Identifier | Name |
---|---|
9643416 | GTPase activity of GGC-Rala:GTP [cytoplasmic vesicle membrane] A Ral GAP complex links PI 3-kinase/Akt signaling to RalA activation in insulin action |
9643900 | GTPase activity of RAB33:GTP [Golgi membrane] OATL1, a novel autophagosome-resident Rab33B-GAP, regulates autophagosomal maturation |
9643725 | GTPase activity of RAB35:GTP [clathrin-coated endocytic vesicle membrane] Rab35 regulates an endocytic recycling pathway essential for the terminal steps of cytokinesis |
9643259 | GTPase activity of RAB7A:GTP [lysosomal membrane] The rab7 GTPase resides on a vesicular compartment connected to lysosomes |
9643804 | GTPase activity of p-Y1105-ARHGAP35:RHOA:GTP [cytosol] Breast tumor kinase phosphorylates p190RhoGAP to regulate rho and ras and promote breast carcinoma growth, migration, and invasion |
9820691 | HC-ABCG2 [plasma membrane] Breast cancer resistance protein identifies clonogenic keratinocytes in human interfollicular epidermis |
9728013 | HOPX [nucleoplasm] Homeodomain-only protein HOP is a novel modulator of late differentiation in keratinocytes |
9643590 | IDP phosphatase activity of NUDT16 dimer [nucleoplasm] NUDT16 is a (deoxy)inosine diphosphatase, and its deficiency induces accumulation of single-strand breaks in nuclear DNA and growth arrest |
9643517 | IMP dehydrogenase activity of IMPDH tetramers [cytosol] Recombinant human inosine monophosphate dehydrogenase type I and type II proteins. Purification and characterization of inhibitor binding |
9643305 | ISG15-specific peptidase activity of USP18 [cytosol] UBP43 (USP18) specifically removes ISG15 from conjugated proteins |
9731954 | ITGA6(24-1130) [plasma membrane] Identification and isolation of candidate human keratinocyte stem cells based on cell surface phenotype |
9725614 | ITGB1 [plasma membrane] Enrichment and identification of human 'fetal' epidermal stem cells |
9731950 | ITGB4 [plasma membrane] Single-cell expression profiling of human epidermal stem and transit-amplifying cells: Lrig1 is a regulator of stem cell quiescence |
9643791 | ITP diphosphatase activity of ITPA dimer [cytosol] Cloning, expression, and characterization of a human inosine triphosphate pyrophosphatase encoded by the itpa gene |
9728022 | KLK5 [cytosol] Kallikrein-related peptidase 5 functions in proteolytic processing of profilaggrin in cultured human keratinocytes |
9728087 | KLK5 [cytosol] Selective Substrates and Inhibitors for Kallikrein-Related Peptidase 7 (KLK7) Shed Light on KLK Proteolytic Activity in the Stratum Corneum |
9728084 | KLK7 [cytosol] Keratinocyte-specific mesotrypsin contributes to the desquamation process via kallikrein activation and LEKTI degradation |
9728025 | KLK7 [cytosol] LEKTI is localized in lamellar granules, separated from KLK5 and KLK7, and is secreted in the extracellular spaces of the superficial stratum granulosum |
9727377 | KRT1 [cytosol] Epidermal differentiation: the bare essentials |
9727378 | KRT10 [cytosol] Expression of keratin 1, keratin 10, desmoglein 1 and desmocollin 1 in the epidermis: possible downregulation by interleukin-4 and interleukin-13 in atopic dermatitis |
9725565 | KRT19 [cytosol] The type I keratin 19 possesses distinct and context-dependent assembly properties |
9727409 | KRT24 [cytosol] Role of keratin 24 in human epidermal keratinocytes |
9725597 | KRT78 [cytosol] Localisation of keratin K78 in the basal layer and first suprabasal layers of stratified epithelia completes expression catalogue of type II keratins and provides new insights into sequential keratin expression |
9643950 | L-alanine:2-oxoglutarate aminotransferase activity of GPT dimer [cytosol] cDNA cloning, genomic structure, chromosomal mapping, and functional expression of a novel human alanine aminotransferase |
9643767 | L-alanine:2-oxoglutarate aminotransferase activity of GPT2 dimer [mitochondrial matrix] cDNA cloning, genomic structure, chromosomal mapping, and functional expression of a novel human alanine aminotransferase |
9643913 | L-amino-acid oxidase activity of IL4I1:FAD [extracellular region] Human IL4I1 is a secreted L-phenylalanine oxidase expressed by mature dendritic cells that inhibits T-lymphocyte proliferation |
9643397 | L-aminoadipate-semialdehyde dehydrogenase activity of ALDH7A1 tetramer [mitochondrial matrix] Mutations in antiquitin in individuals with pyridoxine-dependent seizures |
9643893 | L-aspartate:2-oxoglutarate aminotransferase activity of GOT2 dimer [mitochondrial matrix] Bi-allelic GOT2 Mutations Cause a Treatable Malate-Aspartate Shuttle-Related Encephalopathy |
9643270 | L-glucuronate reductase activity of AKR1A1 [cytosol] Mechanism of human aldehyde reductase: characterization of the active site pocket |
9643934 | L-glutamine:pyruvate aminotransferase activity of PXLP-KYAT1 dimer [cytosol] Purification and characterization of kynurenine aminotransferase I from human brain |
9643799 | L-gulonate 3-dehydrogenase activity of CRYL1 dimer [cytosol] Structural and functional characterization of rabbit and human L-gulonate 3-dehydrogenase |
9643825 | L-iditol 2-dehydrogenase activity of SORD tetramer [cytosol] Polyol-pathway enzymes of human brain. Partial purification and properties of sorbitol dehydrogenase |
9643670 | L-lactate dehydrogenase activity of LDH tetramer [cytosol] Properties of human testis-specific lactate dehydrogenase expressed from Escherichia coli |
9815320 | L-malate dehydrogenase activity of MDH1 dimer [cytosol] Biochemical and genetic identity of alpha-keto acid reductase and cytoplasmic malate dehydrogenase from human erythrocytes |
9643763 | L-malate dehydrogenase activity of MDH2 dimer [mitochondrial matrix] An NADH-tetrazolium-coupled sensitive assay for malate dehydrogenase in mitochondria and crude tissue homogenates |
9643582 | L-ornithine transmembrane transporter activity of Mitochondrial ornithine transporters [mitochondrial inner membrane] The mitochondrial ornithine transporter. Bacterial expression, reconstitution, functional characterization, and tissue distribution of two human isoforms |
9643905 | L-phenylalanine:pyruvate aminotransferase activity of PXLP-KYAT1 dimer [cytosol] Purification and characterization of kynurenine aminotransferase I from human brain |
9643585 | L-proline transmembrane transporter activity of SLC36A4 [plasma membrane] SLC36A4 (hPAT4) is a high affinity amino acid transporter when expressed in Xenopus laevis oocytes |
9643289 | L-tryptophan transmembrane transporter activity of SLC36A4 [plasma membrane] SLC36A4 (hPAT4) is a high affinity amino acid transporter when expressed in Xenopus laevis oocytes |
9643179 | L-xylulose reductase (NADP+) activity of DCXR tetramer [plasma membrane] Molecular characterization of mammalian dicarbonyl/L-xylulose reductase and its localization in kidney |
9861125 | LGALS7 [cytosol] Galectin-7, a human 14-kDa S-lectin, specifically expressed in keratinocytes and sensitive to retinoic acid |
9731159 | LRIG1 [plasma membrane] Single-cell expression profiling of human epidermal stem and transit-amplifying cells: Lrig1 is a regulator of stem cell quiescence |
9731943 | LRIG1 mRNA [cytosol] Single-cell expression profiling of human epidermal stem and transit-amplifying cells: Lrig1 is a regulator of stem cell quiescence |
9861247 | LY6D mRNA [cytosol] Transcriptional profiling of epidermal keratinocytes: comparison of genes expressed in skin, cultured keratinocytes, and reconstituted epidermis, using large DNA microarrays |
9711059 | Lys48-specific deubiquitinase activity of RTC [double membrane vesicle viral factory outer membrane] Recognition of Lys48-Linked Di-ubiquitin and Deubiquitinating Activities of the SARS Coronavirus Papain-like Protease |
9711003 | Lys63-specific deubiquitinase activity of N-glycan pp1a-nsp3 [endoplasmic reticulum membrane] SARS coronavirus papain-like protease inhibits the type I interferon signaling pathway through interaction with the STING-TRAF3-TBK1 complex |
9643737 | Lys63-specific deubiquitinase activity of OTUD5 [cytosol] DUBA: a deubiquitinase that regulates type I interferon production |
9685212 | Lys63-specific deubiquitinase activity of RTC [double membrane vesicle viral factory outer membrane] SARS Coronavirus Papain-Like Protease Inhibits the TLR7 Signaling Pathway through Removing Lys63-Linked Polyubiquitination of TRAF3 and TRAF6 |
9818966 | Lys63-specific deubiquitinase activity of TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD [plasma membrane] CYLD Limits Lys63- and Met1-Linked Ubiquitin at Receptor Complexes to Regulate Innate Immune Signaling |
9643552 | Lys63-specific deubiquitinase activity of TNFAIP3 [cytosol] Zinc-finger protein A20, a regulator of inflammation and cell survival, has de-ubiquitinating activity |
9750947 | Lys63-specific deubiquitinase activity of USP14 [cytosol] Reversible ubiquitination shapes NLRC5 function and modulates NF-κB activation switch |
9643366 | MAP kinase kinase activity of Mekk1 [cytosol] Regulation of the activity of MEK kinase 1 (MEKK1) by autophosphorylation within the kinase activation domain |
9643515 | MAP kinase kinase kinase activity of MAP3K1 [cytosol] Regulation of the activity of MEK kinase 1 (MEKK1) by autophosphorylation within the kinase activation domain |
9644066 | MAP kinase kinase kinase activity of TAK1 complex [cytosol] TAK1 is a ubiquitin-dependent kinase of MKK and IKK |
9643180 | MAP kinase kinase kinase activity of Tpl2 [cytosol] Activation of MEK-1 and SEK-1 by Tpl-2 proto-oncoprotein, a novel MAP kinase kinase kinase |
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