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Entries: FailedReaction
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Identifier Name
R-HSA-5251562 Deletions in the AXIN1 gene prevent expression of AXIN1 protein
R-HSA-5251559 Deletions of the AMER1 gene prevent expression of AMER1 protein
R-HSA-3642203 Dimeric TGFB1 does not bind TGFBR2 MSI frameshift mutants
R-HSA-5638137 EGFRvIII cancer variant does not bind EGF ligand
R-HSA-5637794 EGFRvIII does not bind CBL
R-HSA-9665280 ERBB2 KD mutants do not bind osimertinib
R-HSA-9665315 ERBB2 T733I does not bind tesevatinib
R-HSA-9665311 ERBB2 T798M does not bind afatinib
R-HSA-9665304 ERBB2 T862A does not bind sapitinib
R-HSA-9665708 ERBB2 TMD/JMD mutants do not bind pertuzumab
R-HSA-9670189 F8 variant does not bind the cell membrane
R-HSA-9665809 F8 variant does not bind von Willebrand factor
R-HSA-9666383 F8 variant is not cleaved by thrombin
R-HSA-9661980 F8 variant is not secreted
R-HSA-9668148 F8 variant is not sulfonated at Y1699
R-HSA-9670888 F9 variant is not secreted
R-HSA-2220978 FBXW7 WD mutants do not bind NICD1
R-HSA-9673223 FIX(29-461) variant is not activated (factor XIa catalyst)
R-HSA-9670874 FIXa variant:FVIIIa does not convert FX to the active FXa
R-HSA-9668365 FVIIIa variant:FIXa does not convert FX to the active FXa
R-HSA-9673231 GGCX does not gamma-carboxylate 3D-F9(29-461) (pro-factor IX)
R-HSA-9710468 GSDME variant does not bind PIPs
R-HSA-5483229 HHAT G287V doesn't palmitoylate Hh-Np
R-HSA-5358460 HPE SHH variants don't undergo autoproteolytic cleavage
R-HSA-5602603 IRAK4 deficiency blocks formation of the MyD88-IRAK4 Myddosome in the TLR5 pathway
R-HSA-9669859 Imatinib-resistant KIT mutants do not bind imatinib
R-HSA-9674397 Imatinib-resistant PDGFR mutants don't bind imatinib
R-HSA-1225956 Inefficient ubiquitination of ligand-responsive p-6Y-EGFR mutants by p-Y371-CBL
R-HSA-9702570 KW2449-resistant FLT3 mutants don't bind KW2449
R-HSA-6802837 Loss-of-function NF1 variants don't stimulate RAS GTPase activity
R-HSA-9023461 MECP2 T158A:SIN3A complex does not bind BDNF gene promoter
R-HSA-9005585 MECP2 mutants P302R,K304E,K305R,R306C,(R306H) do not bind NCoR/SMRT complex
R-NUL-9005752 MECP2 mutants P302R,K304E,K305R,R306C,(R306H) do not bind NCoR/Smrt complex
R-HSA-9022465 MECP2 mutants R106W, D121G, R133H, S134F, T158M and T158A do not bind to 5mC-DNA
R-HSA-9022462 MECP2 mutants R133C ,D121G, R133H and S134F do not bind 5hmC-DNA
R-HSA-5545484 MLH1 variants-defective DNA mismatch repair
R-HSA-5577259 MSH2 variant:MSH3-defective DNA mismatch repair
R-HSA-5577244 MSH2 variant:MSH6-defective DNA mismatch repair
R-HSA-5578663 MSH3 variant:MSH2-defective DNA mismatch repair
R-HSA-5632970 MSH6 variant:MSH2-defective DNA mismatch repair
R-HSA-9669863 Masitinib-resistant KIT mutants do not bind masitinib
R-HSA-5339713 Misspliced GSK3beta mutants stabilize beta-catenin levels
R-HSA-9628737 NEIL1 G83D does not cleave DHU
R-HSA-9628756 NEIL1 G83D does not cleave FapyA
R-HSA-9628758 NEIL1 G83D does not cleave FapyG
R-HSA-9629917 NEIL1 Q282TER does not translocate to the nucleus
R-HSA-9629245 NEIL3 D132V does not cleave 5-guanidinohydantoin (Gh)
R-HSA-5228811 NFKBIA variant is not phosphorylated within IkBA:NF-kappaB
R-HSA-2660819 NOTCH1 t(7;9)(NOTCH1:M1580_K2555) does not bind DLL1
R-HSA-2660815 NOTCH1 t(7;9)(NOTCH1:M1580_K2555) does not bind DLL4
R-HSA-2660822 NOTCH1 t(7;9)(NOTCH1:M1580_K2555) does not bind JAG1
R-HSA-2660816 NOTCH1 t(7;9)(NOTCH1:M1580_K2555) does not bind JAG2
R-HSA-9630055 NTHL1 D239Y does not cleave dihydrouracil (DHU)
R-HSA-9630053 NTHL1 D239Y does not cleave thymine glycol (Tg)
R-HSA-9700114 NVP-TAE684-resistant ALK mutants don't bind NVP-TAE684
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