Identifier | Name |
---|---|
9643607 | guanyl-nucleotide exchange factor activity of p-Y31,Y118-PXN:CRK:DOCK180:ELMO1,ELMO2 [cytosol] Brk activates rac1 and promotes cell migration and invasion by phosphorylating paxillin |
9643996 | guanylate kinase activity of GUK1 [cytosol] Cloning, characterization, and modeling of mouse and human guanylate kinases |
9643430 | helicase activity of yMcm2-7 complex [nucleoplasm] Mcm4,6,7 uses a 'pump in ring' mechanism to unwind DNA by steric exclusion and actively translocate along a duplex |
9774585 | heparanase activity of HPSE dimer [lysosomal lumen] Structural recognition by recombinant human heparanase that plays critical roles in tumor metastasis. Hierarchical sulfate groups with different effects and the essential target disulfated trisaccharide sequence |
9643422 | histidine ammonia-lyase activity of HAL [cytosol] Molecular characterization of histidinemia: identification of four missense mutations in the histidase gene |
9643163 | histone acetyltransferase activity of B-WICH:rDNA Promoter:KAT2B:KAT2A:EP300 [nucleoplasm] Nuclear myosin 1c facilitates the chromatin modifications required to activate rRNA gene transcription and cell cycle progression |
9643688 | histone acetyltransferase activity of MSL [nucleoplasm] A human protein complex homologous to the Drosophila MSL complex is responsible for the majority of histone H4 acetylation at lysine 16 |
9643166 | histone acetyltransferase activity of NSL [nucleoplasm] Subunit composition and substrate specificity of a MOF-containing histone acetyltransferase distinct from the male-specific lethal (MSL) complex |
9643514 | histone deacetylase activity of eNoSC [nucleoplasm] Epigenetic control of rDNA loci in response to intracellular energy status |
9643450 | histone demethylase activity (H3-K27 specific) of KDM6B:Fe2+ [nucleoplasm] The histone H3 lysine-27 demethylase Jmjd3 links inflammation to inhibition of polycomb-mediated gene silencing |
9643591 | histone demethylase activity (H3-K27 specific) of MLL2,3 complex [nucleoplasm] A histone H3 lysine 27 demethylase regulates animal posterior development |
9643601 | histone demethylase activity of p-T774-PKN1:AR:Androgen:KLK2,3 Gene:Nucleosome with p-T12, Me3K-10-H3:KDM4C [nucleoplasm] Phosphorylation of histone H3 at threonine 11 establishes a novel chromatin mark for transcriptional regulation |
9643256 | histone demethylase activity of p-T774-PKN1:AR:Androgen:KLK2,KLK3 Gene:Nucleosome with p-T12,Me2K-10-H3:KDM1A [nucleoplasm] Phosphorylation of histone H3 at threonine 11 establishes a novel chromatin mark for transcriptional regulation |
9643706 | histone demethylase activity of p-T774-PKN1:AR:Androgen:KLK2,KLK3 Gene:Nucleosome with p-T12,MeK-10-H3:KDM1A [nucleoplasm] Phosphorylation of histone H3 at threonine 11 establishes a novel chromatin mark for transcriptional regulation |
9643384 | histone methyltransferase activity (H3-K4 specific) of H3K4me2-Nucleosome:GP1BA gene:RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] Histone arginine methylation keeps RUNX1 target genes in an intermediate state |
9643364 | histone methyltransferase activity (H3-K4 specific) of H3K4me2-Nucleosome:ITGA2B gene:RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] Histone arginine methylation keeps RUNX1 target genes in an intermediate state |
9644019 | histone methyltransferase activity (H3-K4 specific) of H3K4me2-Nucleosome:MIR27A gene:RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] Histone arginine methylation keeps RUNX1 target genes in an intermediate state |
9643559 | histone methyltransferase activity (H3-K4 specific) of H3K4me2-Nucleosome:THBS1 gene:RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] Histone arginine methylation keeps RUNX1 target genes in an intermediate state |
9643340 | histone methyltransferase activity (H3-K4 specific) of PRDM9:DNA Complex [nucleoplasm] A histone H3 methyltransferase controls epigenetic events required for meiotic prophase |
9643425 | histone methyltransferase activity (H3-K4 specific) of Prdm9 [nucleoplasm] A histone H3 methyltransferase controls epigenetic events required for meiotic prophase |
9643860 | histone methyltransferase activity (H3-K4 specific) of RUNX1:CBFB:KMT2A:SPI1 gene:Nucleosome [nucleoplasm] The ability of MLL to bind RUNX1 and methylate H3K4 at PU.1 regulatory regions is impaired by MDS/AML-associated RUNX1/AML1 mutations |
9643793 | histone methyltransferase activity (H3-K4 specific) of RUNX1:Cbfb:KMT2A:Spi1 gene:Nucleosome [nucleoplasm] The ability of MLL to bind RUNX1 and methylate H3K4 at PU.1 regulatory regions is impaired by MDS/AML-associated RUNX1/AML1 mutations |
9643592 | histone methyltransferase activity (H3-K9 specific) of Ttf-I:rDNA:CSB:G9a:NuRD [nucleoplasm] Activation of RNA polymerase I transcription by cockayne syndrome group B protein and histone methyltransferase G9a |
9643712 | histone methyltransferase activity (H3-K9 specific) of eNoSC [nucleoplasm] Epigenetic control of rDNA loci in response to intracellular energy status |
9643306 | histone-arginine N-methyltransferase activity of RUNX1:CBFB:SIN3A,(SIN3B):PRMT6:HDAC1:GP1BA gene:H3K4me2-Nucleosome [nucleoplasm] Histone arginine methylation keeps RUNX1 target genes in an intermediate state |
9643720 | histone-arginine N-methyltransferase activity of RUNX1:CBFB:SIN3A,(SIN3B):PRMT6:HDAC1:ITGA2B gene:H3K4me2-Nucleosome [nucleoplasm] Histone arginine methylation keeps RUNX1 target genes in an intermediate state |
9643546 | histone-arginine N-methyltransferase activity of RUNX1:CBFB:SIN3A,(SIN3B):PRMT6:HDAC1:THBS1 gene:H3K4me2-Nucleosome [nucleoplasm] Thrombospondin-1 is a transcriptional repression target of PRMT6 |
9643129 | homogentisate 1,2-dioxygenase activity of HGD hexamer [cytosol] The molecular basis of alkaptonuria |
9731592 | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides of NUDT1 [cytosol] MutT homologue 1 (MTH1) catalyzes the hydrolysis of mutagenic O6-methyl-dGTP |
9731593 | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides of NUDT1 [cytosol] MutT homologue 1 (MTH1) removes N6-methyl-dATP from the dNTP pool |
9731631 | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides of NUDT1 [cytosol] MutT homologue 1 (MTH1) removes N6-methyl-dATP from the dNTP pool |
9673051 | hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides of PM20D1 [extracellular region] The Secreted Enzyme PM20D1 Regulates Lipidated Amino Acid Uncouplers of Mitochondria |
9643304 | hydroxyacid-oxoacid transhydrogenase activity of ADHFE1(1-?) [mitochondrial matrix] Kinetic characterization of human hydroxyacid-oxoacid transhydrogenase: relevance to D-2-hydroxyglutaric and gamma-hydroxybutyric acidurias |
9816292 | hypotaurine dehydrogenase activity of FMO1:FAD [endoplasmic reticulum membrane] Flavin-Containing Monooxygenase 1 Catalyzes the Production of Taurine from Hypotaurine |
9727344 | hypoxanthine dehydrogenase activity of XDH dimer [cytosol] Cloning and expression in vitro of human xanthine dehydrogenase/oxidase |
9643481 | hypoxanthine oxidase activity of XDH dimer [cytosol] Cloning and expression in vitro of human xanthine dehydrogenase/oxidase |
9643920 | inorganic diphosphatase activity of PPA1 dimer [cytosol] Studies on human erythrocyte inorganic pyrophosphatase |
9643663 | inositol bisphosphate phosphatase activity of MTMR7 [cytosol] Characterization of myotubularin-related protein 7 and its binding partner, myotubularin-related protein 9 |
9643754 | inositol bisphosphate phosphatase activity of MTMR7:MTMR9 [cytosol] Characterization of myotubularin-related protein 7 and its binding partner, myotubularin-related protein 9 |
9643779 | inositol bisphosphate phosphatase activity of Mtmr7 [cytosol] Characterization of myotubularin-related protein 7 and its binding partner, myotubularin-related protein 9 |
9643883 | inositol bisphosphate phosphatase activity of Mtmr7:Mtmr9 [cytosol] Characterization of myotubularin-related protein 7 and its binding partner, myotubularin-related protein 9 |
9643463 | inositol tetrakisphosphate 1-kinase activity of ITPK1 [cytosol] Isolation of inositol 1,3,4-trisphosphate 5/6-kinase, cDNA cloning and expression of the recombinant enzyme |
9643063 | inositol-1,3,4-trisphosphate 5-kinase activity of ITPK1 [cytosol] Multitasking in signal transduction by a promiscuous human Ins(3,4,5,6)P(4) 1-kinase/Ins(1,3,4)P(3) 5/6-kinase |
9643914 | inositol-1,3,4-trisphosphate 6-kinase activity of ITPK1 [cytosol] Multitasking in signal transduction by a promiscuous human Ins(3,4,5,6)P(4) 1-kinase/Ins(1,3,4)P(3) 5/6-kinase |
9861285 | iron-sulfur cluster binding activity of ACO1 [cytosol] Crystal structure of human iron regulatory protein 1 as cytosolic aconitase |
9643487 | iron-sulfur transferase activity of NAR1:CIA1:YHR122W:MET18 [cytosol] MMS19 assembles iron-sulfur proteins required for DNA metabolism and genomic integrity |
9643323 | iron-sulfur transferase activity of NARFL:CIAO1:FAM96B:MMS19 [cytosol] MMS19 assembles iron-sulfur proteins required for DNA metabolism and genomic integrity |
9643803 | isocitrate dehydrogenase (NAD+) activity of IDH3 octamer [mitochondrial matrix] Evaluation by mutagenesis of the importance of 3 arginines in alpha, beta, and gamma subunits of human NAD-dependent isocitrate dehydrogenase |
9643496 | isocitrate dehydrogenase (NADP+) activity of IDH1 dimer [cytosol] Cancer-associated IDH1 mutations produce 2-hydroxyglutarate |
9643511 | isocitrate dehydrogenase (NADP+) activity of IDH1 dimer [peroxisomal matrix] Cancer-associated IDH1 mutations produce 2-hydroxyglutarate |
9643209 | isocitrate dehydrogenase (NADP+) activity of IDH2 dimer [mitochondrial matrix] Insights from retinitis pigmentosa into the roles of isocitrate dehydrogenases in the Krebs cycle |
9644049 | isovaleryl-CoA dehydrogenase activity of IVD tetramer [mitochondrial matrix] Purification and properties of short chain acyl-CoA, medium chain acyl-CoA, and isovaleryl-CoA dehydrogenases from human liver |
9643327 | ketohexokinase activity of KHK dimer [cytosol] Properties of normal and mutant recombinant human ketohexokinases and implications for the pathogenesis of essential fructosuria |
9643870 | kynurenine-oxoglutarate transaminase activity of PXLP-KYAT1 dimer [cytosol] Purification and characterization of kynurenine aminotransferase I from human brain |
9643805 | lactate transmembrane transporter activity of BSG:MCTs [plasma membrane] Basigin (CD147) is the target for organomercurial inhibition of monocarboxylate transporter isoforms 1 and 4: the ancillary protein for the insensitive MCT2 is EMBIGIN (gp70) |
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