Reactome | Caspase-8 and FLIP(L) processing at TNFR signaling complex

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Caspase-8 and FLIP(L) processing at TNFR signaling complex Show undefined attributes

category	omitted
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:9979708] Wright, Adam, 2024-03-07
dbId	10090860
displayName	Caspase-8 and FLIP(L) processing at TNFR signaling complex
eventOf	[Pathway:R-RNO-5357905] Regulation of TNFR1 signaling - Rattus norvegicus
evidenceType	[EvidenceType:9864366] inferred by electronic annotation
followingEvent	[BlackBoxEvent:R-RNO-9697750] RIPK1 is cleaved by CASP8:FLIP(L) - Rattus norvegicus
inferredFrom	[BlackBoxEvent:R-HSA-9697747] Caspase-8 and FLIP(L) processing at TNFR signaling complex - Homo sapiens
input	[Complex:R-RNO-3465532] TRADD:TRAF2:RIP1:FADD:procaspase-8:FLIP(L) [cytosol]
isInDisease	false
isInferred	true
name	Caspase-8 and FLIP(L) processing at TNFR signaling complex
output	[EntityWithAccessionedSequence:R-RNO-3465483] Cflar [cytosol] [Complex:R-RNO-9697746] TRADD:TRAF2:RIPK1:FADD:p43/p41CASP8:p43 FLIP(L) [plasma membrane]
precedingEvent	[Reaction:R-RNO-3371360] FLIP(L) and procaspase-8 form heterodimer in TNF signaling - Rattus norvegicus
releaseDate	2024-03-27
schemaClass	BlackBoxEvent
species	[Species:48895] Rattus norvegicus
stId	R-RNO-9697747
summation	[Summation:9864365] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-RNO-5357905] Regulation of TNFR1 signaling
(precedingEvent)	[BlackBoxEvent:R-RNO-9697750] RIPK1 is cleaved by CASP8:FLIP(L)
(inferredTo)	[BlackBoxEvent:R-HSA-9697747] Caspase-8 and FLIP(L) processing at TNFR signaling complex

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