Reactome | USP7 [nucleoplasm]

Schema > EntityWithAccessionedSequence > Entries

catalystActivities	[CatalystActivity:10376874] cysteine-type deubiquitinase activity of USP7 [nucleoplasm]
compartment	[Compartment:7660] nucleoplasm
componentOf	[Complex:R-SSC-6782666] USP7:PolyUb-TP53,PolyUb-MDM2,PolyUb-MDM4,PolyUb-FOXO4,PolyUb-PTEN [nucleoplasm] - Sus scrofa [Complex:R-SSC-6782656] USP7:TP53,MDM2,MDM4,FOXO4,PTEN [nucleoplasm] - Sus scrofa
consumedByEvent	[Reaction:R-SSC-3222072] DAXX binds Ub-MDM2 and USP7 - Sus scrofa
created	[InstanceEdit:10314670] Wright, Adam, 2024-03-07
dbId	10376852
displayName	USP7 [nucleoplasm]
endCoordinate	1102
inDisease	false
inferredFrom	[EntityWithAccessionedSequence:R-HSA-3215278] USP7 [nucleoplasm] - Homo sapiens
name	USP7 USP7 F1RKZ6
producedByEvent	[Reaction:R-SSC-3215295] USP7 deubiquitinates MDM2 - Sus scrofa
referenceEntity	[ReferenceGeneProduct:10376850] UniProt:F1RKZ6
referenceType	ReferenceGeneProduct
schemaClass	EntityWithAccessionedSequence
species	[Species:49633] Sus scrofa
stId	R-SSC-3215278
startCoordinate	1

(activeUnit)	[CatalystActivity:10392224] cysteine-type deubiquitinase activity of USP7:PolyUb-TP53,PolyUb-MDM2,PolyUb-MDM4,PolyUb-FOXO4,PolyUb-PTEN [nucleoplasm] [CatalystActivity:10376864] cysteine-type deubiquitinase activity of DAXX:(PolyUb,p-S166,S188-MDM2):USP7 [nucleoplasm]
(hasComponent)	[Complex:R-SSC-6782656] USP7:TP53,MDM2,MDM4,FOXO4,PTEN [nucleoplasm] [Complex:R-SSC-6782666] USP7:PolyUb-TP53,PolyUb-MDM2,PolyUb-MDM4,PolyUb-FOXO4,PolyUb-PTEN [nucleoplasm] [Complex:R-SSC-6781845] UVSSA:USP7 [nucleoplasm] [Complex:R-SSC-3222079] DAXX:(PolyUb,p-S166,S188-MDM2):USP7 [nucleoplasm]
(output)	[Reaction:R-SSC-3215295] USP7 deubiquitinates MDM2
(input)	[Reaction:R-SSC-3222072] DAXX binds Ub-MDM2 and USP7
(physicalEntity)	[CatalystActivity:10376874] cysteine-type deubiquitinase activity of USP7 [nucleoplasm]
(inferredTo)	[EntityWithAccessionedSequence:R-HSA-3215278] USP7 [nucleoplasm]