Reactome | ERBB2 binds TKIs

Schema > Reaction > Entries

category	binding
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:9979708] Wright, Adam, 2024-03-07
dbId	10089796
displayName	ERBB2 binds TKIs
eventOf	[Pathway:R-RNO-9652282] Drug-mediated inhibition of ERBB2 signaling - Rattus norvegicus
evidenceType	[EvidenceType:9864366] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-9652264] ERBB2 binds TKIs - Homo sapiens
input	[Complex:R-RNO-1227970] ERBB2:ERBIN:HSP90:CDC37 [plasma membrane] [DefinedSet:R-ALL-9652360] lapatinib, neratinib, afatinib, AZ5104, tesevatinib, canertinib, sapitinib, CP-724714, AEE78 [cytosol]
isInDisease	false
isInferred	true
name	ERBB2 binds TKIs
output	[Complex:R-RNO-9665220] ERBB2:TKIs:ERBIN:HSP90:CDC37 [plasma membrane]
releaseDate	2024-03-27
schemaClass	Reaction
species	[Species:48895] Rattus norvegicus
stId	R-RNO-9652264
summation	[Summation:9864365] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

(hasEvent)	[Pathway:R-RNO-9652282] Drug-mediated inhibition of ERBB2 signaling
(inferredTo)	[Reaction:R-HSA-9652264] ERBB2 binds TKIs