-DDI-72672 https://reactome.org/PathwayBrowser/#/R-DDI-72672 The 60S subunit joins the translation initiation complex IEA Dictyostelium discoideum DDB_G0276765 R-DDI-72673 https://reactome.org/PathwayBrowser/#/R-DDI-72673 Release of 40S and 60S subunits from the 80S ribosome IEA Dictyostelium discoideum DDB_G0276765 R-DDI-72676 https://reactome.org/PathwayBrowser/#/R-DDI-72676 eIF3 and eIF1A bind to the 40S subunit IEA Dictyostelium discoideum DDB_G0276765 R-DDI-72691 https://reactome.org/PathwayBrowser/#/R-DDI-72691 Formation of the 43S pre-initiation complex IEA Dictyostelium discoideum DDB_G0276765 R-DDI-72697 https://reactome.org/PathwayBrowser/#/R-DDI-72697 Start codon recognition IEA Dictyostelium discoideum DDB_G0276765 R-DDI-8850992 https://reactome.org/PathwayBrowser/#/R-DDI-8850992 Proteasome degrades polyubiquitinated PTEN IEA Dictyostelium discoideum DDB_G0276765 R-DDI-8852127 https://reactome.org/PathwayBrowser/#/R-DDI-8852127 UBA6 conjugates ubiquitin to cytosolic E2 enzymes IEA Dictyostelium discoideum DDB_G0276765 R-DDI-8852128 https://reactome.org/PathwayBrowser/#/R-DDI-8852128 UBA1 adenylates ubiquitin in the nucleoplasm IEA Dictyostelium discoideum DDB_G0276765 R-DDI-8852129 https://reactome.org/PathwayBrowser/#/R-DDI-8852129 UBA1 conjugates ubiquitin to cytosolic E2 enzymes IEA Dictyostelium discoideum DDB_G0276765 R-DDI-8852130 https://reactome.org/PathwayBrowser/#/R-DDI-8852130 UBA1 conjugates ubiquitin to nuclear E2 enzymes IEA Dictyostelium discoideum DDB_G0276765 R-DDI-8852131 https://reactome.org/PathwayBrowser/#/R-DDI-8852131 Ub-Cys632-UBA1 adenylates ubiquitin in the nucleus IEA Dictyostelium discoideum DDB_G0276765 R-DDI-8852132 https://reactome.org/PathwayBrowser/#/R-DDI-8852132 Ub-Cys632-UBA1 adenylates ubiquitin in the cytosol IEA Dictyostelium discoideum DDB_G0276765 R-DDI-8852133 https://reactome.org/PathwayBrowser/#/R-DDI-8852133 UBA1 conjugates ubiquitin to UBA1 in the cytosol IEA Dictyostelium discoideum DDB_G0276765 R-DDI-8852134 https://reactome.org/PathwayBrowser/#/R-DDI-8852134 UBA1 adenylates ubiquitin in the cytosol IEA Dictyostelium discoideum DDB_G0276765 R-DDI-8852136 https://reactome.org/PathwayBrowser/#/R-DDI-8852136 UBA1 conjugates ubiquitin to UBA1 in the nucleus IEA Dictyostelium discoideum DDB_G0276765 R-DDI-8853379 https://reactome.org/PathwayBrowser/#/R-DDI-8853379 ENGASE hydrolyses unfolded protein:(GlcNAc)2 (Man(9-5) IEA Dictyostelium discoideum DDB_G0276765 R-DDI-8853503 https://reactome.org/PathwayBrowser/#/R-DDI-8853503 UCHL3,USP7,USP9X cleaves RPS27A yielding ubiquitin IEA Dictyostelium discoideum DDB_G0276765 R-DDI-8854041 https://reactome.org/PathwayBrowser/#/R-DDI-8854041 SCF-FBXL7 ubiquitinates AURKA IEA Dictyostelium discoideum DDB_G0276765 R-DDI-8854044 https://reactome.org/PathwayBrowser/#/R-DDI-8854044 Proteasome degrades AURKA ubiquitinated by SCF-FBXL7 IEA Dictyostelium discoideum DDB_G0276765 R-DDI-8866553 https://reactome.org/PathwayBrowser/#/R-DDI-8866553 misfolded CFTR is degraded by the 26S proteasome IEA Dictyostelium discoideum DDB_G0276765 R-DDI-8938770 https://reactome.org/PathwayBrowser/#/R-DDI-8938770 RNF144A binds PRKDC and Ubiquitin:UBE2L3 IEA Dictyostelium discoideum DDB_G0276765 R-DDI-8938773 https://reactome.org/PathwayBrowser/#/R-DDI-8938773 RNF144A polyubiquitinates PRKDC IEA Dictyostelium discoideum DDB_G0276765 R-DDI-8938815 https://reactome.org/PathwayBrowser/#/R-DDI-8938815 RNF152 polyubiquitinates RRAGA IEA Dictyostelium discoideum DDB_G0276765 R-DDI-8938829 https://reactome.org/PathwayBrowser/#/R-DDI-8938829 RNF152 binds RRAGA:GDP and Ubiquitin:UBE2D3 IEA Dictyostelium discoideum DDB_G0276765 R-DDI-8943003 https://reactome.org/PathwayBrowser/#/R-DDI-8943003 SHPRH polyubiquitinates monoubiquitinated PCNA IEA Dictyostelium discoideum DDB_G0276765 R-DDI-8943007 https://reactome.org/PathwayBrowser/#/R-DDI-8943007 SHPRH binds monoUb-K164-PCNA, RAD6:RAD18, UBE2V2:Ub:UBE2N IEA Dictyostelium discoideum DDB_G0276765 R-DDI-8948775 https://reactome.org/PathwayBrowser/#/R-DDI-8948775 MKRN1 polyubiquitinates PTEN IEA Dictyostelium discoideum DDB_G0276765 R-DDI-8953917 https://reactome.org/PathwayBrowser/#/R-DDI-8953917 PEX2:PEX10:PEX12 binds PEX5S,L (in PEX5S:PEX13:PEX14) and Ub:UBE2D1,2,3 IEA Dictyostelium discoideum DDB_G0276765 R-DDI-8953946 https://reactome.org/PathwayBrowser/#/R-DDI-8953946 PEX2:PEX10:PEX12 monoubiquitinates PEX5S,L at cysteine-11 IEA Dictyostelium discoideum DDB_G0276765 R-DDI-9033485 https://reactome.org/PathwayBrowser/#/R-DDI-9033485 PEX2:PEX10:PEX12 monoubiquitinates PEX5L at cysteine-11 IEA Dictyostelium discoideum DDB_G0276765 R-DDI-9033491 https://reactome.org/PathwayBrowser/#/R-DDI-9033491 USP9X hydrolyzes Ub:PEX5L yielding PEX5L and Ubiquitin IEA Dictyostelium discoideum DDB_G0276765 R-DDI-9033509 https://reactome.org/PathwayBrowser/#/R-DDI-9033509 USP9X binds Ub:PEX5L IEA Dictyostelium discoideum DDB_G0276765 R-DDI-9033527 https://reactome.org/PathwayBrowser/#/R-DDI-9033527 PEX2:PEX10:PEX12 binds PEX5L (in PEX5L:PEX7:PEX13:PEX14:PEX2:PEX10:PEX12) and Ub:UBE2D1,2,3 IEA Dictyostelium discoideum DDB_G0276765 R-DDI-917693 https://reactome.org/PathwayBrowser/#/R-DDI-917693 ESCRT Disassembly IEA Dictyostelium discoideum DDB_G0276765 R-DDI-917696 https://reactome.org/PathwayBrowser/#/R-DDI-917696 Cargo Sequestration IEA Dictyostelium discoideum DDB_G0276765 R-DDI-917700 https://reactome.org/PathwayBrowser/#/R-DDI-917700 MVB Vesicle Formation IEA Dictyostelium discoideum DDB_G0276765 R-DDI-927789 https://reactome.org/PathwayBrowser/#/R-DDI-927789 Formation of UPF1:eRF3 complex on mRNA with a premature termination codon and no Exon Junction Complex IEA Dictyostelium discoideum DDB_G0276765 R-DDI-927832 https://reactome.org/PathwayBrowser/#/R-DDI-927832 UPF1 binds an mRNP with a termination codon preceding an Exon Junction Complex IEA Dictyostelium discoideum DDB_G0276765 R-DDI-927889 https://reactome.org/PathwayBrowser/#/R-DDI-927889 SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex) IEA Dictyostelium discoideum DDB_G0276765 R-DDI-936390 https://reactome.org/PathwayBrowser/#/R-DDI-936390 CYLD mediated deubiquitination of DDX58 (RIG-I) IEA Dictyostelium discoideum DDB_G0276765 R-DDI-9641089 https://reactome.org/PathwayBrowser/#/R-DDI-9641089 Parkin binds Ub:UBE2N:UBE2V1 IEA Dictyostelium discoideum DDB_G0276765 R-DDI-9641096 https://reactome.org/PathwayBrowser/#/R-DDI-9641096 Misfolded proteins bind PRKN:UBE2N:UBE2V1:Ub IEA Dictyostelium discoideum DDB_G0276765 R-DDI-9641109 https://reactome.org/PathwayBrowser/#/R-DDI-9641109 PolyUb:misfolded proteins dissociate from PRKN:UBE2N:UBE2V1 IEA Dictyostelium discoideum DDB_G0276765 R-DDI-9641111 https://reactome.org/PathwayBrowser/#/R-DDI-9641111 Parkin transfers Ub to misfolded proteins IEA Dictyostelium discoideum DDB_G0276765 R-DDI-9641127 https://reactome.org/PathwayBrowser/#/R-DDI-9641127 Ub:misfolded proteins polymerize to PolyUb:misfolded proteins IEA Dictyostelium discoideum DDB_G0276765 R-DDI-9646348 https://reactome.org/PathwayBrowser/#/R-DDI-9646348 PolyUb-Misfolded Proteins:HDAC6 bind dynein motor IEA Dictyostelium discoideum DDB_G0276765 R-DDI-9646685 https://reactome.org/PathwayBrowser/#/R-DDI-9646685 Aggresome dissociates from dynein and microtubule IEA Dictyostelium discoideum DDB_G0276765 R-DDI-9664888 https://reactome.org/PathwayBrowser/#/R-DDI-9664888 ATM dimer:p-PEX5 ubiquitinates to form ATM dimer:Ub-p-PEX5 IEA Dictyostelium discoideum DDB_G0276765 R-DDI-9684118 https://reactome.org/PathwayBrowser/#/R-DDI-9684118 ERCC3-facilitated RNA Pol II backtracking in TC-NER IEA Dictyostelium discoideum DDB_G0276765 R-DDI-9686969 https://reactome.org/PathwayBrowser/#/R-DDI-9686969 APC/C:Cdh1 polyubiquitinates SKP2 IEA Dictyostelium discoideum DDB_G0276765 R-DDI-9750942 https://reactome.org/PathwayBrowser/#/R-DDI-9750942 USP14 deubiquitinates NLRC5 IEA Dictyostelium discoideum DDB_G0276765 R-DDI-9755306 https://reactome.org/PathwayBrowser/#/R-DDI-9755306 ub UBXN7 is degraded by the 26S proteasome IEA Dictyostelium discoideum DDB_G0276765 R-DDI-9755505 https://reactome.org/PathwayBrowser/#/R-DDI-9755505 KEAP1:NEDD8-CUL3:RBX1 complex ubiquitinates NFE2L2 IEA Dictyostelium discoideum DDB_G0276765 R-DDI-9759172 https://reactome.org/PathwayBrowser/#/R-DDI-9759172 KEAP1:CUL3:RBX1 ubiquitinates p-S349 SQSTM1 oligomer IEA Dictyostelium discoideum DDB_G0276765 R-DDI-9766645 https://reactome.org/PathwayBrowser/#/R-DDI-9766645 CUL3:RBX1 ubiquitinates KEAP1 IEA Dictyostelium discoideum DDB_G0276765 R-DDI-9793472 https://reactome.org/PathwayBrowser/#/R-DDI-9793472 RIPK3 binds p-S9-PRKN IEA Dictyostelium discoideum DDB_G0276765 R-DDI-9793485 https://reactome.org/PathwayBrowser/#/R-DDI-9793485 PRKN polyubiquitinates RIPK3 IEA Dictyostelium discoideum DDB_G0276765 R-DDI-983140 https://reactome.org/PathwayBrowser/#/R-DDI-983140 Transfer of Ub from E2 to substrate and release of E2 IEA Dictyostelium discoideum DDB_G0276765 R-DDI-983150 https://reactome.org/PathwayBrowser/#/R-DDI-983150 Proteasomal cleavage of substrate IEA Dictyostelium discoideum DDB_G0276765 R-DDI-983152 https://reactome.org/PathwayBrowser/#/R-DDI-983152 Transfer of ubiquitin from E1 to E2 IEA Dictyostelium discoideum DDB_G0276765 R-DDI-983153 https://reactome.org/PathwayBrowser/#/R-DDI-983153 E1 mediated ubiquitin activation IEA Dictyostelium discoideum DDB_G0276765 R-DDI-983156 https://reactome.org/PathwayBrowser/#/R-DDI-983156 Polyubiquitination of substrate IEA Dictyostelium discoideum DDB_G0276765 R-DDI-983157 https://reactome.org/PathwayBrowser/#/R-DDI-983157 Interaction of E3 with substrate and E2-Ub complex IEA Dictyostelium discoideum DDB_G0276765 R-DDI-9861640 https://reactome.org/PathwayBrowser/#/R-DDI-9861640 CTLH E3 ligase ubiquitinates PKM-1 IEA Dictyostelium discoideum DDB_G0276783 R-DDI-430028 https://reactome.org/PathwayBrowser/#/R-DDI-430028 Exosome Complex hydrolyzes mRNA by 3' to 5' exoribonuclease digestion IEA Dictyostelium discoideum DDB_G0276783 R-DDI-450431 https://reactome.org/PathwayBrowser/#/R-DDI-450431 ZFP36 (TTP) recruits RNA degradation activities IEA Dictyostelium discoideum DDB_G0276783 R-DDI-450488 https://reactome.org/PathwayBrowser/#/R-DDI-450488 BRF1 Complex recruits RNA degradation activities IEA Dictyostelium discoideum DDB_G0276783 R-DDI-6791222 https://reactome.org/PathwayBrowser/#/R-DDI-6791222 21S pre-rRNA is nucleolytically processed at site E (site2a) to yield 18SE pre-rRNA IEA Dictyostelium discoideum DDB_G0276799 R-DDI-1227670 https://reactome.org/PathwayBrowser/#/R-DDI-1227670 Recruitment of HDAC1 by p130 (RBL2) IEA Dictyostelium discoideum DDB_G0276799 R-DDI-1227671 https://reactome.org/PathwayBrowser/#/R-DDI-1227671 Recruitment of HDAC1 by p107 (RBL1) IEA Dictyostelium discoideum DDB_G0276799 R-DDI-1363303 https://reactome.org/PathwayBrowser/#/R-DDI-1363303 p130 (RBL2) in complex with E2F4/5:DP1/2 binds to cyclin E/A:CDK2 IEA Dictyostelium discoideum DDB_G0276799 R-DDI-1363311 https://reactome.org/PathwayBrowser/#/R-DDI-1363311 p107 (RBL1) in complex with E2F4:DP1/2 binds to cyclin E/A:CDK2 IEA Dictyostelium discoideum DDB_G0276799 R-DDI-8953111 https://reactome.org/PathwayBrowser/#/R-DDI-8953111 E2F6 binds TFDP1 IEA Dictyostelium discoideum DDB_G0276799 R-DDI-8954056 https://reactome.org/PathwayBrowser/#/R-DDI-8954056 E2F6 binds TFDP2 IEA Dictyostelium discoideum DDB_G0276799 R-DDI-8954117 https://reactome.org/PathwayBrowser/#/R-DDI-8954117 E2F6:TFDP1 binds EPC1 IEA Dictyostelium discoideum DDB_G0276799 R-DDI-9018017 https://reactome.org/PathwayBrowser/#/R-DDI-9018017 RB1 binds and inhibits E2F1/2/3:DP1/2 complexes IEA Dictyostelium discoideum DDB_G0276801 R-DDI-5662662 https://reactome.org/PathwayBrowser/#/R-DDI-5662662 Tyrosinase oxidises tyrosine to dopaquinone IEA Dictyostelium discoideum DDB_G0276801 R-DDI-8875902 https://reactome.org/PathwayBrowser/#/R-DDI-8875902 SLC45A3 transports Glc from extracellular region to cytosol IEA Dictyostelium discoideum DDB_G0276803 R-DDI-6782069 https://reactome.org/PathwayBrowser/#/R-DDI-6782069 UVSSA:USP7 deubiquitinates ERCC6 IEA Dictyostelium discoideum DDB_G0276803 R-DDI-6782131 https://reactome.org/PathwayBrowser/#/R-DDI-6782131 ERCC2-facilitated RNA Pol II backtracking in TC-NER IEA Dictyostelium discoideum DDB_G0276803 R-DDI-6782141 https://reactome.org/PathwayBrowser/#/R-DDI-6782141 Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in TC-NER IEA Dictyostelium discoideum DDB_G0276803 R-DDI-6782204 https://reactome.org/PathwayBrowser/#/R-DDI-6782204 5' incision of damaged DNA strand by ERCC1:ERCC4 in TC-NER IEA Dictyostelium discoideum DDB_G0276803 R-DDI-6782208 https://reactome.org/PathwayBrowser/#/R-DDI-6782208 Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in TC-NER IEA Dictyostelium discoideum DDB_G0276803 R-DDI-6782211 https://reactome.org/PathwayBrowser/#/R-DDI-6782211 DNA polymerases delta, epsilon or kappa bind the TC-NER site IEA Dictyostelium discoideum DDB_G0276803 R-DDI-6782227 https://reactome.org/PathwayBrowser/#/R-DDI-6782227 Ligation of newly synthesized repair patch to incised DNA in TC-NER IEA Dictyostelium discoideum DDB_G0276803 R-DDI-9684118 https://reactome.org/PathwayBrowser/#/R-DDI-9684118 ERCC3-facilitated RNA Pol II backtracking in TC-NER IEA Dictyostelium discoideum DDB_G0276803 R-DDI-9770236 https://reactome.org/PathwayBrowser/#/R-DDI-9770236 Formation of the Spliceosomal P complex and exon ligation IEA Dictyostelium discoideum DDB_G0276815 R-DDI-6791222 https://reactome.org/PathwayBrowser/#/R-DDI-6791222 21S pre-rRNA is nucleolytically processed at site E (site2a) to yield 18SE pre-rRNA IEA Dictyostelium discoideum DDB_G0276815 R-DDI-6791227 https://reactome.org/PathwayBrowser/#/R-DDI-6791227 47S pre-rRNA is nucleolytically processed at A' (01,A1), site A0, and site 02 (site 6) to yield 45S pre-rRNA IEA Dictyostelium discoideum DDB_G0276815 R-DDI-8952638 https://reactome.org/PathwayBrowser/#/R-DDI-8952638 AcM-UBE2M transfers NEDD8 to CRL4 E3 ubiquitin ligase complex IEA Dictyostelium discoideum DDB_G0276815 R-DDI-8952639 https://reactome.org/PathwayBrowser/#/R-DDI-8952639 NEDD8:AcM-UBE2M binds CRL4 E3 ubiquitin ligase complex IEA Dictyostelium discoideum DDB_G0276815 R-DDI-8955245 https://reactome.org/PathwayBrowser/#/R-DDI-8955245 CAND1 binds CRL4 E3 ubiquitin ligase in the nucleus IEA Dictyostelium discoideum DDB_G0276815 R-DDI-8955285 https://reactome.org/PathwayBrowser/#/R-DDI-8955285 COMMDs displace CAND1 from CRL4 E3 ubiquitin ligase complex IEA Dictyostelium discoideum DDB_G0276815 R-DDI-8956045 https://reactome.org/PathwayBrowser/#/R-DDI-8956045 COP9 signalosome deneddylates nuclear CRL4 E3 ubiquitin ligase complex IEA Dictyostelium discoideum DDB_G0276821 R-DDI-6797955 https://reactome.org/PathwayBrowser/#/R-DDI-6797955 ALDH7A1 oxidises BETALD to BET IEA Dictyostelium discoideum DDB_G0276821 R-DDI-70941 https://reactome.org/PathwayBrowser/#/R-DDI-70941 alpha-aminoadipoate semialdehyde + NAD+ => alpha-aminoadipate + NADH + H+ IEA Dictyostelium discoideum DDB_G0276833 R-DDI-9013144 https://reactome.org/PathwayBrowser/#/R-DDI-9013144 RAC1 GAPs stimulate RAC1 GTPase activity IEA Dictyostelium discoideum DDB_G0276833 R-DDI-9013161 https://reactome.org/PathwayBrowser/#/R-DDI-9013161 CDC42 GAPs stimulate CDC42 GTPase activity IEA Dictyostelium discoideum DDB_G0276833 R-DDI-9018794 https://reactome.org/PathwayBrowser/#/R-DDI-9018794 RHOV binds effectors at the plasma membrane IEA Dictyostelium discoideum DDB_G0276833 R-DDI-9018806 https://reactome.org/PathwayBrowser/#/R-DDI-9018806 RAC3 GAPs stimulate RAC3 GTPase activity IEA Dictyostelium discoideum DDB_G0276863 R-DDI-2172678 https://reactome.org/PathwayBrowser/#/R-DDI-2172678 PHF8 demethylates histone H4K20me1 IEA Dictyostelium discoideum DDB_G0276863 R-DDI-2288097 https://reactome.org/PathwayBrowser/#/R-DDI-2288097 Condensin II complex binds H4K20me1-containing nucleosomes IEA Dictyostelium discoideum DDB_G0276863 R-DDI-2294580 https://reactome.org/PathwayBrowser/#/R-DDI-2294580 PLK1 hyperphosphorylates Condensin II complex IEA Dictyostelium discoideum DDB_G0276863 R-DDI-2294590 https://reactome.org/PathwayBrowser/#/R-DDI-2294590 PLK1 binds phosphorylated condensin II complex IEA Dictyostelium discoideum DDB_G0276863 R-DDI-3222593 https://reactome.org/PathwayBrowser/#/R-DDI-3222593 KDM6B demethylates H3K27me3 on p16INK4A promoter IEA Dictyostelium discoideum DDB_G0276863 R-DDI-3662318 https://reactome.org/PathwayBrowser/#/R-DDI-3662318 Type B histone acetlytransferase complex acetylates histone H4 IEA Dictyostelium discoideum DDB_G0276863 R-DDI-3769447 https://reactome.org/PathwayBrowser/#/R-DDI-3769447 HDAC1:2-containing complex deacetylate histones IEA Dictyostelium discoideum DDB_G0276863 R-DDI-3782637 https://reactome.org/PathwayBrowser/#/R-DDI-3782637 HDAC8 deacetylates histones IEA Dictyostelium discoideum DDB_G0276863 R-DDI-3782655 https://reactome.org/PathwayBrowser/#/R-DDI-3782655 HDAC10 deacetylates histone IEA Dictyostelium discoideum DDB_G0276863 R-DDI-427514 https://reactome.org/PathwayBrowser/#/R-DDI-427514 eNoSC deacetylates histone H3 IEA Dictyostelium discoideum DDB_G0276863 R-DDI-427527 https://reactome.org/PathwayBrowser/#/R-DDI-427527 eNoSC dimethylates histone H3 at lysine-9 IEA Dictyostelium discoideum DDB_G0276863 R-DDI-4570485 https://reactome.org/PathwayBrowser/#/R-DDI-4570485 SUMOylation of Histone H4 with SUMO3 IEA Dictyostelium discoideum DDB_G0276863 R-DDI-4570496 https://reactome.org/PathwayBrowser/#/R-DDI-4570496 SUMOylation of Histone H4 with SUMO1 IEA Dictyostelium discoideum DDB_G0276863 R-DDI-5205798 https://reactome.org/PathwayBrowser/#/R-DDI-5205798 PRMT1,PRMT6 methylate arginine-4 of histone H4 IEA Dictyostelium discoideum DDB_G0276863 R-DDI-5625784 https://reactome.org/PathwayBrowser/#/R-DDI-5625784 PKN1 phosphorylates histone 3 of nucleosomes associate with KLK2 and KLK3 promoters IEA Dictyostelium discoideum DDB_G0276863 R-DDI-5661126 https://reactome.org/PathwayBrowser/#/R-DDI-5661126 PRMT1,PRMT6 methylate methyl-lysine-4 of histone H4 IEA Dictyostelium discoideum DDB_G0276863 R-DDI-5682588 https://reactome.org/PathwayBrowser/#/R-DDI-5682588 RNF8 binds phosphorylated MDC1 at DNA DSBs IEA Dictyostelium discoideum DDB_G0276863 R-DDI-5682965 https://reactome.org/PathwayBrowser/#/R-DDI-5682965 WHSC1 dimethylates histone H4 on lysine K21 at DSBs IEA Dictyostelium discoideum DDB_G0276863 R-DDI-5682967 https://reactome.org/PathwayBrowser/#/R-DDI-5682967 WHSC1 binds DNA DSBs IEA Dictyostelium discoideum DDB_G0276863 R-DDI-5682983 https://reactome.org/PathwayBrowser/#/R-DDI-5682983 ATM phosphorylates WHSC1 IEA Dictyostelium discoideum DDB_G0276863 R-DDI-5683405 https://reactome.org/PathwayBrowser/#/R-DDI-5683405 PPP5C dephosphorylates TP53BP1 IEA Dictyostelium discoideum DDB_G0276863 R-DDI-5683425 https://reactome.org/PathwayBrowser/#/R-DDI-5683425 ATM phosphorylates TP53BP1 at DNA DSBs IEA Dictyostelium discoideum DDB_G0276863 R-DDI-5693536 https://reactome.org/PathwayBrowser/#/R-DDI-5693536 ATM phosphorylates MDC1 IEA Dictyostelium discoideum DDB_G0276863 R-DDI-5693549 https://reactome.org/PathwayBrowser/#/R-DDI-5693549 ATM phosphorylates histone H2AFX on S139 at DNA DSBs IEA Dictyostelium discoideum DDB_G0276863 R-DDI-5693566 https://reactome.org/PathwayBrowser/#/R-DDI-5693566 TP53BP1 associates with H4K20Me2 at DNA DSBs IEA Dictyostelium discoideum DDB_G0276863 R-DDI-5693602 https://reactome.org/PathwayBrowser/#/R-DDI-5693602 ATM recognizes H2AFX-Nucleosomes IEA Dictyostelium discoideum DDB_G0276863 R-DDI-74986 https://reactome.org/PathwayBrowser/#/R-DDI-74986 Elongation of pre-rRNA transcript IEA Dictyostelium discoideum DDB_G0276863 R-DDI-9749197 https://reactome.org/PathwayBrowser/#/R-DDI-9749197 ORC1 binds to H4K20me2 IEA Dictyostelium discoideum DDB_G0276863 R-DDI-9843978 https://reactome.org/PathwayBrowser/#/R-DDI-9843978 CBX5 (HP-1alpha) binds TRIM28 (KAP1) in SUMO2-6K-TRIM28:KRAB-ZFP:retroelement chromatin IEA Dictyostelium discoideum DDB_G0276871 R-DDI-156826 https://reactome.org/PathwayBrowser/#/R-DDI-156826 Dissociation of L13a from the 60s ribosomal subunit IEA Dictyostelium discoideum DDB_G0276871 R-DDI-1799332 https://reactome.org/PathwayBrowser/#/R-DDI-1799332 Nascent polypeptide:mRNA:ribosome complex binds signal recognition particle (SRP) IEA Dictyostelium discoideum DDB_G0276871 R-DDI-72671 https://reactome.org/PathwayBrowser/#/R-DDI-72671 eIF5B:GTP is hydrolyzed and released IEA Dictyostelium discoideum DDB_G0276871 R-DDI-72672 https://reactome.org/PathwayBrowser/#/R-DDI-72672 The 60S subunit joins the translation initiation complex IEA Dictyostelium discoideum DDB_G0276871 R-DDI-72673 https://reactome.org/PathwayBrowser/#/R-DDI-72673 Release of 40S and 60S subunits from the 80S ribosome IEA Dictyostelium discoideum DDB_G0276871 R-DDI-927789 https://reactome.org/PathwayBrowser/#/R-DDI-927789 Formation of UPF1:eRF3 complex on mRNA with a premature termination codon and no Exon Junction Complex IEA Dictyostelium discoideum DDB_G0276871 R-DDI-927832 https://reactome.org/PathwayBrowser/#/R-DDI-927832 UPF1 binds an mRNP with a termination codon preceding an Exon Junction Complex IEA Dictyostelium discoideum DDB_G0276871 R-DDI-927889 https://reactome.org/PathwayBrowser/#/R-DDI-927889 SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex) IEA Dictyostelium discoideum DDB_G0276883 R-DDI-2730867 https://reactome.org/PathwayBrowser/#/R-DDI-2730867 Translocation of CaN:CaM:NFAT to nucleus IEA Dictyostelium discoideum DDB_G0276883 R-DDI-2730872 https://reactome.org/PathwayBrowser/#/R-DDI-2730872 Activation of Calcineurin IEA Dictyostelium discoideum DDB_G0276883 R-DDI-4551465 https://reactome.org/PathwayBrowser/#/R-DDI-4551465 Translocation of NFATC1:CaN:CaM to nucleus IEA Dictyostelium discoideum DDB_G0276885 R-DDI-2529020 https://reactome.org/PathwayBrowser/#/R-DDI-2529020 CK2 phosphorylates condensin I subunits IEA Dictyostelium discoideum DDB_G0276885 R-DDI-6805061 https://reactome.org/PathwayBrowser/#/R-DDI-6805061 CK2 binds FACT IEA Dictyostelium discoideum DDB_G0276885 R-DDI-8850945 https://reactome.org/PathwayBrowser/#/R-DDI-8850945 Casein kinase II phosphorylates PTEN IEA Dictyostelium discoideum DDB_G0276885 R-DDI-8948039 https://reactome.org/PathwayBrowser/#/R-DDI-8948039 FUNDC1 is phosphorylated by CK2 IEA Dictyostelium discoideum DDB_G0276913 R-DDI-9603775 https://reactome.org/PathwayBrowser/#/R-DDI-9603775 PEX3:PEX19:class I PMP dissociates IEA Dictyostelium discoideum DDB_G0276913 R-DDI-9603784 https://reactome.org/PathwayBrowser/#/R-DDI-9603784 PEX19:class I PMP binds PEX3 IEA Dictyostelium discoideum DDB_G0276913 R-DDI-9603804 https://reactome.org/PathwayBrowser/#/R-DDI-9603804 PEX19 binds class I peroxisomal membrane proteins IEA Dictyostelium discoideum DDB_G0276917 R-DDI-1236970 https://reactome.org/PathwayBrowser/#/R-DDI-1236970 Proteasomal clevage of exogenous antigen (26S proteasome catalyst) IEA Dictyostelium discoideum DDB_G0276917 R-DDI-1504193 https://reactome.org/PathwayBrowser/#/R-DDI-1504193 Ubiquitinated DVL is degraded by the proteasome IEA Dictyostelium discoideum DDB_G0276917 R-DDI-174058 https://reactome.org/PathwayBrowser/#/R-DDI-174058 Degradation of multiubiquitinated Cdh1 IEA Dictyostelium discoideum DDB_G0276917 R-DDI-174105 https://reactome.org/PathwayBrowser/#/R-DDI-174105 Degradation of multiubiquitinated cell cycle proteins IEA Dictyostelium discoideum DDB_G0276917 R-DDI-174202 https://reactome.org/PathwayBrowser/#/R-DDI-174202 Degradation of multiubiquitinated Securin IEA Dictyostelium discoideum DDB_G0276917 R-DDI-188191 https://reactome.org/PathwayBrowser/#/R-DDI-188191 APC/C:Cdh1-mediated degradation of Skp2 IEA Dictyostelium discoideum DDB_G0276917 R-DDI-264458 https://reactome.org/PathwayBrowser/#/R-DDI-264458 Proteasome mediated degradation of COP1 IEA Dictyostelium discoideum DDB_G0276917 R-DDI-450466 https://reactome.org/PathwayBrowser/#/R-DDI-450466 AUF1:mRNA complex is destroyed IEA Dictyostelium discoideum DDB_G0276917 R-DDI-5635854 https://reactome.org/PathwayBrowser/#/R-DDI-5635854 GLI2,3 are degraded by the proteasome IEA Dictyostelium discoideum DDB_G0276917 R-DDI-5658430 https://reactome.org/PathwayBrowser/#/R-DDI-5658430 NF1 is degraded by the proteasome IEA Dictyostelium discoideum DDB_G0276917 R-DDI-5665854 https://reactome.org/PathwayBrowser/#/R-DDI-5665854 ADRM1:26S proteaseome binds UCHL5 IEA Dictyostelium discoideum DDB_G0276917 R-DDI-5665871 https://reactome.org/PathwayBrowser/#/R-DDI-5665871 ADRM1 binds 26S proteasome IEA Dictyostelium discoideum DDB_G0276917 R-DDI-5687112 https://reactome.org/PathwayBrowser/#/R-DDI-5687112 MAPK6 is degraded by the 26S proteasome IEA Dictyostelium discoideum DDB_G0276917 R-DDI-5689539 https://reactome.org/PathwayBrowser/#/R-DDI-5689539 ADRM1:26S proteaseome binds USP14 IEA Dictyostelium discoideum DDB_G0276917 R-DDI-6798748 https://reactome.org/PathwayBrowser/#/R-DDI-6798748 Exocytosis of secretory granule lumen proteins IEA Dictyostelium discoideum DDB_G0276917 R-DDI-6800434 https://reactome.org/PathwayBrowser/#/R-DDI-6800434 Exocytosis of ficolin-rich granule lumen proteins IEA Dictyostelium discoideum DDB_G0276917 R-DDI-68948 https://reactome.org/PathwayBrowser/#/R-DDI-68948 Ubiquitinated Orc1 is degraded by the proteasome IEA Dictyostelium discoideum DDB_G0276917 R-DDI-69016 https://reactome.org/PathwayBrowser/#/R-DDI-69016 Ubiquitinated Cdc6 is degraded by the proteasome IEA Dictyostelium discoideum DDB_G0276917 R-DDI-69600 https://reactome.org/PathwayBrowser/#/R-DDI-69600 Proteolytic degradation of ubiquitinated-Cdc25A IEA Dictyostelium discoideum DDB_G0276917 R-DDI-8850992 https://reactome.org/PathwayBrowser/#/R-DDI-8850992 Proteasome degrades polyubiquitinated PTEN IEA Dictyostelium discoideum DDB_G0276917 R-DDI-8854044 https://reactome.org/PathwayBrowser/#/R-DDI-8854044 Proteasome degrades AURKA ubiquitinated by SCF-FBXL7 IEA Dictyostelium discoideum DDB_G0276917 R-DDI-8866553 https://reactome.org/PathwayBrowser/#/R-DDI-8866553 misfolded CFTR is degraded by the 26S proteasome IEA Dictyostelium discoideum DDB_G0276917 R-DDI-9755306 https://reactome.org/PathwayBrowser/#/R-DDI-9755306 ub UBXN7 is degraded by the 26S proteasome IEA Dictyostelium discoideum DDB_G0276917 R-DDI-983150 https://reactome.org/PathwayBrowser/#/R-DDI-983150 Proteasomal cleavage of substrate IEA Dictyostelium discoideum DDB_G0276917 R-DDI-9907954 https://reactome.org/PathwayBrowser/#/R-DDI-9907954 PSMC2 binds PSMC1 IEA Dictyostelium discoideum DDB_G0276917 R-DDI-9907976 https://reactome.org/PathwayBrowser/#/R-DDI-9907976 PSMD5 and PSMD2 bind PSMC2:PSMC1 IEA Dictyostelium discoideum DDB_G0276917 R-DDI-9907980 https://reactome.org/PathwayBrowser/#/R-DDI-9907980 Formation of the 19S regulatory particle base precursor IEA Dictyostelium discoideum DDB_G0276917 R-DDI-9908026 https://reactome.org/PathwayBrowser/#/R-DDI-9908026 Formation of the 19S regulatory particle precursor IEA Dictyostelium discoideum DDB_G0276917 R-DDI-9908178 https://reactome.org/PathwayBrowser/#/R-DDI-9908178 Formation of the 26S proteasome IEA Dictyostelium discoideum DDB_G0276919 R-DDI-8940388 https://reactome.org/PathwayBrowser/#/R-DDI-8940388 GPLD1 hydrolyses GPI-anchors from proteins IEA Dictyostelium discoideum DDB_G0276935 R-DDI-204008 https://reactome.org/PathwayBrowser/#/R-DDI-204008 SEC31:SEC13 and v-SNARE recruitment IEA Dictyostelium discoideum DDB_G0276935 R-DDI-5694409 https://reactome.org/PathwayBrowser/#/R-DDI-5694409 Nucleotide exchange on RAB1 IEA Dictyostelium discoideum DDB_G0276935 R-DDI-5694439 https://reactome.org/PathwayBrowser/#/R-DDI-5694439 COPII coat binds TRAPPCII and RAB1:GDP IEA Dictyostelium discoideum DDB_G0276935 R-DDI-5694441 https://reactome.org/PathwayBrowser/#/R-DDI-5694441 CSNK1D phosphorylates SEC23 IEA Dictyostelium discoideum DDB_G0276935 R-DDI-6786650 https://reactome.org/PathwayBrowser/#/R-DDI-6786650 DDHD1,2 hydrolyse PA IEA Dictyostelium discoideum DDB_G0276935 R-DDI-8869241 https://reactome.org/PathwayBrowser/#/R-DDI-8869241 PITPNM1,2,3 exchange PI for PA IEA Dictyostelium discoideum DDB_G0276945 R-DDI-5229111 https://reactome.org/PathwayBrowser/#/R-DDI-5229111 AP4 transports APP from trans-Golgi network to endosome lumen IEA Dictyostelium discoideum DDB_G0276947 R-DDI-70994 https://reactome.org/PathwayBrowser/#/R-DDI-70994 SDH complex dehydrogenates succinate IEA Dictyostelium discoideum DDB_G0276961 R-DDI-6800426 https://reactome.org/PathwayBrowser/#/R-DDI-6800426 Exocytosis of ficolin-rich granule membrane proteins IEA Dictyostelium discoideum DDB_G0276961 R-DDI-8854173 https://reactome.org/PathwayBrowser/#/R-DDI-8854173 TBC RabGAPs accelerate GTP hydrolysis by RAB35 IEA Dictyostelium discoideum DDB_G0276961 R-DDI-8854209 https://reactome.org/PathwayBrowser/#/R-DDI-8854209 TBC1D10A binds JFC1 IEA Dictyostelium discoideum DDB_G0276963 R-DDI-205039 https://reactome.org/PathwayBrowser/#/R-DDI-205039 p75NTR indirectly activates RAC and Cdc42 via a guanyl-nucleotide exchange factor IEA Dictyostelium discoideum DDB_G0276963 R-DDI-9013143 https://reactome.org/PathwayBrowser/#/R-DDI-9013143 RAC1 GEFs activate RAC1 IEA Dictyostelium discoideum DDB_G0276963 R-DDI-9013159 https://reactome.org/PathwayBrowser/#/R-DDI-9013159 CDC42 GEFs activate CDC42 IEA Dictyostelium discoideum DDB_G0276967 R-DDI-6798743 https://reactome.org/PathwayBrowser/#/R-DDI-6798743 Exocytosis of secretory granule membrane proteins IEA Dictyostelium discoideum DDB_G0276967 R-DDI-9014293 https://reactome.org/PathwayBrowser/#/R-DDI-9014293 RAC2 GDIs block activation of RAC2 IEA Dictyostelium discoideum DDB_G0276967 R-DDI-9014294 https://reactome.org/PathwayBrowser/#/R-DDI-9014294 RAC2 binds effectors at the plasma membrane IEA Dictyostelium discoideum DDB_G0276967 R-DDI-9014295 https://reactome.org/PathwayBrowser/#/R-DDI-9014295 RAC2 GAPs stimulate RAC2 GTPase activity IEA Dictyostelium discoideum DDB_G0276967 R-DDI-9014296 https://reactome.org/PathwayBrowser/#/R-DDI-9014296 RAC2 GEFs activate RAC2 IEA Dictyostelium discoideum DDB_G0276967 R-DDI-9014420 https://reactome.org/PathwayBrowser/#/R-DDI-9014420 RAC2 translocates to the phagocytic vesicle membrane IEA Dictyostelium discoideum DDB_G0276967 R-DDI-9014433 https://reactome.org/PathwayBrowser/#/R-DDI-9014433 RHOG GEFs activate RHOG IEA Dictyostelium discoideum DDB_G0276967 R-DDI-9014449 https://reactome.org/PathwayBrowser/#/R-DDI-9014449 RHOG binds effectors at the plasma membrane IEA Dictyostelium discoideum DDB_G0276967 R-DDI-9014454 https://reactome.org/PathwayBrowser/#/R-DDI-9014454 RHOG translocates to the ER membrane IEA Dictyostelium discoideum DDB_G0276967 R-DDI-9014456 https://reactome.org/PathwayBrowser/#/R-DDI-9014456 GDIs block activation of RHOG IEA Dictyostelium discoideum DDB_G0276967 R-DDI-9018754 https://reactome.org/PathwayBrowser/#/R-DDI-9018754 GDIs bind RHOH IEA Dictyostelium discoideum DDB_G0276967 R-DDI-9018756 https://reactome.org/PathwayBrowser/#/R-DDI-9018756 RHOH binds GTP IEA Dictyostelium discoideum DDB_G0276967 R-DDI-9018758 https://reactome.org/PathwayBrowser/#/R-DDI-9018758 RHOH binds effectors at the plasma membrane IEA Dictyostelium discoideum DDB_G0276967 R-DDI-9018774 https://reactome.org/PathwayBrowser/#/R-DDI-9018774 RHOBTB1 binds GTP IEA Dictyostelium discoideum DDB_G0276967 R-DDI-9018778 https://reactome.org/PathwayBrowser/#/R-DDI-9018778 RHOBTB1 binds interacting proteins at the endosome membrane IEA Dictyostelium discoideum DDB_G0276967 R-DDI-9018787 https://reactome.org/PathwayBrowser/#/R-DDI-9018787 RHOBTB2 binds interacting proteins at the endosome membrane IEA Dictyostelium discoideum DDB_G0276967 R-DDI-9714477 https://reactome.org/PathwayBrowser/#/R-DDI-9714477 RAC2 binds effectors at the mitochondrial outer membrane IEA Dictyostelium discoideum DDB_G0276967 R-DDI-9714480 https://reactome.org/PathwayBrowser/#/R-DDI-9714480 RAC2 translocates to the mitochondrial membrane IEA Dictyostelium discoideum DDB_G0276967 R-DDI-9714483 https://reactome.org/PathwayBrowser/#/R-DDI-9714483 RAC2 translocates to the ER membrane IEA Dictyostelium discoideum DDB_G0276969 R-DDI-372519 https://reactome.org/PathwayBrowser/#/R-DDI-372519 AcCho is hydrolyzed to Cho and acetate by ACHE IEA Dictyostelium discoideum DDB_G0276969 R-DDI-5693691 https://reactome.org/PathwayBrowser/#/R-DDI-5693691 CES1 trimer.CES2 hydrolyse COCN to BEG IEA Dictyostelium discoideum DDB_G0276969 R-DDI-9619024 https://reactome.org/PathwayBrowser/#/R-DDI-9619024 CES1 trimer hydrolyses ACEI pro-drugs to ACEIs IEA Dictyostelium discoideum DDB_G0276969 R-DDI-9634834 https://reactome.org/PathwayBrowser/#/R-DDI-9634834 ACHEIs bind ACHE IEA Dictyostelium discoideum DDB_G0276969 R-DDI-9727567 https://reactome.org/PathwayBrowser/#/R-DDI-9727567 CES1 hydrolyses sacubitril to sacubitrilat IEA Dictyostelium discoideum DDB_G0276969 R-DDI-9749647 https://reactome.org/PathwayBrowser/#/R-DDI-9749647 CES2 hydrolyzes ASA- IEA Dictyostelium discoideum DDB_G0276969 R-DDI-9749792 https://reactome.org/PathwayBrowser/#/R-DDI-9749792 CES1,CES2 hydrolyze ASA- to ST IEA Dictyostelium discoideum DDB_G0276973 R-DDI-435171 https://reactome.org/PathwayBrowser/#/R-DDI-435171 NRAMP1 transports divalent metal ions across phagosomal membranes of macrophages IEA Dictyostelium discoideum DDB_G0276973 R-DDI-435349 https://reactome.org/PathwayBrowser/#/R-DDI-435349 SLC11A2 cotransports Fe2+, H+ from extracellular region to cytosol IEA Dictyostelium discoideum DDB_G0276973 R-DDI-6798747 https://reactome.org/PathwayBrowser/#/R-DDI-6798747 Exocytosis of tertiary granule membrane proteins IEA Dictyostelium discoideum DDB_G0276973 R-DDI-6800426 https://reactome.org/PathwayBrowser/#/R-DDI-6800426 Exocytosis of ficolin-rich granule membrane proteins IEA Dictyostelium discoideum DDB_G0276977 R-DDI-2466068 https://reactome.org/PathwayBrowser/#/R-DDI-2466068 Phosphorylation of cohesin by PLK1 at chromosomal arms IEA Dictyostelium discoideum DDB_G0276977 R-DDI-2468039 https://reactome.org/PathwayBrowser/#/R-DDI-2468039 Acetylation of SMC3 subunit of chromosomal arm associated cohesin by ESCO1 or ESCO2 IEA Dictyostelium discoideum DDB_G0276977 R-DDI-2470935 https://reactome.org/PathwayBrowser/#/R-DDI-2470935 Cohesin binding to decondensed chromatin is facilitated by NIPBL:MAU2 IEA Dictyostelium discoideum DDB_G0276977 R-DDI-2473152 https://reactome.org/PathwayBrowser/#/R-DDI-2473152 Acetylation of SMC3 subunit of centromeric chromatin associated cohesin by ESCO1 or ESCO2 IEA Dictyostelium discoideum DDB_G0276977 R-DDI-2545253 https://reactome.org/PathwayBrowser/#/R-DDI-2545253 Deacetylation of cohesin IEA Dictyostelium discoideum DDB_G0276977 R-DDI-3108212 https://reactome.org/PathwayBrowser/#/R-DDI-3108212 SMC5-SMC6 Complex SUMOylates Cohesin with SUMO1 IEA Dictyostelium discoideum DDB_G0277001 R-DDI-6798745 https://reactome.org/PathwayBrowser/#/R-DDI-6798745 Exocytosis of tertiary granule lumen proteins IEA Dictyostelium discoideum DDB_G0277001 R-DDI-6798748 https://reactome.org/PathwayBrowser/#/R-DDI-6798748 Exocytosis of secretory granule lumen proteins IEA Dictyostelium discoideum DDB_G0277001 R-DDI-6800434 https://reactome.org/PathwayBrowser/#/R-DDI-6800434 Exocytosis of ficolin-rich granule lumen proteins IEA Dictyostelium discoideum DDB_G0277007 R-DDI-742345 https://reactome.org/PathwayBrowser/#/R-DDI-742345 SLC35C1 transport UDP-Fuc from cytosol to Golgi lumen IEA Dictyostelium discoideum DDB_G0277011 R-DDI-8952630 https://reactome.org/PathwayBrowser/#/R-DDI-8952630 NEDD8:AcM-UBE2M binds CRL3 E3 ubiquitin ligase complex IEA Dictyostelium discoideum DDB_G0277011 R-DDI-8952631 https://reactome.org/PathwayBrowser/#/R-DDI-8952631 AcM-UBE2M transfers NEDD8 to CRL3 E3 ubiquitin ligase complex IEA Dictyostelium discoideum DDB_G0277011 R-DDI-8955241 https://reactome.org/PathwayBrowser/#/R-DDI-8955241 CAND1 binds cytosolic CRL E3 ubiquitin ligases IEA Dictyostelium discoideum DDB_G0277011 R-DDI-8955289 https://reactome.org/PathwayBrowser/#/R-DDI-8955289 COMMDs displace CAND1 from cytosolic CRL E3 ubiquitin ligase complexes IEA Dictyostelium discoideum DDB_G0277011 R-DDI-8956040 https://reactome.org/PathwayBrowser/#/R-DDI-8956040 COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes IEA Dictyostelium discoideum DDB_G0277011 R-DDI-983140 https://reactome.org/PathwayBrowser/#/R-DDI-983140 Transfer of Ub from E2 to substrate and release of E2 IEA Dictyostelium discoideum DDB_G0277011 R-DDI-983147 https://reactome.org/PathwayBrowser/#/R-DDI-983147 Release of E3 from polyubiquitinated substrate IEA Dictyostelium discoideum DDB_G0277011 R-DDI-983156 https://reactome.org/PathwayBrowser/#/R-DDI-983156 Polyubiquitination of substrate IEA Dictyostelium discoideum DDB_G0277011 R-DDI-983157 https://reactome.org/PathwayBrowser/#/R-DDI-983157 Interaction of E3 with substrate and E2-Ub complex IEA Dictyostelium discoideum DDB_G0277017 R-DDI-205039 https://reactome.org/PathwayBrowser/#/R-DDI-205039 p75NTR indirectly activates RAC and Cdc42 via a guanyl-nucleotide exchange factor IEA Dictyostelium discoideum DDB_G0277017 R-DDI-9013143 https://reactome.org/PathwayBrowser/#/R-DDI-9013143 RAC1 GEFs activate RAC1 IEA Dictyostelium discoideum DDB_G0277019 R-DDI-6791222 https://reactome.org/PathwayBrowser/#/R-DDI-6791222 21S pre-rRNA is nucleolytically processed at site E (site2a) to yield 18SE pre-rRNA IEA Dictyostelium discoideum DDB_G0277019 R-DDI-6791227 https://reactome.org/PathwayBrowser/#/R-DDI-6791227 47S pre-rRNA is nucleolytically processed at A' (01,A1), site A0, and site 02 (site 6) to yield 45S pre-rRNA IEA Dictyostelium discoideum DDB_G0277033 R-DDI-3215448 https://reactome.org/PathwayBrowser/#/R-DDI-3215448 SWI/SNF chromatin remodelling complex enhances MEP50:PRMT5 methyltransferase activity IEA Dictyostelium discoideum DDB_G0277033 R-DDI-5205799 https://reactome.org/PathwayBrowser/#/R-DDI-5205799 CCND1:CDK4:PRMT5:pT5-WDR77 methylates arginine-9 of histone H3 (H3R8) IEA Dictyostelium discoideum DDB_G0277041 R-DDI-165195 https://reactome.org/PathwayBrowser/#/R-DDI-165195 GTP loading by Rheb IEA Dictyostelium discoideum DDB_G0277041 R-DDI-165680 https://reactome.org/PathwayBrowser/#/R-DDI-165680 Formation of active mTORC1 complex IEA Dictyostelium discoideum DDB_G0277041 R-DDI-165692 https://reactome.org/PathwayBrowser/#/R-DDI-165692 Phosphorylation of 4E-BP1 by activated mTORC1 IEA Dictyostelium discoideum DDB_G0277041 R-DDI-165718 https://reactome.org/PathwayBrowser/#/R-DDI-165718 mTORC1 phosphorylation of RPS6KB1 (S6K) IEA Dictyostelium discoideum DDB_G0277041 R-DDI-377186 https://reactome.org/PathwayBrowser/#/R-DDI-377186 Activated Akt1 phosphorylates AKT1S1 (PRAS40) IEA Dictyostelium discoideum DDB_G0277041 R-DDI-380979 https://reactome.org/PathwayBrowser/#/R-DDI-380979 RHEB in mTORC1:RHEB:GTP hydrolyses GTP IEA Dictyostelium discoideum DDB_G0277041 R-DDI-447074 https://reactome.org/PathwayBrowser/#/R-DDI-447074 AMPK phosphorylates Raptor in the mTORC1 complex IEA Dictyostelium discoideum DDB_G0277041 R-DDI-5672010 https://reactome.org/PathwayBrowser/#/R-DDI-5672010 Active MTORC1 phosphorylates ULK1 IEA Dictyostelium discoideum DDB_G0277041 R-DDI-5672017 https://reactome.org/PathwayBrowser/#/R-DDI-5672017 Rheb in the MTORC1 complex hydrolyses GTP IEA Dictyostelium discoideum DDB_G0277041 R-DDI-5672817 https://reactome.org/PathwayBrowser/#/R-DDI-5672817 Active MTORC1 binds the ULK1 complex IEA Dictyostelium discoideum DDB_G0277041 R-DDI-5672828 https://reactome.org/PathwayBrowser/#/R-DDI-5672828 mTORC1 phosphorylates AKT1S1 IEA Dictyostelium discoideum DDB_G0277041 R-DDI-5673768 https://reactome.org/PathwayBrowser/#/R-DDI-5673768 p-AMPK:AMP phosphorylates Raptor in the MTORC1 complex IEA Dictyostelium discoideum DDB_G0277041 R-DDI-5675790 https://reactome.org/PathwayBrowser/#/R-DDI-5675790 MTORC1 dissociates from ULK complex IEA Dictyostelium discoideum DDB_G0277041 R-DDI-8944454 https://reactome.org/PathwayBrowser/#/R-DDI-8944454 mTORC1 phosphorylates MAF1 IEA Dictyostelium discoideum DDB_G0277041 R-DDI-8944457 https://reactome.org/PathwayBrowser/#/R-DDI-8944457 MAF1 translocates to the nucleus IEA Dictyostelium discoideum DDB_G0277041 R-DDI-9640195 https://reactome.org/PathwayBrowser/#/R-DDI-9640195 RRAGA,B hydrolyzes GTP IEA Dictyostelium discoideum DDB_G0277041 R-DDI-9646468 https://reactome.org/PathwayBrowser/#/R-DDI-9646468 mTORC1 binds RHEB:GTP IEA Dictyostelium discoideum DDB_G0277047 R-DDI-8852127 https://reactome.org/PathwayBrowser/#/R-DDI-8852127 UBA6 conjugates ubiquitin to cytosolic E2 enzymes IEA Dictyostelium discoideum DDB_G0277047 R-DDI-983152 https://reactome.org/PathwayBrowser/#/R-DDI-983152 Transfer of ubiquitin from E1 to E2 IEA Dictyostelium discoideum DDB_G0277047 R-DDI-983153 https://reactome.org/PathwayBrowser/#/R-DDI-983153 E1 mediated ubiquitin activation IEA Dictyostelium discoideum DDB_G0277053 R-DDI-1358789 https://reactome.org/PathwayBrowser/#/R-DDI-1358789 Self-ubiquitination of RNF41 IEA Dictyostelium discoideum DDB_G0277053 R-DDI-1358795 https://reactome.org/PathwayBrowser/#/R-DDI-1358795 Deubiquitination of RNF41 by P-USP8 IEA Dictyostelium discoideum DDB_G0277053 R-DDI-1358797 https://reactome.org/PathwayBrowser/#/R-DDI-1358797 Ubiquitinated RNF41 binds P-USP8 IEA Dictyostelium discoideum DDB_G0277053 R-DDI-983140 https://reactome.org/PathwayBrowser/#/R-DDI-983140 Transfer of Ub from E2 to substrate and release of E2 IEA Dictyostelium discoideum DDB_G0277053 R-DDI-983147 https://reactome.org/PathwayBrowser/#/R-DDI-983147 Release of E3 from polyubiquitinated substrate IEA Dictyostelium discoideum DDB_G0277053 R-DDI-983156 https://reactome.org/PathwayBrowser/#/R-DDI-983156 Polyubiquitination of substrate IEA Dictyostelium discoideum DDB_G0277053 R-DDI-983157 https://reactome.org/PathwayBrowser/#/R-DDI-983157 Interaction of E3 with substrate and E2-Ub complex IEA Dictyostelium discoideum DDB_G0277061 R-DDI-5358494 https://reactome.org/PathwayBrowser/#/R-DDI-5358494 DPH2 transfers a 3-amino-3-carboxypropyl group from AdoMet to residue 715 of nascent EEF2 IEA Dictyostelium discoideum DDB_G0277075 R-DDI-983140 https://reactome.org/PathwayBrowser/#/R-DDI-983140 Transfer of Ub from E2 to substrate and release of E2 IEA Dictyostelium discoideum DDB_G0277075 R-DDI-983147 https://reactome.org/PathwayBrowser/#/R-DDI-983147 Release of E3 from polyubiquitinated substrate IEA Dictyostelium discoideum DDB_G0277075 R-DDI-983156 https://reactome.org/PathwayBrowser/#/R-DDI-983156 Polyubiquitination of substrate IEA Dictyostelium discoideum DDB_G0277075 R-DDI-983157 https://reactome.org/PathwayBrowser/#/R-DDI-983157 Interaction of E3 with substrate and E2-Ub complex IEA Dictyostelium discoideum DDB_G0277079 R-DDI-198824 https://reactome.org/PathwayBrowser/#/R-DDI-198824 CYB5R3:FAD reduces CYB5A:ferriheme to CYB5A:heme IEA Dictyostelium discoideum DDB_G0277079 R-DDI-198845 https://reactome.org/PathwayBrowser/#/R-DDI-198845 CYB5A:heme reduces Asc.- to AscH- IEA Dictyostelium discoideum DDB_G0277079 R-DDI-428259 https://reactome.org/PathwayBrowser/#/R-DDI-428259 DEGS1 dehydrogenates dihydroceramide IEA Dictyostelium discoideum DDB_G0277079 R-DDI-428260 https://reactome.org/PathwayBrowser/#/R-DDI-428260 DEGS2 oxygenates dihydroceramide IEA Dictyostelium discoideum DDB_G0277079 R-DDI-5693761 https://reactome.org/PathwayBrowser/#/R-DDI-5693761 FA2H hydroxylates 1,2-saturated fatty acids IEA Dictyostelium discoideum DDB_G0277079 R-DDI-8936442 https://reactome.org/PathwayBrowser/#/R-DDI-8936442 MARC1,MARC2 reduce N-hydroxylated compounds IEA Dictyostelium discoideum DDB_G0277079 R-DDI-9609921 https://reactome.org/PathwayBrowser/#/R-DDI-9609921 SGTA binds Tail-anchored protein IEA Dictyostelium discoideum DDB_G0277087 R-DDI-73797 https://reactome.org/PathwayBrowser/#/R-DDI-73797 FAICAR => IMP + H2O IEA Dictyostelium discoideum DDB_G0277087 R-DDI-73798 https://reactome.org/PathwayBrowser/#/R-DDI-73798 AICAR + 10-Formyl-THF => FAICAR + THF IEA Dictyostelium discoideum DDB_G0277089 R-DDI-8952039 https://reactome.org/PathwayBrowser/#/R-DDI-8952039 NEDD8:AcM-UBE2F binds CRL5 E3 ubiquitin ligase complex IEA Dictyostelium discoideum DDB_G0277089 R-DDI-8952044 https://reactome.org/PathwayBrowser/#/R-DDI-8952044 AcM-UBE2F transfers NEDD8 to CRL5 E3 ubiquitin ligase complex IEA Dictyostelium discoideum DDB_G0277089 R-DDI-8952618 https://reactome.org/PathwayBrowser/#/R-DDI-8952618 AcM-UBE2M transfers NEDD8 to CRL1 E3 ubiquitin ligase complex IEA Dictyostelium discoideum DDB_G0277089 R-DDI-8952620 https://reactome.org/PathwayBrowser/#/R-DDI-8952620 NEDD8:AcM-UBE2M binds CRL1 E3 ubiquitin ligase complex IEA Dictyostelium discoideum DDB_G0277089 R-DDI-8952626 https://reactome.org/PathwayBrowser/#/R-DDI-8952626 AcM-UBE2M transfers NEDD8 to CRL2 E3 ubiquitin ligase complex IEA Dictyostelium discoideum DDB_G0277089 R-DDI-8952630 https://reactome.org/PathwayBrowser/#/R-DDI-8952630 NEDD8:AcM-UBE2M binds CRL3 E3 ubiquitin ligase complex IEA Dictyostelium discoideum DDB_G0277089 R-DDI-8952631 https://reactome.org/PathwayBrowser/#/R-DDI-8952631 AcM-UBE2M transfers NEDD8 to CRL3 E3 ubiquitin ligase complex IEA Dictyostelium discoideum DDB_G0277089 R-DDI-8952638 https://reactome.org/PathwayBrowser/#/R-DDI-8952638 AcM-UBE2M transfers NEDD8 to CRL4 E3 ubiquitin ligase complex IEA Dictyostelium discoideum DDB_G0277089 R-DDI-8952639 https://reactome.org/PathwayBrowser/#/R-DDI-8952639 NEDD8:AcM-UBE2M binds CRL4 E3 ubiquitin ligase complex IEA Dictyostelium discoideum DDB_G0277089 R-DDI-8955285 https://reactome.org/PathwayBrowser/#/R-DDI-8955285 COMMDs displace CAND1 from CRL4 E3 ubiquitin ligase complex IEA Dictyostelium discoideum DDB_G0277089 R-DDI-8955289 https://reactome.org/PathwayBrowser/#/R-DDI-8955289 COMMDs displace CAND1 from cytosolic CRL E3 ubiquitin ligase complexes IEA Dictyostelium discoideum DDB_G0277089 R-DDI-8956040 https://reactome.org/PathwayBrowser/#/R-DDI-8956040 COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes IEA Dictyostelium discoideum DDB_G0277089 R-DDI-8956045 https://reactome.org/PathwayBrowser/#/R-DDI-8956045 COP9 signalosome deneddylates nuclear CRL4 E3 ubiquitin ligase complex IEA Dictyostelium discoideum DDB_G0277089 R-DDI-8956099 https://reactome.org/PathwayBrowser/#/R-DDI-8956099 VHL:EloB,C:NEDD8-CUL2:RBX1 complex binds UBXN7 IEA Dictyostelium discoideum DDB_G0277089 R-DDI-8956200 https://reactome.org/PathwayBrowser/#/R-DDI-8956200 MyrG-DCUN1D3 binds CRL1 E3 ubiquitin ligase complex IEA Dictyostelium discoideum DDB_G0277093 R-DDI-6798745 https://reactome.org/PathwayBrowser/#/R-DDI-6798745 Exocytosis of tertiary granule lumen proteins IEA Dictyostelium discoideum DDB_G0277107 R-DDI-429860 https://reactome.org/PathwayBrowser/#/R-DDI-429860 DCP1-DCP2 complex decaps mRNA IEA Dictyostelium discoideum DDB_G0277107 R-DDI-429978 https://reactome.org/PathwayBrowser/#/R-DDI-429978 Lsm1-7 Complex binds deadenylated mRNA IEA Dictyostelium discoideum DDB_G0277113 R-DDI-9603775 https://reactome.org/PathwayBrowser/#/R-DDI-9603775 PEX3:PEX19:class I PMP dissociates IEA Dictyostelium discoideum DDB_G0277113 R-DDI-9603784 https://reactome.org/PathwayBrowser/#/R-DDI-9603784 PEX19:class I PMP binds PEX3 IEA Dictyostelium discoideum DDB_G0277113 R-DDI-9603804 https://reactome.org/PathwayBrowser/#/R-DDI-9603804 PEX19 binds class I peroxisomal membrane proteins IEA Dictyostelium discoideum DDB_G0277133 R-DDI-5682388 https://reactome.org/PathwayBrowser/#/R-DDI-5682388 Autophagosome maturation IEA Dictyostelium discoideum DDB_G0277133 R-DDI-917693 https://reactome.org/PathwayBrowser/#/R-DDI-917693 ESCRT Disassembly IEA Dictyostelium discoideum DDB_G0277133 R-DDI-917700 https://reactome.org/PathwayBrowser/#/R-DDI-917700 MVB Vesicle Formation IEA Dictyostelium discoideum DDB_G0277133 R-DDI-9668335 https://reactome.org/PathwayBrowser/#/R-DDI-9668335 CHMP7 binds LEMD2 IEA Dictyostelium discoideum DDB_G0277133 R-DDI-9668389 https://reactome.org/PathwayBrowser/#/R-DDI-9668389 VPS4 binds ESCRT-III assemblies at nuclear envelope (NE) fenestrations IEA Dictyostelium discoideum DDB_G0277133 R-DDI-9668395 https://reactome.org/PathwayBrowser/#/R-DDI-9668395 CHMP7 binds CC2D1B IEA Dictyostelium discoideum DDB_G0277133 R-DDI-9668405 https://reactome.org/PathwayBrowser/#/R-DDI-9668405 SPAST (spastin) binds the IST1 subunit of ESCRT-III at the sites of microtubule attachment to chromatin IEA Dictyostelium discoideum DDB_G0277133 R-DDI-9668419 https://reactome.org/PathwayBrowser/#/R-DDI-9668419 SPAST (spastin) mediates the severing of microtubules at chromosome attachment sites IEA Dictyostelium discoideum DDB_G0277135 R-DDI-5694409 https://reactome.org/PathwayBrowser/#/R-DDI-5694409 Nucleotide exchange on RAB1 IEA Dictyostelium discoideum DDB_G0277135 R-DDI-5694439 https://reactome.org/PathwayBrowser/#/R-DDI-5694439 COPII coat binds TRAPPCII and RAB1:GDP IEA Dictyostelium discoideum DDB_G0277135 R-DDI-5694441 https://reactome.org/PathwayBrowser/#/R-DDI-5694441 CSNK1D phosphorylates SEC23 IEA Dictyostelium discoideum DDB_G0277135 R-DDI-8877475 https://reactome.org/PathwayBrowser/#/R-DDI-8877475 TRAPPC complexes exchange GTP for GDP on RAB1 IEA Dictyostelium discoideum DDB_G0277137 R-DDI-5696119 https://reactome.org/PathwayBrowser/#/R-DDI-5696119 AGMO cleaves alkylglycerol into fatty aldehyde and glycerol IEA Dictyostelium discoideum DDB_G0277139 R-DDI-392749 https://reactome.org/PathwayBrowser/#/R-DDI-392749 Transport of L1 into endosomes IEA Dictyostelium discoideum DDB_G0277139 R-DDI-445079 https://reactome.org/PathwayBrowser/#/R-DDI-445079 Phosphorylation of L1 by ERK IEA Dictyostelium discoideum DDB_G0277139 R-DDI-6784729 https://reactome.org/PathwayBrowser/#/R-DDI-6784729 PCSK9:LDLR:Clathrin-coated vesicle transport from plasma membrane to endolysosome IEA Dictyostelium discoideum DDB_G0277139 R-DDI-6784738 https://reactome.org/PathwayBrowser/#/R-DDI-6784738 Degradation of PCSK9:LDLR:Clathrin-coated vesicle IEA Dictyostelium discoideum DDB_G0277139 R-DDI-8855130 https://reactome.org/PathwayBrowser/#/R-DDI-8855130 VLDLR:PCSK9:Clathrin-coated vesicle translocates from the plasma membrane to lysosomal membrane IEA Dictyostelium discoideum DDB_G0277139 R-DDI-8856813 https://reactome.org/PathwayBrowser/#/R-DDI-8856813 AAK1 phosphorylates AP-2 mu subunit at T156 IEA Dictyostelium discoideum DDB_G0277139 R-DDI-8866277 https://reactome.org/PathwayBrowser/#/R-DDI-8866277 AP-2 directly binds some endocytic cargo IEA Dictyostelium discoideum DDB_G0277139 R-DDI-8868072 https://reactome.org/PathwayBrowser/#/R-DDI-8868072 Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2 IEA Dictyostelium discoideum DDB_G0277139 R-DDI-8871196 https://reactome.org/PathwayBrowser/#/R-DDI-8871196 Initial binding of AP-2 and clathrin to PI(4,5)P2 IEA Dictyostelium discoideum DDB_G0277139 R-DDI-9681616 https://reactome.org/PathwayBrowser/#/R-DDI-9681616 AP2 binds chlorpromazine IEA Dictyostelium discoideum DDB_G0277143 R-DDI-380073 https://reactome.org/PathwayBrowser/#/R-DDI-380073 Liganded Gi-activating GPCR acts as a GEF for Gi IEA Dictyostelium discoideum DDB_G0277143 R-DDI-392300 https://reactome.org/PathwayBrowser/#/R-DDI-392300 G beta:gamma activated PI3Kgamma converts PIP2 to PIP3 IEA Dictyostelium discoideum DDB_G0277143 R-DDI-6814119 https://reactome.org/PathwayBrowser/#/R-DDI-6814119 TRiC/CCT binds unfolded G-protein beta subunit IEA Dictyostelium discoideum DDB_G0277143 R-DDI-6814120 https://reactome.org/PathwayBrowser/#/R-DDI-6814120 ATP hydrolysis promotes folding of G-protein beta by TRiC/CCT IEA Dictyostelium discoideum DDB_G0277143 R-DDI-6814124 https://reactome.org/PathwayBrowser/#/R-DDI-6814124 ATP binds G-protein beta associated TRiC/CCT IEA Dictyostelium discoideum DDB_G0277173 R-DDI-376357 https://reactome.org/PathwayBrowser/#/R-DDI-376357 Vamp7 associated Lysosome to Plasma membrane transport IEA Dictyostelium discoideum DDB_G0277199 R-DDI-76056 https://reactome.org/PathwayBrowser/#/R-DDI-76056 Recruitment of RNA polymerase III to TFIIIB:TFIIIC:TFIIIA:Type 1 Promoter Complex IEA Dictyostelium discoideum DDB_G0277199 R-DDI-83805 https://reactome.org/PathwayBrowser/#/R-DDI-83805 Recruitment of RNA Polymerase III to the TFIIIB:TFIIIC: Type 2 Promoter Complex IEA Dictyostelium discoideum DDB_G0277211 R-DDI-430028 https://reactome.org/PathwayBrowser/#/R-DDI-430028 Exosome Complex hydrolyzes mRNA by 3' to 5' exoribonuclease digestion IEA Dictyostelium discoideum DDB_G0277221 R-DDI-392749 https://reactome.org/PathwayBrowser/#/R-DDI-392749 Transport of L1 into endosomes IEA Dictyostelium discoideum DDB_G0277221 R-DDI-445079 https://reactome.org/PathwayBrowser/#/R-DDI-445079 Phosphorylation of L1 by ERK IEA Dictyostelium discoideum DDB_G0277221 R-DDI-5333658 https://reactome.org/PathwayBrowser/#/R-DDI-5333658 CLAT:AP1:CLVS bind PI(3,5)P2 IEA Dictyostelium discoideum DDB_G0277221 R-DDI-6784729 https://reactome.org/PathwayBrowser/#/R-DDI-6784729 PCSK9:LDLR:Clathrin-coated vesicle transport from plasma membrane to endolysosome IEA Dictyostelium discoideum DDB_G0277221 R-DDI-6784738 https://reactome.org/PathwayBrowser/#/R-DDI-6784738 Degradation of PCSK9:LDLR:Clathrin-coated vesicle IEA Dictyostelium discoideum DDB_G0277221 R-DDI-8855130 https://reactome.org/PathwayBrowser/#/R-DDI-8855130 VLDLR:PCSK9:Clathrin-coated vesicle translocates from the plasma membrane to lysosomal membrane IEA Dictyostelium discoideum DDB_G0277221 R-DDI-8856813 https://reactome.org/PathwayBrowser/#/R-DDI-8856813 AAK1 phosphorylates AP-2 mu subunit at T156 IEA Dictyostelium discoideum DDB_G0277221 R-DDI-8868072 https://reactome.org/PathwayBrowser/#/R-DDI-8868072 Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2 IEA Dictyostelium discoideum DDB_G0277221 R-DDI-8871196 https://reactome.org/PathwayBrowser/#/R-DDI-8871196 Initial binding of AP-2 and clathrin to PI(4,5)P2 IEA Dictyostelium discoideum DDB_G0277221 R-DDI-9018766 https://reactome.org/PathwayBrowser/#/R-DDI-9018766 RHOU binds effectors at the plasma membrane IEA Dictyostelium discoideum DDB_G0277221 R-DDI-9018794 https://reactome.org/PathwayBrowser/#/R-DDI-9018794 RHOV binds effectors at the plasma membrane IEA Dictyostelium discoideum DDB_G0277223 R-DDI-426240 https://reactome.org/PathwayBrowser/#/R-DDI-426240 DAG kinase produces phosphatidic acid from DAG IEA Dictyostelium discoideum DDB_G0277231 R-DDI-6788523 https://reactome.org/PathwayBrowser/#/R-DDI-6788523 NUBPL transfers 4Fe-4S to Complex I subunits IEA Dictyostelium discoideum DDB_G0277231 R-DDI-6800868 https://reactome.org/PathwayBrowser/#/R-DDI-6800868 NDUF subunits bind to form the IP subcomplex IEA Dictyostelium discoideum DDB_G0277247 R-DDI-110224 https://reactome.org/PathwayBrowser/#/R-DDI-110224 Cleavage of thymine glycol by NTHL1 glycosylase IEA Dictyostelium discoideum DDB_G0277247 R-DDI-110226 https://reactome.org/PathwayBrowser/#/R-DDI-110226 Cleavage of cytosine glycol by NTHL1 glycosylase IEA Dictyostelium discoideum DDB_G0277247 R-DDI-110227 https://reactome.org/PathwayBrowser/#/R-DDI-110227 Cleavage of dihydrouracil by NTHL1 glycosylase IEA Dictyostelium discoideum DDB_G0277247 R-DDI-110229 https://reactome.org/PathwayBrowser/#/R-DDI-110229 Cleavage of formamidopyrimidine (FapyA) by NTHL1 glycosylase IEA Dictyostelium discoideum DDB_G0277247 R-DDI-110352 https://reactome.org/PathwayBrowser/#/R-DDI-110352 Displacement of NTHL1 glycosylase by APEX1 at the AP site IEA Dictyostelium discoideum DDB_G0277249 R-DDI-8952039 https://reactome.org/PathwayBrowser/#/R-DDI-8952039 NEDD8:AcM-UBE2F binds CRL5 E3 ubiquitin ligase complex IEA Dictyostelium discoideum DDB_G0277249 R-DDI-8952044 https://reactome.org/PathwayBrowser/#/R-DDI-8952044 AcM-UBE2F transfers NEDD8 to CRL5 E3 ubiquitin ligase complex IEA Dictyostelium discoideum DDB_G0277249 R-DDI-8955241 https://reactome.org/PathwayBrowser/#/R-DDI-8955241 CAND1 binds cytosolic CRL E3 ubiquitin ligases IEA Dictyostelium discoideum DDB_G0277249 R-DDI-8955289 https://reactome.org/PathwayBrowser/#/R-DDI-8955289 COMMDs displace CAND1 from cytosolic CRL E3 ubiquitin ligase complexes IEA Dictyostelium discoideum DDB_G0277249 R-DDI-8956040 https://reactome.org/PathwayBrowser/#/R-DDI-8956040 COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes IEA Dictyostelium discoideum DDB_G0277249 R-DDI-983140 https://reactome.org/PathwayBrowser/#/R-DDI-983140 Transfer of Ub from E2 to substrate and release of E2 IEA Dictyostelium discoideum DDB_G0277249 R-DDI-983147 https://reactome.org/PathwayBrowser/#/R-DDI-983147 Release of E3 from polyubiquitinated substrate IEA Dictyostelium discoideum DDB_G0277249 R-DDI-983156 https://reactome.org/PathwayBrowser/#/R-DDI-983156 Polyubiquitination of substrate IEA Dictyostelium discoideum DDB_G0277249 R-DDI-983157 https://reactome.org/PathwayBrowser/#/R-DDI-983157 Interaction of E3 with substrate and E2-Ub complex IEA Dictyostelium discoideum DDB_G0277257 R-DDI-9639287 https://reactome.org/PathwayBrowser/#/R-DDI-9639287 SESN1,2 binds L-leucine and dissociates from GATOR2 IEA Dictyostelium discoideum DDB_G0277257 R-DDI-9640195 https://reactome.org/PathwayBrowser/#/R-DDI-9640195 RRAGA,B hydrolyzes GTP IEA Dictyostelium discoideum DDB_G0277263 R-DDI-444126 https://reactome.org/PathwayBrowser/#/R-DDI-444126 HUT2 and HUT11 mediate urea transport in kidney and erythrocytes respectively IEA Dictyostelium discoideum DDB_G0277267 R-DDI-1169402 https://reactome.org/PathwayBrowser/#/R-DDI-1169402 ISGylation of E2 conjugating enzymes IEA Dictyostelium discoideum DDB_G0277267 R-DDI-446877 https://reactome.org/PathwayBrowser/#/R-DDI-446877 TRAF6 is K63 poly-ubiquitinated IEA Dictyostelium discoideum DDB_G0277267 R-DDI-451418 https://reactome.org/PathwayBrowser/#/R-DDI-451418 Pellino ubiquitinates IRAK1 IEA Dictyostelium discoideum DDB_G0277267 R-DDI-5683405 https://reactome.org/PathwayBrowser/#/R-DDI-5683405 PPP5C dephosphorylates TP53BP1 IEA Dictyostelium discoideum DDB_G0277267 R-DDI-5683425 https://reactome.org/PathwayBrowser/#/R-DDI-5683425 ATM phosphorylates TP53BP1 at DNA DSBs IEA Dictyostelium discoideum DDB_G0277267 R-DDI-5693566 https://reactome.org/PathwayBrowser/#/R-DDI-5693566 TP53BP1 associates with H4K20Me2 at DNA DSBs IEA Dictyostelium discoideum DDB_G0277267 R-DDI-8938815 https://reactome.org/PathwayBrowser/#/R-DDI-8938815 RNF152 polyubiquitinates RRAGA IEA Dictyostelium discoideum DDB_G0277267 R-DDI-8938829 https://reactome.org/PathwayBrowser/#/R-DDI-8938829 RNF152 binds RRAGA:GDP and Ubiquitin:UBE2D3 IEA Dictyostelium discoideum DDB_G0277267 R-DDI-8943003 https://reactome.org/PathwayBrowser/#/R-DDI-8943003 SHPRH polyubiquitinates monoubiquitinated PCNA IEA Dictyostelium discoideum DDB_G0277267 R-DDI-8943007 https://reactome.org/PathwayBrowser/#/R-DDI-8943007 SHPRH binds monoUb-K164-PCNA, RAD6:RAD18, UBE2V2:Ub:UBE2N IEA Dictyostelium discoideum DDB_G0277267 R-DDI-9641089 https://reactome.org/PathwayBrowser/#/R-DDI-9641089 Parkin binds Ub:UBE2N:UBE2V1 IEA Dictyostelium discoideum DDB_G0277267 R-DDI-9641096 https://reactome.org/PathwayBrowser/#/R-DDI-9641096 Misfolded proteins bind PRKN:UBE2N:UBE2V1:Ub IEA Dictyostelium discoideum DDB_G0277267 R-DDI-9641109 https://reactome.org/PathwayBrowser/#/R-DDI-9641109 PolyUb:misfolded proteins dissociate from PRKN:UBE2N:UBE2V1 IEA Dictyostelium discoideum DDB_G0277267 R-DDI-9641111 https://reactome.org/PathwayBrowser/#/R-DDI-9641111 Parkin transfers Ub to misfolded proteins IEA Dictyostelium discoideum DDB_G0277267 R-DDI-9641127 https://reactome.org/PathwayBrowser/#/R-DDI-9641127 Ub:misfolded proteins polymerize to PolyUb:misfolded proteins IEA Dictyostelium discoideum DDB_G0277267 R-DDI-983140 https://reactome.org/PathwayBrowser/#/R-DDI-983140 Transfer of Ub from E2 to substrate and release of E2 IEA Dictyostelium discoideum DDB_G0277267 R-DDI-983152 https://reactome.org/PathwayBrowser/#/R-DDI-983152 Transfer of ubiquitin from E1 to E2 IEA Dictyostelium discoideum DDB_G0277267 R-DDI-983156 https://reactome.org/PathwayBrowser/#/R-DDI-983156 Polyubiquitination of substrate IEA Dictyostelium discoideum DDB_G0277267 R-DDI-983157 https://reactome.org/PathwayBrowser/#/R-DDI-983157 Interaction of E3 with substrate and E2-Ub complex IEA Dictyostelium discoideum DDB_G0277275 R-DDI-209815 https://reactome.org/PathwayBrowser/#/R-DDI-209815 Tyrosine is monoiodinated IEA Dictyostelium discoideum DDB_G0277275 R-DDI-209840 https://reactome.org/PathwayBrowser/#/R-DDI-209840 Two DITs combine to form thyroxine IEA Dictyostelium discoideum DDB_G0277275 R-DDI-209925 https://reactome.org/PathwayBrowser/#/R-DDI-209925 DIT and MIT combine to form triiodothyronine IEA Dictyostelium discoideum DDB_G0277275 R-DDI-209973 https://reactome.org/PathwayBrowser/#/R-DDI-209973 Tyrosine is diiodinated IEA Dictyostelium discoideum DDB_G0277275 R-DDI-350901 https://reactome.org/PathwayBrowser/#/R-DDI-350901 Iodide is organified IEA Dictyostelium discoideum DDB_G0277275 R-DDI-6789031 https://reactome.org/PathwayBrowser/#/R-DDI-6789031 Membrane-bound myeloperoxidase (MPO) produces hypochlorous acid (HOCl) IEA Dictyostelium discoideum DDB_G0277275 R-DDI-6789126 https://reactome.org/PathwayBrowser/#/R-DDI-6789126 Myeloperoxidase (MPO) produces hypochlorous acid (HOCl) IEA Dictyostelium discoideum DDB_G0277275 R-DDI-6789136 https://reactome.org/PathwayBrowser/#/R-DDI-6789136 Myeloperoxidase (MPO) binds to the bacterial cell surface IEA Dictyostelium discoideum DDB_G0277275 R-DDI-6798748 https://reactome.org/PathwayBrowser/#/R-DDI-6798748 Exocytosis of secretory granule lumen proteins IEA Dictyostelium discoideum DDB_G0277275 R-DDI-6798751 https://reactome.org/PathwayBrowser/#/R-DDI-6798751 Exocytosis of azurophil granule lumen proteins IEA Dictyostelium discoideum DDB_G0277275 R-DDI-8855490 https://reactome.org/PathwayBrowser/#/R-DDI-8855490 Lactoperoxidase (LPO) produces OSCN- IEA Dictyostelium discoideum DDB_G0277275 R-DDI-8933635 https://reactome.org/PathwayBrowser/#/R-DDI-8933635 Myeloperoxidase (MPO) catalyzes oxidation of nitrite to nitrogen dioxide IEA Dictyostelium discoideum DDB_G0277279 R-DDI-6791222 https://reactome.org/PathwayBrowser/#/R-DDI-6791222 21S pre-rRNA is nucleolytically processed at site E (site2a) to yield 18SE pre-rRNA IEA Dictyostelium discoideum DDB_G0277319 R-DDI-5678490 https://reactome.org/PathwayBrowser/#/R-DDI-5678490 ATG16L1 complex transfers LC3 from ATG3 to PE IEA Dictyostelium discoideum DDB_G0277319 R-DDI-5681981 https://reactome.org/PathwayBrowser/#/R-DDI-5681981 ATG3 transfers LC3 from ATG7 to ATG3 IEA Dictyostelium discoideum DDB_G0277319 R-DDI-5682896 https://reactome.org/PathwayBrowser/#/R-DDI-5682896 LC3:ATG7 dimer binds ATG3 IEA Dictyostelium discoideum DDB_G0277319 R-DDI-5683593 https://reactome.org/PathwayBrowser/#/R-DDI-5683593 ATG7:ATG3:LC3 dissociates IEA Dictyostelium discoideum DDB_G0277331 R-DDI-4827383 https://reactome.org/PathwayBrowser/#/R-DDI-4827383 WHSC1 (KMT3G), NSD1 (KMT3B), SMYD2 (KMT3C) methylate lysine-37 of histone H3 (H3K36) IEA Dictyostelium discoideum DDB_G0277331 R-DDI-5638157 https://reactome.org/PathwayBrowser/#/R-DDI-5638157 WHSC1 (KMT3G), NSD1 (KMT3B), SMYD2 (KMT3C), ASH1L methylate methyl-lysine-37 of histone H3 (H3K36) IEA Dictyostelium discoideum DDB_G0277335 R-DDI-9033235 https://reactome.org/PathwayBrowser/#/R-DDI-9033235 Cargo of PEX5S,L translocates from the cytosol to the peroxisomal matrix IEA Dictyostelium discoideum DDB_G0277335 R-DDI-9033236 https://reactome.org/PathwayBrowser/#/R-DDI-9033236 PEX5S,L:Cargo binds PEX13:PEX14:PEX2:PEX10:PEX12 (Docking and Translocation Module) IEA Dictyostelium discoideum DDB_G0277343 R-DDI-114683 https://reactome.org/PathwayBrowser/#/R-DDI-114683 Phosphorylation of Platelet Sec-1 IEA Dictyostelium discoideum DDB_G0277343 R-DDI-449117 https://reactome.org/PathwayBrowser/#/R-DDI-449117 TXLNA (IL14) binds syntaxin1A IEA Dictyostelium discoideum DDB_G0277343 R-DDI-482772 https://reactome.org/PathwayBrowser/#/R-DDI-482772 Release of platelet cytosolic components IEA Dictyostelium discoideum DDB_G0277345 R-DDI-156823 https://reactome.org/PathwayBrowser/#/R-DDI-156823 Association of phospho-L13a with GAIT element of Ceruloplasmin mRNA IEA Dictyostelium discoideum DDB_G0277345 R-DDI-1799332 https://reactome.org/PathwayBrowser/#/R-DDI-1799332 Nascent polypeptide:mRNA:ribosome complex binds signal recognition particle (SRP) IEA Dictyostelium discoideum DDB_G0277345 R-DDI-72621 https://reactome.org/PathwayBrowser/#/R-DDI-72621 Ribosomal scanning IEA Dictyostelium discoideum DDB_G0277345 R-DDI-72671 https://reactome.org/PathwayBrowser/#/R-DDI-72671 eIF5B:GTP is hydrolyzed and released IEA Dictyostelium discoideum DDB_G0277345 R-DDI-72672 https://reactome.org/PathwayBrowser/#/R-DDI-72672 The 60S subunit joins the translation initiation complex IEA Dictyostelium discoideum DDB_G0277345 R-DDI-72673 https://reactome.org/PathwayBrowser/#/R-DDI-72673 Release of 40S and 60S subunits from the 80S ribosome IEA Dictyostelium discoideum DDB_G0277345 R-DDI-72676 https://reactome.org/PathwayBrowser/#/R-DDI-72676 eIF3 and eIF1A bind to the 40S subunit IEA Dictyostelium discoideum DDB_G0277345 R-DDI-72691 https://reactome.org/PathwayBrowser/#/R-DDI-72691 Formation of the 43S pre-initiation complex IEA Dictyostelium discoideum DDB_G0277345 R-DDI-72697 https://reactome.org/PathwayBrowser/#/R-DDI-72697 Start codon recognition IEA Dictyostelium discoideum DDB_G0277345 R-DDI-927789 https://reactome.org/PathwayBrowser/#/R-DDI-927789 Formation of UPF1:eRF3 complex on mRNA with a premature termination codon and no Exon Junction Complex IEA Dictyostelium discoideum DDB_G0277345 R-DDI-927832 https://reactome.org/PathwayBrowser/#/R-DDI-927832 UPF1 binds an mRNP with a termination codon preceding an Exon Junction Complex IEA Dictyostelium discoideum DDB_G0277345 R-DDI-927889 https://reactome.org/PathwayBrowser/#/R-DDI-927889 SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex) IEA Dictyostelium discoideum DDB_G0277345 R-DDI-936390 https://reactome.org/PathwayBrowser/#/R-DDI-936390 CYLD mediated deubiquitination of DDX58 (RIG-I) IEA Dictyostelium discoideum DDB_G0277357 R-DDI-914005 https://reactome.org/PathwayBrowser/#/R-DDI-914005 Addition of GlcNAc to the Tn antigen via an alpha-1,3 linkage forms a Core 5 glycoprotein IEA Dictyostelium discoideum DDB_G0277357 R-DDI-914006 https://reactome.org/PathwayBrowser/#/R-DDI-914006 Addition of galactose to the Tn antigen via an alpha-1,3 linkage forms a Core 8 glycoprotein IEA Dictyostelium discoideum DDB_G0277357 R-DDI-914008 https://reactome.org/PathwayBrowser/#/R-DDI-914008 Addition of GlcNAc to the Tn antigen via a beta-1,6 linkage forms a Core 6 glycoprotein IEA Dictyostelium discoideum DDB_G0277357 R-DDI-914017 https://reactome.org/PathwayBrowser/#/R-DDI-914017 Addition of GalNAc to the Tn antigen via an alpha-1,6 linkage forms a Core 7 glycoprotein IEA Dictyostelium discoideum DDB_G0277375 R-DDI-6814555 https://reactome.org/PathwayBrowser/#/R-DDI-6814555 Integrator complex processes the 3' end of snRNA IEA Dictyostelium discoideum DDB_G0277375 R-DDI-9770236 https://reactome.org/PathwayBrowser/#/R-DDI-9770236 Formation of the Spliceosomal P complex and exon ligation IEA Dictyostelium discoideum DDB_G0277383 R-DDI-77584 https://reactome.org/PathwayBrowser/#/R-DDI-77584 Binding of SLBP to Replication-Dependent Histone Pre-mRNA IEA Dictyostelium discoideum DDB_G0277383 R-DDI-77585 https://reactome.org/PathwayBrowser/#/R-DDI-77585 Recruitment of U7 snRNP:ZFP100 complex to the SLBP Bound Pre-mRNA IEA Dictyostelium discoideum DDB_G0277383 R-DDI-77586 https://reactome.org/PathwayBrowser/#/R-DDI-77586 Cleavage of the 3'-end of Replication Dependent Histone Pre-mRNA IEA Dictyostelium discoideum DDB_G0277397 R-DDI-6811428 https://reactome.org/PathwayBrowser/#/R-DDI-6811428 RIC1:RGP1 recruits RAB6:GDP to the TGN IEA Dictyostelium discoideum DDB_G0277397 R-DDI-6811429 https://reactome.org/PathwayBrowser/#/R-DDI-6811429 RIC1:RGP1 stimulates nucleotide RAB6 nucleotide exchange IEA Dictyostelium discoideum DDB_G0277397 R-DDI-8847887 https://reactome.org/PathwayBrowser/#/R-DDI-8847887 RAB33B:GTP binds RIC1:RGP1 IEA Dictyostelium discoideum DDB_G0277397 R-DDI-8876193 https://reactome.org/PathwayBrowser/#/R-DDI-8876193 RIC1-RGP1 exchanges GTP for GDP on RAB6 IEA Dictyostelium discoideum DDB_G0277399 R-DDI-198640 https://reactome.org/PathwayBrowser/#/R-DDI-198640 TORC2 (mTOR) phosphorylates AKT at S473 IEA Dictyostelium discoideum DDB_G0277399 R-DDI-6795290 https://reactome.org/PathwayBrowser/#/R-DDI-6795290 TORC2 complex phosphorylates SGK1 IEA Dictyostelium discoideum DDB_G0277399 R-DDI-9860800 https://reactome.org/PathwayBrowser/#/R-DDI-9860800 mTORC2 phosphorylates AKT1 on serine-473 IEA Dictyostelium discoideum DDB_G0277401 R-DDI-1222516 https://reactome.org/PathwayBrowser/#/R-DDI-1222516 Intraphagosomal pH is lowered to 5 by V-ATPase IEA Dictyostelium discoideum DDB_G0277401 R-DDI-74723 https://reactome.org/PathwayBrowser/#/R-DDI-74723 Endosome acidification IEA Dictyostelium discoideum DDB_G0277401 R-DDI-917841 https://reactome.org/PathwayBrowser/#/R-DDI-917841 Acidification of Tf:TfR1 containing endosome IEA Dictyostelium discoideum DDB_G0277401 R-DDI-9639286 https://reactome.org/PathwayBrowser/#/R-DDI-9639286 RRAGC,D exchanges GTP for GDP IEA Dictyostelium discoideum DDB_G0277401 R-DDI-9640167 https://reactome.org/PathwayBrowser/#/R-DDI-9640167 RRAGA,B exchanges GDP for GTP IEA Dictyostelium discoideum DDB_G0277401 R-DDI-9640195 https://reactome.org/PathwayBrowser/#/R-DDI-9640195 RRAGA,B hydrolyzes GTP IEA Dictyostelium discoideum DDB_G0277401 R-DDI-9645598 https://reactome.org/PathwayBrowser/#/R-DDI-9645598 RRAGC,D hydrolyzes GTP IEA Dictyostelium discoideum DDB_G0277401 R-DDI-9645608 https://reactome.org/PathwayBrowser/#/R-DDI-9645608 v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP binds mTORC1 IEA Dictyostelium discoideum DDB_G0277401 R-DDI-9646468 https://reactome.org/PathwayBrowser/#/R-DDI-9646468 mTORC1 binds RHEB:GTP IEA Dictyostelium discoideum DDB_G0277403 R-DDI-392749 https://reactome.org/PathwayBrowser/#/R-DDI-392749 Transport of L1 into endosomes IEA Dictyostelium discoideum DDB_G0277403 R-DDI-445079 https://reactome.org/PathwayBrowser/#/R-DDI-445079 Phosphorylation of L1 by ERK IEA Dictyostelium discoideum DDB_G0277403 R-DDI-5333658 https://reactome.org/PathwayBrowser/#/R-DDI-5333658 CLAT:AP1:CLVS bind PI(3,5)P2 IEA Dictyostelium discoideum DDB_G0277403 R-DDI-6784729 https://reactome.org/PathwayBrowser/#/R-DDI-6784729 PCSK9:LDLR:Clathrin-coated vesicle transport from plasma membrane to endolysosome IEA Dictyostelium discoideum DDB_G0277403 R-DDI-6784738 https://reactome.org/PathwayBrowser/#/R-DDI-6784738 Degradation of PCSK9:LDLR:Clathrin-coated vesicle IEA Dictyostelium discoideum DDB_G0277403 R-DDI-8855130 https://reactome.org/PathwayBrowser/#/R-DDI-8855130 VLDLR:PCSK9:Clathrin-coated vesicle translocates from the plasma membrane to lysosomal membrane IEA Dictyostelium discoideum DDB_G0277403 R-DDI-8856813 https://reactome.org/PathwayBrowser/#/R-DDI-8856813 AAK1 phosphorylates AP-2 mu subunit at T156 IEA Dictyostelium discoideum DDB_G0277403 R-DDI-8868072 https://reactome.org/PathwayBrowser/#/R-DDI-8868072 Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2 IEA Dictyostelium discoideum DDB_G0277403 R-DDI-8871196 https://reactome.org/PathwayBrowser/#/R-DDI-8871196 Initial binding of AP-2 and clathrin to PI(4,5)P2 IEA Dictyostelium discoideum DDB_G0277413 R-DDI-376419 https://reactome.org/PathwayBrowser/#/R-DDI-376419 Formation of NR-MED1 Coactivator Complex IEA Dictyostelium discoideum DDB_G0277429 R-DDI-5683405 https://reactome.org/PathwayBrowser/#/R-DDI-5683405 PPP5C dephosphorylates TP53BP1 IEA Dictyostelium discoideum DDB_G0277429 R-DDI-5683425 https://reactome.org/PathwayBrowser/#/R-DDI-5683425 ATM phosphorylates TP53BP1 at DNA DSBs IEA Dictyostelium discoideum DDB_G0277429 R-DDI-5693566 https://reactome.org/PathwayBrowser/#/R-DDI-5693566 TP53BP1 associates with H4K20Me2 at DNA DSBs IEA Dictyostelium discoideum DDB_G0277429 R-DDI-983140 https://reactome.org/PathwayBrowser/#/R-DDI-983140 Transfer of Ub from E2 to substrate and release of E2 IEA Dictyostelium discoideum DDB_G0277429 R-DDI-983147 https://reactome.org/PathwayBrowser/#/R-DDI-983147 Release of E3 from polyubiquitinated substrate IEA Dictyostelium discoideum DDB_G0277429 R-DDI-983156 https://reactome.org/PathwayBrowser/#/R-DDI-983156 Polyubiquitination of substrate IEA Dictyostelium discoideum DDB_G0277429 R-DDI-983157 https://reactome.org/PathwayBrowser/#/R-DDI-983157 Interaction of E3 with substrate and E2-Ub complex IEA Dictyostelium discoideum DDB_G0277439 R-DDI-174227 https://reactome.org/PathwayBrowser/#/R-DDI-174227 Ubiquitination of Cyclin B by phospho-APC/C:Cdc20 complex IEA Dictyostelium discoideum DDB_G0277449 R-DDI-165718 https://reactome.org/PathwayBrowser/#/R-DDI-165718 mTORC1 phosphorylation of RPS6KB1 (S6K) IEA Dictyostelium discoideum DDB_G0277449 R-DDI-165726 https://reactome.org/PathwayBrowser/#/R-DDI-165726 Phosphorylation of Ribosomal protein S6 by activated S6K1 IEA Dictyostelium discoideum DDB_G0277449 R-DDI-165758 https://reactome.org/PathwayBrowser/#/R-DDI-165758 Phosphorylation and inactivation of eEF2K by activated S6K1 IEA Dictyostelium discoideum DDB_G0277449 R-DDI-165766 https://reactome.org/PathwayBrowser/#/R-DDI-165766 Phosphorylation and activation of eIF4G by activated S6K1 IEA Dictyostelium discoideum DDB_G0277449 R-DDI-198669 https://reactome.org/PathwayBrowser/#/R-DDI-198669 p38MAPK phosphorylates MSK1 IEA Dictyostelium discoideum DDB_G0277449 R-DDI-198746 https://reactome.org/PathwayBrowser/#/R-DDI-198746 ERK1/2/5 activate RSK1/2/3 IEA Dictyostelium discoideum DDB_G0277449 R-DDI-198756 https://reactome.org/PathwayBrowser/#/R-DDI-198756 ERK1/2 phosphorylates MSK1 IEA Dictyostelium discoideum DDB_G0277449 R-DDI-199839 https://reactome.org/PathwayBrowser/#/R-DDI-199839 AKT can phosphorylate RSK IEA Dictyostelium discoideum DDB_G0277449 R-DDI-9029434 https://reactome.org/PathwayBrowser/#/R-DDI-9029434 p-S363,S380,T573 RS6K translocates to the nucleus IEA Dictyostelium discoideum DDB_G0277477 R-DDI-389891 https://reactome.org/PathwayBrowser/#/R-DDI-389891 (2S)-pristanoyl-CoA + O2 => trans-2,3-dehydropristanoyl-CoA + H2O2 (ACOX3) IEA Dictyostelium discoideum DDB_G0277477 R-DDI-9033235 https://reactome.org/PathwayBrowser/#/R-DDI-9033235 Cargo of PEX5S,L translocates from the cytosol to the peroxisomal matrix IEA Dictyostelium discoideum DDB_G0277477 R-DDI-9033236 https://reactome.org/PathwayBrowser/#/R-DDI-9033236 PEX5S,L:Cargo binds PEX13:PEX14:PEX2:PEX10:PEX12 (Docking and Translocation Module) IEA Dictyostelium discoideum DDB_G0277493 R-DDI-391266 https://reactome.org/PathwayBrowser/#/R-DDI-391266 Association of CCT/TriC with sphingosine kinase 1 IEA Dictyostelium discoideum DDB_G0277493 R-DDI-6814119 https://reactome.org/PathwayBrowser/#/R-DDI-6814119 TRiC/CCT binds unfolded G-protein beta subunit IEA Dictyostelium discoideum DDB_G0277493 R-DDI-6814120 https://reactome.org/PathwayBrowser/#/R-DDI-6814120 ATP hydrolysis promotes folding of G-protein beta by TRiC/CCT IEA Dictyostelium discoideum DDB_G0277493 R-DDI-6814124 https://reactome.org/PathwayBrowser/#/R-DDI-6814124 ATP binds G-protein beta associated TRiC/CCT IEA Dictyostelium discoideum DDB_G0277493 R-DDI-9018787 https://reactome.org/PathwayBrowser/#/R-DDI-9018787 RHOBTB2 binds interacting proteins at the endosome membrane IEA Dictyostelium discoideum DDB_G0277511 R-DDI-71163 https://reactome.org/PathwayBrowser/#/R-DDI-71163 HPD dioxygenates HPP IEA Dictyostelium discoideum DDB_G0277511 R-DDI-9856718 https://reactome.org/PathwayBrowser/#/R-DDI-9856718 HPDL dioxygenates HPPA IEA Dictyostelium discoideum DDB_G0277533 R-DDI-5696605 https://reactome.org/PathwayBrowser/#/R-DDI-5696605 USP12, USP26 deubiquitinate AR IEA Dictyostelium discoideum DDB_G0277537 R-DDI-1675813 https://reactome.org/PathwayBrowser/#/R-DDI-1675813 PI is phosphorylated to PI4P by PI4KA/2B at the ER membrane IEA Dictyostelium discoideum DDB_G0277537 R-DDI-1676185 https://reactome.org/PathwayBrowser/#/R-DDI-1676185 PI is phosphorylated to PI4P by PI4KA/2A/2B at the Golgi membrane IEA Dictyostelium discoideum DDB_G0277539 R-DDI-156699 https://reactome.org/PathwayBrowser/#/R-DDI-156699 Inactivation of Wee1 kinase IEA Dictyostelium discoideum DDB_G0277539 R-DDI-162657 https://reactome.org/PathwayBrowser/#/R-DDI-162657 Inactivation of Myt1 kinase IEA Dictyostelium discoideum DDB_G0277545 R-DDI-143468 https://reactome.org/PathwayBrowser/#/R-DDI-143468 MEOS oxidizes ethanol to acetaldehyde IEA Dictyostelium discoideum DDB_G0277545 R-DDI-156526 https://reactome.org/PathwayBrowser/#/R-DDI-156526 CYP1A2,3A4,3A5,2A13 oxidise AFB1 to AFXBO IEA Dictyostelium discoideum DDB_G0277545 R-DDI-211874 https://reactome.org/PathwayBrowser/#/R-DDI-211874 CYP2S1 4-hydroxylates atRA IEA Dictyostelium discoideum DDB_G0277545 R-DDI-211881 https://reactome.org/PathwayBrowser/#/R-DDI-211881 Coumarin is 7-hydroxylated by CYP2A13 IEA Dictyostelium discoideum DDB_G0277545 R-DDI-211910 https://reactome.org/PathwayBrowser/#/R-DDI-211910 CYP2C8 inactivates paclitaxel by 6alpha-hydroxylation IEA Dictyostelium discoideum DDB_G0277545 R-DDI-211929 https://reactome.org/PathwayBrowser/#/R-DDI-211929 CYP2C19 5-hydroxylates omeprazole IEA Dictyostelium discoideum DDB_G0277545 R-DDI-211960 https://reactome.org/PathwayBrowser/#/R-DDI-211960 CYP2U1 19-hydroxylates ARA IEA Dictyostelium discoideum DDB_G0277545 R-DDI-211966 https://reactome.org/PathwayBrowser/#/R-DDI-211966 CYP2D6 4-hydroxylates debrisoquine IEA Dictyostelium discoideum DDB_G0277545 R-DDI-211968 https://reactome.org/PathwayBrowser/#/R-DDI-211968 CYP2W1 oxidises INDOL IEA Dictyostelium discoideum DDB_G0277545 R-DDI-211983 https://reactome.org/PathwayBrowser/#/R-DDI-211983 CYP2J2 oxidises ARA IEA Dictyostelium discoideum DDB_G0277545 R-DDI-211988 https://reactome.org/PathwayBrowser/#/R-DDI-211988 CYP2C9 inactivates tolbutamide by 4methyl-hydroxylation IEA Dictyostelium discoideum DDB_G0277545 R-DDI-211991 https://reactome.org/PathwayBrowser/#/R-DDI-211991 Cyclophosphamide is 4-hydroxylated by CYP2B6 IEA Dictyostelium discoideum DDB_G0277545 R-DDI-212004 https://reactome.org/PathwayBrowser/#/R-DDI-212004 CYP2C18 initiates bioactivation of phenytoin by 4-hydroxylation IEA Dictyostelium discoideum DDB_G0277545 R-DDI-212005 https://reactome.org/PathwayBrowser/#/R-DDI-212005 CYP2F1 dehydrogenates 3-methylindole IEA Dictyostelium discoideum DDB_G0277545 R-DDI-2161814 https://reactome.org/PathwayBrowser/#/R-DDI-2161814 Arachidonate is hydroxylated to 19-HETE by CYP(2) IEA Dictyostelium discoideum DDB_G0277545 R-DDI-2161890 https://reactome.org/PathwayBrowser/#/R-DDI-2161890 Arachidonate is epoxidated to 5,6-EET by CYP(4) IEA Dictyostelium discoideum DDB_G0277545 R-DDI-2161899 https://reactome.org/PathwayBrowser/#/R-DDI-2161899 Arachidonate is epoxidated to 8,9-EET by CYP(5) IEA Dictyostelium discoideum DDB_G0277545 R-DDI-2161940 https://reactome.org/PathwayBrowser/#/R-DDI-2161940 Arachidonate is hydroxylated to 20-HETE by CYP(3) IEA Dictyostelium discoideum DDB_G0277545 R-DDI-5423647 https://reactome.org/PathwayBrowser/#/R-DDI-5423647 CYP2A13 oxidises AFM1 to AFM1E IEA Dictyostelium discoideum DDB_G0277545 R-DDI-76354 https://reactome.org/PathwayBrowser/#/R-DDI-76354 Vinyl chloride is oxidized to 2-Chloroethylene oxide IEA Dictyostelium discoideum DDB_G0277545 R-DDI-76397 https://reactome.org/PathwayBrowser/#/R-DDI-76397 Acetaminophen oxidised to N-acetylbenzoquinoneimine (NAPQI) IEA Dictyostelium discoideum DDB_G0277545 R-DDI-76416 https://reactome.org/PathwayBrowser/#/R-DDI-76416 Benzene is hydroxylated to phenol IEA Dictyostelium discoideum DDB_G0277545 R-DDI-76434 https://reactome.org/PathwayBrowser/#/R-DDI-76434 Dehalogenation of carbon tetrachloride to form a free radical IEA Dictyostelium discoideum DDB_G0277545 R-DDI-76453 https://reactome.org/PathwayBrowser/#/R-DDI-76453 Coumarin is 7-hydroxylated by CYP2A6 IEA Dictyostelium discoideum DDB_G0277545 R-DDI-76456 https://reactome.org/PathwayBrowser/#/R-DDI-76456 O-atom dealkylation of dextromethorphan IEA Dictyostelium discoideum DDB_G0277545 R-DDI-76475 https://reactome.org/PathwayBrowser/#/R-DDI-76475 Dehalogenation of the poly-halogenated hydrocarbon Halothane to form the acylhalide Trifluoroacetlychloride and hydrogen bromide IEA Dictyostelium discoideum DDB_G0277545 R-DDI-9027043 https://reactome.org/PathwayBrowser/#/R-DDI-9027043 CYPs hydroxylate DHA to 14(R)-HDHA IEA Dictyostelium discoideum DDB_G0277545 R-DDI-9027302 https://reactome.org/PathwayBrowser/#/R-DDI-9027302 CYP2E1 oxidises 14(S)-HDHA to 14(S),21(R)-diHDHA and 14(S),21(S)-diHDHA IEA Dictyostelium discoideum DDB_G0277545 R-DDI-9027321 https://reactome.org/PathwayBrowser/#/R-DDI-9027321 CYP2E1 oxidises 14(R)-HDHA to 14(R),21(R)-diHDHA and 14(R),21(S)-diHDHA IEA Dictyostelium discoideum DDB_G0277545 R-DDI-9680865 https://reactome.org/PathwayBrowser/#/R-DDI-9680865 CYP3A4, CYP2B6 bind ritonavir IEA Dictyostelium discoideum DDB_G0277545 R-DDI-9749986 https://reactome.org/PathwayBrowser/#/R-DDI-9749986 CYP2,3 cytochromes hydroxylate ST to 2,3-DHBA IEA Dictyostelium discoideum DDB_G0277545 R-DDI-9750016 https://reactome.org/PathwayBrowser/#/R-DDI-9750016 CYP2,3 cytochromes hydroxylate ST to 2,5-DHBA IEA Dictyostelium discoideum DDB_G0277545 R-DDI-9753285 https://reactome.org/PathwayBrowser/#/R-DDI-9753285 CYP2E1 monooxygenates APAP to NAPQI IEA Dictyostelium discoideum DDB_G0277545 R-DDI-9915971 https://reactome.org/PathwayBrowser/#/R-DDI-9915971 Arachidonate is epoxidated to 11,12-EET by CYP(5) IEA Dictyostelium discoideum DDB_G0277545 R-DDI-9915997 https://reactome.org/PathwayBrowser/#/R-DDI-9915997 Arachidonate is epoxidated to 14,15-EET by CYP(5) IEA Dictyostelium discoideum DDB_G0277561 R-DDI-6809003 https://reactome.org/PathwayBrowser/#/R-DDI-6809003 ERGIC-to-Golgi vesicles bind dynein:dynactin IEA Dictyostelium discoideum DDB_G0277565 R-DDI-204008 https://reactome.org/PathwayBrowser/#/R-DDI-204008 SEC31:SEC13 and v-SNARE recruitment IEA Dictyostelium discoideum DDB_G0277565 R-DDI-5694409 https://reactome.org/PathwayBrowser/#/R-DDI-5694409 Nucleotide exchange on RAB1 IEA Dictyostelium discoideum DDB_G0277565 R-DDI-5694413 https://reactome.org/PathwayBrowser/#/R-DDI-5694413 SEC4C,D bind GOSR2 and STX5 IEA Dictyostelium discoideum DDB_G0277565 R-DDI-5694423 https://reactome.org/PathwayBrowser/#/R-DDI-5694423 NSF and SNAPs bind cis-SNARE complex IEA Dictyostelium discoideum DDB_G0277565 R-DDI-5694425 https://reactome.org/PathwayBrowser/#/R-DDI-5694425 NSF ATPase activity dissociates cis-SNARE IEA Dictyostelium discoideum DDB_G0277565 R-DDI-5694439 https://reactome.org/PathwayBrowser/#/R-DDI-5694439 COPII coat binds TRAPPCII and RAB1:GDP IEA Dictyostelium discoideum DDB_G0277565 R-DDI-5694441 https://reactome.org/PathwayBrowser/#/R-DDI-5694441 CSNK1D phosphorylates SEC23 IEA Dictyostelium discoideum DDB_G0277565 R-DDI-5694522 https://reactome.org/PathwayBrowser/#/R-DDI-5694522 Inner coat assembly and cargo binding IEA Dictyostelium discoideum DDB_G0277565 R-DDI-5694527 https://reactome.org/PathwayBrowser/#/R-DDI-5694527 Loss of SAR1B GTPase IEA Dictyostelium discoideum DDB_G0277565 R-DDI-6809011 https://reactome.org/PathwayBrowser/#/R-DDI-6809011 cis-Golgi t-SNAREs bind YKT6 on tethered vesicle IEA Dictyostelium discoideum DDB_G0277565 R-DDI-6809014 https://reactome.org/PathwayBrowser/#/R-DDI-6809014 cis-Golgi cis-SNARE binds NSF and SNAPs IEA Dictyostelium discoideum DDB_G0277565 R-DDI-6809015 https://reactome.org/PathwayBrowser/#/R-DDI-6809015 NSF ATPase activity dissociates cis-SNARE at cis-Golgi IEA Dictyostelium discoideum DDB_G0277565 R-DDI-6811433 https://reactome.org/PathwayBrowser/#/R-DDI-6811433 The COG tethering complex interacts with numerous SNAREs at the Golgi membrane IEA Dictyostelium discoideum DDB_G0277565 R-DDI-8847637 https://reactome.org/PathwayBrowser/#/R-DDI-8847637 NSF and SNAPs bind the cis-SNARE at the Golgi IEA Dictyostelium discoideum DDB_G0277565 R-DDI-8847638 https://reactome.org/PathwayBrowser/#/R-DDI-8847638 ATP hydrolysis by NSF disassembles the cis-SNARE at the Golgi membrane IEA Dictyostelium discoideum DDB_G0277565 R-DDI-9609921 https://reactome.org/PathwayBrowser/#/R-DDI-9609921 SGTA binds Tail-anchored protein IEA Dictyostelium discoideum DDB_G0277569 R-DDI-2046088 https://reactome.org/PathwayBrowser/#/R-DDI-2046088 Elongation of stearidonoyl-CoA to eicosatetraenoyl-CoA IEA Dictyostelium discoideum DDB_G0277569 R-DDI-2046094 https://reactome.org/PathwayBrowser/#/R-DDI-2046094 Elongation of gamma-lenolenoyl-CoA to dihomo-gamma-lenolenoyl-CoA IEA Dictyostelium discoideum DDB_G0277569 R-DDI-548800 https://reactome.org/PathwayBrowser/#/R-DDI-548800 ELOVL1,2,3,5 elongate AA-CoA and Mal-CoA to 3ODCT-CoA IEA Dictyostelium discoideum DDB_G0277569 R-DDI-548814 https://reactome.org/PathwayBrowser/#/R-DDI-548814 ELOVL3,6,7 elongate PALM-CoA and Mal-CoA to 3OOD-CoA IEA Dictyostelium discoideum DDB_G0277629 R-DDI-156826 https://reactome.org/PathwayBrowser/#/R-DDI-156826 Dissociation of L13a from the 60s ribosomal subunit IEA Dictyostelium discoideum DDB_G0277629 R-DDI-1799332 https://reactome.org/PathwayBrowser/#/R-DDI-1799332 Nascent polypeptide:mRNA:ribosome complex binds signal recognition particle (SRP) IEA Dictyostelium discoideum DDB_G0277629 R-DDI-72671 https://reactome.org/PathwayBrowser/#/R-DDI-72671 eIF5B:GTP is hydrolyzed and released IEA Dictyostelium discoideum DDB_G0277629 R-DDI-72672 https://reactome.org/PathwayBrowser/#/R-DDI-72672 The 60S subunit joins the translation initiation complex IEA Dictyostelium discoideum DDB_G0277629 R-DDI-72673 https://reactome.org/PathwayBrowser/#/R-DDI-72673 Release of 40S and 60S subunits from the 80S ribosome IEA Dictyostelium discoideum DDB_G0277629 R-DDI-927789 https://reactome.org/PathwayBrowser/#/R-DDI-927789 Formation of UPF1:eRF3 complex on mRNA with a premature termination codon and no Exon Junction Complex IEA Dictyostelium discoideum DDB_G0277629 R-DDI-927832 https://reactome.org/PathwayBrowser/#/R-DDI-927832 UPF1 binds an mRNP with a termination codon preceding an Exon Junction Complex IEA Dictyostelium discoideum DDB_G0277629 R-DDI-927889 https://reactome.org/PathwayBrowser/#/R-DDI-927889 SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex) IEA Dictyostelium discoideum DDB_G0277635 R-DDI-156823 https://reactome.org/PathwayBrowser/#/R-DDI-156823 Association of phospho-L13a with GAIT element of Ceruloplasmin mRNA IEA Dictyostelium discoideum DDB_G0277635 R-DDI-1799332 https://reactome.org/PathwayBrowser/#/R-DDI-1799332 Nascent polypeptide:mRNA:ribosome complex binds signal recognition particle (SRP) IEA Dictyostelium discoideum DDB_G0277635 R-DDI-72621 https://reactome.org/PathwayBrowser/#/R-DDI-72621 Ribosomal scanning IEA Dictyostelium discoideum DDB_G0277635 R-DDI-72671 https://reactome.org/PathwayBrowser/#/R-DDI-72671 eIF5B:GTP is hydrolyzed and released IEA Dictyostelium discoideum DDB_G0277635 R-DDI-72672 https://reactome.org/PathwayBrowser/#/R-DDI-72672 The 60S subunit joins the translation initiation complex IEA Dictyostelium discoideum DDB_G0277635 R-DDI-72673 https://reactome.org/PathwayBrowser/#/R-DDI-72673 Release of 40S and 60S subunits from the 80S ribosome IEA Dictyostelium discoideum DDB_G0277635 R-DDI-72676 https://reactome.org/PathwayBrowser/#/R-DDI-72676 eIF3 and eIF1A bind to the 40S subunit IEA Dictyostelium discoideum DDB_G0277635 R-DDI-72691 https://reactome.org/PathwayBrowser/#/R-DDI-72691 Formation of the 43S pre-initiation complex IEA Dictyostelium discoideum DDB_G0277635 R-DDI-72697 https://reactome.org/PathwayBrowser/#/R-DDI-72697 Start codon recognition IEA Dictyostelium discoideum DDB_G0277635 R-DDI-927789 https://reactome.org/PathwayBrowser/#/R-DDI-927789 Formation of UPF1:eRF3 complex on mRNA with a premature termination codon and no Exon Junction Complex IEA Dictyostelium discoideum DDB_G0277635 R-DDI-927832 https://reactome.org/PathwayBrowser/#/R-DDI-927832 UPF1 binds an mRNP with a termination codon preceding an Exon Junction Complex IEA Dictyostelium discoideum DDB_G0277635 R-DDI-927889 https://reactome.org/PathwayBrowser/#/R-DDI-927889 SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex) IEA Dictyostelium discoideum DDB_G0277671 R-DDI-76056 https://reactome.org/PathwayBrowser/#/R-DDI-76056 Recruitment of RNA polymerase III to TFIIIB:TFIIIC:TFIIIA:Type 1 Promoter Complex IEA Dictyostelium discoideum DDB_G0277671 R-DDI-83805 https://reactome.org/PathwayBrowser/#/R-DDI-83805 Recruitment of RNA Polymerase III to the TFIIIB:TFIIIC: Type 2 Promoter Complex IEA Dictyostelium discoideum DDB_G0277675 R-DDI-5658424 https://reactome.org/PathwayBrowser/#/R-DDI-5658424 KBTBD7:CUL3:RBX1 ubiquitinates NF1 IEA Dictyostelium discoideum DDB_G0277675 R-DDI-5658430 https://reactome.org/PathwayBrowser/#/R-DDI-5658430 NF1 is degraded by the proteasome IEA Dictyostelium discoideum DDB_G0277675 R-DDI-5658438 https://reactome.org/PathwayBrowser/#/R-DDI-5658438 SPRED dimer binds NF1 IEA Dictyostelium discoideum DDB_G0277677 R-DDI-109638 https://reactome.org/PathwayBrowser/#/R-DDI-109638 Recruitment of RNA Polymerase II Holoenzyme by TFIIF to the pol II promoter:TFIID:TFIIA:TFIIB complex IEA Dictyostelium discoideum DDB_G0277677 R-DDI-109639 https://reactome.org/PathwayBrowser/#/R-DDI-109639 Formation of the closed pre-initiation complex IEA Dictyostelium discoideum DDB_G0277677 R-DDI-111264 https://reactome.org/PathwayBrowser/#/R-DDI-111264 Addition of nucleotides between position +11 and +30 IEA Dictyostelium discoideum DDB_G0277677 R-DDI-112383 https://reactome.org/PathwayBrowser/#/R-DDI-112383 Hypophosphorylation of RNA Pol II CTD by FCP1P protein IEA Dictyostelium discoideum DDB_G0277677 R-DDI-113407 https://reactome.org/PathwayBrowser/#/R-DDI-113407 DSIF complex binds to RNA Pol II (hypophosphorylated) IEA Dictyostelium discoideum DDB_G0277677 R-DDI-113409 https://reactome.org/PathwayBrowser/#/R-DDI-113409 Abortive termination of early transcription elongation by DSIF:NELF IEA Dictyostelium discoideum DDB_G0277677 R-DDI-113430 https://reactome.org/PathwayBrowser/#/R-DDI-113430 Extrusion of 5'-end of 30 nt long transcript through the pore in Pol II complex IEA Dictyostelium discoideum DDB_G0277677 R-DDI-6781818 https://reactome.org/PathwayBrowser/#/R-DDI-6781818 RNA Pol II initiates transcription from damaged DNA template IEA Dictyostelium discoideum DDB_G0277677 R-DDI-6781824 https://reactome.org/PathwayBrowser/#/R-DDI-6781824 Active RNA Pol II complex transcribes lesion-containing DNA template IEA Dictyostelium discoideum DDB_G0277677 R-DDI-6781833 https://reactome.org/PathwayBrowser/#/R-DDI-6781833 ERCC8 (CSA) binds stalled RNA Pol II IEA Dictyostelium discoideum DDB_G0277677 R-DDI-6781840 https://reactome.org/PathwayBrowser/#/R-DDI-6781840 ERCC6 binds stalled RNA Pol II IEA Dictyostelium discoideum DDB_G0277677 R-DDI-6781867 https://reactome.org/PathwayBrowser/#/R-DDI-6781867 ERCC8:DDB1:CUL4:RBX1 ubiquitinates ERCC6 and RNA Pol II IEA Dictyostelium discoideum DDB_G0277677 R-DDI-6782069 https://reactome.org/PathwayBrowser/#/R-DDI-6782069 UVSSA:USP7 deubiquitinates ERCC6 IEA Dictyostelium discoideum DDB_G0277677 R-DDI-6782131 https://reactome.org/PathwayBrowser/#/R-DDI-6782131 ERCC2-facilitated RNA Pol II backtracking in TC-NER IEA Dictyostelium discoideum DDB_G0277677 R-DDI-6782141 https://reactome.org/PathwayBrowser/#/R-DDI-6782141 Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in TC-NER IEA Dictyostelium discoideum DDB_G0277677 R-DDI-6782204 https://reactome.org/PathwayBrowser/#/R-DDI-6782204 5' incision of damaged DNA strand by ERCC1:ERCC4 in TC-NER IEA Dictyostelium discoideum DDB_G0277677 R-DDI-6782208 https://reactome.org/PathwayBrowser/#/R-DDI-6782208 Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in TC-NER IEA Dictyostelium discoideum DDB_G0277677 R-DDI-6782211 https://reactome.org/PathwayBrowser/#/R-DDI-6782211 DNA polymerases delta, epsilon or kappa bind the TC-NER site IEA Dictyostelium discoideum DDB_G0277677 R-DDI-6782227 https://reactome.org/PathwayBrowser/#/R-DDI-6782227 Ligation of newly synthesized repair patch to incised DNA in TC-NER IEA Dictyostelium discoideum DDB_G0277677 R-DDI-6797606 https://reactome.org/PathwayBrowser/#/R-DDI-6797606 CDK12 phosphorylates RNA Pol II CTD at DNA repair genes IEA Dictyostelium discoideum DDB_G0277677 R-DDI-6797616 https://reactome.org/PathwayBrowser/#/R-DDI-6797616 CCNK:CDK12 binds RNA Pol II at DNA repair genes IEA Dictyostelium discoideum DDB_G0277677 R-DDI-6810233 https://reactome.org/PathwayBrowser/#/R-DDI-6810233 CDK7 phosphorylates serine-5 and serine-7 of heptad repeats in C-terminal domain of RNA polymerase II at snRNA promoter IEA Dictyostelium discoideum DDB_G0277677 R-DDI-6810238 https://reactome.org/PathwayBrowser/#/R-DDI-6810238 RNA polymerase II binds initiation factors at promoter of snRNA gene (U1, U2, U4, U4atac, U5, U11, U12) IEA Dictyostelium discoideum DDB_G0277677 R-DDI-6814555 https://reactome.org/PathwayBrowser/#/R-DDI-6814555 Integrator complex processes the 3' end of snRNA IEA Dictyostelium discoideum DDB_G0277677 R-DDI-6814559 https://reactome.org/PathwayBrowser/#/R-DDI-6814559 Pre-snRNA is elongated and capped with 7-methylguanosine IEA Dictyostelium discoideum DDB_G0277677 R-DDI-72103 https://reactome.org/PathwayBrowser/#/R-DDI-72103 Formation of pre-mRNPs IEA Dictyostelium discoideum DDB_G0277677 R-DDI-73946 https://reactome.org/PathwayBrowser/#/R-DDI-73946 Abortive initiation after formation of the first phosphodiester bond IEA Dictyostelium discoideum DDB_G0277677 R-DDI-75095 https://reactome.org/PathwayBrowser/#/R-DDI-75095 Binding of TFIIE to the growing preinitiation complex IEA Dictyostelium discoideum DDB_G0277677 R-DDI-75850 https://reactome.org/PathwayBrowser/#/R-DDI-75850 Addition of the third nucleotide on the nascent transcript IEA Dictyostelium discoideum DDB_G0277677 R-DDI-75856 https://reactome.org/PathwayBrowser/#/R-DDI-75856 Abortive Initiation Before Second Transition IEA Dictyostelium discoideum DDB_G0277677 R-DDI-75861 https://reactome.org/PathwayBrowser/#/R-DDI-75861 NTP Binds Active Site of RNA Polymerase II IEA Dictyostelium discoideum DDB_G0277677 R-DDI-75862 https://reactome.org/PathwayBrowser/#/R-DDI-75862 Fall Back to Closed Pre-initiation Complex IEA Dictyostelium discoideum DDB_G0277677 R-DDI-75864 https://reactome.org/PathwayBrowser/#/R-DDI-75864 Newly Formed Phosphodiester Bond Stabilized and PPi Released IEA Dictyostelium discoideum DDB_G0277677 R-DDI-75866 https://reactome.org/PathwayBrowser/#/R-DDI-75866 Nucleophillic Attack by 3'-hydroxyl Oxygen of nascent transcript on the Alpha Phosphate of NTP IEA Dictyostelium discoideum DDB_G0277677 R-DDI-75869 https://reactome.org/PathwayBrowser/#/R-DDI-75869 Addition of the fourth nucleotide on the Nascent Transcript: Second Transition IEA Dictyostelium discoideum DDB_G0277677 R-DDI-75873 https://reactome.org/PathwayBrowser/#/R-DDI-75873 Addition of Nucleotides 5 through 9 on the growing Transcript IEA Dictyostelium discoideum DDB_G0277677 R-DDI-75891 https://reactome.org/PathwayBrowser/#/R-DDI-75891 Abortive Initiation After Second Transition IEA Dictyostelium discoideum DDB_G0277677 R-DDI-75949 https://reactome.org/PathwayBrowser/#/R-DDI-75949 RNA Polymerase II Promoter Opening: First Transition IEA Dictyostelium discoideum DDB_G0277677 R-DDI-76576 https://reactome.org/PathwayBrowser/#/R-DDI-76576 Addition of nucleotides 10 and 11 on the growing transcript: Third Transition IEA Dictyostelium discoideum DDB_G0277677 R-DDI-77068 https://reactome.org/PathwayBrowser/#/R-DDI-77068 Activation of GT IEA Dictyostelium discoideum DDB_G0277677 R-DDI-77069 https://reactome.org/PathwayBrowser/#/R-DDI-77069 RNA Polymerase II CTD (phosphorylated) binds to CE IEA Dictyostelium discoideum DDB_G0277677 R-DDI-77071 https://reactome.org/PathwayBrowser/#/R-DDI-77071 Phosphorylation (Ser5) of RNA pol II CTD IEA Dictyostelium discoideum DDB_G0277677 R-DDI-77073 https://reactome.org/PathwayBrowser/#/R-DDI-77073 SPT5 subunit of Pol II binds the RNA triphosphatase (RTP) IEA Dictyostelium discoideum DDB_G0277677 R-DDI-77077 https://reactome.org/PathwayBrowser/#/R-DDI-77077 Capping complex formation IEA Dictyostelium discoideum DDB_G0277677 R-DDI-77078 https://reactome.org/PathwayBrowser/#/R-DDI-77078 Hydrolysis of the 5'-end of the nascent transcript by the capping enzyme IEA Dictyostelium discoideum DDB_G0277677 R-DDI-77081 https://reactome.org/PathwayBrowser/#/R-DDI-77081 Formation of the CE:GMP intermediate complex IEA Dictyostelium discoideum DDB_G0277677 R-DDI-77083 https://reactome.org/PathwayBrowser/#/R-DDI-77083 Transfer of GMP from the capping enzyme GT site to 5'-end of mRNA IEA Dictyostelium discoideum DDB_G0277677 R-DDI-77085 https://reactome.org/PathwayBrowser/#/R-DDI-77085 Dissociation of transcript with 5'-GMP from GT IEA Dictyostelium discoideum DDB_G0277677 R-DDI-77090 https://reactome.org/PathwayBrowser/#/R-DDI-77090 Methylation of GMP-cap by RNA Methyltransferase IEA Dictyostelium discoideum DDB_G0277677 R-DDI-77095 https://reactome.org/PathwayBrowser/#/R-DDI-77095 Recognition and binding of the mRNA cap by the cap-binding complex IEA Dictyostelium discoideum DDB_G0277677 R-DDI-9012319 https://reactome.org/PathwayBrowser/#/R-DDI-9012319 p-TEFb phosphorylates serine 2 in RNA polymerase II CTD IEA Dictyostelium discoideum DDB_G0277677 R-DDI-9613494 https://reactome.org/PathwayBrowser/#/R-DDI-9613494 Unwinding of DNA for the Nascent Transcript: Second Transition IEA Dictyostelium discoideum DDB_G0277677 R-DDI-9613497 https://reactome.org/PathwayBrowser/#/R-DDI-9613497 Unwinding DNA for the nascent transcript IEA Dictyostelium discoideum DDB_G0277677 R-DDI-9684118 https://reactome.org/PathwayBrowser/#/R-DDI-9684118 ERCC3-facilitated RNA Pol II backtracking in TC-NER IEA Dictyostelium discoideum DDB_G0277677 R-DDI-9770236 https://reactome.org/PathwayBrowser/#/R-DDI-9770236 Formation of the Spliceosomal P complex and exon ligation IEA Dictyostelium discoideum DDB_G0277691 R-DDI-6809011 https://reactome.org/PathwayBrowser/#/R-DDI-6809011 cis-Golgi t-SNAREs bind YKT6 on tethered vesicle IEA Dictyostelium discoideum DDB_G0277691 R-DDI-6811433 https://reactome.org/PathwayBrowser/#/R-DDI-6811433 The COG tethering complex interacts with numerous SNAREs at the Golgi membrane IEA Dictyostelium discoideum DDB_G0277691 R-DDI-8849748 https://reactome.org/PathwayBrowser/#/R-DDI-8849748 The COG complex binds RABs at the Golgi membrane IEA Dictyostelium discoideum DDB_G0277699 R-DDI-8948039 https://reactome.org/PathwayBrowser/#/R-DDI-8948039 FUNDC1 is phosphorylated by CK2 IEA Dictyostelium discoideum DDB_G0277699 R-DDI-8948146 https://reactome.org/PathwayBrowser/#/R-DDI-8948146 FUNDC1 is phosphorylated by ULK1 at Ser17 IEA Dictyostelium discoideum DDB_G0277699 R-DDI-8959571 https://reactome.org/PathwayBrowser/#/R-DDI-8959571 LC3 binds the autophagosome membrane Atg5-Atg12 complex IEA Dictyostelium discoideum DDB_G0277699 R-DDI-8959573 https://reactome.org/PathwayBrowser/#/R-DDI-8959573 Phosphorylated FUNDC1 links damaged mitochondria to LC3 IEA Dictyostelium discoideum DDB_G0277701 R-DDI-110349 https://reactome.org/PathwayBrowser/#/R-DDI-110349 Displacement of UNG glycosylase by APEX1 at the AP site IEA Dictyostelium discoideum DDB_G0277701 R-DDI-110352 https://reactome.org/PathwayBrowser/#/R-DDI-110352 Displacement of NTHL1 glycosylase by APEX1 at the AP site IEA Dictyostelium discoideum DDB_G0277701 R-DDI-110354 https://reactome.org/PathwayBrowser/#/R-DDI-110354 Displacement of OGG1 glycosylase by APEX1 at the AP site IEA Dictyostelium discoideum DDB_G0277701 R-DDI-110355 https://reactome.org/PathwayBrowser/#/R-DDI-110355 Displacement of MUTYH glycosylase by APEX1 at the AP site IEA Dictyostelium discoideum DDB_G0277701 R-DDI-110359 https://reactome.org/PathwayBrowser/#/R-DDI-110359 APEX1 mediates endonucleolytic cleavage at the 5' side of the AP site IEA Dictyostelium discoideum DDB_G0277701 R-DDI-110360 https://reactome.org/PathwayBrowser/#/R-DDI-110360 Recruitment of POLB to the AP site IEA Dictyostelium discoideum DDB_G0277701 R-DDI-110364 https://reactome.org/PathwayBrowser/#/R-DDI-110364 PCNA:POLD,POLE:RPA:RFC and FEN1 bind APEX1 IEA Dictyostelium discoideum DDB_G0277701 R-DDI-110368 https://reactome.org/PathwayBrowser/#/R-DDI-110368 POLD,POLE-mediated DNA strand displacement synthesis IEA Dictyostelium discoideum DDB_G0277701 R-DDI-110371 https://reactome.org/PathwayBrowser/#/R-DDI-110371 LIG1 binds APEX1 and PCNA at SSB IEA Dictyostelium discoideum DDB_G0277701 R-DDI-110375 https://reactome.org/PathwayBrowser/#/R-DDI-110375 Excision of the abasic sugar phosphate (5'dRP) residue at the single strand break IEA Dictyostelium discoideum DDB_G0277701 R-DDI-111253 https://reactome.org/PathwayBrowser/#/R-DDI-111253 POLB incorporates the first 3' dNMP and displaces 5'ddRP at SSB site IEA Dictyostelium discoideum DDB_G0277701 R-DDI-5649854 https://reactome.org/PathwayBrowser/#/R-DDI-5649854 Recruitment of POLB to oxidatively damaged AP site IEA Dictyostelium discoideum DDB_G0277701 R-DDI-5649856 https://reactome.org/PathwayBrowser/#/R-DDI-5649856 Oxidative damage to the AP site IEA Dictyostelium discoideum DDB_G0277701 R-DDI-5649873 https://reactome.org/PathwayBrowser/#/R-DDI-5649873 PARP1,PARP2 dimers and FEN1 bind POLB and displace APEX1 from damaged AP site IEA Dictyostelium discoideum DDB_G0277701 R-DDI-5651805 https://reactome.org/PathwayBrowser/#/R-DDI-5651805 LIG1 bound to APEX1 and PCNA ligates SSB IEA Dictyostelium discoideum DDB_G0277723 R-DDI-6789310 https://reactome.org/PathwayBrowser/#/R-DDI-6789310 LIPs hydrolyse TG to DAG and RCOOH IEA Dictyostelium discoideum DDB_G0277723 R-DDI-8979996 https://reactome.org/PathwayBrowser/#/R-DDI-8979996 LIPs hydrolyze TG to DAG and LCFA IEA Dictyostelium discoideum DDB_G0277727 R-DDI-70903 https://reactome.org/PathwayBrowser/#/R-DDI-70903 urocanate + H2O => 4-imidazolone-5-propionate IEA Dictyostelium discoideum DDB_G0277743 R-DDI-74255 https://reactome.org/PathwayBrowser/#/R-DDI-74255 Guanine + H2O => Xanthine + NH4+ IEA Dictyostelium discoideum DDB_G0277749 R-DDI-376419 https://reactome.org/PathwayBrowser/#/R-DDI-376419 Formation of NR-MED1 Coactivator Complex IEA Dictyostelium discoideum DDB_G0277761 R-DDI-9014641 https://reactome.org/PathwayBrowser/#/R-DDI-9014641 HRSP12 deaminates 2AA to 2OBUTA IEA Dictyostelium discoideum DDB_G0277773 R-DDI-189222 https://reactome.org/PathwayBrowser/#/R-DDI-189222 SLC2A5 transports fructose from extracellular region to cytosol IEA Dictyostelium discoideum DDB_G0277773 R-DDI-189242 https://reactome.org/PathwayBrowser/#/R-DDI-189242 SLC2A2 tetramer transports Fru, Gal, Glc from cytosol to extracellular region IEA Dictyostelium discoideum DDB_G0277773 R-DDI-198818 https://reactome.org/PathwayBrowser/#/R-DDI-198818 SLC2A1,3 transports DeHA from extracellular region to cytosol IEA Dictyostelium discoideum DDB_G0277773 R-DDI-428779 https://reactome.org/PathwayBrowser/#/R-DDI-428779 GLUT7 and GLUT11 transport glucose and fructose IEA Dictyostelium discoideum DDB_G0277773 R-DDI-429036 https://reactome.org/PathwayBrowser/#/R-DDI-429036 SLC2A9 transports Fru, Glc, urate IEA Dictyostelium discoideum DDB_G0277773 R-DDI-450088 https://reactome.org/PathwayBrowser/#/R-DDI-450088 GLUT1 tetramer binds 4xATP IEA Dictyostelium discoideum DDB_G0277773 R-DDI-450092 https://reactome.org/PathwayBrowser/#/R-DDI-450092 GLUT1:ATP tetramer dissociates to GLUT1 tetramer and 4xATP IEA Dictyostelium discoideum DDB_G0277773 R-DDI-450095 https://reactome.org/PathwayBrowser/#/R-DDI-450095 GLUT2 (SLC2A2) transports Glc from cytosol to extracellular region IEA Dictyostelium discoideum DDB_G0277773 R-DDI-499981 https://reactome.org/PathwayBrowser/#/R-DDI-499981 Transport of Extracellular Glucose to the Cytosol by GLUT1 and GLUT2 IEA Dictyostelium discoideum DDB_G0277773 R-DDI-5339524 https://reactome.org/PathwayBrowser/#/R-DDI-5339524 GLUT1 (SLC2A1) tetramer transports Glc from extracellular region to cytosol IEA Dictyostelium discoideum DDB_G0277773 R-DDI-5653873 https://reactome.org/PathwayBrowser/#/R-DDI-5653873 SLC2A1 tetramer transports Glc from cytosol to Golgi lumen IEA Dictyostelium discoideum DDB_G0277773 R-DDI-6799350 https://reactome.org/PathwayBrowser/#/R-DDI-6799350 Exocytosis of specific granule membrane proteins IEA Dictyostelium discoideum DDB_G0277773 R-DDI-8981553 https://reactome.org/PathwayBrowser/#/R-DDI-8981553 GLUT14 (SLC2A14) tetramer transports Glc from extracellular region to cytosol IEA Dictyostelium discoideum DDB_G0277773 R-DDI-8981570 https://reactome.org/PathwayBrowser/#/R-DDI-8981570 GLUT4 (SLC2A4) tetramer transports Glc from extracellular region to cytosol IEA Dictyostelium discoideum DDB_G0277773 R-DDI-8981574 https://reactome.org/PathwayBrowser/#/R-DDI-8981574 GLUT2 (SLC2A2) tetramer transports Glc from extracellular region to cytosol IEA Dictyostelium discoideum DDB_G0277777 R-DDI-8870489 https://reactome.org/PathwayBrowser/#/R-DDI-8870489 PLEKHA4,(5,6) bind PI3P IEA Dictyostelium discoideum DDB_G0277791 R-DDI-6798743 https://reactome.org/PathwayBrowser/#/R-DDI-6798743 Exocytosis of secretory granule membrane proteins IEA Dictyostelium discoideum DDB_G0277791 R-DDI-9014293 https://reactome.org/PathwayBrowser/#/R-DDI-9014293 RAC2 GDIs block activation of RAC2 IEA Dictyostelium discoideum DDB_G0277791 R-DDI-9014294 https://reactome.org/PathwayBrowser/#/R-DDI-9014294 RAC2 binds effectors at the plasma membrane IEA Dictyostelium discoideum DDB_G0277791 R-DDI-9014295 https://reactome.org/PathwayBrowser/#/R-DDI-9014295 RAC2 GAPs stimulate RAC2 GTPase activity IEA Dictyostelium discoideum DDB_G0277791 R-DDI-9014296 https://reactome.org/PathwayBrowser/#/R-DDI-9014296 RAC2 GEFs activate RAC2 IEA Dictyostelium discoideum DDB_G0277791 R-DDI-9014420 https://reactome.org/PathwayBrowser/#/R-DDI-9014420 RAC2 translocates to the phagocytic vesicle membrane IEA Dictyostelium discoideum DDB_G0277791 R-DDI-9014433 https://reactome.org/PathwayBrowser/#/R-DDI-9014433 RHOG GEFs activate RHOG IEA Dictyostelium discoideum DDB_G0277791 R-DDI-9014449 https://reactome.org/PathwayBrowser/#/R-DDI-9014449 RHOG binds effectors at the plasma membrane IEA Dictyostelium discoideum DDB_G0277791 R-DDI-9014454 https://reactome.org/PathwayBrowser/#/R-DDI-9014454 RHOG translocates to the ER membrane IEA Dictyostelium discoideum DDB_G0277791 R-DDI-9014456 https://reactome.org/PathwayBrowser/#/R-DDI-9014456 GDIs block activation of RHOG IEA Dictyostelium discoideum DDB_G0277791 R-DDI-9018754 https://reactome.org/PathwayBrowser/#/R-DDI-9018754 GDIs bind RHOH IEA Dictyostelium discoideum DDB_G0277791 R-DDI-9018756 https://reactome.org/PathwayBrowser/#/R-DDI-9018756 RHOH binds GTP IEA Dictyostelium discoideum DDB_G0277791 R-DDI-9018758 https://reactome.org/PathwayBrowser/#/R-DDI-9018758 RHOH binds effectors at the plasma membrane IEA Dictyostelium discoideum DDB_G0277791 R-DDI-9018774 https://reactome.org/PathwayBrowser/#/R-DDI-9018774 RHOBTB1 binds GTP IEA Dictyostelium discoideum DDB_G0277791 R-DDI-9018778 https://reactome.org/PathwayBrowser/#/R-DDI-9018778 RHOBTB1 binds interacting proteins at the endosome membrane IEA Dictyostelium discoideum DDB_G0277791 R-DDI-9018787 https://reactome.org/PathwayBrowser/#/R-DDI-9018787 RHOBTB2 binds interacting proteins at the endosome membrane IEA Dictyostelium discoideum DDB_G0277791 R-DDI-9714477 https://reactome.org/PathwayBrowser/#/R-DDI-9714477 RAC2 binds effectors at the mitochondrial outer membrane IEA Dictyostelium discoideum DDB_G0277791 R-DDI-9714480 https://reactome.org/PathwayBrowser/#/R-DDI-9714480 RAC2 translocates to the mitochondrial membrane IEA Dictyostelium discoideum DDB_G0277791 R-DDI-9714483 https://reactome.org/PathwayBrowser/#/R-DDI-9714483 RAC2 translocates to the ER membrane IEA Dictyostelium discoideum DDB_G0277797 R-DDI-203979 https://reactome.org/PathwayBrowser/#/R-DDI-203979 Coat Assembly IEA Dictyostelium discoideum DDB_G0277797 R-DDI-204008 https://reactome.org/PathwayBrowser/#/R-DDI-204008 SEC31:SEC13 and v-SNARE recruitment IEA Dictyostelium discoideum DDB_G0277797 R-DDI-5694409 https://reactome.org/PathwayBrowser/#/R-DDI-5694409 Nucleotide exchange on RAB1 IEA Dictyostelium discoideum DDB_G0277797 R-DDI-5694413 https://reactome.org/PathwayBrowser/#/R-DDI-5694413 SEC4C,D bind GOSR2 and STX5 IEA Dictyostelium discoideum DDB_G0277797 R-DDI-5694421 https://reactome.org/PathwayBrowser/#/R-DDI-5694421 PP6 dephosphorylates SEC24 IEA Dictyostelium discoideum DDB_G0277797 R-DDI-5694439 https://reactome.org/PathwayBrowser/#/R-DDI-5694439 COPII coat binds TRAPPCII and RAB1:GDP IEA Dictyostelium discoideum DDB_G0277797 R-DDI-5694441 https://reactome.org/PathwayBrowser/#/R-DDI-5694441 CSNK1D phosphorylates SEC23 IEA Dictyostelium discoideum DDB_G0277797 R-DDI-5694522 https://reactome.org/PathwayBrowser/#/R-DDI-5694522 Inner coat assembly and cargo binding IEA Dictyostelium discoideum DDB_G0277797 R-DDI-5694527 https://reactome.org/PathwayBrowser/#/R-DDI-5694527 Loss of SAR1B GTPase IEA Dictyostelium discoideum DDB_G0277803 R-DDI-156826 https://reactome.org/PathwayBrowser/#/R-DDI-156826 Dissociation of L13a from the 60s ribosomal subunit IEA Dictyostelium discoideum DDB_G0277803 R-DDI-1799332 https://reactome.org/PathwayBrowser/#/R-DDI-1799332 Nascent polypeptide:mRNA:ribosome complex binds signal recognition particle (SRP) IEA Dictyostelium discoideum DDB_G0277803 R-DDI-72671 https://reactome.org/PathwayBrowser/#/R-DDI-72671 eIF5B:GTP is hydrolyzed and released IEA Dictyostelium discoideum DDB_G0277803 R-DDI-72672 https://reactome.org/PathwayBrowser/#/R-DDI-72672 The 60S subunit joins the translation initiation complex IEA Dictyostelium discoideum DDB_G0277803 R-DDI-72673 https://reactome.org/PathwayBrowser/#/R-DDI-72673 Release of 40S and 60S subunits from the 80S ribosome IEA Dictyostelium discoideum DDB_G0277803 R-DDI-927789 https://reactome.org/PathwayBrowser/#/R-DDI-927789 Formation of UPF1:eRF3 complex on mRNA with a premature termination codon and no Exon Junction Complex IEA Dictyostelium discoideum DDB_G0277803 R-DDI-927832 https://reactome.org/PathwayBrowser/#/R-DDI-927832 UPF1 binds an mRNP with a termination codon preceding an Exon Junction Complex IEA Dictyostelium discoideum DDB_G0277803 R-DDI-927889 https://reactome.org/PathwayBrowser/#/R-DDI-927889 SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex) IEA Dictyostelium discoideum DDB_G0277815 R-DDI-449911 https://reactome.org/PathwayBrowser/#/R-DDI-449911 acetate + CoA + ATP => acetyl-CoA + AMP + pyrophosphate [mitochondrial] IEA Dictyostelium discoideum DDB_G0277815 R-DDI-5688289 https://reactome.org/PathwayBrowser/#/R-DDI-5688289 SIRT3 deacetylates ACCS2, GLUD, IDH2, SOD2 IEA Dictyostelium discoideum DDB_G0277815 R-DDI-71735 https://reactome.org/PathwayBrowser/#/R-DDI-71735 acetate + CoA + ATP => acetyl-CoA + AMP + pyrophosphate [cytosolic] IEA Dictyostelium discoideum DDB_G0277825 R-DDI-2029466 https://reactome.org/PathwayBrowser/#/R-DDI-2029466 (WASPs, WAVE):G-actin:ARP2/3 binds F-actin IEA Dictyostelium discoideum DDB_G0277825 R-DDI-2029473 https://reactome.org/PathwayBrowser/#/R-DDI-2029473 Branching and elongation of mother and daughter filaments IEA Dictyostelium discoideum DDB_G0277825 R-DDI-2197690 https://reactome.org/PathwayBrowser/#/R-DDI-2197690 Detachment of WASP/WAVE IEA Dictyostelium discoideum DDB_G0277835 R-DDI-376357 https://reactome.org/PathwayBrowser/#/R-DDI-376357 Vamp7 associated Lysosome to Plasma membrane transport IEA Dictyostelium discoideum DDB_G0277835 R-DDI-376364 https://reactome.org/PathwayBrowser/#/R-DDI-376364 Vamp8 associated secretory vesicle to plasma membrane transport IEA Dictyostelium discoideum DDB_G0277835 R-DDI-376369 https://reactome.org/PathwayBrowser/#/R-DDI-376369 Vamp2 associated secretory vesicle to plasma membrane transport IEA Dictyostelium discoideum DDB_G0277835 R-DDI-449117 https://reactome.org/PathwayBrowser/#/R-DDI-449117 TXLNA (IL14) binds syntaxin1A IEA Dictyostelium discoideum DDB_G0277835 R-DDI-6798747 https://reactome.org/PathwayBrowser/#/R-DDI-6798747 Exocytosis of tertiary granule membrane proteins IEA Dictyostelium discoideum DDB_G0277835 R-DDI-6799350 https://reactome.org/PathwayBrowser/#/R-DDI-6799350 Exocytosis of specific granule membrane proteins IEA Dictyostelium discoideum DDB_G0277835 R-DDI-9013145 https://reactome.org/PathwayBrowser/#/R-DDI-9013145 RAC1 binds effectors at the plasma membrane IEA Dictyostelium discoideum DDB_G0277835 R-DDI-9018746 https://reactome.org/PathwayBrowser/#/R-DDI-9018746 RHOQ binds effectors at the plasma membrane IEA Dictyostelium discoideum DDB_G0277835 R-DDI-9018808 https://reactome.org/PathwayBrowser/#/R-DDI-9018808 RAC3 binds effectors at the plasma membrane IEA Dictyostelium discoideum DDB_G0277847 R-DDI-9858752 https://reactome.org/PathwayBrowser/#/R-DDI-9858752 LIPT1 transfers lipoyl group from lipoyl-GCSH to DLAT IEA Dictyostelium discoideum DDB_G0277847 R-DDI-9861616 https://reactome.org/PathwayBrowser/#/R-DDI-9861616 DLD dimer dehydrogenates dihydrolipoyl IEA Dictyostelium discoideum DDB_G0277847 R-DDI-9861667 https://reactome.org/PathwayBrowser/#/R-DDI-9861667 DLAT trimer transfers acetyl to CoA IEA Dictyostelium discoideum DDB_G0277847 R-DDI-9861734 https://reactome.org/PathwayBrowser/#/R-DDI-9861734 PDH E1 decarboxylates PYR, transferring acetyl to DLAT IEA Dictyostelium discoideum DDB_G0277849 R-DDI-1169406 https://reactome.org/PathwayBrowser/#/R-DDI-1169406 ISGylation of host proteins IEA Dictyostelium discoideum DDB_G0277849 R-DDI-351948 https://reactome.org/PathwayBrowser/#/R-DDI-351948 Mitochondrial recruitment of Drp1 IEA Dictyostelium discoideum DDB_G0277849 R-DDI-8867344 https://reactome.org/PathwayBrowser/#/R-DDI-8867344 OMA1 hydrolyses OPA1 IEA Dictyostelium discoideum DDB_G0277851 R-DDI-1169406 https://reactome.org/PathwayBrowser/#/R-DDI-1169406 ISGylation of host proteins IEA Dictyostelium discoideum DDB_G0277851 R-DDI-8867344 https://reactome.org/PathwayBrowser/#/R-DDI-8867344 OMA1 hydrolyses OPA1 IEA Dictyostelium discoideum DDB_G0277859 R-DDI-5668932 https://reactome.org/PathwayBrowser/#/R-DDI-5668932 PAK2 phosphorylates myosin regulatory light chain (MRLC) IEA Dictyostelium discoideum DDB_G0277861 R-DDI-418309 https://reactome.org/PathwayBrowser/#/R-DDI-418309 ATP2B1-4 transport cytosolic Ca2+ to extracellular region IEA Dictyostelium discoideum DDB_G0277861 R-DDI-5617178 https://reactome.org/PathwayBrowser/#/R-DDI-5617178 ATP2B4 binds to NOS1, inhibiting it IEA Dictyostelium discoideum DDB_G0277865 R-DDI-6798743 https://reactome.org/PathwayBrowser/#/R-DDI-6798743 Exocytosis of secretory granule membrane proteins IEA Dictyostelium discoideum DDB_G0277865 R-DDI-6799350 https://reactome.org/PathwayBrowser/#/R-DDI-6799350 Exocytosis of specific granule membrane proteins IEA Dictyostelium discoideum DDB_G0277865 R-DDI-9635739 https://reactome.org/PathwayBrowser/#/R-DDI-9635739 PTPN7 dephosphorylates p-T,Y-MAPKs IEA Dictyostelium discoideum DDB_G0277865 R-DDI-9635743 https://reactome.org/PathwayBrowser/#/R-DDI-9635743 PTPN7 binds p-T,Y-MAPK IEA Dictyostelium discoideum DDB_G0277867 R-DDI-2214351 https://reactome.org/PathwayBrowser/#/R-DDI-2214351 PLK1 phosphorylates GORASP1 IEA Dictyostelium discoideum DDB_G0277867 R-DDI-5694409 https://reactome.org/PathwayBrowser/#/R-DDI-5694409 Nucleotide exchange on RAB1 IEA Dictyostelium discoideum DDB_G0277867 R-DDI-5694439 https://reactome.org/PathwayBrowser/#/R-DDI-5694439 COPII coat binds TRAPPCII and RAB1:GDP IEA Dictyostelium discoideum DDB_G0277867 R-DDI-5694441 https://reactome.org/PathwayBrowser/#/R-DDI-5694441 CSNK1D phosphorylates SEC23 IEA Dictyostelium discoideum DDB_G0277867 R-DDI-6807864 https://reactome.org/PathwayBrowser/#/R-DDI-6807864 RAB1:GTP recruits GBF1 to the ERGIC IEA Dictyostelium discoideum DDB_G0277867 R-DDI-6807866 https://reactome.org/PathwayBrowser/#/R-DDI-6807866 GBF1 recruits ARF:GDP to the ERGIC IEA Dictyostelium discoideum DDB_G0277867 R-DDI-6807868 https://reactome.org/PathwayBrowser/#/R-DDI-6807868 GBF1 stimulates ARF nucleotide exchange IEA Dictyostelium discoideum DDB_G0277867 R-DDI-6807872 https://reactome.org/PathwayBrowser/#/R-DDI-6807872 Active ARF recruits coatomer IEA Dictyostelium discoideum DDB_G0277867 R-DDI-6807875 https://reactome.org/PathwayBrowser/#/R-DDI-6807875 ARFGAP, cargo, v-SNAREs and p24 proteins bind nascent COPI complex IEA Dictyostelium discoideum DDB_G0277867 R-DDI-6807877 https://reactome.org/PathwayBrowser/#/R-DDI-6807877 ARFGAPs stimulate ARF GTPase activity IEA Dictyostelium discoideum DDB_G0277867 R-DDI-6809003 https://reactome.org/PathwayBrowser/#/R-DDI-6809003 ERGIC-to-Golgi vesicles bind dynein:dynactin IEA Dictyostelium discoideum DDB_G0277867 R-DDI-6809011 https://reactome.org/PathwayBrowser/#/R-DDI-6809011 cis-Golgi t-SNAREs bind YKT6 on tethered vesicle IEA Dictyostelium discoideum DDB_G0277867 R-DDI-6811411 https://reactome.org/PathwayBrowser/#/R-DDI-6811411 GBF1 recruits ARF:GDP to the Golgi IEA Dictyostelium discoideum DDB_G0277867 R-DDI-6811412 https://reactome.org/PathwayBrowser/#/R-DDI-6811412 Active ARF recruits coatomer to the Golgi IEA Dictyostelium discoideum DDB_G0277867 R-DDI-6811414 https://reactome.org/PathwayBrowser/#/R-DDI-6811414 GBF1 stimulates nucleotide exchange on ARF IEA Dictyostelium discoideum DDB_G0277867 R-DDI-6811415 https://reactome.org/PathwayBrowser/#/R-DDI-6811415 RAB:GTP recruits GBF1 to the Golgi membrane IEA Dictyostelium discoideum DDB_G0277867 R-DDI-6811417 https://reactome.org/PathwayBrowser/#/R-DDI-6811417 ARFGAP, cargo, vSNARES and p24 proteins bind COPI vesicles at Golgi IEA Dictyostelium discoideum DDB_G0277867 R-DDI-6811418 https://reactome.org/PathwayBrowser/#/R-DDI-6811418 ARFGAPs stimulate ARF GTPase activity at the Golgi membrane IEA Dictyostelium discoideum DDB_G0277867 R-DDI-6811427 https://reactome.org/PathwayBrowser/#/R-DDI-6811427 COPI vesicle uncoating at the ER IEA Dictyostelium discoideum DDB_G0277867 R-DDI-6814831 https://reactome.org/PathwayBrowser/#/R-DDI-6814831 TBC1D20 binds RAB1:GTP IEA Dictyostelium discoideum DDB_G0277867 R-DDI-6814833 https://reactome.org/PathwayBrowser/#/R-DDI-6814833 TBC1D20 stimulates GTPase activity of RAB1, resulting in hydrolysis of GTP IEA Dictyostelium discoideum DDB_G0277867 R-DDI-8847534 https://reactome.org/PathwayBrowser/#/R-DDI-8847534 RAB43 hydrolyses GTP IEA Dictyostelium discoideum DDB_G0277867 R-DDI-8847537 https://reactome.org/PathwayBrowser/#/R-DDI-8847537 RAB43:GTP binds USP8NL IEA Dictyostelium discoideum DDB_G0277867 R-DDI-8870466 https://reactome.org/PathwayBrowser/#/R-DDI-8870466 RGGT:CHM binds RABs IEA Dictyostelium discoideum DDB_G0277867 R-DDI-8870469 https://reactome.org/PathwayBrowser/#/R-DDI-8870469 RGGT geranylgeranylates RAB proteins IEA Dictyostelium discoideum DDB_G0277867 R-DDI-8877475 https://reactome.org/PathwayBrowser/#/R-DDI-8877475 TRAPPC complexes exchange GTP for GDP on RAB1 IEA Dictyostelium discoideum DDB_G0277869 R-DDI-1011598 https://reactome.org/PathwayBrowser/#/R-DDI-1011598 DOCKs bind to RhoGEFs IEA Dictyostelium discoideum DDB_G0277869 R-DDI-2029454 https://reactome.org/PathwayBrowser/#/R-DDI-2029454 Autophosphorylation of PAK1 IEA Dictyostelium discoideum DDB_G0277869 R-DDI-2029456 https://reactome.org/PathwayBrowser/#/R-DDI-2029456 RAC1 and CDC42 activate PAK1 IEA Dictyostelium discoideum DDB_G0277869 R-DDI-2029466 https://reactome.org/PathwayBrowser/#/R-DDI-2029466 (WASPs, WAVE):G-actin:ARP2/3 binds F-actin IEA Dictyostelium discoideum DDB_G0277869 R-DDI-2029469 https://reactome.org/PathwayBrowser/#/R-DDI-2029469 p-ERK phosphorylates WAVEs and ABI IEA Dictyostelium discoideum DDB_G0277869 R-DDI-205039 https://reactome.org/PathwayBrowser/#/R-DDI-205039 p75NTR indirectly activates RAC and Cdc42 via a guanyl-nucleotide exchange factor IEA Dictyostelium discoideum DDB_G0277869 R-DDI-205136 https://reactome.org/PathwayBrowser/#/R-DDI-205136 GTP-bound RAC contributes to JNK activation IEA Dictyostelium discoideum DDB_G0277869 R-DDI-2197690 https://reactome.org/PathwayBrowser/#/R-DDI-2197690 Detachment of WASP/WAVE IEA Dictyostelium discoideum DDB_G0277869 R-DDI-389788 https://reactome.org/PathwayBrowser/#/R-DDI-389788 Activation of PAKs by RAC1 and CDC42 IEA Dictyostelium discoideum DDB_G0277869 R-DDI-3928619 https://reactome.org/PathwayBrowser/#/R-DDI-3928619 PAK1 binds RAC1:GTP IEA Dictyostelium discoideum DDB_G0277869 R-DDI-3928620 https://reactome.org/PathwayBrowser/#/R-DDI-3928620 PAK1 autophosphorylates IEA Dictyostelium discoideum DDB_G0277869 R-DDI-445072 https://reactome.org/PathwayBrowser/#/R-DDI-445072 Interaction of PAK1 with Rac1-GTP IEA Dictyostelium discoideum DDB_G0277869 R-DDI-5626469 https://reactome.org/PathwayBrowser/#/R-DDI-5626469 GTP-bound RAC1 and CDC42 bind IQGAPs IEA Dictyostelium discoideum DDB_G0277869 R-DDI-5626507 https://reactome.org/PathwayBrowser/#/R-DDI-5626507 IQGAPs bind F-actin, which is inhibited by calmodulin IEA Dictyostelium discoideum DDB_G0277869 R-DDI-5626549 https://reactome.org/PathwayBrowser/#/R-DDI-5626549 IQGAPs bind CALM1 IEA Dictyostelium discoideum DDB_G0277869 R-DDI-5627775 https://reactome.org/PathwayBrowser/#/R-DDI-5627775 Autophosphorylation of PAK1,2,3 IEA Dictyostelium discoideum DDB_G0277869 R-DDI-5672329 https://reactome.org/PathwayBrowser/#/R-DDI-5672329 IQGAP1 binds CLIP1 and microtubules IEA Dictyostelium discoideum DDB_G0277869 R-DDI-6798743 https://reactome.org/PathwayBrowser/#/R-DDI-6798743 Exocytosis of secretory granule membrane proteins IEA Dictyostelium discoideum DDB_G0277869 R-DDI-6800426 https://reactome.org/PathwayBrowser/#/R-DDI-6800426 Exocytosis of ficolin-rich granule membrane proteins IEA Dictyostelium discoideum DDB_G0277869 R-DDI-8848618 https://reactome.org/PathwayBrowser/#/R-DDI-8848618 Activation of RAC1 by the PXN:CRK complex IEA Dictyostelium discoideum DDB_G0277869 R-DDI-8981926 https://reactome.org/PathwayBrowser/#/R-DDI-8981926 RAC1 and CDC42 activate PAK3 IEA Dictyostelium discoideum DDB_G0277869 R-DDI-8981931 https://reactome.org/PathwayBrowser/#/R-DDI-8981931 RAC1 and CDC42 activate PAK2 IEA Dictyostelium discoideum DDB_G0277869 R-DDI-9013143 https://reactome.org/PathwayBrowser/#/R-DDI-9013143 RAC1 GEFs activate RAC1 IEA Dictyostelium discoideum DDB_G0277869 R-DDI-9013144 https://reactome.org/PathwayBrowser/#/R-DDI-9013144 RAC1 GAPs stimulate RAC1 GTPase activity IEA Dictyostelium discoideum DDB_G0277869 R-DDI-9013145 https://reactome.org/PathwayBrowser/#/R-DDI-9013145 RAC1 binds effectors at the plasma membrane IEA Dictyostelium discoideum DDB_G0277869 R-DDI-9013147 https://reactome.org/PathwayBrowser/#/R-DDI-9013147 RAC1 GDIs block activation of RAC1 IEA Dictyostelium discoideum DDB_G0277869 R-DDI-9014293 https://reactome.org/PathwayBrowser/#/R-DDI-9014293 RAC2 GDIs block activation of RAC2 IEA Dictyostelium discoideum DDB_G0277869 R-DDI-9014294 https://reactome.org/PathwayBrowser/#/R-DDI-9014294 RAC2 binds effectors at the plasma membrane IEA Dictyostelium discoideum DDB_G0277869 R-DDI-9014295 https://reactome.org/PathwayBrowser/#/R-DDI-9014295 RAC2 GAPs stimulate RAC2 GTPase activity IEA Dictyostelium discoideum DDB_G0277869 R-DDI-9014296 https://reactome.org/PathwayBrowser/#/R-DDI-9014296 RAC2 GEFs activate RAC2 IEA Dictyostelium discoideum DDB_G0277869 R-DDI-9014420 https://reactome.org/PathwayBrowser/#/R-DDI-9014420 RAC2 translocates to the phagocytic vesicle membrane IEA Dictyostelium discoideum DDB_G0277869 R-DDI-9014433 https://reactome.org/PathwayBrowser/#/R-DDI-9014433 RHOG GEFs activate RHOG IEA Dictyostelium discoideum DDB_G0277869 R-DDI-9014449 https://reactome.org/PathwayBrowser/#/R-DDI-9014449 RHOG binds effectors at the plasma membrane IEA Dictyostelium discoideum DDB_G0277869 R-DDI-9014454 https://reactome.org/PathwayBrowser/#/R-DDI-9014454 RHOG translocates to the ER membrane IEA Dictyostelium discoideum DDB_G0277869 R-DDI-9014456 https://reactome.org/PathwayBrowser/#/R-DDI-9014456 GDIs block activation of RHOG IEA Dictyostelium discoideum DDB_G0277869 R-DDI-9018754 https://reactome.org/PathwayBrowser/#/R-DDI-9018754 GDIs bind RHOH IEA Dictyostelium discoideum DDB_G0277869 R-DDI-9018756 https://reactome.org/PathwayBrowser/#/R-DDI-9018756 RHOH binds GTP IEA Dictyostelium discoideum DDB_G0277869 R-DDI-9018758 https://reactome.org/PathwayBrowser/#/R-DDI-9018758 RHOH binds effectors at the plasma membrane IEA Dictyostelium discoideum DDB_G0277869 R-DDI-9018774 https://reactome.org/PathwayBrowser/#/R-DDI-9018774 RHOBTB1 binds GTP IEA Dictyostelium discoideum DDB_G0277869 R-DDI-9018778 https://reactome.org/PathwayBrowser/#/R-DDI-9018778 RHOBTB1 binds interacting proteins at the endosome membrane IEA Dictyostelium discoideum DDB_G0277869 R-DDI-9018787 https://reactome.org/PathwayBrowser/#/R-DDI-9018787 RHOBTB2 binds interacting proteins at the endosome membrane IEA Dictyostelium discoideum DDB_G0277869 R-DDI-9018804 https://reactome.org/PathwayBrowser/#/R-DDI-9018804 RAC3 GEFs activate RAC3 IEA Dictyostelium discoideum DDB_G0277869 R-DDI-9018806 https://reactome.org/PathwayBrowser/#/R-DDI-9018806 RAC3 GAPs stimulate RAC3 GTPase activity IEA Dictyostelium discoideum DDB_G0277869 R-DDI-9018807 https://reactome.org/PathwayBrowser/#/R-DDI-9018807 RAC3 GDIs block activation of RAC3 IEA Dictyostelium discoideum DDB_G0277869 R-DDI-9018808 https://reactome.org/PathwayBrowser/#/R-DDI-9018808 RAC3 binds effectors at the plasma membrane IEA Dictyostelium discoideum DDB_G0277869 R-DDI-9691168 https://reactome.org/PathwayBrowser/#/R-DDI-9691168 RAC1 translocates to the endoplasmic reticulum membrane IEA Dictyostelium discoideum DDB_G0277869 R-DDI-9714477 https://reactome.org/PathwayBrowser/#/R-DDI-9714477 RAC2 binds effectors at the mitochondrial outer membrane IEA Dictyostelium discoideum DDB_G0277869 R-DDI-9714480 https://reactome.org/PathwayBrowser/#/R-DDI-9714480 RAC2 translocates to the mitochondrial membrane IEA Dictyostelium discoideum DDB_G0277869 R-DDI-9714483 https://reactome.org/PathwayBrowser/#/R-DDI-9714483 RAC2 translocates to the ER membrane IEA Dictyostelium discoideum DDB_G0277869 R-DDI-9714694 https://reactome.org/PathwayBrowser/#/R-DDI-9714694 RAC3 translocates to the endoplasmic reticulum membrane IEA Dictyostelium discoideum DDB_G0277877 R-DDI-110215 https://reactome.org/PathwayBrowser/#/R-DDI-110215 Cleavage of uracil by UNG glycosylase IEA Dictyostelium discoideum DDB_G0277877 R-DDI-110217 https://reactome.org/PathwayBrowser/#/R-DDI-110217 Cleavage of 5-hydroxyluracil by UNG glycosylase IEA Dictyostelium discoideum DDB_G0277877 R-DDI-110349 https://reactome.org/PathwayBrowser/#/R-DDI-110349 Displacement of UNG glycosylase by APEX1 at the AP site IEA Dictyostelium discoideum DDB_G0277879 R-DDI-70286 https://reactome.org/PathwayBrowser/#/R-DDI-70286 UTP + D-glucose 1-phosphate <=> pyrophosphate + UDP-glucose IEA Dictyostelium discoideum DDB_G0277885 R-DDI-71299 https://reactome.org/PathwayBrowser/#/R-DDI-71299 6-phospho-D-gluconate + NADP+ => D-ribulose 5-phosphate + CO2 + NADPH + H+ IEA Dictyostelium discoideum DDB_G0277897 R-DDI-6798743 https://reactome.org/PathwayBrowser/#/R-DDI-6798743 Exocytosis of secretory granule membrane proteins IEA Dictyostelium discoideum DDB_G0277897 R-DDI-9014293 https://reactome.org/PathwayBrowser/#/R-DDI-9014293 RAC2 GDIs block activation of RAC2 IEA Dictyostelium discoideum DDB_G0277897 R-DDI-9014294 https://reactome.org/PathwayBrowser/#/R-DDI-9014294 RAC2 binds effectors at the plasma membrane IEA Dictyostelium discoideum DDB_G0277897 R-DDI-9014295 https://reactome.org/PathwayBrowser/#/R-DDI-9014295 RAC2 GAPs stimulate RAC2 GTPase activity IEA Dictyostelium discoideum DDB_G0277897 R-DDI-9014296 https://reactome.org/PathwayBrowser/#/R-DDI-9014296 RAC2 GEFs activate RAC2 IEA Dictyostelium discoideum DDB_G0277897 R-DDI-9014420 https://reactome.org/PathwayBrowser/#/R-DDI-9014420 RAC2 translocates to the phagocytic vesicle membrane IEA Dictyostelium discoideum DDB_G0277897 R-DDI-9014433 https://reactome.org/PathwayBrowser/#/R-DDI-9014433 RHOG GEFs activate RHOG IEA Dictyostelium discoideum DDB_G0277897 R-DDI-9014449 https://reactome.org/PathwayBrowser/#/R-DDI-9014449 RHOG binds effectors at the plasma membrane IEA Dictyostelium discoideum DDB_G0277897 R-DDI-9014454 https://reactome.org/PathwayBrowser/#/R-DDI-9014454 RHOG translocates to the ER membrane IEA Dictyostelium discoideum DDB_G0277897 R-DDI-9014456 https://reactome.org/PathwayBrowser/#/R-DDI-9014456 GDIs block activation of RHOG IEA Dictyostelium discoideum DDB_G0277897 R-DDI-9018754 https://reactome.org/PathwayBrowser/#/R-DDI-9018754 GDIs bind RHOH IEA Dictyostelium discoideum DDB_G0277897 R-DDI-9018756 https://reactome.org/PathwayBrowser/#/R-DDI-9018756 RHOH binds GTP IEA Dictyostelium discoideum DDB_G0277897 R-DDI-9018758 https://reactome.org/PathwayBrowser/#/R-DDI-9018758 RHOH binds effectors at the plasma membrane IEA Dictyostelium discoideum DDB_G0277897 R-DDI-9018774 https://reactome.org/PathwayBrowser/#/R-DDI-9018774 RHOBTB1 binds GTP IEA Dictyostelium discoideum DDB_G0277897 R-DDI-9018778 https://reactome.org/PathwayBrowser/#/R-DDI-9018778 RHOBTB1 binds interacting proteins at the endosome membrane IEA Dictyostelium discoideum DDB_G0277897 R-DDI-9018787 https://reactome.org/PathwayBrowser/#/R-DDI-9018787 RHOBTB2 binds interacting proteins at the endosome membrane IEA Dictyostelium discoideum DDB_G0277897 R-DDI-9714477 https://reactome.org/PathwayBrowser/#/R-DDI-9714477 RAC2 binds effectors at the mitochondrial outer membrane IEA Dictyostelium discoideum DDB_G0277897 R-DDI-9714480 https://reactome.org/PathwayBrowser/#/R-DDI-9714480 RAC2 translocates to the mitochondrial membrane IEA Dictyostelium discoideum DDB_G0277897 R-DDI-9714483 https://reactome.org/PathwayBrowser/#/R-DDI-9714483 RAC2 translocates to the ER membrane IEA Dictyostelium discoideum DDB_G0277905 R-DDI-163664 https://reactome.org/PathwayBrowser/#/R-DDI-163664 AMP binds to gamma subunit of AMP kinase heterotrimer IEA Dictyostelium discoideum DDB_G0277905 R-DDI-200423 https://reactome.org/PathwayBrowser/#/R-DDI-200423 pAMPK inactivates ACACB, inhibiting malonyl-CoA synthesis IEA Dictyostelium discoideum DDB_G0277905 R-DDI-380930 https://reactome.org/PathwayBrowser/#/R-DDI-380930 Phosphorylated AMPK binds AMP IEA Dictyostelium discoideum DDB_G0277905 R-DDI-447074 https://reactome.org/PathwayBrowser/#/R-DDI-447074 AMPK phosphorylates Raptor in the mTORC1 complex IEA Dictyostelium discoideum DDB_G0277905 R-DDI-5631941 https://reactome.org/PathwayBrowser/#/R-DDI-5631941 SESN1,2,3 bind AMPK IEA Dictyostelium discoideum DDB_G0277905 R-DDI-5665868 https://reactome.org/PathwayBrowser/#/R-DDI-5665868 AMPK (complex) phosphorylates ULK1 (complex) IEA Dictyostelium discoideum DDB_G0277905 R-DDI-5672008 https://reactome.org/PathwayBrowser/#/R-DDI-5672008 Thr-180 of ULK1 is phosphorylated IEA Dictyostelium discoideum DDB_G0277905 R-DDI-5672011 https://reactome.org/PathwayBrowser/#/R-DDI-5672011 p-AMPK:AMP binds the ULK complex IEA Dictyostelium discoideum DDB_G0277905 R-DDI-5673768 https://reactome.org/PathwayBrowser/#/R-DDI-5673768 p-AMPK:AMP phosphorylates Raptor in the MTORC1 complex IEA Dictyostelium discoideum DDB_G0277905 R-DDI-5675868 https://reactome.org/PathwayBrowser/#/R-DDI-5675868 ULK1 phosphorylates ATG13 and RB1CC1 IEA Dictyostelium discoideum DDB_G0277905 R-DDI-5679205 https://reactome.org/PathwayBrowser/#/R-DDI-5679205 ULK1 phosphorylates Beclin-1 IEA Dictyostelium discoideum DDB_G0277905 R-DDI-5679239 https://reactome.org/PathwayBrowser/#/R-DDI-5679239 ULK complex translocates to the ER IEA Dictyostelium discoideum DDB_G0277907 R-DDI-156826 https://reactome.org/PathwayBrowser/#/R-DDI-156826 Dissociation of L13a from the 60s ribosomal subunit IEA Dictyostelium discoideum DDB_G0277907 R-DDI-1799332 https://reactome.org/PathwayBrowser/#/R-DDI-1799332 Nascent polypeptide:mRNA:ribosome complex binds signal recognition particle (SRP) IEA Dictyostelium discoideum DDB_G0277907 R-DDI-72671 https://reactome.org/PathwayBrowser/#/R-DDI-72671 eIF5B:GTP is hydrolyzed and released IEA Dictyostelium discoideum DDB_G0277907 R-DDI-72672 https://reactome.org/PathwayBrowser/#/R-DDI-72672 The 60S subunit joins the translation initiation complex IEA Dictyostelium discoideum DDB_G0277907 R-DDI-72673 https://reactome.org/PathwayBrowser/#/R-DDI-72673 Release of 40S and 60S subunits from the 80S ribosome IEA Dictyostelium discoideum DDB_G0277907 R-DDI-927789 https://reactome.org/PathwayBrowser/#/R-DDI-927789 Formation of UPF1:eRF3 complex on mRNA with a premature termination codon and no Exon Junction Complex IEA Dictyostelium discoideum DDB_G0277907 R-DDI-927832 https://reactome.org/PathwayBrowser/#/R-DDI-927832 UPF1 binds an mRNP with a termination codon preceding an Exon Junction Complex IEA Dictyostelium discoideum DDB_G0277907 R-DDI-927889 https://reactome.org/PathwayBrowser/#/R-DDI-927889 SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex) IEA Dictyostelium discoideum DDB_G0277911 R-DDI-192331 https://reactome.org/PathwayBrowser/#/R-DDI-192331 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA (THCA-CoA) is hydrated to (24R, 25R) 3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA IEA Dictyostelium discoideum DDB_G0277911 R-DDI-193455 https://reactome.org/PathwayBrowser/#/R-DDI-193455 (24R, 25R) 3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA is oxidized to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-one-CoA IEA Dictyostelium discoideum DDB_G0277911 R-DDI-193508 https://reactome.org/PathwayBrowser/#/R-DDI-193508 (24R, 25R) 3alpha,7alpha,24-trihydroxy-5beta-cholestanoyl-CoA is oxidized to 3alpha,7alpha-dihydroxy-5beta-cholest-24-one-CoA IEA Dictyostelium discoideum DDB_G0277911 R-DDI-193535 https://reactome.org/PathwayBrowser/#/R-DDI-193535 25(S) 3alpha,7alpha-dihydroxy-5beta-cholest-24-enoyl-CoA is hydrated to (24R, 25R) 3alpha,7alpha,24-trihydroxy-5beta-cholestanoyl-CoA IEA Dictyostelium discoideum DDB_G0277911 R-DDI-2066778 https://reactome.org/PathwayBrowser/#/R-DDI-2066778 Hydration of delta2-tetracosaheptaenoyl-CoA to 3-hydroxy tetracosahexaenoyl-CoA IEA Dictyostelium discoideum DDB_G0277911 R-DDI-2066780 https://reactome.org/PathwayBrowser/#/R-DDI-2066780 Dehydrogenation of 3-hydroxy tetracosahexaenoyl-CoA IEA Dictyostelium discoideum DDB_G0277911 R-DDI-389986 https://reactome.org/PathwayBrowser/#/R-DDI-389986 trans-2,3-dehydropristanoyl-CoA + H2O => 3-hydroxypristanoyl-CoA IEA Dictyostelium discoideum DDB_G0277911 R-DDI-389995 https://reactome.org/PathwayBrowser/#/R-DDI-389995 3-hydroxypristanoyl-CoA + NAD+ => 3-ketoxypristanoyl-CoA + NADH + H+ IEA Dictyostelium discoideum DDB_G0277911 R-DDI-390251 https://reactome.org/PathwayBrowser/#/R-DDI-390251 HSD17B4 dehydrogenates 3-hydroxyhexacosanoyl-CoA IEA Dictyostelium discoideum DDB_G0277911 R-DDI-390252 https://reactome.org/PathwayBrowser/#/R-DDI-390252 HSD17B4 hydrates trans-2,3-dehydrohexacosanoyl-CoA IEA Dictyostelium discoideum DDB_G0277911 R-DDI-9033235 https://reactome.org/PathwayBrowser/#/R-DDI-9033235 Cargo of PEX5S,L translocates from the cytosol to the peroxisomal matrix IEA Dictyostelium discoideum DDB_G0277911 R-DDI-9033236 https://reactome.org/PathwayBrowser/#/R-DDI-9033236 PEX5S,L:Cargo binds PEX13:PEX14:PEX2:PEX10:PEX12 (Docking and Translocation Module) IEA Dictyostelium discoideum DDB_G0277913 R-DDI-205039 https://reactome.org/PathwayBrowser/#/R-DDI-205039 p75NTR indirectly activates RAC and Cdc42 via a guanyl-nucleotide exchange factor IEA Dictyostelium discoideum DDB_G0277913 R-DDI-9013143 https://reactome.org/PathwayBrowser/#/R-DDI-9013143 RAC1 GEFs activate RAC1 IEA Dictyostelium discoideum DDB_G0277913 R-DDI-9013159 https://reactome.org/PathwayBrowser/#/R-DDI-9013159 CDC42 GEFs activate CDC42 IEA Dictyostelium discoideum DDB_G0277915 R-DDI-205039 https://reactome.org/PathwayBrowser/#/R-DDI-205039 p75NTR indirectly activates RAC and Cdc42 via a guanyl-nucleotide exchange factor IEA Dictyostelium discoideum DDB_G0277915 R-DDI-9013143 https://reactome.org/PathwayBrowser/#/R-DDI-9013143 RAC1 GEFs activate RAC1 IEA Dictyostelium discoideum DDB_G0277915 R-DDI-9013159 https://reactome.org/PathwayBrowser/#/R-DDI-9013159 CDC42 GEFs activate CDC42 IEA Dictyostelium discoideum DDB_G0277917 R-DDI-111915 https://reactome.org/PathwayBrowser/#/R-DDI-111915 CAMK4 autophosphorylates IEA Dictyostelium discoideum DDB_G0277917 R-DDI-111930 https://reactome.org/PathwayBrowser/#/R-DDI-111930 Adenylate cyclase produces cAMP IEA Dictyostelium discoideum DDB_G0277917 R-DDI-111956 https://reactome.org/PathwayBrowser/#/R-DDI-111956 Calmodulin activates Cam-PDE 1 IEA Dictyostelium discoideum DDB_G0277917 R-DDI-1497784 https://reactome.org/PathwayBrowser/#/R-DDI-1497784 The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle IEA Dictyostelium discoideum DDB_G0277917 R-DDI-1497796 https://reactome.org/PathwayBrowser/#/R-DDI-1497796 BH2 binding can lead to eNOS uncoupling IEA Dictyostelium discoideum DDB_G0277917 R-DDI-1497810 https://reactome.org/PathwayBrowser/#/R-DDI-1497810 Uncoupled eNOS favours the formation of superoxide IEA Dictyostelium discoideum DDB_G0277917 R-DDI-1855153 https://reactome.org/PathwayBrowser/#/R-DDI-1855153 I(1,4,5)P3 is phosphorylated to I(1,3,4,5)P4 by ITPKA/B/C in the cytosol IEA Dictyostelium discoideum DDB_G0277917 R-DDI-202111 https://reactome.org/PathwayBrowser/#/R-DDI-202111 AKT1 phosphorylates eNOS IEA Dictyostelium discoideum DDB_G0277917 R-DDI-202127 https://reactome.org/PathwayBrowser/#/R-DDI-202127 eNOS synthesizes NO IEA Dictyostelium discoideum DDB_G0277917 R-DDI-202137 https://reactome.org/PathwayBrowser/#/R-DDI-202137 AKT1 binds eNOS complex via HSP90 IEA Dictyostelium discoideum DDB_G0277917 R-DDI-2730867 https://reactome.org/PathwayBrowser/#/R-DDI-2730867 Translocation of CaN:CaM:NFAT to nucleus IEA Dictyostelium discoideum DDB_G0277917 R-DDI-2730872 https://reactome.org/PathwayBrowser/#/R-DDI-2730872 Activation of Calcineurin IEA Dictyostelium discoideum DDB_G0277917 R-DDI-4551465 https://reactome.org/PathwayBrowser/#/R-DDI-4551465 Translocation of NFATC1:CaN:CaM to nucleus IEA Dictyostelium discoideum DDB_G0277917 R-DDI-482772 https://reactome.org/PathwayBrowser/#/R-DDI-482772 Release of platelet cytosolic components IEA Dictyostelium discoideum DDB_G0277917 R-DDI-5626507 https://reactome.org/PathwayBrowser/#/R-DDI-5626507 IQGAPs bind F-actin, which is inhibited by calmodulin IEA Dictyostelium discoideum DDB_G0277917 R-DDI-5626549 https://reactome.org/PathwayBrowser/#/R-DDI-5626549 IQGAPs bind CALM1 IEA Dictyostelium discoideum DDB_G0277917 R-DDI-6800434 https://reactome.org/PathwayBrowser/#/R-DDI-6800434 Exocytosis of ficolin-rich granule lumen proteins IEA Dictyostelium discoideum DDB_G0277917 R-DDI-9619376 https://reactome.org/PathwayBrowser/#/R-DDI-9619376 CAMK1 binds calmodulin IEA Dictyostelium discoideum DDB_G0277919 R-DDI-6800138 https://reactome.org/PathwayBrowser/#/R-DDI-6800138 N6AMT1:TRMT112 transfers CH3 group from AdoMet to ETF1 dimer IEA Dictyostelium discoideum DDB_G0277919 R-DDI-927789 https://reactome.org/PathwayBrowser/#/R-DDI-927789 Formation of UPF1:eRF3 complex on mRNA with a premature termination codon and no Exon Junction Complex IEA Dictyostelium discoideum DDB_G0277919 R-DDI-927832 https://reactome.org/PathwayBrowser/#/R-DDI-927832 UPF1 binds an mRNP with a termination codon preceding an Exon Junction Complex IEA Dictyostelium discoideum DDB_G0277919 R-DDI-927889 https://reactome.org/PathwayBrowser/#/R-DDI-927889 SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex) IEA Dictyostelium discoideum DDB_G0277923 R-DDI-6807875 https://reactome.org/PathwayBrowser/#/R-DDI-6807875 ARFGAP, cargo, v-SNAREs and p24 proteins bind nascent COPI complex IEA Dictyostelium discoideum DDB_G0277923 R-DDI-6807877 https://reactome.org/PathwayBrowser/#/R-DDI-6807877 ARFGAPs stimulate ARF GTPase activity IEA Dictyostelium discoideum DDB_G0277923 R-DDI-6809003 https://reactome.org/PathwayBrowser/#/R-DDI-6809003 ERGIC-to-Golgi vesicles bind dynein:dynactin IEA Dictyostelium discoideum DDB_G0277923 R-DDI-6809011 https://reactome.org/PathwayBrowser/#/R-DDI-6809011 cis-Golgi t-SNAREs bind YKT6 on tethered vesicle IEA Dictyostelium discoideum DDB_G0277923 R-DDI-6811417 https://reactome.org/PathwayBrowser/#/R-DDI-6811417 ARFGAP, cargo, vSNARES and p24 proteins bind COPI vesicles at Golgi IEA Dictyostelium discoideum DDB_G0277923 R-DDI-6811418 https://reactome.org/PathwayBrowser/#/R-DDI-6811418 ARFGAPs stimulate ARF GTPase activity at the Golgi membrane IEA Dictyostelium discoideum DDB_G0277923 R-DDI-6811427 https://reactome.org/PathwayBrowser/#/R-DDI-6811427 COPI vesicle uncoating at the ER IEA Dictyostelium discoideum DDB_G0277927 R-DDI-5691381 https://reactome.org/PathwayBrowser/#/R-DDI-5691381 MYSM1 deubiquitinates Histone H2A IEA Dictyostelium discoideum DDB_G0277943 R-DDI-5649873 https://reactome.org/PathwayBrowser/#/R-DDI-5649873 PARP1,PARP2 dimers and FEN1 bind POLB and displace APEX1 from damaged AP site IEA Dictyostelium discoideum DDB_G0277943 R-DDI-5651828 https://reactome.org/PathwayBrowser/#/R-DDI-5651828 PARG dePARylates PARP1,PARP2 IEA Dictyostelium discoideum DDB_G0277945 R-DDI-6791219 https://reactome.org/PathwayBrowser/#/R-DDI-6791219 32S pre-rRNA is nucleolytically processed at site 4 (4a) to yield 12S pre-rRNA and 28S rRNA IEA Dictyostelium discoideum DDB_G0277947 R-DDI-200651 https://reactome.org/PathwayBrowser/#/R-DDI-200651 5,10-methyleneTHF polyglutamate + glycine <=> tetrahydrofolate polyglutamate (THF polyglutamate) + serine IEA Dictyostelium discoideum DDB_G0277947 R-DDI-200735 https://reactome.org/PathwayBrowser/#/R-DDI-200735 SHMT1 tetramer transfers hydroxymethyl group to THFPG to form 5,10-methylene-THFPG IEA Dictyostelium discoideum DDB_G0277947 R-DDI-5694137 https://reactome.org/PathwayBrowser/#/R-DDI-5694137 PXLP-K280-SHMT2 tetramer transfers CH2OH group to Gly to form L-Ser IEA Dictyostelium discoideum DDB_G0277947 R-DDI-71249 https://reactome.org/PathwayBrowser/#/R-DDI-71249 SHMT1 tetramer cleaves HTMLYS to yield TEABL and Gly IEA Dictyostelium discoideum DDB_G0277947 R-DDI-9014449 https://reactome.org/PathwayBrowser/#/R-DDI-9014449 RHOG binds effectors at the plasma membrane IEA Dictyostelium discoideum DDB_G0277947 R-DDI-9837978 https://reactome.org/PathwayBrowser/#/R-DDI-9837978 LONP1 binds mitochondrial inner membrane proteins IEA Dictyostelium discoideum DDB_G0277947 R-DDI-9838004 https://reactome.org/PathwayBrowser/#/R-DDI-9838004 LONP1 degrades mitochondrial inner membrane proteins IEA Dictyostelium discoideum DDB_G0277949 R-DDI-1483182 https://reactome.org/PathwayBrowser/#/R-DDI-1483182 PC is hydrolyzed to PA and choline by PLD1/2 IEA Dictyostelium discoideum DDB_G0277949 R-DDI-2029471 https://reactome.org/PathwayBrowser/#/R-DDI-2029471 Hydrolysis of PC to PA by PLD IEA Dictyostelium discoideum DDB_G0277949 R-DDI-6798747 https://reactome.org/PathwayBrowser/#/R-DDI-6798747 Exocytosis of tertiary granule membrane proteins IEA Dictyostelium discoideum DDB_G0277949 R-DDI-6799350 https://reactome.org/PathwayBrowser/#/R-DDI-6799350 Exocytosis of specific granule membrane proteins IEA Dictyostelium discoideum DDB_G0277949 R-DDI-9013145 https://reactome.org/PathwayBrowser/#/R-DDI-9013145 RAC1 binds effectors at the plasma membrane IEA Dictyostelium discoideum DDB_G0277949 R-DDI-9014294 https://reactome.org/PathwayBrowser/#/R-DDI-9014294 RAC2 binds effectors at the plasma membrane IEA Dictyostelium discoideum DDB_G0277949 R-DDI-9014449 https://reactome.org/PathwayBrowser/#/R-DDI-9014449 RHOG binds effectors at the plasma membrane IEA Dictyostelium discoideum DDB_G0277953 R-DDI-6814555 https://reactome.org/PathwayBrowser/#/R-DDI-6814555 Integrator complex processes the 3' end of snRNA IEA Dictyostelium discoideum DDB_G0277953 R-DDI-6814559 https://reactome.org/PathwayBrowser/#/R-DDI-6814559 Pre-snRNA is elongated and capped with 7-methylguanosine IEA Dictyostelium discoideum DDB_G0277967 R-DDI-6800426 https://reactome.org/PathwayBrowser/#/R-DDI-6800426 Exocytosis of ficolin-rich granule membrane proteins IEA Dictyostelium discoideum DDB_G0277967 R-DDI-8854173 https://reactome.org/PathwayBrowser/#/R-DDI-8854173 TBC RabGAPs accelerate GTP hydrolysis by RAB35 IEA Dictyostelium discoideum DDB_G0277967 R-DDI-8854209 https://reactome.org/PathwayBrowser/#/R-DDI-8854209 TBC1D10A binds JFC1 IEA Dictyostelium discoideum DDB_G0277971 R-DDI-1222516 https://reactome.org/PathwayBrowser/#/R-DDI-1222516 Intraphagosomal pH is lowered to 5 by V-ATPase IEA Dictyostelium discoideum DDB_G0277971 R-DDI-74723 https://reactome.org/PathwayBrowser/#/R-DDI-74723 Endosome acidification IEA Dictyostelium discoideum DDB_G0277971 R-DDI-917841 https://reactome.org/PathwayBrowser/#/R-DDI-917841 Acidification of Tf:TfR1 containing endosome IEA Dictyostelium discoideum DDB_G0277971 R-DDI-9639286 https://reactome.org/PathwayBrowser/#/R-DDI-9639286 RRAGC,D exchanges GTP for GDP IEA Dictyostelium discoideum DDB_G0277971 R-DDI-9640167 https://reactome.org/PathwayBrowser/#/R-DDI-9640167 RRAGA,B exchanges GDP for GTP IEA Dictyostelium discoideum DDB_G0277971 R-DDI-9640195 https://reactome.org/PathwayBrowser/#/R-DDI-9640195 RRAGA,B hydrolyzes GTP IEA Dictyostelium discoideum DDB_G0277971 R-DDI-9645598 https://reactome.org/PathwayBrowser/#/R-DDI-9645598 RRAGC,D hydrolyzes GTP IEA Dictyostelium discoideum DDB_G0277971 R-DDI-9645608 https://reactome.org/PathwayBrowser/#/R-DDI-9645608 v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP binds mTORC1 IEA Dictyostelium discoideum DDB_G0277971 R-DDI-9646468 https://reactome.org/PathwayBrowser/#/R-DDI-9646468 mTORC1 binds RHEB:GTP IEA Dictyostelium discoideum DDB_G0277975 R-DDI-156826 https://reactome.org/PathwayBrowser/#/R-DDI-156826 Dissociation of L13a from the 60s ribosomal subunit IEA Dictyostelium discoideum DDB_G0277975 R-DDI-1799332 https://reactome.org/PathwayBrowser/#/R-DDI-1799332 Nascent polypeptide:mRNA:ribosome complex binds signal recognition particle (SRP) IEA Dictyostelium discoideum DDB_G0277975 R-DDI-72671 https://reactome.org/PathwayBrowser/#/R-DDI-72671 eIF5B:GTP is hydrolyzed and released IEA Dictyostelium discoideum DDB_G0277975 R-DDI-72672 https://reactome.org/PathwayBrowser/#/R-DDI-72672 The 60S subunit joins the translation initiation complex IEA Dictyostelium discoideum DDB_G0277975 R-DDI-72673 https://reactome.org/PathwayBrowser/#/R-DDI-72673 Release of 40S and 60S subunits from the 80S ribosome IEA Dictyostelium discoideum DDB_G0277975 R-DDI-927789 https://reactome.org/PathwayBrowser/#/R-DDI-927789 Formation of UPF1:eRF3 complex on mRNA with a premature termination codon and no Exon Junction Complex IEA Dictyostelium discoideum DDB_G0277975 R-DDI-927832 https://reactome.org/PathwayBrowser/#/R-DDI-927832 UPF1 binds an mRNP with a termination codon preceding an Exon Junction Complex IEA Dictyostelium discoideum DDB_G0277975 R-DDI-927889 https://reactome.org/PathwayBrowser/#/R-DDI-927889 SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex) IEA Dictyostelium discoideum DDB_G0277977 R-DDI-6782069 https://reactome.org/PathwayBrowser/#/R-DDI-6782069 UVSSA:USP7 deubiquitinates ERCC6 IEA Dictyostelium discoideum DDB_G0277977 R-DDI-6782131 https://reactome.org/PathwayBrowser/#/R-DDI-6782131 ERCC2-facilitated RNA Pol II backtracking in TC-NER IEA Dictyostelium discoideum DDB_G0277977 R-DDI-6782141 https://reactome.org/PathwayBrowser/#/R-DDI-6782141 Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in TC-NER IEA Dictyostelium discoideum DDB_G0277977 R-DDI-6782204 https://reactome.org/PathwayBrowser/#/R-DDI-6782204 5' incision of damaged DNA strand by ERCC1:ERCC4 in TC-NER IEA Dictyostelium discoideum DDB_G0277977 R-DDI-6782208 https://reactome.org/PathwayBrowser/#/R-DDI-6782208 Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in TC-NER IEA Dictyostelium discoideum DDB_G0277977 R-DDI-6782211 https://reactome.org/PathwayBrowser/#/R-DDI-6782211 DNA polymerases delta, epsilon or kappa bind the TC-NER site IEA Dictyostelium discoideum DDB_G0277977 R-DDI-6782227 https://reactome.org/PathwayBrowser/#/R-DDI-6782227 Ligation of newly synthesized repair patch to incised DNA in TC-NER IEA Dictyostelium discoideum DDB_G0277977 R-DDI-9684118 https://reactome.org/PathwayBrowser/#/R-DDI-9684118 ERCC3-facilitated RNA Pol II backtracking in TC-NER IEA Dictyostelium discoideum DDB_G0277977 R-DDI-9770236 https://reactome.org/PathwayBrowser/#/R-DDI-9770236 Formation of the Spliceosomal P complex and exon ligation IEA Dictyostelium discoideum DDB_G0277991 R-DDI-169260 https://reactome.org/PathwayBrowser/#/R-DDI-169260 Reducing equivalents from beta-oxidation of fatty acids transfer to ETF IEA Dictyostelium discoideum DDB_G0277991 R-DDI-169270 https://reactome.org/PathwayBrowser/#/R-DDI-169270 ETFDH oxidises ETF (reduced) to ETF, reduces CoQ to CoQH2 IEA Dictyostelium discoideum DDB_G0277997 R-DDI-6811427 https://reactome.org/PathwayBrowser/#/R-DDI-6811427 COPI vesicle uncoating at the ER IEA Dictyostelium discoideum DDB_G0277999 R-DDI-8936442 https://reactome.org/PathwayBrowser/#/R-DDI-8936442 MARC1,MARC2 reduce N-hydroxylated compounds IEA Dictyostelium discoideum DDB_G0278009 R-DDI-6798743 https://reactome.org/PathwayBrowser/#/R-DDI-6798743 Exocytosis of secretory granule membrane proteins IEA Dictyostelium discoideum DDB_G0278009 R-DDI-9014293 https://reactome.org/PathwayBrowser/#/R-DDI-9014293 RAC2 GDIs block activation of RAC2 IEA Dictyostelium discoideum DDB_G0278009 R-DDI-9014294 https://reactome.org/PathwayBrowser/#/R-DDI-9014294 RAC2 binds effectors at the plasma membrane IEA Dictyostelium discoideum DDB_G0278009 R-DDI-9014295 https://reactome.org/PathwayBrowser/#/R-DDI-9014295 RAC2 GAPs stimulate RAC2 GTPase activity IEA Dictyostelium discoideum DDB_G0278009 R-DDI-9014296 https://reactome.org/PathwayBrowser/#/R-DDI-9014296 RAC2 GEFs activate RAC2 IEA Dictyostelium discoideum DDB_G0278009 R-DDI-9014420 https://reactome.org/PathwayBrowser/#/R-DDI-9014420 RAC2 translocates to the phagocytic vesicle membrane IEA Dictyostelium discoideum DDB_G0278009 R-DDI-9014433 https://reactome.org/PathwayBrowser/#/R-DDI-9014433 RHOG GEFs activate RHOG IEA Dictyostelium discoideum DDB_G0278009 R-DDI-9014449 https://reactome.org/PathwayBrowser/#/R-DDI-9014449 RHOG binds effectors at the plasma membrane IEA Dictyostelium discoideum DDB_G0278009 R-DDI-9014454 https://reactome.org/PathwayBrowser/#/R-DDI-9014454 RHOG translocates to the ER membrane IEA Dictyostelium discoideum DDB_G0278009 R-DDI-9014456 https://reactome.org/PathwayBrowser/#/R-DDI-9014456 GDIs block activation of RHOG IEA Dictyostelium discoideum DDB_G0278009 R-DDI-9018754 https://reactome.org/PathwayBrowser/#/R-DDI-9018754 GDIs bind RHOH IEA Dictyostelium discoideum DDB_G0278009 R-DDI-9018756 https://reactome.org/PathwayBrowser/#/R-DDI-9018756 RHOH binds GTP IEA Dictyostelium discoideum DDB_G0278009 R-DDI-9018758 https://reactome.org/PathwayBrowser/#/R-DDI-9018758 RHOH binds effectors at the plasma membrane IEA Dictyostelium discoideum DDB_G0278009 R-DDI-9018774 https://reactome.org/PathwayBrowser/#/R-DDI-9018774 RHOBTB1 binds GTP IEA Dictyostelium discoideum DDB_G0278009 R-DDI-9018778 https://reactome.org/PathwayBrowser/#/R-DDI-9018778 RHOBTB1 binds interacting proteins at the endosome membrane IEA Dictyostelium discoideum DDB_G0278009 R-DDI-9018787 https://reactome.org/PathwayBrowser/#/R-DDI-9018787 RHOBTB2 binds interacting proteins at the endosome membrane IEA Dictyostelium discoideum DDB_G0278009 R-DDI-9714477 https://reactome.org/PathwayBrowser/#/R-DDI-9714477 RAC2 binds effectors at the mitochondrial outer membrane IEA Dictyostelium discoideum DDB_G0278009 R-DDI-9714480 https://reactome.org/PathwayBrowser/#/R-DDI-9714480 RAC2 translocates to the mitochondrial membrane IEA Dictyostelium discoideum DDB_G0278009 R-DDI-9714483 https://reactome.org/PathwayBrowser/#/R-DDI-9714483 RAC2 translocates to the ER membrane IEA Dictyostelium discoideum DDB_G0278011 R-DDI-6798743 https://reactome.org/PathwayBrowser/#/R-DDI-6798743 Exocytosis of secretory granule membrane proteins IEA Dictyostelium discoideum DDB_G0278011 R-DDI-9014293 https://reactome.org/PathwayBrowser/#/R-DDI-9014293 RAC2 GDIs block activation of RAC2 IEA Dictyostelium discoideum DDB_G0278011 R-DDI-9014294 https://reactome.org/PathwayBrowser/#/R-DDI-9014294 RAC2 binds effectors at the plasma membrane IEA Dictyostelium discoideum DDB_G0278011 R-DDI-9014295 https://reactome.org/PathwayBrowser/#/R-DDI-9014295 RAC2 GAPs stimulate RAC2 GTPase activity IEA Dictyostelium discoideum DDB_G0278011 R-DDI-9014296 https://reactome.org/PathwayBrowser/#/R-DDI-9014296 RAC2 GEFs activate RAC2 IEA Dictyostelium discoideum DDB_G0278011 R-DDI-9014420 https://reactome.org/PathwayBrowser/#/R-DDI-9014420 RAC2 translocates to the phagocytic vesicle membrane IEA Dictyostelium discoideum DDB_G0278011 R-DDI-9014433 https://reactome.org/PathwayBrowser/#/R-DDI-9014433 RHOG GEFs activate RHOG IEA Dictyostelium discoideum DDB_G0278011 R-DDI-9014449 https://reactome.org/PathwayBrowser/#/R-DDI-9014449 RHOG binds effectors at the plasma membrane IEA Dictyostelium discoideum DDB_G0278011 R-DDI-9014454 https://reactome.org/PathwayBrowser/#/R-DDI-9014454 RHOG translocates to the ER membrane IEA Dictyostelium discoideum DDB_G0278011 R-DDI-9014456 https://reactome.org/PathwayBrowser/#/R-DDI-9014456 GDIs block activation of RHOG IEA Dictyostelium discoideum DDB_G0278011 R-DDI-9018754 https://reactome.org/PathwayBrowser/#/R-DDI-9018754 GDIs bind RHOH IEA Dictyostelium discoideum DDB_G0278011 R-DDI-9018756 https://reactome.org/PathwayBrowser/#/R-DDI-9018756 RHOH binds GTP IEA Dictyostelium discoideum DDB_G0278011 R-DDI-9018758 https://reactome.org/PathwayBrowser/#/R-DDI-9018758 RHOH binds effectors at the plasma membrane IEA Dictyostelium discoideum DDB_G0278011 R-DDI-9018774 https://reactome.org/PathwayBrowser/#/R-DDI-9018774 RHOBTB1 binds GTP IEA Dictyostelium discoideum DDB_G0278011 R-DDI-9018778 https://reactome.org/PathwayBrowser/#/R-DDI-9018778 RHOBTB1 binds interacting proteins at the endosome membrane IEA Dictyostelium discoideum DDB_G0278011 R-DDI-9018787 https://reactome.org/PathwayBrowser/#/R-DDI-9018787 RHOBTB2 binds interacting proteins at the endosome membrane IEA Dictyostelium discoideum DDB_G0278011 R-DDI-9714477 https://reactome.org/PathwayBrowser/#/R-DDI-9714477 RAC2 binds effectors at the mitochondrial outer membrane IEA Dictyostelium discoideum DDB_G0278011 R-DDI-9714480 https://reactome.org/PathwayBrowser/#/R-DDI-9714480 RAC2 translocates to the mitochondrial membrane IEA Dictyostelium discoideum DDB_G0278011 R-DDI-9714483 https://reactome.org/PathwayBrowser/#/R-DDI-9714483 RAC2 translocates to the ER membrane IEA Dictyostelium discoideum DDB_G0278027 R-DDI-9770236 https://reactome.org/PathwayBrowser/#/R-DDI-9770236 Formation of the Spliceosomal P complex and exon ligation IEA Dictyostelium discoideum DDB_G0278031 R-DDI-2454264 https://reactome.org/PathwayBrowser/#/R-DDI-2454264 11cROL binds to RLBP1 to form RLBP1:11cROL IEA Dictyostelium discoideum DDB_G0278031 R-DDI-2465919 https://reactome.org/PathwayBrowser/#/R-DDI-2465919 AWAT2 transfers PALM to 11cROL forming 11cRPALM IEA Dictyostelium discoideum DDB_G0278031 R-DDI-2465971 https://reactome.org/PathwayBrowser/#/R-DDI-2465971 RLBP1 binds atROL to form RLBP1:atROL IEA Dictyostelium discoideum DDB_G0278031 R-DDI-5333658 https://reactome.org/PathwayBrowser/#/R-DDI-5333658 CLAT:AP1:CLVS bind PI(3,5)P2 IEA Dictyostelium discoideum DDB_G0278031 R-DDI-8874705 https://reactome.org/PathwayBrowser/#/R-DDI-8874705 TTPA transports alpha-TOH from lysosomal membrane to plasma membrane IEA Dictyostelium discoideum DDB_G0278031 R-DDI-8874718 https://reactome.org/PathwayBrowser/#/R-DDI-8874718 TTPA binds alpha-TOH IEA Dictyostelium discoideum DDB_G0278031 R-DDI-8960973 https://reactome.org/PathwayBrowser/#/R-DDI-8960973 RLBP1:11cRAL dissociates IEA Dictyostelium discoideum DDB_G0278039 R-DDI-109638 https://reactome.org/PathwayBrowser/#/R-DDI-109638 Recruitment of RNA Polymerase II Holoenzyme by TFIIF to the pol II promoter:TFIID:TFIIA:TFIIB complex IEA Dictyostelium discoideum DDB_G0278039 R-DDI-109639 https://reactome.org/PathwayBrowser/#/R-DDI-109639 Formation of the closed pre-initiation complex IEA Dictyostelium discoideum DDB_G0278039 R-DDI-111264 https://reactome.org/PathwayBrowser/#/R-DDI-111264 Addition of nucleotides between position +11 and +30 IEA Dictyostelium discoideum DDB_G0278039 R-DDI-112383 https://reactome.org/PathwayBrowser/#/R-DDI-112383 Hypophosphorylation of RNA Pol II CTD by FCP1P protein IEA Dictyostelium discoideum DDB_G0278039 R-DDI-113407 https://reactome.org/PathwayBrowser/#/R-DDI-113407 DSIF complex binds to RNA Pol II (hypophosphorylated) IEA Dictyostelium discoideum DDB_G0278039 R-DDI-113409 https://reactome.org/PathwayBrowser/#/R-DDI-113409 Abortive termination of early transcription elongation by DSIF:NELF IEA Dictyostelium discoideum DDB_G0278039 R-DDI-113430 https://reactome.org/PathwayBrowser/#/R-DDI-113430 Extrusion of 5'-end of 30 nt long transcript through the pore in Pol II complex IEA Dictyostelium discoideum DDB_G0278039 R-DDI-6781818 https://reactome.org/PathwayBrowser/#/R-DDI-6781818 RNA Pol II initiates transcription from damaged DNA template IEA Dictyostelium discoideum DDB_G0278039 R-DDI-6781824 https://reactome.org/PathwayBrowser/#/R-DDI-6781824 Active RNA Pol II complex transcribes lesion-containing DNA template IEA Dictyostelium discoideum DDB_G0278039 R-DDI-6781833 https://reactome.org/PathwayBrowser/#/R-DDI-6781833 ERCC8 (CSA) binds stalled RNA Pol II IEA Dictyostelium discoideum DDB_G0278039 R-DDI-6781840 https://reactome.org/PathwayBrowser/#/R-DDI-6781840 ERCC6 binds stalled RNA Pol II IEA Dictyostelium discoideum DDB_G0278039 R-DDI-6781867 https://reactome.org/PathwayBrowser/#/R-DDI-6781867 ERCC8:DDB1:CUL4:RBX1 ubiquitinates ERCC6 and RNA Pol II IEA Dictyostelium discoideum DDB_G0278039 R-DDI-6782069 https://reactome.org/PathwayBrowser/#/R-DDI-6782069 UVSSA:USP7 deubiquitinates ERCC6 IEA Dictyostelium discoideum DDB_G0278039 R-DDI-6782131 https://reactome.org/PathwayBrowser/#/R-DDI-6782131 ERCC2-facilitated RNA Pol II backtracking in TC-NER IEA Dictyostelium discoideum DDB_G0278039 R-DDI-6782141 https://reactome.org/PathwayBrowser/#/R-DDI-6782141 Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in TC-NER IEA Dictyostelium discoideum DDB_G0278039 R-DDI-6782204 https://reactome.org/PathwayBrowser/#/R-DDI-6782204 5' incision of damaged DNA strand by ERCC1:ERCC4 in TC-NER IEA Dictyostelium discoideum DDB_G0278039 R-DDI-6782208 https://reactome.org/PathwayBrowser/#/R-DDI-6782208 Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in TC-NER IEA Dictyostelium discoideum DDB_G0278039 R-DDI-6782211 https://reactome.org/PathwayBrowser/#/R-DDI-6782211 DNA polymerases delta, epsilon or kappa bind the TC-NER site IEA Dictyostelium discoideum DDB_G0278039 R-DDI-6782227 https://reactome.org/PathwayBrowser/#/R-DDI-6782227 Ligation of newly synthesized repair patch to incised DNA in TC-NER IEA Dictyostelium discoideum DDB_G0278039 R-DDI-6797606 https://reactome.org/PathwayBrowser/#/R-DDI-6797606 CDK12 phosphorylates RNA Pol II CTD at DNA repair genes IEA Dictyostelium discoideum DDB_G0278039 R-DDI-6797616 https://reactome.org/PathwayBrowser/#/R-DDI-6797616 CCNK:CDK12 binds RNA Pol II at DNA repair genes IEA Dictyostelium discoideum DDB_G0278039 R-DDI-6810233 https://reactome.org/PathwayBrowser/#/R-DDI-6810233 CDK7 phosphorylates serine-5 and serine-7 of heptad repeats in C-terminal domain of RNA polymerase II at snRNA promoter IEA Dictyostelium discoideum DDB_G0278039 R-DDI-6810238 https://reactome.org/PathwayBrowser/#/R-DDI-6810238 RNA polymerase II binds initiation factors at promoter of snRNA gene (U1, U2, U4, U4atac, U5, U11, U12) IEA Dictyostelium discoideum DDB_G0278039 R-DDI-6814555 https://reactome.org/PathwayBrowser/#/R-DDI-6814555 Integrator complex processes the 3' end of snRNA IEA Dictyostelium discoideum DDB_G0278039 R-DDI-6814559 https://reactome.org/PathwayBrowser/#/R-DDI-6814559 Pre-snRNA is elongated and capped with 7-methylguanosine IEA Dictyostelium discoideum DDB_G0278039 R-DDI-72103 https://reactome.org/PathwayBrowser/#/R-DDI-72103 Formation of pre-mRNPs IEA Dictyostelium discoideum DDB_G0278039 R-DDI-73757 https://reactome.org/PathwayBrowser/#/R-DDI-73757 Binding of RRN3 to RNA Polymerase I IEA Dictyostelium discoideum DDB_G0278039 R-DDI-73769 https://reactome.org/PathwayBrowser/#/R-DDI-73769 Loss of Rrn3 from RNA Polymerase I promoter escape complex IEA Dictyostelium discoideum DDB_G0278039 R-DDI-73946 https://reactome.org/PathwayBrowser/#/R-DDI-73946 Abortive initiation after formation of the first phosphodiester bond IEA Dictyostelium discoideum DDB_G0278039 R-DDI-74986 https://reactome.org/PathwayBrowser/#/R-DDI-74986 Elongation of pre-rRNA transcript IEA Dictyostelium discoideum DDB_G0278039 R-DDI-75095 https://reactome.org/PathwayBrowser/#/R-DDI-75095 Binding of TFIIE to the growing preinitiation complex IEA Dictyostelium discoideum DDB_G0278039 R-DDI-75850 https://reactome.org/PathwayBrowser/#/R-DDI-75850 Addition of the third nucleotide on the nascent transcript IEA Dictyostelium discoideum DDB_G0278039 R-DDI-75856 https://reactome.org/PathwayBrowser/#/R-DDI-75856 Abortive Initiation Before Second Transition IEA Dictyostelium discoideum DDB_G0278039 R-DDI-75861 https://reactome.org/PathwayBrowser/#/R-DDI-75861 NTP Binds Active Site of RNA Polymerase II IEA Dictyostelium discoideum DDB_G0278039 R-DDI-75862 https://reactome.org/PathwayBrowser/#/R-DDI-75862 Fall Back to Closed Pre-initiation Complex IEA Dictyostelium discoideum DDB_G0278039 R-DDI-75864 https://reactome.org/PathwayBrowser/#/R-DDI-75864 Newly Formed Phosphodiester Bond Stabilized and PPi Released IEA Dictyostelium discoideum DDB_G0278039 R-DDI-75866 https://reactome.org/PathwayBrowser/#/R-DDI-75866 Nucleophillic Attack by 3'-hydroxyl Oxygen of nascent transcript on the Alpha Phosphate of NTP IEA Dictyostelium discoideum DDB_G0278039 R-DDI-75869 https://reactome.org/PathwayBrowser/#/R-DDI-75869 Addition of the fourth nucleotide on the Nascent Transcript: Second Transition IEA Dictyostelium discoideum DDB_G0278039 R-DDI-75873 https://reactome.org/PathwayBrowser/#/R-DDI-75873 Addition of Nucleotides 5 through 9 on the growing Transcript IEA Dictyostelium discoideum DDB_G0278039 R-DDI-75891 https://reactome.org/PathwayBrowser/#/R-DDI-75891 Abortive Initiation After Second Transition IEA Dictyostelium discoideum DDB_G0278039 R-DDI-75949 https://reactome.org/PathwayBrowser/#/R-DDI-75949 RNA Polymerase II Promoter Opening: First Transition IEA Dictyostelium discoideum DDB_G0278039 R-DDI-76056 https://reactome.org/PathwayBrowser/#/R-DDI-76056 Recruitment of RNA polymerase III to TFIIIB:TFIIIC:TFIIIA:Type 1 Promoter Complex IEA Dictyostelium discoideum DDB_G0278039 R-DDI-76576 https://reactome.org/PathwayBrowser/#/R-DDI-76576 Addition of nucleotides 10 and 11 on the growing transcript: Third Transition IEA Dictyostelium discoideum DDB_G0278039 R-DDI-77068 https://reactome.org/PathwayBrowser/#/R-DDI-77068 Activation of GT IEA Dictyostelium discoideum DDB_G0278039 R-DDI-77069 https://reactome.org/PathwayBrowser/#/R-DDI-77069 RNA Polymerase II CTD (phosphorylated) binds to CE IEA Dictyostelium discoideum DDB_G0278039 R-DDI-77071 https://reactome.org/PathwayBrowser/#/R-DDI-77071 Phosphorylation (Ser5) of RNA pol II CTD IEA Dictyostelium discoideum DDB_G0278039 R-DDI-77073 https://reactome.org/PathwayBrowser/#/R-DDI-77073 SPT5 subunit of Pol II binds the RNA triphosphatase (RTP) IEA Dictyostelium discoideum DDB_G0278039 R-DDI-77077 https://reactome.org/PathwayBrowser/#/R-DDI-77077 Capping complex formation IEA Dictyostelium discoideum DDB_G0278039 R-DDI-77078 https://reactome.org/PathwayBrowser/#/R-DDI-77078 Hydrolysis of the 5'-end of the nascent transcript by the capping enzyme IEA Dictyostelium discoideum DDB_G0278039 R-DDI-77081 https://reactome.org/PathwayBrowser/#/R-DDI-77081 Formation of the CE:GMP intermediate complex IEA Dictyostelium discoideum DDB_G0278039 R-DDI-77083 https://reactome.org/PathwayBrowser/#/R-DDI-77083 Transfer of GMP from the capping enzyme GT site to 5'-end of mRNA IEA Dictyostelium discoideum DDB_G0278039 R-DDI-77085 https://reactome.org/PathwayBrowser/#/R-DDI-77085 Dissociation of transcript with 5'-GMP from GT IEA Dictyostelium discoideum DDB_G0278039 R-DDI-77090 https://reactome.org/PathwayBrowser/#/R-DDI-77090 Methylation of GMP-cap by RNA Methyltransferase IEA Dictyostelium discoideum DDB_G0278039 R-DDI-77095 https://reactome.org/PathwayBrowser/#/R-DDI-77095 Recognition and binding of the mRNA cap by the cap-binding complex IEA Dictyostelium discoideum DDB_G0278039 R-DDI-83805 https://reactome.org/PathwayBrowser/#/R-DDI-83805 Recruitment of RNA Polymerase III to the TFIIIB:TFIIIC: Type 2 Promoter Complex IEA Dictyostelium discoideum DDB_G0278039 R-DDI-9012319 https://reactome.org/PathwayBrowser/#/R-DDI-9012319 p-TEFb phosphorylates serine 2 in RNA polymerase II CTD IEA Dictyostelium discoideum DDB_G0278039 R-DDI-9613494 https://reactome.org/PathwayBrowser/#/R-DDI-9613494 Unwinding of DNA for the Nascent Transcript: Second Transition IEA Dictyostelium discoideum DDB_G0278039 R-DDI-9613497 https://reactome.org/PathwayBrowser/#/R-DDI-9613497 Unwinding DNA for the nascent transcript IEA Dictyostelium discoideum DDB_G0278039 R-DDI-9684118 https://reactome.org/PathwayBrowser/#/R-DDI-9684118 ERCC3-facilitated RNA Pol II backtracking in TC-NER IEA Dictyostelium discoideum DDB_G0278039 R-DDI-9770236 https://reactome.org/PathwayBrowser/#/R-DDI-9770236 Formation of the Spliceosomal P complex and exon ligation IEA Dictyostelium discoideum DDB_G0278049 R-DDI-983140 https://reactome.org/PathwayBrowser/#/R-DDI-983140 Transfer of Ub from E2 to substrate and release of E2 IEA Dictyostelium discoideum DDB_G0278049 R-DDI-983147 https://reactome.org/PathwayBrowser/#/R-DDI-983147 Release of E3 from polyubiquitinated substrate IEA Dictyostelium discoideum DDB_G0278049 R-DDI-983156 https://reactome.org/PathwayBrowser/#/R-DDI-983156 Polyubiquitination of substrate IEA Dictyostelium discoideum DDB_G0278049 R-DDI-983157 https://reactome.org/PathwayBrowser/#/R-DDI-983157 Interaction of E3 with substrate and E2-Ub complex IEA Dictyostelium discoideum DDB_G0278059 R-DDI-727759 https://reactome.org/PathwayBrowser/#/R-DDI-727759 SLC33A1 transports Ac-CoA from cytosol to Golgi lumen IEA Dictyostelium discoideum DDB_G0278061 R-DDI-6809011 https://reactome.org/PathwayBrowser/#/R-DDI-6809011 cis-Golgi t-SNAREs bind YKT6 on tethered vesicle IEA Dictyostelium discoideum DDB_G0278063 R-DDI-9837978 https://reactome.org/PathwayBrowser/#/R-DDI-9837978 LONP1 binds mitochondrial inner membrane proteins IEA Dictyostelium discoideum DDB_G0278063 R-DDI-9838004 https://reactome.org/PathwayBrowser/#/R-DDI-9838004 LONP1 degrades mitochondrial inner membrane proteins IEA Dictyostelium discoideum DDB_G0278063 R-DDI-9838081 https://reactome.org/PathwayBrowser/#/R-DDI-9838081 LONP1 degrades mitochondrial matrix proteins IEA Dictyostelium discoideum DDB_G0278063 R-DDI-9838093 https://reactome.org/PathwayBrowser/#/R-DDI-9838093 LONP1 binds mitochondrial matrix proteins IEA Dictyostelium discoideum DDB_G0278075 R-DDI-1169398 https://reactome.org/PathwayBrowser/#/R-DDI-1169398 ISGylation of host protein filamin B IEA Dictyostelium discoideum DDB_G0278075 R-DDI-1169402 https://reactome.org/PathwayBrowser/#/R-DDI-1169402 ISGylation of E2 conjugating enzymes IEA Dictyostelium discoideum DDB_G0278075 R-DDI-1169403 https://reactome.org/PathwayBrowser/#/R-DDI-1169403 Interaction of E3 ligase with ISG15:E2 complex IEA Dictyostelium discoideum DDB_G0278075 R-DDI-1169404 https://reactome.org/PathwayBrowser/#/R-DDI-1169404 Transfer of ISG15 from E1 to E2 (UBCH8) IEA Dictyostelium discoideum DDB_G0278075 R-DDI-1169406 https://reactome.org/PathwayBrowser/#/R-DDI-1169406 ISGylation of host proteins IEA Dictyostelium discoideum DDB_G0278075 R-DDI-1678842 https://reactome.org/PathwayBrowser/#/R-DDI-1678842 Competitive inhibition of translation initiation by ISGylated 4EHP IEA Dictyostelium discoideum DDB_G0278075 R-DDI-1678843 https://reactome.org/PathwayBrowser/#/R-DDI-1678843 ISGylation of protein translation regulator 4EHP IEA Dictyostelium discoideum DDB_G0278075 R-DDI-8852127 https://reactome.org/PathwayBrowser/#/R-DDI-8852127 UBA6 conjugates ubiquitin to cytosolic E2 enzymes IEA Dictyostelium discoideum DDB_G0278075 R-DDI-8852129 https://reactome.org/PathwayBrowser/#/R-DDI-8852129 UBA1 conjugates ubiquitin to cytosolic E2 enzymes IEA Dictyostelium discoideum DDB_G0278075 R-DDI-8852130 https://reactome.org/PathwayBrowser/#/R-DDI-8852130 UBA1 conjugates ubiquitin to nuclear E2 enzymes IEA Dictyostelium discoideum DDB_G0278075 R-DDI-8938770 https://reactome.org/PathwayBrowser/#/R-DDI-8938770 RNF144A binds PRKDC and Ubiquitin:UBE2L3 IEA Dictyostelium discoideum DDB_G0278075 R-DDI-8938773 https://reactome.org/PathwayBrowser/#/R-DDI-8938773 RNF144A polyubiquitinates PRKDC IEA Dictyostelium discoideum DDB_G0278075 R-DDI-936563 https://reactome.org/PathwayBrowser/#/R-DDI-936563 ISGylation of DDX58 IEA Dictyostelium discoideum DDB_G0278075 R-DDI-9793472 https://reactome.org/PathwayBrowser/#/R-DDI-9793472 RIPK3 binds p-S9-PRKN IEA Dictyostelium discoideum DDB_G0278075 R-DDI-9793485 https://reactome.org/PathwayBrowser/#/R-DDI-9793485 PRKN polyubiquitinates RIPK3 IEA Dictyostelium discoideum DDB_G0278075 R-DDI-983140 https://reactome.org/PathwayBrowser/#/R-DDI-983140 Transfer of Ub from E2 to substrate and release of E2 IEA Dictyostelium discoideum DDB_G0278075 R-DDI-983152 https://reactome.org/PathwayBrowser/#/R-DDI-983152 Transfer of ubiquitin from E1 to E2 IEA Dictyostelium discoideum DDB_G0278075 R-DDI-983156 https://reactome.org/PathwayBrowser/#/R-DDI-983156 Polyubiquitination of substrate IEA Dictyostelium discoideum DDB_G0278075 R-DDI-983157 https://reactome.org/PathwayBrowser/#/R-DDI-983157 Interaction of E3 with substrate and E2-Ub complex IEA Dictyostelium discoideum DDB_G0278095 R-DDI-8952873 https://reactome.org/PathwayBrowser/#/R-DDI-8952873 MECR dimer reduces tdec2-CoA to DEC-CoA IEA Dictyostelium discoideum DDB_G0278105 R-DDI-72103 https://reactome.org/PathwayBrowser/#/R-DDI-72103 Formation of pre-mRNPs IEA Dictyostelium discoideum DDB_G0278105 R-DDI-9770236 https://reactome.org/PathwayBrowser/#/R-DDI-9770236 Formation of the Spliceosomal P complex and exon ligation IEA Dictyostelium discoideum DDB_G0278107 R-DDI-965019 https://reactome.org/PathwayBrowser/#/R-DDI-965019 2xPNPO:2xFMN oxidizes PDXP to PXLP IEA Dictyostelium discoideum DDB_G0278107 R-DDI-965079 https://reactome.org/PathwayBrowser/#/R-DDI-965079 2xPNPO:2xFMN oxidizes PXAP to PXLP IEA Dictyostelium discoideum DDB_G0278113 R-DDI-5676637 https://reactome.org/PathwayBrowser/#/R-DDI-5676637 PTPLs dehydrate VLC3HA-CoA to VLCTDA-CoA IEA Dictyostelium discoideum DDB_G0278117 R-DDI-9609921 https://reactome.org/PathwayBrowser/#/R-DDI-9609921 SGTA binds Tail-anchored protein IEA Dictyostelium discoideum DDB_G0278155 R-DDI-176054 https://reactome.org/PathwayBrowser/#/R-DDI-176054 GST dimers conjugate GSH with cytosolic substrates IEA Dictyostelium discoideum DDB_G0278155 R-DDI-71173 https://reactome.org/PathwayBrowser/#/R-DDI-71173 GSTZ1 isomerizes 4-MAA IEA Dictyostelium discoideum DDB_G0278155 R-DDI-9011595 https://reactome.org/PathwayBrowser/#/R-DDI-9011595 GSTZ1 dimer dehalogenates DCA IEA Dictyostelium discoideum DDB_G0278157 R-DDI-70994 https://reactome.org/PathwayBrowser/#/R-DDI-70994 SDH complex dehydrogenates succinate IEA Dictyostelium discoideum DDB_G0278159 R-DDI-1483089 https://reactome.org/PathwayBrowser/#/R-DDI-1483089 PE is converted to PS by PTDSS2 IEA Dictyostelium discoideum DDB_G0278159 R-DDI-1483186 https://reactome.org/PathwayBrowser/#/R-DDI-1483186 PC is converted to PS by PTDSS1 IEA Dictyostelium discoideum DDB_G0278161 R-DDI-434650 https://reactome.org/PathwayBrowser/#/R-DDI-434650 MATEs mediate extrusion of xenobiotics IEA Dictyostelium discoideum DDB_G0278179 R-DDI-5251955 https://reactome.org/PathwayBrowser/#/R-DDI-5251955 HSP40s activate intrinsic ATPase activity of HSP70s in the nucleoplasm IEA Dictyostelium discoideum DDB_G0278179 R-DDI-5251959 https://reactome.org/PathwayBrowser/#/R-DDI-5251959 HSP40s activate intrinsic ATPase activity of HSP70s in the cytosol IEA Dictyostelium discoideum DDB_G0278189 R-DDI-6814555 https://reactome.org/PathwayBrowser/#/R-DDI-6814555 Integrator complex processes the 3' end of snRNA IEA Dictyostelium discoideum DDB_G0278189 R-DDI-6814559 https://reactome.org/PathwayBrowser/#/R-DDI-6814559 Pre-snRNA is elongated and capped with 7-methylguanosine IEA Dictyostelium discoideum DDB_G0278203 R-DDI-5687360 https://reactome.org/PathwayBrowser/#/R-DDI-5687360 POLL or POLM extends aligned DNA DSB ends to fill gaps IEA Dictyostelium discoideum DDB_G0278205 R-DDI-156823 https://reactome.org/PathwayBrowser/#/R-DDI-156823 Association of phospho-L13a with GAIT element of Ceruloplasmin mRNA IEA Dictyostelium discoideum DDB_G0278205 R-DDI-72621 https://reactome.org/PathwayBrowser/#/R-DDI-72621 Ribosomal scanning IEA Dictyostelium discoideum DDB_G0278205 R-DDI-72673 https://reactome.org/PathwayBrowser/#/R-DDI-72673 Release of 40S and 60S subunits from the 80S ribosome IEA Dictyostelium discoideum DDB_G0278205 R-DDI-72676 https://reactome.org/PathwayBrowser/#/R-DDI-72676 eIF3 and eIF1A bind to the 40S subunit IEA Dictyostelium discoideum DDB_G0278205 R-DDI-72691 https://reactome.org/PathwayBrowser/#/R-DDI-72691 Formation of the 43S pre-initiation complex IEA Dictyostelium discoideum DDB_G0278205 R-DDI-72697 https://reactome.org/PathwayBrowser/#/R-DDI-72697 Start codon recognition IEA Dictyostelium discoideum DDB_G0278241 R-DDI-6782069 https://reactome.org/PathwayBrowser/#/R-DDI-6782069 UVSSA:USP7 deubiquitinates ERCC6 IEA Dictyostelium discoideum DDB_G0278241 R-DDI-6782131 https://reactome.org/PathwayBrowser/#/R-DDI-6782131 ERCC2-facilitated RNA Pol II backtracking in TC-NER IEA Dictyostelium discoideum DDB_G0278241 R-DDI-6782141 https://reactome.org/PathwayBrowser/#/R-DDI-6782141 Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in TC-NER IEA Dictyostelium discoideum DDB_G0278241 R-DDI-6782204 https://reactome.org/PathwayBrowser/#/R-DDI-6782204 5' incision of damaged DNA strand by ERCC1:ERCC4 in TC-NER IEA Dictyostelium discoideum DDB_G0278241 R-DDI-6782208 https://reactome.org/PathwayBrowser/#/R-DDI-6782208 Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in TC-NER IEA Dictyostelium discoideum DDB_G0278241 R-DDI-6782211 https://reactome.org/PathwayBrowser/#/R-DDI-6782211 DNA polymerases delta, epsilon or kappa bind the TC-NER site IEA Dictyostelium discoideum DDB_G0278241 R-DDI-6782227 https://reactome.org/PathwayBrowser/#/R-DDI-6782227 Ligation of newly synthesized repair patch to incised DNA in TC-NER IEA Dictyostelium discoideum DDB_G0278241 R-DDI-6797606 https://reactome.org/PathwayBrowser/#/R-DDI-6797606 CDK12 phosphorylates RNA Pol II CTD at DNA repair genes IEA Dictyostelium discoideum DDB_G0278241 R-DDI-6797616 https://reactome.org/PathwayBrowser/#/R-DDI-6797616 CCNK:CDK12 binds RNA Pol II at DNA repair genes IEA Dictyostelium discoideum DDB_G0278241 R-DDI-9684118 https://reactome.org/PathwayBrowser/#/R-DDI-9684118 ERCC3-facilitated RNA Pol II backtracking in TC-NER IEA Dictyostelium discoideum DDB_G0278259 R-DDI-6799581 https://reactome.org/PathwayBrowser/#/R-DDI-6799581 MAN2B2 hydrolyses GlcNAc (Man)3 to GlcNAc:Man IEA Dictyostelium discoideum DDB_G0278261 R-DDI-429101 https://reactome.org/PathwayBrowser/#/R-DDI-429101 HMIT co-transports myo-inositol with a proton IEA Dictyostelium discoideum DDB_G0278263 R-DDI-73757 https://reactome.org/PathwayBrowser/#/R-DDI-73757 Binding of RRN3 to RNA Polymerase I IEA Dictyostelium discoideum DDB_G0278263 R-DDI-73769 https://reactome.org/PathwayBrowser/#/R-DDI-73769 Loss of Rrn3 from RNA Polymerase I promoter escape complex IEA Dictyostelium discoideum DDB_G0278263 R-DDI-74986 https://reactome.org/PathwayBrowser/#/R-DDI-74986 Elongation of pre-rRNA transcript IEA Dictyostelium discoideum DDB_G0278275 R-DDI-199803 https://reactome.org/PathwayBrowser/#/R-DDI-199803 xylulose 5-phosphate <=> D-ribulose 5-phosphate IEA Dictyostelium discoideum DDB_G0278275 R-DDI-71303 https://reactome.org/PathwayBrowser/#/R-DDI-71303 RPE dimers isomerise RU5P to XY5P IEA Dictyostelium discoideum DDB_G0278285 R-DDI-6807872 https://reactome.org/PathwayBrowser/#/R-DDI-6807872 Active ARF recruits coatomer IEA Dictyostelium discoideum DDB_G0278285 R-DDI-6807875 https://reactome.org/PathwayBrowser/#/R-DDI-6807875 ARFGAP, cargo, v-SNAREs and p24 proteins bind nascent COPI complex IEA Dictyostelium discoideum DDB_G0278285 R-DDI-6807877 https://reactome.org/PathwayBrowser/#/R-DDI-6807877 ARFGAPs stimulate ARF GTPase activity IEA Dictyostelium discoideum DDB_G0278285 R-DDI-6809003 https://reactome.org/PathwayBrowser/#/R-DDI-6809003 ERGIC-to-Golgi vesicles bind dynein:dynactin IEA Dictyostelium discoideum DDB_G0278285 R-DDI-6809011 https://reactome.org/PathwayBrowser/#/R-DDI-6809011 cis-Golgi t-SNAREs bind YKT6 on tethered vesicle IEA Dictyostelium discoideum DDB_G0278285 R-DDI-6811412 https://reactome.org/PathwayBrowser/#/R-DDI-6811412 Active ARF recruits coatomer to the Golgi IEA Dictyostelium discoideum DDB_G0278285 R-DDI-6811417 https://reactome.org/PathwayBrowser/#/R-DDI-6811417 ARFGAP, cargo, vSNARES and p24 proteins bind COPI vesicles at Golgi IEA Dictyostelium discoideum DDB_G0278285 R-DDI-6811418 https://reactome.org/PathwayBrowser/#/R-DDI-6811418 ARFGAPs stimulate ARF GTPase activity at the Golgi membrane IEA Dictyostelium discoideum DDB_G0278285 R-DDI-6811427 https://reactome.org/PathwayBrowser/#/R-DDI-6811427 COPI vesicle uncoating at the ER IEA Dictyostelium discoideum DDB_G0278293 R-DDI-9825759 https://reactome.org/PathwayBrowser/#/R-DDI-9825759 MAPK-dependent phosphorylation of KARS IEA Dictyostelium discoideum DDB_G0278295 R-DDI-6798751 https://reactome.org/PathwayBrowser/#/R-DDI-6798751 Exocytosis of azurophil granule lumen proteins IEA Dictyostelium discoideum DDB_G0278295 R-DDI-8876472 https://reactome.org/PathwayBrowser/#/R-DDI-8876472 NPC2 binds CHOL IEA Dictyostelium discoideum DDB_G0278295 R-DDI-8876484 https://reactome.org/PathwayBrowser/#/R-DDI-8876484 NPC2 transfers CHOL to NPC1 IEA Dictyostelium discoideum DDB_G0278311 R-DDI-1675795 https://reactome.org/PathwayBrowser/#/R-DDI-1675795 PI3P is dephosphorylated to PI by MTM proteins at the late endosome membrane IEA Dictyostelium discoideum DDB_G0278311 R-DDI-1675994 https://reactome.org/PathwayBrowser/#/R-DDI-1675994 PI3P is dephosphorylated to PI by SYNJ/MTMs at the plasma membrane IEA Dictyostelium discoideum DDB_G0278311 R-DDI-1676065 https://reactome.org/PathwayBrowser/#/R-DDI-1676065 PI(3,5)P2 is dephosphorylated to PI5P by MTM proteins at the late endosome membrane IEA Dictyostelium discoideum DDB_G0278311 R-DDI-1676105 https://reactome.org/PathwayBrowser/#/R-DDI-1676105 PI(3,5)P2 is dephosphorylated to PI5P by MTM proteins at the early endosome membrane IEA Dictyostelium discoideum DDB_G0278311 R-DDI-1676141 https://reactome.org/PathwayBrowser/#/R-DDI-1676141 PI3P is dephosphorylated to PI by MTM proteins at the early endosome membrane IEA Dictyostelium discoideum DDB_G0278311 R-DDI-1676203 https://reactome.org/PathwayBrowser/#/R-DDI-1676203 PI(3,5)P2 is dephosphorylated to PI5P by SYNJ/MTMs at the plasma membrane IEA Dictyostelium discoideum DDB_G0278311 R-DDI-5679206 https://reactome.org/PathwayBrowser/#/R-DDI-5679206 MTMR14, MTMR3 dephosphorylate PI3P IEA Dictyostelium discoideum DDB_G0278311 R-DDI-6809254 https://reactome.org/PathwayBrowser/#/R-DDI-6809254 MTMR8 binds MTMR9 IEA Dictyostelium discoideum DDB_G0278311 R-DDI-6809309 https://reactome.org/PathwayBrowser/#/R-DDI-6809309 MTMR6 binds MTMR9 IEA Dictyostelium discoideum DDB_G0278311 R-DDI-6809320 https://reactome.org/PathwayBrowser/#/R-DDI-6809320 PI(3,5)P2 is dephosphorylated to PI5P by MTMR9-bound MTMR6 or MTMR8 at the plasma membrane IEA Dictyostelium discoideum DDB_G0278311 R-DDI-6809325 https://reactome.org/PathwayBrowser/#/R-DDI-6809325 PI3P is dephosphorylated to PI by MTMR9-bound MTMR8 or MTMR6 at the plasma membrane IEA Dictyostelium discoideum DDB_G0278311 R-DDI-6809680 https://reactome.org/PathwayBrowser/#/R-DDI-6809680 MTMR12 binds MTM1 IEA Dictyostelium discoideum DDB_G0278311 R-DDI-6809707 https://reactome.org/PathwayBrowser/#/R-DDI-6809707 MTMR12 binds MTMR2 IEA Dictyostelium discoideum DDB_G0278311 R-DDI-6809720 https://reactome.org/PathwayBrowser/#/R-DDI-6809720 PI3P is dephosphorylated to PI by MTM1:MTMR12 IEA Dictyostelium discoideum DDB_G0278311 R-DDI-6809764 https://reactome.org/PathwayBrowser/#/R-DDI-6809764 SBF1 binds MTMR2 IEA Dictyostelium discoideum DDB_G0278311 R-DDI-6809777 https://reactome.org/PathwayBrowser/#/R-DDI-6809777 PI3P is dephosphorylated to PI by MTMR2:SBF1 IEA Dictyostelium discoideum DDB_G0278311 R-DDI-6809778 https://reactome.org/PathwayBrowser/#/R-DDI-6809778 PI(3,5)P2 is dephosphorylated to PI5P by MTMR2:SBF1 IEA Dictyostelium discoideum DDB_G0278311 R-DDI-8876837 https://reactome.org/PathwayBrowser/#/R-DDI-8876837 RAB21 GEFs exchange GTP for GDP on RAB21 IEA Dictyostelium discoideum DDB_G0278321 R-DDI-76054 https://reactome.org/PathwayBrowser/#/R-DDI-76054 Binding of TFIIIC to TFIIIA:Type I Promoter complex IEA Dictyostelium discoideum DDB_G0278321 R-DDI-76056 https://reactome.org/PathwayBrowser/#/R-DDI-76056 Recruitment of RNA polymerase III to TFIIIB:TFIIIC:TFIIIA:Type 1 Promoter Complex IEA Dictyostelium discoideum DDB_G0278321 R-DDI-83723 https://reactome.org/PathwayBrowser/#/R-DDI-83723 Binding of TFIIIB to TFIIIC:TFIIIA:Type I Promoter complex IEA Dictyostelium discoideum DDB_G0278321 R-DDI-83788 https://reactome.org/PathwayBrowser/#/R-DDI-83788 Binding of TFIIIC to Type 2 promoter IEA Dictyostelium discoideum DDB_G0278321 R-DDI-83790 https://reactome.org/PathwayBrowser/#/R-DDI-83790 Binding of TFIIIB to TFIIC: Type 2 Promoter Complex IEA Dictyostelium discoideum DDB_G0278321 R-DDI-83805 https://reactome.org/PathwayBrowser/#/R-DDI-83805 Recruitment of RNA Polymerase III to the TFIIIB:TFIIIC: Type 2 Promoter Complex IEA Dictyostelium discoideum DDB_G0278345 R-DDI-6798751 https://reactome.org/PathwayBrowser/#/R-DDI-6798751 Exocytosis of azurophil granule lumen proteins IEA Dictyostelium discoideum DDB_G0278345 R-DDI-6800434 https://reactome.org/PathwayBrowser/#/R-DDI-6800434 Exocytosis of ficolin-rich granule lumen proteins IEA Dictyostelium discoideum DDB_G0278345 R-DDI-75848 https://reactome.org/PathwayBrowser/#/R-DDI-75848 ACLY tetramer transforms CIT to Ac-CoA IEA Dictyostelium discoideum DDB_G0278345 R-DDI-9734540 https://reactome.org/PathwayBrowser/#/R-DDI-9734540 ACLY tetramer binds ETC-1002-CoA IEA Dictyostelium discoideum DDB_G0278367 R-DDI-110364 https://reactome.org/PathwayBrowser/#/R-DDI-110364 PCNA:POLD,POLE:RPA:RFC and FEN1 bind APEX1 IEA Dictyostelium discoideum DDB_G0278367 R-DDI-110368 https://reactome.org/PathwayBrowser/#/R-DDI-110368 POLD,POLE-mediated DNA strand displacement synthesis IEA Dictyostelium discoideum DDB_G0278367 R-DDI-110371 https://reactome.org/PathwayBrowser/#/R-DDI-110371 LIG1 binds APEX1 and PCNA at SSB IEA Dictyostelium discoideum DDB_G0278367 R-DDI-5651805 https://reactome.org/PathwayBrowser/#/R-DDI-5651805 LIG1 bound to APEX1 and PCNA ligates SSB IEA Dictyostelium discoideum DDB_G0278367 R-DDI-5652005 https://reactome.org/PathwayBrowser/#/R-DDI-5652005 RAD18:UBE2B or RBX1:CUL4:DDB1:DTL ubiquitin ligase complex binds PCNA:POLD,POLE:RPA:RFC associated with damaged dsDNA IEA Dictyostelium discoideum DDB_G0278367 R-DDI-5652009 https://reactome.org/PathwayBrowser/#/R-DDI-5652009 RAD18:UBE2B or RBX1:CUL4:DDB1:DTL monoubiquitinates PCNA IEA Dictyostelium discoideum DDB_G0278367 R-DDI-5653838 https://reactome.org/PathwayBrowser/#/R-DDI-5653838 POLD,POLE binds deISGylated PCNA after TLS IEA Dictyostelium discoideum DDB_G0278367 R-DDI-5691001 https://reactome.org/PathwayBrowser/#/R-DDI-5691001 Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in GG-NER IEA Dictyostelium discoideum DDB_G0278367 R-DDI-6782208 https://reactome.org/PathwayBrowser/#/R-DDI-6782208 Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in TC-NER IEA Dictyostelium discoideum DDB_G0278367 R-DDI-6782211 https://reactome.org/PathwayBrowser/#/R-DDI-6782211 DNA polymerases delta, epsilon or kappa bind the TC-NER site IEA Dictyostelium discoideum DDB_G0278367 R-DDI-6782227 https://reactome.org/PathwayBrowser/#/R-DDI-6782227 Ligation of newly synthesized repair patch to incised DNA in TC-NER IEA Dictyostelium discoideum DDB_G0278367 R-DDI-68913 https://reactome.org/PathwayBrowser/#/R-DDI-68913 The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer at the origin IEA Dictyostelium discoideum DDB_G0278367 R-DDI-68914 https://reactome.org/PathwayBrowser/#/R-DDI-68914 DNA polymerase alpha:primase binds at the origin IEA Dictyostelium discoideum DDB_G0278367 R-DDI-68960 https://reactome.org/PathwayBrowser/#/R-DDI-68960 DNA polymerase epsilon binds at the origin IEA Dictyostelium discoideum DDB_G0278373 R-DDI-5358475 https://reactome.org/PathwayBrowser/#/R-DDI-5358475 DPH6 ligates ammonium to diphthine-EEF2 IEA Dictyostelium discoideum DDB_G0278401 R-DDI-1566981 https://reactome.org/PathwayBrowser/#/R-DDI-1566981 Fibronectin degradation by MMP1, 3, 7, 12, 13, 19, CTSS IEA Dictyostelium discoideum DDB_G0278401 R-DDI-2130706 https://reactome.org/PathwayBrowser/#/R-DDI-2130706 MHC class II antigen processing IEA Dictyostelium discoideum DDB_G0278401 R-DDI-6798745 https://reactome.org/PathwayBrowser/#/R-DDI-6798745 Exocytosis of tertiary granule lumen proteins IEA Dictyostelium discoideum DDB_G0278401 R-DDI-6800434 https://reactome.org/PathwayBrowser/#/R-DDI-6800434 Exocytosis of ficolin-rich granule lumen proteins IEA Dictyostelium discoideum DDB_G0278413 R-DDI-196840 https://reactome.org/PathwayBrowser/#/R-DDI-196840 3xPPCDC:3FMN decarboxylates PPC IEA Dictyostelium discoideum DDB_G0278427 R-DDI-8932413 https://reactome.org/PathwayBrowser/#/R-DDI-8932413 METTL10 transfers 3xCH3 from 3xAdoMet to EEF1A1 IEA Dictyostelium discoideum DDB_G0278429 R-DDI-156823 https://reactome.org/PathwayBrowser/#/R-DDI-156823 Association of phospho-L13a with GAIT element of Ceruloplasmin mRNA IEA Dictyostelium discoideum DDB_G0278429 R-DDI-1799332 https://reactome.org/PathwayBrowser/#/R-DDI-1799332 Nascent polypeptide:mRNA:ribosome complex binds signal recognition particle (SRP) IEA Dictyostelium discoideum DDB_G0278429 R-DDI-72621 https://reactome.org/PathwayBrowser/#/R-DDI-72621 Ribosomal scanning IEA Dictyostelium discoideum DDB_G0278429 R-DDI-72671 https://reactome.org/PathwayBrowser/#/R-DDI-72671 eIF5B:GTP is hydrolyzed and released IEA Dictyostelium discoideum DDB_G0278429 R-DDI-72672 https://reactome.org/PathwayBrowser/#/R-DDI-72672 The 60S subunit joins the translation initiation complex IEA Dictyostelium discoideum DDB_G0278429 R-DDI-72673 https://reactome.org/PathwayBrowser/#/R-DDI-72673 Release of 40S and 60S subunits from the 80S ribosome IEA Dictyostelium discoideum DDB_G0278429 R-DDI-72676 https://reactome.org/PathwayBrowser/#/R-DDI-72676 eIF3 and eIF1A bind to the 40S subunit IEA Dictyostelium discoideum DDB_G0278429 R-DDI-72691 https://reactome.org/PathwayBrowser/#/R-DDI-72691 Formation of the 43S pre-initiation complex IEA Dictyostelium discoideum DDB_G0278429 R-DDI-72697 https://reactome.org/PathwayBrowser/#/R-DDI-72697 Start codon recognition IEA Dictyostelium discoideum DDB_G0278429 R-DDI-927789 https://reactome.org/PathwayBrowser/#/R-DDI-927789 Formation of UPF1:eRF3 complex on mRNA with a premature termination codon and no Exon Junction Complex IEA Dictyostelium discoideum DDB_G0278429 R-DDI-927832 https://reactome.org/PathwayBrowser/#/R-DDI-927832 UPF1 binds an mRNP with a termination codon preceding an Exon Junction Complex IEA Dictyostelium discoideum DDB_G0278429 R-DDI-927889 https://reactome.org/PathwayBrowser/#/R-DDI-927889 SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex) IEA Dictyostelium discoideum DDB_G0278443 R-DDI-1675883 https://reactome.org/PathwayBrowser/#/R-DDI-1675883 PI is phosphorylated to PI4P by PI4KB at the Golgi membrane IEA Dictyostelium discoideum DDB_G0278443 R-DDI-1676152 https://reactome.org/PathwayBrowser/#/R-DDI-1676152 PI4KB binds to ARF1/3:GTP at the Golgi membrane IEA Dictyostelium discoideum DDB_G0278443 R-DDI-350769 https://reactome.org/PathwayBrowser/#/R-DDI-350769 trans-Golgi Network Coat Activation IEA Dictyostelium discoideum DDB_G0278443 R-DDI-5623508 https://reactome.org/PathwayBrowser/#/R-DDI-5623508 GBF1 stimulates nucleotide exchange on ARF4 IEA Dictyostelium discoideum DDB_G0278443 R-DDI-6807866 https://reactome.org/PathwayBrowser/#/R-DDI-6807866 GBF1 recruits ARF:GDP to the ERGIC IEA Dictyostelium discoideum DDB_G0278443 R-DDI-6807868 https://reactome.org/PathwayBrowser/#/R-DDI-6807868 GBF1 stimulates ARF nucleotide exchange IEA Dictyostelium discoideum DDB_G0278443 R-DDI-6807872 https://reactome.org/PathwayBrowser/#/R-DDI-6807872 Active ARF recruits coatomer IEA Dictyostelium discoideum DDB_G0278443 R-DDI-6807875 https://reactome.org/PathwayBrowser/#/R-DDI-6807875 ARFGAP, cargo, v-SNAREs and p24 proteins bind nascent COPI complex IEA Dictyostelium discoideum DDB_G0278443 R-DDI-6807877 https://reactome.org/PathwayBrowser/#/R-DDI-6807877 ARFGAPs stimulate ARF GTPase activity IEA Dictyostelium discoideum DDB_G0278443 R-DDI-6811411 https://reactome.org/PathwayBrowser/#/R-DDI-6811411 GBF1 recruits ARF:GDP to the Golgi IEA Dictyostelium discoideum DDB_G0278443 R-DDI-6811412 https://reactome.org/PathwayBrowser/#/R-DDI-6811412 Active ARF recruits coatomer to the Golgi IEA Dictyostelium discoideum DDB_G0278443 R-DDI-6811414 https://reactome.org/PathwayBrowser/#/R-DDI-6811414 GBF1 stimulates nucleotide exchange on ARF IEA Dictyostelium discoideum DDB_G0278443 R-DDI-6811417 https://reactome.org/PathwayBrowser/#/R-DDI-6811417 ARFGAP, cargo, vSNARES and p24 proteins bind COPI vesicles at Golgi IEA Dictyostelium discoideum DDB_G0278443 R-DDI-6811418 https://reactome.org/PathwayBrowser/#/R-DDI-6811418 ARFGAPs stimulate ARF GTPase activity at the Golgi membrane IEA Dictyostelium discoideum DDB_G0278443 R-DDI-8847880 https://reactome.org/PathwayBrowser/#/R-DDI-8847880 CYTH proteins bind ARF1:GTP IEA Dictyostelium discoideum DDB_G0278443 R-DDI-8847883 https://reactome.org/PathwayBrowser/#/R-DDI-8847883 CYTH proteins stimulate ARF1 GTPase activity IEA Dictyostelium discoideum DDB_G0278445 R-DDI-203797 https://reactome.org/PathwayBrowser/#/R-DDI-203797 ERKs are inactivated by dual-specific phosphatases (DUSPs) IEA Dictyostelium discoideum DDB_G0278445 R-DDI-5675373 https://reactome.org/PathwayBrowser/#/R-DDI-5675373 Nuclear DUSPs dephosphorylate MAPKs IEA Dictyostelium discoideum DDB_G0278445 R-DDI-5675376 https://reactome.org/PathwayBrowser/#/R-DDI-5675376 Cytosolic DUSPs dephosphorylate MAPKs IEA Dictyostelium discoideum DDB_G0278457 R-DDI-9018778 https://reactome.org/PathwayBrowser/#/R-DDI-9018778 RHOBTB1 binds interacting proteins at the endosome membrane IEA Dictyostelium discoideum DDB_G0278457 R-DDI-9018787 https://reactome.org/PathwayBrowser/#/R-DDI-9018787 RHOBTB2 binds interacting proteins at the endosome membrane IEA Dictyostelium discoideum DDB_G0278459 R-DDI-9854961 https://reactome.org/PathwayBrowser/#/R-DDI-9854961 SDHAF4 binds to FAD-SDHA IEA Dictyostelium discoideum DDB_G0278475 R-DDI-9639287 https://reactome.org/PathwayBrowser/#/R-DDI-9639287 SESN1,2 binds L-leucine and dissociates from GATOR2 IEA Dictyostelium discoideum DDB_G0278475 R-DDI-9640195 https://reactome.org/PathwayBrowser/#/R-DDI-9640195 RRAGA,B hydrolyzes GTP IEA Dictyostelium discoideum DDB_G0278479 R-DDI-77073 https://reactome.org/PathwayBrowser/#/R-DDI-77073 SPT5 subunit of Pol II binds the RNA triphosphatase (RTP) IEA Dictyostelium discoideum DDB_G0278479 R-DDI-77077 https://reactome.org/PathwayBrowser/#/R-DDI-77077 Capping complex formation IEA Dictyostelium discoideum DDB_G0278479 R-DDI-77078 https://reactome.org/PathwayBrowser/#/R-DDI-77078 Hydrolysis of the 5'-end of the nascent transcript by the capping enzyme IEA Dictyostelium discoideum DDB_G0278479 R-DDI-77081 https://reactome.org/PathwayBrowser/#/R-DDI-77081 Formation of the CE:GMP intermediate complex IEA Dictyostelium discoideum DDB_G0278479 R-DDI-77083 https://reactome.org/PathwayBrowser/#/R-DDI-77083 Transfer of GMP from the capping enzyme GT site to 5'-end of mRNA IEA Dictyostelium discoideum DDB_G0278479 R-DDI-77085 https://reactome.org/PathwayBrowser/#/R-DDI-77085 Dissociation of transcript with 5'-GMP from GT IEA Dictyostelium discoideum DDB_G0278479 R-DDI-77090 https://reactome.org/PathwayBrowser/#/R-DDI-77090 Methylation of GMP-cap by RNA Methyltransferase IEA Dictyostelium discoideum DDB_G0278483 R-DDI-5658424 https://reactome.org/PathwayBrowser/#/R-DDI-5658424 KBTBD7:CUL3:RBX1 ubiquitinates NF1 IEA Dictyostelium discoideum DDB_G0278483 R-DDI-5658430 https://reactome.org/PathwayBrowser/#/R-DDI-5658430 NF1 is degraded by the proteasome IEA Dictyostelium discoideum DDB_G0278483 R-DDI-5658438 https://reactome.org/PathwayBrowser/#/R-DDI-5658438 SPRED dimer binds NF1 IEA Dictyostelium discoideum DDB_G0278487 R-DDI-6797090 https://reactome.org/PathwayBrowser/#/R-DDI-6797090 CCNK binds CDK12 IEA Dictyostelium discoideum DDB_G0278487 R-DDI-6797100 https://reactome.org/PathwayBrowser/#/R-DDI-6797100 CCNK binds CDK13 IEA Dictyostelium discoideum DDB_G0278487 R-DDI-6797606 https://reactome.org/PathwayBrowser/#/R-DDI-6797606 CDK12 phosphorylates RNA Pol II CTD at DNA repair genes IEA Dictyostelium discoideum DDB_G0278487 R-DDI-6797616 https://reactome.org/PathwayBrowser/#/R-DDI-6797616 CCNK:CDK12 binds RNA Pol II at DNA repair genes IEA Dictyostelium discoideum DDB_G0278487 R-DDI-6800434 https://reactome.org/PathwayBrowser/#/R-DDI-6800434 Exocytosis of ficolin-rich granule lumen proteins IEA Dictyostelium discoideum DDB_G0278493 R-DDI-6788810 https://reactome.org/PathwayBrowser/#/R-DDI-6788810 AK6 phosphorylates (d)NMPs to (d)NDPs IEA Dictyostelium discoideum DDB_G0278539 R-DDI-156826 https://reactome.org/PathwayBrowser/#/R-DDI-156826 Dissociation of L13a from the 60s ribosomal subunit IEA Dictyostelium discoideum DDB_G0278539 R-DDI-1799332 https://reactome.org/PathwayBrowser/#/R-DDI-1799332 Nascent polypeptide:mRNA:ribosome complex binds signal recognition particle (SRP) IEA Dictyostelium discoideum DDB_G0278539 R-DDI-72671 https://reactome.org/PathwayBrowser/#/R-DDI-72671 eIF5B:GTP is hydrolyzed and released IEA Dictyostelium discoideum DDB_G0278539 R-DDI-72672 https://reactome.org/PathwayBrowser/#/R-DDI-72672 The 60S subunit joins the translation initiation complex IEA Dictyostelium discoideum DDB_G0278539 R-DDI-72673 https://reactome.org/PathwayBrowser/#/R-DDI-72673 Release of 40S and 60S subunits from the 80S ribosome IEA Dictyostelium discoideum DDB_G0278539 R-DDI-927789 https://reactome.org/PathwayBrowser/#/R-DDI-927789 Formation of UPF1:eRF3 complex on mRNA with a premature termination codon and no Exon Junction Complex IEA Dictyostelium discoideum DDB_G0278539 R-DDI-927832 https://reactome.org/PathwayBrowser/#/R-DDI-927832 UPF1 binds an mRNP with a termination codon preceding an Exon Junction Complex IEA Dictyostelium discoideum DDB_G0278539 R-DDI-927889 https://reactome.org/PathwayBrowser/#/R-DDI-927889 SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex) IEA Dictyostelium discoideum DDB_G0278541 R-DDI-1482533 https://reactome.org/PathwayBrowser/#/R-DDI-1482533 2-acyl LPC is acylated to PC by LPCAT IEA Dictyostelium discoideum DDB_G0278541 R-DDI-1482547 https://reactome.org/PathwayBrowser/#/R-DDI-1482547 1-acyl LPC is acylated to PC by LPCAT IEA Dictyostelium discoideum DDB_G0278541 R-DDI-1482598 https://reactome.org/PathwayBrowser/#/R-DDI-1482598 1-acyl LPI is acylated to PI by MBOAT7 IEA Dictyostelium discoideum DDB_G0278541 R-DDI-1482626 https://reactome.org/PathwayBrowser/#/R-DDI-1482626 2-acyl LPI is acylated to PI by MBOAT7 IEA Dictyostelium discoideum DDB_G0278541 R-DDI-1482636 https://reactome.org/PathwayBrowser/#/R-DDI-1482636 1-acyl LPS is acylated to PS by LPSAT IEA Dictyostelium discoideum DDB_G0278541 R-DDI-1482646 https://reactome.org/PathwayBrowser/#/R-DDI-1482646 2-acyl LPE is acylated to PE by LPEAT IEA Dictyostelium discoideum DDB_G0278541 R-DDI-1482667 https://reactome.org/PathwayBrowser/#/R-DDI-1482667 1-acyl LPE is acylated to PE by LPEAT IEA Dictyostelium discoideum DDB_G0278541 R-DDI-1482691 https://reactome.org/PathwayBrowser/#/R-DDI-1482691 2-acyl LPS is acylated to PS by LPSAT IEA Dictyostelium discoideum DDB_G0278563 R-DDI-6798745 https://reactome.org/PathwayBrowser/#/R-DDI-6798745 Exocytosis of tertiary granule lumen proteins IEA Dictyostelium discoideum DDB_G0278563 R-DDI-6798749 https://reactome.org/PathwayBrowser/#/R-DDI-6798749 Exocytosis of specific granule lumen proteins IEA Dictyostelium discoideum DDB_G0278563 R-DDI-6798751 https://reactome.org/PathwayBrowser/#/R-DDI-6798751 Exocytosis of azurophil granule lumen proteins IEA Dictyostelium discoideum DDB_G0278563 R-DDI-8862300 https://reactome.org/PathwayBrowser/#/R-DDI-8862300 LYZ binds bacterial peptidoglycan IEA Dictyostelium discoideum DDB_G0278563 R-DDI-8862320 https://reactome.org/PathwayBrowser/#/R-DDI-8862320 LYZ hydrolyzes peptidoglycans in the bacterial cell wall IEA Dictyostelium discoideum DDB_G0278579 R-DDI-6809003 https://reactome.org/PathwayBrowser/#/R-DDI-6809003 ERGIC-to-Golgi vesicles bind dynein:dynactin IEA Dictyostelium discoideum DDB_G0278607 R-DDI-191414 https://reactome.org/PathwayBrowser/#/R-DDI-191414 MVD decarboxylates MVA5PP to IPPP IEA Dictyostelium discoideum DDB_G0278613 R-DDI-2328033 https://reactome.org/PathwayBrowser/#/R-DDI-2328033 Fibrillin-1 binds latent TGF-beta IEA Dictyostelium discoideum DDB_G0278621 R-DDI-426032 https://reactome.org/PathwayBrowser/#/R-DDI-426032 DAG is metabolized by DAGL to 2-AG IEA Dictyostelium discoideum DDB_G0278639 R-DDI-2730692 https://reactome.org/PathwayBrowser/#/R-DDI-2730692 CLCN4/5/6 exchange Cl- for H+ IEA Dictyostelium discoideum DDB_G0278643 R-DDI-5694409 https://reactome.org/PathwayBrowser/#/R-DDI-5694409 Nucleotide exchange on RAB1 IEA Dictyostelium discoideum DDB_G0278643 R-DDI-5694439 https://reactome.org/PathwayBrowser/#/R-DDI-5694439 COPII coat binds TRAPPCII and RAB1:GDP IEA Dictyostelium discoideum DDB_G0278643 R-DDI-5694441 https://reactome.org/PathwayBrowser/#/R-DDI-5694441 CSNK1D phosphorylates SEC23 IEA Dictyostelium discoideum DDB_G0278643 R-DDI-8877475 https://reactome.org/PathwayBrowser/#/R-DDI-8877475 TRAPPC complexes exchange GTP for GDP on RAB1 IEA Dictyostelium discoideum DDB_G0278651 R-DDI-6799581 https://reactome.org/PathwayBrowser/#/R-DDI-6799581 MAN2B2 hydrolyses GlcNAc (Man)3 to GlcNAc:Man IEA Dictyostelium discoideum DDB_G0278653 R-DDI-6799581 https://reactome.org/PathwayBrowser/#/R-DDI-6799581 MAN2B2 hydrolyses GlcNAc (Man)3 to GlcNAc:Man IEA Dictyostelium discoideum DDB_G0278671 R-DDI-8952039 https://reactome.org/PathwayBrowser/#/R-DDI-8952039 NEDD8:AcM-UBE2F binds CRL5 E3 ubiquitin ligase complex IEA Dictyostelium discoideum DDB_G0278671 R-DDI-8952044 https://reactome.org/PathwayBrowser/#/R-DDI-8952044 AcM-UBE2F transfers NEDD8 to CRL5 E3 ubiquitin ligase complex IEA Dictyostelium discoideum DDB_G0278671 R-DDI-8955241 https://reactome.org/PathwayBrowser/#/R-DDI-8955241 CAND1 binds cytosolic CRL E3 ubiquitin ligases IEA Dictyostelium discoideum DDB_G0278671 R-DDI-8955289 https://reactome.org/PathwayBrowser/#/R-DDI-8955289 COMMDs displace CAND1 from cytosolic CRL E3 ubiquitin ligase complexes IEA Dictyostelium discoideum DDB_G0278671 R-DDI-8956040 https://reactome.org/PathwayBrowser/#/R-DDI-8956040 COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes IEA Dictyostelium discoideum DDB_G0278671 R-DDI-983140 https://reactome.org/PathwayBrowser/#/R-DDI-983140 Transfer of Ub from E2 to substrate and release of E2 IEA Dictyostelium discoideum DDB_G0278671 R-DDI-983147 https://reactome.org/PathwayBrowser/#/R-DDI-983147 Release of E3 from polyubiquitinated substrate IEA Dictyostelium discoideum DDB_G0278671 R-DDI-983156 https://reactome.org/PathwayBrowser/#/R-DDI-983156 Polyubiquitination of substrate IEA Dictyostelium discoideum DDB_G0278671 R-DDI-983157 https://reactome.org/PathwayBrowser/#/R-DDI-983157 Interaction of E3 with substrate and E2-Ub complex IEA Dictyostelium discoideum DDB_G0278673 R-DDI-8944454 https://reactome.org/PathwayBrowser/#/R-DDI-8944454 mTORC1 phosphorylates MAF1 IEA Dictyostelium discoideum DDB_G0278673 R-DDI-8944457 https://reactome.org/PathwayBrowser/#/R-DDI-8944457 MAF1 translocates to the nucleus IEA Dictyostelium discoideum DDB_G0278683 R-DDI-5676637 https://reactome.org/PathwayBrowser/#/R-DDI-5676637 PTPLs dehydrate VLC3HA-CoA to VLCTDA-CoA IEA Dictyostelium discoideum DDB_G0278685 R-DDI-8867613 https://reactome.org/PathwayBrowser/#/R-DDI-8867613 PICALM binds R-SNAREs IEA Dictyostelium discoideum DDB_G0278685 R-DDI-8868072 https://reactome.org/PathwayBrowser/#/R-DDI-8868072 Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2 IEA Dictyostelium discoideum DDB_G0278701 R-DDI-2172666 https://reactome.org/PathwayBrowser/#/R-DDI-2172666 RB1 binds condensin II IEA Dictyostelium discoideum DDB_G0278701 R-DDI-2288097 https://reactome.org/PathwayBrowser/#/R-DDI-2288097 Condensin II complex binds H4K20me1-containing nucleosomes IEA Dictyostelium discoideum DDB_G0278701 R-DDI-2294580 https://reactome.org/PathwayBrowser/#/R-DDI-2294580 PLK1 hyperphosphorylates Condensin II complex IEA Dictyostelium discoideum DDB_G0278701 R-DDI-2294590 https://reactome.org/PathwayBrowser/#/R-DDI-2294590 PLK1 binds phosphorylated condensin II complex IEA Dictyostelium discoideum DDB_G0278711 R-DDI-5690808 https://reactome.org/PathwayBrowser/#/R-DDI-5690808 UCHL3, SENP8 cleave NEDD8 IEA Dictyostelium discoideum DDB_G0278711 R-DDI-5691108 https://reactome.org/PathwayBrowser/#/R-DDI-5691108 SKP1:FBXL5:CUL1:NEDD8 ubiquitinylates IREB2 IEA Dictyostelium discoideum DDB_G0278711 R-DDI-8863723 https://reactome.org/PathwayBrowser/#/R-DDI-8863723 COP9 and TOR1 deneddylate STON2 IEA Dictyostelium discoideum DDB_G0278711 R-DDI-8863727 https://reactome.org/PathwayBrowser/#/R-DDI-8863727 STON2 is neddylated IEA Dictyostelium discoideum DDB_G0278711 R-DDI-8951644 https://reactome.org/PathwayBrowser/#/R-DDI-8951644 Release of mature NEDD8 IEA Dictyostelium discoideum DDB_G0278711 R-DDI-8951648 https://reactome.org/PathwayBrowser/#/R-DDI-8951648 NEDD8 covalently binds catalytic cysteine of UBA3:NAE1 IEA Dictyostelium discoideum DDB_G0278711 R-DDI-8951656 https://reactome.org/PathwayBrowser/#/R-DDI-8951656 NEDD8-UBA3:NAE1 binds a second NEDD8 IEA Dictyostelium discoideum DDB_G0278711 R-DDI-8951661 https://reactome.org/PathwayBrowser/#/R-DDI-8951661 Transfer of NEDD8 to AcM-UBE2M IEA Dictyostelium discoideum DDB_G0278711 R-DDI-8951751 https://reactome.org/PathwayBrowser/#/R-DDI-8951751 Doubly neddylated UBA3:NAE1 binds AcM-UBE2M IEA Dictyostelium discoideum DDB_G0278711 R-DDI-8951764 https://reactome.org/PathwayBrowser/#/R-DDI-8951764 Transfer of NEDD8 to AcM-UBE2F IEA Dictyostelium discoideum DDB_G0278711 R-DDI-8951766 https://reactome.org/PathwayBrowser/#/R-DDI-8951766 Doubly neddylated UBA3:NAE1 binds AcM-UBE2F IEA Dictyostelium discoideum DDB_G0278711 R-DDI-8952039 https://reactome.org/PathwayBrowser/#/R-DDI-8952039 NEDD8:AcM-UBE2F binds CRL5 E3 ubiquitin ligase complex IEA Dictyostelium discoideum DDB_G0278711 R-DDI-8952044 https://reactome.org/PathwayBrowser/#/R-DDI-8952044 AcM-UBE2F transfers NEDD8 to CRL5 E3 ubiquitin ligase complex IEA Dictyostelium discoideum DDB_G0278711 R-DDI-8952618 https://reactome.org/PathwayBrowser/#/R-DDI-8952618 AcM-UBE2M transfers NEDD8 to CRL1 E3 ubiquitin ligase complex IEA Dictyostelium discoideum DDB_G0278711 R-DDI-8952620 https://reactome.org/PathwayBrowser/#/R-DDI-8952620 NEDD8:AcM-UBE2M binds CRL1 E3 ubiquitin ligase complex IEA Dictyostelium discoideum DDB_G0278711 R-DDI-8952626 https://reactome.org/PathwayBrowser/#/R-DDI-8952626 AcM-UBE2M transfers NEDD8 to CRL2 E3 ubiquitin ligase complex IEA Dictyostelium discoideum DDB_G0278711 R-DDI-8952630 https://reactome.org/PathwayBrowser/#/R-DDI-8952630 NEDD8:AcM-UBE2M binds CRL3 E3 ubiquitin ligase complex IEA Dictyostelium discoideum DDB_G0278711 R-DDI-8952631 https://reactome.org/PathwayBrowser/#/R-DDI-8952631 AcM-UBE2M transfers NEDD8 to CRL3 E3 ubiquitin ligase complex IEA Dictyostelium discoideum DDB_G0278711 R-DDI-8952638 https://reactome.org/PathwayBrowser/#/R-DDI-8952638 AcM-UBE2M transfers NEDD8 to CRL4 E3 ubiquitin ligase complex IEA Dictyostelium discoideum DDB_G0278711 R-DDI-8952639 https://reactome.org/PathwayBrowser/#/R-DDI-8952639 NEDD8:AcM-UBE2M binds CRL4 E3 ubiquitin ligase complex IEA Dictyostelium discoideum DDB_G0278711 R-DDI-8956040 https://reactome.org/PathwayBrowser/#/R-DDI-8956040 COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes IEA Dictyostelium discoideum DDB_G0278711 R-DDI-8956045 https://reactome.org/PathwayBrowser/#/R-DDI-8956045 COP9 signalosome deneddylates nuclear CRL4 E3 ubiquitin ligase complex IEA Dictyostelium discoideum DDB_G0278721 R-DDI-1566981 https://reactome.org/PathwayBrowser/#/R-DDI-1566981 Fibronectin degradation by MMP1, 3, 7, 12, 13, 19, CTSS IEA Dictyostelium discoideum DDB_G0278721 R-DDI-2130706 https://reactome.org/PathwayBrowser/#/R-DDI-2130706 MHC class II antigen processing IEA Dictyostelium discoideum DDB_G0278721 R-DDI-6798745 https://reactome.org/PathwayBrowser/#/R-DDI-6798745 Exocytosis of tertiary granule lumen proteins IEA Dictyostelium discoideum DDB_G0278721 R-DDI-6800434 https://reactome.org/PathwayBrowser/#/R-DDI-6800434 Exocytosis of ficolin-rich granule lumen proteins IEA Dictyostelium discoideum DDB_G0278727 R-DDI-1675928 https://reactome.org/PathwayBrowser/#/R-DDI-1675928 PI4P is phosphorylated to PI(3,4)P2 by PIK3C2A/G at the Golgi membrane IEA Dictyostelium discoideum DDB_G0278727 R-DDI-1675939 https://reactome.org/PathwayBrowser/#/R-DDI-1675939 PI is phosphorylated to PI3P by PIK3C2A/3 at the early endosome membrane IEA Dictyostelium discoideum DDB_G0278727 R-DDI-1675961 https://reactome.org/PathwayBrowser/#/R-DDI-1675961 PI is phosphorylated to PI3P by PIK3C2A/3 at the Golgi membrane IEA Dictyostelium discoideum DDB_G0278727 R-DDI-1676024 https://reactome.org/PathwayBrowser/#/R-DDI-1676024 PI is phosphorylated to PI3P by PIK3C2A/3 at the late endosome membrane IEA Dictyostelium discoideum DDB_G0278727 R-DDI-1676048 https://reactome.org/PathwayBrowser/#/R-DDI-1676048 PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane IEA Dictyostelium discoideum DDB_G0278727 R-DDI-1676109 https://reactome.org/PathwayBrowser/#/R-DDI-1676109 PI4P is phosphorylated to PI(3,4)P2 by PI3K3C[2] at the plasma membrane IEA Dictyostelium discoideum DDB_G0278727 R-DDI-1676206 https://reactome.org/PathwayBrowser/#/R-DDI-1676206 PI4P is phosphorylated to PI(3,4)P2 by PIK3C2A at the early endosome membrane IEA Dictyostelium discoideum DDB_G0278727 R-DDI-392300 https://reactome.org/PathwayBrowser/#/R-DDI-392300 G beta:gamma activated PI3Kgamma converts PIP2 to PIP3 IEA Dictyostelium discoideum DDB_G0278727 R-DDI-437162 https://reactome.org/PathwayBrowser/#/R-DDI-437162 PI3K alpha, beta, gamma convert PIP2 to PIP3 IEA Dictyostelium discoideum DDB_G0278727 R-DDI-8868072 https://reactome.org/PathwayBrowser/#/R-DDI-8868072 Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2 IEA Dictyostelium discoideum DDB_G0278729 R-DDI-109639 https://reactome.org/PathwayBrowser/#/R-DDI-109639 Formation of the closed pre-initiation complex IEA Dictyostelium discoideum DDB_G0278729 R-DDI-111264 https://reactome.org/PathwayBrowser/#/R-DDI-111264 Addition of nucleotides between position +11 and +30 IEA Dictyostelium discoideum DDB_G0278729 R-DDI-112383 https://reactome.org/PathwayBrowser/#/R-DDI-112383 Hypophosphorylation of RNA Pol II CTD by FCP1P protein IEA Dictyostelium discoideum DDB_G0278729 R-DDI-113430 https://reactome.org/PathwayBrowser/#/R-DDI-113430 Extrusion of 5'-end of 30 nt long transcript through the pore in Pol II complex IEA Dictyostelium discoideum DDB_G0278729 R-DDI-5690996 https://reactome.org/PathwayBrowser/#/R-DDI-5690996 ERCC2 and ERCC3 DNA helicases form an open bubble structure in damaged DNA IEA Dictyostelium discoideum DDB_G0278729 R-DDI-5691000 https://reactome.org/PathwayBrowser/#/R-DDI-5691000 TFIIH binds GG-NER site to form a verification complex IEA Dictyostelium discoideum DDB_G0278729 R-DDI-6781818 https://reactome.org/PathwayBrowser/#/R-DDI-6781818 RNA Pol II initiates transcription from damaged DNA template IEA Dictyostelium discoideum DDB_G0278729 R-DDI-6781824 https://reactome.org/PathwayBrowser/#/R-DDI-6781824 Active RNA Pol II complex transcribes lesion-containing DNA template IEA Dictyostelium discoideum DDB_G0278729 R-DDI-6781833 https://reactome.org/PathwayBrowser/#/R-DDI-6781833 ERCC8 (CSA) binds stalled RNA Pol II IEA Dictyostelium discoideum DDB_G0278729 R-DDI-6781840 https://reactome.org/PathwayBrowser/#/R-DDI-6781840 ERCC6 binds stalled RNA Pol II IEA Dictyostelium discoideum DDB_G0278729 R-DDI-6781867 https://reactome.org/PathwayBrowser/#/R-DDI-6781867 ERCC8:DDB1:CUL4:RBX1 ubiquitinates ERCC6 and RNA Pol II IEA Dictyostelium discoideum DDB_G0278729 R-DDI-6782069 https://reactome.org/PathwayBrowser/#/R-DDI-6782069 UVSSA:USP7 deubiquitinates ERCC6 IEA Dictyostelium discoideum DDB_G0278729 R-DDI-6782131 https://reactome.org/PathwayBrowser/#/R-DDI-6782131 ERCC2-facilitated RNA Pol II backtracking in TC-NER IEA Dictyostelium discoideum DDB_G0278729 R-DDI-6782141 https://reactome.org/PathwayBrowser/#/R-DDI-6782141 Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in TC-NER IEA Dictyostelium discoideum DDB_G0278729 R-DDI-6782204 https://reactome.org/PathwayBrowser/#/R-DDI-6782204 5' incision of damaged DNA strand by ERCC1:ERCC4 in TC-NER IEA Dictyostelium discoideum DDB_G0278729 R-DDI-6782208 https://reactome.org/PathwayBrowser/#/R-DDI-6782208 Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in TC-NER IEA Dictyostelium discoideum DDB_G0278729 R-DDI-6782211 https://reactome.org/PathwayBrowser/#/R-DDI-6782211 DNA polymerases delta, epsilon or kappa bind the TC-NER site IEA Dictyostelium discoideum DDB_G0278729 R-DDI-6782227 https://reactome.org/PathwayBrowser/#/R-DDI-6782227 Ligation of newly synthesized repair patch to incised DNA in TC-NER IEA Dictyostelium discoideum DDB_G0278729 R-DDI-6797606 https://reactome.org/PathwayBrowser/#/R-DDI-6797606 CDK12 phosphorylates RNA Pol II CTD at DNA repair genes IEA Dictyostelium discoideum DDB_G0278729 R-DDI-6797616 https://reactome.org/PathwayBrowser/#/R-DDI-6797616 CCNK:CDK12 binds RNA Pol II at DNA repair genes IEA Dictyostelium discoideum DDB_G0278729 R-DDI-73769 https://reactome.org/PathwayBrowser/#/R-DDI-73769 Loss of Rrn3 from RNA Polymerase I promoter escape complex IEA Dictyostelium discoideum DDB_G0278729 R-DDI-73946 https://reactome.org/PathwayBrowser/#/R-DDI-73946 Abortive initiation after formation of the first phosphodiester bond IEA Dictyostelium discoideum DDB_G0278729 R-DDI-74986 https://reactome.org/PathwayBrowser/#/R-DDI-74986 Elongation of pre-rRNA transcript IEA Dictyostelium discoideum DDB_G0278729 R-DDI-75850 https://reactome.org/PathwayBrowser/#/R-DDI-75850 Addition of the third nucleotide on the nascent transcript IEA Dictyostelium discoideum DDB_G0278729 R-DDI-75856 https://reactome.org/PathwayBrowser/#/R-DDI-75856 Abortive Initiation Before Second Transition IEA Dictyostelium discoideum DDB_G0278729 R-DDI-75861 https://reactome.org/PathwayBrowser/#/R-DDI-75861 NTP Binds Active Site of RNA Polymerase II IEA Dictyostelium discoideum DDB_G0278729 R-DDI-75862 https://reactome.org/PathwayBrowser/#/R-DDI-75862 Fall Back to Closed Pre-initiation Complex IEA Dictyostelium discoideum DDB_G0278729 R-DDI-75864 https://reactome.org/PathwayBrowser/#/R-DDI-75864 Newly Formed Phosphodiester Bond Stabilized and PPi Released IEA Dictyostelium discoideum DDB_G0278729 R-DDI-75866 https://reactome.org/PathwayBrowser/#/R-DDI-75866 Nucleophillic Attack by 3'-hydroxyl Oxygen of nascent transcript on the Alpha Phosphate of NTP IEA Dictyostelium discoideum DDB_G0278729 R-DDI-75869 https://reactome.org/PathwayBrowser/#/R-DDI-75869 Addition of the fourth nucleotide on the Nascent Transcript: Second Transition IEA Dictyostelium discoideum DDB_G0278729 R-DDI-75873 https://reactome.org/PathwayBrowser/#/R-DDI-75873 Addition of Nucleotides 5 through 9 on the growing Transcript IEA Dictyostelium discoideum DDB_G0278729 R-DDI-75891 https://reactome.org/PathwayBrowser/#/R-DDI-75891 Abortive Initiation After Second Transition IEA Dictyostelium discoideum DDB_G0278729 R-DDI-75949 https://reactome.org/PathwayBrowser/#/R-DDI-75949 RNA Polymerase II Promoter Opening: First Transition IEA Dictyostelium discoideum DDB_G0278729 R-DDI-76576 https://reactome.org/PathwayBrowser/#/R-DDI-76576 Addition of nucleotides 10 and 11 on the growing transcript: Third Transition IEA Dictyostelium discoideum DDB_G0278729 R-DDI-77068 https://reactome.org/PathwayBrowser/#/R-DDI-77068 Activation of GT IEA Dictyostelium discoideum DDB_G0278729 R-DDI-77069 https://reactome.org/PathwayBrowser/#/R-DDI-77069 RNA Polymerase II CTD (phosphorylated) binds to CE IEA Dictyostelium discoideum DDB_G0278729 R-DDI-77071 https://reactome.org/PathwayBrowser/#/R-DDI-77071 Phosphorylation (Ser5) of RNA pol II CTD IEA Dictyostelium discoideum DDB_G0278729 R-DDI-77073 https://reactome.org/PathwayBrowser/#/R-DDI-77073 SPT5 subunit of Pol II binds the RNA triphosphatase (RTP) IEA Dictyostelium discoideum DDB_G0278729 R-DDI-77077 https://reactome.org/PathwayBrowser/#/R-DDI-77077 Capping complex formation IEA Dictyostelium discoideum DDB_G0278729 R-DDI-77078 https://reactome.org/PathwayBrowser/#/R-DDI-77078 Hydrolysis of the 5'-end of the nascent transcript by the capping enzyme IEA Dictyostelium discoideum DDB_G0278729 R-DDI-77081 https://reactome.org/PathwayBrowser/#/R-DDI-77081 Formation of the CE:GMP intermediate complex IEA Dictyostelium discoideum DDB_G0278729 R-DDI-77083 https://reactome.org/PathwayBrowser/#/R-DDI-77083 Transfer of GMP from the capping enzyme GT site to 5'-end of mRNA IEA Dictyostelium discoideum DDB_G0278729 R-DDI-77085 https://reactome.org/PathwayBrowser/#/R-DDI-77085 Dissociation of transcript with 5'-GMP from GT IEA Dictyostelium discoideum DDB_G0278729 R-DDI-77090 https://reactome.org/PathwayBrowser/#/R-DDI-77090 Methylation of GMP-cap by RNA Methyltransferase IEA Dictyostelium discoideum DDB_G0278729 R-DDI-9613494 https://reactome.org/PathwayBrowser/#/R-DDI-9613494 Unwinding of DNA for the Nascent Transcript: Second Transition IEA Dictyostelium discoideum DDB_G0278729 R-DDI-9613497 https://reactome.org/PathwayBrowser/#/R-DDI-9613497 Unwinding DNA for the nascent transcript IEA Dictyostelium discoideum DDB_G0278729 R-DDI-9684118 https://reactome.org/PathwayBrowser/#/R-DDI-9684118 ERCC3-facilitated RNA Pol II backtracking in TC-NER IEA Dictyostelium discoideum DDB_G0278733 R-DDI-482772 https://reactome.org/PathwayBrowser/#/R-DDI-482772 Release of platelet cytosolic components IEA Dictyostelium discoideum DDB_G0278735 R-DDI-191303 https://reactome.org/PathwayBrowser/#/R-DDI-191303 FDPS dimer transfers IPPP to GPP IEA Dictyostelium discoideum DDB_G0278735 R-DDI-191322 https://reactome.org/PathwayBrowser/#/R-DDI-191322 FDPS dimer transfers IPPP to DMAPP IEA Dictyostelium discoideum DDB_G0278735 R-DDI-9717841 https://reactome.org/PathwayBrowser/#/R-DDI-9717841 holo-FDPS dimer binds NBPs IEA Dictyostelium discoideum DDB_G0278739 R-DDI-1855157 https://reactome.org/PathwayBrowser/#/R-DDI-1855157 1-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by IP6K1/2 in the nucleus IEA Dictyostelium discoideum DDB_G0278739 R-DDI-1855158 https://reactome.org/PathwayBrowser/#/R-DDI-1855158 5-PP-IP5 is phosphorylated to 5-PPP-IP5 by IP6K1/3 in the cytosol IEA Dictyostelium discoideum DDB_G0278739 R-DDI-1855181 https://reactome.org/PathwayBrowser/#/R-DDI-1855181 I(1,3,4,5,6)P5 is phosphorylated to 5-PP-IP4 by IP6K1/2 in the nucleus IEA Dictyostelium discoideum DDB_G0278739 R-DDI-1855193 https://reactome.org/PathwayBrowser/#/R-DDI-1855193 1-PP-IP4 is phosphorylated to 1,5-(PP)2-IP3 by IP6K1/3 in the cytosol IEA Dictyostelium discoideum DDB_G0278739 R-DDI-1855194 https://reactome.org/PathwayBrowser/#/R-DDI-1855194 1-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by IP6K1/3 in the cytosol IEA Dictyostelium discoideum DDB_G0278739 R-DDI-1855207 https://reactome.org/PathwayBrowser/#/R-DDI-1855207 IP6 is phosphorylated to 5-PP-IP5 by IP6K1/2 in the nucleus IEA Dictyostelium discoideum DDB_G0278739 R-DDI-1855223 https://reactome.org/PathwayBrowser/#/R-DDI-1855223 I(1,3,4,5,6)P5 is phosphorylated to 5-PP-IP4 by IP6K1/3 in the cytosol IEA Dictyostelium discoideum DDB_G0278739 R-DDI-1855224 https://reactome.org/PathwayBrowser/#/R-DDI-1855224 5-PP-IP5 is phosphorylated to 5-PPP-IP5 by IP6K1/2 in the nucleus IEA Dictyostelium discoideum DDB_G0278739 R-DDI-1855227 https://reactome.org/PathwayBrowser/#/R-DDI-1855227 IP6 is phosphorylated to 5-PP-IP5 by IP6K1/3 in the cytosol IEA Dictyostelium discoideum DDB_G0278739 R-DDI-1855230 https://reactome.org/PathwayBrowser/#/R-DDI-1855230 5-PP-IP4 is phosphorylated to 1,5-(PP)2-IP3 by IP6K1/2 in the nucleus IEA Dictyostelium discoideum DDB_G0278741 R-DDI-5649873 https://reactome.org/PathwayBrowser/#/R-DDI-5649873 PARP1,PARP2 dimers and FEN1 bind POLB and displace APEX1 from damaged AP site IEA Dictyostelium discoideum DDB_G0278741 R-DDI-5649883 https://reactome.org/PathwayBrowser/#/R-DDI-5649883 POLB-mediated DNA strand displacement synthesis IEA Dictyostelium discoideum DDB_G0278741 R-DDI-5651723 https://reactome.org/PathwayBrowser/#/R-DDI-5651723 PARP1,PARP2 dimers bound to FEN1 and POLB autoPARylate IEA Dictyostelium discoideum DDB_G0278741 R-DDI-5651739 https://reactome.org/PathwayBrowser/#/R-DDI-5651739 PAR-PARP1,PAR-PARP2 dissociate from FEN1 and POLB IEA Dictyostelium discoideum DDB_G0278741 R-DDI-5651828 https://reactome.org/PathwayBrowser/#/R-DDI-5651828 PARG dePARylates PARP1,PARP2 IEA Dictyostelium discoideum DDB_G0278741 R-DDI-5690996 https://reactome.org/PathwayBrowser/#/R-DDI-5690996 ERCC2 and ERCC3 DNA helicases form an open bubble structure in damaged DNA IEA Dictyostelium discoideum DDB_G0278741 R-DDI-5691000 https://reactome.org/PathwayBrowser/#/R-DDI-5691000 TFIIH binds GG-NER site to form a verification complex IEA Dictyostelium discoideum DDB_G0278741 R-DDI-5696655 https://reactome.org/PathwayBrowser/#/R-DDI-5696655 PARP1 or PARP2 PARylates DDB2 and autoPARylates IEA Dictyostelium discoideum DDB_G0278741 R-DDI-5696664 https://reactome.org/PathwayBrowser/#/R-DDI-5696664 PARP1 or PARP2 binds DDB2 at GG-NER site IEA Dictyostelium discoideum DDB_G0278751 R-DDI-6791222 https://reactome.org/PathwayBrowser/#/R-DDI-6791222 21S pre-rRNA is nucleolytically processed at site E (site2a) to yield 18SE pre-rRNA IEA Dictyostelium discoideum DDB_G0278751 R-DDI-6791227 https://reactome.org/PathwayBrowser/#/R-DDI-6791227 47S pre-rRNA is nucleolytically processed at A' (01,A1), site A0, and site 02 (site 6) to yield 45S pre-rRNA IEA Dictyostelium discoideum DDB_G0278753 R-DDI-428259 https://reactome.org/PathwayBrowser/#/R-DDI-428259 DEGS1 dehydrogenates dihydroceramide IEA Dictyostelium discoideum DDB_G0278753 R-DDI-428260 https://reactome.org/PathwayBrowser/#/R-DDI-428260 DEGS2 oxygenates dihydroceramide IEA Dictyostelium discoideum DDB_G0278753 R-DDI-5693761 https://reactome.org/PathwayBrowser/#/R-DDI-5693761 FA2H hydroxylates 1,2-saturated fatty acids IEA Dictyostelium discoideum DDB_G0278753 R-DDI-8936442 https://reactome.org/PathwayBrowser/#/R-DDI-8936442 MARC1,MARC2 reduce N-hydroxylated compounds IEA Dictyostelium discoideum DDB_G0278769 R-DDI-77590 https://reactome.org/PathwayBrowser/#/R-DDI-77590 Recruitment of CstF to the CPSF Bound Pre-mRNA IEA Dictyostelium discoideum DDB_G0278773 R-DDI-6798739 https://reactome.org/PathwayBrowser/#/R-DDI-6798739 Exocytosis of azurophil granule membrane proteins IEA Dictyostelium discoideum DDB_G0278773 R-DDI-9609921 https://reactome.org/PathwayBrowser/#/R-DDI-9609921 SGTA binds Tail-anchored protein IEA Dictyostelium discoideum DDB_G0278775 R-DDI-141423 https://reactome.org/PathwayBrowser/#/R-DDI-141423 Binding of the MCC complex to the APC/C complex IEA Dictyostelium discoideum DDB_G0278775 R-DDI-174057 https://reactome.org/PathwayBrowser/#/R-DDI-174057 Multiubiquitination of APC/C-associated Cdh1 IEA Dictyostelium discoideum DDB_G0278775 R-DDI-174058 https://reactome.org/PathwayBrowser/#/R-DDI-174058 Degradation of multiubiquitinated Cdh1 IEA Dictyostelium discoideum DDB_G0278775 R-DDI-174070 https://reactome.org/PathwayBrowser/#/R-DDI-174070 Association of Cdh1 with the APC/C IEA Dictyostelium discoideum DDB_G0278775 R-DDI-174079 https://reactome.org/PathwayBrowser/#/R-DDI-174079 Phosphorylation of Cdh1 by Cyclin A:Cdk2 IEA Dictyostelium discoideum DDB_G0278775 R-DDI-174088 https://reactome.org/PathwayBrowser/#/R-DDI-174088 Association of cell cycle proteins with the APC/C:Cdh1 complex IEA Dictyostelium discoideum DDB_G0278775 R-DDI-174104 https://reactome.org/PathwayBrowser/#/R-DDI-174104 Ubiquitination of Cyclin A by APC/C:Cdc20 complex IEA Dictyostelium discoideum DDB_G0278775 R-DDI-174105 https://reactome.org/PathwayBrowser/#/R-DDI-174105 Degradation of multiubiquitinated cell cycle proteins IEA Dictyostelium discoideum DDB_G0278775 R-DDI-174119 https://reactome.org/PathwayBrowser/#/R-DDI-174119 Free APC/C phosphorylated by Plk1 IEA Dictyostelium discoideum DDB_G0278775 R-DDI-174139 https://reactome.org/PathwayBrowser/#/R-DDI-174139 Dissociation of phospho-Cdh1 from the APC/C complex IEA Dictyostelium discoideum DDB_G0278775 R-DDI-174144 https://reactome.org/PathwayBrowser/#/R-DDI-174144 Ubiquitination of Securin by phospho-APC/C:Cdc20 complex IEA Dictyostelium discoideum DDB_G0278775 R-DDI-174195 https://reactome.org/PathwayBrowser/#/R-DDI-174195 Ubiquitination of cell cycle proteins targeted by the APC/C:Cdh1complex IEA Dictyostelium discoideum DDB_G0278775 R-DDI-174202 https://reactome.org/PathwayBrowser/#/R-DDI-174202 Degradation of multiubiquitinated Securin IEA Dictyostelium discoideum DDB_G0278775 R-DDI-174224 https://reactome.org/PathwayBrowser/#/R-DDI-174224 Dissociation of Cdc20 from APC/C complex IEA Dictyostelium discoideum DDB_G0278775 R-DDI-174227 https://reactome.org/PathwayBrowser/#/R-DDI-174227 Ubiquitination of Cyclin B by phospho-APC/C:Cdc20 complex IEA Dictyostelium discoideum DDB_G0278775 R-DDI-174238 https://reactome.org/PathwayBrowser/#/R-DDI-174238 Activation of APC/C:Cdc20 by dissociation of Cdc20:phospho-APC/C from Cdc20:phospho-APC/C:Mad2:Bub3:BubR1 IEA Dictyostelium discoideum DDB_G0278775 R-DDI-179410 https://reactome.org/PathwayBrowser/#/R-DDI-179410 Association of Nek2A with MCC:APC/C IEA Dictyostelium discoideum DDB_G0278775 R-DDI-179417 https://reactome.org/PathwayBrowser/#/R-DDI-179417 Multiubiquitination of Nek2A IEA Dictyostelium discoideum DDB_G0278775 R-DDI-179421 https://reactome.org/PathwayBrowser/#/R-DDI-179421 Degradation of multiubiquitinated Nek2A IEA Dictyostelium discoideum DDB_G0278775 R-DDI-188191 https://reactome.org/PathwayBrowser/#/R-DDI-188191 APC/C:Cdh1-mediated degradation of Skp2 IEA Dictyostelium discoideum DDB_G0278775 R-DDI-3788705 https://reactome.org/PathwayBrowser/#/R-DDI-3788705 CDKN1A (p21) prevents phosphorylation of Cdh1 by Cyclin A:Cdk2 IEA Dictyostelium discoideum DDB_G0278775 R-DDI-3788724 https://reactome.org/PathwayBrowser/#/R-DDI-3788724 Cdh1:APC/C ubiquitinates EHMT1 and EHMT2 IEA Dictyostelium discoideum DDB_G0278775 R-DDI-69015 https://reactome.org/PathwayBrowser/#/R-DDI-69015 Cytoplasmic phosphorylated Cdc6 is ubiquitinated by the anaphase-promoting complex IEA Dictyostelium discoideum DDB_G0278775 R-DDI-8852129 https://reactome.org/PathwayBrowser/#/R-DDI-8852129 UBA1 conjugates ubiquitin to cytosolic E2 enzymes IEA Dictyostelium discoideum DDB_G0278775 R-DDI-8852130 https://reactome.org/PathwayBrowser/#/R-DDI-8852130 UBA1 conjugates ubiquitin to nuclear E2 enzymes IEA Dictyostelium discoideum DDB_G0278775 R-DDI-9686969 https://reactome.org/PathwayBrowser/#/R-DDI-9686969 APC/C:Cdh1 polyubiquitinates SKP2 IEA Dictyostelium discoideum DDB_G0278775 R-DDI-983140 https://reactome.org/PathwayBrowser/#/R-DDI-983140 Transfer of Ub from E2 to substrate and release of E2 IEA Dictyostelium discoideum DDB_G0278775 R-DDI-983152 https://reactome.org/PathwayBrowser/#/R-DDI-983152 Transfer of ubiquitin from E1 to E2 IEA Dictyostelium discoideum DDB_G0278775 R-DDI-983156 https://reactome.org/PathwayBrowser/#/R-DDI-983156 Polyubiquitination of substrate IEA Dictyostelium discoideum DDB_G0278775 R-DDI-983157 https://reactome.org/PathwayBrowser/#/R-DDI-983157 Interaction of E3 with substrate and E2-Ub complex IEA Dictyostelium discoideum DDB_G0278779 R-DDI-70971 https://reactome.org/PathwayBrowser/#/R-DDI-70971 ACO2 isomerizes citrate IEA Dictyostelium discoideum DDB_G0278779 R-DDI-9838081 https://reactome.org/PathwayBrowser/#/R-DDI-9838081 LONP1 degrades mitochondrial matrix proteins IEA Dictyostelium discoideum DDB_G0278779 R-DDI-9838093 https://reactome.org/PathwayBrowser/#/R-DDI-9838093 LONP1 binds mitochondrial matrix proteins IEA Dictyostelium discoideum DDB_G0278779 R-DDI-9854368 https://reactome.org/PathwayBrowser/#/R-DDI-9854368 ROS,RNS oxidize ACO2:4Fe-4S IEA Dictyostelium discoideum DDB_G0278779 R-DDI-9854405 https://reactome.org/PathwayBrowser/#/R-DDI-9854405 Frataxin transfers Fe2+ to ACO2 IEA Dictyostelium discoideum DDB_G0278781 R-DDI-209823 https://reactome.org/PathwayBrowser/#/R-DDI-209823 Tyrosine is hydroxylated to dopa IEA Dictyostelium discoideum DDB_G0278781 R-DDI-209828 https://reactome.org/PathwayBrowser/#/R-DDI-209828 Tryptophan is hydroxylated IEA Dictyostelium discoideum DDB_G0278781 R-DDI-71118 https://reactome.org/PathwayBrowser/#/R-DDI-71118 PAH:Fe2+ tetramer hydroxylates L-Phe to L-Tyr IEA Dictyostelium discoideum DDB_G0278815 R-DDI-72671 https://reactome.org/PathwayBrowser/#/R-DDI-72671 eIF5B:GTP is hydrolyzed and released IEA Dictyostelium discoideum DDB_G0278815 R-DDI-72672 https://reactome.org/PathwayBrowser/#/R-DDI-72672 The 60S subunit joins the translation initiation complex IEA Dictyostelium discoideum DDB_G0278819 R-DDI-9770236 https://reactome.org/PathwayBrowser/#/R-DDI-9770236 Formation of the Spliceosomal P complex and exon ligation IEA Dictyostelium discoideum DDB_G0278821 R-DDI-111437 https://reactome.org/PathwayBrowser/#/R-DDI-111437 Cleavage of the 3'-end of the Histone Pre-mRNA IEA Dictyostelium discoideum DDB_G0278821 R-DDI-111438 https://reactome.org/PathwayBrowser/#/R-DDI-111438 Recruitment of U7 snRNP:ZFP100 complex to the Histone Pre-mRNA IEA Dictyostelium discoideum DDB_G0278821 R-DDI-77585 https://reactome.org/PathwayBrowser/#/R-DDI-77585 Recruitment of U7 snRNP:ZFP100 complex to the SLBP Bound Pre-mRNA IEA Dictyostelium discoideum DDB_G0278821 R-DDI-77586 https://reactome.org/PathwayBrowser/#/R-DDI-77586 Cleavage of the 3'-end of Replication Dependent Histone Pre-mRNA IEA Dictyostelium discoideum DDB_G0278821 R-DDI-9770236 https://reactome.org/PathwayBrowser/#/R-DDI-9770236 Formation of the Spliceosomal P complex and exon ligation IEA Dictyostelium discoideum DDB_G0278829 R-DDI-4827383 https://reactome.org/PathwayBrowser/#/R-DDI-4827383 WHSC1 (KMT3G), NSD1 (KMT3B), SMYD2 (KMT3C) methylate lysine-37 of histone H3 (H3K36) IEA Dictyostelium discoideum DDB_G0278829 R-DDI-5244692 https://reactome.org/PathwayBrowser/#/R-DDI-5244692 Core MLL complex, SMYD3, PRDM9 methylate dimethyl-lysine-5 of histone H3 (H3K4) IEA Dictyostelium discoideum DDB_G0278829 R-DDI-5637686 https://reactome.org/PathwayBrowser/#/R-DDI-5637686 WHSC1L1 (KMT3F), Core MLL complex, SMYD3 (KMT3E) methylate methyl-lysine-5 of histone H3 (H3K4) IEA Dictyostelium discoideum DDB_G0278829 R-DDI-5638157 https://reactome.org/PathwayBrowser/#/R-DDI-5638157 WHSC1 (KMT3G), NSD1 (KMT3B), SMYD2 (KMT3C), ASH1L methylate methyl-lysine-37 of histone H3 (H3K36) IEA Dictyostelium discoideum DDB_G0278843 R-DDI-109636 https://reactome.org/PathwayBrowser/#/R-DDI-109636 Recognition and Binding of Core Promoter Elements by TFIID IEA Dictyostelium discoideum DDB_G0278843 R-DDI-109637 https://reactome.org/PathwayBrowser/#/R-DDI-109637 Binding of TFIIA and TFIIB to the pol II promoter:TFIID complex IEA Dictyostelium discoideum DDB_G0278843 R-DDI-109638 https://reactome.org/PathwayBrowser/#/R-DDI-109638 Recruitment of RNA Polymerase II Holoenzyme by TFIIF to the pol II promoter:TFIID:TFIIA:TFIIB complex IEA Dictyostelium discoideum DDB_G0278843 R-DDI-109639 https://reactome.org/PathwayBrowser/#/R-DDI-109639 Formation of the closed pre-initiation complex IEA Dictyostelium discoideum DDB_G0278843 R-DDI-6810233 https://reactome.org/PathwayBrowser/#/R-DDI-6810233 CDK7 phosphorylates serine-5 and serine-7 of heptad repeats in C-terminal domain of RNA polymerase II at snRNA promoter IEA Dictyostelium discoideum DDB_G0278843 R-DDI-6810238 https://reactome.org/PathwayBrowser/#/R-DDI-6810238 RNA polymerase II binds initiation factors at promoter of snRNA gene (U1, U2, U4, U4atac, U5, U11, U12) IEA Dictyostelium discoideum DDB_G0278843 R-DDI-6814555 https://reactome.org/PathwayBrowser/#/R-DDI-6814555 Integrator complex processes the 3' end of snRNA IEA Dictyostelium discoideum DDB_G0278843 R-DDI-6814559 https://reactome.org/PathwayBrowser/#/R-DDI-6814559 Pre-snRNA is elongated and capped with 7-methylguanosine IEA Dictyostelium discoideum DDB_G0278843 R-DDI-73946 https://reactome.org/PathwayBrowser/#/R-DDI-73946 Abortive initiation after formation of the first phosphodiester bond IEA Dictyostelium discoideum DDB_G0278843 R-DDI-75095 https://reactome.org/PathwayBrowser/#/R-DDI-75095 Binding of TFIIE to the growing preinitiation complex IEA Dictyostelium discoideum DDB_G0278843 R-DDI-75850 https://reactome.org/PathwayBrowser/#/R-DDI-75850 Addition of the third nucleotide on the nascent transcript IEA Dictyostelium discoideum DDB_G0278843 R-DDI-75856 https://reactome.org/PathwayBrowser/#/R-DDI-75856 Abortive Initiation Before Second Transition IEA Dictyostelium discoideum DDB_G0278843 R-DDI-75861 https://reactome.org/PathwayBrowser/#/R-DDI-75861 NTP Binds Active Site of RNA Polymerase II IEA Dictyostelium discoideum DDB_G0278843 R-DDI-75862 https://reactome.org/PathwayBrowser/#/R-DDI-75862 Fall Back to Closed Pre-initiation Complex IEA Dictyostelium discoideum DDB_G0278843 R-DDI-75864 https://reactome.org/PathwayBrowser/#/R-DDI-75864 Newly Formed Phosphodiester Bond Stabilized and PPi Released IEA Dictyostelium discoideum DDB_G0278843 R-DDI-75866 https://reactome.org/PathwayBrowser/#/R-DDI-75866 Nucleophillic Attack by 3'-hydroxyl Oxygen of nascent transcript on the Alpha Phosphate of NTP IEA Dictyostelium discoideum DDB_G0278843 R-DDI-75869 https://reactome.org/PathwayBrowser/#/R-DDI-75869 Addition of the fourth nucleotide on the Nascent Transcript: Second Transition IEA Dictyostelium discoideum DDB_G0278843 R-DDI-75873 https://reactome.org/PathwayBrowser/#/R-DDI-75873 Addition of Nucleotides 5 through 9 on the growing Transcript IEA Dictyostelium discoideum DDB_G0278843 R-DDI-75949 https://reactome.org/PathwayBrowser/#/R-DDI-75949 RNA Polymerase II Promoter Opening: First Transition IEA Dictyostelium discoideum DDB_G0278843 R-DDI-9613494 https://reactome.org/PathwayBrowser/#/R-DDI-9613494 Unwinding of DNA for the Nascent Transcript: Second Transition IEA Dictyostelium discoideum DDB_G0278843 R-DDI-9613497 https://reactome.org/PathwayBrowser/#/R-DDI-9613497 Unwinding DNA for the nascent transcript IEA Dictyostelium discoideum DDB_G0278847 R-DDI-1236970 https://reactome.org/PathwayBrowser/#/R-DDI-1236970 Proteasomal clevage of exogenous antigen (26S proteasome catalyst) IEA Dictyostelium discoideum DDB_G0278847 R-DDI-1504193 https://reactome.org/PathwayBrowser/#/R-DDI-1504193 Ubiquitinated DVL is degraded by the proteasome IEA Dictyostelium discoideum DDB_G0278847 R-DDI-174058 https://reactome.org/PathwayBrowser/#/R-DDI-174058 Degradation of multiubiquitinated Cdh1 IEA Dictyostelium discoideum DDB_G0278847 R-DDI-174105 https://reactome.org/PathwayBrowser/#/R-DDI-174105 Degradation of multiubiquitinated cell cycle proteins IEA Dictyostelium discoideum DDB_G0278847 R-DDI-174202 https://reactome.org/PathwayBrowser/#/R-DDI-174202 Degradation of multiubiquitinated Securin IEA Dictyostelium discoideum DDB_G0278847 R-DDI-188191 https://reactome.org/PathwayBrowser/#/R-DDI-188191 APC/C:Cdh1-mediated degradation of Skp2 IEA Dictyostelium discoideum DDB_G0278847 R-DDI-264458 https://reactome.org/PathwayBrowser/#/R-DDI-264458 Proteasome mediated degradation of COP1 IEA Dictyostelium discoideum DDB_G0278847 R-DDI-450466 https://reactome.org/PathwayBrowser/#/R-DDI-450466 AUF1:mRNA complex is destroyed IEA Dictyostelium discoideum DDB_G0278847 R-DDI-5635854 https://reactome.org/PathwayBrowser/#/R-DDI-5635854 GLI2,3 are degraded by the proteasome IEA Dictyostelium discoideum DDB_G0278847 R-DDI-5658430 https://reactome.org/PathwayBrowser/#/R-DDI-5658430 NF1 is degraded by the proteasome IEA Dictyostelium discoideum DDB_G0278847 R-DDI-5665854 https://reactome.org/PathwayBrowser/#/R-DDI-5665854 ADRM1:26S proteaseome binds UCHL5 IEA Dictyostelium discoideum DDB_G0278847 R-DDI-5665871 https://reactome.org/PathwayBrowser/#/R-DDI-5665871 ADRM1 binds 26S proteasome IEA Dictyostelium discoideum DDB_G0278847 R-DDI-5687112 https://reactome.org/PathwayBrowser/#/R-DDI-5687112 MAPK6 is degraded by the 26S proteasome IEA Dictyostelium discoideum DDB_G0278847 R-DDI-5689539 https://reactome.org/PathwayBrowser/#/R-DDI-5689539 ADRM1:26S proteaseome binds USP14 IEA Dictyostelium discoideum DDB_G0278847 R-DDI-68948 https://reactome.org/PathwayBrowser/#/R-DDI-68948 Ubiquitinated Orc1 is degraded by the proteasome IEA Dictyostelium discoideum DDB_G0278847 R-DDI-69016 https://reactome.org/PathwayBrowser/#/R-DDI-69016 Ubiquitinated Cdc6 is degraded by the proteasome IEA Dictyostelium discoideum DDB_G0278847 R-DDI-69600 https://reactome.org/PathwayBrowser/#/R-DDI-69600 Proteolytic degradation of ubiquitinated-Cdc25A IEA Dictyostelium discoideum DDB_G0278847 R-DDI-8850992 https://reactome.org/PathwayBrowser/#/R-DDI-8850992 Proteasome degrades polyubiquitinated PTEN IEA Dictyostelium discoideum DDB_G0278847 R-DDI-8854044 https://reactome.org/PathwayBrowser/#/R-DDI-8854044 Proteasome degrades AURKA ubiquitinated by SCF-FBXL7 IEA Dictyostelium discoideum DDB_G0278847 R-DDI-8866553 https://reactome.org/PathwayBrowser/#/R-DDI-8866553 misfolded CFTR is degraded by the 26S proteasome IEA Dictyostelium discoideum DDB_G0278847 R-DDI-9755306 https://reactome.org/PathwayBrowser/#/R-DDI-9755306 ub UBXN7 is degraded by the 26S proteasome IEA Dictyostelium discoideum DDB_G0278847 R-DDI-983150 https://reactome.org/PathwayBrowser/#/R-DDI-983150 Proteasomal cleavage of substrate IEA Dictyostelium discoideum DDB_G0278847 R-DDI-9907912 https://reactome.org/PathwayBrowser/#/R-DDI-9907912 Formation of the outer ring of the 20S core particle IEA Dictyostelium discoideum DDB_G0278847 R-DDI-9907919 https://reactome.org/PathwayBrowser/#/R-DDI-9907919 Formation of the preholoproteasome IEA Dictyostelium discoideum DDB_G0278847 R-DDI-9907925 https://reactome.org/PathwayBrowser/#/R-DDI-9907925 Formation of the inner ring of the 20S immunoproteasome core particle IEA Dictyostelium discoideum DDB_G0278847 R-DDI-9907928 https://reactome.org/PathwayBrowser/#/R-DDI-9907928 Formation of the inner ring of the 20S thymoproteasome core particle IEA Dictyostelium discoideum DDB_G0278847 R-DDI-9907940 https://reactome.org/PathwayBrowser/#/R-DDI-9907940 Formation of the preholothymoproteasome IEA Dictyostelium discoideum DDB_G0278847 R-DDI-9907941 https://reactome.org/PathwayBrowser/#/R-DDI-9907941 Fromation of the preholoimmunoproteasome IEA Dictyostelium discoideum DDB_G0278847 R-DDI-9908052 https://reactome.org/PathwayBrowser/#/R-DDI-9908052 PSMG1:PSMG2 dimer binds the 20S core particle outer ring IEA Dictyostelium discoideum DDB_G0278847 R-DDI-9908069 https://reactome.org/PathwayBrowser/#/R-DDI-9908069 POMP binds the 20S core particle outer ring IEA Dictyostelium discoideum DDB_G0278847 R-DDI-9908178 https://reactome.org/PathwayBrowser/#/R-DDI-9908178 Formation of the 26S proteasome IEA Dictyostelium discoideum DDB_G0278847 R-DDI-9908709 https://reactome.org/PathwayBrowser/#/R-DDI-9908709 Formation of the PA28-alpha-beta-20S proteasome IEA Dictyostelium discoideum DDB_G0278847 R-DDI-9908721 https://reactome.org/PathwayBrowser/#/R-DDI-9908721 Formation of the PA28gamma-20S proteasome IEA Dictyostelium discoideum DDB_G0278849 R-DDI-169270 https://reactome.org/PathwayBrowser/#/R-DDI-169270 ETFDH oxidises ETF (reduced) to ETF, reduces CoQ to CoQH2 IEA Dictyostelium discoideum DDB_G0278873 R-DDI-6799604 https://reactome.org/PathwayBrowser/#/R-DDI-6799604 GNPDA1,2 hexamers deaminate GlcN6P to Fru(6)P IEA Dictyostelium discoideum DDB_G0278893 R-DDI-1614544 https://reactome.org/PathwayBrowser/#/R-DDI-1614544 Sulfite is oxidized to sulfate IEA Dictyostelium discoideum DDB_G0278897 R-DDI-418582 https://reactome.org/PathwayBrowser/#/R-DDI-418582 G alpha (q) auto-inactivates by hydrolysing GTP to GDP IEA Dictyostelium discoideum DDB_G0278897 R-DDI-8981892 https://reactome.org/PathwayBrowser/#/R-DDI-8981892 Active G alpha (z) binds RGS proteins IEA Dictyostelium discoideum DDB_G0278897 R-DDI-8982012 https://reactome.org/PathwayBrowser/#/R-DDI-8982012 G alpha (i):RGS dissociates to inactive G alpha (i)–i1/i2/i3 IEA Dictyostelium discoideum DDB_G0278897 R-DDI-8982017 https://reactome.org/PathwayBrowser/#/R-DDI-8982017 Active G alpha (q) binds RGS proteins IEA Dictyostelium discoideum DDB_G0278897 R-DDI-8982018 https://reactome.org/PathwayBrowser/#/R-DDI-8982018 G alpha (z):RGS complex dissociates to give inactive G alpha (z) IEA Dictyostelium discoideum DDB_G0278897 R-DDI-8982019 https://reactome.org/PathwayBrowser/#/R-DDI-8982019 Active G alpha (i)–i1/i2/i3 binds RGS proteins IEA Dictyostelium discoideum DDB_G0278897 R-DDI-8982020 https://reactome.org/PathwayBrowser/#/R-DDI-8982020 G alpha (i)–i1/i2/i3 in G (i):RGS complex is inactivated IEA Dictyostelium discoideum DDB_G0278897 R-DDI-8982021 https://reactome.org/PathwayBrowser/#/R-DDI-8982021 G alpha (z) in G alpha (z):RGS complex is inactivated IEA Dictyostelium discoideum DDB_G0278897 R-DDI-8982025 https://reactome.org/PathwayBrowser/#/R-DDI-8982025 G alpha (q) in G (q):RGS complex is inactivated IEA Dictyostelium discoideum DDB_G0278897 R-DDI-8982026 https://reactome.org/PathwayBrowser/#/R-DDI-8982026 G alpha (q):RGS dissociates to inactive G alpha (q) IEA Dictyostelium discoideum DDB_G0278935 R-DDI-5652005 https://reactome.org/PathwayBrowser/#/R-DDI-5652005 RAD18:UBE2B or RBX1:CUL4:DDB1:DTL ubiquitin ligase complex binds PCNA:POLD,POLE:RPA:RFC associated with damaged dsDNA IEA Dictyostelium discoideum DDB_G0278935 R-DDI-5652009 https://reactome.org/PathwayBrowser/#/R-DDI-5652009 RAD18:UBE2B or RBX1:CUL4:DDB1:DTL monoubiquitinates PCNA IEA Dictyostelium discoideum DDB_G0278935 R-DDI-8943003 https://reactome.org/PathwayBrowser/#/R-DDI-8943003 SHPRH polyubiquitinates monoubiquitinated PCNA IEA Dictyostelium discoideum DDB_G0278935 R-DDI-8943007 https://reactome.org/PathwayBrowser/#/R-DDI-8943007 SHPRH binds monoUb-K164-PCNA, RAD6:RAD18, UBE2V2:Ub:UBE2N IEA Dictyostelium discoideum DDB_G0278945 R-DDI-9821475 https://reactome.org/PathwayBrowser/#/R-DDI-9821475 CXXC1 and WDR82 bind SET1A complex IEA Dictyostelium discoideum DDB_G0278945 R-DDI-9821476 https://reactome.org/PathwayBrowser/#/R-DDI-9821476 CXXC1 and WDR82 bind SET1B complex IEA Dictyostelium discoideum DDB_G0278947 R-DDI-1482961 https://reactome.org/PathwayBrowser/#/R-DDI-1482961 CDP-Cho and DAG are converted to PC by CEPT1 at the ER membrane IEA Dictyostelium discoideum DDB_G0278947 R-DDI-1482962 https://reactome.org/PathwayBrowser/#/R-DDI-1482962 CDP-ETA and DAG are converted to PE by CEPT1/EPT1 IEA Dictyostelium discoideum DDB_G0278947 R-DDI-1482973 https://reactome.org/PathwayBrowser/#/R-DDI-1482973 CDP-Cho and DAG are converted to PC by CHPT1 at the Golgi membrane IEA Dictyostelium discoideum DDB_G0278959 R-DDI-156826 https://reactome.org/PathwayBrowser/#/R-DDI-156826 Dissociation of L13a from the 60s ribosomal subunit IEA Dictyostelium discoideum DDB_G0278959 R-DDI-1799332 https://reactome.org/PathwayBrowser/#/R-DDI-1799332 Nascent polypeptide:mRNA:ribosome complex binds signal recognition particle (SRP) IEA Dictyostelium discoideum DDB_G0278959 R-DDI-72671 https://reactome.org/PathwayBrowser/#/R-DDI-72671 eIF5B:GTP is hydrolyzed and released IEA Dictyostelium discoideum DDB_G0278959 R-DDI-72672 https://reactome.org/PathwayBrowser/#/R-DDI-72672 The 60S subunit joins the translation initiation complex IEA Dictyostelium discoideum DDB_G0278959 R-DDI-72673 https://reactome.org/PathwayBrowser/#/R-DDI-72673 Release of 40S and 60S subunits from the 80S ribosome IEA Dictyostelium discoideum DDB_G0278959 R-DDI-927789 https://reactome.org/PathwayBrowser/#/R-DDI-927789 Formation of UPF1:eRF3 complex on mRNA with a premature termination codon and no Exon Junction Complex IEA Dictyostelium discoideum DDB_G0278959 R-DDI-927832 https://reactome.org/PathwayBrowser/#/R-DDI-927832 UPF1 binds an mRNP with a termination codon preceding an Exon Junction Complex IEA Dictyostelium discoideum DDB_G0278959 R-DDI-927889 https://reactome.org/PathwayBrowser/#/R-DDI-927889 SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex) IEA Dictyostelium discoideum DDB_G0278967 R-DDI-156823 https://reactome.org/PathwayBrowser/#/R-DDI-156823 Association of phospho-L13a with GAIT element of Ceruloplasmin mRNA IEA Dictyostelium discoideum DDB_G0278967 R-DDI-5227009 https://reactome.org/PathwayBrowser/#/R-DDI-5227009 ABCF1 binds EIF2 IEA Dictyostelium discoideum DDB_G0278967 R-DDI-72621 https://reactome.org/PathwayBrowser/#/R-DDI-72621 Ribosomal scanning IEA Dictyostelium discoideum DDB_G0278967 R-DDI-72663 https://reactome.org/PathwayBrowser/#/R-DDI-72663 De novo formation of eIF2:GTP IEA Dictyostelium discoideum DDB_G0278967 R-DDI-72669 https://reactome.org/PathwayBrowser/#/R-DDI-72669 Met-tRNAi binds to eIF2:GTP to form the ternary complex IEA Dictyostelium discoideum DDB_G0278967 R-DDI-72670 https://reactome.org/PathwayBrowser/#/R-DDI-72670 Formation of eIF2:GDP:eIF2B intermediate IEA Dictyostelium discoideum DDB_G0278967 R-DDI-72691 https://reactome.org/PathwayBrowser/#/R-DDI-72691 Formation of the 43S pre-initiation complex IEA Dictyostelium discoideum DDB_G0278967 R-DDI-72697 https://reactome.org/PathwayBrowser/#/R-DDI-72697 Start codon recognition IEA Dictyostelium discoideum DDB_G0278967 R-DDI-72722 https://reactome.org/PathwayBrowser/#/R-DDI-72722 eIF2 activation IEA Dictyostelium discoideum DDB_G0278967 R-DDI-9840415 https://reactome.org/PathwayBrowser/#/R-DDI-9840415 DELE1(143-515):EIF2AK1 enhances phosphorylation of EIF2S1 (EIF2alpha) IEA Dictyostelium discoideum DDB_G0278969 R-DDI-6807875 https://reactome.org/PathwayBrowser/#/R-DDI-6807875 ARFGAP, cargo, v-SNAREs and p24 proteins bind nascent COPI complex IEA Dictyostelium discoideum DDB_G0278969 R-DDI-6807877 https://reactome.org/PathwayBrowser/#/R-DDI-6807877 ARFGAPs stimulate ARF GTPase activity IEA Dictyostelium discoideum DDB_G0278969 R-DDI-6809003 https://reactome.org/PathwayBrowser/#/R-DDI-6809003 ERGIC-to-Golgi vesicles bind dynein:dynactin IEA Dictyostelium discoideum DDB_G0278969 R-DDI-6809011 https://reactome.org/PathwayBrowser/#/R-DDI-6809011 cis-Golgi t-SNAREs bind YKT6 on tethered vesicle IEA Dictyostelium discoideum DDB_G0278969 R-DDI-6811417 https://reactome.org/PathwayBrowser/#/R-DDI-6811417 ARFGAP, cargo, vSNARES and p24 proteins bind COPI vesicles at Golgi IEA Dictyostelium discoideum DDB_G0278969 R-DDI-6811418 https://reactome.org/PathwayBrowser/#/R-DDI-6811418 ARFGAPs stimulate ARF GTPase activity at the Golgi membrane IEA Dictyostelium discoideum DDB_G0278969 R-DDI-6811427 https://reactome.org/PathwayBrowser/#/R-DDI-6811427 COPI vesicle uncoating at the ER IEA Dictyostelium discoideum DDB_G0278973 R-DDI-9710959 https://reactome.org/PathwayBrowser/#/R-DDI-9710959 p-STAT1 dimer binds KPNA1 IEA Dictyostelium discoideum DDB_G0278981 R-DDI-1169398 https://reactome.org/PathwayBrowser/#/R-DDI-1169398 ISGylation of host protein filamin B IEA Dictyostelium discoideum DDB_G0278981 R-DDI-1169402 https://reactome.org/PathwayBrowser/#/R-DDI-1169402 ISGylation of E2 conjugating enzymes IEA Dictyostelium discoideum DDB_G0278981 R-DDI-1169403 https://reactome.org/PathwayBrowser/#/R-DDI-1169403 Interaction of E3 ligase with ISG15:E2 complex IEA Dictyostelium discoideum DDB_G0278981 R-DDI-1169406 https://reactome.org/PathwayBrowser/#/R-DDI-1169406 ISGylation of host proteins IEA Dictyostelium discoideum DDB_G0278981 R-DDI-1678842 https://reactome.org/PathwayBrowser/#/R-DDI-1678842 Competitive inhibition of translation initiation by ISGylated 4EHP IEA Dictyostelium discoideum DDB_G0278981 R-DDI-1678843 https://reactome.org/PathwayBrowser/#/R-DDI-1678843 ISGylation of protein translation regulator 4EHP IEA Dictyostelium discoideum DDB_G0278981 R-DDI-5689111 https://reactome.org/PathwayBrowser/#/R-DDI-5689111 PARK2 autoubiquitinates IEA Dictyostelium discoideum DDB_G0278981 R-DDI-9641089 https://reactome.org/PathwayBrowser/#/R-DDI-9641089 Parkin binds Ub:UBE2N:UBE2V1 IEA Dictyostelium discoideum DDB_G0278981 R-DDI-9641096 https://reactome.org/PathwayBrowser/#/R-DDI-9641096 Misfolded proteins bind PRKN:UBE2N:UBE2V1:Ub IEA Dictyostelium discoideum DDB_G0278981 R-DDI-9641109 https://reactome.org/PathwayBrowser/#/R-DDI-9641109 PolyUb:misfolded proteins dissociate from PRKN:UBE2N:UBE2V1 IEA Dictyostelium discoideum DDB_G0278981 R-DDI-9641111 https://reactome.org/PathwayBrowser/#/R-DDI-9641111 Parkin transfers Ub to misfolded proteins IEA Dictyostelium discoideum DDB_G0278981 R-DDI-9641127 https://reactome.org/PathwayBrowser/#/R-DDI-9641127 Ub:misfolded proteins polymerize to PolyUb:misfolded proteins IEA Dictyostelium discoideum DDB_G0278981 R-DDI-9793472 https://reactome.org/PathwayBrowser/#/R-DDI-9793472 RIPK3 binds p-S9-PRKN IEA Dictyostelium discoideum DDB_G0278981 R-DDI-9793485 https://reactome.org/PathwayBrowser/#/R-DDI-9793485 PRKN polyubiquitinates RIPK3 IEA Dictyostelium discoideum DDB_G0278981 R-DDI-983140 https://reactome.org/PathwayBrowser/#/R-DDI-983140 Transfer of Ub from E2 to substrate and release of E2 IEA Dictyostelium discoideum DDB_G0278981 R-DDI-983147 https://reactome.org/PathwayBrowser/#/R-DDI-983147 Release of E3 from polyubiquitinated substrate IEA Dictyostelium discoideum DDB_G0278981 R-DDI-983156 https://reactome.org/PathwayBrowser/#/R-DDI-983156 Polyubiquitination of substrate IEA Dictyostelium discoideum DDB_G0278981 R-DDI-983157 https://reactome.org/PathwayBrowser/#/R-DDI-983157 Interaction of E3 with substrate and E2-Ub complex IEA Dictyostelium discoideum DDB_G0278983 R-DDI-6791222 https://reactome.org/PathwayBrowser/#/R-DDI-6791222 21S pre-rRNA is nucleolytically pr