Reactome | HMGCS1 condenses Ac-CoA and ACA-CoA to form bHMG-CoA

Schema > Reaction > Entries

HMGCS1 condenses Ac-CoA and ACA-CoA to form bHMG-CoA Show undefined attributes

catalystActivity	[CatalystActivity:10877303] hydroxymethylglutaryl-CoA synthase activity of HMGCS1 [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10871105] Wright, Adam, 2024-03-08
dbId	10877305
displayName	HMGCS1 condenses Ac-CoA and ACA-CoA to form bHMG-CoA
eventOf	[Pathway:R-SPO-191273] Cholesterol biosynthesis - Schizosaccharomyces pombe
evidenceType	[EvidenceType:9864366] inferred by electronic annotation
followingEvent	[Reaction:R-SPO-191352] HMGCR dimer reduces bHMG-CoA to MVA - Schizosaccharomyces pombe
inferredFrom	[Reaction:R-HSA-191323] HMGCS1 condenses Ac-CoA and ACA-CoA to form bHMG-CoA - Homo sapiens
input	[SimpleEntity:R-ALL-76183] Ac-CoA [cytosol] [SimpleEntity:R-ALL-191293] ACA-CoA [cytosol] [SimpleEntity:R-ALL-29356] H2O [cytosol]
isInDisease	false
isInferred	true
name	HMGCS1 condenses Ac-CoA and ACA-CoA to form bHMG-CoA Condensation of acetyl CoA with acetoacetyl CoA to form HMG-CoA
output	[SimpleEntity:R-ALL-191374] bHMG-CoA [cytosol] [SimpleEntity:R-ALL-76194] CoA-SH [cytosol] [SimpleEntity:R-ALL-70106] H+ [cytosol]
precedingEvent	[Reaction:R-SPO-8848215] ACAT2 condenses 2 Ac-CoA to form ACA-CoA - Schizosaccharomyces pombe
releaseDate	2024-03-27
schemaClass	Reaction
species	[Species:68324] Schizosaccharomyces pombe
stId	R-SPO-191323
summation	[Summation:9864365] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-SPO-191273] Cholesterol biosynthesis
(precedingEvent)	[Reaction:R-SPO-191352] HMGCR dimer reduces bHMG-CoA to MVA
(inferredTo)	[Reaction:R-HSA-191323] HMGCS1 condenses Ac-CoA and ACA-CoA to form bHMG-CoA

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