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Entries: CatalystActivityReference
Identifier Name
9643620 ATPase-coupled transmembrane transporter activity of Abcb1a [plasma membrane] P-glycoprotein-mediated active efflux of the anti-HIV1 nucleoside abacavir limits cellular accumulation and brain distribution
9643386 ATPase-coupled transmembrane transporter activity of Abcg2 dimer [plasma membrane] Abcg2/Bcrp1 mediates the polarized transport of antiretroviral nucleosides abacavir and zidovudine
9643764 C-5 sterol desaturase activity of SC5D [endoplasmic reticulum membrane] Lathosterolosis, a novel multiple-malformation/mental retardation syndrome due to deficiency of 3beta-hydroxysteroid-delta5-desaturase
9643175 CTP synthase activity of CTPS tetramer [cytosol] Expression of Human CTP synthetase in Saccharomyces cerevisiae reveals phosphorylation by protein kinase A
9643873 CTP synthase activity of CTPS2 tetramer [cytosol] Identification of a cDNA encoding an isoform of human CTP synthetase
9643124 D-aspartate oxidase activity of DDO:FAD [peroxisomal matrix] Characterization of the enzymatic and structural properties of human D-aspartate oxidase and comparison with those of the rat and mouse enzymes
9643945 D-glucose transmembrane transporter activity of GLUT1 / SLC2A1 tetramer [plasma membrane] Structural analysis of the GLUT1 facilitative glucose transporter (review).
9643960 D-glucose transmembrane transporter activity of GLUT2 / SLC2A2 tetramer [plasma membrane] Kinetic analysis of the liver-type (GLUT2) and brain-type (GLUT3) glucose transporters in Xenopus oocytes: substrate specificities and effects of transport inhibitors
9643766 D-glucose transmembrane transporter activity of GLUT3 / SLC2A3 tetramer [plasma membrane] Kinetic analysis of the liver-type (GLUT2) and brain-type (GLUT3) glucose transporters in Xenopus oocytes: substrate specificities and effects of transport inhibitors
9643789 D-xylulose reductase activity of SORD tetramer [cytosol] Membrane-bound sorbitol dehydrogenase in human red blood cells. Studies in normal subjects and in enzyme-deficient subjects with congenital cataracts
9857478 DNA-binding transcription activator activity, RNA polymerase II-specific of MLXIPL:MLX [nucleoplasm] Direct role of ChREBP.Mlx in regulating hepatic glucose-responsive genes.
9857001 DNA-binding transcription factor activity of MLX [nucleoplasm] Mlx, a new Max-like bHLHZip family member: the center stage of a novel transcription factors regulatory pathway?
9643218 DNA-directed 5'-3' RNA polymerase activity of RNA Polymerase I Holoenzyme [nucleoplasm] Intergenic transcripts regulate the epigenetic state of rRNA genes
9860664 G protein-coupled acetylcholine receptor activity of CHRM3 [plasma membrane] A critical role for beta cell M3 muscarinic acetylcholine receptors in regulating insulin release and blood glucose homeostasis in vivo
9643147 GMP reductase activity of GMPR tetramers [cytosol] Reaction mechanism and specificity of human GMP reductase. Substrates, inhibitors, activators, and inactivators
9643930 GMP synthase (glutamine-hydrolyzing) activity of GMPS [cytosol] Biochemical characterization of human GMP synthetase
9643075 GTPase activator activity of Rap1 GTPase-activating proteins [cytosol] Multiple roles of Rap1 in hematopoietic cells: complementary versus antagonistic functions
9643192 GTPase activator activity of p-EPHBs:EFNBs:RASA1:HRAS:GTP [plasma membrane] Regulation of the Ras signaling pathway by GTPase-activating protein in PC12 cells
9643107 GTPase activity of 28S ribosomal subunit:MTIF3:MTIF2:GTP:mRNA:fMet-tRNA(fMet) [mitochondrial inner membrane] A single mammalian mitochondrial translation initiation factor functionally replaces two bacterial factors
9644062 GTPase activity of 55S ribosome:MRRF:GFM2:GTP [mitochondrial inner membrane] EF-G2mt is an exclusive recycling factor in mammalian mitochondrial protein synthesis
9643210 GTPase activity of 55S ribosome:mRNA:tRNA:peptidyl-tRNA:GFM1:GTP [mitochondrial inner membrane] EF-G2mt is an exclusive recycling factor in mammalian mitochondrial protein synthesis
9643365 GTPase activity of GGC-RAB8A,10,13,14:GTP [cytoplasmic vesicle membrane] AS160, the Akt substrate regulating GLUT4 translocation, has a functional Rab GTPase-activating protein domain
9643416 GTPase activity of GGC-Rala:GTP [cytoplasmic vesicle membrane] A Ral GAP complex links PI 3-kinase/Akt signaling to RalA activation in insulin action
9643900 GTPase activity of RAB33:GTP [Golgi membrane] OATL1, a novel autophagosome-resident Rab33B-GAP, regulates autophagosomal maturation
9643725 GTPase activity of RAB35:GTP [clathrin-coated endocytic vesicle membrane] Rab35 regulates an endocytic recycling pathway essential for the terminal steps of cytokinesis
9643259 GTPase activity of RAB7A:GTP [lysosomal membrane] The rab7 GTPase resides on a vesicular compartment connected to lysosomes
9643804 GTPase activity of p-Y1105-ARHGAP35:RHOA:GTP [cytosol] Breast tumor kinase phosphorylates p190RhoGAP to regulate rho and ras and promote breast carcinoma growth, migration, and invasion
9643590 IDP phosphatase activity of NUDT16 dimer [nucleoplasm] NUDT16 is a (deoxy)inosine diphosphatase, and its deficiency induces accumulation of single-strand breaks in nuclear DNA and growth arrest
9643517 IMP dehydrogenase activity of IMPDH tetramers [cytosol] Recombinant human inosine monophosphate dehydrogenase type I and type II proteins. Purification and characterization of inhibitor binding
9643305 ISG15-specific peptidase activity of USP18 [cytosol] UBP43 (USP18) specifically removes ISG15 from conjugated proteins
9643791 ITP diphosphatase activity of ITPA dimer [cytosol] Cloning, expression, and characterization of a human inosine triphosphate pyrophosphatase encoded by the itpa gene
9643950 L-alanine:2-oxoglutarate aminotransferase activity of GPT dimer [cytosol] cDNA cloning, genomic structure, chromosomal mapping, and functional expression of a novel human alanine aminotransferase
9643767 L-alanine:2-oxoglutarate aminotransferase activity of GPT2 dimer [mitochondrial matrix] cDNA cloning, genomic structure, chromosomal mapping, and functional expression of a novel human alanine aminotransferase
9643913 L-amino-acid oxidase activity of IL4I1:FAD [extracellular region] Human IL4I1 is a secreted L-phenylalanine oxidase expressed by mature dendritic cells that inhibits T-lymphocyte proliferation
9643397 L-aminoadipate-semialdehyde dehydrogenase activity of ALDH7A1 tetramer [mitochondrial matrix] Mutations in antiquitin in individuals with pyridoxine-dependent seizures
9643893 L-aspartate:2-oxoglutarate aminotransferase activity of GOT2 dimer [mitochondrial matrix] Bi-allelic GOT2 Mutations Cause a Treatable Malate-Aspartate Shuttle-Related Encephalopathy
9643270 L-glucuronate reductase activity of AKR1A1 [cytosol] Mechanism of human aldehyde reductase: characterization of the active site pocket
9643934 L-glutamine:pyruvate aminotransferase activity of PXLP-KYAT1 dimer [cytosol] Purification and characterization of kynurenine aminotransferase I from human brain
9643799 L-gulonate 3-dehydrogenase activity of CRYL1 dimer [cytosol] Structural and functional characterization of rabbit and human L-gulonate 3-dehydrogenase
9643825 L-iditol 2-dehydrogenase activity of SORD tetramer [cytosol] Polyol-pathway enzymes of human brain. Partial purification and properties of sorbitol dehydrogenase
9643670 L-lactate dehydrogenase activity of LDH tetramer [cytosol] Properties of human testis-specific lactate dehydrogenase expressed from Escherichia coli
9815320 L-malate dehydrogenase activity of MDH1 dimer [cytosol] Biochemical and genetic identity of alpha-keto acid reductase and cytoplasmic malate dehydrogenase from human erythrocytes
9643763 L-malate dehydrogenase activity of MDH2 dimer [mitochondrial matrix] An NADH-tetrazolium-coupled sensitive assay for malate dehydrogenase in mitochondria and crude tissue homogenates
9643582 L-ornithine transmembrane transporter activity of Mitochondrial ornithine transporters [mitochondrial inner membrane] The mitochondrial ornithine transporter. Bacterial expression, reconstitution, functional characterization, and tissue distribution of two human isoforms
9643905 L-phenylalanine:pyruvate aminotransferase activity of PXLP-KYAT1 dimer [cytosol] Purification and characterization of kynurenine aminotransferase I from human brain
9643585 L-proline transmembrane transporter activity of SLC36A4 [plasma membrane] SLC36A4 (hPAT4) is a high affinity amino acid transporter when expressed in Xenopus laevis oocytes
9643289 L-tryptophan transmembrane transporter activity of SLC36A4 [plasma membrane] SLC36A4 (hPAT4) is a high affinity amino acid transporter when expressed in Xenopus laevis oocytes
9643179 L-xylulose reductase (NADP+) activity of DCXR tetramer [plasma membrane] Molecular characterization of mammalian dicarbonyl/L-xylulose reductase and its localization in kidney
9711059 Lys48-specific deubiquitinase activity of RTC [double membrane vesicle viral factory outer membrane] Recognition of Lys48-Linked Di-ubiquitin and Deubiquitinating Activities of the SARS Coronavirus Papain-like Protease
9711003 Lys63-specific deubiquitinase activity of N-glycan pp1a-nsp3 [endoplasmic reticulum membrane] SARS coronavirus papain-like protease inhibits the type I interferon signaling pathway through interaction with the STING-TRAF3-TBK1 complex
9643737 Lys63-specific deubiquitinase activity of OTUD5 [cytosol] DUBA: a deubiquitinase that regulates type I interferon production
9685212 Lys63-specific deubiquitinase activity of RTC [double membrane vesicle viral factory outer membrane] SARS Coronavirus Papain-Like Protease Inhibits the TLR7 Signaling Pathway through Removing Lys63-Linked Polyubiquitination of TRAF3 and TRAF6
9818966 Lys63-specific deubiquitinase activity of TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD [plasma membrane] CYLD Limits Lys63- and Met1-Linked Ubiquitin at Receptor Complexes to Regulate Innate Immune Signaling
9643552 Lys63-specific deubiquitinase activity of TNFAIP3 [cytosol] Zinc-finger protein A20, a regulator of inflammation and cell survival, has de-ubiquitinating activity
9750947 Lys63-specific deubiquitinase activity of USP14 [cytosol] Reversible ubiquitination shapes NLRC5 function and modulates NF-κB activation switch
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