Reactome | RAC1 and CDC42 activate PAK2

Schema > Reaction > Entries

RAC1 and CDC42 activate PAK2 Show undefined attributes

category	transition
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:9979708] Wright, Adam, 2024-03-07
dbId	10085112
displayName	RAC1 and CDC42 activate PAK2
eventOf	[Pathway:R-RNO-5627123] RHO GTPases activate PAKs - Rattus norvegicus
evidenceType	[EvidenceType:9864366] inferred by electronic annotation
followingEvent	[Reaction:R-RNO-5627775] Autophosphorylation of PAK1,2,3 - Rattus norvegicus
inferredFrom	[Reaction:R-HSA-8981931] RAC1 and CDC42 activate PAK2 - Homo sapiens
input	[DefinedSet:R-RNO-389778] CDC42:GTP, RAC1:GTP [plasma membrane] [Complex:R-RNO-2685645] PAK2 dimer [cytosol]
isInDisease	false
isInferred	true
name	RAC1 and CDC42 activate PAK2
output	[Complex:R-RNO-8981927] CDC42:GTP,RAC1:GTP:PAK2 [plasma membrane] [EntityWithAccessionedSequence:R-RNO-211604] PAK2 [cytosol]
precedingEvent	[Reaction:R-RNO-389348] Activation of Rac1 by pVav1 - Rattus norvegicus [Reaction:R-RNO-389350] Activation of Cdc42 by pVav1 - Rattus norvegicus [Reaction:R-RNO-418850] Activation of Cdc42 - Rattus norvegicus [Reaction:R-RNO-418856] Activation of Rac1 - Rattus norvegicus [Reaction:R-RNO-8848618] Activation of RAC1 by the PXN:CRK complex - Rattus norvegicus
releaseDate	2024-03-27
schemaClass	Reaction
species	[Species:48895] Rattus norvegicus
stId	R-RNO-8981931
summation	[Summation:9864365] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-RNO-5627123] RHO GTPases activate PAKs
(precedingEvent)	[Reaction:R-RNO-5627775] Autophosphorylation of PAK1,2,3
(inferredTo)	[Reaction:R-HSA-8981931] RAC1 and CDC42 activate PAK2