Reactome | POLD,POLE [nucleoplasm]

Schema > CandidateSet > Entries

compartment	[Compartment:7660] nucleoplasm
componentOf	[Complex:R-SSC-6790531] PCNA:POLD,POLE [nucleoplasm] - Sus scrofa [Complex:R-SSC-5653837] PCNA:POLD,POLE:RPA:RFC:TLS-DNA Template [nucleoplasm] - Sus scrofa
consumedByEvent	[Reaction:R-SSC-5653838] POLD,POLE binds deISGylated PCNA after TLS - Sus scrofa
created	[InstanceEdit:10314670] Wright, Adam, 2024-03-07
dbId	10322445
displayName	POLD,POLE [nucleoplasm]
hasCandidate	[Complex:R-SSC-68483] DNA polymerase epsilon [nucleoplasm] - Sus scrofa
hasMember	[Complex:R-SSC-68450] DNA Polymerase delta tetramer [nucleoplasm] - Sus scrofa
inDisease	false
inferredFrom	[CandidateSet:R-HSA-5651800] POLD,POLE [nucleoplasm] - Homo sapiens
memberOf	[DefinedSet:R-SSC-6790535] POLD,POLE,POLK [nucleoplasm] - Sus scrofa
name	POLD,POLE
producedByEvent	[Reaction:R-SSC-5652009] RAD18:UBE2B or RBX1:CUL4:DDB1:DTL monoubiquitinates PCNA - Sus scrofa
schemaClass	CandidateSet
species	[Species:49633] Sus scrofa
stId	R-SSC-5651800

(input)	[Reaction:R-SSC-5653838] POLD,POLE binds deISGylated PCNA after TLS
(hasComponent)	[Complex:R-SSC-5653837] PCNA:POLD,POLE:RPA:RFC:TLS-DNA Template [nucleoplasm] [Complex:R-SSC-6790531] PCNA:POLD,POLE [nucleoplasm] [Complex:R-SSC-5651799] PCNA:POLD,POLE:RPA:RFC [nucleoplasm]
(output)	[Reaction:R-SSC-5652009] RAD18:UBE2B or RBX1:CUL4:DDB1:DTL monoubiquitinates PCNA
(activeUnit)	[CatalystActivity:10322460] DNA-directed DNA polymerase activity of APEX1:FEN1:PCNA:POLD,POLE:RPA:RFC:SSB(3'dNMP-displaced 5'ddRP)-dsDNA [nucleoplasm] [CatalystActivity:10393175] DNA-directed DNA polymerase activity of (PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC:Incised DNA without lesion [nucleoplasm] [CatalystActivity:10395736] DNA-directed DNA polymerase activity of TC-NER post-incision complex:incised DNA without lesion:trimmed nascent mRNA:PCNA:(PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm]
(hasMember)	[DefinedSet:R-SSC-6790535] POLD,POLE,POLK [nucleoplasm]
(inferredTo)	[CandidateSet:R-HSA-5651800] POLD,POLE [nucleoplasm]