Reactome | MLH1:PMS2:MSH2:MSH6:ATP:PCNA:DNA containing 1-2 base mismatch and single strand incision [nucleoplasm]

Schema > Complex > Entries

compartment	[Compartment:7660] nucleoplasm
consumedByEvent	[Reaction:R-SPO-5358597] EXO1 interacts with MSH2:MSH6 (MutSalpha) and MLH1:PMS2 (MutLalpha) - Schizosaccharomyces pombe
created	[InstanceEdit:10871105] Wright, Adam, 2024-03-08
dbId	10887259
displayName	MLH1:PMS2:MSH2:MSH6:ATP:PCNA:DNA containing 1-2 base mismatch and single strand incision [nucleoplasm]
hasComponent	[OtherEntity:R-ALL-5358526] DNA containing 1-2 base mismatch and single-strand incision [nucleoplasm] [Complex:R-SPO-5357522] MLH1:PMS2 [nucleoplasm] [Complex:R-SPO-5358531] MSH2:MSH6:ATP [nucleoplasm] [Complex:R-SPO-68440] PCNA homotrimer [nucleoplasm]
inDisease	false
inferredFrom	[Complex:R-HSA-5358528] MLH1:PMS2:MSH2:MSH6:ATP:PCNA:DNA containing 1-2 base mismatch and single strand incision [nucleoplasm] - Homo sapiens
name	MLH1:PMS2:MSH2:MSH6:ATP:PCNA:DNA containing 1-2 base mismatch and single strand incision
producedByEvent	[Reaction:R-SPO-5358518] MLH1:PMS2 makes single strand incision near 1-2 base mismatch - Schizosaccharomyces pombe
schemaClass	Complex
species	[Species:68324] Schizosaccharomyces pombe
stId	R-SPO-5358528
summation	[Summation:9864367] This complex/polymer has been computationally inferred (based on PANTHER) from a complex/polymer involved in an event that has been demonstrated in another species.

(input)	[Reaction:R-SPO-5358597] EXO1 interacts with MSH2:MSH6 (MutSalpha) and MLH1:PMS2 (MutLalpha)
(output)	[Reaction:R-SPO-5358518] MLH1:PMS2 makes single strand incision near 1-2 base mismatch
(inferredTo)	[Complex:R-HSA-5358528] MLH1:PMS2:MSH2:MSH6:ATP:PCNA:DNA containing 1-2 base mismatch and single strand incision [nucleoplasm]

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