Reactome | IL22:IL22RA1:JAK1:IL10RB:TYK2 phosphorylates JAK1,TYK2

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IL22:IL22RA1:JAK1:IL10RB:TYK2 phosphorylates JAK1,TYK2 Show undefined attributes

catalystActivity	[CatalystActivity:10414519] transmembrane receptor protein tyrosine kinase activity of IL22:IL22RA1:JAK1:IL10RB:TYK2 [plasma membrane]
category	omitted
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol [Compartment:984] extracellular region
created	[InstanceEdit:10314670] Wright, Adam, 2024-03-07
dbId	10414521
displayName	IL22:IL22RA1:JAK1:IL10RB:TYK2 phosphorylates JAK1,TYK2
eventOf	[Pathway:R-SSC-8854691] Interleukin-20 family signaling - Sus scrofa
evidenceType	[EvidenceType:9864366] inferred by electronic annotation
followingEvent	[BlackBoxEvent:R-SSC-8986995] IL22:IL22RA1:p-JAK1:IL10RB:p-TYK2 phosphorylates IL22RA - Sus scrofa
inferredFrom	[BlackBoxEvent:R-HSA-8987042] IL22:IL22RA1:JAK1:IL10RB:TYK2 phosphorylates JAK1,TYK2 - Homo sapiens
input	2 × [SimpleEntity:R-ALL-113592] ATP [cytosol] [Complex:R-SSC-8854697] IL22:IL22RA1:JAK1:IL10RB:TYK2 [plasma membrane]
isInDisease	false
isInferred	true
name	IL22:IL22RA1:JAK1:IL10RB:TYK2 phosphorylates JAK1,TYK2 TYK1 and JAK1 are phosphorylated by IL22:IL22RA1:JAK1:IL10RB:TYK2 receptor complex
output	2 × [SimpleEntity:R-ALL-29370] ADP [cytosol] [Complex:R-SSC-8987249] IL22:IL22RA1:p-JAK1:IL10RB:p-TYK2 [plasma membrane]
precedingEvent	[Reaction:R-SSC-8854645] IL22:IL22RA1:JAK1 binds IL10RB:TYK2 - Sus scrofa
releaseDate	2024-03-27
schemaClass	BlackBoxEvent
species	[Species:49633] Sus scrofa
stId	R-SSC-8987042
summation	[Summation:9864365] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-SSC-8854691] Interleukin-20 family signaling
(precedingEvent)	[BlackBoxEvent:R-SSC-8986995] IL22:IL22RA1:p-JAK1:IL10RB:p-TYK2 phosphorylates IL22RA
(inferredTo)	[BlackBoxEvent:R-HSA-8987042] IL22:IL22RA1:JAK1:IL10RB:TYK2 phosphorylates JAK1,TYK2

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