Reactome | PIP3 binds to RhoA and activates it

Schema > Reaction > Entries

PIP3 binds to RhoA and activates it Show undefined attributes

category	binding
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:10314670] Wright, Adam, 2024-03-07
dbId	10335312
displayName	PIP3 binds to RhoA and activates it
eventOf	[Pathway:R-SSC-392451] G beta:gamma signalling through PI3Kgamma - Sus scrofa [Pathway:R-SSC-198203] PI3K/AKT activation - Sus scrofa
evidenceType	[EvidenceType:9864366] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-202692] PIP3 binds to RhoA and activates it - Homo sapiens
input	[SimpleEntity:R-ALL-179838] PI(3,4,5)P3 [plasma membrane] [EntityWithAccessionedSequence:R-SSC-194510] RHOA [plasma membrane]
isInDisease	false
isInferred	true
name	PIP3 binds to RhoA and activates it
output	[Complex:R-SSC-202676] PIP3:RhoA [plasma membrane]
precedingEvent	[Reaction:R-SSC-392300] G beta:gamma activated PI3Kgamma converts PIP2 to PIP3 - Sus scrofa [Reaction:R-SSC-198266] PI3K produces PIP3 and other phosphatidyl inositides - Sus scrofa
releaseDate	2024-03-27
schemaClass	Reaction
species	[Species:49633] Sus scrofa
stId	R-SSC-202692
summation	[Summation:9864365] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-SSC-392451] G beta:gamma signalling through PI3Kgamma [Pathway:R-SSC-198203] PI3K/AKT activation
(inferredTo)	[Reaction:R-HSA-202692] PIP3 binds to RhoA and activates it

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