Reactome | Dephosphorylation of JAK1 by SHP1

Schema > Reaction > Entries

Dephosphorylation of JAK1 by SHP1 Show undefined attributes

catalystActivity	[CatalystActivity:10027621] protein tyrosine phosphatase activity of PTPN6 [cytosol]
category	transition
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:9979708] Wright, Adam, 2024-03-07
dbId	10027623
displayName	Dephosphorylation of JAK1 by SHP1
eventOf	[Pathway:R-RNO-912694] Regulation of IFNA/IFNB signaling - Rattus norvegicus
evidenceType	[EvidenceType:9864366] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-997314] Dephosphorylation of JAK1 by SHP1 - Homo sapiens
input	[SimpleEntity:R-ALL-29356] H2O [cytosol] [Complex:R-RNO-997300] IFNA/B:IFNAR2:p-JAK1:STAT2:IFNAR1:TYK2 [plasma membrane]
isInDisease	false
isInferred	true
name	Dephosphorylation of JAK1 by SHP1
output	[Complex:R-RNO-909703] IFNA/B:IFNAR2:JAK1:STAT2:IFNAR1:TYK2 [plasma membrane] [SimpleEntity:R-ALL-29372] Pi [cytosol]
precedingEvent	[Reaction:R-RNO-997311] Dephosphorylation of TYK2 by PTP1B - Rattus norvegicus
releaseDate	2024-03-27
schemaClass	Reaction
species	[Species:48895] Rattus norvegicus
stId	R-RNO-997314
summation	[Summation:9864365] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-RNO-912694] Regulation of IFNA/IFNB signaling
(inferredTo)	[Reaction:R-HSA-997314] Dephosphorylation of JAK1 by SHP1