Reactome | ALK autophosphorylation

Schema > Reaction > Entries

ALK autophosphorylation Show undefined attributes

catalystActivity	[CatalystActivity:10334464] protein tyrosine kinase activity of ligand-bound ALK dimer [plasma membrane]
category	transition
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:10314670] Wright, Adam, 2024-03-07
dbId	10334468
displayName	ALK autophosphorylation
eventOf	[Pathway:R-SSC-201556] Signaling by ALK - Sus scrofa
evidenceType	[EvidenceType:9864366] inferred by electronic annotation
followingEvent	[BlackBoxEvent:R-SSC-201515] Active ALK recruits PI3K - Sus scrofa [Reaction:R-SSC-9700149] Active ALK binds PLCG1 - Sus scrofa [Reaction:R-SSC-9700156] Active ALK dimer binds IRS1 - Sus scrofa [Reaction:R-SSC-9700154] Active ALK binds SHC1 - Sus scrofa [Reaction:R-SSC-9700200] PTPRZ dephosphorylates ligand-bound ALK dimers - Sus scrofa [Reaction:R-SSC-9701485] Active ALK binds JAK3 - Sus scrofa [BlackBoxEvent:R-SSC-9701524] STAT3 is phosphorylated downstream of active ALK - Sus scrofa
inferredFrom	[Reaction:R-HSA-201521] ALK autophosphorylation - Homo sapiens
input	6 × [SimpleEntity:R-ALL-113592] ATP [cytosol] [CandidateSet:R-SSC-9850908] ligand-bound ALK dimer [plasma membrane]
isInDisease	false
isInferred	true
name	ALK autophosphorylation
output	[CandidateSet:R-SSC-9850879] Active ALK dimer [plasma membrane] 6 × [SimpleEntity:R-ALL-29370] ADP [cytosol]
precedingEvent	[Reaction:R-SSC-9842656] ALK binds ALKAL ligand - Sus scrofa
regulatedBy	[NegativeRegulation:10334469] Negative regulation by 'ALK dimer:ligand:type I ALK binding TKI [plasma membrane]'
releaseDate	2024-03-27
schemaClass	Reaction
species	[Species:49633] Sus scrofa
stId	R-SSC-201521
summation	[Summation:9864365] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-SSC-201556] Signaling by ALK
(precedingEvent)	[BlackBoxEvent:R-SSC-201515] Active ALK recruits PI3K [Reaction:R-SSC-9700149] Active ALK binds PLCG1 [Reaction:R-SSC-9700156] Active ALK dimer binds IRS1 [Reaction:R-SSC-9700154] Active ALK binds SHC1 [Reaction:R-SSC-9700200] PTPRZ dephosphorylates ligand-bound ALK dimers [Reaction:R-SSC-9701485] Active ALK binds JAK3 [BlackBoxEvent:R-SSC-9701524] STAT3 is phosphorylated downstream of active ALK
(inferredTo)	[Reaction:R-HSA-201521] ALK autophosphorylation

Cite Us!