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Graph Database :: Data Schema

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Entries: RegulationReference
Identifier Name
9855905 Positive gene expression regulation by 'pT153 USF1 dimer:TYR promoter [nucleoplasm]' The Usf-1 transcription factor is a novel target for the stress-responsive p38 kinase and mediates UV-induced Tyrosinase expression
9851042 Positive gene expression regulation by 'pY-STAT3:IRF4 gene [nucleoplasm]' IRF4 Mediates the Oncogenic Effects of STAT3 in Anaplastic Large Cell Lymphomas
9835535 Positive gene expression regulation by 'tcf7l1:ctnnb1:gbx2 gene [nucleoplasm]' The posteriorizing gene Gbx2 is a direct target of Wnt signalling and the earliest factor in neural crest induction
9835815 Positive gene expression regulation by 'tfap2a:pax3 gene [nucleoplasm]' Reiterative AP2a activity controls sequential steps in the neural crest gene regulatory network
9642316 Positive regulation by '2xp-STAT3 [nucleoplasm]' Expression of IL-24, an activator of the JAK1/STAT3/SOCS3 cascade, is enhanced in inflammatory bowel disease
9765929 Positive regulation by '8:IL17RA [extracellular region]' ORF8 contributes to cytokine storm during SARS-CoV-2 infection by activating IL-17 pathway
9641886 Positive regulation by 'ACTIVIN [extracellular region]' Pituitary actions of ligands of the TGF-beta family: activins and inhibins
9641228 Positive regulation by 'ADP [mitochondrial matrix]' Expression, purification and characterization of human glutamate dehydrogenase (GDH) allosteric regulatory mutations
9641624 Positive regulation by 'AGER ligands:AGER [plasma membrane]' Diabetes-associated sustained activation of the transcription factor nuclear factor-kappaB
9642202 Positive regulation by 'AHCYL2 [cytosol]' AHCYL2 (long-IRBIT) as a potential regulator of the electrogenic Na(+)-HCO3(-) cotransporter NBCe1-B
9641435 Positive regulation by 'AMOT proteins [cytosol]' Angiomotin family proteins are novel activators of the LATS2 kinase tumor suppressor
9641983 Positive regulation by 'AMOT proteins [cytosol]' Angiomotin is a novel Hippo pathway component that inhibits YAP oncoprotein
9642708 Positive regulation by 'ANGPTL4 [extracellular region]' Angiopoietin-like protein 4 converts lipoprotein lipase to inactive monomers and modulates lipase activity in adipose tissue
9641804 Positive regulation by 'ANGPTL4 [extracellular region]' Angiopoietin-like protein 4 converts lipoprotein lipase to inactive monomers and modulates lipase activity in adipose tissue
9641359 Positive regulation by 'APP(672-713) [extracellular region]' Calcium signals induced by amyloid beta peptide and their consequences in neurons and astrocytes in culture
9642769 Positive regulation by 'AS160:IRAP [cytoplasmic vesicle membrane]' AS160, the Akt substrate regulating GLUT4 translocation, has a functional Rab GTPase-activating protein domain
9853673 Positive regulation by 'ATP [mitochondrial matrix]' Studies on the regulation of the human E1 subunit of the 2-oxoglutarate dehydrogenase complex, including the identification of a novel calcium-binding site
9641597 Positive regulation by 'ATP2A1-3 [endoplasmic reticulum membrane]' Ca(2+)-ATPase function is required for intracellular trafficking of the Notch receptor in Drosophila
9642209 Positive regulation by 'AcCho [extracellular region]' Biology of incretins: GLP-1 and GIP
9730730 Positive regulation by 'Active ALK dimer [plasma membrane]' Wild-type ALK and activating ALK-R1275Q and ALK-F1174L mutations upregulate Myc and initiate tumor formation in murine neural crest progenitor cells
9642946 Positive regulation by 'As160 [cytoplasmic vesicle membrane]' Rab10, a target of the AS160 Rab GAP, is required for insulin-stimulated translocation of GLUT4 to the adipocyte plasma membrane
9641454 Positive regulation by 'AscH- [nucleoplasm]' Ascorbate induces ten-eleven translocation (Tet) methylcytosine dioxygenase-mediated generation of 5-hydroxymethylcytosine
9641595 Positive regulation by 'AscH- [nucleoplasm]' Ascorbate induces ten-eleven translocation (Tet) methylcytosine dioxygenase-mediated generation of 5-hydroxymethylcytosine
9642141 Positive regulation by 'BBS/CCT complex [cytosol]' BBS6, BBS10, and BBS12 form a complex with CCT/TRiC family chaperonins and mediate BBSome assembly
9641791 Positive regulation by 'BMP2 dimer [extracellular region]' Dlx5 specifically regulates Runx2 type II expression by binding to homeodomain-response elements in the Runx2 distal promoter
9642221 Positive regulation by 'BMP2 dimer [extracellular region]' Runx2-mediated activation of the Bax gene increases osteosarcoma cell sensitivity to apoptosis
9641999 Positive regulation by 'BRCA1 [nucleoplasm]' Brca1 in immunoglobulin gene conversion and somatic hypermutation
9642524 Positive regulation by 'BRCA2 [nucleoplasm]' Stabilization of RAD51 nucleoprotein filaments by the C-terminal region of BRCA2
9642480 Positive regulation by 'BRWD1:AcK9,14-p-S10-histone H3.1 [nucleoplasm]' Histone reader BRWD1 targets and restricts recombination to the Igk locus
9642403 Positive regulation by 'BRWD1:AcK9,14-pS10-histone H3 [nucleoplasm]' Histone reader BRWD1 targets and restricts recombination to the Igk locus
9641346 Positive regulation by 'Bmp2 dimer [extracellular region]' Dlx5 specifically regulates Runx2 type II expression by binding to homeodomain-response elements in the Runx2 distal promoter
9642766 Positive regulation by 'CABLES1 [nucleoplasm]' Cables enhances cdk2 tyrosine 15 phosphorylation by Wee1, inhibits cell growth, and is lost in many human colon and squamous cancers
9641985 Positive regulation by 'CABLES1 [nucleoplasm]' Cables enhances cdk2 tyrosine 15 phosphorylation by Wee1, inhibits cell growth, and is lost in many human colon and squamous cancers
9672332 Positive regulation by 'CABP1 [plasma membrane]' Ca2+-binding proteins tune Ca2+-feedback to Cav1.3 channels in mouse auditory hair cells
9672335 Positive regulation by 'CABP2 [plasma membrane]' Ca2+-binding proteins tune Ca2+-feedback to Cav1.3 channels in mouse auditory hair cells
9641320 Positive regulation by 'CAK [nucleoplasm]' Targeting transcription regulation in cancer with a covalent CDK7 inhibitor
9641254 Positive regulation by 'CD209:ManLAM [plasma membrane]' C-type lectin DC-SIGN modulates Toll-like receptor signaling via Raf-1 kinase-dependent acetylation of transcription factor NF-kappaB
9642922 Positive regulation by 'CEACAM heterodimer [plasma membrane]' GPI-anchored CEA family glycoproteins CEA and CEACAM6 mediate their biological effects through enhanced integrin alpha5beta1-fibronectin interaction
9644098 Positive regulation by 'CEBPA [nucleoplasm]' Autoregulation of the human C/EBP alpha gene by stimulation of upstream stimulatory factor binding
9641601 Positive regulation by 'CEBPA [nucleoplasm]' Phosphorylation of CCAAT/enhancer-binding protein alpha regulates GLUT4 expression and glucose transport in adipocytes
9642850 Positive regulation by 'CISH gene, SOCS1 gene, SOCS2 gene:p-STAT5 dimer [nucleoplasm]' Suppressor of cytokine signaling (SOCS) proteins are induced by IL-7 and target surface CD127 protein for degradation in human CD8 T cells
9641512 Positive regulation by 'CIT [cytosol]' Differential activation of recombinant human acetyl-CoA carboxylases 1 and 2 by citrate
9845034 Positive regulation by 'CLIP1(1-1083)-p-6Y LTK(488-864) fusion dimer [plasma membrane]' The CLIP1-LTK fusion is an oncogenic driverĀ in non-small-cell lung cancer
9641869 Positive regulation by 'Ca-P60A [endoplasmic reticulum membrane]' Ca(2+)-ATPase function is required for intracellular trafficking of the Notch receptor in Drosophila
9641440 Positive regulation by 'Ca2+ [cytosol]' 0121227022 Boyer, PD Phosphorylase kinase The Enzymes 3rd ed
9839185 Positive regulation by 'Ca2+ [cytosol]' Coordinate changes in gene expression which mark the spinous to granular cell transition in epidermis are regulated by protein kinase C
9839205 Positive regulation by 'Ca2+ [cytosol]' Epidermal differentiation: the bare essentials
9727658 Positive regulation by 'Ca2+ [cytosol]' Transcription of the human loricrin gene in vitro is induced by calcium and cell density and suppressed by retinoic acid
9671760 Positive regulation by 'Ca2+ [extracellular region]' Characterization of factor VII association with tissue factor in solution. High and low affinity calcium binding sites in factor VII contribute to functionally distinct interactions
9671030 Positive regulation by 'Ca2+ [extracellular region]' High affinity Ca(2+)-binding site in the serine protease domain of human factor VIIa and its role in tissue factor binding and development of catalytic activity
9641489 Positive regulation by 'Ccnd1:Crebbp:Notch1 Gene [nucleoplasm]' Transcriptional role of cyclin D1 in development revealed by a genetic-proteomic screen
9641868 Positive regulation by 'Cdh1:phospho-APC/C complex [nucleoplasm]' DNA damage signaling triggers degradation of histone methyltransferases through APC/C(Cdh1) in senescent cells
9641444 Positive regulation by 'Cdh1:phospho-APC/C complex [nucleoplasm]' DNA damage signaling triggers degradation of histone methyltransferases through APC/C(Cdh1) in senescent cells
9642977 Positive regulation by 'Cebpa [nucleoplasm]' Sequential gene promoter interactions of C/EBPbeta, C/EBPalpha, and PPARgamma during adipogenesis
9642232 Positive regulation by 'Cebpb [nucleoplasm]' Critical role for Ebf1 and Ebf2 in the adipogenic transcriptional cascade
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