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Entries: CatalystActivityReference
Identifier Name
9643785 tRNA (cytosine-5-)-methyltransferase activity of NSUN2 [nucleoplasm] Identification of human tRNA:m5C methyltransferase catalysing intron-dependent m5C formation in the first position of the anticodon of the pre-tRNA Leu (CAA)
9643822 tRNA (cytosine-5-)-methyltransferase activity of NSUN6 [cytosol] NSUN6 is a human RNA methyltransferase that catalyzes formation of m5C72 in specific tRNAs
9643260 tRNA (cytosine-5-)-methyltransferase activity of TRDMT1 [nucleoplasm] Methylation of tRNAAsp by the DNA methyltransferase homolog Dnmt2
9643493 tRNA (guanine(10)-N2)-methyltransferase activity of TRM11:TRM112 [cytosol] Trm11p and Trm112p are both required for the formation of 2-methylguanosine at position 10 in yeast tRNA
9643154 tRNA (guanine(34)-2'-O)-methyltransferase activity of FTSJ1 [cytosol] Conservation of an intricate circuit for crucial modifications of the tRNAPhe anticodon loop in eukaryotes
9643109 tRNA (guanine(9)-N(1))-methyltransferase activity of TRM10 [nucleoplasm] Identification of the yeast gene encoding the tRNA m1G methyltransferase responsible for modification at position 9
9643118 tRNA (guanine-N1-)-methyltransferase activity of mtRNase P [mitochondrial matrix] A subcomplex of human mitochondrial RNase P is a bifunctional methyltransferase--extensive moonlighting in mitochondrial tRNA biogenesis
9643363 tRNA (guanine-N2-)-methyltransferase activity of TRMT1 [nucleoplasm] The human tRNA(m(2)(2)G(26))dimethyltransferase: functional expression and characterization of a cloned hTRM1 gene
9643110 tRNA (guanine-N7-)-methyltransferase activity of METTL1:WDR4 [nucleoplasm] The tRNA methylase METTL1 is phosphorylated and inactivated by PKB and RSK in vitro and in cells
9643807 tRNA (guanine-N7-)-methyltransferase activity of TRM8:TRM82 [nucleoplasm] Two proteins that form a complex are required for 7-methylguanosine modification of yeast tRNA
9643594 tRNA dihydrouridine synthase activity of SMM1 [cytoplasm] A conserved family of Saccharomyces cerevisiae synthases effects dihydrouridine modification of tRNA
9643134 tRNA dimethylallyltransferase activity of MOD5 [cytosol] Competition between a sterol biosynthetic enzyme and tRNA modification in addition to changes in the protein synthesis machinery causes altered nonsense suppression
9643935 tRNA dimethylallyltransferase activity of TRIT1 [cytosol] The cytoplasmic and nuclear populations of the eukaryote tRNA-isopentenyl transferase have distinct functions with implications in human cancer
9643955 tRNA dimethylallyltransferase activity of TRIT1 [mitochondrial matrix] Defective i6A37 modification of mitochondrial and cytosolic tRNAs results from pathogenic mutations in TRIT1 and its substrate tRNA
9643266 tRNA methyltransferase activity of KIAA1456 [cytoplasm] A human tRNA methyltransferase 9-like protein prevents tumour growth by regulating LIN9 and HIF1-α
9643579 tRNA methyltransferase activity of TRM9 [cytoplasm] Novel methyltransferase for modified uridine residues at the wobble position of tRNA
9643248 tRNA-specific adenosine deaminase activity of ADAT2:ADAT3 [nucleoplasm] Inosine modifications in human tRNAs are incorporated at the precursor tRNA level
9644058 tRNA-specific adenosine deaminase activity of TAD1 [cytoplasm] Tad1p, a yeast tRNA-specific adenosine deaminase, is related to the mammalian pre-mRNA editing enzymes ADAR1 and ADAR2
9643122 tRNA-specific ribonuclease activity of ELAC2 [mitochondrial matrix] Involvement of human ELAC2 gene product in 3' end processing of mitochondrial tRNAs
9643788 tRNA-specific ribonuclease activity of ELAC2 [nucleoplasm] Naturally occurring mutations in human mitochondrial pre-tRNASer(UCN) can affect the transfer ribonuclease Z cleavage site, processing kinetics, and substrate secondary structure
9643542 thiol-dependent ubiquitin-specific protease activity of MonoUb:K164-PCNA:RPA:RFC:USP1:WDR48:Damaged DNA Template [nucleoplasm] Regulation of monoubiquitinated PCNA by DUB autocleavage
9643831 thiol-dependent ubiquitin-specific protease activity of OTULIN,USP5 [cytosol] The de novo synthesis of ubiquitin: identification of deubiquitinases acting on ubiquitin precursors
9643105 thiol-dependent ubiquitin-specific protease activity of UCHL3,USP7,USP9X [cytosol] The de novo synthesis of ubiquitin: identification of deubiquitinases acting on ubiquitin precursors
9643095 thiol-dependent ubiquitinyl hydrolase activity of USP9X:Ub:PEX5L [cytosol] Identification of ubiquitin-specific protease 9X (USP9X) as a deubiquitinase acting on ubiquitin-peroxin 5 (PEX5) thioester conjugate
9643661 thiol-dependent ubiquitinyl hydrolase activity of USP9X:Ub:PEX5S [cytosol] Identification of ubiquitin-specific protease 9X (USP9X) as a deubiquitinase acting on ubiquitin-peroxin 5 (PEX5) thioester conjugate
9643451 thioredoxin peroxidase activity of PRDX1,2,5 [cytosol] Human peroxiredoxin 1 and 2 are not duplicate proteins: the unique presence of CYS83 in Prx1 underscores the structural and functional differences between Prx1 and Prx2
9644071 thioredoxin peroxidase activity of PRDX3,5 [mitochondrial matrix] Reconstitution of the mitochondrial PrxIII antioxidant defence pathway: general properties and factors affecting PrxIII activity and oligomeric state
9643539 thioredoxin peroxidase activity of PRDX5 [cytosol] Human peroxiredoxin 5 is a peroxynitrite reductase
9643701 thioredoxin peroxidase activity of PRDX5-1 [mitochondrial matrix] Human peroxiredoxin 5 is a peroxynitrite reductase
9643312 thioredoxin-disulfide reductase activity of TNXRD1:FAD dimer [cytosol] Truncated mutants of human thioredoxin reductase 1 do not exhibit glutathione reductase activity
9643485 thioredoxin-disulfide reductase activity of TXNRD2 dimer [mitochondrial matrix] Reconstitution of the mitochondrial PrxIII antioxidant defence pathway: general properties and factors affecting PrxIII activity and oligomeric state
9643073 trans-2-enoyl-CoA reductase (NADPH) activity of PECR tetramer [peroxisomal membrane] Molecular cloning and expression of mammalian peroxisomal trans-2-enoyl-coenzyme A reductase cDNAs
9643362 transferase activity of Non-canonical NF-kB initiating TNFRSF memebers [plasma membrane] Self-termination of the terminator
9644072 transferase activity of TSR3 [cytosol] Ribosome biogenesis factor Tsr3 is the aminocarboxypropyl transferase responsible for 18S rRNA hypermodification in yeast and humans
9759577 transferase activity, transferring alkyl or aryl (other than methyl) groups of 3xMMAB [mitochondrial matrix] Redox-Linked Coordination Chemistry Directs Vitamin B12 Trafficking
9643415 transferase activity, transferring alkyl or aryl (other than methyl) groups of TRMT12 [cytoplasm] Structure-function analysis of human TYW2 enzyme required for the biosynthesis of a highly modified Wybutosine (yW) base in phenylalanine-tRNA
9643092 transferase activity, transferring pentosyl groups of TYMP dimer [cytosol] Catabolism of thymidine in human blood platelets: purification and properties of thymidine phosphorylase
9643773 transketolase activity of TKT dimer [cytosol] Aspartate 155 of human transketolase is essential for thiamine diphosphate-magnesium binding, and cofactor binding is required for dimer formation
9643137 transmembrane receptor protein kinase activity of IL7R:TSLP:CRLF2:STAT3 [plasma membrane] Human thymic stromal lymphopoietin preferentially stimulates myeloid cells
9643963 transmembrane receptor protein tyrosine kinase activity of IL12A:IL12B:IL12RB1:p-Y800-IL12RB2:p-Y-TYK2:p-JAK2:2xSTAT4 [plasma membrane] Identification of a STAT4 binding site in the interleukin-12 receptor required for signaling
9643470 transmembrane receptor protein tyrosine kinase activity of IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:STAT3,STAT5,(STAT3:STAT5) [plasma membrane] Tyrosine phosphorylation and activation of STAT5, STAT3, and Janus kinases by interleukins 2 and 15
9643756 transmembrane receptor protein tyrosine kinase activity of IL15RA:IL15:IL2RB:JAK1:IL2RG:JAK3 [plasma membrane] Tyrosine phosphorylation and activation of STAT5, STAT3, and Janus kinases by interleukins 2 and 15
9643584 transmembrane receptor protein tyrosine kinase activity of IL23A:IL12B:IL12RB1:p-TYK2:p-Y-IL23R:p-JAK2:STAT3:STAT4 [plasma membrane] Defining the functional binding sites of interleukin 12 receptor β1 and interleukin 23 receptor to Janus kinases
9643690 transmembrane receptor protein tyrosine kinase activity of IL35:IL6ST:p-JAK1:IL12RB2:p-JAK2:STAT1:STAT4 [plasma membrane] The composition and signaling of the IL-35 receptor are unconventional
9643394 transmembrane transporter activity of SEC61 subunit Alpha-1 [phagocytic vesicle membrane] ER-phagosome fusion defines an MHC class I cross-presentation compartment in dendritic cells
9643650 transmembrane transporter activity of Translocon [phagocytic vesicle membrane] The Sec61 complex is located in both the ER and the ER-Golgi intermediate compartment
9643918 transmembrane transporter activity of peroxisomal glyoxylate carrier [peroxisomal membrane] Metabolic Interplay between Peroxisomes and Other Subcellular Organelles Including Mitochondria and the Endoplasmic Reticulum
9643074 transmembrane transporter activity of plasma membrane glyoxylate carrier [plasma membrane] Metabolic Interplay between Peroxisomes and Other Subcellular Organelles Including Mitochondria and the Endoplasmic Reticulum
9643916 triglyceride lipase activity of PNPLA4 [cytosol] A comparative study of human GS2, its paralogues, and its rat orthologue
9643959 triglyceride lipase activity of PNPLA5 [cytosol] A comparative study of human GS2, its paralogues, and its rat orthologue
9643811 trimethyllysine dioxygenase activity of TMLHE:AscH-:Fe2+ dimer [mitochondrial matrix] Functional analysis of TMLH variants and definition of domains required for catalytic activity and mitochondrial targeting
9643829 triokinase activity of TKFC:2Mg2+ dimer [cytosol] Bifunctional homodimeric triokinase/FMN cyclase: contribution of protein domains to the activities of the human enzyme and molecular dynamics simulation of domain movements
9644044 triose-phosphate isomerase activity of TPI1 dimer [cytosol] Primary structure of human triosephosphate isomerase
9644078 triphosphoric monoester hydrolase activity of SAMHD1:Zn2+ tetramer [nucleoplasm] HIV-1 restriction factor SAMHD1 is a deoxynucleoside triphosphate triphosphohydrolase
9643939 tryptophan 2,3-dioxygenase activity of IDO1 [cytosol] Crystal structure of human indoleamine 2,3-dioxygenase: catalytic mechanism of O2 incorporation by a heme-containing dioxygenase
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