Reactome | BCKDH synthesizes BCAA-CoA from KIC, KMVA, KIV

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BCKDH synthesizes BCAA-CoA from KIC, KMVA, KIV Show undefined attributes

catalystActivity	[CatalystActivity:9981810] CoA-transferase activity of BCKDH [mitochondrial matrix]
category	transition
compartment	[Compartment:5460] mitochondrial matrix
created	[InstanceEdit:9979708] Wright, Adam, 2024-03-07
dbId	9981812
displayName	BCKDH synthesizes BCAA-CoA from KIC, KMVA, KIV
eventOf	[Pathway:R-RNO-70895] Branched-chain amino acid catabolism - Rattus norvegicus
evidenceType	[EvidenceType:9864366] inferred by electronic annotation
followingEvent	[Reaction:R-RNO-70745] isovaleryl-CoA + FAD => beta-methylcrotonyl-CoA + FADH2 - Rattus norvegicus [Reaction:R-RNO-70800] alpha-methylbutyryl-CoA + FAD => tiglyl-CoA + FADH2 - Rattus norvegicus [Reaction:R-RNO-70859] isobutyryl-CoA + FAD => methacrylyl-CoA + FADH2 - Rattus norvegicus
inferredFrom	[Reaction:R-HSA-70713] BCKDH synthesizes BCAA-CoA from KIC, KMVA, KIV - Homo sapiens
input	[SimpleEntity:R-ALL-29374] CoA-SH [mitochondrial matrix] [DefinedSet:R-ALL-508181] KIC, KMVA, KIV [mitochondrial matrix] [SimpleEntity:R-ALL-113526] NAD+ [mitochondrial matrix]
isInDisease	false
isInferred	true
name	BCKDH synthesizes BCAA-CoA from KIC, KMVA, KIV a-ketoisocaproate, a-keto b-methylvalerate, or a-ketoisovalerate + CoA + NAD+ => isovaleryl-CoA, a-methylbutyryl-CoA, or isobuyryl-CoA + CO2 + NADH + H+ Oxidative decarboxylation of branched-chain alpha-keto acids
output	[DefinedSet:R-ALL-508261] BCAA-CoAs [mitochondrial matrix] [SimpleEntity:R-ALL-29376] CO2 [mitochondrial matrix] [SimpleEntity:R-ALL-29362] NADH [mitochondrial matrix]
precedingEvent	[Reaction:R-RNO-70724] leu, ile, or val + alpha-ketoglutarate <=> a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate [BCAT2] - Rattus norvegicus
releaseDate	2024-03-27
schemaClass	Reaction
species	[Species:48895] Rattus norvegicus
stId	R-RNO-70713
summation	[Summation:9864365] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-RNO-70895] Branched-chain amino acid catabolism
(precedingEvent)	[Reaction:R-RNO-70745] isovaleryl-CoA + FAD => beta-methylcrotonyl-CoA + FADH2 [Reaction:R-RNO-70800] alpha-methylbutyryl-CoA + FAD => tiglyl-CoA + FADH2 [Reaction:R-RNO-70859] isobutyryl-CoA + FAD => methacrylyl-CoA + FADH2
(inferredTo)	[Reaction:R-HSA-70713] BCKDH synthesizes BCAA-CoA from KIC, KMVA, KIV

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