Reactome | PC carboxylates PYR to OA

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PC carboxylates PYR to OA Show undefined attributes

catalystActivity	[CatalystActivity:10316325] pyruvate carboxylase activity of PC tetramer [mitochondrial matrix]
category	transition
compartment	[Compartment:5460] mitochondrial matrix
created	[InstanceEdit:10314670] Wright, Adam, 2024-03-07
dbId	10316327
displayName	PC carboxylates PYR to OA
eventOf	[Pathway:R-SSC-70263] Gluconeogenesis - Sus scrofa [Pathway:R-SSC-70268] Pyruvate metabolism - Sus scrofa
evidenceType	[EvidenceType:9864366] inferred by electronic annotation
followingEvent	[Reaction:R-SSC-372819] PCK2 phosphorylates OA to yield PEP - Sus scrofa [Reaction:R-SSC-70613] GOT2 transaminates OA and L-Glu - Sus scrofa [Reaction:R-SSC-70975] CS acetylates OA to citrate - Sus scrofa
inferredFrom	[Reaction:R-HSA-70501] PC carboxylates PYR to OA - Homo sapiens
input	[SimpleEntity:R-ALL-113593] ATP [mitochondrial matrix] [SimpleEntity:R-ALL-29896] HCO3- [mitochondrial matrix] [SimpleEntity:R-ALL-113557] PYR [mitochondrial matrix]
isInDisease	false
isInferred	true
name	PC carboxylates PYR to OA PC catalyzes the carboxylation of PYR to form OA ATP + hydrogencarbonate + pyruvate => ADP + H(+) + oxaloacetate + phosphate
output	[SimpleEntity:R-ALL-113581] ADP [mitochondrial matrix] [SimpleEntity:R-ALL-113529] H+ [mitochondrial matrix] [SimpleEntity:R-ALL-113587] OA [mitochondrial matrix] [SimpleEntity:R-ALL-113548] Pi [mitochondrial matrix]
precedingEvent	[Reaction:R-SSC-9012016] FAHD1 dimer hydrolyses OA to PYR - Sus scrofa [Reaction:R-SSC-9012268] ME2 tetramer decarboxylates MAL to PYR - Sus scrofa [Reaction:R-SSC-9012349] ME3 tetramer decarboxylates MAL to PYR - Sus scrofa
regulatedBy	[Requirement:R-GGA-354223] Requirement by 'Ac-CoA [mitochondrial matrix]' [NegativeRegulation:9865795] Negative regulation by '2OG [mitochondrial matrix]' [NegativeRegulation:9865796] Negative regulation by 'L-Glu [mitochondrial matrix]' [NegativeRegulation:9865797] Negative regulation by 'MAL [mitochondrial matrix]'
releaseDate	2024-03-27
schemaClass	Reaction
species	[Species:49633] Sus scrofa
stId	R-SSC-70501
summation	[Summation:9864365] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-SSC-70268] Pyruvate metabolism [Pathway:R-SSC-70263] Gluconeogenesis
(precedingEvent)	[Reaction:R-SSC-372819] PCK2 phosphorylates OA to yield PEP [Reaction:R-SSC-70975] CS acetylates OA to citrate [Reaction:R-SSC-70613] GOT2 transaminates OA and L-Glu
(inferredTo)	[Reaction:R-HSA-70501] PC carboxylates PYR to OA