Reactome | BRAF autophosphorylates downstream of RAP1 and NGF

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BRAF autophosphorylates downstream of RAP1 and NGF Show undefined attributes

catalystActivity	[CatalystActivity:10088318] protein serine/threonine kinase activity of RAP1:GTP:B-Raf complex [endosome membrane]
category	transition
compartment	[Compartment:74700] endosome membrane
created	[InstanceEdit:9979708] Wright, Adam, 2024-03-07
dbId	10088320
displayName	BRAF autophosphorylates downstream of RAP1 and NGF
eventOf	[Pathway:R-RNO-170968] Frs2-mediated activation - Rattus norvegicus
evidenceType	[EvidenceType:9864366] inferred by electronic annotation
followingEvent	[Reaction:R-RNO-9610152] Activated BRAF recruits MAP2Ks and MAPKs to the endosome - Rattus norvegicus [Reaction:R-RNO-9610153] Activated BRAF phosphorylates MAP2K dimers downstream of RAP1 and NGF - Rattus norvegicus
inferredFrom	[Reaction:R-HSA-9610163] BRAF autophosphorylates downstream of RAP1 and NGF - Homo sapiens
input	2 × [SimpleEntity:R-ALL-113592] ATP [cytosol] [Complex:R-RNO-190082] RAP1:GTP:B-Raf complex [endosome membrane]
isInDisease	false
isInferred	true
name	BRAF autophosphorylates downstream of RAP1 and NGF
output	2 × [SimpleEntity:R-ALL-29370] ADP [cytosol] [Complex:R-RNO-9610130] RAP1:GTP:activated BRAF dimer [endosome membrane]
releaseDate	2024-03-27
schemaClass	Reaction
species	[Species:48895] Rattus norvegicus
stId	R-RNO-9610163
summation	[Summation:9864365] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-RNO-170968] Frs2-mediated activation
(precedingEvent)	[Reaction:R-RNO-9610152] Activated BRAF recruits MAP2Ks and MAPKs to the endosome [Reaction:R-RNO-9610153] Activated BRAF phosphorylates MAP2K dimers downstream of RAP1 and NGF
(inferredTo)	[Reaction:R-HSA-9610163] BRAF autophosphorylates downstream of RAP1 and NGF