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Entries: ControlReference
Identifier Name
9643405 MAP kinase kinase kinase activity of p-S400,T290-MAP3K8 [cytosol] Activation of MEK-1 and SEK-1 by Tpl-2 proto-oncoprotein, a novel MAP kinase kinase kinase
9818832 Met1-linked polyubiquitin deubiquitinase activity of TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD [plasma membrane] CYLD Limits Lys63- and Met1-Linked Ubiquitin at Receptor Complexes to Regulate Innate Immune Signaling
9643479 N(6)-L-threonylcarbamoyladenine synthase activity of EKC complex [nucleoplasm] Functional assignment of KEOPS/EKC complex subunits in the biosynthesis of the universal t6A tRNA modification
9643170 N-acetylmuramoyl-L-alanine amidase activity of PGLYRP2 dimer [extracellular region] Human peptidoglycan recognition protein-L is an N-acetylmuramoyl-L-alanine amidase
9643084 N-acetyltransferase activity of NAT10:THUMPD1 [nucleoplasm] Human NAT10 is an ATP-dependent RNA acetyltransferase responsible for N4-acetylcytidine formation in 18 S ribosomal RNA (rRNA)
9643765 N6-mAMP deaminase activity of ADAL:Zn [cytosol] Adenosine deaminase-like protein 1 (ADAL1): characterization and substrate specificity in the hydrolysis of N(6)- or O(6)-substituted purine or 2-aminopurine nucleoside monophosphates
9643474 N6-threonylcarbomyladenosine methylthiotransferase activity of CDKAL1:4Fe-4S [endoplasmic reticulum membrane] Identification of eukaryotic and prokaryotic methylthiotransferase for biosynthesis of 2-methylthio-N6-threonylcarbamoyladenosine in tRNA
9643087 NAD(P)+ transhydrogenase activity of NNT dimer [mitochondrial inner membrane] The high-resolution structure of the NADP(H)-binding component (dIII) of proton-translocating transhydrogenase from human heart mitochondria
9643185 NAD+ nucleosidase activity of BST1 dimer [plasma membrane] Crystallographic studies on human BST-1/CD157 with ADP-ribosyl cyclase and NAD glycohydrolase activities
9644061 NAD+-diphthamide ADP-ribosyltransferase activity of DT(33-225) [cytosol] Adenosine diphosphate ribosylation of aminoacyl transferase II and inhibition of protein synthesis by diphtheria toxin
9643781 NAD-dependent protein deacetylase activity of Sirt1 [nucleoplasm] Acetylation of TAF(I)68, a subunit of TIF-IB/SL1, activates RNA polymerase I transcription.
9644083 NADPH:quinone reductase activity of TP53I3 Dimer [cytosol] Three-dimensional structure and enzymatic function of proapoptotic human p53-inducible quinone oxidoreductase PIG3
9725583 NUMB [plasma membrane] Numb Expression Contributes to the Maintenance of an Undifferentiated State in Human Epidermis
9642964 Negative gene expression regulation by '(p-S451-RUNX2:CBFB,RUNX2:CBFB,RUNX2:HDAC6):CDKN1A gene [nucleoplasm]' Glucose-activated RUNX2 phosphorylation promotes endothelial cell proliferation and an angiogenic phenotype
9641570 Negative gene expression regulation by '2x(p-STAT5A,p-STAT5B):BRWD1 gene [nucleoplasm]' Histone reader BRWD1 targets and restricts recombination to the Igk locus
9657840 Negative gene expression regulation by 'ABCA1 mRNA:miR-144 RISC [cytosol]' MicroRNA-144 regulates hepatic ATP binding cassette transporter A1 and plasma high-density lipoprotein after activation of the nuclear receptor farnesoid X receptor
9641820 Negative gene expression regulation by 'ABCA1 mRNA:miR-26 RISC [cytosol]' MiR-26 controls LXR-dependent cholesterol efflux by targeting ABCA1 and ARL7
9641516 Negative gene expression regulation by 'ABCA1 mRNA:miR-33 RISC [cytosol]' MiR-33 contributes to the regulation of cholesterol homeostasis
9858298 Negative gene expression regulation by 'AXL3:MITF gene [nucleoplasm]' Developmental mechanisms of stripe patterns in rodents
9858291 Negative gene expression regulation by 'AXL3:MITF gene [nucleoplasm]' Melanoma cell invasiveness is regulated by miR-211 suppression of the BRN2 transcription factor
9707518 Negative gene expression regulation by 'BACH1:MAFK [nucleoplasm]' Bach1 functions as a hypoxia-inducible repressor for the heme oxygenase-1 gene in human cells
9641613 Negative gene expression regulation by 'CREM:PER1 gene [nucleoplasm]' Inducible cAMP early repressor regulates the Period 1 gene of the hepatic and adrenal clocks
9641730 Negative gene expression regulation by 'CRHR2:UCN(83-122) [plasma membrane]' Urocortin 1 reduces food intake and ghrelin secretion via CRF(2) receptors
9851010 Negative gene expression regulation by 'DNMT1 [nucleoplasm]' NPM-ALK oncogenic tyrosine kinase controls T-cell identity by transcriptional regulation and epigenetic silencing in lymphoma cells
9850959 Negative gene expression regulation by 'DNMT1:AcK685-p-Y705, S727 STAT3 dimer:IL2RG gene [nucleoplasm]' IL-2R common gamma-chain is epigenetically silenced by nucleophosphin-anaplastic lymphoma kinase (NPM-ALK) and acts as a tumor suppressor by targeting NPM-ALK
9642802 Negative gene expression regulation by 'DREAM complex:CDC25A gene [nucleoplasm]' Evolutionarily conserved multisubunit RBL2/p130 and E2F4 protein complex represses human cell cycle-dependent genes in quiescence
9641835 Negative gene expression regulation by 'DREAM complex:CDC6 gene [nucleoplasm]' Evolutionarily conserved multisubunit RBL2/p130 and E2F4 protein complex represses human cell cycle-dependent genes in quiescence
9642011 Negative gene expression regulation by 'DREAM complex:E2F1 gene [nucleoplasm]' Evolutionarily conserved multisubunit RBL2/p130 and E2F4 protein complex represses human cell cycle-dependent genes in quiescence
9642359 Negative gene expression regulation by 'DREAM complex:PCNA gene [nucleoplasm]' Evolutionarily conserved multisubunit RBL2/p130 and E2F4 protein complex represses human cell cycle-dependent genes in quiescence
9641974 Negative gene expression regulation by 'DREAM complex:RBL1 gene [nucleoplasm]' Evolutionarily conserved multisubunit RBL2/p130 and E2F4 protein complex represses human cell cycle-dependent genes in quiescence
9642902 Negative gene expression regulation by 'DREAM complex:TOP2A gene [nucleoplasm]' Evolutionarily conserved multisubunit RBL2/p130 and E2F4 protein complex represses human cell cycle-dependent genes in quiescence
9641265 Negative gene expression regulation by 'E2F6:(TFDP1,TFDP2):APAF1 gene [nucleoplasm]' E2F-6 suppresses growth-associated apoptosis of human hematopoietic progenitor cells by counteracting proapoptotic activity of E2F-1
9643017 Negative gene expression regulation by 'E2F6:(TFDP1,TFDP2):BRCA1 gene [nucleoplasm]' E2F6 negatively regulates BRCA1 in human cancer cells without methylation of histone H3 on lysine 9
9642627 Negative gene expression regulation by 'E2F6:(TFDP1,TFDP2):CBX5 gene [nucleoplasm]' E2F6 negatively regulates BRCA1 in human cancer cells without methylation of histone H3 on lysine 9
9642014 Negative gene expression regulation by 'E2F6:(TFDP1,TFDP2):RAD51 gene [nucleoplasm]' Chk1 inhibits E2F6 repressor function in response to replication stress to maintain cell-cycle transcription
9641954 Negative gene expression regulation by 'E2F6:(TFDP1,TFDP2):RBBP4 gene [nucleoplasm]' E2F6 negatively regulates BRCA1 in human cancer cells without methylation of histone H3 on lysine 9
9641693 Negative gene expression regulation by 'E2F6:(TFDP1.TFDP2):RBBP8 gene [nucleoplasm]' E2F6 negatively regulates BRCA1 in human cancer cells without methylation of histone H3 on lysine 9
9642139 Negative gene expression regulation by 'E2F6:TFDP1/2,(E2F6:TFDP1:MGA:MAX:EHMT1:EHMT2:CBX3:PRC1.6) [nucleoplasm]' A complex with chromatin modifiers that occupies E2F- and Myc-responsive genes in G0 cells
9641666 Negative gene expression regulation by 'E2F7,E2F8 dimers:E2F1 Gene [nucleoplasm]' E2F7, a novel target, is up-regulated by p53 and mediates DNA damage-dependent transcriptional repression
9642932 Negative gene expression regulation by 'EGR2 [nucleoplasm]' PIASxbeta acts as an activator of Hoxb1 and is antagonized by Krox20 during hindbrain segmentation
9642410 Negative gene expression regulation by 'EP400:p-S15-TP53 Tetramer:CDKN1A Gene [nucleoplasm]' The p400 E1A-associated protein is a novel component of the p53 --> p21 senescence pathway
9642854 Negative gene expression regulation by 'ERBB4s80:TAB2:NCOR1:GFAP gene [nucleoplasm]' Presenilin-dependent ErbB4 nuclear signaling regulates the timing of astrogenesis in the developing brain
9641839 Negative gene expression regulation by 'ERBB4s80:TAB2:NCOR1:S100B gene [nucleoplasm]' Presenilin-dependent ErbB4 nuclear signaling regulates the timing of astrogenesis in the developing brain
9642650 Negative gene expression regulation by 'ERF:ETS2 Gene [nucleoplasm]' ERF: an ETS domain protein with strong transcriptional repressor activity, can suppress ets-associated tumorigenesis and is regulated by phosphorylation during cell cycle and mitogenic stimulation
9641582 Negative gene expression regulation by 'ESR1:estrogen:AXIN1 gene [nucleoplasm]' RUNX1 prevents oestrogen-mediated AXIN1 suppression and β-catenin activation in ER-positive breast cancer
9643014 Negative gene expression regulation by 'ESRRA:PPARG1CB:RUNX2 gene [nucleoplasm]' Estrogen Receptor α (ERα) and Estrogen Related Receptor α (ERRα) are both transcriptional regulators of the Runx2-I isoform
9831024 Negative gene expression regulation by 'Foxc1 [nucleoplasm]' Murine forkhead/winged helix genes Foxc1 (Mf1) and Foxc2 (Mfh1) are required for the early organogenesis of the kidney and urinary tract
9792548 Negative gene expression regulation by 'Foxc1 [nucleoplasm]' The forkhead genes, Foxc1 and Foxc2, regulate paraxial versus intermediate mesoderm cell fate
9831032 Negative gene expression regulation by 'Foxc2 [nucleoplasm]' Murine forkhead/winged helix genes Foxc1 (Mf1) and Foxc2 (Mfh1) are required for the early organogenesis of the kidney and urinary tract
9792552 Negative gene expression regulation by 'Foxc2 [nucleoplasm]' The forkhead genes, Foxc1 and Foxc2, regulate paraxial versus intermediate mesoderm cell fate
9833053 Negative gene expression regulation by 'Gbx2:Otx2 gene [nucleoplasm]' A role for Gbx2 in repression of Otx2 and positioning the mid/hindbrain organizer
9642206 Negative gene expression regulation by 'Glucocorticoid ligand:NR3C1:RUNX2 gene [nucleoplasm]' Down-regulation of type I Runx2 mediated by dexamethasone is required for 3T3-L1 adipogenesis
9642954 Negative gene expression regulation by 'HDAC1:RBL2:E2F4,E2F5:TFDP1,TFDP2; HDAC1:RBL1:E2F4:TFDP1,TFDP2:CCNA2 gene [nucleoplasm]' E2F mediates cell cycle-dependent transcriptional repression in vivo by recruitment of an HDAC1/mSin3B corepressor complex
9641640 Negative gene expression regulation by 'HDAC1:RBL2:E2F4,E2F5:TFDP1,TFDP2; HDAC1:RBL1:E2F4:TFDP1,TFDP2:CDK1 gene [nucleoplasm]' E2F mediates cell cycle-dependent transcriptional repression in vivo by recruitment of an HDAC1/mSin3B corepressor complex
9641575 Negative gene expression regulation by 'HDAC1:RBL2:E2F4,E2F5:TFDP1,TFDP2; HDAC1:RBL1:E2F4:TFDP1,TFDP2:E2F1 gene [nucleoplasm]' E2F mediates cell cycle-dependent transcriptional repression in vivo by recruitment of an HDAC1/mSin3B corepressor complex
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