Reactome | SOS1-mediated nucleotide exchange of RAS (HB-EFG-initiated)

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SOS1-mediated nucleotide exchange of RAS (HB-EFG-initiated) Show undefined attributes

catalystActivity	[CatalystActivity:10522747] guanyl-nucleotide exchange factor activity of GRB2:SOS1:HB-EGF:p-6Y-EGFR [plasma membrane]
category	transition
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:10486564] Wright, Adam, 2024-03-07
dbId	10522749
displayName	SOS1-mediated nucleotide exchange of RAS (HB-EFG-initiated)
eventOf	[Pathway:R-XTR-2179392] EGFR Transactivation by Gastrin - Xenopus tropicalis
evidenceType	[EvidenceType:9864366] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-2179407] SOS1-mediated nucleotide exchange of RAS (HB-EFG-initiated) - Homo sapiens
input	[SimpleEntity:R-ALL-29438] GTP [cytosol] [Complex:R-XTR-109796] p21 RAS:GDP [plasma membrane]
isInDisease	false
isInferred	true
name	SOS1-mediated nucleotide exchange of RAS (HB-EFG-initiated)
output	[SimpleEntity:R-ALL-29420] GDP [cytosol] [Complex:R-XTR-109783] p21 RAS:GTP [plasma membrane]
precedingEvent	[Reaction:R-XTR-2179415] GRB2:SOS1 binds to HBEGF:p-Y-EGFR - Xenopus tropicalis
releaseDate	2024-03-27
schemaClass	Reaction
species	[Species:205621] Xenopus tropicalis
stId	R-XTR-2179407
summation	[Summation:9864365] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-XTR-2179392] EGFR Transactivation by Gastrin
(inferredTo)	[Reaction:R-HSA-2179407] SOS1-mediated nucleotide exchange of RAS (HB-EFG-initiated)

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